WO2022121056A1 - Continuous mass spectrum sample injection device and mass spectrum detection apparatus - Google Patents

Continuous mass spectrum sample injection device and mass spectrum detection apparatus Download PDF

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Publication number
WO2022121056A1
WO2022121056A1 PCT/CN2020/142334 CN2020142334W WO2022121056A1 WO 2022121056 A1 WO2022121056 A1 WO 2022121056A1 CN 2020142334 W CN2020142334 W CN 2020142334W WO 2022121056 A1 WO2022121056 A1 WO 2022121056A1
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Prior art keywords
sample
sample feeding
rotating wheel
mass spectrometry
belt
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PCT/CN2020/142334
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French (fr)
Chinese (zh)
Inventor
周鹏
陈剑松
洪义
黄保
杨俊林
刘越彪
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广州禾信仪器股份有限公司
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Publication of WO2022121056A1 publication Critical patent/WO2022121056A1/en

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components

Definitions

  • the invention relates to the field of mass spectrometry detection, in particular to a continuous mass spectrometry sample introduction device and mass spectrometry detection equipment.
  • In situ ionization mass spectrometry is an emerging mass spectrometry technology in the past ten years. Compared with traditional mass spectrometry methods, the most obvious difference between in situ ionization mass spectrometry technology is that it does not require complex sample pretreatment and pre-separation processes. It can only analyze the analyte, and has the characteristics of direct, rapid, real-time, in-situ, high-throughput, etc. It is especially suitable for the detection of large quantities of samples, and has been widely developed and applied in the fields of biology, environment, and food. .
  • the sampling devices commonly used in in-situ ionization mass spectrometry technology mostly use slide sampling, card sampling, distributed capillary, traveling sampling platform (such as 1 ⁇ 12 holes, 6 ⁇ 6 holes), etc., which can meet the requirements of a single Analysis of samples and multiple samples.
  • the above-mentioned sample introduction device still has the following defects: 1. The amount of samples that can be loaded is small, and the sample loading device needs to be manually replaced frequently, which cannot meet the continuous detection of large batches of samples. 2. The degree of automation is low, and it is difficult to realize the programmed detection process. 3. The degree of isolation between samples is low, which is prone to cross-contamination. 4. There are many manual intervention operations, which are prone to human errors.
  • a continuous mass spectrometry sampling device comprising a sample feeding mechanism, a sample spotting mechanism and a position detection mechanism; a plurality of sample feeding grooves are sequentially arranged on the sample feeding mechanism, and the sample feeding mechanism has a sample feeding end and a recovery end , the sample feeding mechanism is used to transport the sample feeding groove to the detection area of the mass spectrometry detection device, and the sampling mechanism is arranged above the sample feeding end for adding the sample feeding groove to each of the sample feeding grooves.
  • the position detection mechanism is arranged at a predetermined position for detecting whether the sample in the sample feeding slot reaches the detection area of the mass spectrometry detection device and sends a sample feeding suspension signal to the sample feeding mechanism.
  • the sample feeding mechanism includes a sample feeding belt and a sample feeding driving part, the sample feeding belt is provided with a plurality of sample feeding grooves arranged in sequence, and the sample feeding driving part is connected to the The sample feeding belt is used for driving the movement of the sample feeding belt.
  • the sample feeding mechanism further includes a first rotating wheel and a second rotating wheel, the first rotating wheel and the second rotating wheel are arranged opposite to each other, the first rotating wheel and the second rotating wheel Two rotating wheels are connected through the sample feeding belt, and the sample feeding driving part is connected to the first rotating wheel and/or the second rotating wheel for driving the first rotating wheel and the second rotating wheel The rotating wheel rotates, the first rotating wheel is used to place the unloaded part of the sample feeding belt, and the second rotating wheel is used to wind up the part of the sample feeding belt that has been loaded and has been detected by mass spectrometry .
  • the sample feeding mechanism further includes a pressing wheel, the pressing wheel is arranged opposite to the second rotating wheel, the pressing wheel is movably arranged, and the pressure wheel is arranged between the pressing wheel and the second rotating wheel.
  • the pressing wheel is matched with the second rotating wheel to assist the second rotating wheel to wind up the part of the sample feeding belt that has been loaded and detected by mass spectrometry .
  • the sample feeding driving part is connected to the second rotating wheel.
  • the continuous mass spectrometry sampling device further includes a tensioning mechanism, the tensioning mechanism includes at least two tensioning limit posts, the tensioning and limiting posts are arranged between the first rotating wheel and the first rotating wheel. Between the second rotating wheels, the tension limit post is used for tensioning the sample feeding belt.
  • the sample feeding grooves on the sample feeding belt are sequentially distributed along the length direction of the sample feeding belt, and the adjacent sample feeding grooves on the sample feeding belt There are intervals between the grooves, and the intervals between the adjacent sample feeding grooves are equal.
  • the distance between the spotting mechanism and the position detection mechanism is equal to the distance between adjacent sample feeding slots.
  • a mass spectrometry detection device includes the continuous mass spectrometry sampling device.
  • the sample feeding mechanism drives the sample feeding belt to move a preset distance, which can make the sample feeding groove on the sample feeding belt move to the spotting mechanism, and the sample feeding mechanism adds samples to the sample feeding groove.
  • the rear sample feeding mechanism drives the sample feeding belt to move to the position detection mechanism.
  • the position detection mechanism detects that the sample in the sample feeding slot reaches the detection area of the mass spectrometry detection device, the position detection mechanism sends the sample feeding mechanism a signal to suspend sample feeding , the sample feeding mechanism stops driving the sample feeding belt to move, and the sample is detected by the mass spectrometry detection device here.
  • the continuous mass spectrometry sample introduction device of the present invention realizes the actions of automatic sample addition and automatic sample introduction, has a high degree of automation, reduces manual participation, and improves detection efficiency.
  • the continuous mass spectrometry sampling device of the present invention sets an interval between adjacent sample feeding slots, and also sets an interval between the spotting mechanism and the position detection mechanism, which can effectively reduce or eliminate the sample cross-contamination.
  • FIG. 1 is a schematic diagram of the continuous mass spectrometry sampling device according to Embodiment 1 of the present invention.
  • FIG. 2 is a schematic diagram of the continuous mass spectrometry sampling device described in Example 2 of the present invention.
  • Continuous mass spectrometry sampling device 100, sample feeding mechanism; 110, sample feeding belt; 120, first rotating wheel; 130, second rotating wheel; 140, pressing wheel; 200, spotting mechanism; 300, position Detection mechanism; 400, tensioning mechanism; 410, tensioning limit post.
  • first, second, etc. are used in the present invention to describe various information, but these information should not be limited to these terms, which are only used to distinguish the same type of information from each other.
  • first information may also be referred to as “second” information
  • second information may also be referred to as “first” information, without departing from the scope of the present invention.
  • connection should be understood in a broad sense, for example, it may be a fixed connection, a detachable connection, or an integral connection.
  • ground connection may be mechanical connection or electrical connection; may be directly connected or indirectly connected through an intermediary, may be internal communication between two elements, that is, when an element is said to be “fixed to” another element, it may be directly on another element or there may be an intervening element.
  • an element is referred to as being “connected” to another element, it can be directly connected to the other element or intervening elements may also be present.
  • the specific meanings of the above terms in the present invention can be understood in specific situations.
  • an embodiment of the present invention provides a continuous mass spectrometry sample introduction device 10 .
  • a continuous mass spectrometry sample introduction device 10 includes a sample feeding mechanism 100 , a sample spotting mechanism 200 and a position detection mechanism 300 .
  • the sample feeding mechanism 100 is sequentially provided with a plurality of sample feeding grooves.
  • the sample feeding mechanism 100 has a sample adding end and a recovery end.
  • the sample feeding mechanism 100 can transport the sample feeding tank to the detection area of the mass spectrometry detection device.
  • the sample spotting mechanism 200 is arranged above the sample adding end for adding samples to each sample feeding slot.
  • the position detection mechanism 300 is arranged at a predetermined position for detecting whether the sample in the sample feeding tank reaches the detection area of the mass spectrometry detection device and sends a sample feeding suspension signal to the sample feeding mechanism 100 .
  • the sample feeding mechanism 100 includes a sample feeding belt 110 and a sample feeding driving component.
  • the sample feeding drive components are not shown in FIG. 1 and FIG. 2 .
  • the sample feeding belt 110 is provided with a plurality of sample feeding grooves arranged in sequence.
  • the sample feeding grooves are arranged on the front side of the sample feeding belt 110. In the direction shown in FIG. 1, the sample feeding grooves are located in the sample feeding grooves.
  • the upper surface of the belt 110 .
  • the sample feeding driving part is connected to the sample feeding belt 110 for driving the sample feeding belt 110 to move.
  • the sample feeding drive component may be a drive motor. During sample injection, continuous sample feeding can be achieved through the sample feeding belt 110, which can meet the continuous detection of large batches of samples.
  • the sample feeding mechanism 100 drives the sample feeding belt 110 to move a preset distance, which can make the sample feeding.
