WO2020059283A1 - Cuticle remover, method for producing same, use thereof - Google Patents

Cuticle remover, method for producing same, use thereof Download PDF

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Publication number
WO2020059283A1
WO2020059283A1 PCT/JP2019/028563 JP2019028563W WO2020059283A1 WO 2020059283 A1 WO2020059283 A1 WO 2020059283A1 JP 2019028563 W JP2019028563 W JP 2019028563W WO 2020059283 A1 WO2020059283 A1 WO 2020059283A1
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bioactive glass
cuticle
weight
keratin
extract
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PCT/JP2019/028563
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French (fr)
Japanese (ja)
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哲 許
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株式会社コンフェスタ
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/25—Silicon; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q3/00—Manicure or pedicure preparations

Definitions

  • the present invention relates to a cuticle remover capable of effectively softening the cuticle of the nail and the keratin of the skin, and a method for producing and using the same.
  • Cuticle is a tissue that protects the parts that make up the nails.However, if it is more than necessary, it will remove the water required for the nails, impair the beauty of the nails and fingertips, and prevent the application of beautiful nails Clearly, the cuticle is removed and the nail is pushed up to the base of the nail to cleanly apply the nail material, and a cuticle remover is used at that time.
  • the cuticle remover is a liquid or creamy composition that softens the cuticle in a short period of time and facilitates removal of cuticle and pushing up to the base of the nail.
  • the soles and heels are places where pressure and friction are applied to support weight, and old skin tends to accumulate. For this reason, it is necessary to periodically remove the keratin, and if the keratin is not neglected, not only the aesthetic appearance of the soles and heels may be impaired, but also the skin surface may dry and cause rough skin.
  • a liquid, creamy, or sheet-like keratin softener is used, and an operation of removing softened keratin with a file (file) is performed.
  • Patent Document 1 discloses a nail care composition having a cuticle removal effect. Specifically, it is a nail care composition characterized by containing an alkali agent, an amino acid, and a water-soluble polymer.
  • the alkali agent include sodium hydroxide, potassium hydroxide, sodium carbonate, potassium carbonate, and sodium hydrogen carbonate.
  • inorganic alkali agents such as potassium bicarbonate.
  • the alkali material has excellent skin cutoff and emollient effects, but has skin irritation and corrosiveness.
  • Patent Document 2 discloses a cuticle remover that removes cuticle and maintains a high pH for a long period of time. Specifically, it is a cuticle remover containing POE / POP alkyl ether and an alkali metal carbonate and having a pH of 10 or more. It is possible to reduce skin irritation and corrosiveness by using an alkali metal carbonate, but there is a problem that the cuticle removal and emollient effects are reduced.
  • bioactive materials in the medical field because of their ability to act on body fluids and tissues without impairing human health.
  • the main raw materials of bioactive materials are ceramics, glass, glass ceramics, and mixtures thereof (composite materials).
  • bioactive glass is one of the important categories of bioactive materials, and promotes natural healing by interacting with body fluids and tissues without affecting the health and tissues of the living body.
  • Bioactive glass is composed of silicon, calcium, sodium, and phosphorus, is widely used in the field of orthopedics, and is also applied to the dental and cosmetic industries, and is sold in the form of powder and nano powder. Have been.
  • An object of the present invention is to provide a keratin softening composition that has more effective cuticle removal and emollient performance in the care of the hairline, fingertips, and soles of nails, and has reduced skin irritation and corrosivity.
  • the cuticle remover of the present invention is obtained by removing the bioactive glass from the bioactive glass-containing liquid containing 2% to 50% by weight of the bioactive glass and 98% to 50% by weight of the aqueous solvent. It contains a bioactive glass extract, and the content of the bioactive glass extract is 30% by weight or more based on 100% by weight of the cuticle remover, and the pH is 8 or more and 10 or less.
  • the cuticle remover of the present invention preferably further contains a humectant and a thickener.
  • the method for producing a cuticle remover comprises mixing 2% to 50% by weight of bioactive glass in 98% to 50% by weight of an aqueous solvent for 1 minute to 100,000 hours. Then, a bioactive glass, and an extraction step of producing a keratin softening precursor composition including an extract from the bioactive glass, and filtering the keratin softening precursor composition to remove the bioactive glass, pH A filtration step of producing a cuticle remover made of the extract by adjusting the extractor to 8 or more and 10 or less, wherein the content of the extract is 30% by weight or more based on 100% by weight of the cuticle remover.
  • the method of using the cuticle remover according to the present invention includes a step of applying the cuticle remover of the present invention to cuticle and the skin around the cuticle at room temperature, and removing cuticle or pushing up to the base of the nail after being left for 30 seconds or more.
