WO2020249045A1 - Leave-on oral care compositions - Google Patents
Leave-on oral care compositions Download PDFInfo
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- WO2020249045A1 WO2020249045A1 PCT/CN2020/095595 CN2020095595W WO2020249045A1 WO 2020249045 A1 WO2020249045 A1 WO 2020249045A1 CN 2020095595 W CN2020095595 W CN 2020095595W WO 2020249045 A1 WO2020249045 A1 WO 2020249045A1
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- oral care
- care composition
- toothpaste
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- daltons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Definitions
- the present invention relates to oral care compositions comprising a hyaluronic acid or a salt thereof for promoting Gum Health of a user.
- oral care compositions provide a leave-on formula which provide both good spreadability and retention property, so as to provide improved sensory experience and Gum Health benefit for the user.
- Desirable products require sufficient substantivity and rheological properties to enable application to the oral cavity, to adhere to the oral tissue and to release the contained oral care benefits agents over an extended period of time.
- the viscosity should not be so high that the users can feel globular portions of the newly applied product that has not spread well over the tissue upon application.
- few, if any, products can meet all users’ needs. For example, some products have relatively low viscosity to provide good spreadability but are not sticky/tacky enough so hard to retain on the gum line or into the gum sulcus, while some other products are too sticky/tacky but are hard to spread.
- a novel technology for formulating a leave-on oral care composition is developed by the inventors to meet at least some of the needs described above. Particularly, it is a surprising discovery that a leave-on oral care composition exhibiting a viscosity profile within in a specific range (such as the Viscosity Consistency Coefficient K between about 50 Pa ⁇ s to about 250 Pa ⁇ s as measured at 22°C at a shear rate range of 0.1-10s -1 ) and/or a mucoadhesion property within a specific range (such as a Mucoadhesive Index of no less than about 0.6 FI%, as measured according to the Mucoadhesion Test Method described hereinafter) provides users with a desirable sensory feel. Particularly, such leave-on oral care compositions strike a good balance between different sensory aspects, such as spreadability, retention and/or adhesion.
- a specific range such as the Viscosity Consistency Coefficient K between about 50 Pa ⁇ s to about 250 Pa ⁇ s as measured at 22°C at a
- the leave-on oral care composition has an optimal viscosity so as to provide a good spreadability.
- the leave-on oral care composition is not heavy, overly sticky/tacky and provide users enjoyable experiences, such as refreshing, safe, and effective feel.
- the leave-on oral care composition containing a hyaluronic acid having optimal viscosity as well as optimal adhesion work can provide the users an improved Gum Health benefit, such as better wound healing benefit.
- the leave-on oral care composition of the present invention which exhibits improved wound healing benefit and barrier function benefit, may in turn help to relieve gingival pain, promote gingival regeneration, accelerate repairing of mucosal/gingival damage and healing of gingival bleeding wound, and/or enhancing gingival immunity/resistance.
- the leave-on oral care composition may further help forming a protective film over lesion and irritation caused by ill-fitting dentures.
- the leave-on oral care composition may further help repairing or healing of gingival damage post root scaling/planning or gum grafts.
- the leave-on oral care composition may even further to help improve hydration to the mucosal and even help alleviate or relieve dry mouth.
- the leave-on oral care composition after brushing teeth, or as the last step of oral hygiene regimen. It is advantageous that the leave-on oral care composition is applied on the soft tissue of the oral cavity, leaving for more than 2 minutes, preferably more than 10 minutes, and without being rinsed off or expectorated.
- the delivery carrier may comprise strip, film of material, dental tray, aligner, sponge material, applicator, or mixtures thereof.
- the present invention is directed to an oral care composition
- an oral care composition comprising a hyaluronic acid or a salt thereof, wherein the composition has a Viscosity Consistency Coefficient K of from about 50 Pa ⁇ s to about 250 Pa ⁇ s as measured at 22°C with a shear rate range of 0.1-10 s -1 .
- the oral care composition has a Mucoadhesion Index of no less than 0.6 FI%, as measured according to the Mucoadhesion Test Method described therein.
- the oral care composition is a leave-on composition.
- the hyaluronic acid has a weight average molecular weight from about 900,000 Daltons to about 5,000,000 Daltons, preferably from about 900,000 Daltons to about 2,000,000 Daltons. More preferably, the hyaluronic acid is present in the amount of from about 0.1%to about 5.0%, more preferably from about 0.2%to about 0.8%, by weight of the composition.
- the above-mentioned oral care composition further comprises from about 0.1%to about 10%, preferably from about 0.5%to about 5%, more preferably from about 1%to about 4%, by weight of the composition, of polyacrylic acid.
- the above-mentioned oral care composition further comprises from about 0.1%to about 10%, preferably from about 0.5%to about 5%, more preferably from about 1%to about 4%, by weight of the composition, of an additional polymer selected from natural gum, linear sulfated polysaccharide, anionic cellulose, nonionic cellulose derivative, polyvinyl pyrrolidine, and combinations thereof.
- the above-mentioned oral care composition further comprises from about 30%to about 85%, preferably from more than about 40%to about 80%, preferably from about 45%to about 75%, by weight of the composition, of total water content.
- the above-mentioned oral care composition is substantially free of abrasives, preferably essentially free of abrasives.
- a method of improving Gum Health of a subject using the oral care composition as defined therein comprising the step of applying the oral care composition onto the intraoral tissue of the subject, on which the oral care composition is left without removal for a duration of time from 1 minute to 1000 minutes, preferably from 2 minutes to 200 minutes; optionally the applying step can be conducted as the last step of an oral hygiene regimen.
- a method of improving Gum Health of a subject comprising at least two steps: (a) brushing teeth with a toothpaste, preferably an antibacterial toothpaste, more preferably a stannous containing toothpaste, and even more preferably a toothpaste containing a stannous ion source and an amino acid; and subsequently, preferably immediately followed by (b) applying the oral care composition as defined herein onto the intraoral tissue of a subject, preferably applying along the gingival margin, sulcus or pockets, on which the oral care composition is left for a duration of time from 1 minute to 1000 minutes.
