WO2020062154A1 - 检测科研用动物行为的方法和*** - Google Patents
检测科研用动物行为的方法和*** Download PDFInfo
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- WO2020062154A1 WO2020062154A1 PCT/CN2018/108698 CN2018108698W WO2020062154A1 WO 2020062154 A1 WO2020062154 A1 WO 2020062154A1 CN 2018108698 W CN2018108698 W CN 2018108698W WO 2020062154 A1 WO2020062154 A1 WO 2020062154A1
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- behavior
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- 241001465754 Metazoa Species 0.000 title claims abstract description 141
- 238000011160 research Methods 0.000 title claims abstract description 108
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- 238000001514 detection method Methods 0.000 claims abstract description 95
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K29/00—Other apparatus for animal husbandry
Definitions
- the present application belongs to the field of scientific research equipment manufacturing, and particularly relates to a method and system for detecting behaviors of scientific research animals.
- AD Alzheimer Disease
- a degenerative disease of the central nervous system The onset is hidden and the course of disease is chronically progressive.
- the main clinical manifestations are memory impairment, cognition Comprehensive dementia such as dysfunction, language disorder, behavior and personality change, seriously affects the patient's social, occupation and life, the cause is temporarily unknown.
- AD is the sixth leading cause of death in the United States (3.6% of all causes of death).
- AD Alzheimer's disease
- the diagnosis of AD usually comes from the detection of neuropathological changes in the brain of the patient after death.
- the analysis of clinical results and pathological characteristics that is, the correlation between clinical pathology, has suggested the relationship between pathological processes and cognitive status.
- preclinical animal models especially mouse models, are widely used to detect the pathophysiology of AD and predict the effect of drug intervention on AD. Because no one zoology model can fully reproduce all the characteristics of human AD, it is necessary to use multiple zoology models for research.
- AD mouse models There are currently no less than 11 AD mouse models commonly used (ie PDAPP, TG2576, APP23, TgCRND8, J20, APP / PS1, TG2576 + PS1 (M146L), APP / PS1 KI, 5 ⁇ FAD, 3 ⁇ Tg-AD and Tg4-42); people use multiple behavioral paradigms to assess cognitive impairment in mouse models, including spatial memory testing (Morris water maze, eight-arm water maze, and Barnes maze), joint learning paradigm (passive Avoidance and fear conditioning), selection tasks (Y maze and T maze), new object recognition, attention paradigm (3 or 5 selection sequence response test), task switching, and reverse learning.
- spatial memory testing Meris water maze, eight-arm water maze, and Barnes maze
- joint learning paradigm Passive Avoidance and fear conditioning
- selection tasks Y maze and T maze
- new object recognition attention paradigm (3 or 5 selection sequence response test)
- attention paradigm 3 or 5 selection sequence response test
- a behavior detection system for scientific research animals detects animals' behaviors by mounting sensors on the animals, which mainly uses motion sensors to collect the motion data of the animals to be detected in real time; according to the collected motion data, analyzes the motion of the animals to be detected Vector direction and action trend; when it is analyzed that the continuous and consistent action trend of the animal to be detected reaches a preset number of times and the corresponding motion vector direction is consistent, it is confirmed that there is a periodic action trend; the characteristic data of the periodic action trend and the preset The characteristic data of the movement trend is compared to obtain the matching degree between the periodic movement trend and the preset movement trend; if the matching degree is within a preset threshold range, the continuous action generated by the animal to be detected during the duration of the periodic movement trend The number of actions is counted, and the continuous action behavior is a continuous movement trend.
- the above-mentioned method or system for detecting animal behaviors by mounting sensors on the animals requires the installation of specific sensors on these small animals. This process often causes discomfort to the animals, which affects the behavior of the animals and reduces the collection. Reliability of behavioral data, and the sensor is at risk of being damaged by experimental animals. To reduce this risk, higher requirements are placed on the installation of the sensor (for example, implanted under the skin of an animal).
- sensors are generally powered by batteries, and the batteries need to be replaced or recharged after a period of time. Therefore, the time for a single recording of animal behavior will be limited.
- the purpose of this application is to provide a method and system for detecting the behavior of scientific research animals, so as to detect the behavior of scientific research animals at low cost without interfering with the behavior of scientific research animals.
- the first aspect of the present application provides a method for detecting the behavior of an animal for scientific research, which is applied to a system including a detection frame, a computing device, and a cabinet.
- the method includes:
- the wireless signal transceiver deployed on the detection frame detects the position information of the scientific animal in the detection frame in the detection frame by transmitting and receiving wireless signals, and transmits the position information to the computing device.
- the detection frame Fixed in the box;
- the computing device displays position information of the scientific research animal in the detection frame
- the computing device evaluates the behavior of the scientific research animal according to the position information of the scientific research animal within the detection frame.
