WO2020213921A1 - Dispositif d'injection de médicament permettant une injection intraveineuse à une concentration uniforme - Google Patents

Dispositif d'injection de médicament permettant une injection intraveineuse à une concentration uniforme Download PDF

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Publication number
WO2020213921A1
WO2020213921A1 PCT/KR2020/005030 KR2020005030W WO2020213921A1 WO 2020213921 A1 WO2020213921 A1 WO 2020213921A1 KR 2020005030 W KR2020005030 W KR 2020005030W WO 2020213921 A1 WO2020213921 A1 WO 2020213921A1
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WO
WIPO (PCT)
Prior art keywords
drug
uniform concentration
fixing
lower plate
injection tube
Prior art date
Application number
PCT/KR2020/005030
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English (en)
Korean (ko)
Inventor
박주영
한문
허형규
이은희
박찬육
Original Assignee
재단법인 대구경북첨단의료산업진흥재단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 재단법인 대구경북첨단의료산업진흥재단 filed Critical 재단법인 대구경북첨단의료산업진흥재단
Priority to KR1020207011256A priority Critical patent/KR102368692B1/ko
Publication of WO2020213921A1 publication Critical patent/WO2020213921A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/1407—Infusion of two or more substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/162—Needle sets, i.e. connections by puncture between reservoir and tube ; Connections between reservoir and tube
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16804—Flow controllers
    • A61M5/16827—Flow controllers controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
    • A61M2005/1587—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body suitable for being connected to an infusion line after insertion into a patient

