WO2020154935A1 - Device for locating tumour after surgery - Google Patents

Device for locating tumour after surgery Download PDF

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Publication number
WO2020154935A1
WO2020154935A1 PCT/CN2019/073803 CN2019073803W WO2020154935A1 WO 2020154935 A1 WO2020154935 A1 WO 2020154935A1 CN 2019073803 W CN2019073803 W CN 2019073803W WO 2020154935 A1 WO2020154935 A1 WO 2020154935A1
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WO
WIPO (PCT)
Prior art keywords
tumor
locating
positioning
surgery according
locator
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Application number
PCT/CN2019/073803
Other languages
French (fr)
Chinese (zh)
Inventor
陈玉龙
王长利
颜博
胡万宁
刘浩源
郑瑞云
赵晓亮
张真发
张连民
庞冲
王晟广
朱建权
孙晓燕
Original Assignee
唐山哈船科技有限公司
天津市肿瘤医院
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Application filed by 唐山哈船科技有限公司, 天津市肿瘤医院 filed Critical 唐山哈船科技有限公司
Priority to PCT/CN2019/073803 priority Critical patent/WO2020154935A1/en
Priority to AU2019100780A priority patent/AU2019100780A4/en
Publication of WO2020154935A1 publication Critical patent/WO2020154935A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/02—Devices for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
    • A61B6/03—Computerised tomographs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/10—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges for stereotaxic surgery, e.g. frame-based stereotaxis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy

Definitions

  • the invention relates to the technical field of surgical auxiliary equipment, in particular to a device for positioning tumors after surgery.
  • Tumors refer to new organisms formed by the proliferation of local tissue cells under the action of various tumor-causing factors; tumors are roughly divided into benign tumors and malignant tumors (i.e. cancer). Benign tumors are usually removed by surgery, and malignant tumors are treated comprehensively. If it is necessary to combine radiotherapy and chemotherapy, in order to greatly increase the cure rate and improve the quality of life of patients.
  • the present invention proposes a device for positioning a tumor after surgery, which is conveniently placed near the tumor and quickly and accurately locates the position of the tumor.
  • a device for positioning a tumor after surgery comprising an internal positioner and an external positioner, the internal positioner includes an expandable compression body and a positioning body, the compression body Wrap the positioning body; the external positioner includes a three-dimensional coordinate device.
  • the internal positioner further includes a shell, the shell covers the compressed body; the shell ablates after being in contact with body fluids for 5-10 minutes.
  • compression body and the positioning body are an integral structure.
  • the compressed body is made of swelling material, and the volume expands by 5 to 10 times after being in contact with body fluid for 5 seconds to 30 minutes.
  • the compressed body is an elastic metal wire ball.
  • the positioning body is made of magnetic metal material.
  • the shell is ribbon-shaped and binds the compression body.
  • the internal positioner has a spindle shape with a maximum outer diameter of 0.5-5 mm.
  • the swelling material is one or more of polyacrylic acid, sodium polyacrylate, polyvinyl alcohol, sodium alginate, agar, or polysaccharide hydrogel.
  • the shell is made of gelatin or starch.
  • the shell includes a tracer, which is released into the surrounding tissue when the shell is ablated.
  • the three-dimensional coordinate device includes two vertical scales, and the scales are provided with mutually perpendicular scale lines.
  • the scale is made of plastic, and the scale line is a metal wire.
  • the present invention has the following advantages: the dual positioning function of the internal locator combined with the external locator can be used to quickly and accurately locate the tumor position in the postoperative tissue, which is convenient for doctors to accurately collect tumor slices for pathological analysis. The time from resection to confirming the nature of the tumor is shortened, and the pain of the patient and the pressure and workload of the doctor's operation are reduced.
  • the inner locator product of the present invention can be covered with a shell structure.
  • the shell covers the compression body to prevent the compression body from expanding.
  • the shell itself is made of ablative material and inserted into the vicinity of the tumor. After contact with body fluids, the shell ablates and compresses The body just started to expand.
  • the locator product can be made into a shape that can be inserted into the vicinity of the tumor through a hollow needle. It will not cause too much pain to the patient before the operation, and it is accurate and reliable.
  • the structure of the whole product is ingenious. It is convenient and fast to inject the internal locator before the operation. Combined with the external locator after the operation, it is helpful for the accurate positioning of the tumor in the excised tissue, convenient, fast and accurate positioning of the tumor location, and shorten the time for pathological analysis of the slice.
  • Figure 1 is a schematic diagram of the structure of the device for locating tumors after surgery of the present invention
  • Figure 2 is a schematic diagram of the internal positioner
  • Figure 3 is a schematic diagram of the compressed body after expansion
  • Figure 4 is another structural schematic diagram of the internal positioner
  • Figure 5 is a third structural diagram of the internal positioner
  • 1-internal locator 11-compression body, 12-positioning body, 13-housing, 2-outer locator, 21-wire.
  • the device for locating the tumor after the operation of the present invention is a positioning device suitable for placing part of the components near the tumor before the operation, and convenient for detecting and accurately determining the position of the tumor in the resected tissue after the tumor is surgically removed.
  • the device for locating a tumor after surgery includes two locators: an internal locator 1 and an external locator 2.
  • the internal locator 1 is placed near the tumor before surgery and is removed with the tumor during the operation.
  • the internal locator 1 includes a Expanded compression body 11 and positioning body 12, said compression body 11 envelops said positioning body 12.
  • the compression body 11 is in a compressed state, and is covered with a positioning body 12 inside. It is sent to the vicinity of the tumor before the operation, especially when at least three internal locators 1 are placed near the tumor, which can more accurately define the position of the tumor.
