WO2021057828A1 - 照射参数选取装置及其使用方法、含该装置的控制***及其使用方法 - Google Patents
照射参数选取装置及其使用方法、含该装置的控制***及其使用方法 Download PDFInfo
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- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/103—Treatment planning systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/103—Treatment planning systems
- A61N5/1039—Treatment planning systems using functional images, e.g. PET or MRI
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1085—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy characterised by the type of particles applied to the patient
- A61N2005/109—Neutrons
Definitions
- the present invention relates to the field of radiotherapy, in particular to an irradiation parameter selection device and its use method, a control system containing the device and its use method.
- radiotherapy such as cobalt sixty, linear accelerator, and electron beam has become one of the main methods of cancer treatment.
- traditional photon or electron therapy is limited by the physical conditions of radiation itself. While killing tumor cells, it will also cause damage to a large number of normal tissues along the beam path.
- traditional radiotherapy For more radiation-resistant malignant tumors (such as: glioblastoma multiforme, melanoma), the treatment effect is often poor.
- neutron capture therapy is a combination of the above two concepts, such as Boron Neutron Capture Therapy (BNCT), through the specific aggregation of boron-containing drugs in tumor cells, and precise beam control, providing A better cancer treatment option than traditional radiation.
- BNCT Boron Neutron Capture Therapy
- Boron neutron capture therapy uses boron-containing ( 10 B) drugs to have a high capture cross section for thermal neutrons.
- the 10 B(n, ⁇ ) 7 Li neutron capture and nuclear fission reactions produce 4 He and 7 Li. Heavily charged particles.
- the total range of the two particles is about the size of a cell. Therefore, the radiation damage to organisms can be limited to the cell level.
- boron-containing drugs are selectively aggregated in tumor cells, with an appropriate neutron source , It can achieve the purpose of killing tumor cells locally without causing too much damage to normal tissues.
- the irradiation geometric angle is manually judged and defined based on experience. Due to the complex structure of the human body, the sensitivity of various tissues or organs to radiation is also very different, so relying solely on manual judgment is likely to ignore the better irradiation angle, which will result in a greatly reduced treatment effect. With the development of technology, software has been used to calculate the evaluation values of several different illumination angles and the best illumination point and illumination angle are selected accordingly. However, the best illumination point and illumination angle selected by the software calculation result are the theoretically best. Good, there is the possibility of impossible implementation in the actual operation process. In order to achieve the optimization of the treatment effect and the implementability of the treatment plan, the selection of the irradiation point and the irradiation angle of the beam needs to be further optimized.
- the positioning process of the mounting table needs to be further optimized.
- an irradiation parameter selection device capable of selecting the best feasible irradiation point and irradiation angle.
- the irradiation parameter includes the irradiation point and the irradiation angle.
- the irradiation parameter The selection device includes: a sampling part, which selects multiple sets of irradiation points and irradiation angles; a calculation part, which calculates the evaluation value corresponding to each group of irradiation points and irradiation angles; Select a group of best practicable irradiation points and irradiation angles from the irradiation point and irradiation angle.
- the calculation unit calculates the depth of incidence of the neutron beam after entering the patient and the type of organ that it passes through, and then determines whether the tumor falls on the group of irradiation points and irradiation angles based on the track information of the neutron beam passing through the human body Corresponding to the maximum treatable depth range, if yes, use the track information as the basis to calculate the group of irradiation points and irradiation angle corresponding to the data of the organ boron concentration, organ radiation sensitivity factor and neutron beam characteristic information set by the user The evaluation value.
- the optimal selection part eliminates the irradiation points and irradiation angles that cannot be implemented in the actual irradiation process from all the sampled irradiation points and irradiation angles, and selects a set of optimal irradiation points and irradiation angles that can be implemented.
- Another aspect of the present application also provides a method for using the above-mentioned irradiation parameter selection device, which includes the following steps: the sampling part reads the patient's images with clear human anatomy such as CT or MRI or PET-CT, and defines each organ and tissue one by one. And the contour of the tumor, and for the set material type and density, after completing the definition of the contour, material and density, select the irradiation point and the irradiation angle of the neutron beam; the calculation part calculates the track of the organ through which the neutron beam passes , That is, calculate the type and thickness of the organ that the neutron beam passes through after entering the human body.
- This track information is based on combining the information of the organ boron concentration, organ radiation sensitivity factor and neutron beam characteristics set by the user to calculate the evaluation value corresponding to the irradiation point and the irradiation angle; if not, the worst evaluation value is given , After completing the calculation of the evaluation value, record the irradiation point, the irradiation angle and the corresponding evaluation value; the selection department selects a set of optimal and implementable irradiation parameters from all the sampled irradiation parameters.
