WO2021149864A1 - Electric field-based cancer treatment apparatus - Google Patents
Electric field-based cancer treatment apparatus Download PDFInfo
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- WO2021149864A1 WO2021149864A1 PCT/KR2020/002967 KR2020002967W WO2021149864A1 WO 2021149864 A1 WO2021149864 A1 WO 2021149864A1 KR 2020002967 W KR2020002967 W KR 2020002967W WO 2021149864 A1 WO2021149864 A1 WO 2021149864A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
- A61N1/403—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals for thermotherapy, e.g. hyperthermia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36002—Cancer treatment, e.g. tumour
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
Definitions
- the present application relates to an electric field-based cancer treatment device, and more particularly, by generating an alternating current near the human body and the resulting magnetic flux change generates an induced electromotive force in the human body, the skin current per unit area is maintained below a certain level while maintaining the
- the present invention relates to an electric field-based cancer treatment device that can maximize the electric field and deliver a high-intensity electric field to a tumor located deep inside the patient's body, thereby increasing the cancer treatment effect and lowering the skin current that causes side effects such as skin burns.
- the first strength of electric field therapy is that it is known that the electric field has a great effect only on dividing cells, so it will intensively affect cancer cells that divide faster than normal cells, and the side effects are expected to be very minimal compared to existing treatments. The point is that it becomes (refer to Prior Document 2).
- Prior Document 3 side effects of electric field treatment were significantly lower in 7 items out of a total of 9 comparison items of side effects between chemotherapy and electric field treatment, and in two items, chemotherapy and electric field treatment showed almost the same level of side effects.
- the third strength is that when the electric field is applied extensively, including the treatment area, it is expected that it will have a therapeutic effect even on very fine tumors that are not visible on medical images such as CT.
- an electric field is applied around the tumor, an electric field that cannot be ignored is transmitted not only to the tumor but also to the tumor area. Therefore, it is expected that the probability of cancer metastasis can also be dramatically reduced (refer to Prior Literature 5).
- the current electric field cancer treatment method was approved by the US FDA for recurrent glioblastoma cancer in 2011 and for the first diagnosed glioblastoma in 2015. In Japan, it has been approved for treatment of patients with recurrent glioblastoma. In addition, the number of treated patients is increasing rapidly every year, showing a 50-fold increase from 152 in 2014 to 8813 in 2018 (refer to Prior Document 6).
- the currently commercialized electric field cancer treatment system has been developed so that it can be treated only with an electric field with a weak intensity of about 1 to 3 V/cm, and in order to secure the maximum possible therapeutic effect with this weak electric field, the patient's sleep time is reduced. Except for, there is the inconvenience of having to receive treatment almost all day (18-24 hours/day)
- the maximum limit current per unit area is 100 mA/cm 2 or less, but the recommended limit current per unit area recommended for electric field treatment is 30 mA/cm 2 or less (refer to Prior Document 7). Therefore, in order to maximize the therapeutic effect, a method is needed to increase the size of the electric field delivered to the body while maintaining the current flowing through the skin below the recommended limit current.
- an embodiment of the present invention provides an electric field-based cancer treatment apparatus.
- the electric field-based cancer treatment device is made in a coil shape to surround the affected part of the patient and includes a coiled conductor to which an alternating current is applied, and induction induced through a change in magnetic flux made by the coiled conductor to which the alternating current is applied. It is characterized in that the electromotive force is applied to the body of the patient.
- the alternating current is characterized in that it has a frequency band in the range of 10 kHz to 300 kHz.
- the coil-type conductor is characterized in that it has a geometric structure to surround the affected part of the patient by the internal space.
- it characterized in that it further comprises one or more conductive media provided between the coil-type conductor and the patient.
- the conductive medium is manufactured in a fixed form to fill a space between the first medium and the coiled conductor, and a first medium manufactured to be customized to the patient to be in contact with or adjacent to the skin of the patient. It is characterized in that it includes a second medium.
- the conductive medium is characterized in that the electrical conductivity is 0.1 S/m or more.
- the conductive medium is characterized in that the relative permeability (Relative permeability) is 2 or more.
- the electric field-based cancer treatment device is a wearable device in which the conductive medium is attached to the body of the patient.
- an alternating current is generated near the human body, and the resulting change in magnetic flux generates an induced electromotive force in the human body, so that the skin current per unit area is It is possible to maximize only the electric field inside the human body while maintaining it below a certain level. Therefore, compared to the prior art, by delivering an electric field of high intensity to a tumor located deep within the patient's body, the cancer treatment effect can be increased, and the skin current that causes side effects such as skin burns can be lowered.
- 1 is a diagram illustrating a difference in treatment effect according to an electric field strength and an electric field application time during electric field treatment.
- FIG. 2 is a schematic diagram of an electric field-based cancer treatment apparatus according to an embodiment of the present invention.
- FIG. 3 is a diagram showing the results of calculating the magnitude and current density of an induced electric field applied to the inside of the head and neck phantom after positioning the head and neck phantom in the solenoid in the electric field-based cancer treatment apparatus according to an embodiment of the present invention.
- FIG. 4 is a diagram showing the results of calculating the magnitude and current density of an induced electric field applied to the inside of the head and neck phantom by placing the conductive medium and the head and neck phantom together in the solenoid in the electric field-based cancer treatment device according to another embodiment of the present invention. .
- FIG. 5 is a diagram illustrating the distribution and magnitude of the induced electric field applied to the XY, XZ and YZ planes at the center of the head and neck phantom in the embodiment of the present invention shown in FIG. 4 .
- FIG. 6 is a view showing the distribution and magnitude of the induced electric field applied to the XY, XZ and YZ planes at the center of the head and neck phantom while changing the magnitude of the current in the embodiment of the present invention shown in FIG. 4 .
- FIG. 7 is a diagram illustrating the results of calculating the average electric field delivered to the head and neck phantom and the average current density flowing through the skin while changing the magnitude of the current in the embodiment of the present invention shown in FIG. 4 .
- FIG. 8 shows the induced electric field applied to the XY, XZ and YZ planes from the center of the head and neck phantom while maintaining the same magnitude of current and changing the number of turns per unit length of the solenoid in the embodiment of the present invention shown in FIG. It is a diagram showing the distribution and size.
- FIG. 9 shows the average electric field delivered to the head and neck phantom and the average current density flowing through the skin while maintaining the same magnitude of current and changing the number of turns per unit length of the solenoid in the embodiment of the present invention shown in FIG. 4 . It is a diagram showing one result.
- FIG. 10 is a view showing the result of calculating the average magnitude of the induced electric field applied to the inside of the head and neck phantom while changing the conductivity of the conductive medium in the embodiment of the present invention shown in FIG. 4 .
- FIG. 11 is a view showing the result of calculating the average magnitude of the induced electric field applied to the inside of the head and neck phantom while changing the relative permeability of the conductive medium in the embodiment of the present invention shown in FIG. 4 .
- FIG. 12 is a diagram illustrating an example in which a conductive medium positioned inside a solenoid is separated into two regions according to another embodiment of the present invention.
- FIG. 2 is a schematic diagram of an electric field-based cancer treatment apparatus according to an embodiment of the present invention.
- the electric field-based cancer treatment apparatus 100 is formed in a coil shape to surround the affected part of the patient 10 and a coil-type conductor 110 to which an alternating current is applied. may be included, and an induced electromotive force induced through a magnetic flux change made by the coiled conductor 110 to which an alternating current is applied may be applied to the body of the patient 10 .
- the alternating current applied to the coiled conductor 110 may have a frequency band in the range of 10 kHz to 300 kHz.
- the coiled conductor 110 may have a geometric structure to surround the affected part of the patient 10 by the internal space, and a plurality of coiled conductors 110 may be connected in an array form.
- the coil-type conductor 110 is exemplified as a cylindrical solenoid, but the present invention is not necessarily limited thereto, and the coil-type conductor 110 is a cuboid, a triangular prism, etc., the affected part of the patient 10 . It can be formed in various types of geometric structures that can apply the maximum induced electromotive force to the
- the coil-type conducting wire 110 may be replaced with another type of electric field generating means (eg, an alternating current electric circuit, an electromagnet, etc.).
- another type of electric field generating means eg, an alternating current electric circuit, an electromagnet, etc.
- the present invention breaks away from the existing electric field cancer treatment method that uses at least one pair of electrodes to apply an electric field to the human body, so that an alternating current flows inside a conducting wire (eg, a coil-type conducting wire).
