WO2021111311A3 - 국소 부착 키나아제 저해제로서 신규한 아다만탄 유도체 - Google Patents

국소 부착 키나아제 저해제로서 신규한 아다만탄 유도체 Download PDF

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Publication number
WO2021111311A3
WO2021111311A3 PCT/IB2020/061350 IB2020061350W WO2021111311A3 WO 2021111311 A3 WO2021111311 A3 WO 2021111311A3 IB 2020061350 W IB2020061350 W IB 2020061350W WO 2021111311 A3 WO2021111311 A3 WO 2021111311A3
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WO
WIPO (PCT)
Prior art keywords
inhibitors
focal adhesion
adhesion kinase
adamantane derivatives
novel adamantane
Prior art date
Application number
PCT/IB2020/061350
Other languages
English (en)
French (fr)
Other versions
WO2021111311A2 (ko
Inventor
기민효
권호석
이영훈
송은선
박용빈
이국화
조형민
안순길
홍성표
김성혜
Original Assignee
삼진제약주식회사
인천대학교 산학협력단
주식회사 바미켐
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 삼진제약주식회사, 인천대학교 산학협력단, 주식회사 바미켐 filed Critical 삼진제약주식회사
Priority to JP2022532125A priority Critical patent/JP7390487B2/ja
Priority to EP20895884.3A priority patent/EP4074697A4/en
Priority to CN202080082764.3A priority patent/CN114929675B/zh
Priority to US17/782,117 priority patent/US20230049557A1/en
Publication of WO2021111311A2 publication Critical patent/WO2021111311A2/ko
Publication of WO2021111311A3 publication Critical patent/WO2021111311A3/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

본 발명은 국소 부착 키나아제 저해제로서 신규한 아다만탄 유도체, 이의 약학적으로 허용 가능한 염, 이의 입체 이성질체, 이의 수화물 또는 용매화물 및 이를 포함하는 포함하는 약학적 조성물을 제공한다.
PCT/IB2020/061350 2019-12-03 2020-12-02 국소 부착 키나아제 저해제로서 신규한 아다만탄 유도체 WO2021111311A2 (ko)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2022532125A JP7390487B2 (ja) 2019-12-03 2020-12-02 焦点接着キナーゼ阻害剤としての新規なアダマンタン誘導体
EP20895884.3A EP4074697A4 (en) 2019-12-03 2020-12-02 NOVEL ADAMANTANE DERIVATIVES AS FOCAL ADHESION KINASE INHIBITORS
CN202080082764.3A CN114929675B (zh) 2019-12-03 2020-12-02 作为粘着斑激酶抑制剂的新型金刚烷衍生物
US17/782,117 US20230049557A1 (en) 2019-12-03 2020-12-02 Novel adamantane derivatives as inhibitors of focal adhesion kinase

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2019-0159011 2019-12-03
KR20190159011 2019-12-03

Publications (2)

Publication Number Publication Date
WO2021111311A2 WO2021111311A2 (ko) 2021-06-10
WO2021111311A3 true WO2021111311A3 (ko) 2021-07-22

Family

ID=76221516

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2020/061350 WO2021111311A2 (ko) 2019-12-03 2020-12-02 국소 부착 키나아제 저해제로서 신규한 아다만탄 유도체

Country Status (6)

Country Link
US (1) US20230049557A1 (ko)
EP (1) EP4074697A4 (ko)
JP (1) JP7390487B2 (ko)
KR (1) KR102472103B1 (ko)
CN (1) CN114929675B (ko)
WO (1) WO2021111311A2 (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112341406B (zh) * 2020-11-18 2023-02-10 韶远科技（上海)有限公司 反式-4-[4-(3-甲氧基-4-硝基苯基)-1-哌嗪基]金刚烷-1-醇合成方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001047897A1 (en) * 1999-12-28 2001-07-05 Pharmacopeia, Inc. Cytokine, especially tnf-alpha, inhibitors
WO2003018022A1 (en) * 2001-08-22 2003-03-06 Amgen Inc. 2-amino-4-heteroarylaminopyrimidine derivatives for use in the treatment of cancer
WO2003026666A1 (en) * 2001-09-26 2003-04-03 Bayer Pharmaceuticals Corporation 2-phenylamino-4- (5-pyrazolylamino)-pyrimidine derivatives as kinase inhibitors, in particular, as src kinase inhibitors
WO2005016894A1 (en) * 2003-08-15 2005-02-24 Novartis Ag 2, 4-pyrimidinediamines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders
CN106905303A (zh) * 2017-03-16 2017-06-30 北京师范大学 一类靶向fak的化合物和其标记物、及它们的制备方法和应用

Family Cites Families (9)

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GB0305929D0 (en) * 2003-03-14 2003-04-23 Novartis Ag Organic compounds
KR20080110998A (ko) 2006-01-30 2008-12-22 엑셀리시스, 인코포레이티드 Ｊａｋ­２ 조절자로서 ４­아릴­２­아미노­피리미딘 또는 4­아릴­２­아미노알킬­피리미딘 및 이들을 포함하는 약제학적 조성물
AU2007333394C1 (en) * 2006-12-08 2011-08-18 Novartis Ag Compounds and compositions as protein kinase inhibitors
WO2012120051A1 (de) 2011-03-08 2012-09-13 Sanofi Mit adamantan- oder noradamantan substituierte benzyl-oxathiazinderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
CN106883213B (zh) * 2015-12-15 2021-04-20 合肥中科普瑞昇生物医药科技有限公司 一种egfr和alk激酶的双重抑制剂
TWI772291B (zh) * 2016-03-25 2022-08-01 大陸商正大天晴藥業集團股份有限公司 取代的吡咯並嘧啶類ｃｄｋ抑制劑、包含其藥物組合物及其用途
EP3544970B1 (en) * 2016-11-22 2021-11-17 Dana-Farber Cancer Institute, Inc. Inhibitors of interleukin-1 receptor-associated kinases and uses thereof
GB201708456D0 (en) 2017-05-26 2017-07-12 Medical Res Council Senolytic compounds
KR102163494B1 (ko) * 2018-10-26 2020-10-08 한국과학기술연구원 단백질 키나아제 저해제인 헤테로방향족 매크로시클릭 유도체

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001047897A1 (en) * 1999-12-28 2001-07-05 Pharmacopeia, Inc. Cytokine, especially tnf-alpha, inhibitors
WO2003018022A1 (en) * 2001-08-22 2003-03-06 Amgen Inc. 2-amino-4-heteroarylaminopyrimidine derivatives for use in the treatment of cancer
WO2003026666A1 (en) * 2001-09-26 2003-04-03 Bayer Pharmaceuticals Corporation 2-phenylamino-4- (5-pyrazolylamino)-pyrimidine derivatives as kinase inhibitors, in particular, as src kinase inhibitors
WO2005016894A1 (en) * 2003-08-15 2005-02-24 Novartis Ag 2, 4-pyrimidinediamines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders
CN106905303A (zh) * 2017-03-16 2017-06-30 北京师范大学 一类靶向fak的化合物和其标记物、及它们的制备方法和应用

Also Published As

Publication number Publication date
KR20210069585A (ko) 2021-06-11
JP2023504468A (ja) 2023-02-03
US20230049557A1 (en) 2023-02-16
CN114929675B (zh) 2024-02-13
WO2021111311A2 (ko) 2021-06-10
KR102472103B1 (ko) 2022-11-29
EP4074697A2 (en) 2022-10-19
JP7390487B2 (ja) 2023-12-01
CN114929675A (zh) 2022-08-19
EP4074697A4 (en) 2024-01-03

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