- a toothpaste preferably an antibacterial toothpaste, more preferably a stannous containing toothpaste, and even more preferably a toothpaste containing a stannous ion source and an amino acid
- kits comprising an oral care composition of the present invention and a delivery carrier, wherein the delivery carrier comprises strip, film of material, dental tray, aligner, sponge material, applicator, or mixtures thereof.
- the kit comprises an oral care composition of the present invention and an applicator having a handle and a head.
- a kit comprising a toothpaste and an oral care composition of the present invention.
- the kit comprises an antibacterial toothpaste and the oral care composition of the present invention, where the toothpaste is preferably a stannous-containing toothpaste, more preferably is a toothpaste comprising a stannous ion source and an amino acid.
- the toothpaste and the oral care composition are sequentially applied to improve Gum Health.
- compositions of the present invention can comprise, consist of, and consist essentially of the essential elements and limitations of the invention described herein, as well as any of the additional or optional ingredients, components, steps, or limitations described herein.
- the words "preferred” , "preferably” and variants refer to embodiments of the invention that afford certain benefits, under certain circumstances. However, other embodiments may also be preferred, under the same or other circumstances. Furthermore, the recitation of one or more preferred embodiments does not imply that other embodiments are not useful; and is not intended to exclude other embodiments from the scope of the invention.
- gingival gel or “gum gel” as used herein means a product or a composition is in a form of gel which intent to primarily applied to the gum of a subject, preferably more than 50%of the product or composition is applied to the gum.
- leave-on means a product or a composition is adopted or applied onto a surface for a certain amount of time, e.g. more than one minute, preferably more than two minutes.
- a “leave-on” gel means a gel product or composition which is intent not to be rinsed off or expectorated.
- Gum Care means those benefits aiming to alleviate one or more symptoms of the earlier stage of gum disease (i.e., gingivitis) , which includes: relief of red, swollen, or tender gums; and/or stem gum bleeding.
- Gum Health refers to inherent or promoted benefits of an oral care composition to provide "Gum Care” benefits that include at least improve gingival wound healing, as well as, providing additional improve reduction of bacterial activity to mitigate the harmful effects of bacteria as it relates to gum disease, including gingivitis, periodontitis or both.
- promoting means to promote and/or enhance the Gum Health benefits associated with using the oral care compositions of the present invention in the oral cavity.
- substantially free refers to the presence of no more than 0.05%, preferably no more than 0.01%, and more preferably no more than 0.001%, of an indicated material in a composition, by total weight of such composition.
- essentially free means that the indicated material is not deliberately added to the composition, or preferably not present at analytically detectable levels. It is meant to include compositions whereby the indicated material is present only as an impurity of one of the other materials deliberately added.
- oral hygiene regimen or “regimen” can be for the use of two or more separate and distinct treatment steps for oral health. e.g. toothpaste, mouth rinse, floss, toothpicks, spray, water irrigator, massager.
- total water content means both free water and water that is bound by other ingredients in the oral care composition.
- the oral care composition described in the present invention is configured for applying on the gingival tissue, as well as other soft tissue (e.g. buccal mucosa) inside the oral cavity of a subject. It has been surprisingly discovered that an oral care composition having both an optimal viscosity and a good adhesion and retention efficacy provides a better sensory benefit to the users, and also is particularly useful for promoting Gum Health benefits to users.
- the oral care composition described therein is a leave-on composition.
- the leave-on composition is applied to the gingival tissue, e.g. gumline area, and left on for more than 2 minutes, preferably more than 10 minutes, more preferably more than 30 minutes and more preferably 60 minutes or longer.
- the leave-on composition is applied to the gingival tissue as the last step of oral hygiene regimen.
- the leave-on composition of the present invention is applied after brushing teeth, and optionally after using mouth rinse and/or floss.
- the present invention is directed to an oral care composition which is in a gel form. It is desirable to have a gel for use in the present invention that enables easy application, thin layer formation and evenly spread into gingival sulcus/pockets and along gingival
- the oral care composition has a Viscosity Consistency Coefficient K of about 50 Pa ⁇ s to about 250 Pa ⁇ s, as measured by the Rheological Test method described herein.
- the oral care composition has a Viscosity Consistency Coefficient K of about 50 Pa ⁇ s to about 200 Pa ⁇ s, preferably from about 50 Pa ⁇ s to about 150 Pa ⁇ s, more preferably from about 50 Pa ⁇ s to about 120 Pa ⁇ s, even more preferably from 50 Pa ⁇ s to 100 Pa ⁇ s.
- This optimal viscosity profile range provides better sensory experience of spreadability for a user. If a product is too viscous, it would be hard for a user to spread it evenly onto gingival tissue. If the product has a too low viscosity, it is runny and hard to be retained on appropriate area by finger or applicator.
- the oral care composition of present invention has a desirable mucoadhesion property.
- Mucoadhesion can be defined as adhesive interaction between two surfaces where one is at least mucosa for a given period through interfacial forces with a consequent decreased in the surface energy.
- Mucoadhesion polymers for oral care application should ideally (1) easily retain hydrophilic and lipophilic active ingredients and not hinder their release; (2) promote active ingredient penetration and absorption, (3) adhere as quickly as possible to biological substrate and be retained for a period of time, (4) be safe, (5) be cost effective and (6) provide user acceptable application.
- the oral care composition of present invention has a Mucoadhesion Index in the range of not less than 0.6 FI%, as measured by the Mucoadhesion Test Method described herein.
- the oral care composition has a Mucoadhesion Index of no less than about 0.8 FI%, more preferably no less than about 1.0 FI%.