- a conducting wire eg, a coil-type conducting wire.
- the electric field-based cancer treatment apparatus 100 minimizes side effects that occur when an electrode attached to the skin is used by using the same principle, and at the same time adjusts the intensity of an alternating current applied to the body.
- the electric field size can be adjusted.
- one or more conductive media 120 provided between the coiled conductor 110 and the patient 10 may be further included, and the conductive media 120 is the patient 10 . It plays a role in increasing the strength of the electric field in the body.
- the conductive medium 120 is a three-dimensional structure, and may refer not only to a medium composed of components similar to in vivo tissues, but also to a member having conductivity through which current can flow.
- the conductive medium 120 may have an electrical conductivity of 0.1 S/m or more, and a relative permeability of 2 or more.
- the electric field-based cancer treatment apparatus 100 described above with reference to FIG. 2 may be implemented as a wearable device in which the conductive medium 120 is attached to the patient's body 10 .
- FIG. 3 is a view showing the results of calculating the magnitude and current density of an induced electric field applied to the inside of the head and neck phantom by positioning the head and neck phantom in the solenoid in the electric field-based cancer treatment device according to an embodiment of the present invention, specifically 1 cm
- the simulation results of the induced electric field (Field Intensity) and current density (Current Density) applied depending on the position when an alternating current of 1A is applied to a cylindrical solenoid with a diameter of 20 cm with 25 turns of the conductor is shown.
- the head and neck phantom used is manufactured so that the physical size and electrical characteristics are similar to those of the human body.
- FIG. 4 is an electric field-based cancer treatment device according to another embodiment of the present invention, in which a conductive medium and a head and neck phantom are placed together in a solenoid, and the magnitude and current density of the induced electric field applied to the inside of the head and neck phantom are calculated.
- a cylindrical conductive medium and a head and neck phantom are placed together in the inner space of a cylindrical solenoid with a diameter of 100 cm in which a wire is wound 25 times per 1 cm, and an alternating current of 1A is applied to the cylindrical solenoid, the magnitude of the induced electric field applied according to the position
- the simulation results of the current density are shown.
- FIG. 5 is a diagram illustrating the distribution and magnitude of the induced electric field applied to the XY, XZ and YZ planes at the center of the head and neck phantom in the embodiment of the present invention shown in FIG. 4 .
- the inner space of the cylindrical solenoid is sufficiently large, and the greater the electric field is applied as the position of the head and neck phantom is farther from the inner center of the cylindrical solenoid. Due to these characteristics, in the embodiment of the present invention, the head and neck phantom or the affected part of the patient is preferably located at a point more than a preset distance from the center of the cylindrical solenoid.
- the magnitude of the electric field applied to the center of the head and neck phantom is also about 4 V/cm, which increases the electric field by about 2 times or more compared to the method using the conventional electrode. know that it can be done.
- the skin current density is about 6 mA/cm 2 or less, which is less than the recommended limit current of 30 mA/cm 2 , so that side effects due to the current are minimized.
- FIG. 6 is a view showing the distribution and magnitude of the induced electric field applied to the XY, XZ and YZ planes at the center of the head and neck phantom while changing the magnitude of the current in the embodiment of the present invention shown in FIG.
- the distribution of the electric field applied to the inside of the head and neck phantom is shown when the magnitude of the alternating current is changed to 1A, 2A, and 3A.
- FIG. 7 is a view showing the results of calculating the average electric field delivered to the head and neck phantom and the average current density flowing through the skin while changing the magnitude of the current in the embodiment of the present invention shown in FIG. 4 .
- FIG. The results of calculating the average value of the magnitude of the electric field distributed inside the head and neck phantom and the average value of the current density applied to the surface are shown when the magnitude of the applied AC current is changed to 1A, 2A, 3A, and 4A.
- FIG. 8 shows induction applied to the XY, XZ and YZ planes at the center of the head and neck phantom while maintaining the same magnitude of current and changing the number of turns per unit length of the solenoid in the embodiment of the present invention shown in FIG.
- This is a diagram showing the distribution and magnitude of the electric field. Specifically, when the magnitude of the alternating current is kept constant at 1A and the number of turns of the conductor per cm is changed to 25, 50, and 75, the electric field applied inside the head and neck phantom The distribution is shown.
- FIG. 9 shows the size of the average electric field delivered to the head and neck phantom and the average current density flowing through the skin while maintaining the same current magnitude and changing the number of turns per unit length of the solenoid in the embodiment of the present invention shown in FIG.
- This is a diagram showing the result of calculating . Specifically, distribution inside the head and neck phantom when the size of the alternating current is kept constant at 1A and the number of turns per cm of the conductor is changed to 25, 50, 75, and 100 times. The results of calculating the average value of the magnitude of the electric field and the average value of the current density applied to the surface are shown.
- FIG. 10 is a view showing the result of calculating the average magnitude of the induced electric field applied to the inside of the head and neck phantom while changing the conductivity of the conductive medium in the embodiment of the present invention shown in FIG. It is a diagram showing the result of calculating the average magnitude of the induced electric field applied to the inside of the head and neck phantom while changing the relative permeability of the conductive medium in the embodiment of the present invention.
- the electric field synergistic effect in the head and neck phantom occurs when the electrical conductivity and the relative permeability of the conductive medium are respectively greater than a certain size. Specifically, when the electrical conductivity is 0.1 S/m or more, and the relative permeability is 2 or more, there is an electric field synergistic effect, and in particular, when the electrical conductivity is in the range of 6 S/m to 20 S/m, the largest electric field synergistic effect is shown. Able to know.
- FIG. 12 is a diagram illustrating an example in which a conductive medium positioned inside a solenoid is separated into two regions according to another embodiment of the present invention.
- the conductive medium 120 is a first medium (that is, the patient-customized medium (Customized Conducting Medium)) 121 manufactured to be in contact with or adjacent to the skin of the patient 10, and,
- the second medium (ie, fixed shape of medium) 122 manufactured in a fixed shape to fill the space between the first medium 121 and the coiled conductor 110 may be implemented separately. there is.
- the first medium 121 in direct contact with or adjacent to the patient 10 is customized for each patient, and the second medium 122 can be used in common for a plurality of patients, so that the electric field more efficiently It is possible to implement a cancer-based treatment device.
- the electric field-based cancer treatment apparatus may be implemented in such a way that, for example, a patient enters the inside of a cylindrical electric field generator to receive treatment, and according to the above-described embodiment, a high electric field can be applied to the body. Unlike conventional methods based on electrodes, high-electric field treatment is possible for a short period of time, and thus a better electric field treatment effect can be achieved.
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Abstract
An electric field-based cancer treatment apparatus according to one embodiment of the present invention comprises a coil-type leading wire which is formed as a coil type so as to encompass the affected part of a patient, and to which alternating current is applied, and applies, to the inside of the body of the patient, an induced electromotive force induced through a magnetic flux change made by means of the coil-type leading wire to which the alternating current is applied.
Description
본 출원은 전기장 기반 암치료 장치에 관한 것으로, 보다 상세하게는 인체 근처에서 교류 전류를 발생시키고 그로 인한 자속변화가 인체 내에 유도기전력을 발생시킴으로써 단위면적당 피부 전류는 일정 수준 이하로 유지하면서도 인체 내부의 전기장만을 극대화하여, 높은 세기의 전기장을 환자 체내의 심부에 위치한 종양에 전달함으로써 암치료 효과는 증대시킬 수 있으면서도 피부 화상 등의 부작용을 일으키는 피부 전류를 낮출 수 있는 전기장 기반 암치료 장치에 관한 것이다.The present application relates to an electric field-based cancer treatment device, and more particularly, by generating an alternating current near the human body and the resulting magnetic flux change generates an induced electromotive force in the human body, the skin current per unit area is maintained below a certain level while maintaining the The present invention relates to an electric field-based cancer treatment device that can maximize the electric field and deliver a high-intensity electric field to a tumor located deep inside the patient's body, thereby increasing the cancer treatment effect and lowering the skin current that causes side effects such as skin burns.
