WO2020071506A1 - Adapter and injection fluid transport method - Google Patents

Adapter and injection fluid transport method

Info

Publication number
WO2020071506A1
WO2020071506A1 PCT/JP2019/039195 JP2019039195W WO2020071506A1 WO 2020071506 A1 WO2020071506 A1 WO 2020071506A1 JP 2019039195 W JP2019039195 W JP 2019039195W WO 2020071506 A1 WO2020071506 A1 WO 2020071506A1
Authority
WO
WIPO (PCT)
Prior art keywords
injection
nozzle
housing
adapter
injection liquid
Prior art date
Application number
PCT/JP2019/039195
Other languages
French (fr)
Japanese (ja)
Inventor
山本　裕三
崇将 鈴木
Original Assignee
株式会社ダイセル
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 株式会社ダイセル filed Critical 株式会社ダイセル
Priority to CN201980065842.6A priority Critical patent/CN112804981A/en
Priority to US17/282,721 priority patent/US11992460B2/en
Priority to EP19869157.8A priority patent/EP3868353A4/en
Priority to JP2020551087A priority patent/JP7148627B2/en
Publication of WO2020071506A1 publication Critical patent/WO2020071506A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/1782—Devices aiding filling of syringes in situ
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2046—Media being expelled from injector by gas generation, e.g. explosive charge
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/10—Tube connectors; Tube couplings
    • A61M2039/1077—Adapters, e.g. couplings adapting a connector to one or several other connectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2209/00—Ancillary equipment
    • A61M2209/04—Tools for specific apparatus
    • A61M2209/045—Tools for specific apparatus for filling, e.g. for filling reservoirs

Definitions

  • the present invention relates to an adapter for transferring an injection liquid from the outside to a syringe, and a method for transferring the injection liquid using the adapter.
  • a needle-free injector can be exemplified as a device for injecting a drug solution or the like into a target area such as a living body.
  • a needle-free injector without an injection needle has been developed due to ease of handling and hygiene.
  • a drug solution pressurized by a drive source such as a compressed gas or a spring is ejected toward a target region, and the drug solution is ejected into the target region using kinetic energy of the drug solution.
  • the configuration has been put to practical use.
  • the injection liquid is sanitarily transferred to the needle-free injector in a preparation stage for using the apparatus. Requires some care.
  • Patent Document 1 discloses a configuration in which a needleless syringe and a vessel are connected using a coupling device to transfer an injection liquid.
  • a needleless syringe is attached to one side of the coupling device, and a vessel is attached to the other side.
  • the injection liquid stored by the needleless syringe is stored in the vessel.
  • the contact surface of the coupling device has a shape following the distal end surface of the needle-free injector, and the orifice of the coupling device faces the orifice of the needle-free injector.
  • the contact surface of the coupling device should prevent the injection liquid from adhering to the distal end surface of the needleless syringe when transferring the injection liquid from the vessel to the needleless syringe in order to suppress the occurrence of various bacteria and the like. Is formed.
  • the distal end of the coupling device is moved so that the distal end surface of the needle-free injector does not come into contact with the injection liquid during the transfer of the injection liquid (to prevent bacteria from growing on the distal end surface of the needle-free injector).
  • the diameter of the orifice is smaller than the diameter of the orifice in the nozzle portion of the needleless syringe.
  • a needle-free injector applies a high pressure to an ejection liquid to eject the ejection liquid toward a target area with its energy. Therefore, the diameter of the orifice is extremely small due to the injection.
  • the orifice diameter on the coupling device side is smaller than the orifice diameter on the needleless syringe side, it is difficult to transfer the injection liquid using the coupling device. It will take a long time. Also, when transferring a very small amount of injection liquid, the injection liquid is difficult to move to the tip of the orifice of the coupling device, so the air around it is also taken in and injected into the needleless syringe. Will be transported.
  • an object of the present invention is to provide a technique capable of suitably transferring an injection liquid from the outside to a needle-free injector in view of the above-described problems.
  • the present invention is configured such that the opening end of the adapter is smaller than the inner diameter of the housing portion and larger than the injection port of the injection nozzle of the injection device, and the injection liquid is dispersed at the time of transfer.
  • the present invention relates to an adapter for transferring the predetermined injection liquid through an injection port of the injection nozzle to an injection device that outputs the predetermined injection liquid from the injection nozzle,
  • a housing that defines a storage section for storing the predetermined injection liquid, the housing being configured to be detachable from the injection device, and the housing being provided in communication with the storage section in the housing;
  • the above-described injection device is for injecting the injection liquid from the injection nozzle to the outside, but it is necessary to transfer the injection liquid from the outside through the injection port of the injection nozzle as a preparation stage in the injection,
  • the adapter of the present invention is used for transferring such an injection liquid to an injection device.
  • the adapter may be attached to the injection device itself, or alternatively, may be attached to a component constituting the injection device.
  • an adapter configured to be attached to the component is understood to be an adapter attached to the injection device as long as the component forms a part of the injection device.
  • the injection device is not limited to a specific mode regarding the injection of the injection liquid.
  • the energy for pressurizing the injection liquid transferred via the adapter for injection is energy generated chemically, for example, combustion energy generated by an oxidation reaction of explosives, explosives, and the like. You may.
  • the energy for pressurization may be generated electrically, and may be, for example, energy due to a piezoelectric element or an electromagnetic actuator driven by input power.
  • the energy for pressurization may be physically generated, and may be, for example, elastic energy by an elastic body or internal energy of a compressed object such as a compressed gas.
  • the energy for pressurization may be a composite energy obtained by appropriately combining internal energy such as combustion energy, energy by electric power, and elastic energy.
  • the injection liquid transferred to the injection device via the adapter according to the present invention includes a substance containing a component expected to be effective in an injection target region or a component expected to exhibit a predetermined function in the target region.
  • the physical form of the injection liquid may be in a state of being dissolved in the liquid, or may be simply mixed without being dissolved in the liquid.
  • predetermined substances to be delivered include vaccines for antibody enhancement, proteins for beauty, cultured cells for hair regeneration, etc., which must be included in a liquid medium so that they can be ejected.
  • an injection liquid is formed.
  • the medium a medium which does not inhibit the above-mentioned effects and functions of the predetermined substance when injected into the target region is preferable.
  • the medium may be a medium that, when injected into the target area, exerts the above-mentioned effects and functions by acting together with a predetermined substance.
  • the injection liquid is delivered into the target area in this way, it is necessary to pay attention to hygiene when the liquid is transferred from the accommodation section defined in the housing of the adapter to the injection apparatus. In particular, if the transfer takes a long time, the time during which the injection liquid is exposed to the external environment becomes long, which is not hygienic.
  • the adapter can transfer the injection liquid while the filling nozzle is in contact with the end surface of the injection nozzle of the injection device. .
  • the opening end of the filling nozzle is set to be smaller than the inner diameter of the storage portion but larger than the injection port of the injection nozzle.
  • the diameter of the filling nozzle from which the injection liquid flows out is not unnecessarily reduced, and it is possible to prevent the transfer speed of the injection liquid from being greatly reduced and the transfer time from being lengthened.
  • the filling nozzle is in contact with the end face of the injection device, and the adapter can be stably positioned with respect to the injection device, so that a suitable transfer of the injection liquid can be realized.
  • the injection liquid moves from a partial area of the storage section through the internal space of the filling nozzle toward the opening end thereof.
  • the continuous predetermined space including at least a part of the region is formed such that the inner diameter of the predetermined space is reduced as it goes to the opening end side of the filling nozzle.
  • the predetermined space is a space including all of the partial region and the internal space of the filling nozzle, in which case, the predetermined space is an opening of the filling nozzle from the partial region. It may be formed so that the inner diameter of the predetermined space is continuously reduced as it advances toward the opening end of the filling nozzle to the end. According to this configuration, the dispersion of the injection liquid at the filling nozzle can be more effectively suppressed, and even when an extremely small amount of the injection liquid is transferred, the mixture with the air can be effectively suppressed.
  • the filling nozzle is an annular projection projecting outward from the filling nozzle, and when the housing is attached to the injection device, the tip of the projection is the injection tip.
  • the device may have a protrusion formed to contact the end face of the device.
  • the annular protrusion contacts the end face of the injection device so as to surround a portion where the filling nozzle communicates with the injection nozzle.
  • the protrusion may be formed of a flexible member.
  • the protrusion when the adapter is positioned on the injection device, the protrusion is suitably deformed, and a suitable contact state is formed between the adapter and the injection device. Therefore, a suitable sealing property is created between the adapter and the injection device, thereby preventing the injection liquid from leaking when the injection liquid is transferred, and allowing more injection liquid to be transferred to the injection device.
  • the flexible member forming the protrusion does not need to be limited to a specific material, and a suitable flexible material can be selected from the viewpoint of sealing properties useful for transferring the injection liquid.
  • the injection device has a columnar nozzle portion having the injection nozzle therein, and has a nozzle portion formed such that an injection port of the injection nozzle is exposed at an end surface thereof.
  • the housing is provided so as to surround the filling nozzle in the housing, and is fitted to the outer peripheral wall surface of the nozzle portion when the housing is attached to the injection device.
  • You may have a 1st cylindrical part.
  • the outer peripheral wall surface of the nozzle portion forms a tapered surface that is inclined along an axial direction of the nozzle portion.
  • the inner wall surface of the first tubular portion may be in the fitted state while pressing the outer peripheral wall surface of the nozzle portion.
  • the contact support between the inner wall surface of the first cylindrical portion and the outer wall surface of the nozzle portion is strengthened, so that a more stable mounting of the adapter can be expected.
  • a holding portion for holding a state where the first cylindrical portion and the outer peripheral wall surface of the nozzle portion are fitted when the housing is attached to the injection device. Is also good.
  • the holding portion the fitting state between the first cylindrical portion and the outer peripheral wall surface of the nozzle portion is held, so that the injection liquid can be transferred more favorably.
  • the housing is provided so as to surround the first cylindrical portion in the housing, and the housing is provided when the housing is attached to the injection device.
  • the device may have a second cylindrical portion fitted to the outer peripheral wall surface of the device.
  • the invention of the present application can also be understood from the aspect of a method of transferring an injection liquid from an adapter stored in a storage unit to an injection device. That is, the method is an adapter for transferring the predetermined injection liquid through an injection port of the injection nozzle to an injection device that injects the predetermined injection liquid from the injection nozzle.
  • a housing defining a storage portion for storing a predetermined injection liquid; and a housing connected to the storage portion in the housing, the opening end of which is set smaller than the inner diameter of the storage portion and larger than the injection port of the injection nozzle.
  • a continuous predetermined space including at least the partial region in the internal space of the housing from the partial region of the housing portion to which the filling nozzle is connected to the opening end of the filling nozzle.
  • an adapter formed such that the inside diameter of the predetermined space is reduced as it proceeds to the opening end side of the filling nozzle attaching the housing to the injection device, The tip of the filling nozzle is brought into contact with the end face of the injection device in which the injection port of the chir is formed, the predetermined injection liquid is injected into the housing portion, and the adapter is upward in the vertical direction of the injection device. In the position, the predetermined injection liquid is transferred from the storage section and transferred to the injection device.
  • the technical concept disclosed in connection with the adapter can be applied to the invention according to the method as long as no technical inconsistency arises.
  • FIG. 2 is a diagram showing a schematic configuration of a first sub-assembly constituting a device assembly incorporated in the needleless syringe shown in FIG. 1.
  • FIG. 2 is a diagram showing a schematic configuration of a second sub-assembly constituting a device assembly incorporated in the syringe shown in FIG. 1.
  • FIG. 2B is a perspective view of an adapter used to transfer the injection liquid ejected by the needleless injector to the first subassembly shown in FIG. 2A.
  • FIG. 4 is a sectional view of the adapter shown in FIG. 3.
  • FIG. 3 is a perspective view of an adapter used to transfer the injection liquid ejected by the needleless injector to the first subassembly shown in FIG. 3.
  • FIG. 7 is a first view showing a state where an adapter is attached to the first sub-assembly. It is a flowchart which shows the flow of the transfer method of the injection liquid using an adapter.
  • FIG. 8 is a second view showing a state where an adapter is attached to the first sub-assembly.
  • the syringe 1 uses a combustion energy of an explosive to eject an injection liquid corresponding to an injection target substance of the present application into a target area, that is, a needleless syringe, that is, injects an injection liquid into a target area without passing through a syringe needle. It is a device that performs injection. Before describing the details of the adapter 90, the syringe 1 will be described.
  • distal end side and proximal end side are used as terms representing the relative positional relationship in the longitudinal direction of the syringe 1.
  • the “distal side” indicates a position near the distal end of the syringe 1 described later, that is, a position near the injection port 31a, and the “proximal side” is a direction opposite to the “distal side” in the longitudinal direction of the syringe 1, That is, the direction of the driving unit 7 is shown.
  • the downstream side of the flow during the transfer of the injection liquid that is, the lower side shown in FIG. 4 is referred to as “distal side”, and the upper side shown in FIG. Is done.
  • FIG. 1 is a diagram showing a schematic configuration of the syringe 1 and also a cross-sectional view of the syringe 1 along the longitudinal direction.
  • the syringe 1 includes a sub-assembly (see FIG. 2A described later) 10A including a syringe unit 3 and a plunger 4 described later, and a sub-assembly (referred to as a syringe unit 3 and a piston 5 and a driving unit 7). (See FIG. 2B described later.)
  • the device assembly 10 in which the device assembly 10B and the device assembly 10B are integrally assembled is attached to the syringe housing 2.
  • the injection liquid administered to the target region by the syringe 1 is formed by including a predetermined substance exhibiting expected effects and functions in the target region in a liquid medium. ing.
  • the predetermined substance may be dissolved in a liquid as a medium, or may be simply mixed without being dissolved.
  • the predetermined substance contained in the injection liquid examples include a biological substance that can be injected into a target region that is a living body and a substance that emits a desired physiological activity.
  • the biological substance include DNA, RNA, and nucleic acid. , Antibodies, cells, and the like, and as a substance emitting a physiological activity, it has various pharmacological and therapeutic effects including a low molecular drug, an inorganic substance such as metal particles for hyperthermia or radiation therapy, and a carrier serving as a carrier. Substances and the like.
  • the liquid serving as the medium of the injection liquid may be any substance that is suitable for administering these predetermined substances into the target region, and may be aqueous or oily. Further, as long as the predetermined substance can be injected by the syringe 1, the viscosity of the liquid as the medium is not particularly limited.
  • the device assembly 10 is configured to be detachable from the syringe housing 2.
  • a storage part 32 (see FIG. 2A) formed between the syringe part 3 and the plunger 4 included in the device assembly 10 is filled with the injection liquid in a preparation stage before the operation of the syringe 1, and
  • the device assembly 10 is a unit that is replaced each time the injection liquid is injected.
  • a battery 9 for supplying power to an igniter 71 included in the drive unit 7 of the device assembly 10 is included on the syringe housing 2 side.
  • the power supply from the battery 9 is performed by a user performing an operation of pressing a button 8 provided on the syringe housing 2, and the electrodes on the syringe housing 2 side and the driving unit 7 side of the device assembly 10 are connected via wiring. It will be performed between the electrodes.
  • the electrodes on the side of the syringe housing 2 and the electrodes on the side of the drive unit 7 of the device assembly 10 are formed so that the shape and position of both electrodes are automatically contacted when the device assembly 10 is mounted on the syringe housing 2. Designed.
  • the syringe housing 2 is a unit that can be used repeatedly as long as the power that can be supplied to the drive unit 7 remains in the battery 9. Then, in the syringe housing 2, when the power of the battery 9 is lost, only the battery 9 may be replaced and the syringe housing 2 may be used continuously.
  • the syringe part 3 has a nozzle part 31 including a storage part 32 which is a space capable of storing the injection liquid, and the plunger 4 is arranged so as to be slidable in the storage part 32 in the sub-assembly 10A. Is done.
  • the outer periphery on the tip side of the nozzle portion 32 is formed in a columnar shape.
  • the body 30 of the syringe unit 3 for example, known nylon 6-12, polyarylate, polybutylene terephthalate, polyphenylene sulfide, liquid crystal polymer, or the like can be used. These resins may also contain fillers such as glass fibers and glass fillers. For polybutylene terephthalate, 20 to 80% by mass of glass fibers, for polyphenylene sulfide, 20 to 80% by mass of glass fibers, Further, the liquid crystal polymer may contain 20 to 80% by mass of mineral.
  • the plunger 4 is arranged so as to be slidable in the direction of the nozzle 31 (in the direction toward the tip end) in the housing portion 32 formed inside the body 30, and between the plunger 4 and the body of the syringe 3.
  • the formed space is a space in which the injection liquid 320 is sealed.
  • the injection liquid 320 is transferred into the storage section 32 by using the adapter 90 shown in FIG. 3 and the like, and details thereof will be described later.
  • the injection liquid 320 stored in the storage portion 32 is pressed and passes through the injection nozzle 31 b provided on the tip side of the nozzle portion 31. It will be injected from the injection port 31a.
  • the injection port 31a is open at an end face (tip face) 31c on the tip side of the nozzle portion 31.
  • the tip surface 31c is substantially flat except for the injection port 31a.
  • the plunger 4 is made of a material that slides smoothly in the housing portion 32 and does not leak the injection liquid 320 from the plunger 4 side.