  • the external locator 2 belongs to a three-dimensional three-dimensional locator, which is used to locate the spatial position of the tumor in the resected tissue after the operation, so as to facilitate timely and accurate understanding of the tumor.
  • the internal locator 1 is inserted into the tissue near the tumor, and the compression body 11 will automatically expand. Even for the lungs that collapsed during the operation, the expansion makes the tumor position more obvious; at the same time, the locating body covered in the expanded compression body 11 12.
  • the positioning can also be detected by instruments (such as CT), so that the position determination is more accurate, which is convenient for the doctor to quickly find the tumor and perform resection, which reduces the patient's operation time and greatly reduces the pressure during the operation of the doctor.
  • a device for locating a tumor after surgery is composed of an internal locator 1 and an external locator 2.
  • the internal locator 1 is suitable for being placed in the tissue near the tumor before surgery for easy reference Locate the tumor location; therefore, you can set multiple in the tissue near the tumor, which is more conducive to tumor location.
  • the internal positioner 1 itself can be set to have a very small volume, and the hollow needle injection method can be used to inject into the tissue near the tumor, so as to minimize the harm to the patient and facilitate the operation.
  • the internal positioner 1 is composed of an outer compressed body 11 and an internal positioning body 12.
  • the compressed body 11 is made of swelling material and has a small volume before contact with liquid. It covers the positioning body 12 and is injected by a hollow needle. To the vicinity of the tumor.
  • the swelling material absorbs body fluids and expands and changes in volume, as shown in Figure 2.
  • the swelling material As to how long the body fluids contact with the body fluid, and how much the volume expands, it can be selected according to different swelling materials and surgical needs; Generally, it is set to expand by 5 to 10 times after being in contact with body fluids for 5 seconds to 30 minutes to meet the needs of surgery.
  • the swelling material is one or more of polyacrylic acid, sodium polyacrylate, polyvinyl alcohol, sodium alginate, agar, or polysaccharide hydrogel.
  • the above substances are all conventional swelling materials, that is, they can increase in volume after absorbing water.
  • the compressed body 11 After the volume of the compressed body 11 increases, it can squeeze the surrounding tissues to be more firmly located beside the tumor. Even if the tissue around the tumor changes, such as collapse, the compressed body 11 after expansion does not change, so it is relatively The positioning information is more reliable. In particular, there are multiple compressed bodies 11 distributed near the tumor, such as the front, back, left, right, upper, and lower positions of the tumor, and the positioning accuracy will be very high.
  • the position of the positioning body 12 can be determined by instrument detection, so that the approximate position of the tumor can be accurately known on the detection instrument, and the tissue including the tumor and all the compression bodies 11 are directly integrated during the operation. Resection ensures the completeness of the tumor removal, and there will be no remaining problems without complete removal.
  • CT can be used for instrument detection. Since CT is sensitive to metal, the positioning body 12 here is made of metal, so the CT detection is very easy to determine the position of the positioning body 12.
  • the positioning body 12 itself can be in the shape of particles, wires, sheets, etc. made of metal, which can achieve the above positioning effect.
  • the shape of the device for positioning the tumor after the operation is spindle-shaped. Since the hollow needle injection method is used to set it next to the tumor, the maximum outer diameter is set to 0.5-5 mm. The size of the device for positioning the tumor after the operation is selected according to the size of the tumor. .
  • the external locator 2 is used to detect the tissue containing tumor after removal. Because the tissue contains the internal locator 1, especially when X-ray is irradiated, several internal locators 1 can clearly show their respective positions. The location is used as a reference to accurately determine the location of the tumor.
  • the external locator 2 is a three-dimensional positioning structure, as shown in Figure 1 two vertical scales, each of which is provided with a vertical scale 21, especially the scale is made of plastic, the scale 21 is It is made of metal wire, and the removed tissue is placed on a dial of the external locator 2, and the position parameters of the internal locator 1 on the external locator 2 can be determined by top-view irradiation and side-view irradiation, thereby further determining The location parameters of the tumor.
  • the compressed body 11 is covered with a shell 13 which ablates after being in contact with body fluids for 5-10 minutes.
  • the shell includes a tracer, which is released into the surrounding tissue when the shell is ablated, and is used to mark the location of the tissue.
  • a tracer for example, nuclides, methylene blue and nanocarbons.
  • the positron annihilation produced during the decay process of the radionuclide is subjected to electronic detection and computer reconstruction imaging, so that we can obtain human metabolism or functional images.
  • a shell 13 is provided outside the compression body 11 to suspend the expansion of the compression body 11; the compression body 11 can only be expanded when the shell 13 ablates to the extent that the compression body 11 cannot be restricted.
  • the structure of adding a shell 13 outside the compression body 11 can relieve the patient's pain after the hollow needle is injected into the positioner, and prevent the patient from being injured by the rapid expansion of the compression body 11 immediately after the injection.
  • the compressed body 11 is not only limited to an expandable material, but can also be made of an elastic material or other expandable materials.
  • the casing 13 temporarily restricts the expansion of the compression body 11. As shown in FIG. 4, the casing 13 is fully enclosed to cover the compression body 11. At this time, the compression body 11 is made of swelling material to avoid the casing 13 The compression body 11 starts to expand without ablation to a certain extent.
  • a covering that can limit the expansion of the compression body 11 at the key position can be used, such as a compression body made of elastic material, and the outer shell 13 is set to be linear, and the compression body 11 to be expanded can be wound.
  • the outer shell 13 is made of gelatin or starch. After being in contact with body fluids, it will gradually melt and cause no harm to the human body.
  • the internal positioner 1 is compared with the product in Example 1.
  • the compression body 11 and the positioning body 12 are integrated, which is equivalent to the positioning body 12 having an expansion function, or the compression body 11 has a positioning function, such as compression After the wire ball.
