WO2022073099A1 - Écouvillon à revêtement métallique nano pour la détection de traces - Google Patents
Écouvillon à revêtement métallique nano pour la détection de traces Download PDFInfo
- Publication number
- WO2022073099A1 WO2022073099A1 PCT/CA2021/051344 CA2021051344W WO2022073099A1 WO 2022073099 A1 WO2022073099 A1 WO 2022073099A1 CA 2021051344 W CA2021051344 W CA 2021051344W WO 2022073099 A1 WO2022073099 A1 WO 2022073099A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- swab
- coating
- metal
- substrate
- certain embodiments
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N2001/022—Devices for withdrawing samples sampling for security purposes, e.g. contraband, warfare agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N2001/028—Sampling from a surface, swabbing, vaporising
Definitions
- the present invention relates to chemical trace detection.
- the present invention relates to swabs for collection of samples for trace detection.
- Trace analyte detection is the detection of small amounts of analytes, often at nanogram to picogram levels. Trace analyte detection has numerous applications, such as screening individuals and baggage at transportation centers, mail screening, facility security applications, military applications, forensics applications, narcotics detection and identification, cleaning validation, quality control, and raw material identification. Trace analyte detection can be particularly useful for security applications such as screening individuals or items for components in explosive materials, narcotics or biological contaminants where small amounts of these components are deposited on the individual or on the outside of a package or bag.
- Swabs are designed to harvest particles from surfaces (like as container, luggage, bag, etc.) for analysis by the trace detection instrument.
- the sample collection process entails the use of specific procedures regarding the item to be sampled with trap passes proceeding in a logical fashion across the item to be swabbed to ensure complete sample gathering.
- Explosive Trace Detection (ETD) swabs material is designed for use in the ETD device which requires high temperatures to burn off trace elements for identification by the system. Trace detection is based upon the chemical analysis of explosive residues resulting from bomb building or concealment or any encounter with the components of explosives. Similarly, narcotic trace detection is predicated upon the chemical analysis of subject encounters with narcotic component.
- detection technologies such as mass spectrometry, gas chromatography, chemical luminescence, or ion mobility spectrometry, measure the chemical properties of vapor for detection. These technologies use heat to vapor explosive chemical (up to 300°C) which makes heat transferring of swabs critical for detection process.
- An object of the present invention is to provide a metalized nano coated swab for trace detection.
- a swab comprising a substrate material and a coating.
- the substrate is nonwoven, woven or a film.
- the coating is a metal.
- the coating is a high surface energy material.
- the coating has high thermal conductivity properties.
- the coating is a metal selected from the group consisting of copper, aluminum, silver, gold and combinations thereof.
- a method of manufacturing the swab comprising coating a substrate with a metal.
- coating is by vapor deposition, E beam deposition or sputtering.
- a swab produced by the methods of the invention.
- a method of collecting trace analyte samples comprising contacting a surface with the swab of the invention.
- the analyte is an explosive.
- the analyte is a narcotic.
- Figure 1 presents a nonwoven substrate with more surface area.
- Figure 2 presents a close up view of a nonwoven substrate with more surface area.
- Figure 3 presents surface energy of different materials.
- Figure 4 presents thermal conductivity of different materials.
- Figure 5 presents a metallizing process which utilizes vapor deposition
- Figure 6 presents a metallizing process which utilizes sputtering.
- the present invention provides a coated material, e.g. a coated swab, which may be used for sample collection in trace analyte detection.
- Trace detection reliability and accuracy may be improved by improving the collection (harvesting) capabilities of the swab used for sample collection and/or improving the transferring properties of the swab used for sample collection.
- the swabs of the present invention have improved collecting efficiency (harvesting) as compared to uncoated swabs (manufactured from the same material as the substrate material of the coated swab).
- the swabs of the present invention have improved transferring properties as compared to uncoated swabs.
- the swabs of the present invention have improved collecting efficiency (harvesting) and improved transferring properties as compared to uncoated swabs.
- the swab of the present invention comprises a substrate material and a coating.
- the substrate may be nonwoven, woven or a film.
- Exemplary materials include but are not limited to cotton, Nomex® and polyamide membrane surfaces.
- exemplary materials include but are not limited to polyester point bonded, Spunlace, needlepunch nonwoven with (30 up to 250 gsm).
- a swab’s harvesting efficiency is in part related to surface roughness.
- swabs with a rough surface will likely collect more trace material due to increased surface area as compared to a swab of the same size having a smooth surface.