2000년대 초, 이스라엘 생물리학 교수인 Yoram Palti는 분열하는 암세포에 교류전기장을 걸어주면 분열이 지연되거나 사멸하는 현상을 처음으로 발견했으며, 2004년에는 Cancer Research 저널에 세계 최초로 전기장 암치료 효과에 대한 연구결과를 발표하였다(선행문헌 1 참조). 그 후 전기장 암치료에 대한 여러 연구논문들이 발표되었으며 암치료 학계에서는 전기장 치료의 3가지 강점으로 인해 큰 주목을 하고 있다. In the early 2000s, Israeli biophysics professor Yoram Palti discovered for the first time the phenomenon that division or death was delayed when an alternating electric field was applied to dividing cancer cells. In 2004, the world's first study on the effect of electric field cancer treatment was published in the Journal of Cancer Research. The results were published (see Prior Document 1). After that, several research papers on electric field cancer treatment were published, and the cancer treatment academia is receiving great attention due to the three strengths of electric field treatment.
전기장 치료의 첫 번째 강점은 전기장은 분열하는 세포에만 큰 영향을 미치는 것으로 알려져 있기 때문에 정상세포에 비해 분열속도가 빠른 암세포에 집중적으로 영향을 미치게 되고, 부작용도 기존 치료법과 비교했을 때 매우 미미할 것으로 예상된다는 점이다(선행문헌 2 참조). 실제로 2013년에 발표된 논문(선행문헌 3 참조)에 의하면 항암치료와 전기장치료의 부작용 비교 항목 총 9개 중 7개의 항목에서 전기장 치료의 부작용이 월등히 낮게 나타났으며, 2개의 항목에 대해서는 항암치료와 전기장 치료가 거의 동등한 수준의 부작용을 보였다.The first strength of electric field therapy is that it is known that the electric field has a great effect only on dividing cells, so it will intensively affect cancer cells that divide faster than normal cells, and the side effects are expected to be very minimal compared to existing treatments. The point is that it becomes (refer to Prior Document 2). In fact, according to a paper published in 2013 (see Prior Literature 3), side effects of electric field treatment were significantly lower in 7 items out of a total of 9 comparison items of side effects between chemotherapy and electric field treatment, and in two items, chemotherapy and electric field treatment showed almost the same level of side effects.
두 번째로, 전기장을 이용한 암치료는 아직 초기 단계임에도 불구하고 치료효능 측면에서 기존의 치료법에 비해 더 좋은 결과를 보여주고 있다. 그 예로, 난치암 중 하나인 악성 교모세포종(glioblastoma multiforme, GBM) 환자가 항암치료만 받은 경우 Progression Free Survival(PFS)과 Overall Survival(OS) 및 2년 이상 생존확률이 각각 4.0개월, 16.0개월, 31%로 나타난 반면, 전기장 치료가 추가된 경우에는 6.7개월, 20.9개월, 43%로 나타나, 기존 치료법에 비해 약 1.7, 1.3, 1.4배 더 좋은 결과를 보여주었다(선행문헌 4). Second, although cancer treatment using electric fields is still in its infancy, it shows better results than conventional treatments in terms of therapeutic efficacy. For example, if a patient with glioblastoma multiforme (GBM), one of the intractable cancers, received only chemotherapy, the Progression Free Survival (PFS) and Overall Survival (OS) and survival rates of more than 2 years were 4.0 months, 16.0 months, and 16.0 months, respectively. On the other hand, when the electric field treatment was added, the results were 6.7 months, 20.9 months, and 43%, showing approximately 1.7, 1.3, and 1.4 times better results than the conventional treatment (Prior Literature 4).
마지막으로 세 번째 강점은 전기장이 치료부위를 포함하여 광범위하게 적용될 경우 CT 등의 의료영상에서 보이지 않는 매우 미세한 종양에 대해서도 치료 효과가 있을 것으로 기대된다는 점이다. 종양을 중심으로 전기장을 걸어주게 되면 종양뿐만 아니라 종양주변에도 무시할 수 없는 전기장이 전달되기 때문에, 종양주변에 존재하나 육안으로 확인 불가능할 정도의 미세한 크기의 종양에도 전기장이 영향을 미쳐 암세포의 분열을 억제시킬 수 있으며 이에 따라 암 전이 확률도 획기적으로 낮출 수 있을 것으로 기대된다(선행문헌 5 참조). Lastly, the third strength is that when the electric field is applied extensively, including the treatment area, it is expected that it will have a therapeutic effect even on very fine tumors that are not visible on medical images such as CT. When an electric field is applied around the tumor, an electric field that cannot be ignored is transmitted not only to the tumor but also to the tumor area. Therefore, it is expected that the probability of cancer metastasis can also be dramatically reduced (refer to Prior Literature 5).
현재 전기장 암치료법은 2011년 재발한 교모세포종 암에 대해, 2015년에는 최초 진단된 교모세포종에 대해 미국 FDA 승인을 받았으며, 유럽에서는 CE 마크를 획득하여 미국, 독일, 스위스 등지에서 약 1000 여개의 병원을 통해 시행되고 있으며, 일본에서도 재발한 교모세포종 환자에 대하여 치료 허가를 받은 상태이다. 또한 치료 받은 환자 수는 매년 급격히 증가하고 있어 2014년에 152명에서 2018년에는 8813명으로 50배 이상의 증가율을 보여주고 있다(선행문헌 6 참조). The current electric field cancer treatment method was approved by the US FDA for recurrent glioblastoma cancer in 2011 and for the first diagnosed glioblastoma in 2015. In Japan, it has been approved for treatment of patients with recurrent glioblastoma. In addition, the number of treated patients is increasing rapidly every year, showing a 50-fold increase from 152 in 2014 to 8813 in 2018 (refer to Prior Document 6).
하지만 현재의 전기장 암치료는 치료효과를 극대화하기 위해 몇 가지 해결해야 할 과제가 있다. However, the current electric field cancer treatment has several challenges to be solved in order to maximize the therapeutic effect.
현재까지의 연구 결과에 따르면, 전기장 세기 및 전기장 인가 시간에 따라 암 종별 전기장 치료의 효과는 차이를 나타내며, 전기장 세기 및 인가 시간이 크면 클수록 암세포에 대한 사멸 및 분열억제 효과가 크다(선행문헌 7 및 도 1 참조). 따라서, 원하는 치료 효과를 달성하기 위해서는 충분한 크기의 전기장 세기가 필수적이다.According to the research results so far, the effect of electric field treatment for each cancer type is different depending on the electric field strength and the electric field application time, and the greater the electric field strength and application time, the greater the apoptosis and anti-mitotic effect on cancer cells (Prior Document 7 and see Fig. 1). Therefore, in order to achieve a desired therapeutic effect, an electric field strength of sufficient magnitude is essential.
현재 상용화된 전기장 암치료 시스템은 1 내지 3 V/cm 정도의 약한 세기의 전기장으로만 치료가 가능하도록 개발되었으며, 이처럼 약한 세기의 전기장으로 가능한 한 최대의 치료효과를 확보하기 위해서는 환자의 수면시간을 제외하고 거의 하루 종일(18-24시간/일) 치료를 받아야 하는 불편함이 있다. The currently commercialized electric field cancer treatment system has been developed so that it can be treated only with an electric field with a weak intensity of about 1 to 3 V/cm, and in order to secure the maximum possible therapeutic effect with this weak electric field, the patient's sleep time is reduced. Except for, there is the inconvenience of having to receive treatment almost all day (18-24 hours/day)
또한, 일일 치료시간을 늘리는 것은 이미 한계에 도달했으며 이러한 경우 치료효과를 확보하기 위해서는 충분한 크기의 전기장을 인가하는 것이 필수불가결한 요소라고 할 수 있다. 단순히 인가된 전압의 크기를 증가시켜서 체내에 전달되는 전기장의 크기를 증가시키는 것은 물리적으로는 가능하다. 그러나, 이러한 전기장의 상승은 피부에 부착된 전극에 의해 피부로 흐르는 전류도 함께 증가시키기 때문에 화상과 같은 심각한 부작용을 야기시킬 수 있다. 이러한 이유 때문에 피부에 전달되는 한계전류가 전기장 치료에서 중요한 요소가 되며 현재의 전기장 암치료에서는 피부에 부작용이 생기지 않는 범위 내에서 가능한 최대의 전기장을 인체에 인가하고 있지만 그 크기는 만족할 만한 수준이 아니다(선행문헌 7 참조).In addition, increasing the daily treatment time has already reached its limit, and in this case, it is essential to apply an electric field of sufficient magnitude to secure the therapeutic effect. It is physically possible to increase the magnitude of the electric field delivered to the body by simply increasing the magnitude of the applied voltage. However, since the increase of the electric field also increases the current flowing to the skin by the electrode attached to the skin, it may cause serious side effects such as burns. For this reason, the limiting current delivered to the skin becomes an important factor in electric field therapy, and in current electric field cancer treatment, the maximum possible electric field is applied to the human body within the range that does not cause side effects on the skin, but the size is not satisfactory. (See Prior Document 7).