- the oral care composition may have a Mucoadhesion Index of no less than about 1.2 FI%, or no less than about 1.3 FI%, or no less than about 1.5 FI%, or no less than about 1.8 FI%, or no less than about 2.0 FI%.
- the oral care composition has a Mucoadhesion Index of less than about 20 FI%, preferably less than about 15 FI%, more preferably less than about 10 FI%.
- the oral care composition of the present invention comprises a hyaluronic acid or a salt thereof.
- Hyaluronic acid is a polysaccharide present in the connective tissue of vertebrates, a polymer of glucuronic acid and n-acetyglucosylamine, and is a member of glucosamine family with a high molecular weight.
- Hyaluronic acid (Hyaluronan) is an indispensable component of intact, healthy gingiva, and oral mucosal tissue. It has many properties that make it a potentially ideal molecule for assisting wound healing by inducing early granulation tissue formation, inhibiting inflammation, promoting epithelial turnover and also connective tissue angiogenesis.
- the hyaluronic acid used in the present invention has a weight average molecular weight (M.W. ) of from about 900,000 Daltons to about 5,000,000 Daltons, preferably from about 900,000 Daltons to about 3,000,000 Daltons; more preferably from about 900,000 Daltons to about 2,000,000 Daltons.
- the molecular weight of the hyaluronic acid can be measured using Gel Electrophoresis method.
- the hyaluronic acid of the present invention is present in the amount of from about 0.1%to about 5%by weight of the composition.
- the hyaluronic acid is present in the amount of from about 0.2%to about 2%, more preferably from about 0.2%to about 0.8%, by weight of the composition.
- the hyaluronic acid is present in the amount of about 0.2%, or about 0.3%, or about 0.4%, or about 0.5%, or about 0.6%, or about 0.7%, or about 0.8%, or about 0.9%, or about 1.0%, by weight of the composition.
- Any salt of the hyaluronic acid suitable for oral care product can be used in the present invention.
- the hyaluronate salt may be sodium hyaluronate.
- the oral care composition of the present invention comprises polyacrylic acid as a mucoadhesive polymer.
- Polyacrylic acid (PAA) polymer is a generic term for the synthetic high molecular weight polymers of acrylic acid. These may be homopolymers of acrylic acid, crosslinked with an allyl ether pentaerythritol, allyl ether of sucrose or allyl ether of propylene. And, in a water solution at neutral pH, PAA is an anionic polymer, i.e. many of the side chains of PAA will lose their protons and acquire a negative charge. This makes PAAs polyelectrolytes, with the ability to absorb and retain water and swell to many times their original volume.
- Polyacrylic acid is also called carbomer as tradename.
- polymers such as and are polymers of acrylic acid, crosslinked with polyalkenyl ethers or divinyl glycol.
- Carbomer commercial codes e.g. 940 TM , indicate the molecular weight and the specific components of the polymer.
- the polyacrylic acid used in the invention is present in the amount of from about 0.1%to about 10%by weight of the oral care composition.
- the polyacrylic acid is present in the amount of about 0.2%to about 5%, or about 0.5%to about 8%, or about 1.0%to about 5%, by weight of the oral care composition.
- the oral care composition of the present invention may comprise an additional polymer.
- the oral care composition comprises from about 0.1%to about 10%, preferably from about 0.5%to about 6%, more preferably from about 1%to about 5%, yet still more preferably from about 1.3%to about 2.6%, by weight of the composition, of the additional polymer.
- the additional polymer is selected from natural gum, linear sulfated polysaccharide, anionic cellulose, nonionic cellulose derivative, polyvinyl pyrrolidine, polymers comprising at least a polycarboxylated ethylene backbone, and combinations thereof.
- a natural gum is selected from the group consisting of gum karaya, gum arabic (also known as acacia gum) , gum tragacanth, xanthan gum, and combination thereof. More preferably, the natural gum is xanthan gum.
- Xanthan gum is a polysaccharide secreted by the bacterium Xanthomonas camestris. Generally, xanthan gum is composed of a penta-saccharide repeat units, comprising glucose, mannose, and glucuronic acid in a molar ratio of 2: 2: 1, respectively.
- the chemical formula (of the monomer) is C 35 H 49 O 29 .
- the xanthan gum is from CP Kelco Inc (Okmulgee, US) .
- the linear sulfated polysaccharide is a carrageenan.
- carrageenan include Kappa-carrageenan, Iota-carrageenan, Lambda-carrageenan, and combinations thereof.
- the linear sulfated polysaccharide is Iota-carrageenan.
- the anionic cellulose is a carboxymethyl cellulose ( “CMC” ) .
- the CMC is prepared from cellulose by treatment with alkali and monochloroacetic acid or its sodium salt. Different varieties are commercially characterized by viscosity.
- One commercially available example is Aqualon TM branded CMC from Ashland Special Ingredients (e.g., Aqualon TM 7H3SF; Aqualon TM 9M3SF Aqualon TM TM9A; Aqualon TM TM12A) .
- the nonionic cellulose or derivative thereof has a weight average molecular weight range of about 50,000 Daltons to about 1,300,000 Daltons, and preferably an average degree of polymerization from 300 to 4,800. More preferably, the nonionic cellulose or derivative thereof is hydroxyethyl cellulose ( "HEC" ) . In other examples, the nonionic cellulose may be hydroxypropyl cellulose or hydroxymethyl cellulose.
- HEC hydroxyethyl cellulose
- the polymer comprising at least a polycarboxylated ethylene backbone is selected from the group consisting of: co-polymers of maleic anhydride with methyl vinyl ether having a weight average molecular weight of from about 30,000 Daltons to about 1,000,000 Daltons; and co-polymers of maleic acid and acrylic acid or methacrylic.
- the GANTREZ TM series of polymers are co-polymers of maleic anhydride with methyl vinyl ether having a weight average molecular weight (M.W. ) of about 30,000 Daltons to about 1,000,000 Daltons.
