WO2021115084A1 - 一种基于结构磁共振影像的大脑年龄深度学习预测*** - Google Patents
一种基于结构磁共振影像的大脑年龄深度学习预测*** Download PDFInfo
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- A61B5/0042—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part for the brain
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- A61B2576/026—Medical imaging apparatus involving image processing or analysis specially adapted for a particular organ or body part for the brain
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- the present invention relates to the field of computer and neuroscience, in particular to a brain age prediction system based on structural magnetic resonance images.
- Artificial intelligence methods can build a predictive model of brain aging by using magnetic resonance images of the brain structure to predict the age of the elderly.
- the age predicted by the model is called "brain age".
- the age of the brain can indicate the current aging stage of the brain and even predict the risk of related diseases in the future.
- the prediction model established by the image data of healthy elderly actually describes a normal elderly brain aging trajectory, and the difference between the age of the brain and its true age can reflect the degree to which a person deviates from the aging trajectory of the healthy brain.
- the degree of early or late aging of the brain It has been proven that the greater the difference between the brain age of the elderly and the real age, the higher the risk of mental or physical problems and the more likely to die early. In clinical practice, doctors can use this indicator to assess the degree of brain aging in the elderly and take corresponding intervention measures.
- the method of predicting the age of the brain with structural magnetic resonance images is mainly based on traditional machine learning methods.
- a large amount of preprocessing and feature extraction are required for the MRI images of the brain structure.
- the features commonly used for brain age prediction include: Gray Matter Density Map (GMD), White Matter Density Map (WMD), White Matter Volume, Cortical Thickness, Network Feature Parameters, etc.
- the extracted feature dimensions may range from tens of dimensions to hundreds of dimensions. Therefore, in the process of using traditional machine learning methods to establish a brain age prediction model, it is often necessary to perform feature selection or feature dimensionality reduction steps.
- GMD-based models can be used to predict brain age, but because GMD-based models have the disadvantage of high feature dimensions, the constructed models are prone to overfitting and poor generalization ability.
- extraction of image features is easily affected by many factors. For example, optional parameters such as image smoothing and voxel size are involved in the process of GMD feature generation. These parameters have a great impact on the results of feature extraction and even brain age prediction. influences.
- convolutional neural networks are being tried to predict the age of the brain, but unlike natural images, structural magnetic resonance imaging is a three-dimensional image, and the training sample size is much smaller than natural images, so this is very important for convolutional neural network structures.
- the structure of MRI presents a higher challenge, requiring the convolutional neural network to fully extract and utilize the information contained in the magnetic resonance image.
- the current convolutional neural networks applied to the brain age prediction task are too traditional and only use the structure of convolution + pooling + full connection, and the efficiency of feature extraction and utilization needs to be improved.
- the purpose of the present invention is to provide a brain age prediction system based on structured magnetic resonance images, which predicts the brain age of the elderly based on structured magnetic resonance images through convolutional neural networks.
- the present invention regards the convolutional network as a high-dimensional feature extractor, and performs hierarchical characterization and description of the feature information of the magnetic resonance image of the complex brain structure, first expresses the underlying features, and then combines these low-level features to obtain a more detailed Rich high-level features are expressed, and effective features are efficiently extracted to evaluate the current aging stage of the brain, that is, "brain age”.
- the present invention proposes an AGE-DenseNet network structure on the basis of a traditional convolutional network, which can greatly improve the utilization efficiency of features and obtain an excellent brain age prediction effect.
- the invention has fast analysis speed, strong generalization ability, practicability and ease of use.
- the present invention provides a brain age deep learning prediction system based on structural magnetic resonance images, including:
- the training set building module is used to construct the training set using the original structure magnetic resonance images from different sources;
- the data preprocessing module is used to perform preprocessing operations on the magnetic resonance images of each original structure.