일반적으로 단위면적당 최대한계전류는 100mA/cm2 이하이지만 전기장 치료에서 권고되는 단위면적당 권고한계전류는 30mA/cm2 이하라고 할 수 있다(선행문헌 7 참조). 따라서, 치료효과를 극대화시키기 위해서는 피부에 흐르는 전류는 권고한계전류 이하로 유지하면서 체내에 전달되는 전기장의 크기는 증가시킬 수 있는 방법이 필요하다.In general, the maximum limit current per unit area is 100 mA/cm 2 or less, but the recommended limit current per unit area recommended for electric field treatment is 30 mA/cm 2 or less (refer to Prior Document 7). Therefore, in order to maximize the therapeutic effect, a method is needed to increase the size of the electric field delivered to the body while maintaining the current flowing through the skin below the recommended limit current.
선행문헌 1: Eilon D. Kirson et al, disruption of cancer cell replication by alternating electric fields, cancer research, 64, 3288-3295 (2004)Prior Document 1: Eilon D. Kirson et al, disruption of cancer cell replication by alternating electric fields, cancer research, 64, 3288-3295 (2004)
선행문헌 2: Miklos Pless, Uri Weinberg, tumor treating fields: concept, evidence, future, Expert Opinion, 20(8), 1099-1106 (2011)Prior Document 2: Miklos Pless, Uri Weinberg, tumor treating fields: concept, evidence, future, Expert Opinion, 20(8), 1099-1106 (2011)
선행문헌 3: Angela M. Davies et al, Tumor treating fields: a new frontier in cancer therapy, Annals of the New York academy of sciences, 1291, 86-95 (2013)Prior Document 3: Angela M. Davies et al, Tumor treating fields: a new frontier in cancer therapy, Annals of the New York academy of sciences, 1291, 86-95 (2013)
선행문헌 4: Stupp et al, Effect of Tumor-Treating Fields Plus Maintenance Temozolomide vs Maintenance Temozolomide Alone on Survival in Patients With Glioblastoma: A Randomized Clinical Trial, Journal of the American Medical Association, 318(23), 2306-2316 (2017)Prior Document 4: Stupp et al, Effect of Tumor-Treating Fields Plus Maintenance Temozolomide vs Maintenance Temozolomide Alone on Survival in Patients With Glioblastoma: A Randomized Clinical Trial, Journal of the American Medical Association, 318(23), 2306-2316 (2017) )
선행문헌 5: Eilon D. Kirson et al. Alternating electric fields (TTFields) inhibit metastatic spread of solid tumors to the lungs, Clin Exp Metastasis 26, 633-640 (2009)Prior Literature 5: Eilon D. Kirson et al. Alternating electric fields (TTFields) inhibit metastatic spread of solid tumors to the lungs, Clin Exp Metastasis 26, 633-640 (2009)
선행문헌 6: Novocure Corporate Presentation (https://3sj0u94bgxp33grbz1fkt62h-wpengine.netdna-ssl.com/wp-content/uploads/2019/05/201905_NVCR_Corporate_Presentation_vFF.pdf)Prior Document 6: Novocure Corporate Presentation (https://3sj0u94bgxp33grbz1fkt62h-wpengine.netdna-ssl.com/wp-content/uploads/2019/05/201905_NVCR_Corporate_Presentation_vFF.pdf)
선행문헌 7: Eilon D. Kirson et al, alternating electric fields arrest cell proliferation in animal tumor models and human brain tumors, PNAS, 104(24), 10152-10157 (2007)Prior Document 7: Eilon D. Kirson et al, alternating electric fields arrest cell proliferation in animal tumor models and human brain tumors, PNAS, 104(24), 10152-10157 (2007)
따라서, 당해 기술분야에서는 전기장 치료 시에 피부에 부착된 전극에 의해 국소적으로 집중되는 임계 단위면적당 전류를 미연에 방지하면서 인체 내 전기장 크기를 증가시켜 암치료 효과를 극대화하면서도 피부 화상 등의 문제를 해결하기 위한 방안이 요구되고 있다.Therefore, in the art, when electric field treatment is performed, the current per critical unit area locally concentrated by the electrode attached to the skin is prevented in advance, and the size of the electric field in the human body is increased to maximize the cancer treatment effect while solving problems such as skin burns. A solution to the problem is required.
상기 과제를 해결하기 위해서, 본 발명의 일 실시예는 전기장 기반 암치료 장치를 제공한다.In order to solve the above problems, an embodiment of the present invention provides an electric field-based cancer treatment apparatus.
상기 전기장 기반 암치료 장치는, 환자의 환부를 감싸도록 코일형으로 이루어지며 교류 전류가 인가되는 코일형 도선을 포함하며, 상기 교류 전류가 인가된 코일형 도선에 의해 만들어진 자속변화를 통해 유도된 유도기전력을 상기 환자의 체내에 인가하는 것을 특징으로 한다.The electric field-based cancer treatment device is made in a coil shape to surround the affected part of the patient and includes a coiled conductor to which an alternating current is applied, and induction induced through a change in magnetic flux made by the coiled conductor to which the alternating current is applied. It is characterized in that the electromotive force is applied to the body of the patient.
일 실시예에 따르면, 상기 교류 전류는 10kHz 내지 300kHz 범위의 주파수 대역을 가지는 것을 특징으로 한다.According to one embodiment, the alternating current is characterized in that it has a frequency band in the range of 10 kHz to 300 kHz.
일 실시예에 따르면, 상기 코일형 도선은 내부 공간에 의해 상기 환자의 환부를 감싸도록 기하학적 구조를 갖는 것을 특징으로 한다.According to one embodiment, the coil-type conductor is characterized in that it has a geometric structure to surround the affected part of the patient by the internal space.
일 실시예에 따르면, 상기 코일형 도선과 상기 환자 사이에 구비되는 하나 이상의 전도성 매개체를 더 포함하는 것을 특징으로 한다.According to one embodiment, it characterized in that it further comprises one or more conductive media provided between the coil-type conductor and the patient.
일 실시예에 따르면, 상기 전도성 매개체는 상기 환자의 피부에 접촉 또는 인접하도록 환자 맞춤형으로 제작된 제1 매개체와, 상기 제1 매개체와 상기 코일형 도선 사이의 공간을 채우도록 고정된 형태로 제작된 제2 매개체를 포함하는 것을 특징으로 한다.According to one embodiment, the conductive medium is manufactured in a fixed form to fill a space between the first medium and the coiled conductor, and a first medium manufactured to be customized to the patient to be in contact with or adjacent to the skin of the patient. It is characterized in that it includes a second medium.
일 실시예에 따르면, 상기 전도성 매개체는 전기 전도도가 0.1 S/m 이상인 것을 특징으로 한다.According to one embodiment, the conductive medium is characterized in that the electrical conductivity is 0.1 S/m or more.
일 실시예에 따르면, 상기 전도성 매개체는 상대 투자율(Relative permeability)이 2 이상인 것을 특징으로 한다.According to one embodiment, the conductive medium is characterized in that the relative permeability (Relative permeability) is 2 or more.
일 실시예에 따르면, 상기 전기장 기반 암치료 장치는, 상기 전도성 매개체가 상기 환자의 신체에 부착되는 형태의 웨어러블 장치인 것을 특징으로 한다.According to an embodiment, the electric field-based cancer treatment device is a wearable device in which the conductive medium is attached to the body of the patient.
덧붙여 상기한 과제의 해결수단은, 본 발명의 특징을 모두 열거한 것이 아니다. 본 발명의 다양한 특징과 그에 따른 장점과 효과는 아래의 구체적인 실시형태를 참조하여 보다 상세하게 이해될 수 있을 것이다.Incidentally, the means for solving the above problems do not enumerate all the features of the present invention. Various features of the present invention and its advantages and effects may be understood in more detail with reference to the following specific embodiments.