- M.W. weight average molecular weight
- These co-polymers are available for example as GANTREZ TM AN139 (M.W. 500,000 Daltons) , AN119 (M.W. 250,000 Daltons) and S-97 Pharmaceutical Grade (M.W. 70,000 Daltons) , from Ashland Chemicals (Kentucky, USA) .
- the ACUSOL TM and the SOKALAN series of polymers include homopolymers of acrylic acid and copolymers of maleic acid and acrylic acid or methacrylic. Examples are 0: 1000 to 1000: 0 copolymers of maleic acid with acrylic acid having a weight average molecular weight (M.W. ) of about 2,000 to about 1,000,000 Daltons.
- M.W. weight average molecular weight
- copolymers are commercially available as ACUSOL TM 445 and 445N, ACUSOL TM 531, ACUSOL TM 463, ACUSOL TM 448, ACUSOL TM 460, ACUSOL TM 465, ACUSOL TM 497, ACUSOL TM 490 from Dow Chemicals (Michigan, USA) and as CP 5, CP 7, CP 45, and CP 12 S from BASF (New Jersey, USA) .
- the ratio of the mucoadhesive polymer and the additional polymer in the oral care composition of the present invention is from about 5: 1 to about 1: 5, preferably from about 3: 1 to about 1: 3.
- the ratio of the polyacrylic acid and the additional polymer in the present oral care composition, by weight is about 4: 1, or about 3: 1, or about 2: 1, or about 1.5: 1, or about 1: 1, or about 1: 1.5, or about 1: 2, or about 1: 2.5, or about 1: 3, or about 1: 4, or about 1: 5.
- orally acceptable carrier means a liquid or semi-solid vehicle such as a paste or a gel for containing the active ingredients of the present invention and delivering them to the oral cavity.
- Water is commonly used as a carrier material in oral compositions due to its many benefits. For example, water is useful as a processing aid, is benign to the oral cavity and assists in quick foaming of toothpastes.
- Water may be added as an ingredient in its own or it may be present as a carrier in other common raw materials such as, for example, sorbitol and sodium lauryl sulphate.
- total water content as used herein means the total amount of water present in the oral care composition, whether added separately or as a solvent or carrier for other raw materials but excluding that which may be present as water of crystallization in certain inorganic salts.
- the oral care composition of the present invention comprises at least about 30%of a total water content.
- the oral care composition comprises from more than about 35%to about 85%of a total water content.
- the compositions include from about 40%to about 80%, alternatively from about 45%to about 75%, alternatively from about 50%to about 70%, alternatively from about 50%to about 60%, alternatively from about 45%to about 55%, alternatively from about 55%to about 65%, alternatively from about 65%to about 75%, alternatively combinations thereof, of a total water content.
- the oral care composition of the present invention is substantially free of abrasives.
- abrasive for the purpose of present invention, includes calcium-containing abrasives and silica abrasives.
- the calcium-containing abrasives may be selected from the group consisting of calcium carbonate, dicalcium phosphate, tricalcium phosphate, calcium orthophosphate, calcium metaphosphate, calcium polyphosphate, calcium oxyapatite, sodium carbonate, and combinations thereof.
- the calcium carbonate can be selected from the group consisting of fine ground natural chalk, ground calcium carbonate, precipitated calcium carbonate, and combinations thereof.
- the silica abrasives may generally have an average particle size ranging from 0.1 to 30 ⁇ m, and preferably from 5 to 15 ⁇ m.
- the silica abrasives can be precipitated silica or silica gels such as the silica xerogels marketed under the trade name "Syloid" by the W.R. Grace&Company, Davison Chemical Division and precipitated silica materials such as those marketed by the J.M. Huber Corporation under the trade name, particularly the silicas carrying the designation 119, 118, 109 and 129.
- the oral care composition of the present invention contains low levels of abrasives.
- the oral care composition may comprise from 0%to about 5%by weight of the composition, of abrasives, alternatively from 0%to about 3%, alternatively from 0%to about 2%, alternatively from 0%to about 1%, alternatively less than about 3%, or less than about 2%,or less than about 1%, or less than about 0.5%, by weight of the composition.
- the composition is substantially free of the abrasives, more preferably free of the abrasives.
- the oral care compositions herein may contain humectants.
- the humectants serve to keep the oral care composition from hardening upon exposure to air, to give a moist feel to the mouth, and, for particular humectants, to impart a desirable sweetness of flavor.
- Suitable humectants for the present invention include edible polyhydric alcohols such as glycerin, sorbitol, xylitol, erythritol, butylene glycol, polyethylene glycol, propylene glycol, and combinations thereof.
- the humectant is selected from sorbitol, glycerin, and combinations thereof.
- the humectant is glycerin.
- the humectant is sorbitol.
- the oral care composition comprises from about 1%to less than about 50%of humectants by weight of the composition, preferably from about 10%to about 40%.
- the oral care composition contains from about 15%to about 30%of glycerin by weight of the oral care composition.
- the oral care composition of the present invention is substantially free of ethanol, preferably essentially free of ethanol.
- the ethanol is not desirable, in some cases, as it may cause irritating feeling to the users.
- the oral care compositions herein may include from about 0.001%to about 5%, alternatively from about 0.01%to about 4%, alternatively from about 0.1%to about 3%, alternatively from about 0.5%to about 2%, alternatively combination thereof, of a flavorant composition by weight of the oral care composition.
- flavorant composition is used in the broadest sense to include flavor ingredients, or sensates, or sensate agents, or combinations thereof.
- Flavor ingredients may include those described in U.S. Publication No. 2012/0082630A1 at paragraph 39; and sensates and sensate ingredients may include those described at paragraphs 40–45, incorporated herein by reference.
