WO2021137740A3 - Molecular computing device based on essentially single stranded nucleic acids - Google Patents

Molecular computing device based on essentially single stranded nucleic acids Download PDF

Info

Publication number
WO2021137740A3
WO2021137740A3 PCT/RU2020/050402 RU2020050402W WO2021137740A3 WO 2021137740 A3 WO2021137740 A3 WO 2021137740A3 RU 2020050402 W RU2020050402 W RU 2020050402W WO 2021137740 A3 WO2021137740 A3 WO 2021137740A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acids
stranded nucleic
molecular
computing device
molecules
Prior art date
Application number
PCT/RU2020/050402
Other languages
French (fr)
Other versions
WO2021137740A2 (en
Inventor
Maxim Petrovich NIKITIN
Original Assignee
Nikitin Maxim Petrovich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nikitin Maxim Petrovich filed Critical Nikitin Maxim Petrovich
Publication of WO2021137740A2 publication Critical patent/WO2021137740A2/en
Publication of WO2021137740A3 publication Critical patent/WO2021137740A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00—Computing arrangements based on biological models
    • G06N3/002—Biomolecular computers, i.e. using biomolecules, proteins, cells
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00—Computing arrangements based on biological models
    • G06N3/12—Computing arrangements based on biological models using genetic models
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00—Computing arrangements based on biological models
    • G06N3/12—Computing arrangements based on biological models using genetic models
    • G06N3/123—DNA computing
    • H—ELECTRICITY
    • H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10K—ORGANIC ELECTRIC SOLID-STATE DEVICES
    • H10K10/00—Organic devices specially adapted for rectifying, amplifying, oscillating or switching; Organic capacitors or resistors having a potential-jump barrier or a surface barrier
    • H10K10/701—Organic molecular electronic devices
    • H—ELECTRICITY
    • H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10K—ORGANIC ELECTRIC SOLID-STATE DEVICES
    • H10K85/00—Organic materials used in the body or electrodes of devices covered by this subclass
    • H10K85/761—Biomolecules or bio-macromolecules, e.g. proteins, chlorophyl, lipids or enzymes

Abstract

The invention relates to the field of molecular computing devices. The essence of the invention consists in a molecular computing device that comprises a set of single-stranded nucleic acids, and for which input signals are transformed into output signals as a result of interactions between input molecules, said single-stranded nucleic acids of said set, and output molecules, characterized in that said single-stranded nucleic acids have low affinity to each other: at least 0.1% of the amount of each of them exists in free molecular form, and is not included in the complexes with other molecules. The technical effect of using the invention is in acceleration of molecular computations, expanding the range of problems to be solved (problems of Boolean algebra and elementary algebra with continuously changing values of variables), as well as in the possibility of using oligonucleotides of various lengths (less than 10 nucleotides) for performing computations.
PCT/RU2020/050402 2019-12-31 2020-12-29 Molecular computing device based on essentially non-complementary single stranded nucleic acids with low mutual affinity WO2021137740A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2019145384 2019-12-31
RU2019145384A RU2756476C2 (en) 2019-12-31 2019-12-31 Molecular computing device based on essentially non-complementary single-stranded nucleic acids with low affinity to each other (options)

Publications (2)

Publication Number Publication Date
WO2021137740A2 WO2021137740A2 (en) 2021-07-08
WO2021137740A3 true WO2021137740A3 (en) 2021-08-12

Family

ID=76687189

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/RU2020/050402 WO2021137740A2 (en) 2019-12-31 2020-12-29 Molecular computing device based on essentially non-complementary single stranded nucleic acids with low mutual affinity

Country Status (2)

Country Link
RU (1) RU2756476C2 (en)
WO (1) WO2021137740A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999042929A1 (en) * 1998-02-20 1999-08-26 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Molecular computing elements: gates and flip-flops
US20040235043A1 (en) * 1998-02-20 2004-11-25 Department Of Health And Human Service National Institutes Of Health Office Of Technology Transfer Molecular computing elements: gates and flip-flops
US20070072215A1 (en) * 2005-07-21 2007-03-29 The California Institute Of Technology Nucleic acid-based logic circuits
WO2013151465A1 (en) * 2012-04-02 2013-10-10 Nikitin Maxim Petrovich Logic element complex based on biomolecules (variants)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8865667B2 (en) * 2007-09-12 2014-10-21 California Institute Of Technology Higher-order cellular information processing devices
WO2011116151A2 (en) * 2010-03-16 2011-09-22 The Regents Of The University Of California Enzyme-logic biosensing

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999042929A1 (en) * 1998-02-20 1999-08-26 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Molecular computing elements: gates and flip-flops
US20040235043A1 (en) * 1998-02-20 2004-11-25 Department Of Health And Human Service National Institutes Of Health Office Of Technology Transfer Molecular computing elements: gates and flip-flops
US20070072215A1 (en) * 2005-07-21 2007-03-29 The California Institute Of Technology Nucleic acid-based logic circuits
WO2013151465A1 (en) * 2012-04-02 2013-10-10 Nikitin Maxim Petrovich Logic element complex based on biomolecules (variants)

Also Published As

Publication number Publication date
RU2019145384A (en) 2021-06-30
RU2756476C2 (en) 2021-09-30
WO2021137740A2 (en) 2021-07-08
RU2019145384A3 (en) 2021-06-30

Similar Documents

Publication Publication Date Title
Lu et al. Mathematical methods via construction of traveling and solitary wave solutions of three coupled system of nonlinear partial differential equations and their applications
Wang et al. Positive solutions of an abstract fractional semipositone differential system model for bioprocesses of HIV infection
WO2017037304A3 (en) An assembly system for a eukaryotic cell
Kumar et al. On Tamed Milstein Schemes of SDEs Driven by L\'evy Noise
Thakre et al. Performance Evaluation and Synthesis of Multiplier used in FFT operation using Conventional and Vedic algorithms
WO2021137740A3 (en) Molecular computing device based on essentially single stranded nucleic acids
Sababheh Interpolated inequalities for unitarily invariant norms
Mirzaee et al. Numerical solution of two-dimensional fuzzy Fredholm integral equations of the second kind using triangular functions
Baruah et al. Infinite families of arithmetic identities and congruences for bipartitions with 3-cores
Zhang et al. Design of logic circuits based on combinatorial displacement of DNA strands
Guo et al. The compound (G′ G)-expansion method and double non-traveling wave solutions of (2+ 1)-dimensional nonlinear partial differential equations
WO2023003737A3 (en) Multi-lane cryptographic engine and operations thereof
CN104391823A (en) Method for solving nodal impedance matrix of electric system on basis of triangular decomposition method of A=LDU
CN106919536A (en) A kind of accelerated method and its accelerator for being applied to triangular matrix and matrix multiplication
Ouyang et al. Travelling wave solutions of nonlinear dynamical equations in a double-chain model of DNA
Mir et al. A mathematical study of DNA complexes of onebond edge type
Al-Kadi Soft BCL-algebra
Pandir et al. A new version of the generalized F-expansion method and its applications
Ugurlu et al. Various exact solutions of some nonlinear equations by a direct algebraic method
Ding et al. A improved F‐expansion method and its application to the Zhiber–Shabat equation
Richardson The super Patalan numbers
Ernst Factorizations for q-Pascal matrices of two variables
Matsuda et al. Cascading Whiplash PCR with a nicking enzyme
Bakodah et al. Application of the New Modified Decomposition Method to the Regularized Long-Wave Equation
Mohamad et al. Compatible pair of actions for two same cyclic groups of 2-power order

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 20910702

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 20910702

Country of ref document: EP

Kind code of ref document: A2