WO2021129403A1 - Système, procédé et appareil de surveillance pour l'état d'entraînement d'une commande de dosage - Google Patents

Système, procédé et appareil de surveillance pour l'état d'entraînement d'une commande de dosage Download PDF

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Publication number
WO2021129403A1
WO2021129403A1 PCT/CN2020/135160 CN2020135160W WO2021129403A1 WO 2021129403 A1 WO2021129403 A1 WO 2021129403A1 CN 2020135160 W CN2020135160 W CN 2020135160W WO 2021129403 A1 WO2021129403 A1 WO 2021129403A1
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WO
WIPO (PCT)
Prior art keywords
motor
push rod
controller
monitoring system
drug delivery
Prior art date
Application number
PCT/CN2020/135160
Other languages
English (en)
Chinese (zh)
Inventor
郑攀
道尔马克
宣佳杰
宋哲
Original Assignee
微泰医疗器械(杭州)有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 微泰医疗器械(杭州)有限公司 filed Critical 微泰医疗器械(杭州)有限公司
Publication of WO2021129403A1 publication Critical patent/WO2021129403A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16804—Flow controllers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16831—Monitoring, detecting, signalling or eliminating infusion flow anomalies
    • A61M5/16854—Monitoring, detecting, signalling or eliminating infusion flow anomalies by monitoring line pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16877—Adjusting flow; Devices for setting a flow rate

Definitions

  • the device for detecting the initial position of the push rod includes two parts of conductive contacts and an elastic conductive material connected between the two parts, and the elastic conductive material is arranged on the surface of the push rod; the controller is also used in the motor In the starting state, the resistance between the two conductive contacts is detected and the motor is stopped when the resistance is less than a preset value.
  • the infusion pressure sensor is a sheet-type pressure sensor, which is installed between the end face of the screw rod and the fixed end face in the gear box.
  • a method for monitoring the driving transmission state of drug delivery is applied to the monitoring system of the present invention.
  • the method includes: the controller confirms that the push rod is located at the initial bottom position according to the information provided by the initial position detection device of the push rod;
  • the medicine instruction is to start the motor at the time when the medicine is needed and receive the current motor stroke data provided by the motor rotation amount monitoring device, and stop the motor when the stroke reaches a specified value.
  • the instruction value is determined by the amount of medicine in the medicine instruction , The cross-sectional area of the medicine bin and the lead of the screw rod are determined.
  • a drug delivery drive transmission state monitoring device is provided in the controller of the present invention.
  • the device includes: a push rod position confirmation module for confirming that the push rod is located at the initial bottom position according to the information provided by the push rod initial position detection device;
  • the drug delivery module is used to start the motor at the time when the drug is needed according to the pre-set drug delivery instructions and receive the current motor stroke data provided by the motor rotation monitoring device, and stop the motor when the stroke reaches the specified value.
  • the value is determined by the dose, the cross-sectional area of the drug bin, and the lead of the screw rod in the dosing instruction;
  • the infusion pressure monitoring module is used to receive the infusion pressure when the motor is activated
  • the pressure information provided by the sensor when the pressure is greater than or equal to the set value, output alarm information.
  • an insulin pump is taken as an example to describe the embodiments of the present invention.
  • FIG. 1 is a schematic diagram of the components of an insulin pump system according to an embodiment of the present invention.
  • the drug dispenser 100, the battery 200 and the drug storage device 300 are three independent parts, which are spliced into an insulin pump system during use.
  • the battery 200 is placed in the drug storage device 300.
  • the drug storage device 300 and the drug storage device 100 are located near the docking surface. , One has a slightly larger caliber than the other, so the two can be partially socketed, as shown in Figure 1.
  • Fig. 2 is a schematic diagram of one side of the applicator according to an embodiment of the present invention
  • Fig. 3 is a schematic diagram of the other side of the applicator.
  • the applicator 100 is a reusable part, including a housing 1, a transmission assembly and a circuit board assembly; the transmission assembly and the circuit board assembly are arranged in the housing 1, and one end surface of the housing 1 is Docking surface 17; transmission components include motor 2, gear box 3, coaxial and threaded screw rod 4 and push rod 5, motor 2 is connected to the circuit board assembly, motor 2, gear box 3 and push rod 5 are arranged in a U shape , The U-shaped opening faces the mating surface 17, the output end of the motor 2 is connected to one end of the gear box 3, the other end of the gear box 3 is connected to the screw rod 4, and the end of the push rod 5 away from the gear box 3 passes through the mating surface 17 so as to Located on the outside of the housing 1; the circuit board assembly includes a printed circuit board 6, a battery connector 7 and
  • the controller can be used to start the motor at the time when the drug is required according to the pre-set administration instruction and receive the travel information provided by the motor rotation monitoring device. Stop the motor when the stroke reaches the specified value.
  • the user can edit the medication information in a terminal device, and the terminal device converts it into medication instructions that can be used by the program in the controller, which mainly includes the time of medication and the stroke of the stepper motor reflecting the amount of medication , And then send it to the controller in a wireless manner such as infrared or Bluetooth.
  • the above-mentioned specified value is determined by the dose, the cross-sectional area of the drug chamber, and the lead of the screw in the dosing instruction.
  • the administration time and dosage can be set by the user when using the above-mentioned terminal device.
  • the terminal device can calculate the distance that the screw rod advances for each step of the motor according to the lead, the pitch diameter and the transmission ratio of the gearbox, and then combine the dose of this time and the cross-sectional area of the drug bin to get the time of this drug delivery.
  • the number of steps the motor should step that is, the specified value above. Obtain the number of steps of the motor during the infusion, and stop the motor when the number of steps the motor should be stepped during this administration is reached.
  • FIG. 5 is a schematic diagram of a device for obtaining the number of steps of a stepping motor according to an embodiment of the present invention.
  • an impeller 502 is installed on the rotating shaft 501 of the stepper motor 500, on the inner wall of the housing near the impeller or a base extending from the inner wall of the housing, or in the cavity where the stepper motor 500 is located.
  • the first light sensor 503 and the second light sensor 504 are fixed, and the angle between the two is an integer multiple of the step length (in angle) of the rotation of the stepping motor.

