WO2022062050A1 - Oct imaging system suitable for all-round dynamic determination of schlemm's canal of anterior chamber angle outflow channel - Google Patents

Oct imaging system suitable for all-round dynamic determination of schlemm's canal of anterior chamber angle outflow channel Download PDF

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Publication number
WO2022062050A1
WO2022062050A1 PCT/CN2020/124352 CN2020124352W WO2022062050A1 WO 2022062050 A1 WO2022062050 A1 WO 2022062050A1 CN 2020124352 W CN2020124352 W CN 2020124352W WO 2022062050 A1 WO2022062050 A1 WO 2022062050A1
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fiber coupler
light
reference arm
optical fiber
schlemm
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PCT/CN2020/124352
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French (fr)
Chinese (zh)
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沈梅晓
陈思思
朱德喜
邵一磊
吕帆
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温州医科大学
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Publication of WO2022062050A1 publication Critical patent/WO2022062050A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/102—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for optical coherence tomography [OCT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/117—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for examining the anterior chamber or the anterior chamber angle, e.g. gonioscopes

Definitions

  • the invention relates to the technical field of medical instruments, in particular to a transmissive reference arm and a swept frequency domain optical coherence tomography system and a method thereof designed to achieve high penetration and high resolution without a circulator, which are suitable for Schlemm's angle outflow channel Schlemm's Tube dynamic determination.
  • Glaucoma has become the second leading cause of blindness in the world after cataract, and the first cause of irreversible blindness.
  • the specific pathogenesis has not yet been elucidated, but it is currently clear that elevated intraocular pressure (IOP) is the most important risk factor for glaucoma, and the resistance change of the aqueous outflow tract (mainly the trabecular meshwork outflow channel) affects the change of IOP. major factor.
  • IOP intraocular pressure
  • SC Schlemm canal
  • SC is an important pathway for the drainage of aqueous humor into the circulatory system, and is also an important structure for maintaining the blood-aqueous humor barrier in the anterior chamber.
  • the resistance provided by this part accounts for 75%-90% of the total outflow channel resistance. At present, theories have revealed the reasons for its resistance, such as the size of the lumen and the density of the small holes.
  • OCT is a new imaging technology based on the principle of low-coherence optical interference. It has the characteristics of high-resolution non-contact and non-destructive detection, and is widely used in the field of medical imaging.
  • Spectral domain OCT uses the spectrometer detection system to obtain the interference spectral signal, and obtains the depth information by the Fourier transform method, thereby further improving the imaging speed and imaging sensitivity.
  • the existing OCT technology is limited by factors such as scanning speed, penetration depth, and resolution, and can only perform static measurement of local low-resolution OCT.
  • the present invention provides an OCT imaging system suitable for the dynamic measurement of the whole circumference of Schlemm's canal of the angle outflow channel.
  • an OCT imaging system suitable for the full circumference dynamic measurement of the Schlemm's tube of the angle outflow channel, comprising a control center, a light source, a first optical fiber coupler, a sample arm, a reference arm, and a second optical fiber coupler , the third fiber coupler, balanced detector;
  • the light source is used for outputting light
  • the first fiber coupler is arranged corresponding to the light source, and the light is divided into the sample arm light and the reference arm light after passing through the first fiber coupler, the sample arm light enters the sample arm, and the reference arm light enters the reference arm;
  • the second optical fiber coupler is arranged corresponding to the reference arm, and the light of the reference arm is transmitted to the second optical fiber coupler after passing through the reference arm;
  • the third fiber coupler is arranged corresponding to the first fiber coupler and the second fiber coupler, and the reflected light of the sample arm light and the reference arm light can interfere in the third fiber coupler;
  • the balanced detector is connected with the third fiber coupler and the control center, and can extract the signal and send it to the control center.
  • the light source is a frequency swept source light source with a center wavelength of 1060 nm and a broadband of 100 nm, and a scanning speed of 200 kHz, and the light source is connected to the control center.
  • the reference arm includes a first collimating mirror and a second collimating mirror.
  • the first collimating mirror is arranged corresponding to the first optical fiber coupler
  • the second collimating mirror is arranged corresponding to the second optical fiber coupler
  • the light of the reference arm passes through the first optical fiber coupler. After a collimating mirror is projected, the second collimating mirror is received into the second optical fiber coupler.
  • the reference arm also includes a dispersion compensator.
  • the reference arm further includes a first reflection mirror and a second reflection mirror, and the first reflection mirror and the second reflection mirror are symmetrically arranged.
  • the second fiber coupler is connected with a polarization controller.
  • the sample arm includes a third collimating mirror, a first scanning galvanometer, a first lens, a second lens, a second scanning galvanometer, and a third lens.
  • the mirror, the first lens, the second lens, the second scanning galvanometer, and the third lens enter the human eye for reflection.
  • the beneficial effects of the present invention are: adopting the above scheme, using the transmissive reference arm structure, does not need to use a circulator, thereby avoiding the narrow bandwidth limitation of the circulator, retaining the axial resolution to the maximum extent, and realizing the observation and detection of Schlemm's tube. Measurement.