  • the cuticle remover of the present invention softens the cuticle generated at the base of the nails of the fingers and toes, helps to remove or push up to the base of the nails, and keratinizes around the nails of the fingers and toes, heels and soles. It is a cosmetic that helps soften and remove irritated skin.
  • BRIEF DESCRIPTION OF THE DRAWINGS It is the figure which compared the state of the keratin around the nail
  • BRIEF DESCRIPTION OF THE DRAWINGS It is the figure which compared the state of the keratin near the sole (heel) of (a) before use and (b) after use of the keratin softening composition concerning one Embodiment of this invention.
  • the keratin softening composition of the present invention softens the cuticle generated at the base of the finger and toe nails, and helps to remove or push up to the base of the nail, and also around the nails of the finger and toe, the heel and the sole. Is a cosmetic that helps soften and remove keratinized skin.
  • the keratin softening composition of the present invention is characterized by containing an extract from bioactive glass.
  • the keratin softening composition of the present invention may further include a humectant and a thickener.
  • Bioactive glass extract The bioactive glass extract is obtained by removing the bioactive glass from a bioactive glass-containing liquid containing 2% to 50% by weight of the bioactive glass and 98% to 50% by weight of the aqueous solvent.
  • the bioactive glass in the present invention is a powdery glass material containing silicon dioxide, sodium oxide, calcium oxide, and phosphorus pentoxide.
  • the bioactive glass is activated by moisture and releases ions of the components with high bioavailability (extracts from the bioactive glass), especially sodium ions and calcium in the keratin softening composition of the present invention.
  • the ions are effective for the keratin softening effect.
  • the bioactive glass is not particularly limited as long as it is a glass having a disintegrating property for gradually releasing alkali ions, and examples thereof include fluoroaluminosilicate glass used for dental materials, Vitryxx manufactured by SCHOTT, and the like.
  • the average particle size of the bioactive glass is not particularly limited, but may be, for example, 2.0 ⁇ m, 3.0 ⁇ m, 5.0 ⁇ m, 8.0 ⁇ m, 10.0 ⁇ m, 15.0 ⁇ m, or any of these numerical values. It may be a range.
  • the average particle diameter of the bioactive glass is preferably 15.0 ⁇ m or less, and more preferably 10.0 ⁇ m or less, since the active ingredient as a cuticle remover contained in the bioactive glass is easily extracted into an aqueous solvent. Is more preferably, 8.0 ⁇ m or less, further preferably, 5.0 ⁇ m or less.
  • the average particle size of the bioactive glass is preferably 0.5 ⁇ m or more, and more preferably 1.0 ⁇ m or more, from the viewpoint of the workability of the extraction step and the filtration step, which is the production process of the cuticle remover. Is more preferred.
  • the extract from the bioactive glass in the present invention is intended to mean, as an example, a solution produced by mixing the bioactive glass in a suitable solvent (such as water or a tris buffer) for a suitable time. And the solution is then filtered to a bioactive glass extract.
  • a suitable solvent such as water or a tris buffer
  • the aqueous solvent is not particularly limited as long as it is a liquid that can extract the active ingredient contained in the bioactive glass as a cuticle remover without impairing the function as the active ingredient.
  • This is a general concept including both a miscible solvent, an aqueous solution of a water-soluble component, and a mixed solvent of two or more of these.
  • Water includes all forms of liquid at room temperature, such as purified water, ion-exchanged water, and tap water.
  • Water-miscible solvents include, for example, C1-4 alcohols such as methanol, ethanol, n-propanol, isopropanol, n-butanol, s-butanol, isobutanol, t-butanol; ketone solvents such as acetone; dimethylformamide and dimethyl Amide solvents such as acetamide; sulfoxide solvents such as dimethyl sulfoxide; nitrile solvents such as acetonitrile; organic acid solvents such as acetic acid.
  • the water-miscible solvent is preferably ethanol or isopropanol, and more preferably ethanol.
  • the water-soluble component can be used without any particular limitation as long as it does not impair the effects of the present invention.
  • powders, humectants, thickeners, and preservatives that are usually blended in cosmetics, quasi-drugs, etc.
  • additives such as agents.
  • Other examples of the aqueous solution of the water-soluble component include a tris buffer.
  • the ratio between the bioactive glass and the aqueous solvent contained in the bioactive glass-containing liquid is not particularly limited as long as the bioactive glass extract can effectively exhibit the function as a cuticle remover.
  • the content of the bioactive glass is preferably 2% by weight or more based on 100% by weight of the bioactive glass-containing liquid in order to effectively extract the active ingredient contained in the bioactive glass.
  • the content of the aqueous solvent is preferably 98% by weight or less based on 100% by weight of the bioactive glass-containing liquid.