  • the sample feeding slot on the sample belt 110 moves to the spotting mechanism 200, and the spotting mechanism 200 adds samples to the sample feeding slot.
  • the sample feeding mechanism 100 drives the sample feeding belt 110 to move to the position detection mechanism 300.
  • the position detection mechanism 300 detects that the sample in the sample feeding tank reaches the detection area of the mass spectrometry detection device, the position detection mechanism 300 sends a sample feeding suspension signal to the sample feeding mechanism 100, and the sample feeding mechanism 100 stops driving the sample feeding belt 110 moves, where the sample is detected by mass spectrometry detection equipment.
  • the sample feeding mechanism 100 further includes a first rotating wheel 120 and a second rotating wheel 130 .
  • the first rotating wheel 120 is disposed opposite to the second rotating wheel 130 .
  • the first rotating wheel 120 and the second rotating wheel 130 are connected by the sample feeding belt 110, and the sample feeding driving component is connected to the first rotating wheel 120 and/or the second rotating wheel 130 for driving the first rotating wheel 120 and the second rotating wheel 130.
  • the rotating wheel 130 rotates.
  • the first rotating wheel 120 is used for winding up the unsampled part of the sample feeding belt 110
  • the second rotating wheel 130 is used for winding up the part of the sample feeding belt 110 that has been loaded and detected by mass spectrometry.
  • the whole roll of the sample feeding belt 110 can be sleeved on the first rotating wheel 120, and the head of the sample feeding belt 110 is drawn to the second rotating wheel 120 when in use.
  • the sample feeding driving component drives the second rotating wheel 130 to rotate, it can drive the sample feeding belt 110 on the first rotating wheel 120 to release.
  • the sample feeding mechanism 100 further includes a pressing wheel 140 .
  • the pressing wheel 140 is arranged opposite to the second rotating wheel 130, the pressing wheel 140 is arranged movably, there is a gap between the pressing wheel 140 and the second rotating wheel 130 for the sample feeding belt 110 to pass through, and the pressing wheel 140 is matched with the second rotating wheel 130.
  • the wheel 130 is used to assist the second rotating wheel 130 to wind up the portion of the sample feeding belt 110 that has been loaded and detected by mass spectrometry.
  • the sample feeding driving part is connected to the second rotating wheel 130 .
  • the first rotating wheel 120 serves as a driven wheel for cooperative sample feeding.
  • the continuous mass spectrometry sample introduction device 10 further includes a tensioning mechanism 400 .
  • the tensioning mechanism 400 includes at least two tensioning limit posts 410 .
  • the tensioning and limiting posts 410 are disposed between the first rotating wheel 120 and the second rotating wheel 130 , and the tensioning and limiting posts 410 are used for tensioning the sample feeding. Take 110. Referring to the direction shown in FIG. 1 , in the height direction, the position of the tension limit post 410 is a little higher than the positions of the first rotating wheel 120 and the position of the second rotating wheel 130 to ensure that the two tension limit posts 410 can be stretched Tighten the sample feeding belt 110.
  • the sample feeding slots on the sample feeding belt 110 are sequentially distributed along the length direction of the sample feeding belt 110 .
  • the adjacent sample feeding grooves on the sample feeding belt 110 are spaced apart, and the spacings between adjacent sample feeding grooves are equal. Since the distances between adjacent sample feeding slots are equal, the consistency of sample injection positions can be ensured, and human errors can be reduced.
  • an interval is set between adjacent sample feeding slots, and an interval is also set between the spotting mechanism 200 and the position detection mechanism 300, which can effectively reduce or eliminate the gap between samples of cross-contamination.
  • the distance between the spotting mechanism 200 and the position detection mechanism 300 is equal to the distance between adjacent sample feeding slots.
  • the continuous mass spectrometry sample introduction device 10 further includes a support, wherein the spotting mechanism 200 and the position detection mechanism 300 are arranged on the support.
  • the first rotating wheel 120, the second rotating wheel 130 and the tensioning limit post 410 are all arranged on the bracket.
  • the entire continuous mass spectrometer sampling device 10 is integrated on one bracket, which is convenient for the connection with the mass spectrometry detection equipment. installation between.
  • the brackets are not shown in both Figures 1 and 2 .
  • An embodiment of the present invention provides a mass spectrometry detection device.
  • a mass spectrometry detection device includes the above-mentioned continuous mass spectrometry sampling device 10 .
  • This embodiment provides a continuous mass spectrometry sampling device 10 .
  • a continuous mass spectrometry sample introduction device 10 includes a sample feeding mechanism 100 , a sample spotting mechanism 200 , a tensioning mechanism 400 and a position detecting mechanism 300 .
  • the sample feeding mechanism 100 is sequentially provided with a plurality of sample feeding grooves.
  • the sample feeding slots on the sample feeding belt 110 are sequentially distributed along the length direction of the sample feeding belt 110 .
  • the adjacent sample feeding grooves on the sample feeding belt 110 are spaced apart, and the spacings between adjacent sample feeding grooves are equal.
  • the sample feeding mechanism 100 has a sample adding end and a recovery end.
  • the sample feeding mechanism 100 can transport the sample feeding tank to the detection area of the mass spectrometry detection device.
  • the sample spotting mechanism 200 is arranged above the sample adding end for adding samples to each sample feeding slot.
  • the position detection mechanism 300 is arranged at a predetermined position and is used to detect whether the sample in the sample feeding tank reaches the detection area of the mass spectrometry detection device and send a sample feeding suspension signal to the sample feeding mechanism 100 .
  • the position detection mechanism 300 detects that the sample in the sample feeding slot reaches the detection area of the mass spectrometry detection device, the position detection mechanism 300 sends a sample feeding suspension signal to the sample feeding mechanism 100, and the sample feeding mechanism 100 stops driving the sample feeding belt 110 to move. , where the sample is detected by mass spectrometry detection equipment.
  • the spacing between the spotting mechanism 200 and the position detecting mechanism 300 is equal to the spacing between adjacent sample feeding slots.
  • the sample feeding mechanism 100 includes a sample feeding belt 110 and a sample feeding driving part.
  • the sample feeding belt 110 is provided with a plurality of sample feeding grooves arranged in sequence, and the sample feeding driving component is connected to the sample feeding belt 110 for driving the sample feeding belt 110 to move.
  • the sample feeding drive part is a drive motor.
  • the sample feeding mechanism 100 further includes a first rotating wheel 120 and a second rotating wheel 130 .
  • the first rotating wheel 120 is disposed opposite to the second rotating wheel 130 .
  • the first rotating wheel 120 and the second rotating wheel 130 are connected by the sample feeding belt 110
  • the sample feeding driving component is connected to the second rotating wheel 130 for driving the first rotating wheel 120 and the second rotating wheel 130 to rotate.
  • the first rotating wheel 120 is used for winding up the unsampled part of the sample feeding belt 110
  • the second rotating wheel 130 is used for winding up the part of the sample feeding belt 110 that has been loaded and detected by mass spectrometry.
  • the sample feeding mechanism 100 further includes a pressing wheel 140 .
  • the pressing wheel 140 is arranged opposite to the second rotating wheel 130, the pressing wheel 140 is arranged movably, there is a gap between the pressing wheel 140 and the second rotating wheel 130 for the sample feeding belt 110 to pass through, and the pressing wheel 140 is matched with the second rotating wheel 130.
  • the wheel 130 is used to assist the second rotating wheel 130 to wind up the portion of the sample feeding belt 110 that has been loaded and detected by mass spectrometry.
  • the tensioning mechanism 400 includes two tensioning limiting posts 410, the two tensioning limiting posts 410 are disposed between the first rotating wheel 120 and the second rotating wheel 130, and one of the tensioning limiting posts 410 is close to the first rotating wheel 120 and the second rotating wheel 130.
  • One rotating wheel 120, another tensioning limit post 410 is close to the second rotating wheel 130, and the tensioning limit post 410 is used to support and tension the sample feeding belt 110, so as to facilitate sample loading and position detection of the spotting mechanism 200 Detection of the mechanism 300 .
  • This embodiment provides a continuous mass spectrometry sampling device 10 .
  • a continuous mass spectrometry sample introduction device 10 includes a sample feeding mechanism 100 , a sample spotting mechanism 200 and a position detection mechanism 300 .
  • the sample feeding mechanism 100 is sequentially provided with a plurality of sample feeding grooves.
  • the sample feeding slots on the sample feeding belt 110 are sequentially distributed along the length direction of the sample feeding belt 110 .
  • the adjacent sample feeding grooves on the sample feeding belt 110 are spaced apart, and the spacings between adjacent sample feeding grooves are equal.
  • the sample feeding mechanism 100 has a sample adding end and a recovery end.
  • the sample feeding mechanism 100 can transport the sample feeding tank to the detection area of the mass spectrometry detection device.
  • the sample spotting mechanism 200 is arranged above the sample adding end for adding samples to each sample feeding slot.
  • the position detection mechanism 300 is arranged at a predetermined position and is used to detect whether the sample in the sample feeding tank reaches the detection area of the mass spectrometry detection device and send a sample feeding suspension signal to the sample feeding mechanism 100 .
