WO2022089400A1 - 靶向降解Btk的化合物及其抗肿瘤用途 - Google Patents
靶向降解Btk的化合物及其抗肿瘤用途 Download PDFInfo
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- WO2022089400A1 WO2022089400A1 PCT/CN2021/126315 CN2021126315W WO2022089400A1 WO 2022089400 A1 WO2022089400 A1 WO 2022089400A1 CN 2021126315 W CN2021126315 W CN 2021126315W WO 2022089400 A1 WO2022089400 A1 WO 2022089400A1
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- ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 description 1
- UAEJRRZPRZCUBE-UHFFFAOYSA-N trimethoxyalumane Chemical compound [Al+3].[O-]C.[O-]C.[O-]C UAEJRRZPRZCUBE-UHFFFAOYSA-N 0.000 description 1
- 238000004704 ultra performance liquid chromatography Methods 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Definitions
- the invention belongs to the field of medicine, and particularly relates to a compound targeting Btk degraded and its anti-tumor use.
- Btk (Bruton's tyrosine kinase), Bruton's tyrosine kinase, is a member of the non-receptor tyrosine kinase Tec family and is an essential gene for cell differentiation and proliferation. ) and in plasmacytoma. Btk is a key component of the B-cell receptor (BCR) signaling pathway and is a good target for targeted therapy of diseases such as B-cell lymphoma.
- BCR B-cell receptor
- Btk is a key regulator of B cell development, activation, signaling, and survival, and is involved in the regulation of angiogenesis, cell proliferation and apoptosis, and cell motility.
- Btk is also involved in many other hematopoietic cell signaling pathways, for example, in the signaling pathway mediated by Toll-like receptors and cytokine receptors in macrophages, and in the signaling of IgE receptors in mast cells.
- non-Hodgkin's lymphoma NHL
- CLL chronic lymphocytic leukemia
- B-cell lymphoma B-cell lymphoma
- autoimmune diseases rheumatoid arthritis, psoriasis, etc.
- the object of the present invention is to provide a compound for inhibiting and degrading Btk with good permeability and good permeability, and its application.
- composition in a second aspect of the present invention, contains the compound described in the first aspect, its isomer, prodrug, pharmaceutically acceptable salt, and pharmaceutically acceptable salt acceptable carrier.
- the pharmaceutical composition further comprises another one or more antitumor agents.
- the pharmaceutical composition is used to inhibit the activity of Bruton's tyrosine kinase (Btk) or reduce the level of Bruton's tyrosine protein kinase (Btk).
- the pharmaceutical composition is used to treat diseases related to Bruton's tyrosine kinase (Btk) activity or expression.
- Btk Bruton's tyrosine kinase
- the third aspect of the present invention provides a use of the compound as described in the first aspect of the present invention for:
- the diseases include tumors, autoimmune diseases; preferably, the tumors include non-Hodgkin's lymphoma (NHL), chronic lymphocytic leukemia (CLL), B-cell lymphoma, etc.;
- the autoimmune diseases include rheumatoid arthritis, psoriasis and the like.
- the terms “comprising”, “comprising” or “including” mean that the various ingredients can be used together in the mixture or composition of the present invention.
- the terms “consisting essentially of” and “consisting of” are encompassed by the term “comprising”.
- the term "pharmaceutically acceptable” ingredients refers to substances that are suitable for use in humans and/or animals without excessive adverse side effects (such as toxicity, irritation and allergy), ie, have a reasonable benefit/risk ratio.
- the term "effective amount" refers to an amount of a therapeutic agent that treats, alleviates or prevents a target disease or condition, or an amount that exhibits a detectable therapeutic or prophylactic effect.
- the precise effective amount for a subject depends on the size and health of the subject, the nature and extent of the disorder, and the therapeutic agent and/or combination of therapeutic agents selected for administration. Therefore, it is useless to prespecify the exact effective amount. However, for a given situation, routine experimentation can be used to determine the effective amount, as is the judgment of the clinician.
- each chiral carbon atom can optionally be in the R configuration or the S configuration, or a mixture of the R and S configurations.
- the term "compounds of the present invention” refers to each of the compounds set forth herein.
- the term also includes the various crystalline forms, pharmaceutically acceptable salts, hydrates or solvates of each compound.