  • a specific material of the plunger 4 for example, butyl rubber or silicon rubber can be adopted.
  • styrene-based elastomers, hydrogenated styrene-based elastomers, and polyolefins such as polyethylene, polypropylene, polybutene, ⁇ -olefin copolymers and the like, oils such as process oils, process oils and the like, and powders such as talc, cast and mica What mixed the inorganic substance is mentioned.
  • various rubber materials such as polyvinyl chloride elastomer, olefin elastomer, polyester elastomer, polyamide elastomer, polyurethane elastomer, natural rubber, isoprene rubber, chloroprene rubber, nitrile-butadiene rubber, and styrene-butadiene rubber (particularly, Sulfurized products), mixtures thereof, and the like can also be employed as the material of the plunger 4.
  • the surface of the plunger 4 and the surface of the housing portion 32 of the syringe unit 3 may be coated and processed with various substances in order to secure and adjust the slidability between the plunger 4 and the syringe unit 3.
  • PTFE polytetrafluoroethylene
  • silicon oil diamond-like carbon, nanodiamond and the like
  • the plunger 4 has a head 41 and a body 42, and the two are connected by a neck 43 having a diameter smaller than the diameter of the head 41 and the body 42. You can be.
  • the reason why the diameter of the neck portion 43 is reduced in this way is to form an accommodation space for an O-ring serving as a seal member.
  • the contour on the tip end side of the head 41 has a shape that substantially matches the contour of the inner wall surface of the nozzle portion 31.
  • the shape of the plunger 4 is not limited to a specific shape as long as a desired effect is obtained in the syringe of the present embodiment.
  • the plunger 4 is provided with a rod portion 44 extending from the end face on the base end side of the body section 42 to the direction further on the base end side.
  • the diameter of the rod portion 44 is sufficiently smaller than the diameter of the body portion 42, the rod portion 44 has a diameter that allows a user to grip the rod portion 44 and move the inside of the housing portion 32.
  • the rod portion 44 projects from the proximal end surface of the syringe portion 3 so that the user can grip the rod portion 44.
  • the length of the part 44 is determined.
  • the inner diameter of the injection nozzle 31b provided in the nozzle part 31 on the syringe part 3 side is formed smaller than the inner diameter of the housing part 32.
  • the injection liquid 320 pressurized to a high pressure is injected outside from the injection port 31a of the injection nozzle 31b.
  • a screw portion 33a for connecting the syringe body 6 and the syringe portion 3 on the sub-assembly 10B side described later is formed in the neck portion 33 located on the proximal end side of the syringe portion 3.
  • the diameter of the neck 33 is set smaller than the diameter of the body 30.
  • the piston 5 is configured to be pressurized by a combustion product generated by the igniter 71 of the drive unit 7 and slide in a through hole 64 formed inside the body 60 of the syringe body 6.
  • a coupling recess 61 is formed on the distal end side of the syringe body 6 with reference to the through hole 64.
  • the coupling concave portion 61 is a portion that is coupled to the neck portion 33 of the syringe portion 3, and a screw portion 62 a that is screwed with a screw portion 33 a provided on the neck portion 33 is formed on a side wall surface 62 of the coupling concave portion 61. ing.
  • the through hole 64 and the coupling concave portion 61 are connected by a communication portion 63, and the diameter of the communication portion 63 is set smaller than the diameter of the through hole 64.
  • a recess 65 for a drive unit is formed on the base end side of the syringe body 6 with reference to the through hole 64.
  • the drive unit 7 is arranged in the drive unit recess 65.
  • the piston 5 is made of metal, and has a first body 51 and a second body 52.
  • the piston 5 is arranged in the through hole 64 such that the first body 51 faces the coupling recess 61 and the second body 52 faces the drive unit recess 65.
  • the piston 5 slides in the through hole 64 while the first body 51 and the second body 52 face the inner wall surface of the through hole 64 of the syringe body 6.
  • the first trunk portion 51 and the second trunk portion 52 are connected by a connecting portion smaller than the diameter of each trunk portion, and a space formed between the two trunk portions is formed with a through hole 64.
  • An O-ring or the like is arranged in order to increase the adhesion to the inner wall surface.
  • the piston 5 may be made of a resin, and in that case, a portion requiring heat resistance and pressure resistance may use a metal together.
  • a pressing pillar 53 having a smaller diameter than the first body 51 and a diameter smaller than the diameter of the communication part 63 of the syringe body 6 is provided on an end surface on the distal end side of the first body 51.
  • the pressing column portion 53 is provided with a receiving hole 54 which is open at the end face on the distal end side, the diameter of which is greater than the diameter of the rod portion 44, and whose depth is greater than the length of the rod portion 44. . Therefore, when the piston 5 is pressurized by the combustion product of the igniter 71, the pressing column portion 53 transfers the combustion energy via the end surface on the distal end side to the proximal end surface of the body portion 42 of the plunger 4. It is possible to tell.
  • the shape of the piston 5 is not limited to the shape shown in FIG. 2B.
  • the drive unit 7 has an igniter 71 which is an electric igniter that has a body 72 formed in a cylindrical shape and burns an igniter to generate energy for injection.
  • the combustion energy is arranged in the drive unit concave portion 65 so that the combustion energy is transmitted to the second body portion 52 of the piston 5.
  • the body 72 of the drive unit 7 may be formed by fixing injection-molded resin to a metal collar. For the injection molding, a known method can be used.
  • the resin material of the body 72 of the drive unit 7 is formed of the same resin material as the body 30 of the syringe unit 3.
  • the combustion energy of the igniter used in the igniter 71 is energy for the injector 1 to inject the injection liquid into the target area.
  • the igniting charge is preferably an explosive containing zirconium and potassium perchlorate (ZPP), an explosive containing titanium hydride and potassium perchlorate (THPP), or an explosive containing titanium and potassium perchlorate (TiPP).
  • AFO gunpowder containing iron oxide (AFO), or an explosive consisting of a combination of a plurality of these explosives is exemplified. These explosives generate high-temperature and high-pressure plasma during combustion immediately after ignition, but exhibit a characteristic that when they reach room temperature and combustion products condense, they do not contain gaseous components and the generated pressure drops rapidly. Other explosives may be used as the igniting charge as long as an appropriate injection liquid can be injected.
  • a gas generated by combustion by the combustion product generated by the explosive combustion in the igniter 71 generates gas.
  • a generator 80 is provided.
  • the location is, for example, a location that can be exposed to combustion products from the igniter 71 as shown in FIGS. 1 and 2B.
  • the gas generating agent 80 may be disposed in the igniter 71 as disclosed in International Publication WO 01-031282, JP 2003-25950 A, and the like.
  • gas generating agent is a single-base smokeless explosive comprising 98% by mass of nitrocellulose, 0.8% by mass of diphenylamine, and 1.2% by mass of potassium sulfate. It is also possible to use various gas generating agents used in gas generators for airbags and gas generators for seatbelt pretensioners. By adjusting the size, size, and shape, particularly the surface shape of the gas generating agent when arranged in the through hole 64, it is possible to change the combustion completion time of the gas generating agent, By adjusting the transition of the pressure applied to the injection liquid, the injection pressure can be set to a desired transition.
  • the transfer of the injection liquid 320 to the sub-assembly 10A is performed using the adapter 90 shown in FIG.
  • the proximal end surface of the body portion 42 of the plunger 4 is connected to the proximal end surface of the syringe portion 3.
  • the plunger 4 is pulled out to a position slightly protruding from the end face.
  • the piston 5 is inserted from the proximal end side of the syringe main body 6 shown in FIG. 2B.
  • the piston 5 is inserted into the through-hole 64 such that the pressing pillar 53 faces the coupling recess 61.
  • the end face on the tip end side of the piston 5, that is, the end face on the tip end side of the pressing column portion 53 in which the housing hole 54 is opened, is in a state of protruding a predetermined amount from the bottom surface (the surface orthogonal to the side wall surface 62) of the coupling recess 61. Is positioned as follows.
  • the positioning of the piston 5 a known technique such as setting a mark for positioning in the through hole 64 or using a positioning jig may be appropriately used. Then, the gas generating agent 80 is arranged in the through hole 64 and the driving unit 7 is attached to the driving unit concave portion 65.
  • the fixing force of the piston 5 in the through-hole 64 is such that the piston 5 can slide in the through-hole 64 sufficiently and smoothly depending on the pressure received from the combustion product by the igniter 71 of the drive unit 7.
  • the piston 5 sufficiently resists the force received from the plunger 4, and the position of the piston 5 does not fluctuate.
  • the apparatus assembly 10 is formed by attaching the sub-assembly 10A thus configured to the sub-assembly 10B by screwing the screw portions 33a and 62a. At this time, as the coupling between the two progresses, the rod portion 44 of the plunger 4 enters and is housed in the housing hole 54 provided in the pressing column portion 53 of the piston 5, and finally, is housed. Thus, the end surface on the distal end side of the pressing pillar 53 comes into contact with the end surface on the proximal end side of the body 42 of the plunger 4.
  • the accommodation hole 54 is large enough to accommodate the rod portion 44, in this contact state, the inner wall surface at the back of the accommodation hole 54 (particularly, the bottom surface of the accommodation hole 54) is No contact is made with the proximal end of the rod 44, so that the rod portion 44 does not receive a load from the piston 5 side.
  • the position of the piston 5 is fixed to the through hole 64 with a sufficient frictional force as described above, so that the plunger 4 is moved toward the injection port 31a by the pressing column 53.
  • the plunger 4 is positioned in the syringe section 3 by being pushed forward.
  • a part of the injection liquid 320 corresponding to the amount of pushing of the plunger 4 is discharged from the injection port 31a.
  • the formation of the device assembly 10 is completed.
  • the piston 5 is positioned at a predetermined position with respect to the syringe main body 6, and the position of the plunger 4 in the housing portion 32 of the syringe unit 3 is mechanically determined based on the piston 5. It is finally decided. Since the final position of the plunger 4 is a position uniquely determined in the apparatus assembly 10, the amount of the injection liquid 320 finally stored in the storage portion 32 is reduced to a predetermined amount. It becomes possible.
  • the device assembly 10 is attached to the syringe housing 2, and when the user presses the button 8 in a state where the injection port 31 a is in contact with the target area, the injection liquid is injected through the piston 5 and the plunger 4. 320 is pressurized, its injection is performed, and injection liquid 320 is injected into the target area.
  • FIG. 3 is a perspective view of the adapter 90
  • FIG. 4 is a sectional view of the adapter 90
  • FIG. 5 is a diagram illustrating a usage state of the adapter 90.
  • Adapter 90 has a housing 99 forming its body.
  • the housing 99 is formed of a predetermined resin material that is injection-molded.
  • the resin material of the adapter 90 is the same as the resin material of the body 30 of the syringe unit 3.
  • known nylon 6-12, polyarylate, polybutylene terephthalate, polyphenylene sulfide, liquid crystal polymer, or the like can be used.
  • a predetermined parameter for example, Vickers
  • Vickers related to the hardness of the resin material is compared with the body 30 of the syringe unit 3 so that the protrusion 92b included in the adapter 90 is provided with suitable flexibility.
  • the material of the protrusion 92b may be different from the material of the housing 99.
  • polypropylene may be used as the material of the housing 99
  • silicon rubber may be used as the material of the protrusion 92b.
  • the housing 99 has an upper peripheral wall portion 91 located above in the state shown in FIG. 4, a flange 94 connected to the upper peripheral wall portion 91, and a flange 94 positioned below the flange 94. It has a lower peripheral wall 95 connected thereto.
  • the upper peripheral wall portion 91, the flange portion 94, and the lower peripheral wall portion 95 are portions that can be visually recognized from the outside of the adapter 90 as shown in FIG.
  • the upper peripheral wall portion 91 has a substantially cylindrical shape connected to the flange portion 94 in a state where the upper peripheral wall portion 91 is tapered so as to approach the central axis L1 of the adapter 90 as it goes upward from the flange portion 94. .
  • a predetermined space 99 a is defined inside the housing 99 by the upper peripheral wall portion 91.
  • the predetermined space 99a functions as a storage section 99a for storing the injection liquid.
  • the accommodation portion 99a is connected to the filling nozzle 92 below the accommodation portion 99a, as described later.
  • the accommodating portion 99a is formed so as to become smaller as going to.
  • a filling nozzle 92 is provided below the housing portion 99a and communicates with the housing portion 99a.
  • the filling nozzle 92 has a projection formed by partly protruding toward the distal end side of the adapter 90 so that a part of the inner wall surface of the upper peripheral wall portion 91 narrows its internal space. Therefore, the uppermost end (base end) of the filling nozzle 92 communicates with the housing portion 99a, and the inner diameter of the filling nozzle 92 at the uppermost end matches the innermost diameter of the lowermost end of the housing portion 99a to be connected.
  • an opening end 92a is formed at the lowermost end (tip) of the filling nozzle 92, that is, at the tip of the projection, and the inside diameter of the opening end 92a is the inside diameter of the accommodation portion 99a, particularly, the inside diameter of the accommodation portion 99a. Is smaller than the inner diameter at the lowermost end.
  • the filling nozzle 92 is formed such that the inner diameter decreases from the uppermost end to the open end 92a, which is the lowermost end.
  • a cylindrical tubular portion 93 extending downward from the middle.
  • the inner wall surface 93a of the tubular portion 93 is substantially parallel to the center axis L1 of the adapter 90.
  • the tubular portion 93 corresponds to a first tubular portion.
  • the inner diameter of the internal space defined by the inner wall surface 93a is equal to the outer diameter of the columnar nozzle portion 31 located at the tip (the leftmost portion in the state shown in FIG. 2A) of the body 30 of the syringe portion 3. Corresponding, and preferably substantially coincident.
  • a portion from the position where the tubular portion 93 is provided to the tip of the filling nozzle 92 is referred to as a protrusion 92b.
  • the protruding portion 92b is annularly protruding into the internal space of the cylindrical portion 93, and the opening end 92a of the filling nozzle 92 is defined by the edge of the protruding portion 92b on the tip side.
  • the length of the protrusion 92b (or the height in the direction along the central axis L1) is such that the opening end 92a is sufficiently accommodated in the internal space of the cylindrical portion 93, in other words, the tip of the protrusion 92b. This is a degree that ensures a state in which the cylindrical portion 93 extends sufficiently downward from the portion.
  • the flange portion 94 is a flat member connected at the lowermost end of the upper peripheral wall portion 91 and orthogonal to the central axis L1 as shown in FIG.
  • the lower peripheral wall portion 95 is a cylindrical member provided so as to be orthogonal to the flange portion 94, and an inner wall surface 95 a thereof is substantially parallel to the center axis L 1 of the adapter 90.
  • the lower peripheral wall portion 95 corresponds to a second cylindrical portion.
  • the inner diameter of the inner space defined by the inner wall surface 95a is the middle portion of the body 30 of the syringe portion 3 (in the state shown in FIG. 2A, the tip portion where the nozzle portion 31 is located and the base end where the screw portion 33a is provided).
  • Portion which corresponds to the outer diameter of the thickest part of the body 30), and preferably substantially coincides with the outer diameter. Therefore, the inner diameter of the inner space formed by the inner wall surface 95a is larger than the inner diameter of the inner space formed by the inner wall surface 93a. Further, the internal space defined by the inner wall surface 95 a communicates with the internal space defined by the upper peripheral wall portion 91 in the housing 99. However, the cylindrical portion 93 does not reach the internal space defined by the inner wall surface 95a.
  • the adapter 90 configured as described above is attached to the sub-assembly 10A such that the adapter 90 is located above the sub-assembly 10A when transferring the injection liquid, as shown in FIG.
  • This mounting state will be described with reference to FIG.
  • the sub-assembly 10A is preferably arranged such that the injection port 31a faces upward (vertically). Note that the injection port 31a does not necessarily need to face upward, but since the operation of the rod portion 44 is performed in a state where the injection liquid is stored in the storage portion 99a during the transfer of the injection liquid, as described later, the injection liquid is spilled. It is preferable that the injection port 31a faces upward as much as possible in order to prevent the occurrence.
  • the head 41 of the plunger 4 comes into contact with the end face located at the innermost part of the housing part 32 in consideration of the subsequent operation of the rod part 44. State.
  • the distal end of the body 30 is inserted into the internal space of the lower peripheral wall 95 of the adapter 90 in such a subassembly 10A, and the inner wall surface 95a of the lower peripheral wall 95 is , And the inner wall surface 93a of the cylindrical portion 93 is fitted with the columnar tip of the body 30. Then, while maintaining these fitted states, the sub-assembly 10A is inserted into the adapter 90 until the distal end of the protrusion 92b abuts against the distal end surface 31c of the nozzle 31. Note that the mounting state shown in FIG. 5 shows a state in which the distal end of the projection 92b abuts on the distal end surface 31c of the nozzle 31.
  • the housing 99 including the protrusion 92b is formed of a resin material capable of exhibiting suitable flexibility as described above, the protrusion 92b is moved to the distal end surface by a user operation when the adapter 90 is attached.
  • the projection 92b is abutted against the projection 31c, the projection 92b is appropriately bent, and a good contact state is formed between the projection 92b and the distal end surface 31c.
  • a good sealing property is created between the protrusion 92b and the distal end surface 31c, and when the injection liquid is injected into the housing portion 99a, it is possible to suppress the injection liquid from leaking wastefully.