  • the content of the bioactive glass is 100% by weight. Is preferably 50% by weight or less, more preferably 40% by weight or less, still more preferably 30% by weight or less, still more preferably 20% by weight or less, and more preferably 10% by weight. It is particularly preferred that:
  • the content of the aqueous solvent is preferably 50% by weight or more, more preferably 60% by weight or more, and preferably 70% by weight or more based on 100% by weight of the bioactive glass-containing liquid. More preferably, it is even more preferably 80% by weight or more, and particularly preferably 90% by weight or more.
  • the content of the bioactive glass extract is 30% by weight or more, preferably 40% by weight or more, more preferably 50% by weight or more based on 100% by weight of the cuticle remover. preferable.
  • the pH of the keratin softening composition of the present invention is not particularly limited as long as it can exert a keratin softening action, and may be, for example, 7, 8, 9, 10, 11, 12, or the like, and may be in any range of these numerical values. May be. Specifically, the pH is more preferably 8 or more, further preferably 8.5 or more, even more preferably 9 or more, and particularly preferably 9.5 or more.
  • the pH of the keratin softening composition of the present invention is preferably weakly alkaline, preferably 11 or less, more preferably 10.5 or less, Particularly preferred is 10 or less.
  • the pH of 8 or more and 11 or less is equivalent to the pH of soap water or alkaline hot spring of daily necessities. These do not usually have a keratin softening effect at room temperature and for a short time, but the keratin softening composition of the present invention contains an alkali ion component (mineral component) that enhances the effect of penetrating into the keratin, so However, it can exhibit a keratin softening effect.
  • an alkali ion component mineral component
  • Conventional keratin softeners are mainly alkaline and have a pH of greater than 11. While these keratin softeners exhibit a high keratin softening effect, there is a problem that the skin is highly irritating and corrosive, causing damage to the skin.
  • the keratin softener of the present invention exerts a high keratin softening effect even when the pH is suppressed to a weak alkalinity, so that both a high keratin softening effect and reduction of damage to the skin can be achieved. is there.
  • the keratin softening composition (cuticle remover is one aspect thereof) described in the present embodiment may contain other components as long as the effects of the present invention are not impaired.
  • Other components include a thickener, a humectant / humectant, an organic solvent, a preservative, a surfactant, a fragrance, an oil, a colorant, and the like. Thickeners, organic solvents, and the like are used to impart appropriate viscosity and volatility.
  • a thickener is an additive used to increase the viscosity of the keratin softening composition to make it into a gel or cream.
  • the thickener include “Aristoflex HMB” by Clariant Japan, a synthetic polymer represented by carboxyvinyl polymer, a natural polymer represented by pectin and xanthan gum, fine particle silica, bentonite, and hectonite.
  • a humectant / humectant is an additive used for moisturizing an affected area from which keratin has been removed after removing keratin using a keratin softening composition.
  • the humectant / humectant include polyethylene glycol 600 (abbreviation: PEG600), glycerin, amino acids, pyrrolidone carboxylic acid, lactic acid, hyaluronic acid, mucopolysaccharides such as chondroitin sulfate, glycerin, propylene glycol, butylene glycol, sorbit and the like. And the like polyhydric alcohols.
  • the method for producing a keratin softening composition of the present invention comprises mixing a bioactive glass in water for 1 minute to 100000 hours to form a keratin softening precursor containing the bioactive glass, an extract from the bioactive glass, and water.
  • the keratin softening precursor composition of the present invention contains a bioactive glass and water. That is, it is a composition in which the bioactive glass is mixed with an aqueous solvent.
  • the mixing ratio of the bioactive glass and the aqueous solvent is not particularly limited as long as the bioactive glass extract can effectively function as a cuticle remover.
  • the content of the bioactive glass is preferably 2% by weight or more based on 100% by weight of the bioactive glass-containing liquid in order to effectively extract the active ingredient contained in the bioactive glass.
  • the content of the aqueous solvent is preferably 98% by weight or less based on 100% by weight of the bioactive glass-containing liquid.
  • the content of the bioactive glass is 100% by weight. Is preferably 50% by weight or less, more preferably 40% by weight or less, still more preferably 30% by weight or less, still more preferably 20% by weight or less, and more preferably 10% by weight. It is particularly preferred that:
  • the content of the aqueous solvent is preferably 50% by weight or more, more preferably 60% by weight or more, and preferably 70% by weight or more based on 100% by weight of the bioactive glass-containing liquid. More preferably, it is even more preferably 80% by weight or more, and particularly preferably 90% by weight or more.
  • the time for mixing the bioactive glass in water is not particularly limited as long as the ion can be sufficiently extracted from the bioactive glass, but is, for example, 1 minute to 100,000 hours, 2 minutes to 5000 hours, 3 minutes to 3000 hours, 5 minutes to 1000 hours, 6 minutes to 500 hours, 7 minutes to 300 hours, 8 minutes to 200 hours, 10 minutes to 100 hours It is as follows.
