WO2020231429A1 - New use of a milk frother apparatus and a method for the preparation of a therapeutic foam for the treatment of varicose veins and other medical conditions. - Google Patents

New use of a milk frother apparatus and a method for the preparation of a therapeutic foam for the treatment of varicose veins and other medical conditions. Download PDF

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Publication number
WO2020231429A1
WO2020231429A1 PCT/US2019/032504 US2019032504W WO2020231429A1 WO 2020231429 A1 WO2020231429 A1 WO 2020231429A1 US 2019032504 W US2019032504 W US 2019032504W WO 2020231429 A1 WO2020231429 A1 WO 2020231429A1
Authority
WO
WIPO (PCT)
Prior art keywords
foam
preparation
treatment
methods
varicose veins
Prior art date
Application number
PCT/US2019/032504
Other languages
French (fr)
Inventor
Jose Vicente COLL-MAZZEI
Veronica S. COLL
Victoria S COLL
Original Assignee
Coll Mazzei Jose Vicente
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Coll Mazzei Jose Vicente filed Critical Coll Mazzei Jose Vicente
Publication of WO2020231429A1 publication Critical patent/WO2020231429A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/08—Ethers or acetals acyclic, e.g. paraformaldehyde
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/20—Mixing gases with liquids
    • B01F23/23—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids
    • B01F23/235—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids for making foam
    • B01F23/2351—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids for making foam using driven stirrers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/05—Stirrers
    • B01F27/11—Stirrers characterised by the configuration of the stirrers
    • B01F27/118—Stirrers in the form of brushes, sieves, grids, chains or springs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
    • B01F27/88—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with a separate receptacle-stirrer unit that is adapted to be coupled to a drive mechanism
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/50—Movable or transportable mixing devices or plants
    • B01F33/501—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use
    • B01F33/5014—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use movable by human force, e.g. kitchen or table devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Definitions

  • An apparatus and a method are described for the preparation of a therapeutic foam for the treatment of varicose vein and other medical conditions.
  • a foam can be made by passing the gas/liquid mixture between two syringes through a three way stop cock valve (Tessari method) or a two-way valve (Easy Foam ®). These methods with the two syringes can be strenuous, tiring and wearing, and the foam that is accomplished is not homogeneous.
  • the therapeutic foam for the treatment of the varicose veins comprises a sclerosing agent solution combined with physiological gases.
  • the mixed frothed foam is aspirated or withdrawn with a syringe or any other device and injected in the varicose veins or any other organ or universal process that requires the use of a foam, and in this case, for the treatment of varicose veins.
  • a new use for a milk frothing machine and a new method for the preparation of a therapeutic foam for the treatment of Varicose veins and other medical conditions is presented. It is an improvement to the traditional methods of preparing a sclerosing foam and microfoam for the sclerosis of the varicose veins.
  • An apparatus, machine, device, process and method are disclosed. They will solve the problem of the exhausting, wearing and tiring existing methods and processes of manually creating, mixing and frothing of a foam (Tessari®, Easy Foam®), because it is automatic.
  • the container, ampoule or reservoir are set or placed or positioned on a base that has the power to move and agitate the frothers, rings, springs or ecouvillons.
  • the device has inlets and outlets for the introduction of the solution and the gases
  • the outlets are for the withdrawal of the foam. It can have more than one inlet and more than one outlet.
  • a ring or frother or a spring or an ecouvillon is at the base of the apparatus.
  • Many other sources of energy can be used also
  • the foam can be pressurized or not.
  • the introduced gas can be under pressure and can be monitored by a gauge.
  • the preparation of the foam is done by mixing the sclerosing agents or any substance with the addition of any pressurized gas or not. Then, by means of a motor or any source of propulsion, the gas / liquid mixture is frothed or agitated by the ring or ecouvillon or any agitator. The agitator or frother in the estimated time will create the foam.
  • the present container can be pressurized or not. Furtherly the foam can be stored in another container for use or used directly from the apparatus with a syringe and inject it to the patient in a tissue when required.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Vascular Medicine (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The creation and production of the foam are for universal and extensive use of a foam. In any industry, not only for varicose veins and human use. It is used also for the treatment of vascular malformations, of congenital and hereditary etiology. It will be used also for the treatment of tumors that are vascularized and other tumors. It can be used in any tissue when used therapeutically. It can have many other uses as for the treatment of cysts. It can be used as a contrast media in Ultrasound echograms.