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

Un système, un procédé et un appareil de surveillance pour un état d'entraînement d'une commande de dosage, destinés à être utilisés pour améliorer la précision et la fiabilité d'un dosage automatique par une pompe à insuline. Le système de surveillance est conçu pour commander un dispositif de dosage (100) pour pousser un piston dans une seringue de façon à extruder un médicament liquide à travers une aiguille pour une injection sous-cutanée ; le dispositif de dosage (100) comprend un moteur (2), une boîte de vitesses (3) ainsi qu'une tige de vis (4) et une tige de poussée (5) qui sont coaxiales et en liaison filetée ; l'extrémité de sortie du moteur (2) est reliée à une extrémité de la boîte de vitesses (3), l'autre extrémité de la boîte de vitesses (3) est reliée à la tige de vis (4), et la tige de poussée (5) et le piston butent l'un contre l'autre. Le système de surveillance comprend un moyen de surveillance de quantité de rotation de moteur, un moyen de détection de position initiale de tige de poussée, et un dispositif de commande ; le dispositif de commande est conçu pour démarrer le moteur (2) selon une instruction de dosage prédéfinie lorsque le dosage est nécessaire, recevoir des informations de déplacement fournies par le moyen de surveillance de quantité de rotation de moteur, et arrêter le moteur (2) lorsque la course atteint une valeur spécifiée.
PCT/CN2020/135160 2019-12-24 2020-12-10 Système, procédé et appareil de surveillance pour l'état d'entraînement d'une commande de dosage WO2021129403A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201911345149.2A CN111135381A (zh) 2019-12-24 2019-12-24 给药驱动传动状态监控***和方法以及装置
CN201911345149.2 2019-12-24

Publications (1)

Publication Number Publication Date
WO2021129403A1 true WO2021129403A1 (fr) 2021-07-01

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CN (1) CN111135381A (fr)
WO (1) WO2021129403A1 (fr)

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* Cited by examiner, † Cited by third party
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CN112618857A (zh) * 2020-12-10 2021-04-09 微泰医疗器械(杭州)股份有限公司 组装式的柔性电路板及其制造方法和给药装置
US20240115799A1 (en) * 2021-01-05 2024-04-11 Medtrum Technologies Inc. Skin patch drug infusion device
CN113786533A (zh) * 2021-09-30 2021-12-14 北京伏尔特技术有限公司 胰岛素泵用胰岛素输注控制方法、***以及胰岛素泵
CN114306904A (zh) * 2021-12-30 2022-04-12 山东丝琳医药科技有限公司 药物导入仪
CN115886925B (zh) * 2023-01-09 2023-05-02 苏州英途康医疗科技有限公司 一种智能施夹器

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WO2013099123A1 (fr) * 2011-12-26 2013-07-04 パナソニック株式会社 Dispositif d'injection de médicament
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