  • the protrusion 92b is in a state of being in annular contact with the distal end face 31c, and the adapter is attached to the sub-assembly 10A by the cylindrical portion 93 and the lower peripheral wall 95. 90 is stably supported. Therefore, safe transfer of the injection liquid can be realized.
  • the above-described adapter 90 is prepared (the process of S101).
  • the head 41 of the plunger 4 is in a state of being in contact with the end face located at the innermost part of the housing portion 32.
  • the adapter 90 is attached to the sub-assembly 10A constituting the syringe 1 to form the attached state shown in FIG. 5 (processing of S102).
  • the injection liquid to be transferred from the open end of the storage unit 99a is injected into the storage unit 99a in a state where the storage unit 99a is positioned above (the state illustrated in FIG. 5).
  • the rod part 44 is pulled down by the user while maintaining the state in which the storage part 99a is positioned so that the injection liquid does not spill.
  • the injection liquid in the storage portion 99a flows into the injection nozzle 31b via the injection port 31a, and reaches the storage portion 32 to be transferred.
  • the adapter 90 attention is paid to the partial region R1 of the storage portion 99a and the entire space inside the filling nozzle 92.
  • These spaces (regions) are continuous spaces from the partial region R1 to the opening end 92a inside the adapter 90, and the spaces correspond to predetermined spaces.
  • the continuous space is configured such that its inner diameter decreases as it goes from the upper side of the adapter 90 to the open end 92a.
  • the integrated structure of the injection liquid by the continuous inclined surface (for example, a funnel-like structure) is formed, so that the injection liquid can be efficiently transferred, and at the same time, the air existing around the transfer can be removed. Transfer can be performed while suppressing the degree of mixing with the injection liquid.
  • the continuous inclined surface is formed in the entire space inside the filling nozzle 92.
  • the internal space of the filling nozzle 92 is A space defined by an inner wall surface other than the continuous inclined surface (for example, an inner wall surface parallel to the central axis L1) may be partially included.
  • the opening end 92a is larger than the injection port 31a, the injection liquid easily flows relatively smoothly in the filling nozzle 92 when the rod portion 44 is pulled down. Further, since the annular projection 92b is in contact with the distal end surface 31c with high sealing properties, suction force accompanying the movement of the rod 44 can be effectively generated. Can be suitably performed.
  • the adapter 90 is detached from the sub-assembly 10A, and the injection liquid is filled in the accommodation part 32 as shown in FIG. 2A. Thereafter, the sub-assembly 10A is combined with the sub-assembly 10B and mounted on the syringe housing 2, so that the syringe 1 in a usable state can be prepared.
  • the inner wall surface 93a of the cylindrical portion 93 is fitted with the outer peripheral surface of the columnar nozzle portion 31 to change the attachment state of the adapter to the sub-assembly 10A. It is stable.
  • the outer peripheral surface of the nozzle portion 31 is further tapered inclining along its axial direction (for example, in the state shown in FIG. 2A, the nozzle portion 31 moves to the right side (the base end side of the syringe portion 3) in the drawing). 31 may be a tapered surface formed so as to have a large outer diameter.
  • the sub-assembly 10A can be easily inserted into the adapter 90, and the inner wall surface 93a and the tapered surface are fitted while being pressed against each other, so that the coupling force in the mounted state is reduced. It can be increased and a more stable mounting state can be formed.
  • a holding device 96 for holding the mounted state of the adapter 90 and the sub-assembly 10A is provided.
  • the holding device 96 is composed of a first member 96a provided on the adapter 90 side and a second member 96b provided on the sub-assembly 10A side.
  • the holding state between the sub-assembly 90 and the sub-assembly 10A is maintained.
  • a snap fit mechanism that can be engaged and released can be used.

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Abstract

Provided is an adapter for transporting a prescribed injection fluid via an injection aperture of an injection nozzle to an injection device which injects the prescribed injection fluid from the injection nozzle, said adapter comprising: a housing which demarcates a housing part which houses the injection fluid; and a filling nozzle which is disposed in communication with the housing part in the housing and makes contact with an end face of the injection device in which the injection aperture of the injection nozzle is formed when the housing is attached to the injection device, said filling nozzle having an open end configured smaller than the inner diameter of the housing part and larger than the injection aperture of the injection nozzle. A contiguous prescribed space which includes at least a partial region of the housing part from among the internal space of the housing which extends from said partial region to the open end of the filling nozzle is formed such that the inner diameter of the prescribed space is reduced in the direction of the open end side of the filling nozzle. Said configuration makes it possible to appropriately transport an injection fluid to a needle-free syringe from outside of said syringe.

Description

アダプタ、及び射出液の移送方法Adapter and injection liquid transfer method
　本発明は、外部から射出液を注射器側に移送するためのアダプタ、及び当該アダプタを用いた射出液の移送方法に関する。 The present invention relates to an adapter for transferring an injection liquid from the outside to a syringe, and a method for transferring the injection liquid using the adapter.
　生体等の対象領域に薬液等を射出する装置として無針注射器が例示できるが、近年、取り扱いの容易さや衛生面等から、注射針を有しない無針注射器の開発が行われている。一般に、無針注射器では、圧縮ガスやバネ等の駆動源により加圧された薬液を対象領域に向かって射出し、その薬液が有する運動エネルギーを利用して対象領域の内部に薬液が射出される構成が実用化されている。このような無針注射器には射出液の流路を形成する機械的な構成（例えば、注射針）が存在しないため、装置使用の準備段階において、射出液を衛生的に無針注射器に移送するには相応の注意を要する。 針 A needle-free injector can be exemplified as a device for injecting a drug solution or the like into a target area such as a living body. However, in recent years, a needle-free injector without an injection needle has been developed due to ease of handling and hygiene. In general, in a needle-free injector, a drug solution pressurized by a drive source such as a compressed gas or a spring is ejected toward a target region, and the drug solution is ejected into the target region using kinetic energy of the drug solution. The configuration has been put to practical use. Since such a needle-free injector does not have a mechanical configuration (for example, an injection needle) for forming a flow path of the injection liquid, the injection liquid is sanitarily transferred to the needle-free injector in a preparation stage for using the apparatus. Requires some care.
　ここで、特許文献１には、カップリング装置を用いて無針注射器とベッセルを接続して射出液を移送する構成が開示されている。このカップリング装置の一方側に無針注射器が取り付けられ、他方側にベッセルが取り付けられる。ベッセルには、無針注射器によって射出される射出液が貯蔵されている。そして、カップリング装置の当接面は、無針注射器の先端面に倣う形状をしており、且つカップリング装置のオリフィスは、無針注射器側のオリフィスと向かい合った状態となっている。その上で、カップリング装置の当接面は、雑菌等の発生を抑制するために、ベッセルから無針注射器への射出液の移送時に、射出液が無針注射器の先端面に付着しないように形成されている。 Here, Patent Document 1 discloses a configuration in which a needleless syringe and a vessel are connected using a coupling device to transfer an injection liquid. A needleless syringe is attached to one side of the coupling device, and a vessel is attached to the other side. The injection liquid stored by the needleless syringe is stored in the vessel. The contact surface of the coupling device has a shape following the distal end surface of the needle-free injector, and the orifice of the coupling device faces the orifice of the needle-free injector. In addition, the contact surface of the coupling device should prevent the injection liquid from adhering to the distal end surface of the needleless syringe when transferring the injection liquid from the vessel to the needleless syringe in order to suppress the occurrence of various bacteria and the like. Is formed.
米国特許出願公開第２００２／０１６１３３４号明細書U.S. Patent Application Publication No. 2002/0161334
　従来の技術では、射出液の移送中に無針注射器の先端面が射出液に接触しないように(雑菌等が無針注射器の先端面で繁殖するのを防ぐべく)、カップリング装置の先端部のオリフィスの径が、無針注射器のノズル部のオリフィスの径よりも小さく形成されている。一般的に無針注射器は、射出液に高い圧力を作用させて、そのエネルギーで射出液を対象領域に向かって射出させるものであるから、当該射出のためにそのオリフィス径は極めて小さい。したがって、従来技術では、カップリング装置側のオリフィス径は、そのような無針注射器側のオリフィス径よりも小さくなるため、当該カップリング装置を用いて射出液を移送しようとすると、その移送に比較的長い時間を要することになる。また、極めて少量の射出液を移送する場合には、射出液がカップリング装置のオリフィスの先端まで移動しにくい構成となっているため、その周囲に存在する空気も一緒に取り込んで無針注射器に移送されることになる。 In the prior art, the distal end of the coupling device is moved so that the distal end surface of the needle-free injector does not come into contact with the injection liquid during the transfer of the injection liquid (to prevent bacteria from growing on the distal end surface of the needle-free injector). The diameter of the orifice is smaller than the diameter of the orifice in the nozzle portion of the needleless syringe. In general, a needle-free injector applies a high pressure to an ejection liquid to eject the ejection liquid toward a target area with its energy. Therefore, the diameter of the orifice is extremely small due to the injection. Therefore, in the prior art, since the orifice diameter on the coupling device side is smaller than the orifice diameter on the needleless syringe side, it is difficult to transfer the injection liquid using the coupling device. It will take a long time. Also, when transferring a very small amount of injection liquid, the injection liquid is difficult to move to the tip of the orifice of the coupling device, so the air around it is also taken in and injected into the needleless syringe. Will be transported.
　そこで、本発明は、上記した問題に鑑み、外部から無針注射器へ射出液を好適に移送することを可能とする技術を提供することを目的とする。 Accordingly, an object of the present invention is to provide a technique capable of suitably transferring an injection liquid from the outside to a needle-free injector in view of the above-described problems.
　上記課題を解決するために、本発明は、アダプタの開口端が収容部の内径より小さく、射出装置の射出ノズルの射出口より大きく構成されるとともに、移送の際に射出液が分散してしまう空間が存在しないように、アダプタ内部に連続して縮径された所定空間を配置する構成を採用した。このような構成により、アダプタを介して外部から射出装置に射出液を、衛生的に且つ速やかに移送でき、また、その移送の際に射出液と空気が不用意に混在してしまうことを抑制できる。 In order to solve the above-mentioned problem, the present invention is configured such that the opening end of the adapter is smaller than the inner diameter of the housing portion and larger than the injection port of the injection nozzle of the injection device, and the injection liquid is dispersed at the time of transfer. A configuration in which a predetermined space whose diameter is reduced continuously inside the adapter is adopted so that no space exists. With this configuration, the injection liquid can be sanitarily and quickly transferred from the outside to the injection device via the adapter, and the injection liquid and air are prevented from being inadvertently mixed during the transfer. it can.
　具体的には、本発明は、所定の射出液を射出ノズルから射出する射出装置に対して、該射出ノズルの射出口を介して該所定の射出液を移送するためのアダプタであって、移送される前記所定の射出液を収容する収容部を画定するハウジングであって、前記射出装置に対して着脱可能に構成されたハウジングと、前記ハウジングにおいて前記収容部に連通して設けられ、前記ハウジングが前記射出装置に取り付けられたときに前記射出ノズルの前記射出口が形成された該射出装置の端面に接触して該収容部に収容されている前記所定の射出液が該射出ノズル側に流出可能に形成された充填ノズルであって、該充填ノズルの開口端は、該収容部の内径より小さく該射出ノズルの射出口より大きく設定された充填ノズルと、を備える。そして、前記収容部の一部領域から該充填ノズルの開口端に至るまでの前記ハウジングの内部空間のうち少なくとも該一部領域を含む連続した所定空間は、該充填ノズルの開口端側に進むに従い該所定空間の内径が縮径するように形成される。 Specifically, the present invention relates to an adapter for transferring the predetermined injection liquid through an injection port of the injection nozzle to an injection device that outputs the predetermined injection liquid from the injection nozzle, A housing that defines a storage section for storing the predetermined injection liquid, the housing being configured to be detachable from the injection device, and the housing being provided in communication with the storage section in the housing; When the liquid is attached to the injection device, the predetermined injection liquid stored in the storage portion comes into contact with the end surface of the injection device in which the injection port of the injection nozzle is formed and flows out toward the injection nozzle. A filling nozzle formed so as to be capable of being formed, wherein an opening end of the filling nozzle is set to be smaller than an inner diameter of the housing portion and larger than an injection port of the injection nozzle. Then, a continuous predetermined space including at least the partial region in the internal space of the housing from the partial region of the housing portion to the opening end of the filling nozzle is gradually increased toward the opening end side of the filling nozzle. The predetermined space is formed such that the inner diameter of the space is reduced.
　上記射出装置は、射出液を射出ノズルから外部に射出するものであるが、その射出に当たっては準備段階として、外部から射出液をその射出ノズルの射出口を介して移送してくる必要があり、本発明のアダプタは、そのような射出液の射出装置への移送の際に使用される。このとき、アダプタは、射出装置そのものに取り付けられてもよく、別法として射出装置を構成する部品に取り付けられてもよい。本発明においては、当該部品へ取り付けられる構成のアダプタも、当該部品が射出装置の一部を構成する限り、当該射出装置へ取り付けられるアダプタと解される。なお、本願においては、射出装置は、その射出液の射出に関して特定の形態のものには限定されない。例えば、アダプタを介して移送された射出液に対して、射出のための加圧を行うエネルギーとしては、化学的に生成されるエネルギー、例えば、火薬・爆薬等の酸化反応によって生じる燃焼エネルギーであってもよい。また別法として、当該加圧のためのエネルギーは、電気的に生成されてもよく、その一例としては、投入された電力により駆動される圧電素子や電磁アクチュエータに起因するエネルギーであってもよい。更に別法としては、当該加圧のためのエネルギーは、物理的に生成されてもよく、その一例としては、弾性体による弾性エネルギーや圧縮ガス等の圧縮物体が有する内部エネルギーであってもよい。また、当該加圧のためのエネルギーは、これらの燃焼エネルギー、電力によるエネルギー、弾性エネルギー等の内部エネルギーを適宜組み合わせた複合型のエネルギーであっても構わない。 The above-described injection device is for injecting the injection liquid from the injection nozzle to the outside, but it is necessary to transfer the injection liquid from the outside through the injection port of the injection nozzle as a preparation stage in the injection, The adapter of the present invention is used for transferring such an injection liquid to an injection device. At this time, the adapter may be attached to the injection device itself, or alternatively, may be attached to a component constituting the injection device. In the present invention, an adapter configured to be attached to the component is understood to be an adapter attached to the injection device as long as the component forms a part of the injection device. Note that, in the present application, the injection device is not limited to a specific mode regarding the injection of the injection liquid. For example, the energy for pressurizing the injection liquid transferred via the adapter for injection is energy generated chemically, for example, combustion energy generated by an oxidation reaction of explosives, explosives, and the like. You may. Alternatively, the energy for pressurization may be generated electrically, and may be, for example, energy due to a piezoelectric element or an electromagnetic actuator driven by input power. . As still another method, the energy for pressurization may be physically generated, and may be, for example, elastic energy by an elastic body or internal energy of a compressed object such as a compressed gas. . Further, the energy for pressurization may be a composite energy obtained by appropriately combining internal energy such as combustion energy, energy by electric power, and elastic energy.
　また、本発明にアダプタを介して射出装置に移送される射出液としては、射出の対象領域内で効能が期待される成分や対象領域内で所定の機能の発揮が期待される成分を含む物質が例示できる。そのため、少なくとも射出が可能であれば、射出液の物理的形態は、液体内に溶解した状態で存在してもよく、又は液体に溶解せずに単に混合された状態であってもよい。一例を挙げれば、送りこむべき所定物質として、抗体増強のためのワクチン、美容のためのタンパク質、毛髪再生用の培養細胞等があり、これらが射出可能となるように、液体の媒体に含まれることで射出液が形成される。なお、上記媒体としては、対象領域内部に注射された状態において所定物質の上記効能や機能を阻害するものでない媒体が好ましい。別法として、上記媒体は、対象領域内部に注射された状態において、所定物質とともに作用することで上記効能や機能が発揮される媒体であってもよい。 In addition, the injection liquid transferred to the injection device via the adapter according to the present invention includes a substance containing a component expected to be effective in an injection target region or a component expected to exhibit a predetermined function in the target region. Can be exemplified. Therefore, at least as long as injection is possible, the physical form of the injection liquid may be in a state of being dissolved in the liquid, or may be simply mixed without being dissolved in the liquid. For example, predetermined substances to be delivered include vaccines for antibody enhancement, proteins for beauty, cultured cells for hair regeneration, etc., which must be included in a liquid medium so that they can be ejected. Thus, an injection liquid is formed. In addition, as the above-mentioned medium, a medium which does not inhibit the above-mentioned effects and functions of the predetermined substance when injected into the target region is preferable. Alternatively, the medium may be a medium that, when injected into the target area, exerts the above-mentioned effects and functions by acting together with a predetermined substance.