  • a tiny compressed metal wire ball is injected into the vicinity of the tumor through a hollow needle, and it immediately expands to form an expanded locator; a shell 13 can also be added outside the compression body 11, as shown in Figure 5, after the injection, the shell 13 will ablate to a certain extent After the degree, the metal wire ball expands.
  • the shell includes a tracer, which is released into the surrounding tissue when the shell is ablated, and is used to mark the location of the tissue. For example, nuclides, methylene blue and nanocarbons.
  • the positron annihilation produced during the decay process of the radionuclide is subjected to electronic detection and computer reconstruction imaging, so that we can obtain human metabolism or functional images.
  • the shell 13 can be made into a ribbon shape, and the metal wire ball can be tied up. When the ribbon-shaped shell 13 contacts the body fluid, ablation occurs until the metal wire ball expands.
  • the housing 13 can be set in a spindle shape, a round ball or other shapes convenient for injection.
  • the positioning body 2 in the internal positioner 1 is made of metal, and it can also be made of magnetic metal materials, such as iron-cobalt, nickel and their alloys. It is convenient for the instrument to detect by using magnetic detection equipment to avoid metal Interference itself in surgery.
  • the device for locating the tumor after the operation of the present invention passes through a hollow needle before the operation.
  • the internal locator 1 is placed next to the tumor in the lung, and the lung collapse becomes very small after the breathing device is inserted during the operation.
  • the original tumor is not easy to locate and remove.
  • the internal locator 1 placed next to the tumor can accurately locate the tumor and perform the resection.
  • After the resection combine with the external locator 2 to find the tumor (in traditional operations, it is difficult to find the tumor in the cut tissue. Even CT is difficult), do rapid pathology, reduce operation time, protect patients, and reduce the workload of doctors.

Abstract

Disclosed is a device for locating a tumour after surgery. The device comprises an internal locator (1) and an external locator (2), wherein the internal locator (1) comprises an expandable compressed body (11) and a locating body (12), with the compressed body (11) enclosing the locating body (12); and the external locator (2) comprises a three-dimensional coordinate machine. The entire device has an ingenious structure. The internal locator (1) is easily and rapidly implanted before surgery, and facilitates the accurate locating of a tumour in resected tissue in combination with the external locator (2) after the surgery, in order to easily, rapidly and accurately locate the tumour, thus reducing the time needed for pathological analysis of a section.

Description

术后定位肿瘤的装置Device for positioning tumor after operation 技术领域Technical field
本发明涉及手术辅助设备技术领域，尤其是一种术后定位肿瘤的装置。The invention relates to the technical field of surgical auxiliary equipment, in particular to a device for positioning tumors after surgery.
背景技术Background technique
肿瘤是指机体在各种致瘤因子作用下，局部组织细胞增生所形成的新生物；肿瘤大致分为良性肿瘤和恶性肿瘤(即癌)，良性肿瘤通常通过手术切除，恶性肿瘤进行综合治疗，如需要结合放化疗，以期较大幅度地提高治愈率，并改善患者的生活质量。Tumors refer to new organisms formed by the proliferation of local tissue cells under the action of various tumor-causing factors; tumors are roughly divided into benign tumors and malignant tumors (i.e. cancer). Benign tumors are usually removed by surgery, and malignant tumors are treated comprehensively. If it is necessary to combine radiotherapy and chemotherapy, in order to greatly increase the cure rate and improve the quality of life of patients.
手术切除治疗过程中，由于肿瘤本身是非常微小的，需要术前能准确定位肿瘤位置，方便摘除包含肿瘤的部分组织。但在实际操作中，通常对肿瘤的定位是通过CT进行，但对于手术切除后的组织，大多发生萎缩现象，此时再想确认肿瘤的位置，哪怕是通过CT扫描，也无法得出准确的位置信息。这必然造成手术后的肿瘤的病理检测时间相应较长。During surgical resection, because the tumor itself is very small, it is necessary to accurately locate the tumor location before surgery to facilitate the removal of part of the tissue containing the tumor. However, in actual operation, the location of the tumor is usually performed by CT, but for the tissue after surgical resection, most of the atrophy occurs. At this time, if you want to confirm the location of the tumor, even through CT scan, it is impossible to get an accurate location information. This will inevitably lead to a correspondingly longer time for pathological detection of tumors after surgery.
面对目前环境污染，肿瘤甚至癌症的发病率逐年增加，无论是为了减轻病人承受手术的痛苦时间，还是减轻医生手术操作的压力，研发一种能快速定位术后组织中肿瘤位置的设备，是非常必要的。Faced with the current environmental pollution, the incidence of tumors and even cancers is increasing year by year. Whether it is to reduce the painful time of patients undergoing surgery, or to reduce the pressure of doctors' surgical operations, the development of a device that can quickly locate the tumor location in the postoperative tissue is very necessary.
发明内容Summary of the invention
本发明针对现有技术的不足，提出一种术后定位肿瘤的装置，方便置于肿瘤附近，对肿瘤位置进行快速准确的定位。Aiming at the deficiencies of the prior art, the present invention proposes a device for positioning a tumor after surgery, which is conveniently placed near the tumor and quickly and accurately locates the position of the tumor.
为了实现上述发明目的，本发明提供以下技术方案：一种术后定位肿瘤的装置，包括内部***和外部***，所述内部***包括可扩张的压缩体和定位体，所述压缩体包覆住所述定位体；所述外部***包括三维坐标 器。In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions: a device for positioning a tumor after surgery, comprising an internal positioner and an external positioner, the internal positioner includes an expandable compression body and a positioning body, the compression body Wrap the positioning body; the external positioner includes a three-dimensional coordinate device.