  • the position detection mechanism 300 detects that the sample in the sample feeding slot reaches the detection area of the mass spectrometry detection device, the position detection mechanism 300 sends a sample feeding suspension signal to the sample feeding mechanism 100, and the sample feeding mechanism 100 stops driving the sample feeding belt 110 to move. , where the sample is detected by mass spectrometry detection equipment.
  • the spacing between the spotting mechanism 200 and the position detecting mechanism 300 is equal to the spacing between adjacent sample feeding slots.
  • the sample feeding mechanism 100 includes a sample feeding belt 110 and a sample feeding driving part.
  • the sample feeding belt 110 is provided with a plurality of sample feeding grooves arranged in sequence, and the sample feeding driving component is connected to the sample feeding belt 110 for driving the sample feeding belt 110 to move.
  • the sample feeding drive part is a drive motor.
  • the sample feeding mechanism 100 further includes a first rotating wheel 120 , a second rotating wheel 130 and a pressing wheel 140 .
  • the first rotating wheel 120 is disposed opposite to the second rotating wheel 130 .
  • the first rotating wheel 120 and the second rotating wheel 130 are connected by the sample feeding belt 110
  • the sample feeding driving component is connected to the second rotating wheel 130 for driving the first rotating wheel 120 and the second rotating wheel 130 to rotate.
  • the first rotating wheel 120 is used for winding up the unsampled portion of the sample feeding belt 110
  • the second rotating wheel 130 is used for winding up the portion of the sample feeding belt 110 that has been loaded and detected by mass spectrometry.
  • the pressing wheel 140 is arranged opposite to the second rotating wheel 130 , the pressing wheel 140 is movably arranged, and there is a gap between the pressing wheel 140 and the second rotating wheel 130 for the sample feeding belt 110 to pass through.
  • the 140 is matched with the second rotating wheel 130 to assist the second rotating wheel 130 to take up the part of the sample feeding belt 110 after the sample is loaded and has been detected by mass spectrometry.
  • the pressing wheel 140 is used to press the sample feeding belt on the second rotating wheel 130. 110.
  • the tensioning mechanism 400 includes two tensioning limiting posts 410, the two tensioning limiting posts 410 are disposed between the first rotating wheel 120 and the second rotating wheel 130, and one of the tensioning limiting posts 410 is close to the first rotating wheel 120 and the second rotating wheel 130.
  • One rotating wheel 120, another tensioning limit post 410 is close to the second rotating wheel 130, and the tensioning limit post 410 is used to support and tension the sample feeding belt 110, so as to facilitate sample loading and position detection of the spotting mechanism 200 Detection of the mechanism 300 .
  • the continuous mass spectrometry sample introduction device 10 of the present invention has the following beneficial effects:
  • the sample feeding belt 110 can realize continuous sample feeding, which can meet the continuous detection of large batches of samples.
  • the sample feeding mechanism 100 drives the sample feeding belt 110 to move a preset distance, which can make the sample feeding slot on the sample feeding belt 110 move to the spotting mechanism 200, and the spotting mechanism 200 moves to the sample feeding slot.
  • the sample feeding mechanism 100 drives the sample feeding belt 110 to move to the position detection mechanism 300.
  • the position detection mechanism 300 detects that the sample in the sample feeding slot reaches the detection area of the mass spectrometry detection device, the position The detection mechanism 300 sends a sample feeding suspension signal to the sample feeding mechanism 100, and the sample feeding mechanism 100 stops driving the sample feeding belt 110 to move, where the sample is detected by the mass spectrometry detection device.
  • the continuous mass spectrometry sample introduction device 10 of the present invention realizes the actions of automatic sample addition and automatic sample introduction, and has a high degree of automation, reduces manual participation, and improves detection efficiency.
  • an interval is set between adjacent sample feeding slots, and an interval is also set between the spotting mechanism 200 and the position detection mechanism 300, which can effectively reduce the Or eliminate cross-contamination between samples.

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Abstract

A continuous mass spectrum sample injection device (10) and a mass spectrum detection apparatus. The continuous mass spectrum sample injection device comprises a sample conveying mechanism (100), a sample application mechanism (200) and a position detection mechanism (300), wherein a plurality of sample conveying cells are sequentially arranged on the sample conveying mechanism (100); the sample conveying mechanism (100) is provided with a sample adding end and a recycling end; the sample conveying mechanism (100) can convey the sample conveying cells to a detection region of a mass spectrum detection apparatus; the sample application mechanism (200) is arranged above the sample adding end and is used for adding samples into each sample conveying cell; and the position detection mechanism (300) is arranged at a pre-set position and is used for detecting whether the samples in the sample conveying cells reach the detection region of the mass spectrum detection apparatus, and for sending a sample conveying suspension signal to the sample conveying mechanism (100). When the continuous mass spectrum sample injection device (10) is used for mass spectrum sample injection, a sample-carrying stage does not need to be frequently replaced, and the device can satisfy the continuous detection of a large batch of samples; the consistency of sample injection positions can be ensured, and personal errors are reduced; automatic sampling and sample injection processes can be realized; and cross contamination among the samples can be effectively reduced or eliminated.

Description

连续式质谱进样装置以及质谱检测设备Continuous mass spectrometry sampling device and mass spectrometry detection equipment 技术领域technical field
本发明涉及质谱检测领域，特别是涉及一种连续式质谱进样装置以及质谱检测设备。The invention relates to the field of mass spectrometry detection, in particular to a continuous mass spectrometry sample introduction device and mass spectrometry detection equipment.
背景技术Background technique
原位电离质谱技术是近十几年来新兴的质谱技术，与传统质谱方法相比，原位电离质谱技术最明显的区别就是无需复杂的样品前处理和预分离过程，直接在常压环境下即可对待测物只进行分析，具有直接、快速、实时、原位、高通量等特点，特别适用于大批量样品的检测，已在在生物、环境、食品等领域得到了广泛的发展和应用。In situ ionization mass spectrometry is an emerging mass spectrometry technology in the past ten years. Compared with traditional mass spectrometry methods, the most obvious difference between in situ ionization mass spectrometry technology is that it does not require complex sample pretreatment and pre-separation processes. It can only analyze the analyte, and has the characteristics of direct, rapid, real-time, in-situ, high-throughput, etc. It is especially suitable for the detection of large quantities of samples, and has been widely developed and applied in the fields of biology, environment, and food. .
目前原位电离质谱技术常用的进样装置多采用载玻片进样、卡片进样、分布式毛细管、行进式进样台(如1×12孔、6×6孔)等，可分别满足单个样品及多个样品的分析。但是，面对市场上日益庞大的检测量需求，上述的进样装置还存在着以下的缺陷：1、可承载样品量少，需要人工频繁更换载样装置，无法满足大批量样品的连续检测。2、自动化程度低，较难实现程序化检测流程。3、样品间隔离程度低，易产生交叉污染。4、人工介入操作较多，易产生人为误差。At present, the sampling devices commonly used in in-situ ionization mass spectrometry technology mostly use slide sampling, card sampling, distributed capillary, traveling sampling platform (such as 1 × 12 holes, 6 × 6 holes), etc., which can meet the requirements of a single Analysis of samples and multiple samples. However, in the face of the increasing demand for detection volume in the market, the above-mentioned sample introduction device still has the following defects: 1. The amount of samples that can be loaded is small, and the sample loading device needs to be manually replaced frequently, which cannot meet the continuous detection of large batches of samples. 2. The degree of automation is low, and it is difficult to realize the programmed detection process. 3. The degree of isolation between samples is low, which is prone to cross-contamination. 4. There are many manual intervention operations, which are prone to human errors.
发明内容SUMMARY OF THE INVENTION
基于此，有必要提供一种连续式质谱进样装置。本发明的连续式质谱进样装置用于质谱进样时，无需频繁更换载样台，可满足大批量样品的连续检测；可保证样品进样位置的一致性，减小了人为误差；可实现自动取样、进样过程；可有效减小或消除样品间的交叉污染。Based on this, it is necessary to provide a continuous mass spectrometry sampling device. When the continuous mass spectrometry sampling device of the present invention is used for mass spectrometry sampling, there is no need to frequently replace the sample stage, which can meet the continuous detection of large batches of samples; the consistency of the sampling position of the samples can be ensured, and the human error can be reduced; Automatic sampling and injection process; can effectively reduce or eliminate cross-contamination between samples.
一种连续式质谱进样装置，包括送样机构、点样机构以及位置检测机构；所述送样机构上顺序设置有多个样品送样槽，所述送样机构具有加样端以及回收端，所述送样机构用于将所述样品送样槽输送至质谱检测设备的检测区域， 所述点样机构设置在所述加样端的上方以用于向各个所述样品送样槽内加样，所述位置检测机构设置在预定位置以用于检测所述样品送样槽中的样品是否到达质谱检测设备的检测区域并给送样机构发送暂停送样信号。A continuous mass spectrometry sampling device, comprising a sample feeding mechanism, a sample spotting mechanism and a position detection mechanism; a plurality of sample feeding grooves are sequentially arranged on the sample feeding mechanism, and the sample feeding mechanism has a sample feeding end and a recovery end , the sample feeding mechanism is used to transport the sample feeding groove to the detection area of the mass spectrometry detection device, and the sampling mechanism is arranged above the sample feeding end for adding the sample feeding groove to each of the sample feeding grooves. For example, the position detection mechanism is arranged at a predetermined position for detecting whether the sample in the sample feeding slot reaches the detection area of the mass spectrometry detection device and sends a sample feeding suspension signal to the sample feeding mechanism.
