WO2020171690A1 - Système de lecture électroencéphalographique multiple à commande de profondeur linéaire - Google Patents

Système de lecture électroencéphalographique multiple à commande de profondeur linéaire Download PDF

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Publication number
WO2020171690A1
WO2020171690A1 PCT/MX2019/000069 MX2019000069W WO2020171690A1 WO 2020171690 A1 WO2020171690 A1 WO 2020171690A1 MX 2019000069 W MX2019000069 W MX 2019000069W WO 2020171690 A1 WO2020171690 A1 WO 2020171690A1
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WO
WIPO (PCT)
Prior art keywords
motor
electroencephalographic
base
rack
depth control
Prior art date
Application number
PCT/MX2019/000069
Other languages
English (en)
Spanish (es)
Inventor
Nicole Stephanie MUÑOZ FILIPPETTI
Jesús Raúl BELTRÁN RAMÍREZ
Jovan Ricardo ZEPEDA GÓMEZ
Javier ESPINOZA JR.
Olga Berenice MORA SÁNCHEZ
Víctor Manuel LARIOS ROSILLO
José Antonio ORIZAGA TREJO
Ma. Del Rocío MACIEL ARELLANO
Original Assignee
Consorcio De Investigación E Innovación Abierta S.A.P.I. De C.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Consorcio De Investigación E Innovación Abierta S.A.P.I. De C.V. filed Critical Consorcio De Investigación E Innovación Abierta S.A.P.I. De C.V.
Publication of WO2020171690A1 publication Critical patent/WO2020171690A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
    • A61B5/291—Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]