进一步地，所述内部***还包括有外壳，所述外壳包覆住所述压缩体；所述外壳在与体液接触5～10分钟后消融。Further, the internal positioner further includes a shell, the shell covers the compressed body; the shell ablates after being in contact with body fluids for 5-10 minutes.
进一步地，所述压缩体和所述定位体为一体结构。Further, the compression body and the positioning body are an integral structure.
进一步地，所述压缩体为溶胀材料制成，与体液接触5秒～30分钟后体积膨胀5～10倍。Further, the compressed body is made of swelling material, and the volume expands by 5 to 10 times after being in contact with body fluid for 5 seconds to 30 minutes.
进一步地，所述压缩体为弹性金属丝球。Further, the compressed body is an elastic metal wire ball.
进一步地，所述定位体为磁性金属材质制成。Further, the positioning body is made of magnetic metal material.
进一步地，所述外壳为丝带状，绑扎住所述压缩体。Further, the shell is ribbon-shaped and binds the compression body.
进一步地，所述内部***为纺锤状，最大外径为0.5～5mm。Further, the internal positioner has a spindle shape with a maximum outer diameter of 0.5-5 mm.
进一步地，所述溶胀材料为聚丙烯酸、聚丙烯酸钠、聚乙烯醇、海藻酸钠、琼脂或多糖水凝胶中一种或多种。Further, the swelling material is one or more of polyacrylic acid, sodium polyacrylate, polyvinyl alcohol, sodium alginate, agar, or polysaccharide hydrogel.
进一步地，所述外壳由明胶或淀粉制成。Further, the shell is made of gelatin or starch.
进一步地，所述外壳中包括示踪剂，在所述外壳消融时释放到周围组织中。Further, the shell includes a tracer, which is released into the surrounding tissue when the shell is ablated.
进一步地，所述三维坐标器包括垂直设置的两个刻度盘，所述刻度盘上设有相互垂直的刻度线。Further, the three-dimensional coordinate device includes two vertical scales, and the scales are provided with mutually perpendicular scale lines.
进一步地，所述刻度盘为塑料制品，所述刻度线为金属丝。Further, the scale is made of plastic, and the scale line is a metal wire.
与现有技术相比，本发明具有以下优点：利用内***结合外***双重定位功能，对术后组织中肿瘤位置进行快速准确定位，方便医生准确采集到肿瘤切片，进行病理分析，大大缩短了切除至确认肿瘤性质的时间，减轻病人痛苦以及医生手术压力和工作量。Compared with the prior art, the present invention has the following advantages: the dual positioning function of the internal locator combined with the external locator can be used to quickly and accurately locate the tumor position in the postoperative tissue, which is convenient for doctors to accurately collect tumor slices for pathological analysis. The time from resection to confirming the nature of the tumor is shortened, and the pain of the patient and the pressure and workload of the doctor's operation are reduced.
本发明的内***产品外可包覆一层外壳结构，外壳包覆住压缩体，防止压缩体扩张，而外壳本身为消融材料制成，塞入肿瘤附近，与体液接触后外壳消融，压缩体才开始扩张。被***产品可制成通过空心针就能塞入肿 瘤附近的形状，术前也不会对病人造成太大的痛苦，而且准确可靠。The inner locator product of the present invention can be covered with a shell structure. The shell covers the compression body to prevent the compression body from expanding. The shell itself is made of ablative material and inserted into the vicinity of the tumor. After contact with body fluids, the shell ablates and compresses The body just started to expand. The locator product can be made into a shape that can be inserted into the vicinity of the tumor through a hollow needle. It will not cause too much pain to the patient before the operation, and it is accurate and reliable.
整个产品的结构巧妙，术前注入内***，方便快速，术后结合外***，有助于切除组织中肿瘤的准确定位，方便快速准确地定位肿瘤位置，缩短切片做病理分析的时间。The structure of the whole product is ingenious. It is convenient and fast to inject the internal locator before the operation. Combined with the external locator after the operation, it is helpful for the accurate positioning of the tumor in the excised tissue, convenient, fast and accurate positioning of the tumor location, and shorten the time for pathological analysis of the slice.
附图说明Description of the drawings
为了更清楚地说明本发明实施例或现有技术中的技术方案，下面将对实施例或现有技术描述中所需要使用的附图作简单地介绍，显而易见地，下面描述中的附图仅仅是本发明的一些实施例，对于本领域普通技术人员来讲，在不付出创造性劳动的前提下，还可以根据这些附图示出的结构获得其他的附图。In order to explain the embodiments of the present invention or the technical solutions in the prior art more clearly, the following will briefly introduce the drawings that need to be used in the description of the embodiments or the prior art. Obviously, the drawings in the following description are only These are some embodiments of the present invention. For those of ordinary skill in the art, without creative work, other drawings can be obtained based on the structure shown in these drawings.
图1为本发明术后定位肿瘤的装置的结构示意图；Figure 1 is a schematic diagram of the structure of the device for locating tumors after surgery of the present invention;
图2为内部***的结构示意图；Figure 2 is a schematic diagram of the internal positioner;
图3为压缩体膨胀后的示意图；Figure 3 is a schematic diagram of the compressed body after expansion;
图4为内部***的另一结构示意图；Figure 4 is another structural schematic diagram of the internal positioner;
图5为内部***的第三个结构示意图；Figure 5 is a third structural diagram of the internal positioner;
图示标记：Icon mark:
1-内部***、11-压缩体、12-定位体、13-外壳、2-外部***、21-金属丝。1-internal locator, 11-compression body, 12-positioning body, 13-housing, 2-outer locator, 21-wire.
具体实施方式detailed description
下面将结合本发明实施例中的附图，对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明的一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative work shall fall within the protection scope of the present invention.