　このように射出液は対象領域内に送達されるものであることから、アダプタのハウジングに画定された収容部から射出装置に移送されるに際して衛生面で留意する必要がある。特に、移送に長い時間を要してしまうと、射出液が外部環境に晒されてしまう時間が長くなってしまい、衛生的に好ましくない。上記アダプタは、そのハウジングが射出液の移送のために射出装置に取り付けられたときに、充填ノズルが射出装置の射出ノズルの端面に接触した状態で射出液の移送が可能な状態が形成される。そして、充填ノズルの開口端は、収容部の内径より小さいが射出ノズルの射出口より大きく設定されている。そのため、射出液が流れ出る充填ノズル径がいたずらに小さくならず、射出液の移送速度が大きく低下し移送時間が長期化することを回避できる。また、その移送の際には、充填ノズルが射出装置の端面に接しており、アダプタを射出装置に安定して位置決めでき、以て好適な射出液の移送が実現できる。 射出 Since the injection liquid is delivered into the target area in this way, it is necessary to pay attention to hygiene when the liquid is transferred from the accommodation section defined in the housing of the adapter to the injection apparatus. In particular, if the transfer takes a long time, the time during which the injection liquid is exposed to the external environment becomes long, which is not hygienic. When the housing is attached to the injection device for transporting the injection liquid, the adapter can transfer the injection liquid while the filling nozzle is in contact with the end surface of the injection nozzle of the injection device. . The opening end of the filling nozzle is set to be smaller than the inner diameter of the storage portion but larger than the injection port of the injection nozzle. For this reason, the diameter of the filling nozzle from which the injection liquid flows out is not unnecessarily reduced, and it is possible to prevent the transfer speed of the injection liquid from being greatly reduced and the transfer time from being lengthened. In addition, during the transfer, the filling nozzle is in contact with the end face of the injection device, and the adapter can be stably positioned with respect to the injection device, so that a suitable transfer of the injection liquid can be realized.
　また、射出液が収容部から射出装置に移送されていく過程において、収容部の一部領域から充填ノズルの内部空間を通りその開口端に向かって移動することになる。ここで、上記アダプタでは、少なくともその一部領域を含む連続した所定空間は、充填ノズルの開口端側に進むに従ってその所定空間の内径が縮径するように形成されている。このような構成により、移送に際して射出液が充填ノズル内で分散されずに集約されやすくなり、以て移送の際に周囲の空気を巻き込んで射出装置に移送されることを抑制することができる。このように本願のアダプタによれば、外部から無針注射器へ射出液を好適に移送することが可能となる。そして、より好ましくは、前記所定空間が、前記一部領域と前記充填ノズルの内部空間の全てを含む空間であって、その場合は、前記所定空間が、前記一部領域から前記充填ノズルの開口端まで該充填ノズルの開口端側に進むに従い、該所定空間の内径が連続して縮径するように形成されてもよい。この構成によれば、射出液の充填ノズルでの分散をより効果的に抑制でき、極めて少量の射出液を移送する場合であっても空気との混在を効果的に抑制することができる。 In addition, in the process of transferring the injection liquid from the storage section to the injection device, the injection liquid moves from a partial area of the storage section through the internal space of the filling nozzle toward the opening end thereof. Here, in the adapter, the continuous predetermined space including at least a part of the region is formed such that the inner diameter of the predetermined space is reduced as it goes to the opening end side of the filling nozzle. With such a configuration, the injection liquid is easily dispersed and dispersed in the filling nozzle at the time of transfer, so that it is possible to prevent the surrounding air from being entrained and transferred to the injection device during transfer. As described above, according to the adapter of the present application, it is possible to preferably transfer the injection liquid from the outside to the needleless syringe. And more preferably, the predetermined space is a space including all of the partial region and the internal space of the filling nozzle, in which case, the predetermined space is an opening of the filling nozzle from the partial region. It may be formed so that the inner diameter of the predetermined space is continuously reduced as it advances toward the opening end of the filling nozzle to the end. According to this configuration, the dispersion of the injection liquid at the filling nozzle can be more effectively suppressed, and even when an extremely small amount of the injection liquid is transferred, the mixture with the air can be effectively suppressed.
　また、上述までのアダプタにおいて、前記充填ノズルは、該充填ノズルからその外側に突出した環状の突起部であって、該ハウジングが前記射出装置に取り付けられたときに該突起部の先端が該射出装置の端面に当接するように形成された突起部を有してもよい。上記アダプタがこのような突起部を有することで、充填ノズルと射出ノズルが連通する部位を囲むように環状の当該突起部が射出装置の端面に接触することになる。その結果、射出液の移送の際に、より安定的にアダプタを射出装置に位置決めできるとともに、射出液が漏れ出すのを抑制し射出装置への移送がより良好に達成されることになる。 Further, in the adapter described above, the filling nozzle is an annular projection projecting outward from the filling nozzle, and when the housing is attached to the injection device, the tip of the projection is the injection tip. The device may have a protrusion formed to contact the end face of the device. When the adapter has such a protrusion, the annular protrusion contacts the end face of the injection device so as to surround a portion where the filling nozzle communicates with the injection nozzle. As a result, during the transfer of the injection liquid, the adapter can be more stably positioned in the injection apparatus, and the leakage of the injection liquid is suppressed, and the transfer to the injection apparatus is more preferably achieved.
　また、上記突起部は、可撓性部材から形成されてもよい。このような構成により、アダプタを射出装置に位置決めした際に突起部が好適に変形し、アダプタと射出装置との間に好適な接触状態を形成する。そのため、アダプタと射出装置との間に好適なシール性が生まれ、以て射出液の移送の際に射出液が漏れ出すのを抑制し、より多くの射出液を射出装置へ移送させることが可能となる。なお、突起部を形成する可撓性部材は、特定の材料に限定される必要は無く、射出液の移送に有用なシール性の観点から好適な可撓性材料を選択することができる。 The protrusion may be formed of a flexible member. With such a configuration, when the adapter is positioned on the injection device, the protrusion is suitably deformed, and a suitable contact state is formed between the adapter and the injection device. Therefore, a suitable sealing property is created between the adapter and the injection device, thereby preventing the injection liquid from leaking when the injection liquid is transferred, and allowing more injection liquid to be transferred to the injection device. Becomes In addition, the flexible member forming the protrusion does not need to be limited to a specific material, and a suitable flexible material can be selected from the viewpoint of sealing properties useful for transferring the injection liquid.
　ここで、上述までのアダプタにおいて、前記射出装置は、前記射出ノズルを内部に有する柱状のノズル部であって、該射出ノズルの射出口がその端面に露出して形成されたノズル部を有してもよい。その上で、前記ハウジングは、該ハウジングにおいて前記充填ノズルを囲むように設けられ、且つ、該ハウジングが前記射出装置に取り付けられたときに前記ノズル部の外周壁面に対して嵌合した状態となる第１筒状部を有してもよい。このような構成を採用することで、ハウジングを介してアダプタが射出装置に取り付けられたときに、第１筒状部がノズル部の外周壁面と接触支持する位置関係となり、以て、その取付状態の安定性を高めることができる。 Here, in the adapter described above, the injection device has a columnar nozzle portion having the injection nozzle therein, and has a nozzle portion formed such that an injection port of the injection nozzle is exposed at an end surface thereof. You may. Then, the housing is provided so as to surround the filling nozzle in the housing, and is fitted to the outer peripheral wall surface of the nozzle portion when the housing is attached to the injection device. You may have a 1st cylindrical part. By adopting such a configuration, when the adapter is attached to the injection device via the housing, the first cylindrical portion comes into contact with and supports the outer peripheral wall surface of the nozzle portion. Stability can be improved.
　また、上記構成のアダプタにおいて、前記ノズル部の前記外周壁面は、該ノズル部の軸方向に沿って傾斜するテーパ面を形成し、その場合、前記ハウジングが前記装置本体に取り付けられたときに、前記第１筒状部の内壁面は前記ノズル部の前記外周壁面を押圧しながら前記嵌合した状態となってもよい。この結果、第１筒状部の内壁面とノズル部の外周壁面との接触支持が強まるため、更に安定したアダプタの取り付けが期待できる。 Further, in the adapter having the above configuration, the outer peripheral wall surface of the nozzle portion forms a tapered surface that is inclined along an axial direction of the nozzle portion. In this case, when the housing is attached to the device main body, The inner wall surface of the first tubular portion may be in the fitted state while pressing the outer peripheral wall surface of the nozzle portion. As a result, the contact support between the inner wall surface of the first cylindrical portion and the outer wall surface of the nozzle portion is strengthened, so that a more stable mounting of the adapter can be expected.
　また、上述までのアダプタにおいて、前記ハウジングが前記射出装置に取り付けられたときに前記第１筒状部と前記ノズル部の前記外周壁面との嵌合した状態を保持する保持部を、更に備えてもよい。当該保持部により第１筒状部とノズル部の外周壁面との嵌合状態が保持されることになり、射出液の移送をより良好に行い得る。 Further, in the adapter described above, further comprising a holding portion for holding a state where the first cylindrical portion and the outer peripheral wall surface of the nozzle portion are fitted when the housing is attached to the injection device. Is also good. By the holding portion, the fitting state between the first cylindrical portion and the outer peripheral wall surface of the nozzle portion is held, so that the injection liquid can be transferred more favorably.
　アダプタと射出装置の位置決めの安定性向上の観点から、前記ハウジングは、該ハウジングにおいて前記第１筒状部を囲むように設けられ、且つ、該ハウジングが前記射出装置に取り付けられたときに該射出装置の外周壁面に対して嵌合した状態となる第２筒状部を有してもよい。このような構成を採用することで、第１筒状部とノズル部との接触、及び第２筒状部と射出装置との接触の両者を介して、射出装置に対してアダプタが位置決めされることになる。その結果、アダプタの取付状態の安定性が更に増し、射出液の移送がより良好に行い得る。 From the viewpoint of improving the stability of positioning of the adapter and the injection device, the housing is provided so as to surround the first cylindrical portion in the housing, and the housing is provided when the housing is attached to the injection device. The device may have a second cylindrical portion fitted to the outer peripheral wall surface of the device. By adopting such a configuration, the adapter is positioned with respect to the injection device through both the contact between the first cylindrical portion and the nozzle portion and the contact between the second cylindrical portion and the injection device. Will be. As a result, the stability of the mounting state of the adapter is further increased, and the injection liquid can be transferred more favorably.
　また、本願発明を、射出液が収容部に収容されているアダプタから射出装置に移送する方法の側面から捉えることも可能である。すなわち、当該方法は、所定の射出液を射出ノズルから射出する射出装置に対して、該射出ノズルの射出口を介して該所定の射出液を移送するためのアダプタであって、移送される該所定の射出液を収容する収容部を画定するハウジングと、前記ハウジングにおいて前記収容部に接続して設けられ、その開口端は該収容部の内径より小さく該射出ノズルの射出口より大きく設定された充填ノズルとを備え、該充填ノズルが接続された該収容部の一部領域から該充填ノズルの開口端に至るまでの該ハウジングの内部空間のうち少なくとも該一部領域を含む連続した所定空間は、該充填ノズルの開口端側に進むに従い該所定空間の内径が縮径するように形成されたアダプタを準備し、前記射出装置に対して前記ハウジングを取り付けて、前記射出ノズルの前記射出口が形成された該射出装置の端面に前記充填ノズルの先端を接触させ、前記収容部に、前記所定の射出液を注入し、前記アダプタが前記射出装置の鉛直方向において上方に位置した状態で、前記収容部から前記所定の射出液を移し、該射出装置に対して移送する。また、上記アダプタに関連して開示した技術思想は、技術的な齟齬が生じない限りにおいて上記方法に係る発明にも適用可能である。 The invention of the present application can also be understood from the aspect of a method of transferring an injection liquid from an adapter stored in a storage unit to an injection device. That is, the method is an adapter for transferring the predetermined injection liquid through an injection port of the injection nozzle to an injection device that injects the predetermined injection liquid from the injection nozzle. A housing defining a storage portion for storing a predetermined injection liquid; and a housing connected to the storage portion in the housing, the opening end of which is set smaller than the inner diameter of the storage portion and larger than the injection port of the injection nozzle. A continuous predetermined space including at least the partial region in the internal space of the housing from the partial region of the housing portion to which the filling nozzle is connected to the opening end of the filling nozzle. Preparing an adapter formed such that the inside diameter of the predetermined space is reduced as it proceeds to the opening end side of the filling nozzle, attaching the housing to the injection device, The tip of the filling nozzle is brought into contact with the end face of the injection device in which the injection port of the chir is formed, the predetermined injection liquid is injected into the housing portion, and the adapter is upward in the vertical direction of the injection device. In the position, the predetermined injection liquid is transferred from the storage section and transferred to the injection device. The technical concept disclosed in connection with the adapter can be applied to the invention according to the method as long as no technical inconsistency arises.
　外部から無針注射器へ射出液を好適に移送することを可能とする。 と す る It is possible to preferably transfer the injection liquid from the outside to the needleless syringe.
火薬で駆動される無針注射器の概略構成を示す図である。It is a figure showing the schematic structure of the needleless syringe driven by gunpowder. 図１に示す無針注射器に組み込まれる装置組立体を構成する第１のサブ組立体の概略構成を示す図である。FIG. 2 is a diagram showing a schematic configuration of a first sub-assembly constituting a device assembly incorporated in the needleless syringe shown in FIG. 1. 図１に示す注射器に組み込まれる装置組立体を構成する第２のサブ組立体の概略構成を示す図である。FIG. 2 is a diagram showing a schematic configuration of a second sub-assembly constituting a device assembly incorporated in the syringe shown in FIG. 1. 図２Ａに示す第１のサブ組立体に対して、無針注射器によって射出される射出液を移送するために使用されるアダプタの斜視図である。FIG. 2B is a perspective view of an adapter used to transfer the injection liquid ejected by the needleless injector to the first subassembly shown in FIG. 2A. 図３に示すアダプタの断面図である。FIG. 4 is a sectional view of the adapter shown in FIG. 3. 第１のサブ組立体に対してアダプタを取り付けた状態を示す、第１の図である。FIG. 7 is a first view showing a state where an adapter is attached to the first sub-assembly. アダプタを用いた射出液の移送方法の流れを示すフローチャートである。It is a flowchart which shows the flow of the transfer method of the injection liquid using an adapter. 第１のサブ組立体に対してアダプタを取り付けた状態を示す、第２の図である。FIG. 8 is a second view showing a state where an adapter is attached to the first sub-assembly.
　以下に、図面を参照して本願発明の実施形態に係る無針注射器（以下、単に「注射器」と称する）１への射出液の移送に使用するアダプタ９０について説明する。当該注射器１は、火薬の燃焼エネルギーを利用して、本願の注射目的物質に相当する射出液を対象領域に射出する無針注射器、すなわち、注射針を介することなく、射出液を対象領域に射出して注射を行う装置である。アダプタ９０の詳細を説明する前に、注射器１について説明する。 Hereinafter, the adapter 90 used for transferring the injection liquid to the needleless syringe (hereinafter simply referred to as “syringe”) 1 according to the embodiment of the present invention will be described with reference to the drawings. The syringe 1 uses a combustion energy of an explosive to eject an injection liquid corresponding to an injection target substance of the present application into a target area, that is, a needleless syringe, that is, injects an injection liquid into a target area without passing through a syringe needle. It is a device that performs injection. Before describing the details of the adapter 90, the syringe 1 will be described.
　なお、以下の実施形態の構成は例示であり、本願発明はこの実施の形態の構成に限定されるものではない。本実施形態では、注射器１においてその長手方向における相対的な位置関係を表す用語として、「先端側」及び「基端側」を用いる。当該「先端側」は、後述する注射器１の先端寄り、すなわち射出口３１ａ寄りの位置を表し、当該「基端側」は、注射器１の長手方向において「先端側」とは反対側の方向、すなわち駆動部７側の方向を表している。また、アダプタ９０においては、射出液の移送の際の流れの下流側、すなわち図４に示す下方が「先端側」とされ、その反対側である図４に示す上方が「基端側」とされる。 The configuration of the following embodiment is an exemplification, and the present invention is not limited to the configuration of the embodiment. In the present embodiment, “distal end side” and “proximal end side” are used as terms representing the relative positional relationship in the longitudinal direction of the syringe 1. The “distal side” indicates a position near the distal end of the syringe 1 described later, that is, a position near the injection port 31a, and the “proximal side” is a direction opposite to the “distal side” in the longitudinal direction of the syringe 1, That is, the direction of the driving unit 7 is shown. Further, in the adapter 90, the downstream side of the flow during the transfer of the injection liquid, that is, the lower side shown in FIG. 4 is referred to as “distal side”, and the upper side shown in FIG. Is done.
　＜注射器１の構成＞
　ここで、図１は、注射器１の概略構成を示す図であり、注射器１のその長手方向に沿った断面図でもある。注射器１は、後述するシリンジ部３とプランジャ４とで構成されるサブ組立体（後述の図２Ａを参照）１０Ａと、注射器本体６とピストン５と駆動部７とで構成されるサブ組立体（後述の図２Ｂを参照）１０Ｂとが一体に組み立てられた装置組立体１０が、注射器ハウジング２に取り付けられることで構成される。なお、本願の以降の記載においては、注射器１により対象領域に投与される射出液は、当該対象領域で期待される効能や機能を発揮する所定物質が液体の媒体に含有されることで形成されている。その射出液において、所定物質は媒体である液体に溶解した状態となっていてもよく、また、溶解されずに単に混合された状態となっていてもよい。 <Configuration of syringe 1>
Here, FIG. 1 is a diagram showing a schematic configuration of the syringe 1 and also a cross-sectional view of the syringe 1 along the longitudinal direction. The syringe 1 includes a sub-assembly (see FIG. 2A described later) 10A including a syringe unit 3 and a plunger 4 described later, and a sub-assembly (referred to as a syringe unit 3 and a piston 5 and a driving unit 7). (See FIG. 2B described later.) The device assembly 10 in which the device assembly 10B and the device assembly 10B are integrally assembled is attached to the syringe housing 2. In the following description of the present application, the injection liquid administered to the target region by the syringe 1 is formed by including a predetermined substance exhibiting expected effects and functions in the target region in a liquid medium. ing. In the injection liquid, the predetermined substance may be dissolved in a liquid as a medium, or may be simply mixed without being dissolved.