- the selection of the irradiation point and the irradiation angle can be forward selection or reverse selection.
- the forward selection determines the position of the irradiation point outside the human body and can be sampled sequentially according to a fixed angle or distance interval, or Sampling is performed by random sampling; inverse selection is to determine the irradiation point within the tumor range.
- the irradiation point can be the center of mass or the deepest part of the tumor, and the irradiation angle can be randomly sampled or sampled at a predetermined interval angle. Proceed; the neutron beam angle can be set to the vector direction from the irradiation point to the center of mass of the tumor or the deepest part of the tumor.
- the optimal selection unit After the optimal selection unit ranks the pros and cons of each group of irradiation points and angles, it verifies whether each group of irradiation points and angles can be implemented in order from the best to the worst, until it finds a set of the best that can be implemented. Excellent irradiation point and angle.
- the preferential selection unit first finds out all the unimplementable irradiation points and irradiation angles, and then eliminates these unimplementable irradiation points and irradiation angles, and finally, in the remaining irradiation points and irradiation angles. Choose the best set of angles.
- the optimal selection unit precludes irradiation points and irradiation angles that cannot be implemented, and then selects the optimal group after the calculation is completed.
- the calculation unit outputs the data of the irradiation point, the irradiation angle, and the corresponding evaluation value in the form of a 3D or 2D image.
- the selection process of the selection unit may be performed automatically by related equipment, or may be partially interspersed with manual operation.
- a third aspect of the present application provides a control system that can quickly adjust the placement table in place, the control system is used to control the neutron capture treatment equipment, the neutron capture treatment equipment includes the placement table for placing the patient, so
- the control system includes: an irradiation parameter selection device for selecting the best irradiation point and irradiation angle that can be implemented; a conversion part that converts the parameters of the best irradiation point and irradiation angle that can be implemented into coordinate parameters that the stage needs to move into place ; And the adjustment part to adjust the stage to the coordinate position obtained from the conversion part.
- the irradiation parameter selection device includes a sampling part, a calculation part and a selection part.
- the sampling part selects multiple sets of irradiation points and irradiation angles
- the calculation part calculates the evaluation value corresponding to each group of irradiation points and irradiation angles,
- the optimal selection unit selects a set of best feasible irradiation points and irradiation angles from all the sampled irradiation points and irradiation angles.
- the conversion unit combines the patient's CT/MRI/PET-CT information, positioning information, structural information of the mounting table, etc., to convert the parameters of the best irradiation point and irradiation angle that can be implemented into the mounting table during the irradiation process The coordinate parameters that need to be moved into place.
- the fourth aspect of the present application provides a method for using the above-mentioned control system, which includes the following steps: the irradiation parameter selection device selects the best irradiation point and the irradiation angle that can be implemented; the conversion part changes the parameters of the best irradiation point and the irradiation angle that can be implemented Converted into coordinate parameters that the stage needs to move into place; the adjustment part adjusts the stage to the coordinate position obtained from the conversion part.
- the irradiation parameter selection device includes a sampling part, a calculation part, and a selection part.
- the method of using the irradiation parameter selection device is as follows: First, the sampling part selects multiple sets of irradiation points and irradiation angles, and then the calculation part calculates The evaluation value corresponding to each group of irradiation points and irradiation angles, and then the optimal selection unit selects a set of best feasible irradiation points and irradiation angles from all the sampled irradiation points and irradiation angles according to the evaluation value calculated by the calculation unit.
- the neutron capture treatment equipment uses neutron beams to irradiate the patient to achieve treatment, and the sampling unit reads the patient’s CT/MRI/PET-CT and other images with clear human anatomy, and defines the status of each organ, tissue, and tumor one by one. Contour, and for the set material type and density, after completing the definition of the contour, material and density, select multiple groups of neutron beam irradiation points and irradiation angles.
- the calculation unit calculates the track of the patient's organ through which the neutron beam passes, that is, calculates the type and thickness of the organ that the neutron beam passes through after entering the human body, and obtains the track of the neutron beam through the human body. After information, it is determined whether the tumor falls within the maximum treatable depth range. If so, the track information is used as the basis to combine the organ boron concentration, organ radiation sensitivity factor and neutron beam characteristics set by the user to calculate the The evaluation value corresponding to the irradiation point and the irradiation angle; if not, the worst evaluation value is given. After the calculation of the evaluation value is completed, each group of irradiation points and irradiation angles and their corresponding evaluation values are recorded.