본 발명의 일 실시예에 따르면, 전극을 피부에 부착하여 전기장을 인가하는 기존의 방식에서 탈피하여 인체 근처에서 교류 전류를 발생시키고 그로 인한 자속변화가 인체 내에 유도기전력을 발생시킴으로써 단위면적당 피부 전류는 일정 수준 이하로 유지하면서도 인체 내부의 전기장만을 극대화할 수 있다. 따라서, 종래 기술에 비해 높은 세기의 전기장을 환자 체내의 심부에 위치한 종양에 전달함으로써 암치료 효과는 증대시킬 수 있으면서도, 피부 화상 등의 부작용을 일으키는 피부 전류를 낮출 수 있다.According to an embodiment of the present invention, by breaking away from the conventional method of applying an electric field by attaching an electrode to the skin, an alternating current is generated near the human body, and the resulting change in magnetic flux generates an induced electromotive force in the human body, so that the skin current per unit area is It is possible to maximize only the electric field inside the human body while maintaining it below a certain level. Therefore, compared to the prior art, by delivering an electric field of high intensity to a tumor located deep within the patient's body, the cancer treatment effect can be increased, and the skin current that causes side effects such as skin burns can be lowered.
도 1은 전기장 치료시 전기장 세기 및 전기장 인가 시간에 따른 치료 효과 차이를 도시하는 도면이다.1 is a diagram illustrating a difference in treatment effect according to an electric field strength and an electric field application time during electric field treatment.
도 2는 본 발명의 일 실시예에 따른 전기장 기반 암치료 장치의 모식도이다.2 is a schematic diagram of an electric field-based cancer treatment apparatus according to an embodiment of the present invention.
도 3은 본 발명의 일 실시예에 따른 전기장 기반 암치료 장치에서 솔레노이드 내에 두경부 팬텀을 위치시키고 두경부 팬텀 내부에 인가되는 유도 전기장의 크기 및 전류 밀도를 계산한 결과를 도시하는 도면이다.3 is a diagram showing the results of calculating the magnitude and current density of an induced electric field applied to the inside of the head and neck phantom after positioning the head and neck phantom in the solenoid in the electric field-based cancer treatment apparatus according to an embodiment of the present invention.
도 4는 본 발명의 다른 실시예에 따른 전기장 기반 암치료 장치에서 솔레노이드 내에 전도성 매개체와 두경부 팬텀을 함께 위치시키고 두경부 팬텀 내부에 인가되는 유도 전기장의 크기 및 전류 밀도를 계산한 결과를 도시하는 도면이다.4 is a diagram showing the results of calculating the magnitude and current density of an induced electric field applied to the inside of the head and neck phantom by placing the conductive medium and the head and neck phantom together in the solenoid in the electric field-based cancer treatment device according to another embodiment of the present invention. .
도 5는 도 4에 도시된 본 발명의 실시예에서 두경부 팬텀의 중심에서 XY, XZ 및 YZ 평면에 대해 인가되는 유도 전기장의 분포와 크기를 도시하는 도면이다.FIG. 5 is a diagram illustrating the distribution and magnitude of the induced electric field applied to the XY, XZ and YZ planes at the center of the head and neck phantom in the embodiment of the present invention shown in FIG. 4 .
도 6은 도 4에 도시된 본 발명의 실시예에서 전류의 크기를 변화시키면서 두경부 팬텀의 중심에서 XY, XZ 및 YZ 평면에 대해 인가되는 유도 전기장의 분포와 크기를 도시하는 도면이다.6 is a view showing the distribution and magnitude of the induced electric field applied to the XY, XZ and YZ planes at the center of the head and neck phantom while changing the magnitude of the current in the embodiment of the present invention shown in FIG. 4 .
도 7은 도 4에 도시된 본 발명의 실시예에서 전류의 크기를 변화시키면서 두경부 팬텀에 전달되는 평균 전기장의 크기 및 피부에 흐르는 평균 전류 밀도를 계산한 결과를 도시하는 도면이다.FIG. 7 is a diagram illustrating the results of calculating the average electric field delivered to the head and neck phantom and the average current density flowing through the skin while changing the magnitude of the current in the embodiment of the present invention shown in FIG. 4 .
도 8은 도 4에 도시된 본 발명의 실시예에서 전류의 크기는 동일하게 유지하고 솔레노이드의 단위 길이당 권선수를 변화시키면서 두경부 팬텀의 중심에서 XY, XZ 및 YZ 평면에 대해 인가되는 유도 전기장의 분포와 크기를 도시하는 도면이다.8 shows the induced electric field applied to the XY, XZ and YZ planes from the center of the head and neck phantom while maintaining the same magnitude of current and changing the number of turns per unit length of the solenoid in the embodiment of the present invention shown in FIG. It is a diagram showing the distribution and size.
도 9는 도 4에 도시된 본 발명의 실시예에서 전류의 크기는 동일하게 유지하고 솔레노이드의 단위 길이당 권선수를 변화시키면서 두경부 팬텀에 전달되는 평균 전기장의 크기 및 피부에 흐르는 평균 전류 밀도를 계산한 결과를 도시하는 도면이다.9 shows the average electric field delivered to the head and neck phantom and the average current density flowing through the skin while maintaining the same magnitude of current and changing the number of turns per unit length of the solenoid in the embodiment of the present invention shown in FIG. 4 . It is a diagram showing one result.
도 10은 도 4에 도시된 본 발명의 실시예에서 전도성 매개체의 전도도를 변화시키면서 두경부 팬텀 내부에 인가되는 유도 전기장의 평균 크기를 계산한 결과를 도시하는 도면이다.FIG. 10 is a view showing the result of calculating the average magnitude of the induced electric field applied to the inside of the head and neck phantom while changing the conductivity of the conductive medium in the embodiment of the present invention shown in FIG. 4 .
도 11은 도 4에 도시된 본 발명의 실시예에서 전도성 매개체의 상대투자율을 변화시키면서 두경부 팬텀 내부에 인가되는 유도 전기장의 평균 크기를 계산한 결과를 도시하는 도면이다.FIG. 11 is a view showing the result of calculating the average magnitude of the induced electric field applied to the inside of the head and neck phantom while changing the relative permeability of the conductive medium in the embodiment of the present invention shown in FIG. 4 .
도 12는 본 발명의 다른 실시예에 따라 솔레노이드 내부에 위치하는 전도성 매개체가 두 개의 영역으로 분리되어 구현된 예를 도시하는 도면이다.12 is a diagram illustrating an example in which a conductive medium positioned inside a solenoid is separated into two regions according to another embodiment of the present invention.
이하, 첨부된 도면을 참조하여 본 발명이 속하는 기술분야에서 통상의 지식을 가진 자가 본 발명을 용이하게 실시할 수 있도록 바람직한 실시예를 상세히 설명한다. 다만, 본 발명의 바람직한 실시예를 상세하게 설명함에 있어, 관련된 공지 기능 또는 구성에 대한 구체적인 설명이 본 발명의 요지를 불필요하게 흐릴 수 있다고 판단되는 경우에는 그 상세한 설명을 생략한다. 또한, 유사한 기능 및 작용을 하는 부분에 대해서는 도면 전체에 걸쳐 동일한 부호를 사용한다.Hereinafter, preferred embodiments will be described in detail so that those of ordinary skill in the art can easily practice the present invention with reference to the accompanying drawings. However, in describing a preferred embodiment of the present invention in detail, if it is determined that a detailed description of a related known function or configuration may unnecessarily obscure the gist of the present invention, the detailed description thereof will be omitted. In addition, the same reference numerals are used throughout the drawings for parts having similar functions and functions.
덧붙여, 명세서 전체에서, 어떤 부분이 다른 부분과 '연결'되어 있다고 할 때, 이는 '직접적으로 연결'되어 있는 경우뿐만 아니라, 그 중간에 다른 소자를 사이에 두고 '간접적으로 연결'되어 있는 경우도 포함한다. 또한, 어떤 구성요소를 '포함'한다는 것은, 특별히 반대되는 기재가 없는 한 다른 구성요소를 제외하는 것이 아니라 다른 구성요소를 더 포함할 수 있다는 것을 의미한다.In addition, throughout the specification, when a part is 'connected' with another part, it is not only 'directly connected' but also 'indirectly connected' with another element interposed therebetween. include In addition, 'including' a certain component means that other components may be further included, rather than excluding other components, unless otherwise stated.
도 2는 본 발명의 일 실시예에 따른 전기장 기반 암치료 장치의 모식도이다.2 is a schematic diagram of an electric field-based cancer treatment apparatus according to an embodiment of the present invention.