在其中一个实施例中，所述送样机构包括样品送样带以及送样驱动部件，所述样品送样带上设置有多个顺序排列的样品送样槽，所述送样驱动部件连接于所述样品送样带以用于驱动所述样品送样带运动。In one embodiment, the sample feeding mechanism includes a sample feeding belt and a sample feeding driving part, the sample feeding belt is provided with a plurality of sample feeding grooves arranged in sequence, and the sample feeding driving part is connected to the The sample feeding belt is used for driving the movement of the sample feeding belt.
在其中一个实施例中，所述送样机构还包括第一转动轮以及第二转动轮，所述第一转动轮与所述第二转动轮相对设置，所述第一转动轮以及所述第二转动轮通过所述样品送样带连接，所述送样驱动部件连接于所述第一转动轮和/或所述第二转动轮以用于驱动所述第一转动轮和所述第二转动轮转动，所述第一转动轮用于放置所述样品送样带未加样的部分，所述第二转动轮用于卷取所述样品送样带加样后且已质谱检测的部分。In one embodiment, the sample feeding mechanism further includes a first rotating wheel and a second rotating wheel, the first rotating wheel and the second rotating wheel are arranged opposite to each other, the first rotating wheel and the second rotating wheel Two rotating wheels are connected through the sample feeding belt, and the sample feeding driving part is connected to the first rotating wheel and/or the second rotating wheel for driving the first rotating wheel and the second rotating wheel The rotating wheel rotates, the first rotating wheel is used to place the unloaded part of the sample feeding belt, and the second rotating wheel is used to wind up the part of the sample feeding belt that has been loaded and has been detected by mass spectrometry .
在其中一个实施例中，所述送样机构还包括压轮，所述压轮与所述第二转动轮相对设置，所述压轮活动设置，所述压轮与所述第二转动轮之间具有用于供样品送样带通过的间隙，所述压轮配合于所述第二转动轮以辅助所述第二转动轮卷取所述样品送样带加样后且已质谱检测的部分。In one embodiment, the sample feeding mechanism further includes a pressing wheel, the pressing wheel is arranged opposite to the second rotating wheel, the pressing wheel is movably arranged, and the pressure wheel is arranged between the pressing wheel and the second rotating wheel. There is a gap for the sample feeding belt to pass through, and the pressing wheel is matched with the second rotating wheel to assist the second rotating wheel to wind up the part of the sample feeding belt that has been loaded and detected by mass spectrometry .
在其中一个实施例中，所述送样驱动部件连接于所述第二转动轮。In one of the embodiments, the sample feeding driving part is connected to the second rotating wheel.
在其中一个实施例中，所述连续式质谱进样装置还包括张紧机构，所述张紧机构包括至少两个张紧限位柱，所述张紧限位柱设置在第一转动轮与所述第二转动轮之间，所述张紧限位柱用于张紧所述样品送样带。In one embodiment, the continuous mass spectrometry sampling device further includes a tensioning mechanism, the tensioning mechanism includes at least two tensioning limit posts, the tensioning and limiting posts are arranged between the first rotating wheel and the first rotating wheel. Between the second rotating wheels, the tension limit post is used for tensioning the sample feeding belt.
在其中一个实施例中，所述样品送样带上的所述样品送样槽沿着所述样品送样带的长度方向顺序分布，所述样品送样带上相邻的所述样品送样槽之间具有间隔且相邻的所述样品送样槽之间的间距相等。In one embodiment, the sample feeding grooves on the sample feeding belt are sequentially distributed along the length direction of the sample feeding belt, and the adjacent sample feeding grooves on the sample feeding belt There are intervals between the grooves, and the intervals between the adjacent sample feeding grooves are equal.
在其中一个实施例中，所述点样机构与所述位置检测机构之间具有间隔。In one of the embodiments, there is a gap between the spotting mechanism and the position detecting mechanism.
在其中一个实施例中，所述点样机构与所述位置检测机构之间的间距等于相邻的样品送样槽之间的间距。In one embodiment, the distance between the spotting mechanism and the position detection mechanism is equal to the distance between adjacent sample feeding slots.
一种质谱检测设备，包括所述的连续式质谱进样装置。A mass spectrometry detection device includes the continuous mass spectrometry sampling device.
本发明的连续式质谱进样装置具有如下有益效果：The continuous mass spectrometry sampling device of the present invention has the following beneficial effects:
(1)、本发明的连续式质谱进样装置用于质谱进样时，无需频繁更换载样台，通过样品送样带可实现连续送样，可满足大批量样品的连续检测，在检测时，送样机构驱动样品送样带移动预设距离，该距离能够使得样品送样带上的样品送样槽移动至点样机构处，点样机构向样品送样槽内加样，加样完毕后送样机构驱动样品送样带移动至位置检测机构处，当位置检测机构检测到样品送样槽中的样品到达质谱检测设备的检测区域时，位置检测机构给送样机构发送暂停送样信号，送样机构停止驱动样品送样带移动，样品在此处被质谱检测设备检测。(1) When the continuous mass spectrometry sampling device of the present invention is used for mass spectrometry sampling, there is no need to frequently replace the sample stage, and continuous sample feeding can be realized through the sample feeding belt, which can meet the continuous detection of large batches of samples. , the sample feeding mechanism drives the sample feeding belt to move a preset distance, which can make the sample feeding groove on the sample feeding belt move to the spotting mechanism, and the sample feeding mechanism adds samples to the sample feeding groove. The rear sample feeding mechanism drives the sample feeding belt to move to the position detection mechanism. When the position detection mechanism detects that the sample in the sample feeding slot reaches the detection area of the mass spectrometry detection device, the position detection mechanism sends the sample feeding mechanism a signal to suspend sample feeding , the sample feeding mechanism stops driving the sample feeding belt to move, and the sample is detected by the mass spectrometry detection device here.
(2)、本发明的连续式质谱进样装置中，由于相邻的样品送样槽之间的间距均相等，可保证样品进样位置的一致性，减小了人为误差。(2) In the continuous mass spectrometry sampling device of the present invention, since the distances between adjacent sample feeding slots are equal, the consistency of the sampling positions of the samples can be ensured, and the human error can be reduced.
(3)本发明的连续式质谱进样装置实现了自动加样、自动进样的动作，自动化程度高，减少了人工参与，提高了检测效率。(3) The continuous mass spectrometry sample introduction device of the present invention realizes the actions of automatic sample addition and automatic sample introduction, has a high degree of automation, reduces manual participation, and improves detection efficiency.
(4)、本发明的连续式质谱进样装置在相邻的样品送样槽之间设置了间隔，且在点样机构与位置检测机构之间也设置了间隔，可有效减小或消除样品间的交叉污染。(4) The continuous mass spectrometry sampling device of the present invention sets an interval between adjacent sample feeding slots, and also sets an interval between the spotting mechanism and the position detection mechanism, which can effectively reduce or eliminate the sample cross-contamination.
附图说明Description of drawings
图1为本发明实施例1所述的连续式质谱进样装置示意图；FIG. 1 is a schematic diagram of the continuous mass spectrometry sampling device according to Embodiment 1 of the present invention;
图2为本发明实施例2所述的连续式质谱进样装置示意图。FIG. 2 is a schematic diagram of the continuous mass spectrometry sampling device described in Example 2 of the present invention.
附图标记说明Description of reference numerals
10、连续式质谱进样装置；100、送样机构；110、样品送样带；120、第一转动轮；130、第二转动轮；140、压轮；200、点样机构；300、位置检测机构；400、张紧机构；410、张紧限位柱。10. Continuous mass spectrometry sampling device; 100, sample feeding mechanism; 110, sample feeding belt; 120, first rotating wheel; 130, second rotating wheel; 140, pressing wheel; 200, spotting mechanism; 300, position Detection mechanism; 400, tensioning mechanism; 410, tensioning limit post.
具体实施方式Detailed ways
为了便于理解本发明，下面将参照相关附图对本发明进行更全面的描述。附图中给出了本发明的较佳实施例。但是，本发明可以以许多不同的形式来实现，并不限于本文所描述的实施例。相反地，提供这些实施例的目的是使对本 发明的公开内容的理解更加透彻全面。In order to facilitate understanding of the present invention, the present invention will be described more fully hereinafter with reference to the related drawings. Preferred embodiments of the invention are shown in the accompanying drawings. However, the present invention may be embodied in many different forms and is not limited to the embodiments described herein. Rather, these embodiments are provided so that a thorough and complete understanding of the present disclosure will be provided.