- flavor compositions or flavor ingredients include: mint oils, wintergreen, clove bud oil, cassia, sage, parsley oil, marjoram, lemon, orange, propenyl guaethol, heliotropine, 4-cis-heptenal, diacetyl, methyl-p-tert-butyl phenyl acetate, methyl salicylate, ethyl salicylate, 1-menthyl acetate, oxanone, a-irisone, methyl cinnamate, ethyl cinnamate, butyl cinnamate, ethyl butyrate, ethyl acetate, methyl anthranilate, iso-amyl acetate, iso-amyl butyrate, allyl caproate, eugenol, eucalyptol, thymol, cinnamic alcohol, octanol, octanal, decan
- Sensates such as cooling, warming, and tingling agents are useful to deliver signals to the users.
- the most well-known cooling agent is menthol, particularly 1-menthol, which is found naturally in peppermint oil.
- synthetic cooling agents many are derivatives of or are structurally related to menthol, i.e., containing the cyclohexane moiety, and derivatized with functional groups including carboxamide, ketal, ester, ether and alcohol. Examples include the p-menthanecarboxamide compounds such as N-ethyl-p-menthan-3-carboxamide (known commercially as "WS-3" ) .
- An example of a synthetic carboxamide cooling agent that is structurally unrelated to menthol is N, 2, 3-trimethyl-2-isopropylbutanamide.
- Additional exemplary synthetic cooling agents include alcohol derivatives such as 3-1-menthoxy-propane-1, 2-diol, isopulegol, p-menthane-3, 8-diol; menthone glycerine acetal (known commercially as "MGA" ) ; menthyl esters such as menthyl acetate, menthyl acetoacetate, menthyl lactate, and monomenthyl succinate.
- alpha-keto enamine derivatives described in U.S. Pat. No. 6,592,884, including 3-methyl-2- (1-pyrrolidinyl) -2-cyclopenten-1-one (3-MPC) , 5-methyl-2- (1-pyrrolidinyl) -2-cyclopenten-1-one (5-MPC) ; 2, 5-dimethyl-4- (1-pyrrolidinyl) -3 (2H) -furanone (DMPF) ; icilin (also known as AG-3-5, chemical name 142-hydroxyphenyl] -4- [2-nitrophenyl] -1, 2, 3, 6-tetrahydropyrimidine-2-one) .
- warming agents include ethanol; nicotinate esters, such as benzyl nicotinate; polyhydric alcohols; nonanoyl vanillyl amide; nonanoic acid vanillyl ether; vanillyl alcohol alkyl ether derivatives such as vanillyl ethyl ether, vanillyl butyl ether, vanillyl pentyl ether, and vanillyl hexyl ether; isovanillyl alcohol alkyl ethers; ethylvanillyl alcohol alkyl ethers; veratryl alcohol derivatives; substituted benzyl alcohol derivatives; substituted benzyl alcohol alkyl ethers; vanillin propylene glycol acetal; ethylvanillin propylene glycol acetal; ginger extract; ginger oil; gingerol; zingerone; or combinations thereof.
- nicotinate esters such as benzyl nicotinate
- polyhydric alcohols nonano
- tingling agents examples include capsaicin; homocapsaicin, jambu oleoresin, zanthoxylum peperitum, saanshool-I, saanshool II, sanshoamide, piperine, piperidine, spilanthol, 4- (1-methoxymethyl) -2-phenyl-1, 3-dioxolane, or combinations thereof.
- the oral care compositions herein can further include herbal ingredients such as extracts of chamomile, oak bark, melissa, rosemary and salvia. These, and some of the herb-derived flavoring components can be included at levels just sufficient to provide a contribution to the flavor or they can be added at higher levels, such as 1%or more, in order to provide a greater therapeutic effect.
- the oral care composition of the present invention may comprise preservatives.
- the preservatives may be benzyl alcohol, phenoxyethanol, sorbitan caprylate (Velsan ) , 1-2 hexanediol&caprylyl glycol (Symdiol ) , parabens and or combinations.
- the paraben may comprise methyl paraben or propyl paraben or combination thereof.
- Levels of benzyl alcohol or phenoxyethanol may be present at the amount of from greater than about 0.10%to about 0.40%, preferably about 0.12%to about 0.30%, more preferably about 0.15%to about 0.23%, alternatively from about 0.18%to about 0.22%, alternatively from about 0.19%to about 0.21%, alternatively about 0.20%, by weight of the composition.
- the levels of Velsan maybe present at the amount of from about 0.10%to about 0.50%, preferably from about 0.20%to about 0.40%, more preferably alternatively from about 0.25%to about 0.30%.
- the level of Symdiol maybe present from about 0.10%to about 0.80%, preferably from about 0.10%to about 0.50%and more preferably about 0.20%to about 0.30%.
- Levels of paraben may be present at the amount of about 0.01%to about 0.11%, preferably about 0.02%to about 0.10%, more preferably about 0.03%to about 0.09%, by weight of the composition.
- the composition comprises from about 0.005%to about 0.1%, preferably from about 0.01%to about 0.08%, alternatively from about 0.01%to about 0.05%, of propyl paraben by weight of the composition.
- the composition comprises from about 0.01%to about 0.1%, preferably from about 0.02%to about 0.07%, alternatively from about 0.03%to about 0.05%, of methyl paraben by weight of the composition.
- the paraben comprises a combination of methyl paraben and propyl paraben, wherein there is a greater weight ratio of methyl paraben to propyl paraben.
- the paraben is methyl paraben and propyl paraben, wherein the weight ratio of methyl paraben to propyl paraben is from about 5: 3 to about 30: 3, preferably greater than about 5: 3 to about 20: 3, more preferably from about 6: 3 to about 15: 3.
- the oral care compositions of the present invention are substantially free of triclosan (i.e., 5-chloro-2- (2, 4-dichlorophenoxy) phenol) , preferably free of triclosan.