Definitions

  • the present invention relates to a drug injection device capable of injecting blood vessels at a uniform concentration, and more specifically, drugs having different densities or concentrations can be mixed and injected into blood vessels at a uniform concentration, thereby improving the therapeutic effect of the drug. It relates to a drug injection device.
  • a device for injecting an injection solution into a human body or an animal at a constant rate is mainly used in hospitals, and a Ringer pack or a drug bottle is hung on a high place and a tube is connected to inject it into a blood vessel through a puncture needle.
  • the injection solution was provided in a liquid state, but recently, it is also provided by mixing with any one or more of a mixture of two or more drugs, an emulsion, a slurry, a microbubble, and a liposome.
  • Korean Patent Registration No. 10-1640481 is made to stir the infusion solution by vibrating the container containing the infusion solution and the stirring means provided in the container, so that the target substance contained in the infusion solution is sufficiently stirred. It induces to be injected with a uniform concentration in the state in which the target substance is inoculated to prevent fatal medical accidents that may be caused by non-uniform concentration of the target substance.
  • the container, filter and/or through the infusion liquid level control tube by connecting the expansion tubes to each other, the level of the infusion solution filled in them and the infusion rate of the infusion solution can be more freely controlled, and the infusion solution fills the inside of the filter above the preset water level so that the filter undergoes a sedimentation filtration process.
  • a technique was proposed to induce the injection to be performed so that target substances such as stem cells can be stably filtered without damage to the injection liquid filtration agent, and injected.
  • This technique is described in a configuration that induces the injection solution to be stirred by shaking the stirring means provided in the container, so that the target substance contained in the injection solution can be injected with a uniform concentration in a sufficiently stirred state. Only by stirring through vibration, the target substances can be separated from each other due to the difference in density when substantially injected into the human body.
  • the present invention provides a uniforming unit in which a predetermined length of an injection tube for injecting a chemical solution is wound in a spiral shape, so that chemical solutions having different densities or concentrations including microbubbles, liposomes, etc.
  • An object of the present invention is to provide a drug injection device capable of injecting blood vessels at a uniform concentration that can be injected into the human body and thus improve the therapeutic effect of drugs.
  • the present invention can be connected to each of the chemical liquid supply and the puncture needle at both ends, the injection tube having a uniform portion wound in a predetermined length in a spiral; Including a fixing jig for fixing so that the wound shape of the uniforming unit can be maintained in parallel, wherein a chemical solution containing fluids having different concentrations or densities supplied through the chemical solution supply device passes through the uniforming unit to a uniform concentration. It provides a device for maintaining a uniform concentration of a drug for vascular injection, characterized in that it is injected into the human body through a puncture needle.
  • the chemical solution is characterized in that it contains microbubbles or liposomes.
  • the fixing jig is a lower plate which is formed by winding the injection tube, a flattening part having a predetermined width in a spiral shape, and seated in the center of the upper surface, and having a plurality of first guide holes having a radial length along the circumference thereof;
  • An upper plate corresponding to the lower plate and covering the equalization part, and having a second guide hole corresponding to the first guide hole penetrating therethrough; It characterized in that it comprises a plurality of fixing pieces for preventing separation of the leveling portion provided between the lower plate and the upper plate by sequentially fastening through the first guide hole and the second guide hole.
  • the fixing jig includes: a lower plate having a helical shape by winding the injection tube, a flattening unit having a predetermined width, seated at the center of the upper surface, and having a plurality of first guide holes having a radial length along the circumference thereof; A plurality of fixing pieces each penetrating through the first guide hole; It is configured to include a fixing bracket having a through hole that penetrates into the fixing piece, characterized in that the fixing bracket is pressed and supported by the fixing bracket to support the uniformity seated on the lower plate through the tightening of the fixing piece.
  • a hook is further formed at the central entrance of the upper plate to prevent loosening of the wound equalization part by gripping a part of the injection tube, or a circular step portion further protrudes in the upper center of the lower plate.
  • the injection tube may be wound along the edge of the stepped portion to form a uniform portion.
  • FIGS. 1 to 3 are diagrams of each embodiment including the configuration of a drug injection device capable of injecting blood vessels at a uniform concentration according to the present invention.
  • Figure 5 is a cross-sectional view showing the operating state of the drug injection device capable of injecting blood vessels at a uniform concentration according to the invention.
  • FIG. 6 is a block diagram showing another embodiment of a drug injection device capable of injecting blood vessels at a uniform concentration according to the present invention.