  • FIG. 1 is a schematic structural diagram of an OCT imaging system according to an embodiment of the present invention.
  • FIG. 2 is a schematic structural diagram of a sample arm according to an embodiment of the present invention.
  • FIG. 3 is a schematic structural diagram of a reference arm according to an embodiment of the present invention.
  • an OCT imaging system suitable for the dynamic measurement of the whole circumference of Schlemm's tube in the angle outflow channel includes a control center 1, a light source 2, a first optical fiber coupler 3, a sample arm 4, a reference arm 5, and a second optical fiber Coupler 6 , third fiber coupler 7 , balanced detector 8 .
  • the control center 1 is a computer, which is used for control and subsequent image analysis and processing.
  • the light source 2 is a swept frequency source light source with a central wavelength of 1060 nm and a broadband of 100 nm, the scanning speed is 200 kHz, and the 1060 nm can penetrate the sclera and the pigmented tissue of the anterior segment of the eye to reach Schlemm's tube.
  • the light source 2 is connected to the control center 1, and can be Under the control and feedback of the control center 1, light waves of different wavelengths are periodically emitted in a short period of time, and the speed can reach hundreds of thousands of hertz or even higher, and the Schlemm tube can be quickly and dynamically measured at different eye positions.
  • the first fiber coupler 3 is arranged in front of the light source 2 , and the light is divided into sample arm light and reference arm light after passing through the first fiber coupler 3 .
  • the sample arm light enters the sample arm 4
  • the reference arm light enters the reference arm 5 .
  • the sample arm 4 includes a third collimating mirror 41, a first scanning galvanometer 42, a first lens 43, a second lens 44, a second scanning galvanometer 45, and a third lens 46, and the light of the sample arm passes through the third collimator in sequence.
  • the straight mirror 41 , the first scanning galvanometer 42 , the first lens 43 , the second lens 44 , the second scanning galvanometer 45 , and the third lens 46 are reflected after entering the human eye.
  • the first scanning galvanometer 42 and the second scanning galvanometer 45 can turn the light of the sample arm, and the first lens 43 and the second lens 44 have the same focal length, so as to realize the 4F imaging of the scanning galvanometer and reduce the optical distortion.
  • the three lenses 46 are used for focal length adjustment, so that the focal length of the light from the sample arm can fall on the position required for imaging.
  • the reference arm 5 includes a first collimating mirror 51, a dispersion compensator 53, a first reflecting mirror 54, a second reflecting mirror 55, and a second collimating mirror 52 arranged in sequence.
  • An optical fiber coupler 3 is correspondingly arranged, which can receive the light of the reference arm and project it.
  • the light of the reference arm projected by the first collimating mirror 51 is compensated by the dispersion compensator 53 to compensate the optical path of the lens in the corresponding sample arm area.
  • the first reflecting mirror 54 and the second reflecting mirror 55 are symmetrically arranged, which can deflect the light reference arm, thereby reducing the space occupied.
  • the first collimating mirror 51 , the dispersion compensator 53 , the first reflecting mirror 54 and the second reflecting mirror 55 are then received by the second collimating mirror 52 to the second fiber coupler 6 .
  • the second optical fiber coupler 6 is used for optical path difference matching, which is selected according to the length requirement and the reflected light intensity of the reference arm, so as to realize the optical path difference matching between the sample arm and the reference arm.
  • the second fiber coupler 6 is connected with a polarization controller 9 to adjust the polarization properties of the light.
  • the third fiber coupler 7 is arranged corresponding to the first fiber coupler 3 and the second fiber coupler 6, and can receive the reflected light of the sample arm light and the reference arm light.
  • the reflected light of the sample arm light and the reference arm light The light can interfere with each other, and the third fiber coupler 7 should choose the spectroscopic efficiency specification of 50:50.
  • the balanced detector 8 is connected to the third fiber coupler 7 and the control center 1, and can extract the signal and send it to the control center 1.
  • the balanced detector 8 can eliminate the common mode noise by subtracting the two optical input signals to avoid interference. When extracting from the noise floor, the variation in the optical signal path is reduced and the subsequent signal processing analysis is performed by the control center 1.
  • the imaging process of the above-mentioned OCT imaging system suitable for the full circumference dynamic measurement of the Schlemm's tube of the angle outflow channel is as follows: the light source 2 emits light, and the light is divided into two after passing through the first fiber coupler 3, one of which is the sample arm light, and the sample The arm light enters the human eye after passing through the third collimating mirror 41, the first scanning galvanometer 42, the first lens 43, the second lens 44, the second scanning galvanometer 45, and the third lens 46 in turn, forming the reflected light according to the original path.
  • the other beam After returning to the first fiber coupler 3 and entering the third fiber coupler 7, the other beam is the reference arm light, and the reference arm light passes through the first collimating mirror 51, the dispersion compensator 53, the first reflecting mirror 54, the second The mirror 55, the second collimating mirror 52, and the second fiber coupler 6 then enter the third fiber coupler 7, where the reflected light of the sample arm light and the reference arm light interfere, and then the balance detector 8 passes through the two Optical input signal subtraction eliminates common-mode noise, reduces changes in the optical signal path when extracted from the interference noise floor, and conducts subsequent signal processing and analysis through control center 1.