在本发明的描述中，应当理解的是，本发明中采用术语在本发明的描述中，应当理解的是，本发明中采用术语“中心”、“上”、“下”、“底”、“内”、“外”等指示的方位或位置关系为基于附图所示的方位或位置关系，仅是为了便于描述本发明和简化描述，而不是指示或暗示所指的装置或元件必须具有特定的方位、以特定的方位构造和操作，因此不能理解为对本发明的限制。In the description of the present invention, it should be understood that the terms used in the present invention The orientation or positional relationship indicated by "inside", "outside", etc. is based on the orientation or positional relationship shown in the drawings, which is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the indicated device or element must have The particular orientation, construction and operation in the particular orientation are therefore not to be construed as limitations of the invention.
应当理解的是，本发明中采用术语“第一”、“第二”等来描述各种信息，但这些信息不应限于这些术语，这些术语仅用来将同一类型的信息彼此区分开。例如，在不脱离本发明范围的情况下，“第一”信息也可以被称为“第二”信息，类似的，“第二”信息也可以被称为“第一”信息。It should be understood that the terms "first", "second", etc. are used in the present invention to describe various information, but these information should not be limited to these terms, which are only used to distinguish the same type of information from each other. For example, "first" information may also be referred to as "second" information, and similarly, "second" information may also be referred to as "first" information, without departing from the scope of the present invention.
在本发明的描述中，需要说明的是，除非另有明确的规定和限定，术语“相连”、“连接”应做广义理解，例如，可以是固定连接，也可以是可拆卸连接，或一体地连接；可以是机械连接，也可以是电连接；可以是直接相连，也可以通过中间媒介间接相连，可以是两个元件内部的连通，也即，当元件被称为“固定于”另一个元件，它可以直接在另一个元件上或者也可以存在居中的元件。当一个元件被认为是“连接”另一个元件，它可以是直接连接到另一个元件或者可能同时存在居中元件。对于本领域的普通技术人员而言，可以具体情况理解上述术语在本发明中的具体含义。In the description of the present invention, it should be noted that, unless otherwise expressly specified and limited, the terms "connected" and "connected" should be understood in a broad sense, for example, it may be a fixed connection, a detachable connection, or an integral connection. ground connection; may be mechanical connection or electrical connection; may be directly connected or indirectly connected through an intermediary, may be internal communication between two elements, that is, when an element is said to be "fixed to" another element, it may be directly on another element or there may be an intervening element. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood in specific situations.
除非另有定义，本文所使用的所有的技术和科学术语与属于本发明的技术领域的技术人员通常理解的含义相同。本文中在本发明的说明书中所使用的术语只是为了描述具体的实施例的目的，不是旨在于限制本发明。本文所使用的术语“和/或”包括一个或多个相关的所列项目的任意的和所有的组合。Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terms used herein in the description of the present invention are for the purpose of describing specific embodiments only, and are not intended to limit the present invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
请参阅图1所示，本发明一实施例提供了一种连续式质谱进样装置10。Referring to FIG. 1 , an embodiment of the present invention provides a continuous mass spectrometry sample introduction device 10 .
一种连续式质谱进样装置10，包括送样机构100、点样机构200以及位置检测机构300。A continuous mass spectrometry sample introduction device 10 includes a sample feeding mechanism 100 , a sample spotting mechanism 200 and a position detection mechanism 300 .
送样机构100上顺序设置有多个样品送样槽。送样机构100具有加样端以及回收端。送样机构100能够将样品送样槽输送至质谱检测设备的检测区域。The sample feeding mechanism 100 is sequentially provided with a plurality of sample feeding grooves. The sample feeding mechanism 100 has a sample adding end and a recovery end. The sample feeding mechanism 100 can transport the sample feeding tank to the detection area of the mass spectrometry detection device.
点样机构200设置在加样端的上方以用于向各个样品送样槽内加样。The sample spotting mechanism 200 is arranged above the sample adding end for adding samples to each sample feeding slot.
位置检测机构300设置在预定位置以用于检测所述样品送样槽中的样品是否到达质谱检测设备的检测区域并给送样机构100发送暂停送样信号。The position detection mechanism 300 is arranged at a predetermined position for detecting whether the sample in the sample feeding tank reaches the detection area of the mass spectrometry detection device and sends a sample feeding suspension signal to the sample feeding mechanism 100 .
在一个实施例中，送样机构100包括样品送样带110以及送样驱动部件。送样驱动部件在附图1及附图2中均未示出。样品送样带110上设置有多个顺序排列的样品送样槽，样品送样槽设置在样品送样带110的正面，在附图1中所示的方向，样品送样槽位于样品送样带110的上表面。送样驱动部件连接于样品送样带110以用于驱动样品送样带110运动。送样驱动部件可以是驱动电机。进样时，通过样品送样带110可实现连续送样，可满足大批量样品的连续检测，在检测时，送样机构100驱动样品送样带110移动预设距离，该距离能够使得样品送样带110上的样品送样槽移动至点样机构200处，点样机构200向样品送样槽内加样，加样完毕后送样机构100驱动样品送样带110移动至位置检测机构300处，当位置检测机构300检测到样品送样槽中的样品到达质谱检测设备的检测区域时，位置检测机构300给送样机构100发送暂停送样信号，送样机构100停止驱动样品送样带110移动，样品在此处被质谱检测设备检测。In one embodiment, the sample feeding mechanism 100 includes a sample feeding belt 110 and a sample feeding driving component. The sample feeding drive components are not shown in FIG. 1 and FIG. 2 . The sample feeding belt 110 is provided with a plurality of sample feeding grooves arranged in sequence. The sample feeding grooves are arranged on the front side of the sample feeding belt 110. In the direction shown in FIG. 1, the sample feeding grooves are located in the sample feeding grooves. The upper surface of the belt 110 . The sample feeding driving part is connected to the sample feeding belt 110 for driving the sample feeding belt 110 to move. The sample feeding drive component may be a drive motor. During sample injection, continuous sample feeding can be achieved through the sample feeding belt 110, which can meet the continuous detection of large batches of samples. During the detection, the sample feeding mechanism 100 drives the sample feeding belt 110 to move a preset distance, which can make the sample feeding. The sample feeding slot on the sample belt 110 moves to the spotting mechanism 200, and the spotting mechanism 200 adds samples to the sample feeding slot. After the sample is added, the sample feeding mechanism 100 drives the sample feeding belt 110 to move to the position detection mechanism 300. When the position detection mechanism 300 detects that the sample in the sample feeding tank reaches the detection area of the mass spectrometry detection device, the position detection mechanism 300 sends a sample feeding suspension signal to the sample feeding mechanism 100, and the sample feeding mechanism 100 stops driving the sample feeding belt 110 moves, where the sample is detected by mass spectrometry detection equipment.
在一个实施例中，送样机构100还包括第一转动轮120以及第二转动轮130。第一转动轮120与第二转动轮130相对设置。第一转动轮120以及第二转动轮130通过样品送样带110连接，送样驱动部件连接于第一转动轮120和/或第二转动轮130以用于驱动第一转动轮120和第二转动轮130转动。第一转动轮120用于卷取样品送样带110未加样的部分，第二转动轮130用于卷取样品送样带110加样后且已质谱检测的部分。当样品送样带110未使用之前是呈卷状的，整卷的样品送样带110可以套设于第一转动轮120上，使用时将样品送样带110的头部牵伸至第二转动轮130上，送样驱动部件驱动第二转动轮130转动时，能够带动第一转动轮120上的样品送样带110释放。In one embodiment, the sample feeding mechanism 100 further includes a first rotating wheel 120 and a second rotating wheel 130 . The first rotating wheel 120 is disposed opposite to the second rotating wheel 130 . The first rotating wheel 120 and the second rotating wheel 130 are connected by the sample feeding belt 110, and the sample feeding driving component is connected to the first rotating wheel 120 and/or the second rotating wheel 130 for driving the first rotating wheel 120 and the second rotating wheel 130. The rotating wheel 130 rotates. The first rotating wheel 120 is used for winding up the unsampled part of the sample feeding belt 110 , and the second rotating wheel 130 is used for winding up the part of the sample feeding belt 110 that has been loaded and detected by mass spectrometry. When the sample feeding belt 110 is in a roll shape before it is not in use, the whole roll of the sample feeding belt 110 can be sleeved on the first rotating wheel 120, and the head of the sample feeding belt 110 is drawn to the second rotating wheel 120 when in use. On the rotating wheel 130, when the sample feeding driving component drives the second rotating wheel 130 to rotate, it can drive the sample feeding belt 110 on the first rotating wheel 120 to release.
在一个实施例中，送样机构100还包括压轮140。压轮140与第二转动轮130相对设置，压轮140活动设置，压轮140与第二转动轮130之间具有用于供样品送样带110通过的间隙，压轮140配合于第二转动轮130以辅助第二转动轮130卷取样品送样带110加样后且已质谱检测的部分。In one embodiment, the sample feeding mechanism 100 further includes a pressing wheel 140 . The pressing wheel 140 is arranged opposite to the second rotating wheel 130, the pressing wheel 140 is arranged movably, there is a gap between the pressing wheel 140 and the second rotating wheel 130 for the sample feeding belt 110 to pass through, and the pressing wheel 140 is matched with the second rotating wheel 130. The wheel 130 is used to assist the second rotating wheel 130 to wind up the portion of the sample feeding belt 110 that has been loaded and detected by mass spectrometry.