- the calculation unit outputs the data of each group of irradiation points and irradiation angles and their corresponding evaluation values in the form of 3D or 2D images.
- the optimal selection unit After the optimal selection unit ranks the pros and cons of each group of irradiation points and angles, it verifies whether each group of irradiation points and angles can be implemented in order from the best to the worst, until it finds a set of the best that can be implemented. Excellent irradiation point and angle.
- the prioritization unit first finds out all unimplementable irradiation points and irradiation angles, and then eliminates these unimplementable irradiation points and irradiation angles, and finally, selects the optimal group from the remaining irradiation points and irradiation angles .
- the fifth aspect of the present application provides a neutron capture treatment device capable of judging the pros and cons of the irradiation point and the irradiation angle, which includes: a neutron beam generating assembly, an irradiation room for irradiating a neutron beam to an irradiated body, A management room for implementing irradiation control, a placing table for placing patients, and a control system for controlling and managing the treatment process, the control system including an irradiation parameter selection device for selecting the optimal irradiation point and irradiation angle,
- the irradiation parameter selection device includes a sampling part and a calculation part. The sampling part selects multiple groups of irradiation points and irradiation angles.
- the calculation part calculates the evaluation values corresponding to each group of irradiation points and irradiation angles and outputs a report.
- the calculation unit calculates the depth of incidence of the neutron beam after entering the patient and the type of organ that it passes through, and then determines whether the tumor falls on the group of irradiation points and irradiation angles based on the track information of the neutron beam passing through the human body Corresponding to the maximum treatable depth range, if yes, use the track information as the basis to calculate the group of irradiation points and irradiation angle corresponding to the data of the organ boron concentration, organ radiation sensitivity factor and neutron beam characteristic information set by the user If not, give the worst evaluation value.
- the calculation unit outputs the data of the irradiation point, the irradiation angle and the corresponding evaluation value in the form of a 3D or 2D image.
- weighting factor (W(i)) of organ i corresponding to a certain irradiation point and irradiation angle and a certain irradiation track is calculated using formula 1:
- I(i), S(i) and C(i) are the neutron intensity, the radiation sensitivity factor of organ i, and the boron concentration of organ i, respectively.
- I(i) is calculated by using formula 2 which simulates the depth intensity of the human body or the integral of the dose curve according to the beam used:
- i(x) is the depth intensity or dose curve function of the therapeutic beam in the approximate human body
- x0-x is the depth range of the organ (i) in the beam track.
- Q (x, y, z, ⁇ , ⁇ ) as the evaluation factor is equal to the sum of the weight factors of each organ in the organ track.
- the ratio of the evaluation factor to the tumor evaluation factor (QR(x,y,z, ⁇ , ⁇ )) is calculated using formula 4:
- W tumor is the weighting factor of tumor.
- the sixth aspect of the present application provides a method for using the above-mentioned irradiation parameter selection device, which includes the following steps: a sampling part reads a patient such as CT or MRI or PET-CT with a clear human anatomy image, and defines the contours of each organ, tissue and tumor one by one , And for the set material type and density, after completing the definition of the contour, material and density, select the irradiation point and irradiation angle of the neutron beam; the calculation part calculates the track of the organ through which the neutron beam passes, that is, it calculates The type and thickness of the organ that the neutron beam passes through after entering the human body.
- the track information After obtaining the track information of the neutron beam passing through the human body, it is determined whether the tumor falls within the maximum treatable depth range, and if so, the track information is used In order to calculate the evaluation value corresponding to the irradiation point and the irradiation angle based on the information of the organ boron concentration, the organ radiation sensitivity factor and the neutron beam characteristics set by the user; if not, a special evaluation value is given to complete the evaluation value After the calculation, record the irradiation point, irradiation angle and corresponding evaluation value.
- the selection of the irradiation point and the irradiation angle can be forward selection or reverse selection.
- the forward selection determines the position of the irradiation point outside the human body and can be sampled sequentially according to a fixed angle or distance interval, or Sampling is performed by random sampling; inverse selection is to determine the irradiation point within the tumor range.
- the irradiation point can be the center of mass or the deepest part of the tumor, and the irradiation angle can be randomly sampled or sampled at a predetermined interval angle. Proceed; the neutron beam angle can be set to the vector direction from the irradiation point to the center of mass of the tumor or the deepest part of the tumor.
- the calculation unit outputs the data of the irradiation point, the irradiation angle and the corresponding evaluation value in the form of a 3D or 2D image.
- Figure 1 is a schematic diagram of the boron neutron capture reaction.