Definitions

  • the present invention is related to the technical field of electronics, communication modules, brain bioelectric activity, medicine, the conversion of neurophysiological measurements into graphic data and continuous monitoring, since it provides a multiple electroencephalographic reading system with control linear depth.
  • Electroencephalography is a neurophysiological examination that is based on the recording of brain bioelectric activity in basal conditions of rest, wakefulness or sleep, and during various activations (usually hyperpnea and intermittent light stimulation) using an electroencephalography device.
  • the outer surface is the cortex and sensory information is received in it; this layer has 9 of the 12 billion neurons that man has.
  • Brain tissue has the ability to generate electrical potentials that are the basis of the organism's excitability.
  • the electroencephalogram is currently an essential method in the affected diagnosis of critical brain phenomena, as well as its evolutionary control and prognosis. And it is one of the most useful tests to support the diagnosis of epilepsy.
  • the parameters of all living beings are monitored in real time at the same time, thus providing many advanced capabilities that include, among others, the comparison of the performance of one living being with that of another; study the performance of a living being at different times of the day; compare the physiology of one living being with another; compare the physiology of a living being with a group of individuals; and compare the physiology of a group of living things with another group of living things.
  • the aforementioned document refers to being a monitoring equipment for physiological and non-physiological parameters, but there is no evidence of performing electroencephalographic recordings at different points of the cerebral cortex and at different depths, nor does it mention the possibility of placing electrodes of automatic way. Another characteristic that is not described is that the operation and obtaining results is remote.
  • Patent document number US8958868 (B2) was also found, with publication date of April 29, 2010, entitled “IMPLANTABLE MULTICHANNEL SYSTEMS AND METHODS FOR NEURONAL WIRELESS RECORDING" where a system to transmit bioelectric signals is described.
  • the system includes an implantable bioelectric sensor for receiving at least one bioelectric signal; an analog-to-time converter for converting the bioelectric signal received from an analog domain into a time-domain signal; and a radio frequency (RF) modulator to transmit the time domain signal.
  • RF radio frequency
  • Figure 1 shows a perspective view of the multiple electroencephalographic reading system with linear depth control.
  • Figure 2 shows an exploded view of the multiple electroencephalographic reading system with linear depth control.
  • Figure 3 shows a top perspective view of the base of the multiple electroencephalographic reading system with linear depth control.
  • Figure 4 shows a top perspective view of the arm of the multiple electroencephalographic reading system with linear depth control.
  • Figure 5 shows a bottom perspective view of the arm of the multiple electroencephalographic reading system with linear depth control.
  • Figure 6 shows a top perspective view of the extension of the multiple electroencephalographic reading system with linear depth control.
  • Figure 7 shows a side perspective view of the motor and gear assembly of the multiple EEG reading system with linear depth control.
  • Figure 8 shows a top perspective view of the rack of the multiple electroencephalographic reading system with linear depth control.
  • Figure 9 shows a top perspective view of the arm assembly, the extension, the motor, the gear and the rack of the reading system Multiple EEG with linear depth control.
  • the multiple electroencephalographic reading system with linear depth control is made up of a base (1), which is flat in a prismatic shape, preferably octagonal and hollow in the center, which allows access to the brain of the animal.
  • a base (1) which is flat in a prismatic shape, preferably octagonal and hollow in the center, which allows access to the brain of the animal.
  • At least two holes (2) are arranged in the base (1), configured to hold said base (1) in the skull of a species to be evaluated, one of the variants of the present invention is that the holes (2) are They can be placed in a hearth arranged on the internal or external circumference of the base (1), as illustrated in figure 3.
  • At least one pivot (3) which is preferably cylindrical, is installed on each of the edges of the base (1).
  • the multiple electroencephalographic reading system with linear depth control has a concave housing (11) for each pivot
  • said casing is configured to assemble with the pivot (3), and has an arm (4) configured to install at the end an extension (5) with fastening means (not illustrated), this configuration allows circular motion in the horizontal plane of the arm
  • a motor (6) which can be stepper or variable speed, is installed at the opposite end of the extension clamp (5), and is configured to transmit the rotation to a gear (7), which preferably is helical and is arranged in the upper part of the motor (6).
  • a rack (8) which is preferably made of a rectangular tubular profile, has grooves (9) that are arranged longitudinally in its rear part to hold onto guides (not illustrated) that are installed in the front part of the engine ( 6), this configuration allows movement in the vertical plane depending on the direction of rotation of the gear (7) to move the rack (8) up or down.
  • At least one electrode holder (10) is arranged in the lower part of the front face of the rack (8), configured to install an electrode (not illustrated) by means of which The brain electrical activity monitoring of the species to be evaluated will be carried out.
  • a microcontroller (not illustrated) is placed on the back of the species to be evaluated, and is connected to the motor (6) to program its operation, indicating the insertion depth of each electrode (not illustrated);
  • a bluetooth module (not illustrated) is installed inside the microcontroller (not illustrated), and is configured to receive programming through an intelligent device and / or a desktop computer, where, once the electrode information has been collected (not illustrated), said information is sent through the bluetooth module (not illustrated) to the smart devices.
  • One of the main advantages of the multiple electroencephalographic reading system with linear depth control, reason for the present invention is that it has the ability to perform the insertion of several electrodes at the same time, at different distances from the cerebral cortex automatically, controlled remotely using a smart device.
  • the fastening means can be screws, bolts, studs and / or the combination of the above.
  • Electrodes can be insulated needle, coaxial needle, bipolar coaxial, fine wire electrodes, and / or the combination of the foregoing.
  • the housing (11) is removable, for in case of that suffers an electrode suffers damage even when the multiple electroencephalographic reading system with linear depth control is installed in the species to be analyzed, it is removed so that at the moment the housing (11) is replaced with the arm (4), the extension ( 5), the motor (6), the rack (8) with the electrode holder (10), this without the need to remove the electroencephalographic reading system of the present invention from the species to be analyzed.
  • Example 1 Process of monitoring and recording brain electrical activity of a mouse.
  • the base (1) is positioned in the mouse to be evaluated by means of surgery, holding the base by means of clamping that pass through the holes (2) and are fixed in the skull, subsequently, the microcontroller (not shown) is held on the back of the mouse for freedom of movement.
  • the arms (4) of the housing (11) and the extensions (5) are positioned aligned to the part of the brain of the mouse where the electrodes (not illustrated) that are installed in the electrode holder are to be inserted. (10) for the monitoring of brain electrical activity, then programming is performed by means of An intelligent device to determine to what depth the rack (8) that is driven by the motor (6) will descend, depending on the distance in which the electrode (not illustrated) enters the cerebral cortex of the mouse.
  • the electrodes record the electrical brain activity of the mouse and send the information to the smart device through the bluetooth module (not illustrated), later, the electrodes are removed through the microcontroller (not illustrated) which activates the drive of the motor (6) to raise the rack (8) to its original position.