- triclosan i.e., 5-chloro-2- (2, 4-dichlorophenoxy) phenol
- the oral care compositions herein may include a sweetening agent.
- sweeteners such as saccharin, dextrose, sucrose, lactose, xylitol, maltose, levulose, aspartame, sodium cyclamate, D-tryptophan, dihydrochalcones, acesulfame, sucralose, neotame, and mixtures thereof.
- Sweetening agents are generally used in oral care compositions at levels of from about 0.005%to about 5%, alternatively about 0.01%to about 1%, by weight of the composition, alternatively from about 0.1%to about 0.5%, alternatively combinations thereof.
- the oral care compositions herein may include a coloring agent (i.e., pigments, dyes and opacifiers) .
- the coloring agent may be in the form of an aqueous solution, preferably 1%coloring agent in a solution of water.
- Titanium dioxide may also be added to the present oral care composition. Titanium dioxide is a white powder which adds opacity to the oral care compositions. Titanium dioxide generally comprises from about 0.25%to about 5%, by weight of the composition. It will be appreciated that selected components for the compositions must be chemically and physically compatible with one another.
- the oral care compositions may include an effective amount of an anti-calculus agent, which in one embodiment may be present from about 0.05%to about 50%, alternatively from about 0.75%to about 25%, alternatively from about 0.1%to about 15%.
- an anti-calculus agent which in one embodiment may be present from about 0.05%to about 50%, alternatively from about 0.75%to about 25%, alternatively from about 0.1%to about 15%.
- Non-limiting examples include those described in U.S. Publication No. 2011/0104081A1 at paragraph 64, and those described in U.S. Publication No. 2012/0014883A1 at paragraphs 63 to 68, as well as the references cited therein.
- One example is a pyrophosphate salt as a source of pyrophosphate ion.
- the composition comprises tetrasodium pyrophosphate (TSPP) or disodium pyrophosphate or combinations thereof, preferably from about 0.01%to about 2%, more preferably from about 0.1%to about 1%of the pyrophosphate salt by weight of the composition.
- TSPP may provide not only calcium chelating thereby mitigating plaque formation, but also may also provide the additional benefit of monofluorophosphate stabilization (in those formulations containing monofluorophosphate) .
- the present oral care composition may comprise other oral care active.
- the oral care composition may comprise vitamins selected from Vitamin C, Vitamin E, Vitamin B5, and the combinations thereof.
- Vitamin means said vitamin and all derivatives thereof.
- the ingredients may provide additional benefits to the oral care composition.
- extracellular antioxidants e.g. ascorbate or ⁇ -tocopherol, as chain breaking or radical scavenging antioxidants, helps control and modulate the intracellular reactive oxygen species (ROS) that can cause host-tissue damage.
- ROS reactive oxygen species
- the use of dexpanthenol can improve epithelialization and induce the proliferation phase in the wound healing of damaged tissue.
- the oral care composition may comprise from about 0.1%to about 10%, preferably from about 0.5%to about 8%, or from about 0.5%to about 5%, by weight of the composition, of vitamins selected from Vitamin C, Vitamin E, Vitamin B5, or the combinations thereof.
- vitamins described in the present invention means said vitamins and all derivatives thereof.
- the present oral care composition may further comprise the usual and conventional ancillary components such as surfactants, anti-microbial agents, fluoride ions, and other ingredients that are known to one skilled in the art. It will be appreciated that selected components for the oral care compositions must be chemically and physically compatible with one another.
- the present invention also relates to methods for treating the oral cavity comprising applying to the intraoral tissue (e.g. oral mucosa, gingiva) of the oral cavity of a subject, particularly the gum tissue, leaving on for more than 2 minute, preferably more than 10 minutes, more preferably more than 30 minutes, or more than 60 minutes or longer.
- the method of use herein comprises contacting a subject’s oral mucosa (e.g. gingival margin or gingival sulcus/pockets) with the oral care composition according to the present invention.
- the present invention further relates to a method of improving Gum Health of a subject using the oral care composition described herein comprising the step of applying the oral care composition onto the intraoral tissue of a subject, preferably applying along the gingival margin or sulcus at least once a day, preferably at least twice a day, more preferably every time immediately after brushing teeth.
- the term “immediately” herein means within 1 hour, preferably within 30 minutes, more preferably within 15 minutes, alternatively within 10 minutes.
- the oral care composition can be applied onto the intraoral tissue of a subject by using an applicator, which applicator has a handle and a head, to spread the oral care composition along the gingival margin or sulcus of the subject.
- the oral care composition is applied on the head of the applicator before being applied onto the intraoral tissue.
- the present invention further relates to a method of improving Gum Health of a subject, comprising at least two steps: (a) brushing teeth with an antibacterial toothpaste, preferably a stannous containing toothpaste, and immediately followed by (b) applying the oral are composition as defined herein onto the intraoral tissue of a subject, preferably applying along the gingival margin, sulcus or pockets.
- a Rheological Test Method is described for assessing viscosity profile (and ran according to manufacturing instructions) .
- the viscosity profiles are tested on a TA AR2000 rheometer (available from TA Instruments, New Castle, United States) by using Dentifrice Macro Rheology Test procedure.
- the geometry used is 40 mm steel parallel plate with solvent trap. Dentifrice is placed on the Peltier Plate of AR2000 rheometer and the Gap setting is 1000 micron.
- Dentifrice Macro Rheology Test consists of stress sweep oscillation, frequency sweep oscillation and steady state flow tests.
- Shear flow test is a viscosity testing mode to measure the viscosity at different shear rates.
- Steady state flow test is a flow in which the velocity at every point does not vary with time.
- the three main parameters in this test are viscosity, shear rate and shear stress.
- Power Law Model is a well-known model used to characterize the relationship between viscosity or shear stress and shear rate over the range of shear rates where shear thinning occurs in a Non-Newtonian fluid. It quantifies overall viscosity range and degree of deviation from Newtonian behavior.