- the preprocessing operations include image registration, skull stripping and image data standardization;
- the deep learning model building module is used to build a convolutional neural network model AGE-DenseNet based on the Keras framework and the DenseNet idea;
- the deep learning model training module is used to use the constructed training set to perform supervised learning on the constructed convolutional neural network model AGE-DenseNet through back propagation and gradient descent algorithms;
- the brain age prediction module is used to send the preprocessed MRI image of the original structure to the convolutional neural network model AGE-DenseNet to predict the age of the brain, obtain the predicted value of the brain age, and calculate the predicted value of the brain age and the actual age The difference between, assess the degree of brain aging.
- the convolutional neural network model AGE-DenseNet includes five repeated convolution blocks, and each convolution block includes two identical convolution units and a 2 ⁇ 2 ⁇ 2 maximum pooling layer with a step size of 2.
- Each convolution unit includes a 3 ⁇ 3 ⁇ 3 convolution layer with a step length of 1, a ReLU activation and a 3D batch normalization layer,
- the maximum pooling method When learning and training, use the maximum pooling method to downsample the feature maps output by each convolution block, change its size, and then concatenate it with the feature maps output by other convolution blocks into a single tensor as the current The input of the convolution block; and after the last convolution block, the global average pooling layer (Global average pooling) is used to vectorize the feature map into a feature vector.
- the global average pooling layer (Global average pooling) is used to vectorize the feature map into a feature vector.
- a unary fully connected layer plus the ReLU activation function is used to map the feature vector obtained by the global average pooling to a single output value.
- the image registration includes performing a non-linear registration operation on the original structure magnetic resonance image
- the skull dissection includes acquiring a registered structural magnetic resonance image of the skull dissection image through a preset threshold;
- the image data normalization includes calculating the average value and standard deviation of the voxels in the brain contour after skull stripping, and performing Gaussian normalization on the voxels in the brain contour.
- the present invention has the following advantages:
- the present invention adopts the convolutional neural network structure based on DenseNet idea-AGE-DenseNet. Compared with the traditional machine learning prediction model, the present invention can directly analyze and process the whole brain structure magnetic resonance image without manually extracting the structural features of the brain (such as gray density map, white matter density map, white matter volume, cortical thickness, etc.). It can avoid the tedious process of feature extraction and feature selection/dimensionality reduction.
- the present invention adopts a "convolution + dense connection (Dense connection) + global average pooling" structure in the deep learning model design process, that is, adding between convolutional layers
- the tight short-circuit connection can effectively improve the utilization efficiency of features, and obviously alleviate the problem of gradient disappearance during the gradient backpropagation process.
- the global average pooling layer is used to replace the traditional fully connected layer, which saves more space At the same time of information, it slows down the phenomenon of over-fitting to a certain extent.
- the present invention can accurately, efficiently and quickly predict the age of the brain of the elderly through the magnetic resonance imaging of the brain structure, and quantify the degree of deviation of the brain from the aging track of the healthy brain, especially for the early diagnosis and prevention of diseases of the elderly. Provide an important basis.
- Figure 1 is a flow chart of the brain age prediction method based on structured magnetic resonance imaging of the present invention
- Figure 2 is a structural diagram of the convolutional neural network model AGE-DenseNet of the present invention.
- FIG. 3 is a schematic diagram of deep learning prediction of brain age based on structural magnetic resonance images according to an embodiment of the present invention.
- Brain aging is a universal biological phenomenon that appears with age, which can lead to subtle changes in the structure of the brain. Even healthy elderly people will have a certain degree of decline in their cognitive ability as they age, and the risk of disease will increase accordingly. This is a normal aging trajectory. However, some people deviate from this normal aging trajectory due to genes, environment, or disease.
- the present invention aims to quantify the early or delayed aging of the brain, and use this to predict the future development trajectory of individuals and the subsequent The risk of aging-related health deterioration.
- the present invention will be further described below in conjunction with the accompanying drawings and embodiments. It should be understood that the embodiments described below are intended to facilitate the understanding of the present invention and do not have any limiting effect on it.
- the present invention is preferentially applicable to MRI images of brain structures that have undergone non-linear registration and skull stripping, and the preprocessing process uses the FSL5.0 fsl_anat command.