도 2를 참조하면, 본 발명의 일 실시예에 따른 전기장 기반 암치료 장치(100)는, 환자(10)의 환부를 감싸도록 코일형으로 이루어지며 교류 전류가 인가되는 코일형 도선(110)을 포함할 수 있으며, 교류 전류가 인가된 코일형 도선(110)에 의해 만들어진 자속변화를 통해 유도된 유도기전력을 환자(10)의 체내에 인가할 수 있다. Referring to FIG. 2 , the electric field-based cancer treatment apparatus 100 according to an embodiment of the present invention is formed in a coil shape to surround the affected part of the patient 10 and a coil-type conductor 110 to which an alternating current is applied. may be included, and an induced electromotive force induced through a magnetic flux change made by the coiled conductor 110 to which an alternating current is applied may be applied to the body of the patient 10 .
여기서, 코일형 도선(110)에 인가되는 교류 전류는 10kHz 내지 300kHz 범위의 주파수 대역을 가질 수 있다.Here, the alternating current applied to the coiled conductor 110 may have a frequency band in the range of 10 kHz to 300 kHz.
또한, 코일형 도선(110)은 내부 공간에 의해 환자(10)의 환부를 감싸도록 기하학적 구조를 가질 수 있으며, 복수의 코일형 도선(110)이 어레이 형태로 연결된 것일 수도 있다. 본 발명의 실시예에서는, 코일형 도선(110)이 원통형 솔레노이드인 것으로 예시하였으나, 본 발명이 반드시 이로 제한되는 것은 아니며, 코일형 도선(110)은 직육면체, 삼각기둥 등과 같이 환자(10)의 환부에 최대의 유도기전력을 인가할 수 있는 다양한 형태의 기하학적 구조로 형성될 수 있다.In addition, the coiled conductor 110 may have a geometric structure to surround the affected part of the patient 10 by the internal space, and a plurality of coiled conductors 110 may be connected in an array form. In the embodiment of the present invention, the coil-type conductor 110 is exemplified as a cylindrical solenoid, but the present invention is not necessarily limited thereto, and the coil-type conductor 110 is a cuboid, a triangular prism, etc., the affected part of the patient 10 . It can be formed in various types of geometric structures that can apply the maximum induced electromotive force to the
또한, 코일형 도선(110)은 다른 형태의 전기장 발생수단(예를 들어, 교류 전기회로, 전자석 등)으로 대체될 수도 있다.In addition, the coil-type conducting wire 110 may be replaced with another type of electric field generating means (eg, an alternating current electric circuit, an electromagnet, etc.).
상술한 본 발명의 실시예에 따르면, 인체 내에 전기장을 인가하기 위해 적어도 한 쌍의 전극을 사용하는 기존의 전기장 암치료 방식에서 탈피하여 교류 전류가 흐르는 도선(예를 들어, 코일형 도선) 내부에 환자의 환부를 삽입함으로써 전극을 이용하지 않아도 도선 내부 공간의 자속변화에 의해 발생하는 유도전기장(induced electric field)을 환자 체내에 위치한 병변 부위에 인가할 수 있다. According to the above-described embodiment of the present invention, it breaks away from the existing electric field cancer treatment method that uses at least one pair of electrodes to apply an electric field to the human body, so that an alternating current flows inside a conducting wire (eg, a coil-type conducting wire). By inserting the affected part of the patient, an induced electric field generated by the magnetic flux change in the inner space of the conductor can be applied to the lesion site located in the patient's body without using an electrode.
본 발명의 실시예에 따른 전기장 기반 암치료 장치(100)는 이와 같은 원리를 이용하여 피부에 부착하는 전극을 사용함에 따라 발생하는 부작용들을 최소화함과 동시에 교류 전류의 세기를 조절함으로써 체내에 인가되는 전기장 크기를 조절할 수 있다.The electric field-based cancer treatment apparatus 100 according to an embodiment of the present invention minimizes side effects that occur when an electrode attached to the skin is used by using the same principle, and at the same time adjusts the intensity of an alternating current applied to the body. The electric field size can be adjusted.
또한, 본 발명의 일 실시예에 따르면, 코일형 도선(110)과 환자(10) 사이에 구비되는 하나 이상의 전도성 매개체(120)를 더 포함할 수 있으며, 전도성 매개체(120)는 환자(10)의 체내 전기장의 세기를 높여주는 역할을 하는 것이다.In addition, according to an embodiment of the present invention, one or more conductive media 120 provided between the coiled conductor 110 and the patient 10 may be further included, and the conductive media 120 is the patient 10 . It plays a role in increasing the strength of the electric field in the body.
여기서, 전도성 매개체(120)는 3차원 구조체로서, 생체 내 조직과 유사한 성분으로 구성된 매개체뿐만 아니라 전류가 흐를 수 있는 전도성을 가지는 부재를 지칭할 수 있다.Here, the conductive medium 120 is a three-dimensional structure, and may refer not only to a medium composed of components similar to in vivo tissues, but also to a member having conductivity through which current can flow.
또한, 전도성 매개체(120)는 전기 전도도가 0.1 S/m 이상이고, 상대 투자율(Relative permeability)이 2 이상일 수 있다.In addition, the conductive medium 120 may have an electrical conductivity of 0.1 S/m or more, and a relative permeability of 2 or more.
일 실시예에 따르면, 도 2를 참조하여 상술한 전기장 기반 암치료 장치(100)는, 전도성 매개체(120)가 환자의 신체(10)에 부착되는 형태의 웨어러블 장치로 구현될 수 있다.According to one embodiment, the electric field-based cancer treatment apparatus 100 described above with reference to FIG. 2 may be implemented as a wearable device in which the conductive medium 120 is attached to the patient's body 10 .
도 3은 본 발명의 일 실시예에 따른 전기장 기반 암치료 장치에서 솔레노이드 내에 두경부 팬텀을 위치시키고 두경부 팬텀 내부에 인가되는 유도 전기장의 크기 및 전류 밀도를 계산한 결과를 도시하는 도면으로, 구체적으로 1cm 당 도선이 25번 감긴 20cm 지름의 원통형 솔레노이드에 교류 전류 1A를 인가하였을 때 위치에 따라 인가되는 유도 전기장의 크기(Field Intensity)와 전류 밀도(Current Density)를 시뮬레이션한 결과를 도시한다. 여기서, 사용되는 두경부 팬텀은 물리적인 크기와 전기적 특성이 인체와 유사하도록 제작된 것이다.3 is a view showing the results of calculating the magnitude and current density of an induced electric field applied to the inside of the head and neck phantom by positioning the head and neck phantom in the solenoid in the electric field-based cancer treatment device according to an embodiment of the present invention, specifically 1 cm The simulation results of the induced electric field (Field Intensity) and current density (Current Density) applied depending on the position when an alternating current of 1A is applied to a cylindrical solenoid with a diameter of 20 cm with 25 turns of the conductor is shown. Here, the head and neck phantom used is manufactured so that the physical size and electrical characteristics are similar to those of the human body.
또한, 도 4는 본 발명의 다른 실시예에 따른 전기장 기반 암치료 장치에서 솔레노이드 내에 전도성 매개체와 두경부 팬텀을 함께 위치시키고 두경부 팬텀 내부에 인가되는 유도 전기장의 크기 및 전류 밀도를 계산한 결과를 도시하는 도면으로, 구체적으로 1cm 당 도선이 25번 감긴 100cm 지름의 원통형 솔레노이드 내부 공간에 원통형 전도성 매개체와 두경부 팬텀을 함께 위치시키고 원통형 솔레노이드에 교류 전류 1A를 인가하였을 때 위치에 따라 인가되는 유도 전기장의 크기와 전류 밀도를 시뮬레이션한 결과를 도시한다.In addition, FIG. 4 is an electric field-based cancer treatment device according to another embodiment of the present invention, in which a conductive medium and a head and neck phantom are placed together in a solenoid, and the magnitude and current density of the induced electric field applied to the inside of the head and neck phantom are calculated. In the drawing, specifically, when a cylindrical conductive medium and a head and neck phantom are placed together in the inner space of a cylindrical solenoid with a diameter of 100 cm in which a wire is wound 25 times per 1 cm, and an alternating current of 1A is applied to the cylindrical solenoid, the magnitude of the induced electric field applied according to the position The simulation results of the current density are shown.