  • the time is preferably from 8 minutes to 200 hours, and more preferably from 10 minutes to 100 hours.
  • the method of mixing the bioactive glass is not particularly limited, and for example, the mixing can be performed using an apparatus such as an ultrasonic oscillator, a shaker, a mixer, and a stirrer.
  • the method of filtration is not particularly limited.
  • the keratin softening precursor composition is subjected to suction filtration using a filter having a pore size smaller than the average particle size of the bioactive glass, and the pH of the filtered solution is adjusted to 8 or more and 10 or less, and the present embodiment To a keratin softening composition.
  • the content of the bioactive glass extract is 30% by weight or more, preferably 40% by weight or more, more preferably 50% by weight or more based on 100% by weight of the cuticle remover. preferable.
  • the keratin softening composition of the present invention can exhibit the following effects not found in conventional keratin softeners. 1. Effect of suppressing skin redness It has been clarified that by including an extract from bioactive glass, redness caused by ultraviolet treatment or damage to a chemical skin barrier is suppressed. 2. Effect of making wrinkles less noticeable Including an extract from bioactive glass has been shown to significantly reduce the length and depth of wrinkles in a short period of time in a visible way. 3. Antioxidant Effect The inclusion of extracts from bioactive glass has been shown to exert distinct antioxidant effects in in vitro protein carbonyl assays and other test environments.
  • the keratin softening composition of the present invention has more effective cuticle removal and skin softening performance in the care of the hairline of the nail, fingertips and soles.
  • the keratin softening composition of the present invention is suitable for a so-called cuticle remover.
  • the above-mentioned cuticle remover is applied to the cuticle and the skin around the cuticle at room temperature, and after leaving for at least 30 seconds, cuticle is removed or pushed up to the base of the nail.
  • the keratin softening composition is applied to the skin and left at room temperature for 30 seconds to reduce the softening effect of cuticle. Obtainable.
  • FIG. 1 is a diagram comparing the state of keratin around the nail after (a) use and (b) after use of the keratin softening composition according to one embodiment of the present invention.
  • FIG. 1 (a) before use it can be observed that the cuticle is attached mainly at the site surrounded by the round frame.
  • FIG. 1 (b) when the keratin softening composition of the present invention is used for this nail, the cuticle can be removed cleanly.
  • FIG. 2 is a diagram comparing the keratin conditions around the sole (heel) before (a) use and (b) after use of the keratin softening composition according to one embodiment of the present invention.
  • FIG. 2 (a) before use it can be observed that the keratin on the surface of the heel is white and grooved (cracked).
  • FIG. 2 (b) after use when the keratin softening composition of the present invention is used for the heel, white groove-like cracks can be removed.
  • Bioactive glass extract A 1000 g of a mixture consisting of 98% by weight of distilled water and 2% by weight of bioactive glass (Vitryxx) is prepared in a glass bottle, shaken for 24 hours, and allowed to stand for 1 hour or more to precipitate the bioactive glass. I let it. Subsequently, the supernatant was suction-filtered using a hydrophilic PTFE filter (pore diameter: 0.5 ⁇ m) to produce a bioactive glass extract.
  • Bioactive glass extract B 1000 g of a mixture consisting of 96% by weight of distilled water and 4% by weight of bioactive glass (Vitryxx) is prepared in a glass bottle, shaken for 24 hours, and allowed to stand for 1 hour or more to precipitate the bioactive glass. I let it. Subsequently, the supernatant was suction-filtered using a hydrophilic PTFE filter (pore diameter: 0.5 ⁇ m) to produce a bioactive glass extract.
  • a hydrophilic PTFE filter pore diameter: 0.5 ⁇ m
  • the keratin softening compositions of the following Examples, Comparative Examples and Reference Examples are slightly alkaline, having a pH of about 9 to 11.
  • the keratin softening compositions of Example 4-6 and Comparative Example 4-6 were filled in a PE bottle container (20 mL, inner stopper nozzle container), and used as a cosmetic for cuticle treatment generated at the base of nails of fingers and toes. .
  • the keratin softening composition of Example 4-6 was applied to the cuticle and the skin around the cuticle, and after leaving for 30 seconds, the cuticle was removed or pushed up to the base of the nail. As a result, the cuticle was softened in a short time and easily removed. Or it was possible to push up to the base of the nail.
  • the keratin softening composition of Comparative Example 4-6 showed no cuticle or keratin softening even after being left for 30 seconds and 60 seconds after application.
  • the keratin softening compositions of Reference Example 1-3 and Comparative Example 1-3 were filled in a PE bottle (20 mL, spray type container) and used as a cosmetic for removing keratin of soles and heels.