  • the use of the transmissive reference arm structure eliminates the need to use a circulator, thereby avoiding the narrow bandwidth limitation of the circulator and maximizing the preservation of the axial resolution, thereby realizing the observation and measurement of Schlemm’s tube.
  • the terms “installed”, “connected” and “connected” should be understood in a broad sense, unless otherwise expressly specified and limited, for example, it may be a fixed connection or a detachable connection Connection, or integral connection; can be mechanical connection, can also be electrical connection; can be directly connected, can also be indirectly connected through an intermediate medium, can be internal communication between two elements.
  • installed should be understood in a broad sense, unless otherwise expressly specified and limited, for example, it may be a fixed connection or a detachable connection Connection, or integral connection; can be mechanical connection, can also be electrical connection; can be directly connected, can also be indirectly connected through an intermediate medium, can be internal communication between two elements.
  • the specific meanings of the above terms in the present invention can be understood in specific situations.
  • “plurality” means two or more.

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Abstract

An OCT imaging system suitable for all-round dynamic determination of a Schlemm's canal of an anterior chamber angle outflow channel; a light source (2) can emit a light ray to a first optical fiber coupler (3); the light ray is divided into a sample arm light ray and a reference arm light ray after passing through the first optical fiber coupler (3); the sample arm light ray enters a sample arm (4); the reference arm light ray enters a reference arm (5), and the reference arm light ray is transmitted to a second optical fiber coupler (6) after passing through the reference arm (5); reflected light of the sample arm light ray and the reference arm light ray can interfere with each other in a third optical fiber coupler (7); and a balancing detector (8) connects the third optical fiber coupler (7) and a control center (1), and can extract a signal and send the signal to the control center (1). The OCT imaging system uses a transmissive reference arm (5) structure without using a circulator, avoiding the limitation of a narrow broadband of the circulator, retaining an axial resolution to the maximum extent, thereby achieving the observation and measurement of a Schlemm's canal.

Description

适用于房角流出通道Schlemm’s管全周动态测定的OCT成像***OCT imaging system suitable for dynamic determination of Schlemm's canal in angle outflow channel 技术领域technical field
本发明涉及医疗仪器技术领域，具体涉及一种透射式的参考臂和无环形器设计实现高穿透高分辨率的扫频域光学相干层析成像***及其方法，适用于房角流出通道Schlemm’s管全周动态测定。The invention relates to the technical field of medical instruments, in particular to a transmissive reference arm and a swept frequency domain optical coherence tomography system and a method thereof designed to achieve high penetration and high resolution without a circulator, which are suitable for Schlemm's angle outflow channel Schlemm's Tube dynamic determination.
背景技术Background technique
青光眼已成为继白内障之后的全球第二大致盲性眼病，同时也是第一位不可逆致盲性眼病。具体发病机制仍未阐明清楚，但目前可以明确眼内压（IOP）升高是青光眼发病的最重要危险因素，而房水流出道（主要是小梁网流出通道）的阻力改变是影响IOP改变的主要因素。经过140余年的研究，虽然取得了一系列的进展，明确了房水流出主要的阻力部位在于Schlemm管（Schlemm canal，SC），SC又称巩膜静脉窦，房水通过小梁网进入SC后，经过集液管汇入巩膜内静脉。SC是将房水汇入循环***的重要通路，也是前房内维持血-房水屏障的重要结构。该部位所提供的阻力占总流出通道阻力的75%-90%。目前，已有理论揭示其产生阻力的原因，如管腔大小、小孔的密度等。Glaucoma has become the second leading cause of blindness in the world after cataract, and the first cause of irreversible blindness. The specific pathogenesis has not yet been elucidated, but it is currently clear that elevated intraocular pressure (IOP) is the most important risk factor for glaucoma, and the resistance change of the aqueous outflow tract (mainly the trabecular meshwork outflow channel) affects the change of IOP. major factor. After more than 140 years of research, although a series of progress has been made, it is clear that the main resistance of aqueous humor outflow is Schlemm canal (SC), SC is also known as Schlemm canal. After aqueous humor enters SC through trabecular meshwork, It drains into the internal scleral vein through the collecting tube. SC is an important pathway for the drainage of aqueous humor into the circulatory system, and is also an important structure for maintaining the blood-aqueous humor barrier in the anterior chamber. The resistance provided by this part accounts for 75%-90% of the total outflow channel resistance. At present, theories have revealed the reasons for its resistance, such as the size of the lumen and the density of the small holes.