  • FIG. 7 and 8 are experimental photographs showing the effect of the use of a drug injection device capable of injecting blood vessels at a uniform concentration according to the present invention.
  • a drug supply device 100 and a puncture needle 200 may be connected to each of basically both ends, and a predetermined It may be configured to include an injection tube 300 having an equalization portion 310 wound in a spiral length, and a fixing jig 400 that fixes the winding shape of the equalization portion 310 to be maintained on a horizontal plane. have.
  • a solid drug such as an emulsion or a slurry or a therapeutic agent loaded with a fluid drug in a gas such as a micro-bubble and other drugs are mixed and injected into the human body at the same time, or liposomes It is a small spherical material that is in the form of a pocket, and is injected into the human body at the same time by mixing a liquid drug with a carrier material loaded with antibiotics or anticancer drugs, drugs, artificial receptors, etc.
  • drugs having different concentrations or densities are supplied to the injection tube 300 at a constant rate at a constant rate, and the human body through the puncture needle 200 along the injection tube 300 It is injected into the blood vessel of
  • two chemical liquid supply units 100 for supplying drugs having different densities or concentrations are arranged to supply microbubbles or liposomes, etc. on which the drug is mounted to one chemical liquid supply device 100, and the other chemical liquid In the feeder 100, a drug may be supplied and connected to the injection tube 300 to be mixed and supplied as a drug solution L.
  • drugs such as microbubbles or liposomes can be mounted on the drug solution supply device 100.
  • a gas or a fluid may be provided, and these may be mixed through the chemical liquid supply pack 110 to be mixed and supplied as a chemical liquid L.
  • a separate drug solution supply pack 110 containing liquid drugs having different concentrations or densities is provided, so that one is fat-soluble and the other is supplied with a water-soluble drug, or even a liquid component is not mixed with each other. Can supply.
  • a mixed fluid in which drugs (fluids) having different densities or concentrations are mixed (hereinafter, chemical solution (L)) can be injected in a state separated by a difference in density, and the injection tube 300 is in a vertical state.
  • chemical solution (L) a mixed fluid in which drugs (fluids) having different densities or concentrations are mixed
  • the mixed concentration may be injected in a non-uniform state during human injection.
  • the drug solution (L) may contain drugs, microbubbles, liposomes, etc. having different concentrations or densities, and the drug solution (L) mixed with a drug substance mounted on the drug, microbubble or liposome is The degree of mixing may be gradually and uniformly distributed while sufficiently moving in the horizontal direction on a horizontal plane along the injection tube 300.
  • the injection tube 300 may be variously deformed as a tube made of a flexible material such as plastic, vinyl, and rubber.
  • a fixing jig 400 for fixing the equalizing part 310 may be further included in order to maintain the leveling part 310 on a horizontal plane.
  • a chemical solution (L) containing fluids having different densities or concentrations supplied through the chemical solution supply unit 100 It is distributed in a uniform concentration while passing through the homogenizing part 310 and can be injected into the human body through the puncture needle 200.
  • the fixing jig 400 for maintaining the state in which the equalization unit 310 is spirally wound on a horizontal plane may be configured differently through the following embodiments.
  • the fixing jig 400 firstly winds the injection tube 300 so that a flattening unit 310 having a predetermined width in a spiral shape may be seated in the center of the upper surface, and in a radial direction along the periphery.
  • a plurality of first guide holes 411 having a length constitute a lower plate 410 formed therethrough.
  • the lower plate 410 is a panel having a predetermined area in a square or circular shape, and a first guide hole 411 penetrating through a long hole along the outer direction from the center is formed, and the first guide hole 411 is a circumferential It is preferable that the radiation is formed at two or more points along the line.
  • an upper plate 420 formed in the same manner as the lower plate 410 is provided on the lower plate 410, and a second guide hole 421 corresponding to the first guide hole 411 is provided.
  • the leveling portion 310 of the injection tube 300 is fixed in a sandwich manner between the lower plate 410 and the upper plate 420 to maintain a horizontal state.
  • a plurality of fixing pieces 430 are sequentially fastened through the first guide hole 411 and the second guide hole 421, respectively, and are transferred along the first guide hole 411 and the second guide hole 421. / It is possible to prevent separation of the leveling unit 310 provided between the lower plate 410 and the upper plate 420 by moving backward and in close contact with the leveling unit 310.
  • a hook 423 is further formed at the central entrance of the upper plate 420 to hold a part of the injection tube 300 to prevent loosening of the wound equalization part 310.
  • a circular stepped portion 413 is further protruded in the upper center of the lower plate 410 so that the injection tube 300 is wound along the rim of the stepped portion 413 to form a uniforming portion 310. I can.
  • the injection tube 300 is spirally wound along the edge of the stepped portion 413 formed in the center of the lower plate 410, and the hook 423 is connected to the inlet side connected to the chemical liquid supply unit 100.
  • Hang on the upper plate 420 through the entrance and connect to the chemical solution supply unit 100, and the outlet side of the injection tube 300 located outside the spiral wound can be used by connecting to the puncture needle 200 .