  • the keratin softening composition of Reference Example 1-3 was sprayed on the sole and the heel, and after standing for 30 seconds, the keratin of the sole and the heel was removed with a foot file (file for the sole). And was easily removable.
  • the keratin softening composition of Comparative Example 1-3 did not show keratin softening even after being left for 30 seconds and 60 seconds after application.
  • the keratin softening compositions of Example 10-12 and Comparative Example 10-12 were filled into PE bottle containers (20 mL, inner stopper nozzle containers), and used as cosmetics for cuticle treatment generated at the base of nails of fingers and toes. .
  • the keratin softening composition of Examples 10-12 was applied to the cuticle and the skin around the cuticle, and after leaving for 30 seconds, the cuticle was removed or pushed up to the base of the nail. As a result, the cuticle was softened in a short time and easily removed. Or it was possible to push up to the base of the nail.
  • the keratin softening compositions of Comparative Examples 10-12 showed no cuticle or keratin softening even after standing for 30 seconds and 60 seconds after application.
  • the keratin softening compositions of Reference Examples 7 and 8, Example 9 and Comparative Examples 7-9 were filled in PE bottle containers (20 mL, spray type container) and used as cosmetics for removing keratin of soles and heels.
  • the keratin softening compositions of Reference Examples 7, 8 and 9 were sprayed on the soles and heels, and after standing for 30 seconds, the keratins of the soles and heels were removed with a foot file (file for soles). The keratin was softened and could be easily removed.
  • the keratin softening compositions of Comparative Examples 7-9 did not show keratin softening even after being left for 30 seconds and 60 seconds after application.
  • the keratin softening compositions of Examples 16-18, 22-27, Reference Example 28, Example 29, and Reference Example 30 were filled in PE bottle containers (20 mL, inner stopper nozzle containers), and the bases of the fingers and toenails were caught. This was used as a cuticle treatment cosmetic.
  • the keratin softening compositions of Examples 16-18, Examples 22-27, Reference Examples 28, 29 and Reference Example 30 are applied to cuticles and skin around the cuticles, and after leaving for 30 seconds, cuticles are removed or applied to the base of nails. As a result of pushing up, the cuticle was softened in a short time, and it could be easily removed or pushed up to the base of the nail.
  • the keratin softening compositions of Reference Examples 13-15 and 19-21 were filled in a PE bottle (20 mL, spray type container) and used as a cosmetic for removing keratin on soles and heels.
  • the keratin softening compositions of Reference Examples 13-15 and 19-21 were sprayed on the soles and heels, and after standing for 30 seconds, the keratins on the soles and heels were removed with a foot file (file for the soles). The keratin was softened and could be easily removed.
  • the keratin softening composition of Reference Examples 31 to 36 was filled in a PE bottle container (20 mL, inner stopper nozzle container) and used as a cuticle treatment cosmetic formed at the base of the finger and toe nails.
  • the keratin softening composition of Reference Examples 31-36 was applied to cuticle and the skin around the cuticle, and after leaving for 30 seconds, the cuticle was removed or pushed up to the base of the nail. As a result, the cuticle was softened in a short time and easily removed. Or it was possible to push up to the base of the nail.
  • the keratin softening composition of Reference Examples 31 to 36 was filled in a PE bottle (20 mL, spray type container) and used as a cosmetic for removing keratin of soles and heels.
  • the keratin softening composition of Reference Examples 31-36 was sprayed on the soles and heels, and after standing for 30 seconds, the keratins on the soles and heels were removed with a foot file (file for soles). And was easily removable.
  • Examples 37-44, Reference Example 45, Example 46, Reference Example 47, Example 48, Comparative Examples 13-18 According to the composition table 9-11 described in Table 9-11, each component was weighed and mixed at a liquid temperature of 60 ° C. for 6 hours using a homomixer to obtain a keratin softening composition.
  • Each of the keratin softening compositions of Examples 37-44, Reference Example 45, Example 46, Reference Example 47, Example 48, and Comparative Examples 13-18 was filled into a PE bottle (20 mL, inner plug nozzle container), It was used as a cosmetic for cuticle treatment generated at the base of the toenails.
  • the keratin softening compositions of Examples 37-44, Reference Example 45, Example 46, Reference Example 47, and Example 48 were applied to cuticle and the skin around the cuticle, and after leaving for 30 seconds, the cuticle was removed or pushed up to the base of the nail. As a result, the cuticle was softened in a short time, and it could be easily removed or pushed up to the base of the nail.
  • the keratin softening compositions of Comparative Examples 13-18 even after leaving for 30 seconds and 60 seconds after application, no softening of cuticle and keratin was observed.
  • ⁇ Test 2> Reconfirmation of the keratin softening effect of the bioactive glass extract
  • a composition containing a commercially available alkaline liquid as a main component and a bioactive glass extract A The difference in the feeling of use due to the composition containing as a main component was examined.