　射出液に含まれる所定物質としては、例えば生体である対象領域に対して射出可能な生体由来物質や所望の生理活性を発する物質が例示でき、例えば、生体由来物質としては、ＤＮＡ、ＲＮＡ、核酸、抗体、細胞等が挙げられ、生理活性を発する物質としては、低分子医薬、温熱療法や放射線療法のための金属粒子等の無機物質、キャリアとなる担体を含む各種の薬理・治療効果を有する物質等が挙げられる。また、射出液の媒体である液体としては、これらの所定物質を対象領域内に投与するために好適な物質であればよく、水性、油性の如何は問われない。また、所定物質を注射器１にて射出可能であれば、媒体である液体の粘性についても特段に限定されるものではない。 Examples of the predetermined substance contained in the injection liquid include a biological substance that can be injected into a target region that is a living body and a substance that emits a desired physiological activity. Examples of the biological substance include DNA, RNA, and nucleic acid. , Antibodies, cells, and the like, and as a substance emitting a physiological activity, it has various pharmacological and therapeutic effects including a low molecular drug, an inorganic substance such as metal particles for hyperthermia or radiation therapy, and a carrier serving as a carrier. Substances and the like. In addition, the liquid serving as the medium of the injection liquid may be any substance that is suitable for administering these predetermined substances into the target region, and may be aqueous or oily. Further, as long as the predetermined substance can be injected by the syringe 1, the viscosity of the liquid as the medium is not particularly limited.
　装置組立体１０は、注射器ハウジング２に対して脱着自在となるように構成されている。装置組立体１０に含まれるシリンジ部３とプランジャ４との間に形成される収容部３２（図２Ａを参照）には、注射器１の作動前である準備段階において射出液が充填され、そして、当該装置組立体１０は、射出液の射出を行う度に交換されるユニットである。一方で、注射器ハウジング２側には、装置組立体１０の駆動部７に含まれる点火器７１に電力供給するバッテリ９が含まれている。バッテリ９からの電力供給は、ユーザが注射器ハウジング２に設けられたボタン８を押下する操作を行うことで、配線を介して注射器ハウジング２側の電極と、装置組立体１０の駆動部７側の電極との間で行われることになる。なお、注射器ハウジング２側の電極と装置組立体１０の駆動部７側の電極とは、装置組立体１０が注射器ハウジング２に取り付けられると、自動的に接触するように両電極の形状および位置が設計されている。また注射器ハウジング２は、バッテリ９に駆動部７に供給し得る電力が残っている限りにおいて、繰り返し使用することができるユニットである。そして、注射器ハウジング２においては、バッテリ９の電力が無くなった場合には、バッテリ９のみを交換し注射器ハウジング２は引き続き使用してもよい。 The device assembly 10 is configured to be detachable from the syringe housing 2. A storage part 32 (see FIG. 2A) formed between the syringe part 3 and the plunger 4 included in the device assembly 10 is filled with the injection liquid in a preparation stage before the operation of the syringe 1, and The device assembly 10 is a unit that is replaced each time the injection liquid is injected. On the other hand, a battery 9 for supplying power to an igniter 71 included in the drive unit 7 of the device assembly 10 is included on the syringe housing 2 side. The power supply from the battery 9 is performed by a user performing an operation of pressing a button 8 provided on the syringe housing 2, and the electrodes on the syringe housing 2 side and the driving unit 7 side of the device assembly 10 are connected via wiring. It will be performed between the electrodes. The electrodes on the side of the syringe housing 2 and the electrodes on the side of the drive unit 7 of the device assembly 10 are formed so that the shape and position of both electrodes are automatically contacted when the device assembly 10 is mounted on the syringe housing 2. Designed. The syringe housing 2 is a unit that can be used repeatedly as long as the power that can be supplied to the drive unit 7 remains in the battery 9. Then, in the syringe housing 2, when the power of the battery 9 is lost, only the battery 9 may be replaced and the syringe housing 2 may be used continuously.
　ここで、図２Ａ及び図２Ｂに基づいて、サブ組立体１０Ａ及び１０Ｂの構成、及び両サブ組立体に含まれるシリンジ部３、プランジャ４、ピストン５、注射器本体６、駆動部７の詳細な構成について説明する。シリンジ部３は、射出液を収容可能な空間である収容部３２を含むノズル部３１を有しているとともに、サブ組立体１０Ａにおいて収容部３２内を摺動可能となるようにプランジャ４が配置される。ノズル部３２の先端側の外周は柱状に形成されている。 Here, based on FIGS. 2A and 2B, the configuration of the sub-assemblies 10A and 10B and the detailed configuration of the syringe unit 3, the plunger 4, the piston 5, the syringe body 6, and the driving unit 7 included in both sub-assemblies Will be described. The syringe part 3 has a nozzle part 31 including a storage part 32 which is a space capable of storing the injection liquid, and the plunger 4 is arranged so as to be slidable in the storage part 32 in the sub-assembly 10A. Is done. The outer periphery on the tip side of the nozzle portion 32 is formed in a columnar shape.
　シリンジ部３のボディ３０は、例えば、公知のナイロン６－１２、ポリアリレート、ポリブチレンテレフタレート、ポリフェニレンサルファイド又は液晶ポリマー等が使用できる。また、これら樹脂にガラス繊維やガラスフィラー等の充填物を含ませてもよく、ポリブチレンテレフタレートにおいては２０～８０質量％のガラス繊維を、ポリフェニレンサルファイドにおいては２０～８０質量％のガラス繊維を、また液晶ポリマーにおいては２０～８０質量％のミネラルを含ませることができる。 For the body 30 of the syringe unit 3, for example, known nylon 6-12, polyarylate, polybutylene terephthalate, polyphenylene sulfide, liquid crystal polymer, or the like can be used. These resins may also contain fillers such as glass fibers and glass fillers. For polybutylene terephthalate, 20 to 80% by mass of glass fibers, for polyphenylene sulfide, 20 to 80% by mass of glass fibers, Further, the liquid crystal polymer may contain 20 to 80% by mass of mineral.
　そして、そのボディ３０の内部に形成された収容部３２においてプランジャ４がノズル部３１方向（先端側方向）に摺動可能となるように配置され、プランジャ４とシリンジ部３のボディとの間に形成される空間が、射出液３２０が封入される空間となる。なお、この射出液３２０は、図３等に記載のアダプタ９０を用いて収容部３２内に移送されるが、その詳細については後述する。ここで、収容部３２内をプランジャ４が摺動することで、収容部３２に収容されている射出液３２０が押圧されて、ノズル部３１の先端側に設けられた射出ノズル３１ｂを通って、射出口３１ａより射出されることになる。射出口３１ａは、ノズル部３１の先端側の端面（先端面）３１ｃにおいて開口している。なお、先端面３１ｃは、射出口３１ａを除けば略平面である。 The plunger 4 is arranged so as to be slidable in the direction of the nozzle 31 (in the direction toward the tip end) in the housing portion 32 formed inside the body 30, and between the plunger 4 and the body of the syringe 3. The formed space is a space in which the injection liquid 320 is sealed. The injection liquid 320 is transferred into the storage section 32 by using the adapter 90 shown in FIG. 3 and the like, and details thereof will be described later. Here, when the plunger 4 slides in the storage portion 32, the injection liquid 320 stored in the storage portion 32 is pressed and passes through the injection nozzle 31 b provided on the tip side of the nozzle portion 31. It will be injected from the injection port 31a. The injection port 31a is open at an end face (tip face) 31c on the tip side of the nozzle portion 31. The tip surface 31c is substantially flat except for the injection port 31a.
　プランジャ４は、収容部３２内での摺動が円滑であり、且つ、射出液３２０がプランジャ４側から漏出しないような材質で形成される。具体的なプランジャ４の材質としては、例えば、ブチルゴムやシリコンゴムが採用できる。更には、スチレン系エラストマー、水添スチレン系エラストマーや、これにポリエチレン、ポリプロピレン、ポリブテン、α－オレフィン共重合体等のポリオレフィンや流パラ、プロセスオイル等のオイルやタルク、キャスト、マイカ等の粉体無機物を混合したものがあげられる。さらにポリ塩化ビニル系エラストマー、オレフィン系エラストマー、ポリエステル系エラストマー、ポリアミド系エラストマー、ポリウレタン系エラストマーや天然ゴム、イソプレンゴム、クロロプレンゴム、ニトリル－ブタジエンゴム、スチレン－ブタジエンゴムのような各種ゴム材料（特に加硫処理したもの）や、それらの混合物等を、プランジャ４の材質として採用することもできる。また、プランジャ４とシリンジ部３との間の摺動性を確保・調整する目的で、プランジャ４の表面やシリンジ部３の収容部３２の表面を各種物質によりコーティング・表面加工してもよい。そのコーティング剤としては、ＰＴＦＥ（ポリテトラフルオロエチレン）、シリコンオイル、ダイヤモンドライクカーボン、ナノダイヤモンド等が利用できる。 The plunger 4 is made of a material that slides smoothly in the housing portion 32 and does not leak the injection liquid 320 from the plunger 4 side. As a specific material of the plunger 4, for example, butyl rubber or silicon rubber can be adopted. Further, styrene-based elastomers, hydrogenated styrene-based elastomers, and polyolefins such as polyethylene, polypropylene, polybutene, α-olefin copolymers and the like, oils such as process oils, process oils and the like, and powders such as talc, cast and mica What mixed the inorganic substance is mentioned. Further, various rubber materials such as polyvinyl chloride elastomer, olefin elastomer, polyester elastomer, polyamide elastomer, polyurethane elastomer, natural rubber, isoprene rubber, chloroprene rubber, nitrile-butadiene rubber, and styrene-butadiene rubber (particularly, Sulfurized products), mixtures thereof, and the like can also be employed as the material of the plunger 4. Further, the surface of the plunger 4 and the surface of the housing portion 32 of the syringe unit 3 may be coated and processed with various substances in order to secure and adjust the slidability between the plunger 4 and the syringe unit 3. As the coating agent, PTFE (polytetrafluoroethylene), silicon oil, diamond-like carbon, nanodiamond and the like can be used.
　ここで、プランジャ４は、図２Ａに示すように、頭部４１と胴部４２を有し、両者の間は頭部４１及び胴部４２の直径よりも小さく径を有する首部４３で繋がれているものとすることができる。このように首部４３の直径を小さくするのは、シール部材となるＯリングの収容空間を形成するためである。なお、頭部４１の先端側の輪郭は、ノズル部３１の内壁面の輪郭に概ね一致する形状となっている。これにより、射出液の射出時にプランジャ４がノズル部３１側に摺動し、収容部３２において最も奥に位置する最奥位置に到達したときに、プランジャ４とノズル部３１の内壁面との間に形成される隙間を可及的に小さくでき、射出液３２０が収容部３２内に残り無駄となることを抑制することができる。ただし、プランジャ４の形状は、本実施形態の注射器において所望の効果が得られる限りにおいて、特定の形状に限定されるものではない。 Here, as shown in FIG. 2A, the plunger 4 has a head 41 and a body 42, and the two are connected by a neck 43 having a diameter smaller than the diameter of the head 41 and the body 42. You can be. The reason why the diameter of the neck portion 43 is reduced in this way is to form an accommodation space for an O-ring serving as a seal member. Note that the contour on the tip end side of the head 41 has a shape that substantially matches the contour of the inner wall surface of the nozzle portion 31. Thereby, when the plunger 4 slides toward the nozzle portion 31 at the time of injection of the injection liquid, and reaches the deepest position located at the deepest position in the housing portion 32, the plunger 4 and the inner wall surface of the nozzle portion 31 are moved. Can be reduced as much as possible, and it is possible to prevent the injection liquid 320 from remaining in the storage portion 32 and being wasted. However, the shape of the plunger 4 is not limited to a specific shape as long as a desired effect is obtained in the syringe of the present embodiment.
　更に、プランジャ４には、胴部４２の基端側の端面から、更に基端側の方向に延在するロッド部４４が設けられている。このロッド部４４は胴部４２と比べて十分にその直径は小さいが、ユーザが当該ロッド部４４を把持して収容部３２内を移動させることが可能な程度の直径を有している。ユーザは、射出液を収容部３２に移送する際に、このロッド部４４を把持してプランジャ４を動かすことで、外部から射出液を収容部３２内に吸い込む。また、プランジャ４がシリンジ部３の収容部３２の最奥位置にある場合でも、ロッド部４４がシリンジ部３の基端側の端面から突出し、ユーザが当該ロッド部４４を把持できるように、ロッド部４４の長さが決定されている。 ロ ッ ド Furthermore, the plunger 4 is provided with a rod portion 44 extending from the end face on the base end side of the body section 42 to the direction further on the base end side. Although the diameter of the rod portion 44 is sufficiently smaller than the diameter of the body portion 42, the rod portion 44 has a diameter that allows a user to grip the rod portion 44 and move the inside of the housing portion 32. When transferring the injection liquid to the storage section 32, the user sucks the injection liquid into the storage section 32 from outside by gripping the rod portion 44 and moving the plunger 4. Further, even when the plunger 4 is located at the innermost position of the housing portion 32 of the syringe portion 3, the rod portion 44 projects from the proximal end surface of the syringe portion 3 so that the user can grip the rod portion 44. The length of the part 44 is determined.
　ここで、シリンジ部３の説明に戻る。シリンジ部３側のノズル部３１に設けられた射出ノズル３１ｂの内径は、収容部３２の内径よりも細く形成されている。このような構成により、高圧に加圧された射出液３２０が、射出ノズル３１ｂの射出口３１ａから外部に射出されることになる。また、シリンジ部３の基端側に位置する首部３３には、後述するサブ組立体１０Ｂ側の注射器本体６とシリンジ部３とを結合するためのネジ部３３ａが形成されている。この首部３３の直径は、ボディ３０の直径よりも小さく設定されている。 に Here, the description returns to the syringe section 3. The inner diameter of the injection nozzle 31b provided in the nozzle part 31 on the syringe part 3 side is formed smaller than the inner diameter of the housing part 32. With such a configuration, the injection liquid 320 pressurized to a high pressure is injected outside from the injection port 31a of the injection nozzle 31b. Further, a screw portion 33a for connecting the syringe body 6 and the syringe portion 3 on the sub-assembly 10B side described later is formed in the neck portion 33 located on the proximal end side of the syringe portion 3. The diameter of the neck 33 is set smaller than the diameter of the body 30.
　次に、ピストン５、注射器本体６、駆動部７を含むサブ組立体１０Ｂについて図２Ｂに基づいて説明する。ピストン５は、駆動部７の点火器７１で生成される燃焼生成物により加圧されて、注射器本体６のボディ６０の内部に形成されている貫通孔６４内を摺動するように構成されている。ここで、注射器本体６には、貫通孔６４を基準として、先端側に結合凹部６１が形成されている。この結合凹部６１は、上記のシリンジ部３の首部３３と結合する部位であり、首部３３に設けられたネジ部３３ａと螺合するネジ部６２ａが、結合凹部６１の側壁面６２上に形成されている。また、貫通孔６４と結合凹部６１とは、連通部６３によって繋がれているが、連通部６３の直径は、貫通孔６４の直径よりも小さく設定されている。また、注射器本体６には、貫通孔６４を基準として、基端側に駆動部用凹部６５が形成されている。この駆動部用凹部６５に駆動部７が配置されることになる。 Next, the subassembly 10B including the piston 5, the syringe main body 6, and the driving unit 7 will be described with reference to FIG. 2B. The piston 5 is configured to be pressurized by a combustion product generated by the igniter 71 of the drive unit 7 and slide in a through hole 64 formed inside the body 60 of the syringe body 6. I have. Here, a coupling recess 61 is formed on the distal end side of the syringe body 6 with reference to the through hole 64. The coupling concave portion 61 is a portion that is coupled to the neck portion 33 of the syringe portion 3, and a screw portion 62 a that is screwed with a screw portion 33 a provided on the neck portion 33 is formed on a side wall surface 62 of the coupling concave portion 61. ing. The through hole 64 and the coupling concave portion 61 are connected by a communication portion 63, and the diameter of the communication portion 63 is set smaller than the diameter of the through hole 64. In addition, a recess 65 for a drive unit is formed on the base end side of the syringe body 6 with reference to the through hole 64. The drive unit 7 is arranged in the drive unit recess 65.