目前已有的检测和评价方法均存在一定局限性。在早期对于SC的探索中，由于SC位置隐蔽、体积很小，加上技术的限制，长期以来，人们对小梁网和Schlemm’s管的研究主要是离体的手段，包括普通光学显微镜（光镜）和激光扫描共聚焦显微镜等方法。这些方法能很好的反映小梁网和Schlemm’s管的离体形态，但却不能反映小梁网和Schlemm’s管在体的功能。在体评估的方法目前包括UBM和OCT。其中UBM操作时，超声探头需要接触检查区域，对眼球具有一定压迫，可能导致Schlemm’s管的细微形态改变，仍然存在一定的局限性。OCT是一种基于低相干光学干涉原理的新型成像技术，具有高分辨率非接触性和无损探测等特点，广泛应用于医学成像领域。谱域OCT利用光谱仪探测***获取干涉光谱信号，经傅里叶变换的方法获取深度信息，从而进一步提高了成像速度和成像灵敏度。但目前已有的OCT技术受限于扫描速度和穿透深度、分辨率等因素，仅能对OCT进行局部较低分辨率的静态测定。The existing detection and evaluation methods have certain limitations. In the early exploration of SC, due to the hidden position, small size of SC, and technical limitations, for a long time, people's research on trabecular meshwork and Schlemm's canal was mainly in vitro, including ordinary optical microscopy (light microscope). ) and laser scanning confocal microscopy. These methods can well reflect the in vitro morphology of the trabecular meshwork and Schlemm's canal, but cannot reflect the function of the trabecular meshwork and Schlemm's canal in vivo. Methods for in vivo assessment currently include UBM and OCT. Among them, during UBM operation, the ultrasound probe needs to touch the examination area, which has a certain pressure on the eyeball, which may lead to subtle morphological changes of Schlemm’s canal, and there are still certain limitations. OCT is a new imaging technology based on the principle of low-coherence optical interference. It has the characteristics of high-resolution non-contact and non-destructive detection, and is widely used in the field of medical imaging. Spectral domain OCT uses the spectrometer detection system to obtain the interference spectral signal, and obtains the depth information by the Fourier transform method, thereby further improving the imaging speed and imaging sensitivity. However, the existing OCT technology is limited by factors such as scanning speed, penetration depth, and resolution, and can only perform static measurement of local low-resolution OCT.
技术解决方案technical solutions
为了克服背景技术的不足，本发明提供一种适用于房角流出通道Schlemm’s管全周动态测定的OCT成像***。In order to overcome the deficiencies of the background art, the present invention provides an OCT imaging system suitable for the dynamic measurement of the whole circumference of Schlemm's canal of the angle outflow channel.
本发明所采用的技术方案：一种适用于房角流出通道Schlemm’s管全周动态测定的OCT成像***，包括控制中心、光源、第一光纤耦合器、样品臂、参考臂、第二光纤耦合器、第三光纤耦合器、平衡探测器；The technical solution adopted in the present invention: an OCT imaging system suitable for the full circumference dynamic measurement of the Schlemm's tube of the angle outflow channel, comprising a control center, a light source, a first optical fiber coupler, a sample arm, a reference arm, and a second optical fiber coupler , the third fiber coupler, balanced detector;
所述光源用于输出光线；the light source is used for outputting light;
所述第一光纤耦合器与光源对应设置，光线经第一光纤耦合器后分为样品臂光线与参考臂光线，样品臂光线进入样品臂，参考臂光线进入参考臂；The first fiber coupler is arranged corresponding to the light source, and the light is divided into the sample arm light and the reference arm light after passing through the first fiber coupler, the sample arm light enters the sample arm, and the reference arm light enters the reference arm;
所述第二光纤耦合器与参考臂对应设置，参考臂光线经过参考臂后输送至第二光纤耦合器；The second optical fiber coupler is arranged corresponding to the reference arm, and the light of the reference arm is transmitted to the second optical fiber coupler after passing through the reference arm;
所述第三光纤耦合器与第一光纤耦合器和第二光纤耦合器对应设置，样品臂光线的反射光与参考臂光线能在第三光纤耦合器中相干涉；The third fiber coupler is arranged corresponding to the first fiber coupler and the second fiber coupler, and the reflected light of the sample arm light and the reference arm light can interfere in the third fiber coupler;
所述平衡探测器连接第三光纤耦合器与控制中心，能提取信号并发送至控制中心。The balanced detector is connected with the third fiber coupler and the control center, and can extract the signal and send it to the control center.
所述光源为中心波长为1060nm、宽带100nm的扫频源光源，扫描速度为200kHz，所述光源与控制中心连接。The light source is a frequency swept source light source with a center wavelength of 1060 nm and a broadband of 100 nm, and a scanning speed of 200 kHz, and the light source is connected to the control center.
所述参考臂包括第一准直镜、第二准直镜，第一准直镜与第一光纤耦合器对应设置，第二准直镜与第二光纤耦合器对应设置，参考臂光线经第一准直镜投出后由第二准直镜接收至第二光纤耦合器中。The reference arm includes a first collimating mirror and a second collimating mirror. The first collimating mirror is arranged corresponding to the first optical fiber coupler, the second collimating mirror is arranged corresponding to the second optical fiber coupler, and the light of the reference arm passes through the first optical fiber coupler. After a collimating mirror is projected, the second collimating mirror is received into the second optical fiber coupler.