需要说明，若本发明实施例中有涉及方向性指示(诸如上、下、左、右、前、后……)，则该方向性指示仅用于解释在某一特定姿态(如附图所示)下各部件之间的相对位置关系、运动情况等，如果该特定姿态发生改变时，则该方向性指示也相应地随之改变。It should be noted that if there is a directional indication (such as up, down, left, right, front, back...) in the embodiment of the present invention, the directional indication is only used to explain that it is in a specific posture (as shown in the drawings). If the specific posture changes, the relative positional relationship, movement, etc. of the various components will also change accordingly.
另外，各个实施例之间的技术方案可以相互结合，但是必须是以本领域普通技术人员能够实现为基础，当技术方案的结合出现相互矛盾或无法实现时应当认为这种技术方案的结合不存在，也不在本发明要求的保护范围之内。In addition, the technical solutions between the various embodiments can be combined with each other, but they must be based on what can be achieved by those of ordinary skill in the art. When the combination of technical solutions conflicts or cannot be achieved, it should be considered that such a combination of technical solutions does not exist. , Is not within the protection scope of the present invention.
本发明术后定位肿瘤的装置，是适用于手术前部分器件放置于肿瘤附近，手术摘除肿瘤后方便检测和准确确定肿瘤在切除的组织中位置的定位设备。The device for locating the tumor after the operation of the present invention is a positioning device suitable for placing part of the components near the tumor before the operation, and convenient for detecting and accurately determining the position of the tumor in the resected tissue after the tumor is surgically removed.
该术后定位肿瘤的装置，包括两个***：内部***1和外部***2，内部***1为术前置于肿瘤附近，手术中随同肿瘤一起被摘除，内部***1包括可扩张的压缩体11和定位体12，所述压缩体11包覆住所述定位体12。压缩体11处于紧缩状态，内部包覆有定位体12，在术前被送至肿瘤附近，尤其是在肿瘤附近至少放置三个该内部***1，更能准确限定肿瘤位置。The device for locating a tumor after surgery includes two locators: an internal locator 1 and an external locator 2. The internal locator 1 is placed near the tumor before surgery and is removed with the tumor during the operation. The internal locator 1 includes a Expanded compression body 11 and positioning body 12, said compression body 11 envelops said positioning body 12. The compression body 11 is in a compressed state, and is covered with a positioning body 12 inside. It is sent to the vicinity of the tumor before the operation, especially when at least three internal locators 1 are placed near the tumor, which can more accurately define the position of the tumor.
外部***2属于立体三维***，使用于术后肿瘤在切除组织中的空间位置的定位，方便及时准确地了解到肿瘤。The external locator 2 belongs to a three-dimensional three-dimensional locator, which is used to locate the spatial position of the tumor in the resected tissue after the operation, so as to facilitate timely and accurate understanding of the tumor.
内部***1塞入肿瘤附近的组织中，压缩体11会自动扩张，即使针对手术中塌缩的肺部，该扩张使得肿瘤位置较为明显；同时包覆在扩张后压缩体11中的定位体12，也可通过仪器(如CT)检测定位，从而位置确定更为精准，方便医生快速找到肿瘤，进行切除，这样减少病人手术时间，医生手术操作过程中的压力也大大降低。The internal locator 1 is inserted into the tissue near the tumor, and the compression body 11 will automatically expand. Even for the lungs that collapsed during the operation, the expansion makes the tumor position more obvious; at the same time, the locating body covered in the expanded compression body 11 12. The positioning can also be detected by instruments (such as CT), so that the position determination is more accurate, which is convenient for the doctor to quickly find the tumor and perform resection, which reduces the patient's operation time and greatly reduces the pressure during the operation of the doctor.
实施例1Example 1
如图1、2和3所示，一种术后定位肿瘤的装置，由内部***1和外部***2构成，内部***1适用于在术前置于肿瘤附近组织中，便于参考 性定位肿瘤位置；因此可在肿瘤附近组织中设置多个，更有利于定位肿瘤。同时内部***1本身可设为体积非常小，采用空心针注射方式注射至肿瘤附近的组织中即可，这样对病人伤害最小，有利于手术进行。As shown in Figures 1, 2 and 3, a device for locating a tumor after surgery is composed of an internal locator 1 and an external locator 2. The internal locator 1 is suitable for being placed in the tissue near the tumor before surgery for easy reference Locate the tumor location; therefore, you can set multiple in the tissue near the tumor, which is more conducive to tumor location. At the same time, the internal positioner 1 itself can be set to have a very small volume, and the hollow needle injection method can be used to inject into the tissue near the tumor, so as to minimize the harm to the patient and facilitate the operation.
其中内部***1由外层的压缩体11和内部的定位体12组成，该压缩体11为溶胀材料制成，在未接触液体前体积很小，包覆住定位体12，由空心针注射至肿瘤附近。The internal positioner 1 is composed of an outer compressed body 11 and an internal positioning body 12. The compressed body 11 is made of swelling material and has a small volume before contact with liquid. It covers the positioning body 12 and is injected by a hollow needle. To the vicinity of the tumor.
压缩体11接触到体液后，溶胀材料吸收体液发生膨胀变化，体积增大，如图2所示；对于与体液接触多久发生膨胀，以及体积膨胀多大，可根据溶胀材料不同结合手术需要进行选择；一般设定其与体液接触5秒～30分钟后体积膨胀5～10倍，满足手术需要即可。After the compressed body 11 comes into contact with body fluids, the swelling material absorbs body fluids and expands and changes in volume, as shown in Figure 2. As to how long the body fluids contact with the body fluid, and how much the volume expands, it can be selected according to different swelling materials and surgical needs; Generally, it is set to expand by 5 to 10 times after being in contact with body fluids for 5 seconds to 30 minutes to meet the needs of surgery.