　また、ピストン５は、金属製であり、第１胴部５１及び第２胴部５２を有している。第１胴部５１が結合凹部６１側に、且つ第２胴部５２が駆動部用凹部６５側に向くように、ピストン５は貫通孔６４内に配置される。この第１胴部５１及び第２胴部５２が、注射器本体６の貫通孔６４の内壁面と対向しながら、ピストン５は貫通孔６４内を摺動する。なお、第１胴部５１と第２胴部５２との間は、各胴部の直径より細い連結部で繋がれており、その結果形成される両胴部間の空間には、貫通孔６４の内壁面との密着性を高めるために、Ｏリング等が配置される。また、ピストン５は樹脂製でもよく、その場合、耐熱性や耐圧性が要求される部分は金属を併用してもよい。 The piston 5 is made of metal, and has a first body 51 and a second body 52. The piston 5 is arranged in the through hole 64 such that the first body 51 faces the coupling recess 61 and the second body 52 faces the drive unit recess 65. The piston 5 slides in the through hole 64 while the first body 51 and the second body 52 face the inner wall surface of the through hole 64 of the syringe body 6. The first trunk portion 51 and the second trunk portion 52 are connected by a connecting portion smaller than the diameter of each trunk portion, and a space formed between the two trunk portions is formed with a through hole 64. An O-ring or the like is arranged in order to increase the adhesion to the inner wall surface. Further, the piston 5 may be made of a resin, and in that case, a portion requiring heat resistance and pressure resistance may use a metal together.
　ここで、第１胴部５１の先端側の端面には、第１胴部５１より直径が小さく、且つ、注射器本体６の連通部６３の直径よりも小さい直径を有する押圧柱部５３が設けられている。この押圧柱部５３には、その先端側の端面に開口し、その直径がロッド部４４の直径以上であり、且つ、その深さがロッド部４４の長さより深い収容孔５４が設けられている。そのため、押圧柱部５３は、その先端側の端面を介して、ピストン５が点火器７１の燃焼生成物により加圧されたときにその燃焼エネルギーをプランジャ４の胴部４２の基端側の端面に伝えることが可能となる。なお、ピストン５の形状も図２Ｂに記載の形状に限定されるものではない。 Here, a pressing pillar 53 having a smaller diameter than the first body 51 and a diameter smaller than the diameter of the communication part 63 of the syringe body 6 is provided on an end surface on the distal end side of the first body 51. ing. The pressing column portion 53 is provided with a receiving hole 54 which is open at the end face on the distal end side, the diameter of which is greater than the diameter of the rod portion 44, and whose depth is greater than the length of the rod portion 44. . Therefore, when the piston 5 is pressurized by the combustion product of the igniter 71, the pressing column portion 53 transfers the combustion energy via the end surface on the distal end side to the proximal end surface of the body portion 42 of the plunger 4. It is possible to tell. The shape of the piston 5 is not limited to the shape shown in FIG. 2B.
　次に、駆動部７について説明する。駆動部７は、そのボディ７２が筒状に形成され、その内部に、点火薬を燃焼させて射出のためのエネルギーを発生させる電気式点火器である点火器７１を有し、点火器７１による燃焼エネルギーをピストン５の第２胴部５２に伝えられるように、上記の通り駆動部用凹部６５に配置される。詳細には、駆動部７のボディ７２は、射出成形した樹脂を金属のカラーに固定したものであってもよい。当該射出成形については、公知の方法を使用することができる。駆動部７のボディ７２の樹脂材料としては、シリンジ部３のボディ３０と同じ樹脂材料で形成されている。 Next, the driving unit 7 will be described. The drive unit 7 has an igniter 71 which is an electric igniter that has a body 72 formed in a cylindrical shape and burns an igniter to generate energy for injection. As described above, the combustion energy is arranged in the drive unit concave portion 65 so that the combustion energy is transmitted to the second body portion 52 of the piston 5. More specifically, the body 72 of the drive unit 7 may be formed by fixing injection-molded resin to a metal collar. For the injection molding, a known method can be used. The resin material of the body 72 of the drive unit 7 is formed of the same resin material as the body 30 of the syringe unit 3.
　ここで、点火器７１において用いられる点火薬の燃焼エネルギーは、注射器１が射出液を対象領域に射出するためのエネルギーとなる。なお、当該点火薬としては、好ましくは、ジルコニウムと過塩素酸カリウムを含む火薬（ＺＰＰ）、水素化チタンと過塩素酸カリウムを含む火薬（ＴＨＰＰ）、チタンと過塩素酸カリウムを含む火薬（ＴｉＰＰ）、アルミニウムと過塩素酸カリウムを含む火薬（ＡＰＰ）、アルミニウムと酸化ビスマスを含む火薬（ＡＢＯ）、アルミニウムと酸化モリブデンを含む火薬（ＡＭＯ）、アルミニウムと酸化銅を含む火薬（ＡＣＯ）、アルミニウムと酸化鉄を含む火薬（ＡＦＯ）、もしくはこれらの火薬のうちの複数の組合せからなる火薬が挙げられる。これらの火薬は、点火直後の燃焼時には高温高圧のプラズマを発生させるが、常温となり燃焼生成物が凝縮すると気体成分を含まないために発生圧力が急激に低下する特性を示す。適切な射出液の射出が可能な限りにおいて、これら以外の火薬を点火薬として用いても構わない。 Here, the combustion energy of the igniter used in the igniter 71 is energy for the injector 1 to inject the injection liquid into the target area. The igniting charge is preferably an explosive containing zirconium and potassium perchlorate (ZPP), an explosive containing titanium hydride and potassium perchlorate (THPP), or an explosive containing titanium and potassium perchlorate (TiPP). ), Gunpowder containing aluminum and potassium perchlorate (APP), gunpowder containing aluminum and bismuth oxide (ABO), gunpowder containing aluminum and molybdenum oxide (AMO), gunpowder containing aluminum and copper oxide (ACO), aluminum An explosive containing iron oxide (AFO), or an explosive consisting of a combination of a plurality of these explosives is exemplified. These explosives generate high-temperature and high-pressure plasma during combustion immediately after ignition, but exhibit a characteristic that when they reach room temperature and combustion products condense, they do not contain gaseous components and the generated pressure drops rapidly. Other explosives may be used as the igniting charge as long as an appropriate injection liquid can be injected.
　また、注射器１では、ピストン５を介して射出液にかける圧力推移を調整するために、上記点火薬に加えて、点火器７１での火薬燃焼によって生じる燃焼生成物によって燃焼しガスを発生させるガス発生剤８０が配置されている。その配置場所は、例えば、図１や図２Ｂに示されるように、点火器７１からの燃焼生成物に晒され得る場所である。また、別法としてガス発生剤８０を、国際公開公報０１－０３１２８２号や特開２００３－２５９５０号公報等に開示されているように、点火器７１内に配置してもよい。ガス発生剤の一例としては、ニトロセルロース９８質量％、ジフェニルアミン０．８質量％、硫酸カリウム１．２質量％からなるシングルベース無煙火薬が挙げられる。また、エアバッグ用ガス発生器やシートベルトプリテンショナ用ガス発生器に使用されている各種ガス発生剤を用いることも可能である。貫通孔６４内に配置されるときのガス発生剤の寸法や大きさ、形状、特に表面形状を調整することで、該ガス発生剤の燃焼完了時間を変化させることが可能であり、これにより、射出液に掛ける圧力推移を調整し、その射出圧を所望の推移とすることができる。 In addition, in the injector 1, in order to adjust the transition of the pressure applied to the injection liquid via the piston 5, in addition to the above-mentioned igniter, a gas generated by combustion by the combustion product generated by the explosive combustion in the igniter 71 generates gas. A generator 80 is provided. The location is, for example, a location that can be exposed to combustion products from the igniter 71 as shown in FIGS. 1 and 2B. Alternatively, the gas generating agent 80 may be disposed in the igniter 71 as disclosed in International Publication WO 01-031282, JP 2003-25950 A, and the like. An example of the gas generating agent is a single-base smokeless explosive comprising 98% by mass of nitrocellulose, 0.8% by mass of diphenylamine, and 1.2% by mass of potassium sulfate. It is also possible to use various gas generating agents used in gas generators for airbags and gas generators for seatbelt pretensioners. By adjusting the size, size, and shape, particularly the surface shape of the gas generating agent when arranged in the through hole 64, it is possible to change the combustion completion time of the gas generating agent, By adjusting the transition of the pressure applied to the injection liquid, the injection pressure can be set to a desired transition.
　なお、サブ組立体１０Ａへの射出液３２０の移送は、図３に示すアダプタ９０を用いて行われる。そして、サブ組立体１０Ａにおいてその射出液３２０の移送が完了した状態では、例えば、図２Ａに示すように、プランジャ４の胴部４２の基端側の端面が、シリンジ部３の基端側の端面より若干飛び出した位置に至るまで、プランジャ４は引き出されている。 The transfer of the injection liquid 320 to the sub-assembly 10A is performed using the adapter 90 shown in FIG. In the state where the transfer of the injection liquid 320 is completed in the sub-assembly 10A, for example, as shown in FIG. 2A, the proximal end surface of the body portion 42 of the plunger 4 is connected to the proximal end surface of the syringe portion 3. The plunger 4 is pulled out to a position slightly protruding from the end face.
　またサブ組立体１０Ｂでは、先ず、図２Ｂに示す注射器本体６の基端側からピストン５が挿入される。このとき、押圧柱部５３が結合凹部６１側を向くように、ピストン５が貫通孔６４に挿入される。そして、ピストン５の先端側の端面、すなわち収容孔５４が開口する押圧柱部５３の先端側の端面が、結合凹部６１の底面（側壁面６２に直交する面）より所定量飛び出した状態となるように位置決めされる。ピストン５の位置決めについては、貫通孔６４内に位置決めのためのマークを設定する、位置決め用の治具を使用するなど、公知の技術を適宜利用すればよい。そして、貫通孔６４内にガス発生剤８０が配置されるとともに駆動部用凹部６５に駆動部７が取り付けられる。なお、ピストン５の貫通孔６４における固定力は、駆動部７の点火器７１による燃焼生成物から受ける圧力によっては、ピストン５が十分に円滑に貫通孔６４内を摺動できる程度であり、且つ、サブ組立体１０Ａがサブ組立体１０Ｂに取り付けられる際にピストン５がプランジャ４から受ける力に対しては十分に抗し、ピストン５の位置が変動しない程度とされる。 In the subassembly 10B, first, the piston 5 is inserted from the proximal end side of the syringe main body 6 shown in FIG. 2B. At this time, the piston 5 is inserted into the through-hole 64 such that the pressing pillar 53 faces the coupling recess 61. Then, the end face on the tip end side of the piston 5, that is, the end face on the tip end side of the pressing column portion 53 in which the housing hole 54 is opened, is in a state of protruding a predetermined amount from the bottom surface (the surface orthogonal to the side wall surface 62) of the coupling recess 61. Is positioned as follows. As for the positioning of the piston 5, a known technique such as setting a mark for positioning in the through hole 64 or using a positioning jig may be appropriately used. Then, the gas generating agent 80 is arranged in the through hole 64 and the driving unit 7 is attached to the driving unit concave portion 65. The fixing force of the piston 5 in the through-hole 64 is such that the piston 5 can slide in the through-hole 64 sufficiently and smoothly depending on the pressure received from the combustion product by the igniter 71 of the drive unit 7. When the sub-assembly 10A is attached to the sub-assembly 10B, the piston 5 sufficiently resists the force received from the plunger 4, and the position of the piston 5 does not fluctuate.
　このように構成されるサブ組立体１０Ａが、ネジ部３３ａと６２ａの螺合によりサブ組立体１０Ｂに取り付けられることで、装置組立体１０が形成されることになる。このとき、両者の結合が進んでいくと、ピストン５の押圧柱部５３に設けられた収容孔５４内に、プランジャ４のロッド部４４が進入していき収容された状態となり、最終的には、押圧柱部５３の先端側の端面が、プランジャ４の胴部４２の基端側の端面に接触した状態となる。なお、収容孔５４はロッド部４４を収容するのに十分な大きさを有しているため、この接触状態において、収容孔５４の奥の内壁面（特に、収容孔５４の底面）はロッド部４４の基端側の端部には接触しておらず、したがってロッド部４４はピストン５側から荷重を受けてはいない。更に、最終の螺合位置まで進めていくと、上記の通りピストン５は貫通孔６４に十分な摩擦力でその位置が固定されているため、押圧柱部５３によりプランジャ４が射出口３１ａ側に進むように押され、シリンジ部３内においてプランジャ４が位置決めされる。なお、このプランジャ４の押し出し量に応じた射出液３２０の一部が、射出口３１ａから吐出される。 The apparatus assembly 10 is formed by attaching the sub-assembly 10A thus configured to the sub-assembly 10B by screwing the screw portions 33a and 62a. At this time, as the coupling between the two progresses, the rod portion 44 of the plunger 4 enters and is housed in the housing hole 54 provided in the pressing column portion 53 of the piston 5, and finally, is housed. Thus, the end surface on the distal end side of the pressing pillar 53 comes into contact with the end surface on the proximal end side of the body 42 of the plunger 4. Since the accommodation hole 54 is large enough to accommodate the rod portion 44, in this contact state, the inner wall surface at the back of the accommodation hole 54 (particularly, the bottom surface of the accommodation hole 54) is No contact is made with the proximal end of the rod 44, so that the rod portion 44 does not receive a load from the piston 5 side. When the piston 5 is further advanced to the final screwing position, the position of the piston 5 is fixed to the through hole 64 with a sufficient frictional force as described above, so that the plunger 4 is moved toward the injection port 31a by the pressing column 53. The plunger 4 is positioned in the syringe section 3 by being pushed forward. In addition, a part of the injection liquid 320 corresponding to the amount of pushing of the plunger 4 is discharged from the injection port 31a.
　このようにプランジャ４が最終位置に位置決めされると、装置組立体１０の形成が完了することになる。この装置組立体１０においては、注射器本体６に対してピストン５は所定の位置に位置決めされた状態であり、そのピストン５を基準としてシリンジ部３の収容部３２におけるプランジャ４の位置が機械的に最終的に決定される。このプランジャ４の最終的な位置は、装置組立体１０において一義的に決定される位置であるから、最終的に収容部３２内に収容される射出液３２０の量を、予め決められた所定量とすることが可能となる。 と When the plunger 4 is positioned at the final position, the formation of the device assembly 10 is completed. In this device assembly 10, the piston 5 is positioned at a predetermined position with respect to the syringe main body 6, and the position of the plunger 4 in the housing portion 32 of the syringe unit 3 is mechanically determined based on the piston 5. It is finally decided. Since the final position of the plunger 4 is a position uniquely determined in the apparatus assembly 10, the amount of the injection liquid 320 finally stored in the storage portion 32 is reduced to a predetermined amount. It becomes possible.
　そして、当該装置組立体１０は注射器ハウジング２に取り付けられて、ユーザにより射出口３１ａを対象領域に接触させた状態でボタン８が押下されることで、ピストン５、プランジャ４を介して、射出液３２０が加圧され、その射出が実行され、対象領域内に射出液３２０が注射されることになる。 Then, the device assembly 10 is attached to the syringe housing 2, and when the user presses the button 8 in a state where the injection port 31 a is in contact with the target area, the injection liquid is injected through the piston 5 and the plunger 4. 320 is pressurized, its injection is performed, and injection liquid 320 is injected into the target area.
　＜射出液の収容部３２への移送＞
　上述のように、注射器１を作動する前に、ユーザは、サブ組立体１０Ａを及びサブ組立体１０Ｂを組み立てる必要があり、特にサブ組立体１０Ａの組立においては、ユーザは当初空である収容部３２に射出液を外部から移送する必要がある。本実施形態では、この射出液の移送に、図３に示すアダプタ９０が使われる。以降、アダプタ９０を用いた射出液の移送について、詳細に説明する。 <Transfer of the injection liquid to the storage section 32>
As described above, before operating the syringe 1, the user needs to assemble the sub-assembly 10A and the sub-assembly 10B. It is necessary to transfer the injection liquid to the outside 32. In the present embodiment, an adapter 90 shown in FIG. 3 is used for transferring the injection liquid. Hereinafter, transfer of the injection liquid using the adapter 90 will be described in detail.
　先ず、図３～図５に基づいて、アダプタ９０の構成について説明する。図３は、アダプタ９０の斜視図であり、図４は、アダプタ９０の断面図である。また、図５は、アダプタ９０の使用状態を表す図であり、アダプタ９０を用いて射出液を注射器１のサブ組立体１０Ａに移送する場合、サブ組立体１０Ａに対してアダプタ９０が取り付けられた状態となる。 First, the configuration of the adapter 90 will be described with reference to FIGS. FIG. 3 is a perspective view of the adapter 90, and FIG. 4 is a sectional view of the adapter 90. FIG. 5 is a diagram illustrating a usage state of the adapter 90. When the injection liquid is transferred to the subassembly 10A of the syringe 1 using the adapter 90, the adapter 90 is attached to the subassembly 10A. State.
　アダプタ９０は、その本体を形成するハウジング９９を有する。ハウジング９９は、射出成形された所定の樹脂材料によって形成されている。当該射出成形については、公知の方法を使用することができる。例えば、アダプタ９０の樹脂材料としては、シリンジ部３のボディ３０と同じ樹脂材料であり、例えば、例えば、公知のナイロン６－１２、ポリアリレート、ポリブチレンテレフタレート、ポリフェニレンサルファイド又は液晶ポリマー等が使用できる。なお、後述するようにアダプタ９０に含まれる突起部９２ｂに好適な可撓性が付与されるように、シリンジ部３のボディ３０と比較して、樹脂材料の硬度に関する所定のパラメータ（例えば、ビッカース硬さ）に基づいてより硬度の低い材料を採用できる。また、突起部９２ｂの材料は、ハウジング９９の材料と異なってもよく、例えばハウジング９９の材料にポリプロピレンを採用し、突起部９２ｂの材料にはシリコンゴムを採用できる。 Adapter 90 has a housing 99 forming its body. The housing 99 is formed of a predetermined resin material that is injection-molded. For the injection molding, a known method can be used. For example, the resin material of the adapter 90 is the same as the resin material of the body 30 of the syringe unit 3. For example, known nylon 6-12, polyarylate, polybutylene terephthalate, polyphenylene sulfide, liquid crystal polymer, or the like can be used. . In addition, as described later, a predetermined parameter (for example, Vickers) related to the hardness of the resin material is compared with the body 30 of the syringe unit 3 so that the protrusion 92b included in the adapter 90 is provided with suitable flexibility. (Hardness), a material having lower hardness can be adopted. The material of the protrusion 92b may be different from the material of the housing 99. For example, polypropylene may be used as the material of the housing 99, and silicon rubber may be used as the material of the protrusion 92b.