- the surface roughness may be impacted by the components of the substrate and the manufacturing process of the substrate.
- the surface roughness of a woven substrate may be impacted by the fiber used and/or the weave.
- the surface roughness of non-woven fibrous materials may be impacted by the fiber used and/or manufacturing process. Mechanical or chemical treatments may be used to enhance surface roughness of films.
- the substrate is coated with a coating.
- the coating is a metal.
- the metal may be one metal or a combination of metals.
- a swab’s harvesting efficiency is also in part related to its surface energy.
- a swab’s surface energy may be increase by coating the surface with a High Surface Energy Material.
- Exemplary materials include but are not limited metals such as aluminum, copper, silver, gold and zinc. (Table 1 - Surface Energy). Accordingly, in certain embodiments, the coating is a high surface energy material. In certain embodiments, the high surface energy material is a metal. In specific embodiments, the metal is selected from the group consisting of aluminum, copper, silver, gold, zinc and combinations thereof.
- Typical detection technique involves thermally driving a sample into a detector. Accordingly, swabs with higher heat transferring may improve the detection process. Accordingly, in certain embodiments, the coating has high thermal conductivity properties.
- the material having high thermal conductivity properties is a metal. In specific embodiments, the metal is selected from the group consisting of copper, aluminum, silver, gold and combinations thereof.
- the coating material is a metal with high surface energy and high thermal conductivity.
- the coating is a metal selected from the group consisting of copper, aluminum, silver, gold and combinations thereof.
- the present invention further provides a method of manufacturing the swab.
- the method comprises coating the substrate with a metal.
- vacuum coating is used to coat the substrate.
- a variety of techniques are known in the art to coat a substrate.
- the methods are performed under low pressure.
- the methods are performed in an ultra low-pressure vacuum chamber. Nonlimiting examples include but are not limited to vapor deposition, E-beam and sputtering
- the method comprises coating the substrate with a metal by vapor deposition.
- a metal such as a metal wire
- metal is fed into a heated tub causing it to melt. Because of the low chamber pressure, the melting point of the metal wire is far lower than it would be under normal conditions. When the metal boils, a vapor is formed which will adhere to a piece of substrate passing through the chamber.
- the amount of metal applied to the substrate is determined by the speed at which the substrate passes through the chamber. By adjusting speeds, the density of the metal applied to the substrate may be altered. This allows for the creation of swabs with varying degrees of metallization. Generally speaking, the longer the exposure to vapor, the thicker the metal coating on the substrate.
- the method comprises coating the substrate with a metal by E beam deposition.
- a metal by E beam deposition.
- E beam deposition A worker skilled in the art would readily appreciate that this process is similar to the vapor deposition procedure except the metal is not placed in a heated tub. Instead, an electron beam is used to heat the metal wire.
- the method comprises coating the substrate with a metal by sputtering.
- a low-pressure vacuum chamber is used to create a gas atmosphere. Electrical energy is then used to create a negative charge to the gas molecules. The vacuum pressure allows the subsequent gas molecule particles to move freely and rapidly about the chamber. When these charged particles collide with a metal “cathode”, small particles of the metal are chipped off the cathode and subsequently deposited on the substrate. Similar to the vapor coating method, the speed at which the substrate travels through the chamber determines the density of the metal on the substrate.
- the swabs of the present invention are useful for collecting samples containing of a wide range of analytes, including but not limited to explosives, narcotics, chemical warfare agents, toxins, pharmaceutical process contaminants, and other chemical compounds.
- the swab is for collection of samples for trace explosive detection.
- Explosives which may be collected using a swab include, but are not limited to, 2-amino-4,6- dinitrotoluene, 4-amino-2,6-dinitrotoluene, ammonal, ammonium nitrate, black powder, 2,4- dimethyl-1 ,3-dinitrobutane, 2,4-dinitrotoluene, ethylene glycol dinitrate, forcite 40, GOMA-2, hexanitrostilbene, 1 ,3,5,7-tetranitro-1 ,3,5,7-tetrazacyclooctane (HMX), mononitrotoluene, nitroglycerine, pentaerythritol tetranitrate (PETN), 1 ,3,5-trinitro-1 ,3,5-triazacyclohexane (RDX), semtex-A, Semtex-H, smokeless powder,
- the explosive which are collected are 1 ,3,5-trinitro- 1 ,3,5-triazacyclohexane, pentaerythritol tetranitrate, 2,4,6-trinitrotoluene, trinitro-2,4,6- phenylmethylnitramine tetryl, nitroglycerine, ammonium nitrate, 3,5,7-tetranitro-1 ,3,5,7- tetrazacyclooctane, and combinations thereof.