在一个实施例中，送样驱动部件连接于第二转动轮130。第一转动轮120作 为从动轮进行配合送样。In one embodiment, the sample feeding driving part is connected to the second rotating wheel 130 . The first rotating wheel 120 serves as a driven wheel for cooperative sample feeding.
在一个实施例中，连续式质谱进样装置10还包括张紧机构400。张紧机构400包括至少两个张紧限位柱410，张紧限位柱410设置在第一转动轮120与第二转动轮130之间，张紧限位柱410用于张紧样品送样带110。参见图1所示方向，在高度方向上，张紧限位柱410的位置比第一转动轮120以及第二转动轮130的位置均高出一点，保证两个张紧限位柱410能够张紧样品送样带110。In one embodiment, the continuous mass spectrometry sample introduction device 10 further includes a tensioning mechanism 400 . The tensioning mechanism 400 includes at least two tensioning limit posts 410 . The tensioning and limiting posts 410 are disposed between the first rotating wheel 120 and the second rotating wheel 130 , and the tensioning and limiting posts 410 are used for tensioning the sample feeding. Take 110. Referring to the direction shown in FIG. 1 , in the height direction, the position of the tension limit post 410 is a little higher than the positions of the first rotating wheel 120 and the position of the second rotating wheel 130 to ensure that the two tension limit posts 410 can be stretched Tighten the sample feeding belt 110.
在一个实施例中，样品送样带110上的样品送样槽沿着样品送样带110的长度方向顺序分布。样品送样带110上相邻的样品送样槽之间具有间隔且相邻的样品送样槽之间的间距相等。由于相邻的样品送样槽之间的间距均相等，可保证样品进样位置的一致性，减小了人为误差。In one embodiment, the sample feeding slots on the sample feeding belt 110 are sequentially distributed along the length direction of the sample feeding belt 110 . The adjacent sample feeding grooves on the sample feeding belt 110 are spaced apart, and the spacings between adjacent sample feeding grooves are equal. Since the distances between adjacent sample feeding slots are equal, the consistency of sample injection positions can be ensured, and human errors can be reduced.
在一个实施例中，点样机构200与位置检测机构300之间具有间隔。本发明的连续式质谱进样装置10在相邻的样品送样槽之间设置了间隔，且在点样机构200与位置检测机构300之间也设置了间隔，可有效减小或消除样品间的交叉污染。In one embodiment, there is a gap between the spotting mechanism 200 and the position detecting mechanism 300 . In the continuous mass spectrometry sampling device 10 of the present invention, an interval is set between adjacent sample feeding slots, and an interval is also set between the spotting mechanism 200 and the position detection mechanism 300, which can effectively reduce or eliminate the gap between samples of cross-contamination.
在一个实施例中，点样机构200与位置检测机构300之间的间距等于相邻的样品送样槽之间的间距。In one embodiment, the distance between the spotting mechanism 200 and the position detection mechanism 300 is equal to the distance between adjacent sample feeding slots.
在一个实施例中，连续式质谱进样装置10还包括支架，其中，点样机构200、位置检测机构300设置在支架上。另外，第一转动轮120、第二转动轮130以及张紧限位柱410均设置在支架上，此时，整个的连续式质谱进样装置10集成于一个支架上，便于与质谱检测设备之间的安装。支架在附图1及附图2中均未示出。In one embodiment, the continuous mass spectrometry sample introduction device 10 further includes a support, wherein the spotting mechanism 200 and the position detection mechanism 300 are arranged on the support. In addition, the first rotating wheel 120, the second rotating wheel 130 and the tensioning limit post 410 are all arranged on the bracket. At this time, the entire continuous mass spectrometer sampling device 10 is integrated on one bracket, which is convenient for the connection with the mass spectrometry detection equipment. installation between. The brackets are not shown in both Figures 1 and 2 .
本发明一实施例该提供了一种质谱检测设备。An embodiment of the present invention provides a mass spectrometry detection device.
一种质谱检测设备，包括上述的连续式质谱进样装置10。A mass spectrometry detection device includes the above-mentioned continuous mass spectrometry sampling device 10 .
实施例1Example 1
本实施例提供了一种连续式质谱进样装置10。This embodiment provides a continuous mass spectrometry sampling device 10 .
参见图1所示，一种连续式质谱进样装置10，包括送样机构100、点样机构200、张紧机构400以及位置检测机构300。Referring to FIG. 1 , a continuous mass spectrometry sample introduction device 10 includes a sample feeding mechanism 100 , a sample spotting mechanism 200 , a tensioning mechanism 400 and a position detecting mechanism 300 .
送样机构100上顺序设置有多个样品送样槽。样品送样带110上的样品送样槽沿着样品送样带110的长度方向顺序分布。样品送样带110上相邻的样品送样槽之间具有间隔且相邻的样品送样槽之间的间距相等。The sample feeding mechanism 100 is sequentially provided with a plurality of sample feeding grooves. The sample feeding slots on the sample feeding belt 110 are sequentially distributed along the length direction of the sample feeding belt 110 . The adjacent sample feeding grooves on the sample feeding belt 110 are spaced apart, and the spacings between adjacent sample feeding grooves are equal.
送样机构100具有加样端以及回收端。送样机构100能够将样品送样槽输送至质谱检测设备的检测区域。The sample feeding mechanism 100 has a sample adding end and a recovery end. The sample feeding mechanism 100 can transport the sample feeding tank to the detection area of the mass spectrometry detection device.
点样机构200设置在加样端的上方以用于向各个样品送样槽内加样。The sample spotting mechanism 200 is arranged above the sample adding end for adding samples to each sample feeding slot.
位置检测机构300设置在预定位置并用于检测样品送样槽中的样品是否到达质谱检测设备的检测区域并给送样机构100发送暂停送样信号。当位置检测机构300检测到样品送样槽中的样品到达质谱检测设备的检测区域时，位置检测机构300给送样机构100发送暂停送样信号，送样机构100停止驱动样品送样带110移动，样品在此处被质谱检测设备检测。The position detection mechanism 300 is arranged at a predetermined position and is used to detect whether the sample in the sample feeding tank reaches the detection area of the mass spectrometry detection device and send a sample feeding suspension signal to the sample feeding mechanism 100 . When the position detection mechanism 300 detects that the sample in the sample feeding slot reaches the detection area of the mass spectrometry detection device, the position detection mechanism 300 sends a sample feeding suspension signal to the sample feeding mechanism 100, and the sample feeding mechanism 100 stops driving the sample feeding belt 110 to move. , where the sample is detected by mass spectrometry detection equipment.
点样机构200与位置检测机构300之间具有间隔。点样机构200与位置检测机构300之间具有间距等于相邻的样品送样槽之间的间距。There is a gap between the spotting mechanism 200 and the position detecting mechanism 300 . The spacing between the spotting mechanism 200 and the position detecting mechanism 300 is equal to the spacing between adjacent sample feeding slots.
送样机构100包括样品送样带110以及送样驱动部件。样品送样带110上设置有多个顺序排列的样品送样槽，送样驱动部件连接于样品送样带110以用于驱动样品送样带110运动。送样驱动部件为驱动电机。The sample feeding mechanism 100 includes a sample feeding belt 110 and a sample feeding driving part. The sample feeding belt 110 is provided with a plurality of sample feeding grooves arranged in sequence, and the sample feeding driving component is connected to the sample feeding belt 110 for driving the sample feeding belt 110 to move. The sample feeding drive part is a drive motor.
送样机构100还包括第一转动轮120以及第二转动轮130。第一转动轮120与第二转动轮130相对设置。第一转动轮120以及第二转动轮130通过样品送样带110连接，送样驱动部件连接于第二转动轮130以用于驱动第一转动轮120和第二转动轮130转动。第一转动轮120用于卷取样品送样带110未加样的部分，第二转动轮130用于卷取样品送样带110加样后且已质谱检测的部分。The sample feeding mechanism 100 further includes a first rotating wheel 120 and a second rotating wheel 130 . The first rotating wheel 120 is disposed opposite to the second rotating wheel 130 . The first rotating wheel 120 and the second rotating wheel 130 are connected by the sample feeding belt 110 , and the sample feeding driving component is connected to the second rotating wheel 130 for driving the first rotating wheel 120 and the second rotating wheel 130 to rotate. The first rotating wheel 120 is used for winding up the unsampled part of the sample feeding belt 110 , and the second rotating wheel 130 is used for winding up the part of the sample feeding belt 110 that has been loaded and detected by mass spectrometry.
送样机构100还包括压轮140。压轮140与第二转动轮130相对设置，压轮140活动设置，压轮140与第二转动轮130之间具有用于供样品送样带110通过的间隙，压轮140配合于第二转动轮130以辅助第二转动轮130卷取样品送样带110加样后且已质谱检测的部分。The sample feeding mechanism 100 further includes a pressing wheel 140 . The pressing wheel 140 is arranged opposite to the second rotating wheel 130, the pressing wheel 140 is arranged movably, there is a gap between the pressing wheel 140 and the second rotating wheel 130 for the sample feeding belt 110 to pass through, and the pressing wheel 140 is matched with the second rotating wheel 130. The wheel 130 is used to assist the second rotating wheel 130 to wind up the portion of the sample feeding belt 110 that has been loaded and detected by mass spectrometry.