　ハウジング９９は、図４に示す状態において上方に位置する上側周壁部９１、その上側周壁部９１に対して繋がった鍔部９４、その鍔部９４の下方に位置するように鍔部９４に対して繋がった下側周壁部９５を有する。これらの上側周壁部９１、鍔部９４、下側周壁部９５は、図３に示すようにアダプタ９０の外部から視認が可能な部位である。そして、上側周壁部９１は、鍔部９４から上方に進むに従って上側周壁部９１がアダプタ９０の中心軸Ｌ１に近づくようにテーパした状態で鍔部９４と繋がった略筒状形状を有している。そのため、上側周壁部９１によって、ハウジング９９の内部に所定の空間９９ａが画定される。この所定の空間９９ａは、射出液が収容される収容部９９ａとして機能する。収容部９９ａは、後述するようにその下方において充填ノズル９２と接続しており、その接続部位を含む収容部９９ａの下方の一部領域Ｒ１の内径は、上側から下側（充填ノズル９２側）に進むに従って小さくなるように、収容部９９ａは形成されている。 The housing 99 has an upper peripheral wall portion 91 located above in the state shown in FIG. 4, a flange 94 connected to the upper peripheral wall portion 91, and a flange 94 positioned below the flange 94. It has a lower peripheral wall 95 connected thereto. The upper peripheral wall portion 91, the flange portion 94, and the lower peripheral wall portion 95 are portions that can be visually recognized from the outside of the adapter 90 as shown in FIG. The upper peripheral wall portion 91 has a substantially cylindrical shape connected to the flange portion 94 in a state where the upper peripheral wall portion 91 is tapered so as to approach the central axis L1 of the adapter 90 as it goes upward from the flange portion 94. . Therefore, a predetermined space 99 a is defined inside the housing 99 by the upper peripheral wall portion 91. The predetermined space 99a functions as a storage section 99a for storing the injection liquid. The accommodation portion 99a is connected to the filling nozzle 92 below the accommodation portion 99a, as described later. The accommodating portion 99a is formed so as to become smaller as going to.
　更に、上側周壁部９１の内部において、収容部９９ａの下方に位置し、収容部９９ａと連通している充填ノズル９２が設けられている。充填ノズル９２は、上側周壁部９１の内壁面の一部が、その内部空間を狭めるようにアダプタ９０の先端側に向かって環状に突出することで形成される突起部を有する。そのため、充填ノズル９２の最上端（基端）は収容部９９ａと連通しており、その最上端における充填ノズル９２の内径は、接続する収容部９９ａの最下端の内径と一致する。一方で、充填ノズル９２の最下端（先端）、すなわち当該突起部の先端部には開口端９２ａが形成され、開口端９２ａの内径は、収容部９９ａの内径、特に、収容部９９ａにおいて最も内径が小さい、上記最下端での内径よりも小さく設定されている。そして、充填ノズル９２においては、その内径は、その最上端から最下端である開口端９２ａに進むに従って小さくなるように、充填ノズル９２が形成されている。このように充填ノズル９２の内部空間においては、収容部９９ａに収容された射出液が流れ込む流路が形成されており、その射出液は、開口端９２ａを通ってハウジング９９内を更に下方に移動することができる。 Further, inside the upper peripheral wall portion 91, a filling nozzle 92 is provided below the housing portion 99a and communicates with the housing portion 99a. The filling nozzle 92 has a projection formed by partly protruding toward the distal end side of the adapter 90 so that a part of the inner wall surface of the upper peripheral wall portion 91 narrows its internal space. Therefore, the uppermost end (base end) of the filling nozzle 92 communicates with the housing portion 99a, and the inner diameter of the filling nozzle 92 at the uppermost end matches the innermost diameter of the lowermost end of the housing portion 99a to be connected. On the other hand, an opening end 92a is formed at the lowermost end (tip) of the filling nozzle 92, that is, at the tip of the projection, and the inside diameter of the opening end 92a is the inside diameter of the accommodation portion 99a, particularly, the inside diameter of the accommodation portion 99a. Is smaller than the inner diameter at the lowermost end. In the filling nozzle 92, the filling nozzle 92 is formed such that the inner diameter decreases from the uppermost end to the open end 92a, which is the lowermost end. As described above, in the internal space of the filling nozzle 92, a flow path into which the injection liquid stored in the storage portion 99a flows is formed, and the injection liquid moves further downward in the housing 99 through the opening end 92a. can do.
　また、充填ノズル９２の外周において中腹から下方に向かって延在する、筒状の筒状部９３が設けられている。筒状部９３の内壁面９３ａは、アダプタ９０の中心軸Ｌ１と概ね平行となっている。筒状部９３は、第１筒状部に相当する。この内壁面９３ａによって画定される内部空間の内径は、シリンジ部３のボディ３０における先端部（図２Ａで示す状態において、最も左側に位置する部分）に位置する柱状のノズル部３１の外径に対応し、好ましくは概ね一致する。そして、充填ノズル９２において、筒状部９３が設けられている場所から充填ノズル９２の先端部までの部位を突起部９２ｂとする。突起部９２ｂは、筒状部９３の内部空間に環状に突出した状態となっており、突起部９２ｂの先端側の端縁によって充填ノズル９２の開口端９２ａが画定されることになる。突起部９２ｂの長さ（又は、中心軸Ｌ１に沿った方向の高さ）は、開口端９２ａが筒状部９３の内部空間に十分に収まる程度であり、換言すれば、突起部９２ｂの先端部から下方に筒状部９３が十分に延在している状態が確保される程度である。 筒 Further, on the outer periphery of the filling nozzle 92, there is provided a cylindrical tubular portion 93 extending downward from the middle. The inner wall surface 93a of the tubular portion 93 is substantially parallel to the center axis L1 of the adapter 90. The tubular portion 93 corresponds to a first tubular portion. The inner diameter of the internal space defined by the inner wall surface 93a is equal to the outer diameter of the columnar nozzle portion 31 located at the tip (the leftmost portion in the state shown in FIG. 2A) of the body 30 of the syringe portion 3. Corresponding, and preferably substantially coincident. In the filling nozzle 92, a portion from the position where the tubular portion 93 is provided to the tip of the filling nozzle 92 is referred to as a protrusion 92b. The protruding portion 92b is annularly protruding into the internal space of the cylindrical portion 93, and the opening end 92a of the filling nozzle 92 is defined by the edge of the protruding portion 92b on the tip side. The length of the protrusion 92b (or the height in the direction along the central axis L1) is such that the opening end 92a is sufficiently accommodated in the internal space of the cylindrical portion 93, in other words, the tip of the protrusion 92b. This is a degree that ensures a state in which the cylindrical portion 93 extends sufficiently downward from the portion.
　次に、鍔部９４は、上側周壁部９１の最下端の端部で接続され、図４に示すように中心軸Ｌ１に直交する平面部材である。また、下側周壁部９５は、鍔部９４に対して直交するように設けられた筒状の部材であり、その内壁面９５ａはアダプタ９０の中心軸Ｌ１と概ね平行となっている。当該下側周壁部９５は、第２筒状部に相当する。この内壁面９５ａによって画定される内部空間の内径は、シリンジ部３のボディ３０における中腹部（図２Ａで示す状態において、ノズル部３１が位置する先端部とネジ部３３ａが設けられている基端部との間の部分であり、ボディ３０において最も太い部分）の外径に対応し、好ましくは概ね一致する。したがって、内壁面９５ａによる内部空間の内径は、上記の内壁面９３ａによる内部空間の内径よりも大きい。また、内壁面９５ａによる内部空間は、ハウジング９９内において、上側周壁部９１による内部空間と連通している。ただし、筒状部９３は、内壁面９５ａによる内部空間には至ってはいない。 Next, the flange portion 94 is a flat member connected at the lowermost end of the upper peripheral wall portion 91 and orthogonal to the central axis L1 as shown in FIG. The lower peripheral wall portion 95 is a cylindrical member provided so as to be orthogonal to the flange portion 94, and an inner wall surface 95 a thereof is substantially parallel to the center axis L 1 of the adapter 90. The lower peripheral wall portion 95 corresponds to a second cylindrical portion. The inner diameter of the inner space defined by the inner wall surface 95a is the middle portion of the body 30 of the syringe portion 3 (in the state shown in FIG. 2A, the tip portion where the nozzle portion 31 is located and the base end where the screw portion 33a is provided). Portion, which corresponds to the outer diameter of the thickest part of the body 30), and preferably substantially coincides with the outer diameter. Therefore, the inner diameter of the inner space formed by the inner wall surface 95a is larger than the inner diameter of the inner space formed by the inner wall surface 93a. Further, the internal space defined by the inner wall surface 95 a communicates with the internal space defined by the upper peripheral wall portion 91 in the housing 99. However, the cylindrical portion 93 does not reach the internal space defined by the inner wall surface 95a.
　このように構成されるアダプタ９０は、射出液の移送の際には図５に示すように、アダプタ９０がサブ組立体１０Ａの上方に位置するように、サブ組立体１０Ａに対して取り付けられる。この取付状態について図５に基づいて説明する。アダプタ９０の取り付けに当たっては、好ましくはサブ組立体１０Ａの射出口３１ａが上方（鉛直方向）を向くように配置される。なお、射出口３１ａは必ずしも上方を向く必要はないが、後述するように射出液の移送時には収容部９９ａに射出液が収容された状態でロッド部４４の操作が行われるため、射出液が零れないようにするために射出口３１ａが可及的に上方を向くのが好ましい。また、アダプタ９０がサブ組立体１０Ａに取り付けられた直後においては、以降のロッド部４４の操作を考慮して、プランジャ４の頭部４１が、収容部３２の最奥に位置する端面に接触した状態とされる。 The adapter 90 configured as described above is attached to the sub-assembly 10A such that the adapter 90 is located above the sub-assembly 10A when transferring the injection liquid, as shown in FIG. This mounting state will be described with reference to FIG. When mounting the adapter 90, the sub-assembly 10A is preferably arranged such that the injection port 31a faces upward (vertically). Note that the injection port 31a does not necessarily need to face upward, but since the operation of the rod portion 44 is performed in a state where the injection liquid is stored in the storage portion 99a during the transfer of the injection liquid, as described later, the injection liquid is spilled. It is preferable that the injection port 31a faces upward as much as possible in order to prevent the occurrence. Immediately after the adapter 90 is attached to the sub-assembly 10A, the head 41 of the plunger 4 comes into contact with the end face located at the innermost part of the housing part 32 in consideration of the subsequent operation of the rod part 44. State.
　このようなサブ組立体１０Ａに対して、アダプタ９０の下側周壁部９５の内部空間に対してボディ３０の先端部が挿入され、下側周壁部９５の内壁面９５ａが、ボディ３０の中腹部と嵌め合った状態となり、且つ、筒状部９３の内壁面９３ａが、ボディ３０の柱状の先端部と嵌め合った状態となる。そして、これらの嵌め合い状態を維持しながら、突起部９２ｂの先端部がノズル部３１の先端面３１ｃに突き当たるまで、アダプタ９０に対するサブ組立体１０Ａの挿入が行われる。なお、図５に示す取付状態は、突起部９２ｂの先端部がノズル部３１の先端面３１ｃに突き当たった状態を示す。 The distal end of the body 30 is inserted into the internal space of the lower peripheral wall 95 of the adapter 90 in such a subassembly 10A, and the inner wall surface 95a of the lower peripheral wall 95 is , And the inner wall surface 93a of the cylindrical portion 93 is fitted with the columnar tip of the body 30. Then, while maintaining these fitted states, the sub-assembly 10A is inserted into the adapter 90 until the distal end of the protrusion 92b abuts against the distal end surface 31c of the nozzle 31. Note that the mounting state shown in FIG. 5 shows a state in which the distal end of the projection 92b abuts on the distal end surface 31c of the nozzle 31.
　この取付状態において、ノズル部３１の射出口３１ａと、充填ノズル９２の開口端９２ａとは重なった状態となる。そのため、収容部９９ａに収容された射出液が、開口端９２ａ及び射出口３１ａを介してサブ組立体１０Ａのノズル部３１側に流出可能な状態が形成されていることになる。なお、この状態においては開口端９２ａは射出口３１ａより大きいため、環状の突起部９２ｂは、射出口３１ａを塞ぐことなくそれを囲むように環状に先端面３１ｃに接触している。更に、上記の通り突起部９２ｂを含むハウジング９９は、好適な可撓性を発揮し得る樹脂材料によって形成されていることから、アダプタ９０を取り付けた際のユーザの操作により突起部９２ｂが先端面３１ｃに対して突き当てられたときに突起部９２ｂが好適に撓み、突起部９２ｂと先端面３１ｃとの間に良好な接触状態が形成される。これにより、突起部９２ｂと先端面３１ｃとの間に良好なシール性が生まれ、収容部９９ａに射出液を注入した際に、射出液が無駄に漏れ出すのを抑制できる。 に お い て In this mounting state, the injection port 31a of the nozzle portion 31 and the opening end 92a of the filling nozzle 92 overlap each other. Therefore, a state is established in which the injection liquid stored in the storage portion 99a can flow out to the nozzle portion 31 side of the sub-assembly 10A via the opening end 92a and the injection port 31a. In this state, since the opening end 92a is larger than the emission port 31a, the annular projection 92b is in annular contact with the distal end surface 31c so as to surround the emission port 31a without blocking it. Further, since the housing 99 including the protrusion 92b is formed of a resin material capable of exhibiting suitable flexibility as described above, the protrusion 92b is moved to the distal end surface by a user operation when the adapter 90 is attached. When the projection 92b is abutted against the projection 31c, the projection 92b is appropriately bent, and a good contact state is formed between the projection 92b and the distal end surface 31c. Thereby, a good sealing property is created between the protrusion 92b and the distal end surface 31c, and when the injection liquid is injected into the housing portion 99a, it is possible to suppress the injection liquid from leaking wastefully.
　このように図５に示す取付状態では、突起部９２ｂが先端面３１ｃに環状に接触した状態であり、且つ、筒状部９３と下側周壁部９５とによって、サブ組立体１０Ａに対してアダプタ９０が安定的に支持された状態となっている。そのため、安全な射出液の移送を実現することができる。 In this manner, in the mounting state shown in FIG. 5, the protrusion 92b is in a state of being in annular contact with the distal end face 31c, and the adapter is attached to the sub-assembly 10A by the cylindrical portion 93 and the lower peripheral wall 95. 90 is stably supported. Therefore, safe transfer of the injection liquid can be realized.
　実際の射出液の移送は、図６に示す流れに従って行われる。先ず、上記のアダプタ９０を準備する（Ｓ１０１の処理）。このとき、上述したように、サブ組立体１０Ａにおいて、プランジャ４の頭部４１が、収容部３２の最奥に位置する端面に接触した状態とされている。次いで上述したようにアダプタ９０を、注射器１を構成するサブ組立体１０Ａに取り付けて図５に示す取付状態を形成する（Ｓ１０２の処理）。そして、収容部９９ａが上方に位置する状態（図５に示す状態）で、収容部９９ａの開放端から移送すべき射出液を収容部９９ａ内に注入する。 The actual transfer of the injection liquid is performed according to the flow shown in FIG. First, the above-described adapter 90 is prepared (the process of S101). At this time, as described above, in the sub-assembly 10A, the head 41 of the plunger 4 is in a state of being in contact with the end face located at the innermost part of the housing portion 32. Next, as described above, the adapter 90 is attached to the sub-assembly 10A constituting the syringe 1 to form the attached state shown in FIG. 5 (processing of S102). Then, the injection liquid to be transferred from the open end of the storage unit 99a is injected into the storage unit 99a in a state where the storage unit 99a is positioned above (the state illustrated in FIG. 5).
　射出液の収容部９９ａの注入が終了すると、射出液が零れないように収容部９９ａが上方に位置する状態を維持しながら、ユーザによりロッド部４４が下方に引き下ろされる。このロッド部４４の動きによって、収容部９９ａ内の射出液が射出口３１ａを介して射出ノズル３１ｂに流れ込み、収容部３２へと至ることで移送が行われる。ここで、アダプタ９０において、収容部９９ａの一部領域Ｒ１と充填ノズル９２の内部の全空間に着目する。これらの空間（領域）は、アダプタ９０の内部において一部領域Ｒ１から開口端９２ａに至るまでの連続した空間となっており、当該空間は所定空間に相当する。そして、この連続した空間は、その内径が、アダプタ９０の上側から開口端９２ａに進むに従い縮径するように構成されている。 (4) When the injection of the injection liquid into the storage part 99a is completed, the rod part 44 is pulled down by the user while maintaining the state in which the storage part 99a is positioned so that the injection liquid does not spill. By the movement of the rod portion 44, the injection liquid in the storage portion 99a flows into the injection nozzle 31b via the injection port 31a, and reaches the storage portion 32 to be transferred. Here, in the adapter 90, attention is paid to the partial region R1 of the storage portion 99a and the entire space inside the filling nozzle 92. These spaces (regions) are continuous spaces from the partial region R1 to the opening end 92a inside the adapter 90, and the spaces correspond to predetermined spaces. The continuous space is configured such that its inner diameter decreases as it goes from the upper side of the adapter 90 to the open end 92a.