Description

DESCRIPTION. INTERNATIONAL PATENT APPLICATION.
Title of the Invention
New use of a Milk Frother Apparatus and a method for the preparation of a therapeutic foam for the treatment of Varicose veins and other medical conditions.
BACKGROUND
Field of the Invention
An apparatus and a method are described for the preparation of a therapeutic foam for the treatment of varicose vein and other medical conditions.
Description of the Related Art
Many methods and techniques have been described along history to treat varicose veins and its related pathology. Traditionally surgery is performed to treat larger varicose veins and more recently, endovenous laser ablation and radiofrequency also is used. For many years, the use of liquid sclerosis for the treatment of small varicose veins has been used. Alternatively, to surgery, endovenous mechanical ablations and liquid sclerosis, a foam can be made by passing the gas/liquid mixture between two syringes through a three way stop cock valve (Tessari method) or a two-way valve (Easy Foam ®). These methods with the two syringes can be strenuous, tiring and wearing, and the foam that is accomplished is not homogeneous.
The therapeutic foam for the treatment of the varicose veins comprises a sclerosing agent solution combined with physiological gases. The mixed frothed foam is aspirated or withdrawn with a syringe or any other device and injected in the varicose veins or any other organ or universal process that requires the use of a foam, and in this case, for the treatment of varicose veins.
PRIOR ART
In the prior art, the patent was granted to the method and use of a microfoam for sclerosis of varicose veins, with the microfoam, but not to an automatic brother machine for the preparation of the foam for use in vein sclerotherapy. No such an apparatus has been described before. Many milk frothers have been granted with Patents (Karkos, US6095677A), but not an apparatus and a container and a reservoir to specifically create a foam for the sclerosis of veins and any tissue.
SUMMARY
A new use for a milk frothing machine and a new method for the preparation of a therapeutic foam for the treatment of Varicose veins and other medical conditions is presented. It is an improvement to the traditional methods of preparing a sclerosing foam and microfoam for the sclerosis of the varicose veins. An apparatus, machine, device, process and method are disclosed. They will solve the problem of the exhausting, wearing and tiring existing methods and processes of manually creating, mixing and frothing of a foam (Tessari®, Easy Foam®), because it is automatic. This new use of a milk frother in a non-obvious shut, locked, sterile, safe container will be used by sclerotherapists in a medical setting, abandoning, but not necessarily, the manual methods and will be cheaper than the pressurized canister (Varithena ®) for dispensing foam.
DESCRIPTION
The container, ampoule or reservoir are set or placed or positioned on a base that has the power to move and agitate the frothers, rings, springs or ecouvillons.
The device has inlets and outlets for the introduction of the solution and the gases The outlets are for the withdrawal of the foam. It can have more than one inlet and more than one outlet. A ring or frother or a spring or an ecouvillon is at the base of the apparatus. There is an electromagnetic motor or any motor to propel and move the frother to froth and agitate the mixture and the solution for the preparation of the foam. Many other sources of energy can be used also The foam can be pressurized or not. The introduced gas can be under pressure and can be monitored by a gauge.
The preparation of the foam is done by mixing the sclerosing agents or any substance with the addition of any pressurized gas or not. Then, by means of a motor or any source of propulsion, the gas / liquid mixture is frothed or agitated by the ring or ecouvillon or any agitator. The agitator or frother in the estimated time will create the foam. The present container can be pressurized or not. Furtherly the foam can be stored in another container for use or used directly from the apparatus with a syringe and inject it to the patient in a tissue when required.