张紧机构400包括两个张紧限位柱410，两个张紧限位柱410设置在第一转动轮120与第二转动轮130之间，且其中一个张紧限位柱410靠近于第一转动轮120，另一个张紧限位柱410靠近于第二转动轮130，张紧限位柱410用于支 撑并张紧样品送样带110，以便于点样机构200加样以及位置检测机构300的检测。The tensioning mechanism 400 includes two tensioning limiting posts 410, the two tensioning limiting posts 410 are disposed between the first rotating wheel 120 and the second rotating wheel 130, and one of the tensioning limiting posts 410 is close to the first rotating wheel 120 and the second rotating wheel 130. One rotating wheel 120, another tensioning limit post 410 is close to the second rotating wheel 130, and the tensioning limit post 410 is used to support and tension the sample feeding belt 110, so as to facilitate sample loading and position detection of the spotting mechanism 200 Detection of the mechanism 300 .
实施例2Example 2
本实施例提供了一种连续式质谱进样装置10。This embodiment provides a continuous mass spectrometry sampling device 10 .
参见图2所示，一种连续式质谱进样装置10，包括送样机构100、点样机构200以及位置检测机构300。Referring to FIG. 2 , a continuous mass spectrometry sample introduction device 10 includes a sample feeding mechanism 100 , a sample spotting mechanism 200 and a position detection mechanism 300 .
送样机构100上顺序设置有多个样品送样槽。样品送样带110上的样品送样槽沿着样品送样带110的长度方向顺序分布。样品送样带110上相邻的样品送样槽之间具有间隔且相邻的样品送样槽之间的间距相等。The sample feeding mechanism 100 is sequentially provided with a plurality of sample feeding grooves. The sample feeding slots on the sample feeding belt 110 are sequentially distributed along the length direction of the sample feeding belt 110 . The adjacent sample feeding grooves on the sample feeding belt 110 are spaced apart, and the spacings between adjacent sample feeding grooves are equal.
送样机构100具有加样端以及回收端。送样机构100能够将样品送样槽输送至质谱检测设备的检测区域。The sample feeding mechanism 100 has a sample adding end and a recovery end. The sample feeding mechanism 100 can transport the sample feeding tank to the detection area of the mass spectrometry detection device.
点样机构200设置在加样端的上方以用于向各个样品送样槽内加样。The sample spotting mechanism 200 is arranged above the sample adding end for adding samples to each sample feeding slot.
位置检测机构300设置在预定位置并用于检测样品送样槽中的样品是否到达质谱检测设备的检测区域并给送样机构100发送暂停送样信号。当位置检测机构300检测到样品送样槽中的样品到达质谱检测设备的检测区域时，位置检测机构300给送样机构100发送暂停送样信号，送样机构100停止驱动样品送样带110移动，样品在此处被质谱检测设备检测。The position detection mechanism 300 is arranged at a predetermined position and is used to detect whether the sample in the sample feeding tank reaches the detection area of the mass spectrometry detection device and send a sample feeding suspension signal to the sample feeding mechanism 100 . When the position detection mechanism 300 detects that the sample in the sample feeding slot reaches the detection area of the mass spectrometry detection device, the position detection mechanism 300 sends a sample feeding suspension signal to the sample feeding mechanism 100, and the sample feeding mechanism 100 stops driving the sample feeding belt 110 to move. , where the sample is detected by mass spectrometry detection equipment.
点样机构200与位置检测机构300之间具有间隔。点样机构200与位置检测机构300之间具有间距等于相邻的样品送样槽之间的间距。There is a gap between the spotting mechanism 200 and the position detecting mechanism 300 . The spacing between the spotting mechanism 200 and the position detecting mechanism 300 is equal to the spacing between adjacent sample feeding slots.
送样机构100包括样品送样带110以及送样驱动部件。样品送样带110上设置有多个顺序排列的样品送样槽，送样驱动部件连接于样品送样带110以用于驱动样品送样带110运动。送样驱动部件为驱动电机。The sample feeding mechanism 100 includes a sample feeding belt 110 and a sample feeding driving part. The sample feeding belt 110 is provided with a plurality of sample feeding grooves arranged in sequence, and the sample feeding driving component is connected to the sample feeding belt 110 for driving the sample feeding belt 110 to move. The sample feeding drive part is a drive motor.
参见图2所示，送样机构100还包括第一转动轮120、第二转动轮130以及压轮140。第一转动轮120与第二转动轮130相对设置。第一转动轮120以及第二转动轮130通过样品送样带110连接，送样驱动部件连接于第二转动轮130以用于驱动第一转动轮120和第二转动轮130转动。第一转动轮120用于卷取样品送样带110未加样的部分，第二转动轮130用于卷取样品送样带110加样 后且已质谱检测的部分。Referring to FIG. 2 , the sample feeding mechanism 100 further includes a first rotating wheel 120 , a second rotating wheel 130 and a pressing wheel 140 . The first rotating wheel 120 is disposed opposite to the second rotating wheel 130 . The first rotating wheel 120 and the second rotating wheel 130 are connected by the sample feeding belt 110 , and the sample feeding driving component is connected to the second rotating wheel 130 for driving the first rotating wheel 120 and the second rotating wheel 130 to rotate. The first rotating wheel 120 is used for winding up the unsampled portion of the sample feeding belt 110, and the second rotating wheel 130 is used for winding up the portion of the sample feeding belt 110 that has been loaded and detected by mass spectrometry.
参见图2所示，压轮140与第二转动轮130相对设置，压轮140活动设置，压轮140与第二转动轮130之间具有用于供样品送样带110通过的间隙，压轮140配合于第二转动轮130以辅助第二转动轮130卷取样品送样带110加样后且已质谱检测的部分，压轮140用于压住第二转动轮130上的样品送样带110。Referring to FIG. 2 , the pressing wheel 140 is arranged opposite to the second rotating wheel 130 , the pressing wheel 140 is movably arranged, and there is a gap between the pressing wheel 140 and the second rotating wheel 130 for the sample feeding belt 110 to pass through. The 140 is matched with the second rotating wheel 130 to assist the second rotating wheel 130 to take up the part of the sample feeding belt 110 after the sample is loaded and has been detected by mass spectrometry. The pressing wheel 140 is used to press the sample feeding belt on the second rotating wheel 130. 110.
张紧机构400包括两个张紧限位柱410，两个张紧限位柱410设置在第一转动轮120与第二转动轮130之间，且其中一个张紧限位柱410靠近于第一转动轮120，另一个张紧限位柱410靠近于第二转动轮130，张紧限位柱410用于支撑并张紧样品送样带110，以便于点样机构200加样以及位置检测机构300的检测。The tensioning mechanism 400 includes two tensioning limiting posts 410, the two tensioning limiting posts 410 are disposed between the first rotating wheel 120 and the second rotating wheel 130, and one of the tensioning limiting posts 410 is close to the first rotating wheel 120 and the second rotating wheel 130. One rotating wheel 120, another tensioning limit post 410 is close to the second rotating wheel 130, and the tensioning limit post 410 is used to support and tension the sample feeding belt 110, so as to facilitate sample loading and position detection of the spotting mechanism 200 Detection of the mechanism 300 .
综上，本发明的连续式质谱进样装置10具有如下有益效果：To sum up, the continuous mass spectrometry sample introduction device 10 of the present invention has the following beneficial effects:
(1)、本发明的连续式质谱进样装置10用于质谱进样时，无需频繁更换载样台，通过样品送样带110可实现连续送样，可满足大批量样品的连续检测，在检测时，送样机构100驱动样品送样带110移动预设距离，该距离能够使得样品送样带110上的样品送样槽移动至点样机构200处，点样机构200向样品送样槽内加样，加样完毕后送样机构100驱动样品送样带110移动至位置检测机构300处，当位置检测机构300检测到样品送样槽中的样品到达质谱检测设备的检测区域时，位置检测机构300给送样机构100发送暂停送样信号，送样机构100停止驱动样品送样带110移动，样品在此处被质谱检测设备检测。(1) When the continuous mass spectrometry sampling device 10 of the present invention is used for mass spectrometry sampling, there is no need to frequently replace the sample stage, and the sample feeding belt 110 can realize continuous sample feeding, which can meet the continuous detection of large batches of samples. During detection, the sample feeding mechanism 100 drives the sample feeding belt 110 to move a preset distance, which can make the sample feeding slot on the sample feeding belt 110 move to the spotting mechanism 200, and the spotting mechanism 200 moves to the sample feeding slot. Internal sample addition, after the sample addition is completed, the sample feeding mechanism 100 drives the sample feeding belt 110 to move to the position detection mechanism 300. When the position detection mechanism 300 detects that the sample in the sample feeding slot reaches the detection area of the mass spectrometry detection device, the position The detection mechanism 300 sends a sample feeding suspension signal to the sample feeding mechanism 100, and the sample feeding mechanism 100 stops driving the sample feeding belt 110 to move, where the sample is detected by the mass spectrometry detection device.