- the term "pharmaceutically acceptable salt” refers to a salt of a compound of the present invention with an acid or base suitable for use as a medicament.
- Pharmaceutically acceptable salts include inorganic and organic salts.
- a preferred class of salts are the salts of the compounds of the present invention with acids.
- Acids suitable for forming salts include, but are not limited to, inorganic acids such as hydrochloric, hydrobromic, hydrofluoric, sulfuric, nitric, phosphoric, formic, acetic, propionic, oxalic, malonic, succinic, fumaric, Maleic acid, lactic acid, malic acid, tartaric acid, citric acid, picric acid, methanesulfonic acid, benzenemethanesulfonic acid, benzenesulfonic acid and other organic acids; and acidic amino acids such as aspartic acid and glutamic acid.
- inorganic acids such as hydrochloric, hydrobromic, hydrofluoric, sulfuric, nitric, phosphoric, formic, acetic, propionic, oxalic, malonic, succinic, fumaric, Maleic acid, lactic acid, malic acid, tartaric acid, citric acid, picric acid, methanesulfonic acid, benzene
- the present invention relates to the following compounds or their pharmaceutically acceptable salts or their deuterated compounds:
- the present invention has carried out a lot of optimization and screening on the structure of compounds that inhibit and degrade Btk.
- the results show that the above compounds, compared with other compounds, have excellent permeability, low efflux ratio Good druggability; and showed significant inhibitory effect on ibrutinib-resistant tumor cells, with stronger anti-tumor activity; and achieved unexpected technical effects.
- the compounds of the present invention may form pharmaceutically acceptable salts with inorganic acids, organic acids or bases.
- Described inorganic acid includes but not limited to hydrochloric acid, hydrobromic acid, nitric acid, perchloric acid, sulfuric acid or phosphoric acid etc.
- Described organic acid includes but not limited to methanesulfonic acid, trifluoromethanesulfonic acid, ethanesulfonic acid, benzene Sulfonic acid, p-toluenesulfonic acid, fumaric acid, oxalic acid, acetic acid, maleic acid, ascorbic acid, lactic acid, tartaric acid, malonic acid, glycolic acid, succinic acid and propionic acid, etc.
- the bases include but are not limited to inorganic acids salts and amines.
- pharmaceutically acceptable salts refers to those salts which, according to medical judgment, are suitable for use in contact with human and mammalian tissues without undue toxicity, irritation, allergic response, and the like. Pharmaceutically acceptable salts are well known in the art.
- the present invention also encompasses pharmaceutical compositions containing prodrugs of the respective compounds.
- Prodrugs include compounds in which the precursor molecule is covalently bound to the free carboxyl group of the compounds of the present invention through a carbonate bond, carbamate bond, amide bond, alkyl ester bond, phosphate bond, phosphoramidate bond, on hydroxyl, amino or amine groups.
- the compounds of the present invention can be used for one or more of the following purposes:
- the diseases include tumors, autoimmune diseases; preferably, the tumors include non-Hodgkin's lymphoma (NHL), chronic lymphocytic leukemia (CLL), B-cell lymphoma, etc.;
- the autoimmune diseases include rheumatoid arthritis, psoriasis and the like.
- the compounds of the present invention can be used to prepare a pharmaceutical composition comprising: (i) an effective amount of a compound of the present invention, or a pharmaceutically acceptable salt thereof; and (ii) a pharmaceutically acceptable carrier .
- the effective amount refers to a therapeutically effective amount or an inhibitory effective amount.
- the compounds of the present invention can also be used in methods of inhibiting or degrading Bruton's tyrosine kinase (Btk), either non-therapeutic or therapeutic in vitro.
- Btk Bruton's tyrosine kinase
- the inhibitory effective amount of the compound of the present invention or a pharmaceutically acceptable salt thereof when administered to the inhibited object, is 0.001-500 nmol/L, preferably 0.01-200 nmol/L L.
- the present invention also provides a method for treating a disease associated with Bruton's tyrosine kinase (Btk) activity or expression level, the method comprising: administering to a subject a therapeutically effective amount of the compound of the present invention, Or the pharmaceutical composition containing the compound of the present invention as an active ingredient.