其中溶胀材料为聚丙烯酸、聚丙烯酸钠、聚乙烯醇、海藻酸钠、琼脂或多糖水凝胶中一种或多种。上述物质均为常规的溶胀材料，即吸水后能发生体积增大变化。The swelling material is one or more of polyacrylic acid, sodium polyacrylate, polyvinyl alcohol, sodium alginate, agar, or polysaccharide hydrogel. The above substances are all conventional swelling materials, that is, they can increase in volume after absorbing water.
压缩体11体积增大后，对周围的组织进行挤压，能更稳固地位于肿瘤旁，即使肿瘤旁的组织发生变化，如塌缩，膨胀后的压缩体11是不发生变化的，因此相对定位信息较为可靠。尤其是该压缩体11设有多个，分布在肿瘤附近，如肿瘤的前、后、左、右、上、下等位置，该定位的准确度会非常高。After the volume of the compressed body 11 increases, it can squeeze the surrounding tissues to be more firmly located beside the tumor. Even if the tissue around the tumor changes, such as collapse, the compressed body 11 after expansion does not change, so it is relatively The positioning information is more reliable. In particular, there are multiple compressed bodies 11 distributed near the tumor, such as the front, back, left, right, upper, and lower positions of the tumor, and the positioning accuracy will be very high.
再结合压缩体11内的定位体12，可通过仪器检测来确定定位体12的位置，从而在检测仪器上准确知晓肿瘤的大致位置，手术时直接将包含肿瘤及所有压缩体11的组织一并切除，确保肿瘤摘除的完整程度，不会出现残留而没摘除完全的问题。Combined with the positioning body 12 in the compression body 11, the position of the positioning body 12 can be determined by instrument detection, so that the approximate position of the tumor can be accurately known on the detection instrument, and the tissue including the tumor and all the compression bodies 11 are directly integrated during the operation. Resection ensures the completeness of the tumor removal, and there will be no remaining problems without complete removal.
仪器检测可采用传统的CT，由于CT对金属反应敏感，这里的定位体12采用金属材质，因此CT检测非常容易确定定位体12的位置。Conventional CT can be used for instrument detection. Since CT is sensitive to metal, the positioning body 12 here is made of metal, so the CT detection is very easy to determine the position of the positioning body 12.
定位体12本身可为金属制成的颗粒、线、片等等形状，都能达到上述定位效果。The positioning body 12 itself can be in the shape of particles, wires, sheets, etc. made of metal, which can achieve the above positioning effect.
本实施例中，术后定位肿瘤的装置的外形为纺锤状，由于采用空心针注射方式设在肿瘤旁，最大外径设为0.5～5mm，根据肿瘤大小来选择术后定位肿瘤的装置的大小。In this embodiment, the shape of the device for positioning the tumor after the operation is spindle-shaped. Since the hollow needle injection method is used to set it next to the tumor, the maximum outer diameter is set to 0.5-5 mm. The size of the device for positioning the tumor after the operation is selected according to the size of the tumor. .
外部***2用于摘除后包含肿瘤的组织检测，由于该组织中含有内部***1，尤其是通过X光照射时，若干个内部***1能非常明显的显现出各自位置，以这些准确位置作参考，能准确判断出肿瘤的位置。The external locator 2 is used to detect the tissue containing tumor after removal. Because the tissue contains the internal locator 1, especially when X-ray is irradiated, several internal locators 1 can clearly show their respective positions. The location is used as a reference to accurately determine the location of the tumor.
外部***2为三维定位结构，如图1所示的两个相互垂直的刻度盘，每个刻度盘上设有相互垂直的刻度线21，尤其是刻度盘为塑料制成，刻度线21为金属丝制成，摘除后的组织放在外部***2的一个刻度盘上，通过俯视照射和侧视照射，能确定出内部***1在外部***2上的位置参数，从而进一步确定出肿瘤的位置参数。The external locator 2 is a three-dimensional positioning structure, as shown in Figure 1 two vertical scales, each of which is provided with a vertical scale 21, especially the scale is made of plastic, the scale 21 is It is made of metal wire, and the removed tissue is placed on a dial of the external locator 2, and the position parameters of the internal locator 1 on the external locator 2 can be determined by top-view irradiation and side-view irradiation, thereby further determining The location parameters of the tumor.
实施例2Example 2
图4所示的内部***1，与实施例1相比，在压缩体11外包覆有一层外壳13，该外壳13在与体液接触5～10分钟后消融。优选地，所述外壳中包括示踪剂，在所述外壳消融时释放到周围组织中，用于标记所述组织位置。例如，核素类、亚甲蓝类和纳米碳类。例如，经核素标记的示踪剂注入人体后，核素衰变过程中产生的正电子湮灭通过电子检测和计算机重构成像，使我们可以得到人体代谢或功能图像。In the internal positioner 1 shown in Fig. 4, compared with the first embodiment, the compressed body 11 is covered with a shell 13 which ablates after being in contact with body fluids for 5-10 minutes. Preferably, the shell includes a tracer, which is released into the surrounding tissue when the shell is ablated, and is used to mark the location of the tissue. For example, nuclides, methylene blue and nanocarbons. For example, after a radionuclide-labeled tracer is injected into the human body, the positron annihilation produced during the decay process of the radionuclide is subjected to electronic detection and computer reconstruction imaging, so that we can obtain human metabolism or functional images.
在压缩体11外设置一层外壳13，可暂停压缩体11扩张；必须等外壳13消融至不能限制住压缩体11时，压缩体11才能扩张。A shell 13 is provided outside the compression body 11 to suspend the expansion of the compression body 11; the compression body 11 can only be expanded when the shell 13 ablates to the extent that the compression body 11 cannot be restricted.