(2)、本发明的连续式质谱进样装置10中，由于相邻的样品送样槽之间的间距均相等，可保证样品进样位置的一致性，减小了人为误差。(2) In the continuous mass spectrometry sampling device 10 of the present invention, since the distances between adjacent sample feeding slots are equal, the consistency of the sampling positions of the samples can be ensured, and the human error can be reduced.
(3)本发明的连续式质谱进样装置10实现了自动加样、自动进样的动作，自动化程度高，减少了人工参与，提高了检测效率。(3) The continuous mass spectrometry sample introduction device 10 of the present invention realizes the actions of automatic sample addition and automatic sample introduction, and has a high degree of automation, reduces manual participation, and improves detection efficiency.
(4)、本发明的连续式质谱进样装置10在相邻的样品送样槽之间设置了间隔，且在点样机构200与位置检测机构300之间也设置了间隔，可有效减小或消除样品间的交叉污染。(4) In the continuous mass spectrometry sample introduction device 10 of the present invention, an interval is set between adjacent sample feeding slots, and an interval is also set between the spotting mechanism 200 and the position detection mechanism 300, which can effectively reduce the Or eliminate cross-contamination between samples.
以上所述实施例的各技术特征可以进行任意的组合，为使描述简洁，未对 上述实施例中的各个技术特征所有可能的组合都进行描述，然而，只要这些技术特征的组合不存在矛盾，都应当认为是本说明书记载的范围。The technical features of the above-described embodiments can be combined arbitrarily. For the sake of brevity, all possible combinations of the technical features in the above-described embodiments are not described. However, as long as there is no contradiction between the combinations of these technical features, All should be regarded as the scope described in this specification.
以上所述实施例仅表达了本发明的几种实施方式，其描述较为具体和详细，但并不能因此而理解为对本发明专利范围的限制。应当指出的是，对于本领域的普通技术人员来说，在不脱离本发明构思的前提下，还可以做出若干变形和改进，这些都属于本发明的保护范围。因此，本发明专利的保护范围应以所附权利要求为准。The above-mentioned embodiments only represent several embodiments of the present invention, and the descriptions thereof are specific and detailed, but should not be construed as a limitation on the scope of the patent of the present invention. It should be pointed out that for those of ordinary skill in the art, without departing from the concept of the present invention, several modifications and improvements can also be made, which all belong to the protection scope of the present invention. Therefore, the protection scope of the patent of the present invention should be subject to the appended claims.

Claims (10)

  1. 一种连续式质谱进样装置，其特征在于，包括送样机构、点样机构以及位置检测机构；所述送样机构上顺序设置有多个样品送样槽，所述送样机构具有加样端以及回收端，所述送样机构用于将所述样品送样槽输送至质谱检测设备的检测区域，所述点样机构设置在所述加样端的上方以用于向各个所述样品送样槽内加样，所述位置检测机构设置在预定位置以用于检测所述样品送样槽中的样品是否到达质谱检测设备的检测区域并给送样机构发送暂停送样信号。A continuous mass spectrometry sample introduction device is characterized in that it includes a sample feeding mechanism, a sample spotting mechanism and a position detection mechanism; a plurality of sample feeding slots are sequentially arranged on the sample feeding mechanism, and the sample feeding mechanism has a sample feeding mechanism. and a recovery end, the sample feeding mechanism is used to transport the sample feeding slot to the detection area of the mass spectrometry detection device, and the spotting mechanism is arranged above the sample feeding end for feeding each of the samples The sample is loaded in the sample tank, and the position detection mechanism is arranged at a predetermined position to detect whether the sample in the sample sample feeding tank reaches the detection area of the mass spectrometry detection device and send a sample feeding suspension signal to the sample feeding mechanism.
  2. 根据权利要求1所述的连续式质谱进样装置，其特征在于，所述送样机构包括样品送样带以及送样驱动部件，所述样品送样带上设置有多个顺序排列的所述样品送样槽，所述送样驱动部件连接于所述样品送样带以用于驱动所述样品送样带运动。The continuous mass spectrometry sample introduction device according to claim 1, wherein the sample feeding mechanism comprises a sample feeding belt and a sample feeding driving part, and a plurality of the sample feeding belts arranged in sequence are arranged on the sample feeding belt. A sample feeding slot, the sample feeding driving component is connected to the sample feeding belt for driving the sample feeding belt to move.
  3. 根据权利要求2所述的连续式质谱进样装置，其特征在于，所述送样机构还包括第一转动轮以及第二转动轮，所述第一转动轮与所述第二转动轮相对设置，所述第一转动轮以及所述第二转动轮通过所述样品送样带连接，所述送样驱动部件连接于所述第一转动轮和/或所述第二转动轮以用于驱动所述第一转动轮和所述第二转动轮转动，所述第一转动轮用于放置所述样品送样带未加样的部分，所述第二转动轮用于卷取所述样品送样带加样后且已质谱检测的部分。The continuous mass spectrometry sample introduction device according to claim 2, wherein the sample feeding mechanism further comprises a first rotating wheel and a second rotating wheel, and the first rotating wheel and the second rotating wheel are arranged opposite to each other. , the first rotating wheel and the second rotating wheel are connected through the sample feeding belt, and the sample feeding driving part is connected to the first rotating wheel and/or the second rotating wheel for driving The first rotating wheel and the second rotating wheel rotate, the first rotating wheel is used for placing the unloaded part of the sample feeding belt, and the second rotating wheel is used for winding the sample feeding belt. The portion of the sample strip that has been loaded and detected by mass spectrometry.
  4. 根据权利要求3所述的连续式质谱进样装置，其特征在于，所述送样机构还包括压轮，所述压轮与所述第二转动轮相对设置，所述压轮活动设置，所述压轮与所述第二转动轮之间具有用于供样品送样带通过的间隙，所述压轮配合于所述第二转动轮以辅助所述第二转动轮卷取所述样品送样带加样后且已质谱检测的部分。The continuous mass spectrometry sample introduction device according to claim 3, wherein the sample feeding mechanism further comprises a pressing wheel, the pressing wheel is arranged opposite to the second rotating wheel, and the pressing wheel is movably arranged so that the There is a gap for the sample feeding belt to pass between the pressing wheel and the second rotating wheel, and the pressing wheel is matched with the second rotating wheel to assist the second rotating wheel to take up the sample and send the sample. The portion of the sample strip that has been loaded and detected by mass spectrometry.
  5. 根据权利要求3所述的连续式质谱进样装置，其特征在于，所述送样驱动部件连接于所述第二转动轮。The continuous mass spectrometry sample introduction device according to claim 3, wherein the sample feeding driving part is connected to the second rotating wheel.
  6. 根据权利要求3所述的连续式质谱进样装置，其特征在于，所述连续式质谱进样装置还包括张紧机构，所述张紧机构包括至少两个张紧限位柱，所述张紧限位柱设置在第一转动轮与所述第二转动轮之间，所述张紧限位柱用于张 紧所述样品送样带。The continuous mass spectrometry sampling device according to claim 3, wherein the continuous mass spectrometry sampling device further comprises a tensioning mechanism, the tensioning mechanism comprises at least two tensioning limit posts, the tensioning A tightening and limiting column is arranged between the first rotating wheel and the second rotating wheel, and the tightening and limiting column is used for tightening the sample feeding belt.
  7. 根据权利要求1-6任意一项所述的连续式质谱进样装置，其特征在于，所述样品送样带上的所述样品送样槽沿着所述样品送样带的长度方向顺序分布，所述样品送样带上相邻的所述样品送样槽之间具有间隔且相邻的所述样品送样槽之间的间距相等。The continuous mass spectrometry sampling device according to any one of claims 1-6, wherein the sample feeding grooves on the sample feeding belt are sequentially distributed along the length direction of the sample feeding belt , the adjacent sample feeding grooves on the sample feeding belt are spaced apart, and the spacings between the adjacent sample feeding grooves are equal.
  8. 根据权利要求7所述的连续式质谱进样装置，其特征在于，所述点样机构与所述位置检测机构之间具有间隔。The continuous mass spectrometry sample introduction device according to claim 7, wherein there is a gap between the spotting mechanism and the position detection mechanism.
  9. 根据权利要求8所述的连续式质谱进样装置，其特征在于，所述点样机构与所述位置检测机构之间的间距等于相邻的样品送样槽之间的间距。The continuous mass spectrometry sample introduction device according to claim 8, wherein the distance between the spotting mechanism and the position detection mechanism is equal to the distance between adjacent sample feeding grooves.
  10. 一种质谱检测设备，其特征在于，包括权利要求1-9任意一项所述的连续式质谱进样装置。A mass spectrometry detection device, characterized in that it comprises the continuous mass spectrometry sampling device according to any one of claims 1-9.
PCT/CN2020/142334 2020-12-12 2020-12-31 Continuous mass spectrum sample injection device and mass spectrum detection apparatus WO2022121056A1 (en)

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