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Selective Calling Equipment (AREA)

Abstract

La présente invention concerne un système de lecture électroencéphalographique multiple à commande de profondeur linéaire permettant de réaliser l'insertion de plusieurs électrodes à la fois, à des distances différentes du cortex cérébral de manière automatique, commandé à distance au moyen d'un dispositif intelligent, de sorte que, au moyen de la programmation du moteur, il envoie l'information par bluethotth, déterminant la distance à laquelle un moteur fera tourner un engrenage pour transformer la rotation en un mouvement vertical d'une crémaillère sur laquelle est connectée l'électrode; on élimine l'erreur humaine ce qui évite de provoquer des dommages ou même la mort de l'espèce à évaluer. Un autre des avantages du système de lecture électroencéphalographique multiple à commande de profondeur linéaire pour des espèces petites est que, une fois que l'information de l'étude est recueillie, elle est transmise, par le même module bluetooth, au dispositif intelligent qui obtient l'information en temps réel.
PCT/MX2019/000069 2019-02-21 2019-06-06 Système de lecture électroencéphalographique multiple à commande de profondeur linéaire WO2020171690A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
MX2019002080A MX2019002080A (es) 2019-02-21 2019-02-21 Sistema de lectura electroencefalográfica múltiple con control de profundidad lineal.
MXMX/A/2019/002080 2019-02-21

Publications (1)

Publication Number Publication Date
WO2020171690A1 true WO2020171690A1 (fr) 2020-08-27

Family

ID=72144967

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/MX2019/000069 WO2020171690A1 (fr) 2019-02-21 2019-06-06 Système de lecture électroencéphalographique multiple à commande de profondeur linéaire

Country Status (2)

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MX (1) MX2019002080A (fr)
WO (1) WO2020171690A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3735753A (en) * 1971-11-09 1973-05-29 Humetrics Corp Head harness for eeg electrodes
US20120136233A1 (en) * 2010-11-25 2012-05-31 Sony Corporation Biosignal detecting electrode and biosignal detecting device equipped therewith
US20140051044A1 (en) * 2012-08-17 2014-02-20 Yakob Badower Systems and methods to gather and analyze electroencephalographic data
CN107049307A (zh) * 2017-05-02 2017-08-18 臧大维 全自动脑电信号读取头盔
US20180271374A1 (en) * 2017-03-27 2018-09-27 David Byron Douglas Characterizing neurological function and disease

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3735753A (en) * 1971-11-09 1973-05-29 Humetrics Corp Head harness for eeg electrodes
US20120136233A1 (en) * 2010-11-25 2012-05-31 Sony Corporation Biosignal detecting electrode and biosignal detecting device equipped therewith
US20140051044A1 (en) * 2012-08-17 2014-02-20 Yakob Badower Systems and methods to gather and analyze electroencephalographic data
US20180271374A1 (en) * 2017-03-27 2018-09-27 David Byron Douglas Characterizing neurological function and disease
CN107049307A (zh) * 2017-05-02 2017-08-18 臧大维 全自动脑电信号读取头盔

Also Published As

Publication number Publication date
MX2019002080A (es) 2020-08-24

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