- the present invention first preprocesses the image to meet the input requirements of the convolutional neural network model AGE-DenseNet of the present invention, such as image size, etc.; and then convolves and pools the image through the convolutional neural network model AGE-DenseNet And other feature extraction operations; finally, the extracted high-dimensional features are fused to obtain the predicted brain age.
- the method for predicting brain age based on structural magnetic resonance imaging of the present invention includes the following steps:
- the original input image is a T1 magnetic resonance image of the brain.
- the preprocessing operations include image non-linear registration, skull stripping, and image data normalization.
- image registration includes: performing a non-linear registration operation on the input image; skull peeling includes: obtaining a skull peeled image of the registered T1 image through a preset threshold; image data standardization includes: calculating the skull peeling For the average value and standard deviation of voxels in the brain contour, Gaussian normalization is performed on the voxels in the brain contour, and then the background outside the brain contour is set to 0.
- Preprocessing the original input image can improve the prediction accuracy of the depth method to predict the age of the brain on the one hand, and accelerate the processing and analysis speed on the other hand, with high efficiency and ease of use.
- the convolutional neural network architecture of the present invention uses fixed-size magnetic resonance image data of the three-dimensional brain T1 structure as input.
- This CNN architecture contains five repeated Convolutional Blocks, and each Convolutional Block contains two identical Convolutional Units and a 2 ⁇ 2 ⁇ 2 maximum pooling layer with a step size of 2.
- the convolution unit includes a 3 ⁇ 3 ⁇ 3 convolution layer with a step length of 1, a ReLU activation and a 3D batch normalization layer.
- the number of feature channels is set to 8, and it is doubled after entering the next convolution block to infer a sufficiently rich representation of brain information.
- the present invention is based on DenseNet, which connects the feature maps learned by different convolution blocks in series, increases the input variables of subsequent layers, and improves the feature utilization efficiency and learning of the network. effect.
- DenseNet which connects the feature maps learned by different convolution blocks in series, increases the input variables of subsequent layers, and improves the feature utilization efficiency and learning of the network. effect.
- Each convolution block will integrate all the previous convolution block output feature mapping information as input. Since the size of the output feature maps of different convolution blocks is different, first use the maximum pooling method to downsample the feature maps, change their size, and then concatenate them with the feature maps output by other convolution blocks into a single The tensor of is used as the input of the current convolution block.
- the global average pooling layer (Global average pooling) is used to vectorize the feature map into a feature vector.
- the final age prediction is to use a unary fully connected layer plus the ReLU activation function, which maps the feature vector obtained by the global average pooling to a single output value.
- the structure of the convolutional neural network model AGE-DenseNet of the present invention is shown in FIG. 2.
- S4 Use the training set to train and learn the constructed convolutional neural network model AGE-DenseNet through backpropagation and gradient descent algorithms, and select a model with high prediction accuracy and strong generalization performance for storage, which is convenient for users to call.
- S5 Use the cross-validation method to verify the convolutional neural network model AGE-DenseNet, and adjust the hyperparameters in the training of the convolutional neural network model AGE-DenseNet.
- S6 Send the MRI image of the original structure after the preprocessing operation to the convolutional neural network model AGE-DenseNet, which is verified to be accurate, to predict the age of the brain, obtain the predicted value of the brain age, and calculate the difference between the predicted value of the brain age and the actual age. Assess how far the current brain deviates from the aging trajectory of a healthy brain.