- Btk Bruton's tyrosine kinase
- compositions and methods of administration are provided.
- the compounds of the present invention have excellent inhibitory activity against Bruton's tyrosine kinase (Btk), the compounds of the present invention and various crystalline forms, pharmaceutically acceptable inorganic or organic salts, hydrates or solvates thereof , and the pharmaceutical composition containing the compound of the present invention as the main active ingredient can be used for the treatment, prevention and alleviation of diseases related to the activity or expression of Btk.
- the compounds of the present invention can be used to treat diseases including tumors and the like.
- the pharmaceutical composition of the present invention comprises the compound of the present invention or a pharmacologically acceptable salt thereof and a pharmacologically acceptable excipient or carrier within a safe and effective amount.
- the "safe and effective amount” refers to: the amount of the compound is sufficient to significantly improve the condition without causing serious side effects.
- the pharmaceutical composition contains 1-2000 mg of the compound of the present invention per dose, more preferably 5-500 mg of the compound of the present invention per dose.
- the "one dose” is a capsule or tablet.
- “Pharmaceutically acceptable carrier” refers to one or more compatible solid or liquid filler or gel substances which are suitable for human use and which must be of sufficient purity and sufficiently low toxicity. "Compatibility” as used herein means that the components of the composition can be admixed with the compounds of the present invention and with each other without significantly reducing the efficacy of the compounds.
- Examples of pharmaceutically acceptable carrier moieties include cellulose and its derivatives (such as sodium carboxymethyl cellulose, sodium ethyl cellulose, cellulose acetate, etc.), gelatin, talc, solid lubricants (such as stearic acid) , magnesium stearate), calcium sulfate, vegetable oils (such as soybean oil, sesame oil, peanut oil, olive oil, etc.), polyols (such as propylene glycol, glycerol, mannitol, sorbitol, etc.), emulsifiers (such as ), wetting agents (such as sodium lauryl sulfate), colorants, flavors, stabilizers, antioxidants, preservatives, pyrogen-free water, etc.
- cellulose and its derivatives such as sodium carboxymethyl cellulose, sodium ethyl cellulose, cellulose acetate, etc.
- gelatin such as sodium carboxymethyl cellulose, sodium ethyl cellulose, cellulose acetate, etc.
- the mode of administration of the compounds or pharmaceutical compositions of the present invention is not particularly limited, and representative modes of administration include (but are not limited to): oral, intratumoral, rectal, parenteral (intravenous, intramuscular or subcutaneous), and topical administration .
- Solid dosage forms for oral administration include capsules, tablets, pills, powders and granules.
- the active compound is mixed with at least one conventional inert excipient (or carrier), such as sodium citrate or dicalcium phosphate, or with (a) fillers or solubilizers, for example, starch , lactose, sucrose, glucose, mannitol and silicic acid; (b) binders such as hydroxymethylcellulose, alginate, gelatin, polyvinylpyrrolidone, sucrose and acacia; (c) humectants such as , glycerol; (d) disintegrants, such as agar, calcium carbonate, potato or tapioca starch, alginic acid, certain complex silicates, and sodium carbonate; (e) slow solvents, such as paraffin; (f) absorption Accelerators, eg, quaternary amine compounds; (g) wetting agents, eg, cetyl alcohol and g
- Solid dosage forms such as tablets, dragees, capsules, pills and granules can be prepared using coatings and shell materials, such as enteric coatings and other materials well known in the art. They may contain opacifying agents, and the release of the active compound or compounds in such compositions may be in a certain part of the digestive tract in a delayed manner. Examples of embedding components that can be employed are polymeric substances and waxes. If desired, the active compound may also be in microencapsulated form with one or more of the above-mentioned excipients.
- Liquid dosage forms for oral administration include pharmaceutically acceptable emulsions, solutions, suspensions, syrups or tinctures.
- liquid dosage forms may contain inert diluents conventionally employed in the art, such as water or other solvents, solubilizers and emulsifiers, for example, ethanol, isopropanol, ethyl carbonate, ethyl acetate, propylene glycol, 1 , 3-butanediol, dimethylformamide and oils, especially cottonseed oil, peanut oil, corn germ oil, olive oil, castor oil and sesame oil or mixtures of these substances, and the like.