- K is known as the Viscosity Consistency Coefficient, describing the overall range of viscosities across the part of the flow curve that is being modelled.
- the exponent “n” is known as the rate index.
- K and ⁇ can be determined by Power Law Model fitting. Based upon rate index n, the Power Law Model describes three basic types of flow:
- Viscosity Consistency Coefficient K Pa ⁇ s
- Mucoadhesion Test Method is provided. Test samples are labeled with Fluorescein isothiocyanate (FITC) at room temperature for 1 hour. The resulting solutions are dialyzed in phosphate buffered saline (PBS) for 48h in order to remove the free FITC molecules. The silica wafers are treated with a mixture of ethanol/ (3-Aminopropyl) triethoxysilane (APTES) /ammonia solution (20: 4: 1, v/v/v) for 8 hours and are then rinsed with ethanol and water, and dried to obtain the amine-functionalized silica wafers (NH 2 -SW) .
- FITC Fluorescein isothiocyanate
- PBS phosphate buffered saline
- APTES 3-Aminopropyl triethoxysilane
- NH 2 -SW amine-functionalized silica wafers
- NH 2 -SW are incubated in mucin solution for 8 hours at room temperature.
- the mucin modified silica wafers are incubated with test sample in a PBS buffer in a shaker at 37°C for 12 hours followed by rinsing with deionized water.
- the fluorescence images of the mucin modified silica wafers are taken by a fluorescence microscopy, and used for measurement of Fluorescent Intensity (FI) in ImageJ software (National Institutes of Health, USA, (https: //imagej. nih. gov/ij/) ) .
- FI Fluorescent Intensity
- the Fluorescent Intensity Percentage ( “FI%” ) , which is used to describe the “Mucoadhesion Index” , is the fluorescent pixels relative to total pixels in a normalized image field. Therefore, a first test sample having a higher FI%has stronger mucoadhesion compared to a second test sample having a lower FI%.
- Sample preparation pipe out of gel or ointment sample from package as the amount of '0.03 ⁇ 0.005g' to the test plate.
- the probe is compressed into each sample, follow the determined programmed sequence (speed of 10mm/sec, force of 5g for stage 2; speed of 1mm/sec, Force of 200g for stage 4, and time is 1 sec for stage 5) .
- Adhesiveness the work necessary to overcome the attractive forces between the surface of the sample and the surface of the probe.
- the adhesiveness values (unit: gf*sec) describes the energy necessary to overcome the attractive forces between the surface of the sample and the surface of the probe.
- Example A Examples 1 to 5
- Examples 1 to 5 are gel compositions according to the present invention, which are shown in Table 1 below with amounts of components in wt%. They may be suitably prepared by conventional methods chosen by the formulator.
- Table 2 shows the viscosity and the mucoadhesion values of the Inventive Example 1 and the benchmark products. It can be seen from the results that the inventive Example 1 exhibits a desirable viscosity.
- the Comparative Example 6 (Sunstar Gel)
- the Comparative Example 7 (Gengigel Gel)
- the Comparative Example 9 (Lion Gel) all exhibit relatively low viscosity profile which indicate undesirable retention or adhesion property. A gel with too low viscosity may flow too fast to adhere to or be retained on the user’s gum.
- the comparative Example 8 shows an extremely high viscosity profile, which indicates that such product has poor spreadability, i.e. too thick to be spread evenly on oral tissue surface.
- Example D Assay for Measuring Improve Gingival Health in the Oral Cavity
- the following assay is used to determine improved gingival wound healing in the oral cavity for the oral care compositions of the present invention and controls.
- the assay involves gentle probing of gingival crevice to assess presence or absence of bleeding. Gingivitis is assessed according to the Mazza modification of the Papillary Bleeding Index ( "PBI” , and according to Muhlemann, H.R.: J. Prev. Dent. 1977; 4: 6) , otherwise referred to as the "Mazza Index” to determine the number of bleeding sites (as defined by Mazza, 1981) . For this measurement, probing is done on the mesiofacial and the distolingual surface of each tooth, at a maximum of 56 sites.
- PBI Papillary Bleeding Index
- the probe is placed in the gingival sulcus to a depth of approximately 0.5 mm to 1.0 mm and swept along the soft tissue aspect of the sulcus from its insertion point to the tip of the interdental papilla. All facial or lingual surfaces of each quadrant are swept before measurements are made. The measurements are made beginning with the first tooth swept.
- Oral soft tissue and gingivitis examination using the Mazza Index are conducted at specified time points and assessed according to Mazza Index as defined as in Table 4.
- subjects who met the study entrance requirement are randomly assigned to treatment or control groups balanced on Baseline Mazza Index scores using a SAS randomization program.
- Individuals meeting the following criteria are included: be at least 18 years of age; possess a minimum of 18 natural anterior teeth; have at least 10 bleeding sites as measured by Mazza Index at initial visit (i.e., Baseline) ; have gingivitis but not periodontitis; be in good general health as determined by the Investigator/designee based on a review of the medical history/update for participation in the study.
- Clinical parameters for each subject are monitored across the whole study. Individuals that fell into the exclusion criteria are excluded from study participation.
- Subjects assigned to the experimental group, additionally post brushing, distributed 0.25 gram of inventive oral are composition on gum massage applicator and applied topically to upper teeth/gingival, both lingual and facial surface for 1 minute. The procedure is repeated, whereby 0.25 gram of the Inventive oral care composition Ex 1., distributed to the gum massager and applied topically to the lower teeth/gingival, both lingual and facial surface and refrained from food, drink and smoking for 1 hour.
- Mazza Index assessments are performed on the subjects to score for reduction of bleeding sites at Baseline, Day 3 and at Day 20 (i.e., end of the study) .