- the skull in the registered image is stripped, and only the brain tissue is retained;
- this scheme first obtains the rough brain contour by setting the threshold, and then calculates the average and standard deviation of the voxels in the brain contour. Gaussian normalization of brain voxels;
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Abstract
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Claims (8)
- 一种基于结构磁共振影像的大脑年龄深度学习预测***,其特征在于,包括:训练集构建模块,用于利用不同来源的原始结构磁共振影像构建训练集;数据预处理模块,用于对各原始结构磁共振影像进行预处理操作,预处理操作包括图像配准、头骨剥离以及图像数据标准化;深度学习模型构建模块,用于利用Keras框架以及基于DenseNet思想,构建卷积神经网络模型AGE-DenseNet;深度学习模型训练模块,用于利用所构建的训练集,通过反向传播和梯度下降算法对构建的卷积神经网络模型AGE-DenseNet进行监督学习;模型验证模块,用于利用交叉验证的方法对卷积神经网络模型AGE-DenseNet进行验证,调整卷积神经网络模型AGE-DenseNet训练中的超参数;大脑年龄预测模块,用于将预处理操作后的原始结构磁共振影像送入验证准确的卷积神经网络模型AGE-DenseNet进行大脑年龄预测,得到大脑年龄预测值,计算大脑年龄预测值与实际年龄的差值,评估大脑衰老程度。
- 根据权利要求1所述的***,其特征在于,所述卷积神经网络模型AGE-DenseNet包括五个重复的卷积块,各卷积块包括两个完全相同的卷积单元和一个步长为2的2×2×2最大池化层,各卷积单元包括步长为1的3×3×3卷积层、一个ReLU激活以及一个3D批标准化层;学***均池化层,将特征映射矢量化为一个特征向量;大脑年龄预测时,使用一个一元全连接层加上ReLU激活函数,将全局平均池化得到的特征向量映射到一个单独的输出值。
- 根据权利要求1或2所述的***,其特征在于,所述图像配准包括将原始结构磁共振影像执行非线性配准操作;所述头骨剥离包括通过预先设定阈值获取已配准后的结构磁共振影 像的头骨剥离图像;所述图像数据标准化包括计算经过头骨剥离后的大脑轮廓内体素的平均值和标准差,将大脑轮廓内体素进行高斯标准化。
- 一种基于结构磁共振影像的大脑年龄预测方法,其特征在于,包括:构建原始输入图像;所述原始输入图像为大脑磁共振影像;根据所述原始输入图像构建训练集;构建卷积神经网络模型;利用所述训练集,通过反向传播和梯度下降算法对构建的卷积神经网络模型进行训练,得到训练好的模型;将待预测的大脑磁共振影像输入所述训练好的模型,得到大脑年龄预测值。
- 根据权利要求4所述的基于结构磁共振影像的大脑年龄预测方法,其特征在于,所述根据所述原始输入图像构建训练集,具体包括:将所述原始输入图像执行非线性配准操作;通过预先设定阈值对已配准后的图像进行头骨剥离,得到头骨剥离图像;计算头骨剥离图像的大脑轮廓内体素的平均值和标准差,将大脑轮廓内体素进行高斯标准化,再将大脑轮廓外背景设置为0,得到图像数据标准化的结果;根据图像数据标准化的结果构建训练集。
- 根据权利要求4所述的基于结构磁共振影像的大脑年龄预测方法,其特征在于,所述卷积神经网络模型的架构包含五个重复的卷积块,每个卷积块包含两个完全相同的卷积单元和一个步长为2的2×2×2最大池化层;每个卷积单元包含步长为1的3×3×3卷积层、一个ReLU激活以及一个3D批标准化层;不同卷积块学习到的特征映射基于DenseNe串联。
- 根据权利要求4所述的基于结构磁共振影像的大脑年龄预测方法,其特征在于,所述利用所述训练集,通过反向传播和梯度下降算法对构建的卷积神经网络模型进行训练,得到训练好的模型,具体包括:利用所述训练集,通过反向传播和梯度下降算法对构建的卷积神经网络模型进行训练;利用交叉验证的方法对每次训练后的卷积神经网络模型进行验证,调整所述卷积神经网络模型训练中的超参数,进入下一次训练;当到达训练停止条件时,得到训练好的模型。
- 根据权利要求4所述的基于结构磁共振影像的大脑年龄预测方法,其特征在于,所述将待预测的大脑磁共振影像输入所述训练好的模型,得到大脑年龄预测值,之后还包括:计算大脑年龄预测值与实际年龄的差值,评估当前大脑偏离健康大脑衰老轨迹的程度。
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