- Figure 2 is the 10 B(n, ⁇ ) 7 Li neutron capture nuclear reaction equation.
- Fig. 3 is a schematic diagram of a neutron capture treatment device in an embodiment of the present invention.
- Fig. 4 is a schematic diagram of a control system in an embodiment of the present invention.
- Fig. 5 is a logical block diagram of the calculation of the evaluation value of the irradiation parameter of the neutron beam in the embodiment of the present invention.
- Fig. 6 is a schematic diagram of organ tracks during neutron beam irradiation in an embodiment of the present invention.
- boron neutron capture therapy is the most common, and the neutrons for boron neutron capture therapy can be supplied by nuclear reactors or accelerators.
- Boron Neutron Capture Therapy is the use of boron-containing ( 10 B) drugs to have high thermal neutron capture cross-section characteristics, through 10 B (n, ⁇ ) 7 Li neutron capture and nuclear fission reaction Two types of heavily charged particles, 4 He and 7 Li, are produced. 1 and 2, which respectively show the schematic diagram of the boron neutron capture reaction and the 10 B(n, ⁇ ) 7 Li neutron capture nuclear reaction equation.
- the average energy of the two heavily charged particles is about 2.33 MeV, which has a high Linear Energy Transfer (LET) and short-range characteristics.
- the linear energy and range of ⁇ particles are 150keV/ ⁇ m and 8 ⁇ m, respectively, while the 7 Li heavy-load particles are 175keV/ ⁇ m and 5 ⁇ m.
- the total range of the two particles is approximately It is equivalent to the size of a cell, so the radiation damage to organisms can be limited to the cell level.
- boron-containing drugs selectively accumulate in tumor cells, with an appropriate neutron radiation source, they can accurately kill tumor cells without causing too much damage to normal tissues.
- the resulting mixed radiation field that is, the beam contains low to high energy neutrons and photons; for deep tumors, boron neutrons
- the human head tissue prosthesis is used to calculate the dose distribution, and the prosthetic beam quality factor is used as the medium. Design reference for sub-beams.
- the International Atomic Energy Agency has given five recommendations for air beam quality factors for neutron sources used in clinical boron neutron capture therapy. These five recommendations can be used to compare the pros and cons of different neutron sources and serve as Reference basis for selecting neutron generation methods and designing beam shaping bodies. The five recommendations are as follows:
- Thermal neutron to epithermal neutron flux ratio thermal to epithermal neutron flux ratio ⁇ 0.05
- the energy range of superthermal neutrons is between 0.5eV and 40keV, the energy range of thermal neutrons is less than 0.5eV, and the energy range of fast neutrons is greater than 40keV.
- the neutron beam flux and the concentration of boron-containing drugs in the tumor jointly determine the clinical treatment time. If the concentration of the boron-containing drug in the tumor is high enough, the requirement for the neutron beam flux can be reduced; on the contrary, if the concentration of the boron-containing drug in the tumor is low, a high flux of superthermal neutrons is required to give the tumor a sufficient dose.
- the IAEA's requirement for the flux of the superthermal neutron beam is that the number of superthermal neutrons per square centimeter per second is greater than 10 9.
- the neutron beam under this flux can roughly control the treatment of current boron-containing drugs. Within one hour, the short treatment time not only has advantages in patient positioning and comfort, but also can more effectively utilize the limited residence time of boron-containing drugs in the tumor.
- fast neutrons can cause unnecessary normal tissue doses, they are regarded as pollution.
- the dose is positively correlated with neutron energy. Therefore, the content of fast neutrons should be minimized in the design of neutron beams.
- Fast neutron pollution is defined as the dose of fast neutrons per unit of superthermal neutron flux.
- the IAEA's recommendation for fast neutron pollution is less than 2 x 10 -13 Gy-cm 2 /n.
- Gamma rays are strong penetrating radiation, which will non-selectively cause the dose deposition of all tissues along the path of the neutron beam. Therefore, reducing the gamma-ray content is also a necessary requirement for beam design.
- Gamma-ray pollution is defined as the unit superheated neutron flux The accompanying gamma-ray dose, the IAEA's recommendation for gamma-ray pollution is less than 2 x 10 -13 Gy-cm 2 /n.
- thermal neutrons Due to the fast attenuation speed and poor penetration ability of thermal neutrons, most of the energy is deposited in the skin tissues after entering the human body. Except for epidermal tumors such as melanoma, which need to use thermal neutrons as the neutron source for boron neutron capture therapy, the brain Deep tumors such as tumors should reduce the content of thermal neutrons.