- a second aspect of the present application provides a system for detecting the behavior of animals for scientific research.
- the system includes a detection frame, a computing device, and a case.
- the detection frame is fixed in the case, and a wireless signal transceiver is disposed on the detection frame.
- the computing device includes a display module and an evaluation module;
- the detection frame is used by the wireless signal transceiver to detect the position information of the scientific research animal in the detection frame in the detection frame by transmitting and receiving wireless signals and transmitting the position information to the computing device;
- the display module is configured to display position information of the scientific research animal in the detection frame
- the evaluation module is configured to evaluate the behavior of the scientific research animal according to the position information of the scientific research animal in the detection frame.
- the wireless signal transceiver detects the position information of the scientific animal in the detection frame by transmitting and receiving the wireless signal, it does not need to implant the sensor device as in the prior art. Under the skin of the animal, therefore, the technical solution provided in this application does not interfere with the behavior of the animal itself, and therefore does not interfere with the detection of the behavior of the animal; on the other hand, the wireless signal transceiver deployed on the detection frame may be an existing The commonly used components have low cost. Therefore, the technical solution provided by this application is low in cost when detecting the behavior of scientific research animals, which can greatly save scientific research funds.
- FIG. 1 is a schematic diagram of an implementation process of a method for detecting an animal behavior for scientific research according to an embodiment of the present application
- FIG. 2 is a schematic diagram of a detection frame and a box in a system for detecting animal behavior for scientific research according to an embodiment of the present application;
- FIG. 3 is a schematic structural diagram of a system for detecting animal behaviors for scientific research according to an embodiment of the present application.
- FIG. 4 is a schematic structural diagram of a system for detecting behaviors of scientific research animals according to another embodiment of the present application.
- FIG. 5-a is a schematic structural diagram of a system for detecting an animal behavior for scientific research according to another embodiment of the present application.
- FIG. 5-b is a schematic structural diagram of a system for detecting an animal behavior for scientific research according to another embodiment of the present application.
- FIG. 1 is a schematic flowchart of an implementation of a method for detecting animal behavior for scientific research according to an embodiment of the present application. The method is applied to a system including a detection frame, a computing device, and a cabinet. The method illustrated in FIG. 1 mainly includes the following steps S101 to S103, which are described in detail as follows:
- the wireless signal transceiver deployed on the detection frame detects and transmits the position information of the scientific animal in the detection frame to the computing device by transmitting and receiving the wireless signal, and the position information is fixed to the cabinet.
- the wireless signal transceiver may be an infrared detector, a radar, or a sound wave detector.
- the wireless signal may be an infrared light, a radar wave, or a sound wave, that is, the wireless signal sent by the infrared detector is infrared, radar. Radar waves are emitted, sound waves are emitted by sound wave detectors, and animals for scientific research can be mice, rats, etc. used in scientific research tasks (eg, establishing preclinical animal models, etc.) mentioned in the background of this application.
- step S101 uses the wireless signal transceiver as an infrared detector as an example to explain the technical solution of step S101 as follows:
- the detection frame is composed of an infrared detector that is an infrared detector mounted on the outer frame and an infrared reception sensing element (for convenience of description, this type of detection frame is hereinafter referred to as an infrared touch detection frame)
- an infrared touch detection frame these infrared detectors form a horizontal and vertical infrared detection network in the infrared touch detection frame when receiving and transmitting infrared rays.
- an animal for scientific research for example, a mouse
- enters the infrared detection network and blocks infrared reception somewhere the intensity of the infrared rays received by the infrared receiving and sensing elements at this point and the vertical direction will change.
- the infrared touch detection frame can interpolate the data of each point, which can reach a resolution of 4096 ⁇ 4096; at any moment when the infrared touch detection frame works, there is only a pair of infrared emitting sensations.
- the measuring element and the infrared receiving sensing element (referring to an infrared emitting sensing element and an infrared receiving sensing element corresponding to the physical location) are responding, and the circuit realizes rapid response by collecting high-frequency data from the infrared detector. (Response speed ⁇ 15ms).
- the infrared touch detection frame can use a conventional infrared touch screen on the market (without glass), and the size ranges from 15 inches to 300 inches, and can also be customized according to needs.
- the infrared touch detection frame is connected to a computing device, such as a personal computer, a smart phone, etc., via a USB interface.
- a computing device such as a personal computer, a smart phone, etc.
- the real-time position coordinates of the scientific research animal measured by the aforementioned method are transmitted to the computing device.
- Any touch-enabled operating system can directly process the real-time position coordinates.
- information such as real-time position coordinates and response time is stored in the data of the TOUCHINUPT structure and can be called directly through interface commands provided by Windows.
- the computing device displays position information of the scientific research animal in the detection frame.
- the control software in the computing device can not only display the position information of the scientific research animal in the detection frame to the user, but also The position information in the detection frame is used to draw real-time trajectories of scientific research animals. These real-time trajectories can also be displayed to the user through the user interface of the control software.