Claims

CLAIMS. INTERNATIONAL PATENT APPLICATION.
Title of the Invention
New use of a Milk Frother Apparatus and a method for the preparation of a therapeutic foam for the treatment of Varicose veins and other medical conditions.
Authors: Jose V Coll-Mazzei M.D., Victoria S. Coll and Veronica S. Coll
Address: 2643 Miller Ct, Weston, FL 33332
1- It is environmentally safe, small, practical and quiet.
2- It is hundreds of times less expensive than other methods of preparation of the foam in a pressurized cannister (Varithena R®).
3- It is going to improve the results and reduce the complications and side effects of the two syringes and two and three-way stop cock valve methods of production of foam and any other manual methods.
4- The foam will be more homogeneous. The foam is going to have more stability. It will have microbubbles, obtained from more soluble gases when these are selected for use.
5- The process is going to be cleaner, safer, and aseptic techniques will benefit the patients. It can be very easily manufactured and becomes an improvement to the manual methods and processes of preparation of foam. 6- The machine or device or apparatus may take various forms and shapes and sizes and commonly the user withdraws the frothed new formed foam from the device and injects it into a varicose vein. Also, the user can inject directly with a longer hose and connector.
7- The machine is to be also portable and can be disposable.
8- It will resolve the problem of the existing wearing, exhausting, and tiring methods and processes of manually creating and mixing for the preparation of a foam, because it is automatic, and you just need to press a button.
PCT/US2019/032504 2019-05-10 2019-05-15 New use of a milk frother apparatus and a method for the preparation of a therapeutic foam for the treatment of varicose veins and other medical conditions. WO2020231429A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962819527P 2019-05-10 2019-05-10
US62/819,527 2019-05-10

Publications (1)

Publication Number Publication Date
WO2020231429A1 true WO2020231429A1 (en) 2020-11-19

Family

ID=73289204

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2019/032504 WO2020231429A1 (en) 2019-05-10 2019-05-15 New use of a milk frother apparatus and a method for the preparation of a therapeutic foam for the treatment of varicose veins and other medical conditions.

Country Status (1)

Country Link
WO (1) WO2020231429A1 (en)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6345776B1 (en) * 1999-12-23 2002-02-12 Fomo Products Inc. Two-component dispensing gun
US20020042587A1 (en) * 1996-12-17 2002-04-11 Thomas O. Murdock Polymeric foam reservoirs for an electrotransport delivery device
US20060062736A1 (en) * 2003-11-17 2006-03-23 Wright David D I Therapeutic foam
WO2006103353A1 (en) * 2005-03-31 2006-10-05 Alain Monfreux Device for producing a foam formed by gas bubbles and a surfactant liquid
US8167280B2 (en) * 2009-03-23 2012-05-01 Cabochon Aesthetics, Inc. Bubble generator having disposable bubble cartridges
US8875618B2 (en) * 2008-09-01 2014-11-04 Nestec S.A. Appliance for fine steam-frothing a milk-based liquid
WO2017027760A1 (en) * 2015-08-12 2017-02-16 North Carolina State University Platelet membrane-coated drug delivery system

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020042587A1 (en) * 1996-12-17 2002-04-11 Thomas O. Murdock Polymeric foam reservoirs for an electrotransport delivery device
US6345776B1 (en) * 1999-12-23 2002-02-12 Fomo Products Inc. Two-component dispensing gun
US20060062736A1 (en) * 2003-11-17 2006-03-23 Wright David D I Therapeutic foam
WO2006103353A1 (en) * 2005-03-31 2006-10-05 Alain Monfreux Device for producing a foam formed by gas bubbles and a surfactant liquid
US8875618B2 (en) * 2008-09-01 2014-11-04 Nestec S.A. Appliance for fine steam-frothing a milk-based liquid
US8167280B2 (en) * 2009-03-23 2012-05-01 Cabochon Aesthetics, Inc. Bubble generator having disposable bubble cartridges
WO2017027760A1 (en) * 2015-08-12 2017-02-16 North Carolina State University Platelet membrane-coated drug delivery system

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