- the IAEA recommends that the ratio of thermal neutron to superthermal neutron flux is less than 0.05.
- the ratio of neutron current to flux represents the directionality of the beam. The larger the ratio, the better the forward direction of the beam.
- the high forward neutral beam can reduce the surrounding normal tissue dose caused by neutron divergence. Improve the depth of treatment and flexibility of posture.
- the IAEA recommends that the ratio of neutron current to flux is greater than 0.7.
- the prosthesis is used to obtain the dose distribution in the tissue, and the beam quality factors of the prosthesis are derived according to the dose-depth curve of the normal tissue and the tumor.
- the following three parameters can be used to compare the therapeutic benefits of different neutron beams.
- the tumor dose is equal to the depth of the maximum dose of normal tissue. After this depth, the dose of tumor cells is less than the maximum dose of normal tissue, that is, the advantage of boron neutron capture is lost. This parameter represents the penetration ability of the beam. The larger the effective treatment depth, the deeper the tumor depth that can be treated, and the unit is cm.
- the tumor dose rate of effective treatment depth is also equal to the maximum dose rate of normal tissue. Because the total dose received by normal tissue is a factor that affects the total dose that can be given to the tumor, the parameter affects the length of the treatment time. The larger the effective treatment depth and the dose rate, the shorter the irradiation time required to give a certain dose to the tumor, and the unit is Gy/mA -min.
- the effective treatment dose ratio received by the tumor and normal tissue is called the effective treatment dose ratio; the average dose can be calculated by integrating the dose-depth curve.
- Irradiation time ⁇ 30min (the proton current used by the accelerator is 10mA)
- RBE Relative Biological Effectiveness
- the neutron capture treatment equipment 100 for realizing neutron capture treatment is equipped with a neutron beam generating assembly 1, an irradiation room for irradiating a neutron beam to an irradiated object, such as a patient, 2.
- a neutron beam generating assembly 1 for preparation work, communication room 4 connecting the irradiation room 2 and preparation room 3, management room 5 for implementing irradiation control, positioning device (not shown) for positioning the patient, for placing the patient
- the mounting table 6 that moves in the preparation room 3 and the irradiation room 2 and a control system 7 for controlling and managing the treatment process.
- the neutron beam generating module 1 is configured to generate a neutron beam outside the irradiation chamber 2 and be capable of irradiating the neutron beam to a patient placed in the irradiation chamber 2, and a collimator 20 is provided in the irradiation chamber 2.
- the preparation room 3 is a room for performing the preparation work required before irradiating the neutron beam to the patient.
- the preparation room 3 is equipped with a simulated collimator 30.
- the preparation work includes fixing the patient on the mounting table 6 and treating the patient's tumor. Carry out positioning and make three-dimensional positioning marks, etc.
- the management room 5 is a room used to manage and control the overall treatment process performed by the boron neutron capture therapy device 100.
- the system 7 controls the start and stop of the irradiation of the neutron beam, the position adjustment of the mounting table 6, and the like.
- the mounting table 6 is used to carry the patient to perform rotation, translation, and lifting movements together.
- the control system 7 is only a general term here, it can be a set of general control system, that is, the start and stop of the neutron beam irradiation, the position adjustment of the mounting table 6, etc. are all controlled by a set of systems, or There are multiple control systems, that is, the start and stop of neutron beam irradiation, and the position adjustment of the mounting table 6 are controlled by one control system.
- the stage 6 on which the patient is placed is adjusted to the corresponding position.
- the control system 7 includes an irradiation parameter selection device 71 that selects the best possible irradiation point and irradiation angle, and a conversion unit 72 that converts the parameters of the feasible best irradiation point and irradiation angle into the coordinate parameters of the mounting table 6.
- the adjustment section 73 that adjusts the mounting table 6 to the coordinate position obtained from the conversion section 72, and the start-stop section 74 that controls the start and stop of the irradiation of the neutron beam.
- each set of irradiation parameters includes the irradiation point and irradiation angle of the neutron beam.
- the irradiation parameter selection device 71 includes a sampling unit 711, a calculation unit 712, and a selection unit 713. First, the sampling unit 711 selects multiple groups of irradiation Point and irradiation angle. Next, the calculation unit 712 calculates the evaluation value corresponding to each group of irradiation points and irradiation angles. Then, the optimization unit 713 uses the evaluation value calculated by the calculation unit 712 to select all the sampled irradiation points and irradiation angles. A set of optimal practicable irradiation parameters is selected.