- inert diluents conventionally employed in the art, such as water or other solvents, solubilizers and emulsifiers, for example, ethanol, isopropanol, ethyl carbonate, ethyl acetate, propylene glycol, 1 , 3-butanediol, dimethylform
- compositions can also contain adjuvants such as wetting agents, emulsifying and suspending agents, sweetening, flavoring and perfuming agents.
- adjuvants such as wetting agents, emulsifying and suspending agents, sweetening, flavoring and perfuming agents.
- Suspensions in addition to the active compounds, may contain suspending agents such as ethoxylated isostearyl alcohols, polyoxyethylene sorbitol and sorbitan esters, microcrystalline cellulose, aluminum methoxide and agar, or mixtures of these substances and the like.
- suspending agents such as ethoxylated isostearyl alcohols, polyoxyethylene sorbitol and sorbitan esters, microcrystalline cellulose, aluminum methoxide and agar, or mixtures of these substances and the like.
- compositions for parenteral injection may comprise physiologically acceptable sterile aqueous or anhydrous solutions, dispersions, suspensions or emulsions, and sterile powders for reconstitution into sterile injectable solutions or dispersions.
- Suitable aqueous and non-aqueous carriers, diluents, solvents or excipients include water, ethanol, polyols and suitable mixtures thereof.
- Dosage forms for topical administration of the compounds of this invention include ointments, powders, patches, sprays and inhalants.
- the active ingredient is mixed under sterile conditions with a physiologically acceptable carrier and any preservatives, buffers, or propellants that may be required if necessary.
- the compounds of the present invention may be administered alone or in combination with other pharmaceutically acceptable compounds.
- a safe and effective amount of the compound of the present invention is suitable for mammals (such as human beings) in need of treatment, and the dose is the effective dose considered pharmaceutically, for a 60kg body weight, the daily dose is
- the administration dose is usually 1 to 2000 mg, preferably 5 to 500 mg.
- the specific dosage should also take into account the route of administration, the patient's health and other factors, which are all within the skill of the skilled physician.
- the compounds of the present invention have good permeability, are non-p-glycoprotein transport substrates, have no efflux, have good druggability, and achieve unexpected and excellent technical effects.
- the compounds of the present invention can degrade Btk activity at very low concentrations.
- the present invention provides a pharmaceutical composition for treating diseases related to Btk enzyme activity.
- the compounds of the present invention not only have significant degrading activity on wild-type BTK, but also the BTK-C481S mutant protein has excellent degrading activity.
- the resistance value of the formed continuous monolayer film is greater than 100 ⁇ cm 2 , and the transport experiment is carried out within 3-5 days.
- VA the volume in the receiving chamber
- area is the surface area of the membrane
- time is the total transit time in seconds.
- Drug molecules from the apical side (AP side) of the Caco-2 monolayer across the monolayer or via the intercellular space to the basal side (BL side) are A to B, and vice versa, B to A, efflux ratio: Papp(B-A )/Papp(A-B).
- the experimental results show that the present invention has good permeability, non-p-glycoprotein transport substrate, no efflux phenomenon, and good druggability.
- the Jeko-1 cell line was cultured in an RPMI-1640 medium containing 20% fetal bovine serum at 37° C., 5% CO 2 , and a saturated humidity incubator. After the cells grew to the logarithmic growth phase, 5 ⁇ 10 6 cells per well were inoculated into a 6-well culture plate, and the DMSO control group and the compound test group were set.
- the TMD8 (BTK-C481S) mutant cell line was cultured in an RPMI-1640 medium containing 20% fetal bovine serum at 37° C., 5% CO 2 , and a saturated humidity incubator. After the cells grew to the logarithmic growth phase, 5 ⁇ 10 6 cells per well were inoculated into a 6-well culture plate, and the DMSO control group and the compound test group were set.
- TMD8 human lymphoma cells
- RPMI-1640 complete medium containing 10% fetal bovine serum and 1% penicillin-streptomycin at 37°C, 5% Incubator culture under CO 2 and saturated humidity conditions.