  • the fixing jig 400 winds the injection tube 300 so that a flattening unit 310 having a predetermined width in a spiral shape is seated in the center of the upper surface, and the length in the radial direction along the circumference thereof is reduced.
  • the plurality of first guide holes 411 are formed through the lower plate 410 formed therethrough.
  • the lower plate 410 is a panel having a predetermined area in a square or circular shape, as in Example 4, and a first guide hole 411 penetrating through a long hole along the outer direction from the center is formed, and the first guide It is preferable that the ball 411 is radially formed in two or more places along the perimeter.
  • it includes a fixing bracket 440 having a through hole 441 penetrating through the fixing piece 430.
  • the fixing piece 430 is moved forward/reversely along the first guide hole 411 and closely adhered to the outer circumference of the equalizing portion 310 seated on the lower plate 410 and then fastened and fixed.
  • the fixing bracket 440 is in close contact with the upper surface of the equalizing part 310, it may be configured as one body through fastening and fixing.
  • the fixing bracket 440 pressurizes the flattening part 310 seated on the lower plate 410 through the fastening of the fixing piece 430 to prevent separation.
  • a circular stepped portion 413 is further protruded in the upper center of the lower plate 410 so that the injection tube 300 is wound along the rim of the stepped portion 413 to form a uniforming portion 310. I can.
  • a bent part performing the same role as the hook 423 of the upper plate 420 may be further formed at the end of the fixing bracket 440.
  • the fixing bracket 440 is rotated outward so as to have a space inside, winding along the rim of the stepped part 413 to form the uniforming part 310. Thereafter, the fixing bracket 440 is rotated to the upper portion of the equalizing portion 310 and the equalizing portion 310 is fixed to the lower plate 410 through fastening of the fixing piece 430.
  • the equalization unit 310 which is a part of the injection tube 300 having a predetermined length, is spirally wound on the upper portion of the lower plate 410 and is parallel to the ground.
  • the chemical solution L containing fluids having different concentrations or densities gradually has a uniform distribution while passing through the homogenizing unit 310, and thus the puncture needle 200 of the equalizing unit 310 On the) side, the concentration of the mixed chemical solution L is uniformly distributed and supplied to the puncture needle 200.
  • FIG. 7 is a check of the stability of the degree to which the Blood Brain Barrier is opened when a chemical solution containing microbubbles is injected using the drug injection device according to the present invention.
  • the drug injection of the present invention When ultrasonic energy is irradiated by injecting microbubbles into the body with a chemical solution without a device provided, MRI is used to confirm the opening of the cerebrovascular barrier and observe the tissue cells around the cerebrovascular (Histology). It can be seen that red blood cells are observed in the part, which is because the concentration distribution in the blood vessels of the microbubbles is not uniform. It can be seen that, accordingly, it can be seen that the possibility of damage to the brain tissue increases. 7 is the right side of FIG.
  • the opening of the cerebrovascular barrier is confirmed by MRI and tissue cells around the cerebrovascular vessels are recovered.
  • tissue cells around the cerebrovascular As a result of observation, as a result of confirming the opening of the cerebrovascular barrier by MRI, it can be seen that the cerebrovascular barrier is more stably opened.
  • tissue cells around the cerebrovascular Histology
  • red blood cells as shown on the left were not observed. It was confirmed experimentally that there was no damage to the brain tissue. That is, when a chemical solution containing microbubbles is injected at a uniform concentration using the drug injection device, the effect of drug delivery can be increased and the risk can be reduced by stably opening the cerebrovascular barrier without damage to the brain tissue.
  • the peak according to time changes in the peak generation portion (dotted square portion) between the fundamental frequency (Fundamental freq) and the second resonant frequency (Second harmonic freq). It can be seen that a stable cavitation signal is detected as it remains the same, which shows that the microbubbles are distributed at a uniform concentration in the blood vessels and the cerebrovascular barrier is stably opened. Accordingly, it is possible to reduce the risk of brain tissue damage and achieve a higher drug delivery effect by improving the stability of the cerebral vascular barrier opening according to ultrasound irradiation.
  • a chemical liquid supply and a puncture needle may be connected to both ends, respectively, and an injection tube having a uniformization part wound in a spiral shape of a predetermined length; Including a fixing jig for fixing so that the wound shape of the uniforming unit can be maintained in parallel, wherein a chemical solution containing fluids having different concentrations or densities supplied through the chemical solution supply device passes through the uniforming unit to a uniform concentration. It provides a drug injection device that is injected into the human body through a puncture needle, wherein the chemical solution includes microbubbles or liposomes, and the fixing bracket pressurizes and supports the homogenizing part seated on the lower plate through tightening of the fixing piece.
  • a predetermined length of the injection tube for injecting a chemical solution is wound in a spiral shape to provide a uniformity part, so that chemical solutions that cannot be mixed due to different densities in various fluid states such as microbubbles and liposomes can be injected into the human body at a uniform concentration.
  • a drug injection device capable of injecting blood vessels at a uniform concentration that can improve the therapeutic effect of the drug.