在压缩体11外增设外壳13的结构，在空心针注射本***后能减轻病人痛苦，避免刚注射后压缩体11的快速扩张对病人的伤害。The structure of adding a shell 13 outside the compression body 11 can relieve the patient's pain after the hollow needle is injected into the positioner, and prevent the patient from being injured by the rapid expansion of the compression body 11 immediately after the injection.
本实施例内部***1产品中，压缩体11不仅仅限制为膨胀材料，还可用弹性材料制成，或其它可扩张材料。In the product of the internal positioner 1 of this embodiment, the compressed body 11 is not only limited to an expandable material, but can also be made of an elastic material or other expandable materials.
外壳13对压缩体11的扩张起到暂时限制的作用，图4中所示的为外壳13为全包围式包覆住压缩体11，此时压缩体11为溶胀材料制成的，避免外壳13未消融到一定程度而压缩体11开始扩张。The casing 13 temporarily restricts the expansion of the compression body 11. As shown in FIG. 4, the casing 13 is fully enclosed to cover the compression body 11. At this time, the compression body 11 is made of swelling material to avoid the casing 13 The compression body 11 starts to expand without ablation to a certain extent.
在实际制作中，可采用能限制压缩体11扩张的关键位置的包覆，如弹性材料制成的压缩体，外壳13壳设为线状，缠绕住待扩张的压缩体11即可。In actual production, a covering that can limit the expansion of the compression body 11 at the key position can be used, such as a compression body made of elastic material, and the outer shell 13 is set to be linear, and the compression body 11 to be expanded can be wound.
外壳13采用明胶或淀粉等制成，与体液接触后，会逐渐消融，对人体不造成伤害。The outer shell 13 is made of gelatin or starch. After being in contact with body fluids, it will gradually melt and cause no harm to the human body.
实施例3Example 3
如图5所示的内部***1，与实施例1产品相比，压缩体11和定位体12为一体结构，相当于定位体12带有扩张功能，或压缩体11具有定位功能，如压缩后的金属丝球。As shown in Fig. 5, the internal positioner 1 is compared with the product in Example 1. The compression body 11 and the positioning body 12 are integrated, which is equivalent to the positioning body 12 having an expansion function, or the compression body 11 has a positioning function, such as compression After the wire ball.
微小的压缩状金属丝球，经空心针注射至肿瘤附近，立即发生膨胀，形成膨胀的***；也可在压缩体11外增设外壳13，图5所示，注射后待外壳13消融到一定程度后，金属丝球发生膨胀。优选地，所述外壳中包括示踪剂，在所述外壳消融时释放到周围组织中，用于标记所述组织位置。例如，核素类、亚甲蓝类和纳米碳类。例如，经核素标记的示踪剂注入人体后，核素衰变过程中产生的正电子湮灭通过电子检测和计算机重构成像，使我们可以得到人体代谢或功能图像。A tiny compressed metal wire ball is injected into the vicinity of the tumor through a hollow needle, and it immediately expands to form an expanded locator; a shell 13 can also be added outside the compression body 11, as shown in Figure 5, after the injection, the shell 13 will ablate to a certain extent After the degree, the metal wire ball expands. Preferably, the shell includes a tracer, which is released into the surrounding tissue when the shell is ablated, and is used to mark the location of the tissue. For example, nuclides, methylene blue and nanocarbons. For example, after a radionuclide-labeled tracer is injected into the human body, the positron annihilation produced during the decay process of the radionuclide is subjected to electronic detection and computer reconstruction imaging, so that we can obtain human metabolism or functional images.
对于压缩状态的金属丝球，外壳13可设为丝带状，绑扎住金属丝球即可，等丝带状外壳13接触体液，发生消融至金属丝球发生扩张。For the compressed metal wire ball, the shell 13 can be made into a ribbon shape, and the metal wire ball can be tied up. When the ribbon-shaped shell 13 contacts the body fluid, ablation occurs until the metal wire ball expands.
外壳13可设为纺锤状、圆球或其它便于注射的形状。The housing 13 can be set in a spindle shape, a round ball or other shapes convenient for injection.
上述所有实施例中，内部***1中定位体2采用金属制作，还可设为磁性金属材质制作，如铁钴、镍及其合金，方便仪器检测时可采用磁性探测设备检测，这样避免金属本身在术中的干扰。In all the above embodiments, the positioning body 2 in the internal positioner 1 is made of metal, and it can also be made of magnetic metal materials, such as iron-cobalt, nickel and their alloys. It is convenient for the instrument to detect by using magnetic detection equipment to avoid metal Interference itself in surgery.
本发明术后定位肿瘤的装置在术前通过空心针，以肺部肿瘤切除为例，将内部***1放在肺内的肿瘤旁边，手术中***呼吸装置后肺部塌缩变得非常小，原肿瘤不易定位切除，通过放在肿瘤旁的内部***1能准确定位肿瘤，进行切除，切除后再结合外部***2将肿瘤找到(传统操作中，切下的组织很难找到肿瘤，甚至CT也很难)，做快速病理，减少手术时间，保护病人，减轻医生工作量。The device for locating the tumor after the operation of the present invention passes through a hollow needle before the operation. Taking lung tumor resection as an example, the internal locator 1 is placed next to the tumor in the lung, and the lung collapse becomes very small after the breathing device is inserted during the operation. The original tumor is not easy to locate and remove. The internal locator 1 placed next to the tumor can accurately locate the tumor and perform the resection. After the resection, combine with the external locator 2 to find the tumor (in traditional operations, it is difficult to find the tumor in the cut tissue. Even CT is difficult), do rapid pathology, reduce operation time, protect patients, and reduce the workload of doctors.