- the optimal selection unit 713 eliminates the irradiation parameters that cannot be implemented in the actual treatment process and selects a set of optimal practicable irradiation parameters.
- the sampling unit 711 selects the irradiation point and the irradiation angle can be random or regular.
- the calculation of the evaluation value is to calculate the organ track of the patient through which the neutron beam passes. That is, the calculation unit 712 calculates that the neutron beam enters The depth of incidence behind the human body and the type of organ that it passes through, and then according to the track information of the neutron beam passing through the human body, it is judged whether the tumor falls within the maximum treatable depth range corresponding to the set of irradiation parameters.
- the information is to calculate the corresponding evaluation value of the group of irradiation points and irradiation angles based on data such as organ boron concentration, organ radiation sensitivity factor and neutron beam characteristic information set by the user; if not, give the irradiation point and irradiation angle a value Special evaluation value, re-sampling and calculation of neutron beam irradiation point and irradiation angle.
- the optimal selection unit 713 needs to eliminate these unavailable irradiation points and irradiation angles.
- the sampling part 711 reads the patient’s CT/MRI/PET-CT and other images with clear human anatomy, one by one Define the contours of various organs, tissues and tumors, and set the type and density of materials. After completing the definition of the contour, material and density, select the irradiation point and irradiation angle of the neutron beam, and the selection of the irradiation point and the irradiation angle. It can be forward selection or reverse selection. The forward selection determines the location of the irradiation point outside the body and can be sampled sequentially at a fixed angle or distance interval.
- neutron beam angle It can be set as the vector direction from the irradiation point to the center of mass of the tumor or the deepest part of the tumor; inverse selection is to determine the irradiation point within the range of the tumor.
- the irradiation point can be the center of mass of the tumor or the deepest part, and the neutron beam angle can be used Random sampling or sampling at a predetermined interval angle; after determining the irradiation point and irradiation angle of the neutron beam, the calculation unit 712 calculates the track of the organ through which the neutron beam passes, that is, calculates that the neutron beam enters The type and thickness of the organ that the human body passes through.
- the track information After obtaining the track information of the neutron beam passing through the human body, it is judged whether the tumor falls within the maximum treatable depth range. If so, the track information is used as the basis to combine with the user Set the organ boron concentration, organ radiation sensitivity factor and neutron beam characteristics, and calculate the evaluation value corresponding to the irradiation point and the irradiation angle; if not, give a special evaluation value and re-irradiate the neutron beam Sampling of points and irradiation angles, after completing the calculation of the evaluation value, record the irradiation point, the irradiation angle and the corresponding evaluation value.
- the report is output; the optimal part 713 selects a set of optimal and implementable irradiation parameters from all the sampled irradiation parameters.
- the calculation unit 712 can output the data of the irradiation point and the irradiation angle and the corresponding evaluation value in the form of 3D or 2D images. In this case, the doctor or physicist can more intuitively judge the pros and cons of the irradiation point and the irradiation angle .
- the optimal selection unit 713 After the optimal selection unit 713 ranks the pros and cons of each group of irradiation points and angles, it verifies whether each group of irradiation points and angles can be implemented in order from the best to the worst, until it finds the best set of implementable.
- the irradiation point and the irradiation angle may also, after calculating the evaluation value, first find out all the impractical irradiation points and irradiation angles, and then eliminate these impractical irradiation points and irradiation angles, and finally, in the remaining irradiation points and irradiation angles.
- the optimal group of angles is selected for neutron capture treatment; the optimal part 713 can also pre-exclude unimplementable irradiation points and irradiation angles before calculating the evaluation value, and then the optimal group can be selected after the calculation is completed
- the irradiation point and the irradiation angle are used for neutron capture treatment.
- the process of selecting the best can be performed automatically by related equipment, or partially interspersed with manual manual work, or it can be performed completely manually, that is, no selection part 713 is provided.
- the irradiation points and irradiation angles that cannot be implemented can be listed by experienced doctors. It can also be determined by the simulation of related equipment. The same applies to the ranking of the evaluation value and the selection of the optimal irradiation point and the irradiation angle after excluding the non-implementable irradiation point and the irradiation angle.
- the conversion unit 72 After obtaining the optimal irradiation point and irradiation angle that can be implemented, the conversion unit 72 combines the patient's CT/MRI/PET-CT information, positioning information, structural information of the stage 6 and so on to convert the parameters of the irradiation point and irradiation angle For the coordinate parameters that the mounting table 6 needs to move into position during the irradiation process, the adjustment unit 73 adjusts the mounting table 6 to a predetermined position based on the coordinate information obtained from the conversion unit 72.