- the swab is for collection of samples for trace narcotic detection.
- Narcotics which may be collected using a swab include, but are not limited to 6- acetylmorphine, alprazolam, amobarbital, amphetamine, antipyrine, benzocaine, benzoylecgonine, bromazepam, butalbital, carbetapentane, cathinone, chloradiazepoxide, chlorpheniramine, cocaethylene, ***e, codeine, diazepam, ecgonine, ecognine methyl ester (EME), ephedrine, fentanyl, flunitrazepam, hashish, heroin, hydrocodone, hydromorphone, ketamine, lidocaine, lorazepam, lysergic acid diethylamide (LSD), lysergic acid, N-methyl-1-3(3,4-methylenedioxyohenyl)-2-butanamine (MB
- the narcotics which can be collected with a swab include ***e, heroin, phencyclidine, THC, methamphetamine, methylenedioxyethylamphetamine, methylenedioxymethamphetamine, N-methyl-1-3(3,4-methylenedioxyohenyl)-2-butanamine, lysergic acid diethylamide, and combinations thereof.
- the swab is for collection of samples for trace detection of chemical warfare agents and other toxins.
- Chemical warfare agents and other toxins that may be collected using a swab include, but are not limited to amiton (VG), anthrax, arsine, cyanogen chloride, hydrogen chloride, chlorine, diphosgene, PFIB, phosgene, phosgene oxime, chloropicrin, ethyl N,N-dimethyl phosphoramicocyanidate (Tabun), isopropyl methyl phosphonofluoridate (Sarin), pinacolyl methyl phosphonefluoridate (Soman), phosphonofluoridic acid, ethyl-, isopropyl ester (GE), phosphonothioic acid, ethyl-, S-(2- (diethylamino)ethyl) O-ethyl ester (VE), phosphonothioic acid, methyl-, S-
- Sample analytes can be collected onto a swab by any suitable means.
- a sample containing analytes of interest can be collected onto a swab by direct contact of the swab with the surface to be tested, e.g., by mechanical agitation or frictional contact.
- Direct contact can be achieved by direct manual contact of an article with the swab or insertion of swab material into a holder which manually or automatically directly contacts an article with the swab material.
- a surface to be tested can include any surface of a person or object.
- the surface can be a surface of a personal effect, clothing, bag, luggage, furniture, automobile interior, pharmaceutical process equipment, etc.
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- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
La présente invention concerne un écouvillon comprenant un matériau de substrat et un revêtement métallique. L'invention concerne également des procédés de fabrication de l'écouvillon. L'écouvillon peut être utilisé pour la collecte d'échantillons d'analyte à l'état de trace, notamment d'explosifs et de narcotiques.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063088083P | 2020-10-06 | 2020-10-06 | |
US63/088,083 | 2020-10-06 |
Publications (1)
Publication Number | Publication Date |
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WO2022073099A1 true WO2022073099A1 (fr) | 2022-04-14 |
Family
ID=81127073
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/CA2021/051344 WO2022073099A1 (fr) | 2020-10-06 | 2021-09-28 | Écouvillon à revêtement métallique nano pour la détection de traces |
Country Status (1)
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WO (1) | WO2022073099A1 (fr) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2134217C (fr) * | 1992-05-19 | 2000-04-11 | Robert Edward Burrell | Revetement antimicrobien destine aux instruments medicaux |
CA2118713C (fr) * | 1991-09-13 | 2006-08-22 | Raouf A. Guirguis | Analyse combinant simultanement la detection d'un medicament et l'analyse d'empreintes genetiques |
US20160084740A1 (en) * | 2014-09-18 | 2016-03-24 | Purdue Research Foundation | Engineered detection swab |
-
2021
- 2021-09-28 WO PCT/CA2021/051344 patent/WO2022073099A1/fr active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2118713C (fr) * | 1991-09-13 | 2006-08-22 | Raouf A. Guirguis | Analyse combinant simultanement la detection d'un medicament et l'analyse d'empreintes genetiques |
CA2134217C (fr) * | 1992-05-19 | 2000-04-11 | Robert Edward Burrell | Revetement antimicrobien destine aux instruments medicaux |
US20160084740A1 (en) * | 2014-09-18 | 2016-03-24 | Purdue Research Foundation | Engineered detection swab |
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