以上所述仅是本发明的优选实施方式，应当指出，对于本技术领域的普通技术人员来说，在不脱离本发明原理的前提下，还可以做出若干改进和润饰，这些改进和润饰也应视为本发明的保护范围。The above are only the preferred embodiments of the present invention. It should be pointed out that for those of ordinary skill in the art, without departing from the principle of the present invention, several improvements and modifications can be made, and these improvements and modifications are also Should be regarded as the protection scope of the present invention.

Claims (13)

  1. 一种术后定位肿瘤的装置，其特征在于：包括内部***和外部***，所述内部***包括可扩张的压缩体和定位体，所述压缩体包覆住所述定位体；所述外部***包括三维坐标器。A device for locating a tumor after surgery, characterized in that it comprises an internal locator and an external locator, the internal locator includes an expandable compression body and a positioning body, the compression body covers the positioning body; The external positioner includes a three-dimensional coordinater.
  2. 如权利要求1所述术后定位肿瘤的装置，其特征在于：所述内部***还包括有外壳，所述外壳包覆住所述压缩体；所述外壳在与体液接触5～10分钟后消融。The device for locating a tumor after surgery according to claim 1, wherein the internal locator further comprises a shell, and the shell covers the compressed body; the shell is ablated after being in contact with body fluids for 5-10 minutes .
  3. 如权利要求1或2所述术后定位肿瘤的装置，其特征在于：所述压缩体和所述定位体为一体结构。The device for positioning a tumor after surgery according to claim 1 or 2, characterized in that: the compression body and the positioning body are an integral structure.
  4. 如权利要求2所述术后定位肿瘤的装置，其特征在于：所述压缩体为溶胀材料制成，与体液接触5秒～30分钟后体积膨胀5～10倍。The device for locating a tumor after surgery according to claim 2, wherein the compressed body is made of swelling material, and the volume expands by 5 to 10 times after being in contact with body fluid for 5 seconds to 30 minutes.
  5. 如权利要求3所述术后定位肿瘤的装置，其特征在于：所述压缩体为弹性金属丝球。The device for positioning a tumor after surgery according to claim 3, wherein the compressed body is an elastic metal wire ball.
  6. 如权利要求1所述术后定位肿瘤的装置，其特征在于：所述定位体为磁性金属材质制成。The device for positioning a tumor after surgery according to claim 1, wherein the positioning body is made of magnetic metal material.
  7. 如权利要求2所述术后定位肿瘤的装置，其特征在于：所述外壳为丝带状，绑扎住所述压缩体。The device for locating a tumor after surgery according to claim 2, wherein the shell is ribbon-shaped and binds the compression body.
  8. 如权利要求1所述术后定位肿瘤的装置，其特征在于：所述内部***为纺锤状，最大外径为0.5～5mm。The device for locating a tumor after surgery according to claim 1, wherein the internal locator has a spindle shape with a maximum outer diameter of 0.5-5 mm.
  9. 如权利要求4所述术后定位肿瘤的装置，其特征在于：所述溶胀材料为聚丙烯酸、聚丙烯酸钠、聚乙烯醇、海藻酸钠、琼脂或多糖水凝胶中一种或多种。The device for positioning a tumor after surgery according to claim 4, wherein the swelling material is one or more of polyacrylic acid, sodium polyacrylate, polyvinyl alcohol, sodium alginate, agar or polysaccharide hydrogel.
  10. 如权利要求2所述术后定位肿瘤的装置，其特征在于：所述外壳由明胶或淀粉制成。The device for locating a tumor after surgery according to claim 2, wherein the outer shell is made of gelatin or starch.
  11. 如权利要求2所述术后定位肿瘤的装置，其特征在于：所述外壳中 包括示踪剂。The device for locating a tumor after surgery according to claim 2, wherein the casing includes a tracer.
  12. 如权利要求1所述术后定位肿瘤的装置，其特征在于：所述三维坐标器包括垂直设置的两个刻度盘，所述刻度盘上设有相互垂直的刻度线。The device for locating a tumor after surgery according to claim 1, wherein the three-dimensional coordinate device comprises two vertical scales, and the scales are provided with mutually perpendicular scale lines.
  13. 如权利要求11所述术后定位肿瘤的装置，其特征在于：所述刻度盘为塑料制品，所述刻度线为金属丝。The device for locating a tumor after surgery according to claim 11, wherein the scale is made of plastic, and the scale is made of metal wire.
PCT/CN2019/073803 2019-01-30 2019-01-30 Device for locating tumour after surgery WO2020154935A1 (en)

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AU2019100780A AU2019100780A4 (en) 2019-01-30 2019-07-18 Post-surgery tumor locating device

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CN1672630A (en) * 2004-03-26 2005-09-28 埃色康内外科股份有限公司 Apparatus and method for marking tissue
CN104540447A (en) * 2012-07-16 2015-04-22 安都磁学有限公司 Magnetic marker for surgical localization
US20160100910A1 (en) * 2005-11-17 2016-04-14 Breast-Med, Inc. Imaging fiducial markers and methods
WO2018097891A1 (en) * 2016-11-23 2018-05-31 Hologic, Inc. Biopsy site marker
CN108378929A (en) * 2018-04-11 2018-08-10 西安卓恰医疗器械有限公司 With locator markers and preparation method thereof made of degradable metal

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1672630A (en) * 2004-03-26 2005-09-28 埃色康内外科股份有限公司 Apparatus and method for marking tissue
US20160100910A1 (en) * 2005-11-17 2016-04-14 Breast-Med, Inc. Imaging fiducial markers and methods
CN104540447A (en) * 2012-07-16 2015-04-22 安都磁学有限公司 Magnetic marker for surgical localization
WO2018097891A1 (en) * 2016-11-23 2018-05-31 Hologic, Inc. Biopsy site marker
CN108378929A (en) * 2018-04-11 2018-08-10 西安卓恰医疗器械有限公司 With locator markers and preparation method thereof made of degradable metal

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