- the positioning device further confirms whether the irradiation point and irradiation angle of the neutron beam relative to the patient's tumor are the same as the preselected optimal irradiation point and irradiation angle, if not, Manually adjust the position of the patient or the position of the mounting table 6 to ensure that the neutron neutron beam irradiates the patient's tumor at the best irradiation point and irradiation angle, or drive the adjustment unit 73 to adjust the position of the mounting table 6 to ensure that the neutron neutron beam is at its best Optimal irradiation point and irradiation angle to irradiate the patient's tumor.
- a first screen door 21 is provided between the irradiation room 2 and the communication room 4, and a second screen door 31 is provided between the communication room 4 and the preparation room 3.
- a shield wall with a maze can be used instead of the first shield door 21 and the second shield door 31.
- the shape of the maze includes, but is not limited to, a "Z" shape, a "bow” shape, and a "self” shape. shape.
- the evaluation value is calculated based on the characteristics of the neutron beam, the organ radiation sensitivity factor and the organ boron concentration. Corresponding to a certain irradiation point and irradiation angle, the weighting factor (W(i)) of organ i is calculated as shown in formula 1. I(i), S(i) and C(i) are the neutron intensity, the radiation sensitivity factor of organ i, and the boron concentration of organ i, respectively.
- I(i) is obtained by integrating the depth intensity or dose curve of the neutron beam used in the simulated human body, as shown in formula 2, where i(x) is the depth of the therapeutic neutron beam in the approximate human body Intensity or dose curve function, x 0 -x is the depth range of organ i in the neutron beam track.
- the evaluation value corresponding to the neutron beam can be obtained, as shown in formula 3, in this calculation, the tumor The weighting factor of should not be included in the calculation.
- the degree of harm to normal tissues during treatment can be judged more intuitively.
- the evaluation ratio factor can also be used for evaluation, which is defined as the ratio of the evaluation value to the tumor weight factor. The expected therapeutic effect of the angle.
- I(i), S(i) and C(i) are transformed from multiplication to phase.
- Add; I(i), S(i) and C(i) are respectively multiplied by the power of n, n depends on the situation, can be an integer multiple of 1 or other multiples;
- i(x) can be x 0- The average or median between x is multiplied by (x 0 -x), or any calculation method that can be consistent with the calculation result of the intensity integral.
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Abstract
Description
Claims (15)
- 一种中子束的照射参数选取装置,所述照射参数包括照射点和照射角度,其特征在于:所述照射参数选取装置包括:取样部,选取多组照射点和照射角度;计算部,计算出每组照射点和照射角度对应的评价值;及择优部,根据计算部计算出的评价值,在所有取样的照射点和照射角度中选取一组最佳的可实施的照射点和照射角度。
- 根据权利要求1所述的照射参数选取装置,其特征在于:所述计算部计算出中子束进入患者后入射的深度和所经过的器官的种类,然后根据中子束通过人体的径迹信息则判断肿瘤是否落于该组照射点和照射角度对应的最大可治疗深度范围内,若是,则以此径迹信息为依据配合用户设定的器官含硼浓度、器官辐射敏感因数及中子束特性信息等数据计算该组照射点和照射角度对应的评价值。