所述参考臂还包括色散补偿器。The reference arm also includes a dispersion compensator.
所述参考臂还包括第一反射镜、第二反射镜，所述第一反射镜与第二反射镜对称设置。The reference arm further includes a first reflection mirror and a second reflection mirror, and the first reflection mirror and the second reflection mirror are symmetrically arranged.
所述第二光纤耦合器连接有偏振控制器。The second fiber coupler is connected with a polarization controller.
所述样品臂包括第三准直镜、第一扫描振镜、第一透镜、第二透镜、第二扫描振镜、第三透镜，样品臂光线依次经过第三准直镜、第一扫描振镜、第一透镜、第二透镜、第二扫描振镜、第三透镜后进入人眼进行反射。The sample arm includes a third collimating mirror, a first scanning galvanometer, a first lens, a second lens, a second scanning galvanometer, and a third lens. The mirror, the first lens, the second lens, the second scanning galvanometer, and the third lens enter the human eye for reflection.
有益效果beneficial effect
本发明的有益效果是：采用以上方案，利用透射式的参考臂结构，无需使用环形器，从而避免了环形器的窄宽带限制，最大限度地保留轴向分辨率，从而实现Schlemm’s管的观察和测量。The beneficial effects of the present invention are: adopting the above scheme, using the transmissive reference arm structure, does not need to use a circulator, thereby avoiding the narrow bandwidth limitation of the circulator, retaining the axial resolution to the maximum extent, and realizing the observation and detection of Schlemm's tube. Measurement.
附图说明Description of drawings
图1为本发明实施例OCT成像***的结构示意图。FIG. 1 is a schematic structural diagram of an OCT imaging system according to an embodiment of the present invention.
图2为本发明实施例样品臂的结构示意图。FIG. 2 is a schematic structural diagram of a sample arm according to an embodiment of the present invention.
图3为本发明实施例参考臂的结构示意图。FIG. 3 is a schematic structural diagram of a reference arm according to an embodiment of the present invention.
本发明的实施方式Embodiments of the present invention
下面结合附图对本发明实施例作进一步说明：Embodiments of the present invention will be further described below in conjunction with the accompanying drawings:
如图所示，一种适用于房角流出通道Schlemm’s管全周动态测定的OCT成像***，包括控制中心1、光源2、第一光纤耦合器3、样品臂4、参考臂5、第二光纤耦合器6、第三光纤耦合器7、平衡探测器8。As shown in the figure, an OCT imaging system suitable for the dynamic measurement of the whole circumference of Schlemm's tube in the angle outflow channel includes a control center 1, a light source 2, a first optical fiber coupler 3, a sample arm 4, a reference arm 5, and a second optical fiber Coupler 6 , third fiber coupler 7 , balanced detector 8 .
所述控制中心1为电脑，用于控制以及后续图像的分析与处理。The control center 1 is a computer, which is used for control and subsequent image analysis and processing.
所述光源2为中心波长为1060nm、宽带100nm的扫频源光源，扫描速度为200kHz，1060nm可穿透巩膜与眼前段色素组织，达到Schlemm’s管，所述光源2与控制中心1连接，可在控制中心1的控制下和反馈下在短时间内周期性发射不同波长的光波，速度可达几十万赫兹甚至更高，可在不同眼位对Schlemm管进行快速动态测定。The light source 2 is a swept frequency source light source with a central wavelength of 1060 nm and a broadband of 100 nm, the scanning speed is 200 kHz, and the 1060 nm can penetrate the sclera and the pigmented tissue of the anterior segment of the eye to reach Schlemm's tube. The light source 2 is connected to the control center 1, and can be Under the control and feedback of the control center 1, light waves of different wavelengths are periodically emitted in a short period of time, and the speed can reach hundreds of thousands of hertz or even higher, and the Schlemm tube can be quickly and dynamically measured at different eye positions.
所述第一光纤耦合器3设置在光源2前方，光线经第一光纤耦合器3后分为样品臂光线与参考臂光线，样品臂光线进入样品臂4，参考臂光线进入参考臂5。The first fiber coupler 3 is arranged in front of the light source 2 , and the light is divided into sample arm light and reference arm light after passing through the first fiber coupler 3 . The sample arm light enters the sample arm 4 , and the reference arm light enters the reference arm 5 .
所述样品臂4包括第三准直镜41、第一扫描振镜42、第一透镜43、第二透镜44、第二扫描振镜45、第三透镜46，样品臂光线依次经过第三准直镜41、第一扫描振镜42、第一透镜43、第二透镜44、第二扫描振镜45、第三透镜46后进入人眼后进行反射。The sample arm 4 includes a third collimating mirror 41, a first scanning galvanometer 42, a first lens 43, a second lens 44, a second scanning galvanometer 45, and a third lens 46, and the light of the sample arm passes through the third collimator in sequence. The straight mirror 41 , the first scanning galvanometer 42 , the first lens 43 , the second lens 44 , the second scanning galvanometer 45 , and the third lens 46 are reflected after entering the human eye.