  • composition table of keratin softening composition (Composition table of keratin softening composition)
  • Example 5 Composition 1 was filled in a PE bottle container (20 mL, inner stopper nozzle container), and used as a cuticle treatment cosmetic formed at the base of the finger and toe nails.
  • Example 5 The composition 1 was applied to cuticle and the skin around the cuticle, and after leaving for 30 seconds, cuticle was removed or pushed up to the base of the nail.
  • composition containing a bioactive glass extract as a main component was superior in use feeling to a composition having an equivalent pH not containing a bioactive glass extract as a main component.

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Abstract

[Problem] To provide a keratin-softening composition which causes less skin irritation and is less corrosive, and provides more effective cuticle removal and skin-softening performance in the care of proximal nail folds or fingertips, and soles. [Solution] The cuticle remover according to the present invention has a pH of 8-10 and contains a bioactive glass extract obtained by removing a bioactive glass from a bioactive glass-containing solution containing 2-50 wt% of the bioactive glass and 50-98 wt% of an aqueous solvent, wherein the content of the bioactive glass extract is at least 30 wt% with respect to 100 wt% of the cuticle remover. The cuticle remover is applied at room temperature to cuticles and the skin around the cuticles, and is left alone for at least 30 seconds, after which cuticle removal or nail root push-up is performed. Accordingly, the cuticle remover can achieve a sufficient cuticle-softening effect despite having the same pH as that of everyday soap water and alkaline hot springs.

Description

キューティクルリムーバー、並びにその製造方法及び使用方法Cuticle remover, and method for producing and using the same
　本発明は、爪の甘皮及び皮膚の角質を効果的に軟化することが出来るキューティクルリムーバー、並びにその製造方法及び使用方法に関する。 {Circle over (1)} The present invention relates to a cuticle remover capable of effectively softening the cuticle of the nail and the keratin of the skin, and a method for producing and using the same.
　爪の生え際にある薄い皮膚は甘皮又はキューティクルと呼ばれる。甘皮は爪を作り出す部分を保護するための組織だが、必要以上にあると爪に必要な水分を奪ってしまったり、爪・指先の美しさを損なったり、美爪料をきれいに塗布することの妨げとなる。そのため、美爪料をきれいに塗布するために甘皮の除去や爪根元への押し上げが行われ、その際にキューティクルリムーバーが用いられる。キューティクルリムーバーは液状またはクリーム状の組成物であり、短時間で甘皮を軟化させ甘皮の除去や爪根元への押し上げ操作が容易になる。 薄 い Thin skin at the nail hairline is called cuticle or cuticle. Cuticle is a tissue that protects the parts that make up the nails.However, if it is more than necessary, it will remove the water required for the nails, impair the beauty of the nails and fingertips, and prevent the application of beautiful nails Becomes Therefore, the cuticle is removed and the nail is pushed up to the base of the nail to cleanly apply the nail material, and a cuticle remover is used at that time. The cuticle remover is a liquid or creamy composition that softens the cuticle in a short period of time and facilitates removal of cuticle and pushing up to the base of the nail.
　また、足裏やかかとは体重を支えるために、圧力や摩擦が負荷されており、古い皮膚が蓄積されやすい場所である。そのため定期的に角質の除去が必要であり、角質の除去を怠ると足裏やかかとの美的外観を損なうだけでなく、皮膚の表面が乾燥して肌荒れを起してしまう場合がある。足裏やかかとの角質の除去においても、液状またはクリーム状、シート状の角質軟化剤が用いられ、柔らかくなった角質をファイル（やすり）等で除去する操作が行われる。 裏 In addition, the soles and heels are places where pressure and friction are applied to support weight, and old skin tends to accumulate. For this reason, it is necessary to periodically remove the keratin, and if the keratin is not neglected, not only the aesthetic appearance of the soles and heels may be impaired, but also the skin surface may dry and cause rough skin. In removing the calluses of the soles and heels, a liquid, creamy, or sheet-like keratin softener is used, and an operation of removing softened keratin with a file (file) is performed.
　特許文献１には甘皮除去効果を有するネイルケア用組成物が開示されている。詳しくは、アルカリ剤、アミノ酸、及び水溶性高分子を含むことを特徴とするネイルケア用組成物であり、アルカリ材剤としては、水酸化ナトリウム、水酸化カリウム、炭酸ナトリウム、炭酸カリウム、炭酸水素ナトリウム、炭酸水素カリウム等の無機アルカリ剤が挙げられている。しかし、当該アルカリ材は甘皮除去及び皮膚軟化効果は優れている一方で、皮膚刺激性、腐食性を有する事が問題である。 Patent Document 1 discloses a nail care composition having a cuticle removal effect. Specifically, it is a nail care composition characterized by containing an alkali agent, an amino acid, and a water-soluble polymer. Examples of the alkali agent include sodium hydroxide, potassium hydroxide, sodium carbonate, potassium carbonate, and sodium hydrogen carbonate. And inorganic alkali agents such as potassium bicarbonate. However, there is a problem in that the alkali material has excellent skin cutoff and emollient effects, but has skin irritation and corrosiveness.