또한, 도 5는 도 4에 도시된 본 발명의 실시예에서 두경부 팬텀의 중심에서 XY, XZ 및 YZ 평면에 대해 인가되는 유도 전기장의 분포와 크기를 도시하는 도면이다.In addition, FIG. 5 is a diagram illustrating the distribution and magnitude of the induced electric field applied to the XY, XZ and YZ planes at the center of the head and neck phantom in the embodiment of the present invention shown in FIG. 4 .
도 3 내지 도 5를 참조하면, 원통형 솔레노이드의 내부 공간이 충분히 크고, 두경부 팬텀의 위치가 원통형 솔레노이드 내부 중심에서 멀어질수록 더 큰 전기장이 인가되는 것을 알 수 있다. 이와 같은 특성에 기인하여, 본 발명의 실시예에서 두경부 팬텀 또는 환자의 환부는 원통형 솔레노이드 중심으로부터 기 설정된 거리 이상 떨어진 지점에 위치하는 것이 바람직하다.3 to 5 , it can be seen that the inner space of the cylindrical solenoid is sufficiently large, and the greater the electric field is applied as the position of the head and neck phantom is farther from the inner center of the cylindrical solenoid. Due to these characteristics, in the embodiment of the present invention, the head and neck phantom or the affected part of the patient is preferably located at a point more than a preset distance from the center of the cylindrical solenoid.
또한, 본 발명의 일 실시예에 따라 전도성 매개체를 함께 사용하는 경우, 두경부 팬텀의 중심에 인가되는 전기장의 크기도 약 4V/cm로 기존의 전극을 이용한 방법에 비해 전기장 크기를 약 2배 이상 증가시킬 수 있음을 알 수 있다.In addition, when a conductive medium is used together according to an embodiment of the present invention, the magnitude of the electric field applied to the center of the head and neck phantom is also about 4 V/cm, which increases the electric field by about 2 times or more compared to the method using the conventional electrode. know that it can be done.
또한, 본 발명의 실시예에 따르면, 전극을 이용하지 않으므로 피부 전류밀도가 약 6mA/cm2 이하로 권고 한계전류인 30mA/cm2보다 작아서 전류에 따른 부작용이 최소화 된다는 이점이 있다.In addition, according to the embodiment of the present invention, since the electrode is not used, the skin current density is about 6 mA/cm 2 or less, which is less than the recommended limit current of 30 mA/cm 2 , so that side effects due to the current are minimized.
도 6은 도 4에 도시된 본 발명의 실시예에서 전류의 크기를 변화시키면서 두경부 팬텀의 중심에서 XY, XZ 및 YZ 평면에 대해 인가되는 유도 전기장의 분포와 크기를 도시하는 도면으로, 구체적으로 인가하는 교류 전류의 크기를 1A, 2A 및 3A로 변화시켰을 때 두경부 팬텀 내부에 걸리는 전기장의 분포를 도시한다.6 is a view showing the distribution and magnitude of the induced electric field applied to the XY, XZ and YZ planes at the center of the head and neck phantom while changing the magnitude of the current in the embodiment of the present invention shown in FIG. The distribution of the electric field applied to the inside of the head and neck phantom is shown when the magnitude of the alternating current is changed to 1A, 2A, and 3A.
또한, 도 7은 도 4에 도시된 본 발명의 실시예에서 전류의 크기를 변화시키면서 두경부 팬텀에 전달되는 평균 전기장의 크기 및 피부에 흐르는 평균 전류 밀도를 계산한 결과를 도시하는 도면으로, 구체적으로 인가하는 교류 전류의 크기를 1A, 2A, 3A 및 4A로 변화시켰을 때 두경부 팬텀 내부에 분포하는 전기장 크기의 평균값과 표면에 인가된 전류밀도의 평균값을 계산한 결과를 도시한다.In addition, FIG. 7 is a view showing the results of calculating the average electric field delivered to the head and neck phantom and the average current density flowing through the skin while changing the magnitude of the current in the embodiment of the present invention shown in FIG. 4 . Specifically, FIG. The results of calculating the average value of the magnitude of the electric field distributed inside the head and neck phantom and the average value of the current density applied to the surface are shown when the magnitude of the applied AC current is changed to 1A, 2A, 3A, and 4A.
또한, 도 8은 도 4에 도시된 본 발명의 실시예에서 전류의 크기는 동일하게 유지하고 솔레노이드의 단위 길이당 권선수를 변화시키면서 두경부 팬텀의 중심에서 XY, XZ 및 YZ 평면에 대해 인가되는 유도 전기장의 분포와 크기를 도시하는 도면으로, 구체적으로 교류 전류의 크기를 1A로 일정하게 유지하고 1cm당 도선이 감긴 횟수를 25번, 50번 및 75번으로 변화시켰을 때 두경부 팬텀 내부에 걸리는 전기장의 분포를 도시한다.In addition, FIG. 8 shows induction applied to the XY, XZ and YZ planes at the center of the head and neck phantom while maintaining the same magnitude of current and changing the number of turns per unit length of the solenoid in the embodiment of the present invention shown in FIG. This is a diagram showing the distribution and magnitude of the electric field. Specifically, when the magnitude of the alternating current is kept constant at 1A and the number of turns of the conductor per cm is changed to 25, 50, and 75, the electric field applied inside the head and neck phantom The distribution is shown.
또한, 도 9는 도 4에 도시된 본 발명의 실시예에서 전류의 크기는 동일하게 유지하고 솔레노이드의 단위 길이당 권선수를 변화시키면서 두경부 팬텀에 전달되는 평균 전기장의 크기 및 피부에 흐르는 평균 전류 밀도를 계산한 결과를 도시하는 도면으로, 구체적으로 교류 전류의 크기를 1A로 일정하게 유지하고 1cm당 도선이 감긴 횟수를 25번, 50번, 75번 및 100번으로 변화시켰을 때 두경부 팬텀 내부에 분포하는 전기장 크기의 평균값과 표면에 인가된 전류밀도의 평균값을 계산한 결과를 도시한다.In addition, FIG. 9 shows the size of the average electric field delivered to the head and neck phantom and the average current density flowing through the skin while maintaining the same current magnitude and changing the number of turns per unit length of the solenoid in the embodiment of the present invention shown in FIG. This is a diagram showing the result of calculating . Specifically, distribution inside the head and neck phantom when the size of the alternating current is kept constant at 1A and the number of turns per cm of the conductor is changed to 25, 50, 75, and 100 times. The results of calculating the average value of the magnitude of the electric field and the average value of the current density applied to the surface are shown.
도 6 내지 도 9를 참조하면, 원통형 솔레노이드에 인가하는 교류 전류의 크기를 1A, 2A, 3A 및 4A로 변화시켜 주었을 때와, 1cm 당 도선이 감긴 횟수를 25번, 50번, 75번 및 100번으로 변화시켜 주었을 때, 두경부 팬텀의 표면에 약 20mA/cm2 이하의 전류밀도를 유지함으로써 직접적인 부작용을 주지 않으면서 두경부 팬텀 내부에 걸리는 평균 전기장 크기는 17.3V/cm까지 증가시킬 수 있음을 알 수 있다.6 to 9, when the magnitude of the alternating current applied to the cylindrical solenoid was changed to 1A, 2A, 3A, and 4A, and the number of turns of the conductor per 1 cm was 25, 50, 75, and 100 It was found that the average electric field applied inside the head and neck phantom can be increased to 17.3 V/cm without direct side effects by maintaining the current density of less than about 20 mA/cm 2 on the surface of the head and neck phantom. can
특히, 도 6을 참조하면, 원통형 솔레노이드에 각각 2A 및 3A의 교류 전류를 인가하였을 때, 두경부 팬텀 중심에 위치하는 종양에 각각 최대 8V/cm 및 12V/cm까지 전기장을 인가할 수 있음을 알 수 있고, 이는 기존의 방식으로 인가할 수 있는 전기장 크기(약 2V/cm) 대비 약 400% 내지 600% 향상시킬 수 있음을 알 수 있다.In particular, referring to Figure 6, when 2A and 3A alternating current is applied to the cylindrical solenoid, respectively, it can be seen that up to 8V/cm and 12V/cm of electric fields can be applied to the tumor located at the center of the head and neck phantom, respectively. and it can be seen that it can be improved by about 400% to 600% compared to the magnitude of the electric field (about 2V/cm) that can be applied in the conventional way.