其中，第一扫描振镜42和第二扫描振镜45，能够使得样品臂光线发生转折，第一透镜43与第二透镜44焦距相同，从而实现扫描振镜的4F成像，减少光学畸变，第三透镜46则用于焦距调整，使样品臂光线的焦距能够落于成像所需的部位。Among them, the first scanning galvanometer 42 and the second scanning galvanometer 45 can turn the light of the sample arm, and the first lens 43 and the second lens 44 have the same focal length, so as to realize the 4F imaging of the scanning galvanometer and reduce the optical distortion. The three lenses 46 are used for focal length adjustment, so that the focal length of the light from the sample arm can fall on the position required for imaging.
所述参考臂5包括依次设置的第一准直镜51、色散补偿器53、第一反射镜54、第二反射镜55、第二准直镜52，所述第一准直镜51与第一光纤耦合器3对应设置，能够接收参考臂光线并将其投出，经第一准直镜51投出的参考臂光线经色散补偿器53对相应样品臂区域的透镜光程进行补偿，所述第一反射镜54与第二反射镜55对称设置，能将光线参考臂偏转，从而减少占用空间，所述第二准直镜52与第二光纤耦合器6对应设置，参考臂光线依次经过第一准直镜51、色散补偿器53、第一反射镜54、第二反射镜55后由第二准直镜52接收至第二光纤耦合器6。The reference arm 5 includes a first collimating mirror 51, a dispersion compensator 53, a first reflecting mirror 54, a second reflecting mirror 55, and a second collimating mirror 52 arranged in sequence. An optical fiber coupler 3 is correspondingly arranged, which can receive the light of the reference arm and project it. The light of the reference arm projected by the first collimating mirror 51 is compensated by the dispersion compensator 53 to compensate the optical path of the lens in the corresponding sample arm area. The first reflecting mirror 54 and the second reflecting mirror 55 are symmetrically arranged, which can deflect the light reference arm, thereby reducing the space occupied. The first collimating mirror 51 , the dispersion compensator 53 , the first reflecting mirror 54 and the second reflecting mirror 55 are then received by the second collimating mirror 52 to the second fiber coupler 6 .
所述第二光纤耦合器6用于光程差匹配，其根据长度需求和参考臂反射光强度需要进行选择，实现样品臂和参考臂的光程差匹配。The second optical fiber coupler 6 is used for optical path difference matching, which is selected according to the length requirement and the reflected light intensity of the reference arm, so as to realize the optical path difference matching between the sample arm and the reference arm.
进一步的，所述第二光纤耦合器6连接有偏振控制器9，调整光线的偏振性质。Further, the second fiber coupler 6 is connected with a polarization controller 9 to adjust the polarization properties of the light.
所述第三光纤耦合器7与第一光纤耦合器3和第二光纤耦合器6对应设置，可以接收样品臂光线的反射光与参考臂光线，在此，样品臂光线的反射光与参考臂光线能相干涉，第三光纤耦合器7宜选择50:50的分光效能规格。The third fiber coupler 7 is arranged corresponding to the first fiber coupler 3 and the second fiber coupler 6, and can receive the reflected light of the sample arm light and the reference arm light. Here, the reflected light of the sample arm light and the reference arm light The light can interfere with each other, and the third fiber coupler 7 should choose the spectroscopic efficiency specification of 50:50.
所述平衡探测器8连接第三光纤耦合器7与控制中心1，能提取信号并发送至控制中心1，所述平衡探测器8能通过两个光学输入信号相减消除共模噪声，从干扰噪声本底中提取时减小光信号路径中的变化并通过控制中心1进行后续信号处理分析。The balanced detector 8 is connected to the third fiber coupler 7 and the control center 1, and can extract the signal and send it to the control center 1. The balanced detector 8 can eliminate the common mode noise by subtracting the two optical input signals to avoid interference. When extracting from the noise floor, the variation in the optical signal path is reduced and the subsequent signal processing analysis is performed by the control center 1.
上述适用于房角流出通道Schlemm’s管全周动态测定的OCT成像***的成像过程如下：光源2射出光线，光线经第一光纤耦合器3后一分为二，其中一束为样品臂光线，样品臂光线依次经过第三准直镜41、第一扫描振镜42、第一透镜43、第二透镜44、第二扫描振镜45、第三透镜46后进入人眼，形成反射光按原路返回至第一光纤耦合器3后进入第三光纤耦合器7，另一束为参考臂光线，参考臂光线依次经过第一准直镜51、色散补偿器53、第一反射镜54、第二反射镜55、第二准直镜52、第二光纤耦合器6后进入第三光纤耦合器7，在此，样品臂光线的反射光与参考臂光线想干涉，随后平衡探测器8通过两个光学输入信号相减消除共模噪声，从干扰噪声本底中提取时减小光信号路径中的变化并通过控制中心1进行后续信号处理分析。The imaging process of the above-mentioned OCT imaging system suitable for the full circumference dynamic measurement of the Schlemm's tube of the angle outflow channel is as follows: the light source 2 emits light, and the light is divided into two after passing through the first fiber coupler 3, one of which is the sample arm light, and the sample The arm light enters the human eye after passing through the third collimating mirror 41, the first scanning galvanometer 42, the first lens 43, the second lens 44, the second scanning galvanometer 45, and the third lens 46 in turn, forming the reflected light according to the original path. After returning to the first fiber coupler 3 and entering the third fiber coupler 7, the other beam is the reference arm light, and the reference arm light passes through the first collimating mirror 51, the dispersion compensator 53, the first reflecting mirror 54, the second The mirror 55, the second collimating mirror 52, and the second fiber coupler 6 then enter the third fiber coupler 7, where the reflected light of the sample arm light and the reference arm light interfere, and then the balance detector 8 passes through the two Optical input signal subtraction eliminates common-mode noise, reduces changes in the optical signal path when extracted from the interference noise floor, and conducts subsequent signal processing and analysis through control center 1.