　特許文献２には甘皮を除去する高いｐＨを長期間維持するキューティクルリムーバーが開示されている。詳しくは、ＰＯＥ・ＰＯＰアルキルエーテル、及び炭酸アルカリ金属塩を含有し、ｐＨが１０以上である、キューティクルリムーバーである。炭酸アルカリ金属塩を用いることにより皮膚刺激性、腐食性を低減することが可能であるが、甘皮除去及び皮膚軟化効果は低下する事が問題である。 Patent Document 2 discloses a cuticle remover that removes cuticle and maintains a high pH for a long period of time. Specifically, it is a cuticle remover containing POE / POP alkyl ether and an alkali metal carbonate and having a pH of 10 or more. It is possible to reduce skin irritation and corrosiveness by using an alkali metal carbonate, but there is a problem that the cuticle removal and emollient effects are reduced.
　近年、ネイルサロン等では指先や足指の美粧としてネイルポリッシュやジェルネイルの施術以外にも爪の生え際や指先及び、足裏のケアが重要視されており、より効果的な甘皮除去及び皮膚軟化性能を有し、皮膚刺激性、腐食性の低減された角質軟化組成物が求められている。 In recent years, in nail salons, care for nail hairline, fingertips, and soles has been regarded as important in addition to nail polish and gel nail treatments as cosmetics for fingertips and toes, and more effective cuticle removal and skin softening There is a need for a keratin softening composition that has performance and reduced skin irritation and corrosivity.
　近年、医療分野において人体の健康を損ねることなく体液・人体組織に作用するという特性から生体活性材料に注目が集まっている。特に、外科手術の分野では人体組織の置換・修復用素材として多用されており、生体活性材料の主な原材料は、セラミック、ガラス、ガラスセラミックス、およびそれらの混合物（複合材料）等である。ここで、生体活性ガラスは生体活性材料の重要なカテゴリーのひとつで、生体の健康や組織に影響を及ぼすことなく体液や組織と相互作用することを通して自然治癒を促進する。生体活性ガラスは、シリコン、カルシウム、ナトリウム、およびリンで構成されており、整形外科分野で広く使用されており、次いで歯科分野や化粧品産業にも応用されており、粉末やナノパウダーといった形態で販売されている。 In recent years, attention has been focused on bioactive materials in the medical field because of their ability to act on body fluids and tissues without impairing human health. In particular, in the field of surgery, it is frequently used as a material for replacement and repair of human body tissue, and the main raw materials of bioactive materials are ceramics, glass, glass ceramics, and mixtures thereof (composite materials). Here, bioactive glass is one of the important categories of bioactive materials, and promotes natural healing by interacting with body fluids and tissues without affecting the health and tissues of the living body. Bioactive glass is composed of silicon, calcium, sodium, and phosphorus, is widely used in the field of orthopedics, and is also applied to the dental and cosmetic industries, and is sold in the form of powder and nano powder. Have been.
特開２００６－５２１５４号公報JP 2006-52154 A 特開２０１８－２６３６号公報JP 2018-2636 A
　本発明は、爪の生え際や指先及び、足裏のケアにおいてより効果的な甘皮除去及び皮膚軟化性能を有し、皮膚刺激性、腐食性の低減された角質軟化組成物を提供することを目的とする。 An object of the present invention is to provide a keratin softening composition that has more effective cuticle removal and emollient performance in the care of the hairline, fingertips, and soles of nails, and has reduced skin irritation and corrosivity. And
　本発明のキューティクルリムーバーは、生体活性ガラス２重量％～５０重量％と水系溶媒９８重量％～５０重量％とを含有する生体活性ガラス含有液から前記生体活性ガラスが除去されることによって得られた生体活性ガラス抽出物を含有し、前記生体活性ガラス抽出物の含有量がキューティクルリムーバー１００重量％に対して３０重量％以上であり、ｐＨが８以上１０以下である。 The cuticle remover of the present invention is obtained by removing the bioactive glass from the bioactive glass-containing liquid containing 2% to 50% by weight of the bioactive glass and 98% to 50% by weight of the aqueous solvent. It contains a bioactive glass extract, and the content of the bioactive glass extract is 30% by weight or more based on 100% by weight of the cuticle remover, and the pH is 8 or more and 10 or less.