도 10은 도 4에 도시된 본 발명의 실시예에서 전도성 매개체의 전도도를 변화시키면서 두경부 팬텀 내부에 인가되는 유도 전기장의 평균 크기를 계산한 결과를 도시하는 도면이고, 도 11은 도 4에 도시된 본 발명의 실시예에서 전도성 매개체의 상대투자율을 변화시키면서 두경부 팬텀 내부에 인가되는 유도 전기장의 평균 크기를 계산한 결과를 도시하는 도면이다.10 is a view showing the result of calculating the average magnitude of the induced electric field applied to the inside of the head and neck phantom while changing the conductivity of the conductive medium in the embodiment of the present invention shown in FIG. It is a diagram showing the result of calculating the average magnitude of the induced electric field applied to the inside of the head and neck phantom while changing the relative permeability of the conductive medium in the embodiment of the present invention.
도 10 및 도 11을 참조하면, 전도성 매개체의 전기 전도도 및 상대 투자율이 각각 일정 크기 이상일 때 두경부 팬텀 내의 전기장 상승 효과가 나타남을 알 수 있다. 구체적으로, 전기 전도도는 0.1 S/m 이상, 그리고 상대 투자율은 2 이상인 경우 전기장 상승 효과가 있으며, 특히 전기 전도도가 6 S/m 내지 20 S/m 범위에 속하는 경우 가장 큰 전기장 상승 효과를 나타냄을 알 수 있다.Referring to FIGS. 10 and 11 , it can be seen that the electric field synergistic effect in the head and neck phantom occurs when the electrical conductivity and the relative permeability of the conductive medium are respectively greater than a certain size. Specifically, when the electrical conductivity is 0.1 S/m or more, and the relative permeability is 2 or more, there is an electric field synergistic effect, and in particular, when the electrical conductivity is in the range of 6 S/m to 20 S/m, the largest electric field synergistic effect is shown. Able to know.
도 12는 본 발명의 다른 실시예에 따라 솔레노이드 내부에 위치하는 전도성 매개체가 두 개의 영역으로 분리되어 구현된 예를 도시하는 도면이다.12 is a diagram illustrating an example in which a conductive medium positioned inside a solenoid is separated into two regions according to another embodiment of the present invention.
도 12에 도시된 바와 같이, 전도성 매개체(120)는 환자(10)의 피부에 접촉 또는 인접하도록 환자 맞춤형으로 제작된 제1 매개체(즉, 환자 맞춤형 매개체(Customized Conducting Medium))(121)와, 제1 매개체(121)와 코일형 도선(110) 사이의 공간을 채우도록 고정된 형태로 제작된 제2 매개체(즉, 고정 형상 매개체(Fixed Shape of Medium))(122)로 분리되어 구현될 수 있다.As shown in Figure 12, the conductive medium 120 is a first medium (that is, the patient-customized medium (Customized Conducting Medium)) 121 manufactured to be in contact with or adjacent to the skin of the patient 10, and, The second medium (ie, fixed shape of medium) 122 manufactured in a fixed shape to fill the space between the first medium 121 and the coiled conductor 110 may be implemented separately. there is.
이 경우, 환자(10)에 직접 접촉 또는 인접하는 제1 매개체(121)만 각각의 환자별로 맞춤형으로 제작하고, 제2 매개체(122)는 복수의 환자에 대해 공용으로 사용 가능하여 보다 효율적으로 전기장 기반 암치료 장치를 구현할 수 있다.In this case, only the first medium 121 in direct contact with or adjacent to the patient 10 is customized for each patient, and the second medium 122 can be used in common for a plurality of patients, so that the electric field more efficiently It is possible to implement a cancer-based treatment device.
상술한 실시예에 따른 전기장 기반 암치료 장치는 예를 들어 원통형의 전기장 발생기의 내부에 환자가 들어가서 치료를 받는 방식으로 구현될 수 있고, 상술한 실시예에 따르면 체내에 높은 전기장을 인가할 수 있어 전극을 기반으로 하는 기존 방식과 달리 짧은 시간 동안 고-전기장 치료가 가능하며, 이에 따라 보다 우수한 전기장 치료 효과를 달성할 수 있다.The electric field-based cancer treatment apparatus according to the above-described embodiment may be implemented in such a way that, for example, a patient enters the inside of a cylindrical electric field generator to receive treatment, and according to the above-described embodiment, a high electric field can be applied to the body. Unlike conventional methods based on electrodes, high-electric field treatment is possible for a short period of time, and thus a better electric field treatment effect can be achieved.
본 발명은 전술한 실시예 및 첨부된 도면에 의해 한정되는 것이 아니다. 본 발명이 속하는 기술분야에서 통상의 지식을 가진 자에게 있어, 본 발명의 기술적 사상을 벗어나지 않는 범위 내에서 본 발명에 따른 구성요소를 치환, 변형 및 변경할 수 있다는 것이 명백할 것이다.The present invention is not limited by the above embodiments and the accompanying drawings. For those of ordinary skill in the art to which the present invention pertains, it will be apparent that components according to the present invention can be substituted, modified and changed without departing from the technical spirit of the present invention.
Claims (8)
- 환자의 환부를 감싸도록 코일형으로 이루어지며 교류 전류가 인가되는 코일형 도선을 포함하며,It is made in a coil shape to cover the affected part of the patient and includes a coil-type conductor to which an alternating current is applied,상기 교류 전류가 인가된 코일형 도선에 의해 만들어진 자속변화를 통해 유도된 유도기전력을 상기 환자의 체내에 인가하는 것을 특징으로 하는 전기장 기반 암치료 장치.An electric field-based cancer treatment device, characterized in that for applying an induced electromotive force induced through a magnetic flux change made by the coil-type conductor to which the alternating current is applied to the body of the patient.
- 제 1 항에 있어서,The method of claim 1,상기 교류 전류는 10kHz 내지 300kHz 범위의 주파수 대역을 가지는 것을 특징으로 하는 전기장 기반 암치료 장치.The alternating current is an electric field-based cancer treatment device, characterized in that it has a frequency band in the range of 10kHz to 300kHz.
- 제 1 항에 있어서, The method of claim 1,상기 코일형 도선은 내부 공간에 의해 상기 환자의 환부를 감싸도록 기하학적 구조를 갖는 것을 특징으로 하는 전기장 기반 암치료 장치.The electric field-based cancer treatment device, characterized in that the coil-type conductor has a geometric structure to surround the affected part of the patient by the internal space.
- 제 1 항에 있어서,The method of claim 1,상기 코일형 도선과 상기 환자 사이에 구비되는 하나 이상의 전도성 매개체를 더 포함하는 것을 특징으로 하는 전기장 기반 암치료 장치.Electric field-based cancer treatment device, characterized in that it further comprises one or more conductive media provided between the coil-type conductor and the patient.
- 제 4 항에 있어서,5. The method of claim 4,상기 전도성 매개체는 상기 환자의 피부에 접촉 또는 인접하도록 환자 맞춤형으로 제작된 제1 매개체와, 상기 제1 매개체와 상기 코일형 도선 사이의 공간을 채우도록 고정된 형태로 제작된 제2 매개체를 포함하는 것을 특징으로 하는 전기장 기반 암치료 장치.The conductive medium includes a first medium customized to the patient so as to be in contact with or adjacent to the patient's skin, and a second medium manufactured in a fixed form to fill the space between the first medium and the coiled conductor. Electric field-based cancer treatment device, characterized in that.
- 제 4 항에 있어서, 5. The method of claim 4,상기 전도성 매개체는 전기 전도도가 0.1 S/m 이상인 것을 특징으로 하는 전기장 기반 암치료 장치.The electric field-based cancer treatment device, characterized in that the conductive medium has an electrical conductivity of 0.1 S/m or more.
- 제 4 항에 있어서, 5. The method of claim 4,상기 전도성 매개체는 상대 투자율(Relative permeability)이 2 이상인 것을 특징으로 하는 전기장 기반 암치료 장치.The electric field-based cancer treatment device, characterized in that the conductive medium has a relative permeability of 2 or more.
- 제 4 항에 있어서, 상기 전기장 기반 암치료 장치는, According to claim 4, wherein the electric field-based cancer treatment device,상기 전도성 매개체가 상기 환자의 신체에 부착되는 형태의 웨어러블 장치인 것을 특징으로 하는 전기장 기반 암치료 장치.The electric field-based cancer treatment device, characterized in that the conductive medium is a wearable device attached to the patient's body.
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