- the data are analyzed with analysis of covariance ( "ANCOVA” ) , with the respective Baseline as the model covariate using the Statistical Analysis System ( “SAS” ) .
- the results in terms of the number of bleeding sites, based on the Mazza Index, of the control groups and treatment group are averaged (as well as their confidence intervals) and defined in Table 6.
Abstract
Description
Claims (14)
- An oral care composition, comprising a hyaluronic acid or a salt thereof, wherein the composition has a Viscosity Consistency Coefficient K of from 50 Pa·s to 250 Pa·s as measured at 22℃ at a shear rate range of 0.1-10s -1, and wherein the oral care composition has a Mucoadhesion Index of no less than 0.6 Fluorescent Intensity Percentage ( “FI%” ) , wherein the oral care composition is a leave-on composition.
- The oral care composition according to claim 1, wherein the composition has a Viscosity Consistency Coefficient K of from 50 Pa·s to 200 Pa·s, preferably from 50 Pa·s to 150 Pa·s, more preferably from 50 Pa·s to 100 Pa·s.
- The oral care composition according to claim 1 or 2, wherein the composition has a Mucoadhesion Index of no less than 0.8 FI%, preferably no less than 1.0 FI%, more preferably no less than 1.5 FI%.
- The oral care composition according to any one of the preceding claims, wherein the hyaluronic acid has a weight average molecular weight of from 900,000 Daltons to 5,000,000 Daltons, preferably from 900,000 Daltons to 2,000,000 Daltons; preferably the hyaluronic acid is present in the amount of from 0.1%to 5.0%, more preferably from 0.2%to 0.8%, by weight of the composition.
- The oral care composition according to any of preceding claims, further comprising from 0.1%to 10%, preferably from 0.5%to 5%, more preferably from 1%to 4%, by weight of the composition, of a polyacrylic acid.
- The oral care composition according to any one of the preceding claims, further comprising an additional polymer, wherein the additional polymer selected from natural gum, linear sulfated polysaccharide, anionic cellulose, nonionic cellulose derivative, co-polymers of maleic anhydride with methyl vinyl ether, polyvinyl pyrrolidine, and combinations thereof; preferably the additional polymer is selected from xanthan gum, carrageenan, carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxymethyl cellulose, polyvinyl pyrrolidine, co-polymers of maleic anhydride with methyl vinyl ether having a weight average molecular weight of 30,000 Daltons to 1,000,000 Daltons, and combinations thereof; wherein the additional polymer is present in the amount of from 0.1%to 10%, preferably from 0.5%to 5%, more preferably from 1%to 4%, by weight of the composition.
- The oral care composition according to any one of the preceding claims, having a total water content of from 30%to 85%, preferably from 45%to 80%, more preferably from 50%to 75%, by weight of the composition.
- The oral care composition according to any one of the preceding claims, wherein the oral care composition is substantially free of abrasives, preferably essentially free of abrasives, more preferably free of abrasives.
- The oral care composition according to any one of the preceding claims, further comprising a vitamin, preferably the vitamin is selected from the group consisting of Vitamin C, Vitamin E, Vitamin B5, and combinations thereof.
- A method of improving Gum Health of a subject using the oral care composition as defined in any one of the preceding claims, comprising the step of applying the oral care composition onto the intraoral tissue of the subject, on which the oral care composition is left without removal for a duration of time from 1 minute to 1000 minutes, preferably from 2 minutes to 200 minutes; optionally the applying step can be conducted as the last step of an oral hygiene regimen.
- A method of improving Gum Health of a subject, comprising at least two steps:(a) brushing teeth of the subject with an antibacterial toothpaste, preferably a stannous-containing toothpaste, more preferably a toothpaste containing a stannous ion source and an amino acid; and(b) subsequently, applying, preferably immediately applying, the oral care composition as defined in any one of claims 1 to 9 onto the intraoral tissue of the subject, preferably applying along the gingival margin, sulcus or pockets, on which the oral care composition is left without removal for a duration of time from 1 minute to 1000 minutes, preferably from 2 minutes to 200 minutes.
- The method of claim 10 or claim 11, wherein the applying the oral care composition onto the intraoral tissue of the subject is conducted by using an applicator having a handle and a head to spread the oral care composition onto the intraoral tissue of the subject.
- A kit comprising a toothpaste and an oral care composition defined by any one of claims 1 to 9, wherein preferably the toothpaste is an antibacterial toothpaste, more preferably the toothpaste is a stannous-containing toothpaste, and most preferably the toothpaste is a toothpaste comprising a stannous ion source and an amino acid.
- A kit comprising an oral care composition defined by any one of claims 1 to 9, and a delivery carrier, wherein the delivery carrier comprises strip, film of material, dental tray, aligner, sponge material, applicator, or mixtures thereof.
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BR112021024274A BR112021024274A2 (en) | 2019-06-14 | 2020-06-11 | Compositions for rinse-free oral care |
CN202080043674.3A CN114040742A (en) | 2019-06-14 | 2020-06-11 | Leave-on oral care compositions |
CA3140252A CA3140252A1 (en) | 2019-06-14 | 2020-06-11 | Leave-on oral care compositions |
AU2020292655A AU2020292655B2 (en) | 2019-06-14 | 2020-06-11 | Leave-on oral care compositions |
MX2021015126A MX2021015126A (en) | 2019-06-14 | 2020-06-11 | Leave-on oral care compositions. |
EP20823109.2A EP3982912A1 (en) | 2019-06-14 | 2020-06-11 | Leave-on oral care compositions |
US16/899,834 US11904041B2 (en) | 2019-06-14 | 2020-06-12 | Leave-on oral care compositions |
US18/390,158 US20240122838A1 (en) | 2019-06-14 | 2023-12-20 | Leave-on oral care compositions |
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WO2021170065A1 (en) * | 2020-02-26 | 2021-09-02 | The Procter & Gamble Company | Oral care compositions for gum health |
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