采用上述方案，利用透射式的参考臂结构，无需使用环形器，从而避免了环形器的窄宽带限制，最大限度地保留轴向分辨率，从而实现Schlemm’s管的观察和测量。With the above scheme, the use of the transmissive reference arm structure eliminates the need to use a circulator, thereby avoiding the narrow bandwidth limitation of the circulator and maximizing the preservation of the axial resolution, thereby realizing the observation and measurement of Schlemm’s tube.
在本发明的描述中，需要说明的是，术语“中心”、“纵向”、“横向”、“上”、“下”、“前”、“后”、“左”、“右”、“竖直”、“水平”、“顶”、“底”“内”、“外”等指示的方位或位置关系为基于附图所示的方位或位置关系，仅是为了便于描述本发明和简化描述，而不是指示或暗示所指的装置或元件必须具有特定的方位、以特定的方位构造和操作，因此不能理解为对本发明的限制。此外，术语“第一”、“第二”仅用于描述目的，而不能理解为指示或暗示相对重要性。In the description of the present invention, it should be noted that the terms "center", "portrait", "horizontal", "top", "bottom", "front", "rear", "left", "right", " The orientations or positional relationships indicated by vertical, horizontal, top, bottom, inside, and outside are based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying It is described, rather than indicated or implied, that the device or element referred to must have a particular orientation, be constructed and operate in a particular orientation, and therefore should not be construed as limiting the invention. Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed to indicate or imply relative importance.
在本发明的描述中，需要说明的是，除非另有明确的规定和限定，术语“安装”、“相连”、“连接”应做广义理解，例如，可以是固定连接，也可以是可拆卸连接，或一体地连接；可以是机械连接，也可以是电连接；可以是直接相连，也可以通过中间媒介间接相连，可以是两个元件内部的连通。对于本领域的普通技术人员而言，可以具体情况理解上述术语在本发明中的具体含义。此外，在本发明的描述中，除非另有说明，“多个”的含义是两个或两个以上。In the description of the present invention, it should be noted that the terms "installed", "connected" and "connected" should be understood in a broad sense, unless otherwise expressly specified and limited, for example, it may be a fixed connection or a detachable connection Connection, or integral connection; can be mechanical connection, can also be electrical connection; can be directly connected, can also be indirectly connected through an intermediate medium, can be internal communication between two elements. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood in specific situations. Also, in the description of the present invention, unless otherwise specified, "plurality" means two or more.
各位技术人员须知：虽然本发明已按照上述具体实施方式做了描述，但是本发明的发明思想并不仅限于此发明，任何运用本发明思想的改装，都将纳入本专利专利权保护范围内。 Note to all technicians: Although the present invention has been described according to the above-mentioned specific embodiments, the inventive idea of the present invention is not limited to this invention, and any modification using the idea of the present invention will be included in the protection scope of this patent right.

Claims (7)

  1. 一种适用于房角流出通道Schlemm’s管全周动态测定的OCT成像***，其特征在于：包括控制中心（1）、光源（2）、第一光纤耦合器（3）、样品臂（4）、参考臂（5）、第二光纤耦合器（6）、第三光纤耦合器（7）、平衡探测器（8）；An OCT imaging system suitable for full-circumference dynamic determination of Schlemm's tube in an angle outflow channel, characterized in that it comprises a control center (1), a light source (2), a first optical fiber coupler (3), a sample arm (4), a reference arm (5), a second fiber coupler (6), a third fiber coupler (7), and a balanced detector (8);
    所述光源（2）用于输出光线；The light source (2) is used for outputting light;
    所述第一光纤耦合器（3）与光源（2）对应设置，光线经第一光纤耦合器（3）后分为样品臂光线与参考臂光线，样品臂光线进入样品臂（4），参考臂光线进入参考臂（5）；The first optical fiber coupler (3) is arranged corresponding to the light source (2), the light is divided into the sample arm light and the reference arm light after passing through the first optical fiber coupler (3), the sample arm light enters the sample arm (4), the reference arm light The arm ray enters the reference arm (5);
    所述第二光纤耦合器（6）与参考臂（5）对应设置，参考臂光线经过参考臂（5）后输送至第二光纤耦合器（6）；The second optical fiber coupler (6) is arranged corresponding to the reference arm (5), and the light of the reference arm is transmitted to the second optical fiber coupler (6) after passing through the reference arm (5);
    所述第三光纤耦合器（7）与第一光纤耦合器（3）和第二光纤耦合器（6）对应设置，样品臂光线的反射光与参考臂光线能在第三光纤耦合器（7）中相干涉；The third fiber coupler (7) is arranged corresponding to the first fiber coupler (3) and the second fiber coupler (6), and the reflected light of the sample arm light and the reference arm light can be connected to the third fiber coupler (7). ) in phase interference;
    所述平衡探测器（8）连接第三光纤耦合器（7）与控制中心（1），能提取信号并发送至控制中心（1）。The balanced detector (8) is connected with the third fiber coupler (7) and the control center (1), and can extract signals and send them to the control center (1).