- the computing device evaluates the behavior of the scientific research animal according to the position information of the scientific research animal in the detection frame.
- control software in the computing device may calculate the direction and / or rate of movement of the scientific research animal and / or the projection size of the x-axis and y-axis directions according to the position information of the scientific research animal in the detection frame, and according to the calculated scientific research application,
- the direction and / or rate of animal movement and / or the projection size of the x-axis and y-axis directions and a set threshold determine the behavior of animals for scientific research. For example, according to the calculated direction and / or rate of movement of scientific animals, if these directions and / or rates are greater than a set direction and / or rate threshold, it indicates that the scientific animals are in motion. Further, if this The duration of the exercise is greater than a set time threshold, which indicates that the scientific animal is very active, has a strong vitality, and so on.
- the computing device may also trigger the behavioral stimulation device to send a stimulus signal to the scientific research animal according to the preset conditions and the evaluated behavior of the scientific research animal, wherein the behavioral stimulation device includes a device capable of emitting Electronic devices with light, electrical or sound signals, such as speakers, lasers, video players, foot shockers, etc., may also include devices that emit mechanical stimulation signals, such as high-power electric fans and so on.
- the control software of the computing device triggers the behavioral stimulation device to send a stimulus signal to the scientific animal, such as sound, strong light, and so on.
- the detection frame is fixed in the box, which provides and limits the range of activities of the scientific research animal.
- the inner wall of the box is preferably flush with the inner wall of the detection frame, that is, the detection frame is embedded in the box, and in the entire system, there must be no objects other than scientific research animals.
- the detection frame forms an occlusion.
- the wireless signal transceivers deployed on the detection frame for example, the infrared emission sensing element-infrared receiving sensing element, should be as far as possible from the bottom of the box to the height of the scientific research animal on the back and ventral sides. The midpoint is flush.
- the height of the wireless signal transceiver from the bottom plate of the cabinet can be designed as 15mm, as shown in FIG. 2.
- These deployed wireless signal transceivers send and receive the three-dimensional position information of the scientific research animals in the wireless signal detection box in the detection frame, and the projection size in the x-axis, y-axis, and z-axis directions.
- the infrared touch detection frame is used to directly detect the behavior of animals for scientific research, and the cost is low.
- the process of locating these scientific animals in real time through the infrared touch detection frame is very fast, can reach 60Hz, and the detection accuracy is high, which can reach 4096 ⁇ 4096.
- the infrared touch detection frame is driven by a standard touch screen, so it directly passes the USB interface
- a computing device such as a personal computer can report the position of the animal for scientific research to the computing device, which is very convenient to install and use.
- the control software of the computing device can directly read the position of scientific research animals without additional calculation process, it can control other hardware (such as display screen, speaker, laser, etc.) to stimulate these scientific research animals in real time.
- the wireless signal transceiver detects the position information of the scientific animals in the detection frame by receiving and transmitting wireless signals, it does not need to be as existing
- the sensor device is implanted under the skin of the animal. Therefore, the technical solution provided in this application will not interfere with the behavior of the animal itself, and therefore will not interfere with the detection of the behavior of the animal.
- the signal transceiver can be an existing relatively commonly used component, and the cost itself is not high. Therefore, the technical solution provided by the present application is low in cost when detecting the behavior of scientific research animals, and can greatly save scientific research funds.
- FIG. 3 is a schematic diagram of a system for detecting animal behavior for scientific research according to an embodiment of the present application. For ease of explanation, only necessary parts of the device are shown.
- the device illustrated in FIG. 3 mainly includes a detection frame 302, a computing device 301, and a box 303.
- the detection frame 302 is fixed in the box 303.
- a wireless signal transceiver is disposed on the detection frame 302.
- the computing device 301 includes a display module 304 and an evaluation module 305. As detailed below:
- a detection frame 302 is configured for the wireless signal transceiver to detect the position information of the scientific research animal in the detection frame 302 by transmitting and receiving the wireless signal and transmit the position information to the computing device 301.
- a display module 304 configured to display position information of the scientific research animal in the detection frame 302;
- the evaluation module 305 is configured to evaluate the behavior of the scientific research animal according to the position information of the scientific research animal within the detection frame 302.
- the evaluation module 305 illustrated in FIG. 3 may include a calculation unit 401 and a behavior determination unit 402, such as a system for detecting animal behaviors for scientific research as illustrated in FIG. 4, wherein:
- a calculation unit 401 configured to calculate the direction and / or rate of movement of the scientific research animal and / or the projection size of the x-axis and y-axis directions according to the position information of the scientific research animal within the detection frame 302;
- the behavior determining unit 402 is configured to determine the behavior of the scientific research animal according to the direction and / or rate of movement of the scientific research animal and / or the projection size of the x-axis and y-axis directions and the set threshold.