- TMD8 BTK-C481S mutant cells in logarithmic growth phase, after centrifugation, add an appropriate amount of complete medium to obtain a single cell suspension, count the cells with a hemocytometer, and prepare 1.5 ⁇ 10 5 cells/cell mL of cell suspension was inoculated into a 96-well culture plate with 100 ⁇ L of cell suspension per well, and placed in a CO 2 cell incubator for 24 h.
- CCK-8 detection 72h after administration, add 10% CCK-8 solution to each well, place in a CO2 cell incubator, and incubate for 1-4h. The absorbance of each well was measured at 450 nm using a microplate reader.
- OCI-LY10 cells were cultured in RPMI-1640 medium containing 10% fetal bovine serum FBS. Cells were cultured at 37°C in a 5% CO2 incubator.
- Cell inoculation method to establish tumor SCID mouse subcutaneous transplantation model collect tumor cells in logarithmic growth phase, resuspend in RPMI-1640 medium after counting, add Matrigel at 1:1, adjust the concentration of cell suspension to 4 ⁇ 10 7 cells cells/ml. Tumor cells were inoculated subcutaneously on the right back of SCID mice with a 1 ml syringe, 4 ⁇ 10 6 cells/0.1 ml/mouse.
- mice with too large, too small or irregular tumor shapes were eliminated, and tumor-bearing mice with a tumor volume of 101.34 to 209.86 mm 3 were selected, and the animals were grouped by random block method, and they were modeled respectively.
- the calculation formula is as follows:
- Tumor inhibition rate [1-(tumor volume on Day14-tumor volume on Day0 administration)/tumor volume on Day0 administration]*100%
Abstract
Description
化合物 | 降解BTK活性DC 50(nM) |
化合物1 | 2.3 |
化合物2 | 1.5 |
化合物4 | 12.3 |
化合物 | 降解BTK-C481S活性DC 50(nM) |
化合物1 | 9.9 |
化合物2 | 3.1 |
化合物4 | 17 |
化合物 | IC 50(nM) |
依鲁替尼 | 125 |
化合物1 | 7.1 |
化合物2 | 17.7 |
化合物 | 抑瘤率 |
化合物1 | 175% |
化合物2 | 189% |
Claims (10)
- 一种药物组合物,其特征在于,所述的组合物含有权利要求1所述的化合物或其药学上可接受的盐、前药、溶剂合物、氘代化合物,以及药学上可接受的载体。
- 如权利要求3所述的药物组合物,其特征在于,所述药物组合物,还包含另外一种或多种抗肿瘤剂。
- 如权利要求3所述的药物组合物,其特征在于,所述的药物组合物用于抑制布鲁顿酪氨酸蛋白激酶(Btk)的活性或降低布鲁顿酪氨酸蛋白激酶(Btk)的水平。
- 如权利要求3所述的药物组合物,其特征在于,所述的药物组合物用于治疗布鲁顿酪氨酸蛋白激酶(Btk)活性或表达量相关的疾病。
- 一种如权利要求1所述的化合物或其药学上可接受的盐的用途,用于:(a)制备治疗与布鲁顿酪氨酸蛋白激酶(Btk)活性或表达量相关的疾病的药物;(b)制备布鲁顿酪氨酸蛋白激酶(Btk)靶向抑制剂或降解剂;(c)体外非治疗性地抑制或降解布鲁顿酪氨酸蛋白激酶(Btk)的活性;(d)体外非治疗性地抑制肿瘤细胞增殖;和/或(e)治疗与布鲁顿酪氨酸蛋白激酶(Btk)活性或表达量相关的疾病。
- 如权利要求7所述的用途,其特征在于,所述的疾病包括肿瘤、自身免疫疾病。
- 如权利要求8所述的用途,其特征在于,所述肿瘤包括非霍奇金淋巴瘤(NHL)、慢性淋巴细胞白血病(CLL)、B细胞淋巴瘤等;所述自身免疫疾病包括类风湿性关节炎、银屑病等。
- 一种抑制或降解布鲁顿酪氨酸蛋白激酶(Btk)活性的方法,包括步骤:对抑制对象施用抑制有效量的如权利要求1所述的化合物或其药学上可接受的盐,或对抑制对象施用抑制有效量的如权利要求3所述的药物组合物。
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CN114478532A (zh) | 2022-05-13 |
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