WO2020101597A3 - Capsule compositions comprising tyrosine-kinase inhibitors - Google Patents
Capsule compositions comprising tyrosine-kinase inhibitors Download PDFInfo
- Publication number
- WO2020101597A3 WO2020101597A3 PCT/TR2019/050581 TR2019050581W WO2020101597A3 WO 2020101597 A3 WO2020101597 A3 WO 2020101597A3 TR 2019050581 W TR2019050581 W TR 2019050581W WO 2020101597 A3 WO2020101597 A3 WO 2020101597A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- tyrosine
- kinase inhibitors
- capsule compositions
- compositions
- capsule
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to solid oral pharmaceutical compositions comprising at least one tyrosine-kinase inhibitor (TKI), particularly nilotinib, or a pharmaceutically acceptable salt thereof providing high stability, solubility and patient compliance.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
TR2018/12177 | 2018-08-27 | ||
TR201812177 | 2018-08-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2020101597A2 WO2020101597A2 (en) | 2020-05-22 |
WO2020101597A3 true WO2020101597A3 (en) | 2020-07-02 |
Family
ID=70730583
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/TR2019/050581 WO2020101597A2 (en) | 2018-08-27 | 2019-07-16 | Capsule compositions comprising tyrosine-kinase inhibitors |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2020101597A2 (en) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012174082A1 (en) * | 2011-06-14 | 2012-12-20 | Novartis Ag | Modified release of 4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-n-5-(4-methyl-1h-imidazol-1-yl)-3-(trifluoromethyl)phenyl] benzamide solubilized using organic acids |
WO2017064538A1 (en) * | 2015-10-16 | 2017-04-20 | Nobel Ilac Sanayii Ve Ticaret A.S. | Pharmaceutical compositions of nilotinib hydrochloride |
WO2017158625A1 (en) * | 2016-03-17 | 2017-09-21 | Sun Pharmaceutical Industries Ltd. | Pharmaceutical composition of nilotinib |
-
2019
- 2019-07-16 WO PCT/TR2019/050581 patent/WO2020101597A2/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012174082A1 (en) * | 2011-06-14 | 2012-12-20 | Novartis Ag | Modified release of 4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-n-5-(4-methyl-1h-imidazol-1-yl)-3-(trifluoromethyl)phenyl] benzamide solubilized using organic acids |
WO2017064538A1 (en) * | 2015-10-16 | 2017-04-20 | Nobel Ilac Sanayii Ve Ticaret A.S. | Pharmaceutical compositions of nilotinib hydrochloride |
WO2017158625A1 (en) * | 2016-03-17 | 2017-09-21 | Sun Pharmaceutical Industries Ltd. | Pharmaceutical composition of nilotinib |
Also Published As
Publication number | Publication date |
---|---|
WO2020101597A2 (en) | 2020-05-22 |
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