- the above-mentioned system for detecting animal behaviors for scientific research illustrated in FIG. 3 or 4 may further include a behavior stimulation device 502, and the computing device 301 may further include a trigger module 501, as shown in FIG. 5-a or FIG. 5-b.
- the triggering module 501 is configured to trigger a behavioral stimulation device 502 to send a stimulus signal to a research animal according to a preset condition and the behavior of the research animal.
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Abstract
Description
Claims (10)
- 一种检测科研用动物行为的方法,应用于包括检测框、计算设备和箱体的***,其特征在于,所述方法包括:所述检测框上部署的无线信号收发器通过收发无线信号检测所述检测框内科研用动物在所述检测框内的位置信息并将所述位置信息传输至所述计算设备,所述检测框固定于所述箱体内;所述计算设备显示所述科研用动物在所述检测框内的位置信息;所述计算设备根据所述科研用动物在所述检测框内的位置信息评估所述科研用动物的行为。
- 如权利要求1所述的检测科研用动物行为的方法,其特征在于,所述计算设备根据所述科研用动物在所述检测框内的位置信息评估所述科研用动物的行为,包括:根据所述科研用动物在所述检测框内的位置信息计算所述科研用动物运动的方向和/或速率和/或x轴和y轴方向投影大小;根据所述科研用动物运动的方向和/或速率和/或x轴和y轴方向投影大小以及设定的阈值,确定所述科研用动物的行为。
- 如权利要求1或2所述的检测科研用动物行为的方法,其特征在于,所述方法还包括:所述计算设备根据预设条件和所述评估出来的科研用动物的行为,触发行为刺激设备对所述科研用动物发出刺激信号。
- 如权利要求3所述的检测科研用动物行为的方法,其特征在于,所述行为刺激设备包括能够发出光、电或声音信号的电子设备。
- 如权利要求1或2所述的检测科研用动物行为的方法,其特征在于,所述方法还包括:所述计算设备根据所述科研用动物在所述检测框内的位置信息,绘制所述科研用动物的实时轨迹。
- 如权利要求1至5任意一项所述的检测科研用动物行为的方法,其特征在于,所述无线信号收发器为红外探测器、雷达或声波探测器,所述无线信号包括红外线、雷达波或声波。
- 一种检测科研用动物行为的***,其特征在于,所述***包括检测框、计算设备和箱体,所述检测框固定于所述箱体内,所述检测框上部署无线信号收发器,所述计算设备包括显示模块和评估模块;所述检测框,用于所述无线信号收发器通过收发无线信号检测所述检测框内科研用动物在所述检测框内的位置信息并将所述位置信息传输至所述计算设备;所述显示模块,用于显示所述科研用动物在所述检测框内的位置信息;所述评估模块,用于根据所述科研用动物在所述检测框内的位置信息评估所述科研用动物的行为。
- 如权利要求7所述的检测科研用动物行为的***,其特征在于,所述评估模块包括:计算单元,用于根据所述科研用动物在所述检测框内的位置信息计算所述科研用动物运动的方向和/或速率和/或x轴和y轴方向投影大小;行为确定单元,用于根据所述科研用动物运动的方向和/或速率和/或x轴和y轴方向投影大小以及设定的阈值,确定所述科研用动物的行为。
- 如权利要求7或8所述的检测科研用动物行为的***,其特征在于,所述***还包括行为刺激设备,所述计算设备还包括:触发模块,用于根据预设条件和所述评估出来的科研用动物的行为,触发所述行为刺激设备对所述科研用动物发出刺激信号。
- 如权利要求9所述的检测科研用动物行为的***,其特征在于,所述行为刺激设备包括能够发出光、电或声音信号的电子设备。
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CN101222842A (zh) * | 2005-05-24 | 2008-07-16 | 联邦科学和工业研究组织 | 动物管理*** |
WO2015120495A1 (de) * | 2014-02-14 | 2015-08-20 | Mkw Electronics Gmbh | Verfahren für die ortung von tieren |
CN105759238A (zh) * | 2016-04-19 | 2016-07-13 | 福州市佳璞电子商务有限公司 | 基于rfid定位的智能养殖舍 |
CN106614071A (zh) * | 2016-09-28 | 2017-05-10 | 南京农业大学 | 一种母猪产前行为监测***以及方法 |
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Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101222842A (zh) * | 2005-05-24 | 2008-07-16 | 联邦科学和工业研究组织 | 动物管理*** |
WO2015120495A1 (de) * | 2014-02-14 | 2015-08-20 | Mkw Electronics Gmbh | Verfahren für die ortung von tieren |
CN105759238A (zh) * | 2016-04-19 | 2016-07-13 | 福州市佳璞电子商务有限公司 | 基于rfid定位的智能养殖舍 |
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