　このような構成では、アダプタ９０の内部空間において、その内壁面が中心軸Ｌ１に対して連続的に傾斜し内部空間が次第に狭くなっていく。ロッド部４４が下方に引き下ろされることで生じる吸引力が射出液に作用したときに、このような連続した傾斜面が存在することで、射出液が充填ノズル９２内において分散しにくく射出口３１ａに対して集約されやすくなる。特に、移送すべき射出液の量が少ない場合には、充填ノズル９２の内壁面から受ける抵抗力の影響が大きくなり、上記吸引力を射出液に効果的に作用させるのが難しくなるが、このように連続した傾斜面による射出液の集約構造（たとえて言えば、漏斗状の構造）が形成されることで、効率的な射出液の移送とともに、その移送の際に周囲に存在する空気と射出液とが混ざる程度を抑えながら移送を行うことが可能となる。なお、より好ましくは上記の通り、充填ノズル９２内の全空間に上記の連続した傾斜面が形成されるが、射出液と空気との混在を生じにくくさせる限りにおいて、充填ノズル９２の内部空間の一部に上記の連続した傾斜面以外の内壁面（例えば、中心軸Ｌ１に平行な内壁面）で画定される空間が含まれてもよい。 In such a configuration, in the internal space of the adapter 90, its inner wall surface is continuously inclined with respect to the central axis L1, and the internal space is gradually narrowed. When the suction force generated by pulling down the rod portion 44 on the injection liquid acts on the injection liquid, the injection liquid is less likely to be dispersed in the filling nozzle 92 due to the existence of such a continuous inclined surface. To be easily aggregated. In particular, when the amount of the injection liquid to be transferred is small, the influence of the resistance force received from the inner wall surface of the filling nozzle 92 increases, and it becomes difficult to effectively apply the suction force to the injection liquid. As described above, the integrated structure of the injection liquid by the continuous inclined surface (for example, a funnel-like structure) is formed, so that the injection liquid can be efficiently transferred, and at the same time, the air existing around the transfer can be removed. Transfer can be performed while suppressing the degree of mixing with the injection liquid. More preferably, as described above, the continuous inclined surface is formed in the entire space inside the filling nozzle 92. However, as long as the mixture of the injection liquid and the air is hardly generated, the internal space of the filling nozzle 92 is A space defined by an inner wall surface other than the continuous inclined surface (for example, an inner wall surface parallel to the central axis L1) may be partially included.
　また、上述したように、開口端９２ａは射出口３１ａより大きいことから、ロッド部４４が下方に引き下ろされたときに、充填ノズル９２内において射出液は比較的円滑に流れやすくなっている。更に、環状の突起部９２ｂは高いシール性で先端面３１ｃに接触していることから、ロッド部４４の移動に伴う吸引力を効果的に発生させることができ、この点からも射出液の移送が好適に行われ得る。 As described above, since the opening end 92a is larger than the injection port 31a, the injection liquid easily flows relatively smoothly in the filling nozzle 92 when the rod portion 44 is pulled down. Further, since the annular projection 92b is in contact with the distal end surface 31c with high sealing properties, suction force accompanying the movement of the rod 44 can be effectively generated. Can be suitably performed.
　ロッド部４４の操作により射出液の移送が完了すると、アダプタ９０がサブ組立体１０Ａから取り外され、図２Ａに示すように射出液が収容部３２に充填された状態となる。その後、そのサブ組立体１０Ａがサブ組立体１０Ｂと組み合わされて注射器ハウジング２に装着されることで、使用可能な状態の注射器１が準備できる。 When the transfer of the injection liquid is completed by the operation of the rod part 44, the adapter 90 is detached from the sub-assembly 10A, and the injection liquid is filled in the accommodation part 32 as shown in FIG. 2A. Thereafter, the sub-assembly 10A is combined with the sub-assembly 10B and mounted on the syringe housing 2, so that the syringe 1 in a usable state can be prepared.
　＜変形例１＞
　上記実施形態において、アダプタ９０の取付状態では、筒状部９３の内壁面９３ａが、柱状のノズル部３１の外周面と嵌め合った状態となることで、サブ組立体１０Ａに対するアダプタの取付状態を安定したものとしている。本変形例では、更に、ノズル部３１の外周面をその軸方向に沿って傾斜するテーパ面（例えば、図２Ａに示す状態において図の右側（シリンジ部３の基端側）に進むに従いノズル部３１の外径が大きくなるように形成されたテーパ面）としてもよい。このようにテーパ面を形成することで、アダプタ９０に対してサブ組立体１０Ａを挿入しやすくなるとともに、内壁面９３ａとテーパ面とが互いに押圧しながら嵌め合わされるため取付状態での結合力を増大でき、より安定的な取付状態を形成することができる。 <Modification 1>
In the above embodiment, when the adapter 90 is attached, the inner wall surface 93a of the cylindrical portion 93 is fitted with the outer peripheral surface of the columnar nozzle portion 31 to change the attachment state of the adapter to the sub-assembly 10A. It is stable. In this modification, the outer peripheral surface of the nozzle portion 31 is further tapered inclining along its axial direction (for example, in the state shown in FIG. 2A, the nozzle portion 31 moves to the right side (the base end side of the syringe portion 3) in the drawing). 31 may be a tapered surface formed so as to have a large outer diameter. By forming the tapered surface in this manner, the sub-assembly 10A can be easily inserted into the adapter 90, and the inner wall surface 93a and the tapered surface are fitted while being pressed against each other, so that the coupling force in the mounted state is reduced. It can be increased and a more stable mounting state can be formed.
　＜変形例２＞
　本変形例のアダプタ９０について、図７に基づいて説明する。図７に示すアダプタ９０では、アダプタ９０とサブ組立体１０Ａとの取付状態を保持する保持装置９６が設けられている。保持装置９６は、アダプタ９０側に設けられている第１部材９６ａと、サブ組立体１０Ａ側に設けられている第２部材９６ｂとからなり、両部材が機械的に連結等することで、アダプタ９０とサブ組立体１０Ａとの取付状態を保持するものである。保持装置９６としては、例えば、係合、解除が可能なスナップフィット機構が挙げられる。このような保持装置９６を採用することで、取付状態での結合力を増大でき、より安定的な取付状態を維持することができる。 <Modification 2>
An adapter 90 according to the present modification will be described with reference to FIG. In the adapter 90 shown in FIG. 7, a holding device 96 for holding the mounted state of the adapter 90 and the sub-assembly 10A is provided. The holding device 96 is composed of a first member 96a provided on the adapter 90 side and a second member 96b provided on the sub-assembly 10A side. The holding state between the sub-assembly 90 and the sub-assembly 10A is maintained. As the holding device 96, for example, a snap fit mechanism that can be engaged and released can be used. By employing such a holding device 96, the coupling force in the mounted state can be increased, and a more stable mounted state can be maintained.
１　　　　：注射器（無針注射器）
２　　　　：注射器ハウジング
３　　　　：シリンジ部
４　　　　：プランジャ
５　　　　：ピストン
１０　　　：装置組立体
１０Ａ　　：サブ組立体
１０Ｂ　　：サブ組立体
３０　　　：ボディ
３１　　　：ノズル部
３１ａ　　：射出口
３１ｂ　　：射出ノズル
３１ｃ　　：先端面
３２　　　：収容部
４４　　　：ロッド部
９０　　　：アダプタ
９１　　　：上側周壁部
９２　　　：充填ノズル
９２ａ　　：開口端
９２ｂ　　：突起部
９３　　　：筒状部
９３ａ　　：内壁面
９４　　　：鍔部
９５　　　：下側周壁部
９５ａ　　：内壁面
９６　　　：保持装置
９６ａ　　：第１部材
９６ｂ　　：第２部材
９９　　　：ハウジング
９９ａ　　：収容部
Ｒ１　　　：一部領域 1: Syringe (needle-free syringe)
2: Syringe housing 3: Syringe part 4: Plunger 5: Piston 10: Device assembly 10A: Subassembly 10B: Subassembly 30: Body 31: Nozzle part 31a: Injection port 31b: Injection nozzle 31c: Tip surface 32: Housing part 44: rod part 90: adapter 91: upper peripheral wall part 92: filling nozzle 92a: open end 92b: projection part 93: cylindrical part 93a: inner wall surface 94: flange part 95: lower peripheral wall part 95a: inner wall surface 96 : Holding device 96a: First member 96b: Second member 99: Housing 99a: Housing portion R1: Partial area

Claims (9)

  1. 　所定の射出液を射出ノズルから射出する射出装置に対して、該射出ノズルの射出口を介して該所定の射出液を移送するためのアダプタであって、
    　移送される前記所定の射出液を収容する収容部を画定するハウジングであって、前記射出装置に対して着脱可能に構成されたハウジングと、
    　前記ハウジングにおいて前記収容部に連通して設けられ、前記ハウジングが前記射出装置に取り付けられたときに前記射出ノズルの前記射出口が形成された該射出装置の端面に接触して該収容部に収容されている前記所定の射出液が該射出ノズル側に流出可能に形成された充填ノズルであって、該充填ノズルの開口端は、該収容部の内径より小さく該射出ノズルの射出口より大きく設定された充填ノズルと、
    　を備え、
    　前記収容部の一部領域から該充填ノズルの開口端に至るまでの前記ハウジングの内部空間のうち少なくとも該一部領域を含む連続した所定空間は、該充填ノズルの開口端側に進むに従い該所定空間の内径が縮径するように形成される、
    　アダプタ。     An adapter for transferring the predetermined injection liquid through an injection port of the injection nozzle to an injection device that outputs a predetermined injection liquid from an injection nozzle,
    A housing that defines a storage portion that stores the predetermined injection liquid to be transferred, and a housing configured to be detachable from the injection device,
    The housing is provided in communication with the housing portion, and when the housing is attached to the injection device, the housing comes into contact with an end surface of the injection device in which the injection port of the injection nozzle is formed and is housed in the housing portion. A filling nozzle formed so that the predetermined injection liquid can flow out to the injection nozzle side, wherein an opening end of the filling nozzle is set to be smaller than the inner diameter of the housing portion and larger than the injection port of the injection nozzle. Filling nozzle,
    With
    A continuous predetermined space including at least the partial region in the internal space of the housing from the partial region of the housing portion to the opening end of the filling nozzle is defined as the predetermined space proceeds toward the opening end side of the filling nozzle. Formed such that the inner diameter of the space is reduced,
    adapter.
  2. 　前記所定空間は、前記一部領域と前記充填ノズルの内部空間の全てを含む空間であって、
    　前記所定空間は、前記一部領域から前記充填ノズルの開口端まで該充填ノズルの開口端側に進むに従い、該所定空間の内径が連続して縮径するように形成される、
    　請求項１に記載のアダプタ。     The predetermined space is a space including all of the partial region and the internal space of the filling nozzle,
    The predetermined space is formed such that the inner diameter of the predetermined space is continuously reduced in diameter as the part proceeds from the partial region to the opening end of the filling nozzle toward the opening end of the filling nozzle.
    The adapter according to claim 1.
  3. 　前記充填ノズルは、該充填ノズルから前記アダプタの先端側に突出した環状の突起部であって、該ハウジングが前記射出装置に取り付けられたときに該突起部の先端が該射出装置の端面に当接するように形成された突起部を有する、
    　請求項１又は請求項２に記載のアダプタ。     The filling nozzle is an annular protrusion protruding from the filling nozzle toward the distal end of the adapter, and when the housing is attached to the injection device, the distal end of the projection contacts the end surface of the injection device. Having a protrusion formed to be in contact with the
    The adapter according to claim 1 or 2.
  4. 　前記突起部は、可撓性部材から形成される、
    　請求項３に記載のアダプタ。     The protrusion is formed from a flexible member,
    The adapter according to claim 3.
  5. 　前記射出装置は、前記射出ノズルを内部に有する柱状のノズル部であって、該射出ノズルの射出口がその端面に露出して形成されたノズル部を有し、
    　前記ハウジングは、該ハウジングにおいて前記充填ノズルを囲むように設けられ、且つ、該ハウジングが前記射出装置に取り付けられたときに前記ノズル部の外周壁面に対して嵌合した状態となる第１筒状部を有する、
    　請求項１から請求項４の何れか１項に記載のアダプタ。     The injection device has a columnar nozzle portion having the injection nozzle therein, and has a nozzle portion formed by exposing an injection port of the injection nozzle to an end surface thereof,
    The housing is provided so as to surround the filling nozzle in the housing, and is in a first cylindrical shape fitted to an outer peripheral wall surface of the nozzle portion when the housing is attached to the injection device. Having a part,
    The adapter according to any one of claims 1 to 4.
  6. 　前記ノズル部の前記外周壁面は、該ノズル部の軸方向に沿って傾斜するテーパ面を形成し、
    　前記ハウジングが前記装置本体に取り付けられたときに、前記第１筒状部の内壁面は前記ノズル部の前記外周壁面を押圧しながら前記嵌合した状態となる、
    　請求項５に記載のアダプタ。     The outer peripheral wall surface of the nozzle portion forms a tapered surface that is inclined along an axial direction of the nozzle portion,
    When the housing is attached to the apparatus main body, the inner wall surface of the first tubular portion is in the fitted state while pressing the outer peripheral wall surface of the nozzle portion.
    The adapter according to claim 5.
  7. 　前記ハウジングが前記射出装置に取り付けられたときに前記第１筒状部と前記ノズル部の前記外周壁面との嵌合した状態を保持する保持部を、更に備える、
    　請求項５又は請求項６に記載のアダプタ。     A holding unit that holds a state where the first cylindrical portion and the outer peripheral wall surface of the nozzle unit are fitted when the housing is attached to the injection device;
    An adapter according to claim 5 or claim 6.
  8. 　前記ハウジングは、該ハウジングにおいて前記第１筒状部を囲むように設けられ、且つ、該ハウジングが前記射出装置に取り付けられたときに該射出装置の外周壁面に対して嵌合した状態となる第２筒状部を有する、
    　請求項５から請求項７の何れか１項に記載のアダプタ。     The housing is provided so as to surround the first tubular portion in the housing, and is in a state of being fitted to an outer peripheral wall surface of the injection device when the housing is attached to the injection device. Having two cylindrical portions,
    The adapter according to any one of claims 5 to 7.
  9. 　所定の射出液を射出ノズルから射出する射出装置に対して、該射出ノズルの射出口を介して該所定の射出液を移送するためのアダプタであって、移送される該所定の射出液を収容する収容部を画定するハウジングと、前記ハウジングにおいて前記収容部に接続して設けられ、その開口端は該収容部の内径より小さく該射出ノズルの射出口より大きく設定された充填ノズルとを備え、該充填ノズルが接続された該収容部の一部領域から該充填ノズルの開口端に至るまでの該ハウジングの内部空間のうち少なくとも該一部領域を含む連続した所定空間は、該充填ノズルの開口端側に進むに従い該所定空間の内径が縮径するように形成されたアダプタを準備し、
    　前記射出装置に対して前記ハウジングを取り付けて、前記射出ノズルの前記射出口が形成された該射出装置の端面に前記充填ノズルの先端を接触させ、
    　前記収容部に、前記所定の射出液を注入し、
    　前記アダプタが前記射出装置の鉛直方向において上方に位置した状態で、前記収容部から前記所定の射出液を移し、該射出装置に対して移送する、
    　射出液の移送方法。     An adapter for transferring the predetermined injection liquid through an injection port of the injection nozzle to an injection device that discharges the predetermined injection liquid from the injection nozzle, the adapter containing the predetermined injection liquid to be transferred. A housing defining an accommodating portion to be provided, and a filling nozzle provided at the housing so as to be connected to the accommodating portion and having an open end smaller than the inner diameter of the accommodating portion and larger than the injection port of the injection nozzle; A continuous predetermined space including at least the partial region in the internal space of the housing from a partial region of the housing portion to which the charging nozzle is connected to an opening end of the charging nozzle is formed by an opening of the charging nozzle. Prepare an adapter formed so that the inner diameter of the predetermined space is reduced as it proceeds to the end side,
    Attach the housing to the injection device, contact the tip of the filling nozzle to the end surface of the injection device in which the injection port of the injection nozzle is formed,
    Inject the predetermined injection liquid into the container,
    In a state where the adapter is located above the injection device in the vertical direction, the predetermined injection liquid is transferred from the storage section, and transferred to the injection device.
    How to transfer the injection liquid.
PCT/JP2019/039195 2018-10-04 2019-10-03 Adapter and injection fluid transport method WO2020071506A1 (en)

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US20220000717A1 (en) 2022-01-06
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EP3868353A4 (en) 2022-08-24
US11992460B2 (en) 2024-05-28
JP7148627B2 (en) 2022-10-05
CN112804981A (en) 2021-05-14
EP3868353A1 (en) 2021-08-25

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