WO2022125776A3 - Methods and compositions for treating kidney diseases - Google Patents

Methods and compositions for treating kidney diseases Download PDF

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Publication number
WO2022125776A3
WO2022125776A3 PCT/US2021/062606 US2021062606W WO2022125776A3 WO 2022125776 A3 WO2022125776 A3 WO 2022125776A3 US 2021062606 W US2021062606 W US 2021062606W WO 2022125776 A3 WO2022125776 A3 WO 2022125776A3
Authority
WO
WIPO (PCT)
Prior art keywords
age
compositions
methods
kidney diseases
treating kidney
Prior art date
Application number
PCT/US2021/062606
Other languages
French (fr)
Other versions
WO2022125776A2 (en
WO2022125776A8 (en
Inventor
Lewis S. Gruber
Original Assignee
Siwa Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siwa Corporation filed Critical Siwa Corporation
Priority to US18/265,205 priority Critical patent/US20240000930A1/en
Publication of WO2022125776A2 publication Critical patent/WO2022125776A2/en
Publication of WO2022125776A8 publication Critical patent/WO2022125776A8/en
Publication of WO2022125776A3 publication Critical patent/WO2022125776A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A method of treating or preventing the onset of kidney disease comprises administering to a subject a composition comprising an anti-AGE antibody. The anti- AGE antibody binds an AGE antigen comprising at least one protein or peptide that exhibits AGE modifications selected from the group consisting of FFI, pyrraline, AFGP, ALI, carboxymethyllysine, carboxyethyllysine and pentosidine. A method of treating or preventing the onset of kidney disease comprises administering to a subject a vaccine comprising an AGE antigen.
PCT/US2021/062606 2020-12-09 2021-12-09 Methods and compositions for treating kidney diseases WO2022125776A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US18/265,205 US20240000930A1 (en) 2020-12-09 2021-12-09 Methods and compositions for treating kidney diseases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063123326P 2020-12-09 2020-12-09
US63/123,326 2020-12-09

Publications (3)

Publication Number Publication Date
WO2022125776A2 WO2022125776A2 (en) 2022-06-16
WO2022125776A8 WO2022125776A8 (en) 2022-09-01
WO2022125776A3 true WO2022125776A3 (en) 2023-03-23

Family

ID=79601752

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2021/062606 WO2022125776A2 (en) 2020-12-09 2021-12-09 Methods and compositions for treating kidney diseases

Country Status (2)

Country Link
US (1) US20240000930A1 (en)
WO (1) WO2022125776A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9993535B2 (en) 2014-12-18 2018-06-12 Siwa Corporation Method and composition for treating sarcopenia
US10358502B2 (en) 2014-12-18 2019-07-23 Siwa Corporation Product and method for treating sarcopenia
WO2024102157A1 (en) * 2022-11-09 2024-05-16 Siwa Corporation Methods and compositions for treating diabetes and diabetic complications

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020023532A1 (en) * 2018-07-23 2020-01-30 Siwa Corporation Methods and compositions for treating chronic effects of radiation and chemical exposure

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US4217344A (en) 1976-06-23 1980-08-12 L'oreal Compositions containing aqueous dispersions of lipid spheres
US4917951A (en) 1987-07-28 1990-04-17 Micro-Pak, Inc. Lipid vesicles formed of surfactants and steroids
US4911928A (en) 1987-03-13 1990-03-27 Micro-Pak, Inc. Paucilamellar lipid vesicles
US5624804A (en) 1991-12-20 1997-04-29 The Rockefeller University Immunochemical detection of In vivo advanced glycosylation end products
US6387373B1 (en) 1993-01-15 2002-05-14 Novavax, Inc. Vaccines containing paucilsmellar lipid vesicles as immunological adjuvants
US6380165B1 (en) 1997-09-19 2002-04-30 The Picower Institute For Medical Research Immunological advanced glycation endproduct crosslink
WO2007056435A2 (en) 2005-11-08 2007-05-18 The General Hospital Corporation Dynamin mediated diseases and associated methods and products
US9144594B2 (en) 2005-11-08 2015-09-29 University Of Miami Cathepsin L mediated diseases and associated methods and products
WO2007098186A2 (en) 2006-02-22 2007-08-30 Novavax, Inc. Adjuvant and vaccine compositions
ES2457822T3 (en) 2007-11-08 2014-04-29 The General Hospital Corporation Procedures and compositions for treating proteinuric diseases
KR20120127543A (en) 2008-05-23 2012-11-21 시와 코퍼레이션 Methods, compositions and apparatus for facilitating regeneration
WO2010054167A2 (en) 2008-11-06 2010-05-14 University Of Miami Limited proteolysis of cd2ap and progression of renal disease
CA2779958A1 (en) 2008-11-06 2010-05-14 University Of Miami Role of soluble upar in the pathogenesis of proteinuric kidney disease
WO2011019980A1 (en) 2009-08-14 2011-02-17 University Of Miami Novel role of alpha-galactosidase activity as a biomarker in kidney disease
US9205135B2 (en) 2009-09-22 2015-12-08 University Of Miami Podocyte pH modulation and uses thereof
US20120251527A1 (en) 2009-11-06 2012-10-04 University Of Miami Podocyte specific assays and uses thereof
EP2608804A4 (en) 2010-08-27 2015-03-11 Univ Miami Treatment of renal diseases
ES2765006T3 (en) 2011-05-09 2020-06-05 The Univ Of Miami Reduction of soluble urokinase receptor in the circulation
US20140302065A1 (en) 2011-10-31 2014-10-09 The University Of Miami Soluble urokinase receptor (supar) in diabetic kidney disease
US10526579B2 (en) 2013-03-15 2020-01-07 Rush University Medical Center Podocyte cultures and uses thereof
EP3028044B1 (en) 2013-08-01 2019-06-19 The General Hospital Corporation Non-glycosylated supar biomarkers and uses thereof
CA2934250A1 (en) 2013-12-17 2015-06-25 Rush University Medical Center Compositions and methods for treating diabetic nephropathy
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JP2018514515A (en) 2015-03-27 2018-06-07 ラッシュ・ユニバーシティ・メディカル・センター Myeloid progenitor cells for kidney disease
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Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020023532A1 (en) * 2018-07-23 2020-01-30 Siwa Corporation Methods and compositions for treating chronic effects of radiation and chemical exposure

Also Published As

Publication number Publication date
WO2022125776A2 (en) 2022-06-16
WO2022125776A8 (en) 2022-09-01
US20240000930A1 (en) 2024-01-04

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