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

La présente invention concerne un dispositif d'injection de médicament permettant une injection intraveineuse à une concentration uniforme, et fournissant un dispositif d'injection de médicament comprenant : un tube d'injection dont les deux parties d'extrémité peuvent être reliées à un dispositif d'alimentation en médicament liquide et à une aiguille à paracentèse, respectivement, et qui possède une partie d'uniformisation dans laquelle une longueur prédéterminée du tube d'injection est enroulée en spirale ; et un gabarit de fixation qui fixe la forme enroulée de la partie d'uniformisation de façon à ce qu'elle soit maintenue parallèle, des médicaments liquides qui sont acheminés par le dispositif d'alimentation en médicament liquide et qui comprennent des fluides de différentes concentrations ou densités traversant la partie d'uniformisation et étant injectés à une concentration uniforme dans le corps humain par l'intermédiaire de l'aiguille à paracentèse. Les médicaments liquides comprennent des microbulles ou des liposomes, et la partie d'uniformisation reposant sur une plaque inférieure peut être pressée et supportée par un support de fixation au moyen du serrage d'une pièce de fixation, permettant ainsi d'empêcher sa séparation. Grâce à cette configuration, la partie d'uniformisation est assurée par l'enroulement, en spirale, de la longueur prédéterminée du tube d'injection servant à injecter les médicaments liquides. En conséquence, des médicaments liquides, qui se trouvent dans divers états fluides, tels que des microbulles, des liposomes, et analogues, qui ont des densités différentes et ne se mélangent donc pas, peuvent être injectés à une concentration uniforme dans le corps humain, et ainsi l'effet curatif des médicaments peut être amélioré.
PCT/KR2020/005030 2019-04-15 2020-04-14 Dispositif d'injection de médicament permettant une injection intraveineuse à une concentration uniforme WO2020213921A1 (fr)

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Application Number Priority Date Filing Date Title
KR1020207011256A KR102368692B1 (ko) 2019-04-15 2020-04-14 균일한 농도로 혈관주입이 가능한 약물 주입 장치

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Application Number Priority Date Filing Date Title
KR20190043496 2019-04-15
KR10-2019-0043496 2019-04-15

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011104481A (ja) * 2009-11-13 2011-06-02 Asahi Organic Chemicals Industry Co Ltd 流体混合器
JP2011104483A (ja) * 2009-11-13 2011-06-02 Asahi Organic Chemicals Industry Co Ltd 静的流体混合器及び静的流体混合器を用いた装置
JP2011104482A (ja) * 2009-11-13 2011-06-02 Asahi Organic Chemicals Industry Co Ltd 静止型流体混合器及び静止型流体混合器を用いた装置
KR101640481B1 (ko) * 2016-05-25 2016-07-18 김준우 의료용 주입장치
KR101799812B1 (ko) * 2016-05-31 2017-11-22 원광대학교산학협력단 믹서가 결합된 3d 프린터 및 이를 이용하여 제작된 세포지지체

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011104481A (ja) * 2009-11-13 2011-06-02 Asahi Organic Chemicals Industry Co Ltd 流体混合器
JP2011104483A (ja) * 2009-11-13 2011-06-02 Asahi Organic Chemicals Industry Co Ltd 静的流体混合器及び静的流体混合器を用いた装置
JP2011104482A (ja) * 2009-11-13 2011-06-02 Asahi Organic Chemicals Industry Co Ltd 静止型流体混合器及び静止型流体混合器を用いた装置
KR101640481B1 (ko) * 2016-05-25 2016-07-18 김준우 의료용 주입장치
KR101799812B1 (ko) * 2016-05-31 2017-11-22 원광대학교산학협력단 믹서가 결합된 3d 프린터 및 이를 이용하여 제작된 세포지지체

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KR102368692B1 (ko) 2022-03-02

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