- 根据权利要求1所述的照射参数选取装置,其特征在于:所述择优部在所有取样的照射点和照射角度中剔除在实际照射过程中不可实施的照射点和照射角度并选取一组最优的可实施的照射点和照射角度。
- 如权利要求1-3项中任意一项所述的照射参数选取装置的使用方法,其特征在于:包括以下步骤:取样部读取患者如CT或MRI或PET-CT具有明确人体解剖的影像,逐一定义各个器官、组织及肿瘤的轮廓,并给设定的材料种类及密度,在完成轮廓、材料及密度的定义后,选取中子束的照射点及照射角度;计算部计算中子束所通过的器官的径迹,即计算出中子束进入人体后所经过的器官的种类及其厚度,在取得中子束通过人体的径迹信息后,则判断肿瘤是否落于最大可治疗深度范围内,若是,则以此径迹信息为依据结合用户设定的器官含硼浓度、器官辐射敏感因数及中子束特性等信息,计算该照射点和照射角度对应的评价值;若否,则给予最差的评价值,完成评价值的计算后,对照射点、照射角度及对应的评价值进行纪录;择优部在所有取样的照射参数中选取一组最优的可实施的照射参数。
- 根据权利要求4所述的照射参数选取装置的使用方法,其特征在于:所述照射点与照射角度的选取,可以是顺向选取或逆向选取,顺向选取是将照射点决定于人体外的位置并可按照固定的角度或距离间隔依序取样,也可以透过随机取样的方式进行取样;逆向选取则是将照射点决定于肿瘤范围内,其照射点可以是肿瘤质心或最深处,而照射角度则可以利用随机取样或依预定的间隔角度取样的方式进行;中子束角度则可设定为照射点至肿瘤质心或肿 瘤最深处的向量方向。
- 根据权利要求4所述的照射参数选取装置的使用方法,其特征在于:所述择优部将每一组照射点和照射角度的优劣的进行排序之后,从优到劣依次验证每一组照射点和照射角度是否可实施,直到找出一组可实施的最优的照射点和照射角度。
- 根据权利要求4所述的照射参数选取装置的使用方法,其特征在于:在进行评价值的计算之后,所述择优部先找出所有的不可实施的照射点和照射角度,然后剔除这些不可实施的照射点和照射角度,最后,在留下的照射点和照射角度中选取最优的一组。
- 根据权利要求4所述的照射参数选取装置的使用方法,其特征在于:所述择优部在进行评价值的计算之前,预先排除不可实施的照射点和照射角度,则计算完成之后选取最优的一组。
- 根据权利要求4所述的照射参数选取装置的使用方法,其特征在于:所述计算部将照射点、照射角度及对应的评价值的数据以3D或2D图像的形式输出。
- 根据权利要求4-8项中任意一项所述的照射参数选取装置的使用方法,其特征在于:所述择优部择优过程可以是完全由相关设备自动进行,也可以部分穿插人工手动。
- 一种用于控制中子捕获治疗设备的控制***,所述中子捕获治疗设备包括用于载置患者的载置台,所述控制***包括:如权利要求1-3项中任意一项所述的照射参数选取装置;转换部,将可实施的最佳照射点和照射角度的参数转换为载置台需要移动到位的坐标参数;及调整部,将载置台调整到从转换部得到的坐标位置。
- 根据权利要求11所述的控制***,其特征在于:所述转换部结合患者的CT/MRI/PET-CT信息、摆位信息、载置台的结构信息等将可实施的最佳照射点和照射角度的参数转换为在照射过程中载置台需要移动到位的坐标参数。
- 根据权利要求11或12所述的控制***的使用方法,其特征在于:包括以下步骤:照射参数选取装置选取可实施的最佳照射点和照射角度;转换部将可实施的最佳照射点和照射角度的参数转换为载置台需要移动到位的坐标参数;调整部将载置台调整到从转换部得到的坐标位置。
- 根据权利要求13所述的控制***的使用方法,其特征在于:所述照射参数选取装置的使用方法如下:首先,取样部选取多组照射点和照射角度,接下来,计算部计算出每组照 射点和照射角度对应的评价值,然后,择优部根据计算部计算出的评价值,在所有取样的照射点和照射角度中选取一组最佳的可实施的照射点和照射角度。
- 根据权利要求14所述的控制***的使用方法,其特征在于:所述计算部将每组照射点和照射角度及其对应的评价值的数据以3D或2D图像的形式输出。
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EP20867547.0A EP4035731A4 (en) | 2019-09-25 | 2020-09-24 | IRRADIATION PARAMETER SELECTION APPARATUS AND METHOD OF USE AND CONTROL SYSTEM COMPRISING SUCH APPARATUS AND METHOD OF USE |
JP2022518985A JP7437491B2 (ja) | 2019-09-25 | 2020-09-24 | 照射パラメータ選択装置及びその使用方法、該装置を含む制御システム及びその使用方法 |
AU2020355832A AU2020355832B2 (en) | 2019-09-25 | 2020-09-24 | Irradiation parameter selection apparatus and usage method thereof and control system comprising said apparatus and usage method thereof |
CA3150365A CA3150365C (en) | 2019-09-25 | 2020-09-24 | Irradiation parameter selection apparatus and usage method thereof and control system comprising said apparatus and usage method thereof |
US17/690,134 US20220193452A1 (en) | 2019-09-25 | 2022-03-09 | Irradiation parameter selection apparatus and usage method thereof and control system comprising the apparatus and usage method thereof |
AU2024200068A AU2024200068A1 (en) | 2019-09-25 | 2024-01-04 | Irradiation parameter selection apparatus and usage method thereof and control system comprising said apparatus and usage method thereof |
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CN201910908121.9 | 2019-09-25 | ||
CN201910908121.9A CN112546454A (zh) | 2019-09-25 | 2019-09-25 | 中子捕获治疗设备及照射参数选取装置的使用方法 |
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