  2. 根据权利要求1所述的适用于房角流出通道Schlemm’s管全周动态测定的OCT成像***，其特征在于：所述光源（2）为中心波长为1060nm、宽带100nm的扫频源光源，扫描速度为200kHz，所述光源（2）与控制中心（1）连接。The OCT imaging system suitable for full-circumference dynamic determination of Schlemm's tube in the angle outflow channel according to claim 1, characterized in that: the light source (2) is a swept frequency source light source with a center wavelength of 1060 nm and a broadband of 100 nm, and the scanning speed is At 200kHz, the light source (2) is connected to the control center (1).
  3. 根据权利要求1所述的适用于房角流出通道Schlemm’s管全周动态测定的OCT成像***，其特征在于：所述参考臂（5）包括第一准直镜（51）、第二准直镜（52），第一准直镜（51）与第一光纤耦合器（3）对应设置，第二准直镜（52）与第二光纤耦合器（6）对应设置，参考臂光线经第一准直镜（51）投出后由第二准直镜（52）接收至第二光纤耦合器（6）中。The OCT imaging system suitable for full-circumference dynamic determination of Schlemm's tube in the angle outflow channel according to claim 1, characterized in that: the reference arm (5) comprises a first collimating mirror (51) and a second collimating mirror (52), the first collimating mirror (51) is arranged corresponding to the first optical fiber coupler (3), the second collimating mirror (52) is arranged correspondingly to the second optical fiber coupler (6), and the light of the reference arm passes through the first optical fiber coupler (6). After the collimating mirror (51) is projected, it is received by the second collimating mirror (52) into the second optical fiber coupler (6).
  4. 根据权利要求3所述的适用于房角流出通道Schlemm’s管全周动态测定的OCT成像***，其特征在于：所述参考臂（5）还包括色散补偿器（53）。The OCT imaging system suitable for full-circumference dynamic determination of Schlemm's tube of the angle outflow channel according to claim 3, characterized in that: the reference arm (5) further comprises a dispersion compensator (53).
  5. 根据权利要求3或4所述的适用于房角流出通道Schlemm’s管全周动态测定的OCT成像***，其特征在于：所述参考臂（5）还包括第一反射镜（54）、第二反射镜（55），所述第一反射镜（54）与第二反射镜（55）对称设置。The OCT imaging system suitable for the full circumference dynamic measurement of the Schlemm's tube of the angle outflow channel according to claim 3 or 4, characterized in that: the reference arm (5) further comprises a first reflection mirror (54), a second reflection mirror A mirror (55), the first reflecting mirror (54) and the second reflecting mirror (55) are symmetrically arranged.
  6. 根据权利要求3所述的适用于房角流出通道Schlemm’s管全周动态测定的OCT成像***，其特征在于：所述第二光纤耦合器（6）连接有偏振控制器（9）。The OCT imaging system suitable for full-circumference dynamic measurement of the Schlemm's tube of the angle outflow channel according to claim 3, characterized in that: the second fiber coupler (6) is connected with a polarization controller (9).
  7. 根据权利要求1所述的适用于房角流出通道Schlemm’s管全周动态测定的OCT成像***，其特征在于：所述样品臂（4）包括第三准直镜（41）、第一扫描振镜（42）、第一透镜（43）、第二透镜（44）、第二扫描振镜（45）、第三透镜（46），样品臂光线依次经过第三准直镜（41）、第一扫描振镜（42）、第一透镜（43）、第二透镜（44）、第二扫描振镜（45）、第三透镜（46）后进入人眼进行反射。The OCT imaging system suitable for the full circumference dynamic measurement of the Schlemm's tube of the angle outflow channel according to claim 1, characterized in that: the sample arm (4) comprises a third collimating mirror (41), a first scanning galvanometer (42), a first lens (43), a second lens (44), a second scanning galvanometer (45), and a third lens (46), the sample arm light passes through the third collimating lens (41), the first The scanning galvanometer (42), the first lens (43), the second lens (44), the second scanning galvanometer (45), and the third lens (46) enter the human eye for reflection.
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