　また、本発明のキューティクルリムーバーは、保湿剤及び増粘剤をさらに含有することが好ましい。 キ ュ ー The cuticle remover of the present invention preferably further contains a humectant and a thickener.
　また、本発明に係るキューティクルリムーバーの製造方法は、２重量％～５０重量％の生体活性ガラスを、１分以上１００，０００時間以下の間、９８重量％～５０重量％の水系溶媒中で混合して、生体活性ガラス、及び前記生体活性ガラスからの抽出物を含む角質軟化前駆組成物を生成する抽出ステップと、前記角質軟化前駆組成物をろ過して前記生体活性ガラスを除去し、ｐＨを８以上１０以下に調整して、前記抽出物からなるキューティクルリムーバーを生成するろ過ステップと、を含み、前記抽出物の含有量がキューティクルリムーバー１００重量％に対して３０重量％以上である。 Further, the method for producing a cuticle remover according to the present invention comprises mixing 2% to 50% by weight of bioactive glass in 98% to 50% by weight of an aqueous solvent for 1 minute to 100,000 hours. Then, a bioactive glass, and an extraction step of producing a keratin softening precursor composition including an extract from the bioactive glass, and filtering the keratin softening precursor composition to remove the bioactive glass, pH A filtration step of producing a cuticle remover made of the extract by adjusting the extractor to 8 or more and 10 or less, wherein the content of the extract is 30% by weight or more based on 100% by weight of the cuticle remover.
　また、本発明に係るキューティクルリムーバーの使用方法は、本発明のキューティクルリムーバーを甘皮及び甘皮周辺の皮膚に室温で適用し、３０秒間以上放置後に甘皮除去又は爪根元への押し上げを行うステップを含む。 The method of using the cuticle remover according to the present invention includes a step of applying the cuticle remover of the present invention to cuticle and the skin around the cuticle at room temperature, and removing cuticle or pushing up to the base of the nail after being left for 30 seconds or more.
　本発明のキューティクルリムーバーは、手指及び足指の爪根元に生じる甘皮を柔らかくし、除去又は爪根元への押し上げをする事を助けるとともに、手指及び足指の爪周辺、かかと及び足裏の角質化された皮膚を柔らかくし、除去する事を助ける化粧料である。 The cuticle remover of the present invention softens the cuticle generated at the base of the nails of the fingers and toes, helps to remove or push up to the base of the nails, and keratinizes around the nails of the fingers and toes, heels and soles. It is a cosmetic that helps soften and remove irritated skin.
本発明の一実施形態にかかる角質軟化組成物の（ａ）使用前と（ｂ）使用後の爪周辺の角質の様子を比較した図である。BRIEF DESCRIPTION OF THE DRAWINGS It is the figure which compared the state of the keratin around the nail | claw of (a) before use of the keratin softening composition which concerns on one Embodiment of this invention, and (b) after use. 本発明の一実施形態にかかる角質軟化組成物の（ａ）使用前と（ｂ）使用後の足裏（かかと）周辺の角質の様子を比較した図である。BRIEF DESCRIPTION OF THE DRAWINGS It is the figure which compared the state of the keratin near the sole (heel) of (a) before use and (b) after use of the keratin softening composition concerning one Embodiment of this invention.
　本発明には種々の代替形態が可能であるが、本明細書では本発明の特定の態様について詳述する。しかしながら、本明細書における特定の態様の記述は、本発明を特定の形態に限定しようと意図するものではなく、本発明は特許請求の範囲に規定した本発明の真意および範囲に含まれる全ての代替形を包含できる。 While the invention is capable of various alternative forms, certain aspects of the invention will be described in detail herein. However, the description of particular embodiments herein is not intended to limit the invention to the particular form, which is intended to cover all aspects of the invention that fall within the true spirit and scope of the invention as defined by the appended claims. Alternative forms can be included.
＜角質軟化組成物＞
　本発明の角質軟化組成物とは、手指及び足指の爪根元に生じる甘皮を柔らかくし、除去又は爪根元への押し上げをする事を助けるとともに、手指及び足指の爪周辺、かかと及び足裏の角質化された皮膚を柔らかくし、除去する事を助ける化粧料である。 <Keratin softening composition>
The keratin softening composition of the present invention softens the cuticle generated at the base of the finger and toe nails, and helps to remove or push up to the base of the nail, and also around the nails of the finger and toe, the heel and the sole. Is a cosmetic that helps soften and remove keratinized skin.
　本発明の角質軟化組成物とは、生体活性ガラスからの抽出物を含む事を特徴とする。
　本発明の角質軟化組成物は、保湿剤及び増粘剤をさらに含んでいてもよい。 The keratin softening composition of the present invention is characterized by containing an extract from bioactive glass.
The keratin softening composition of the present invention may further include a humectant and a thickener.
〔生体活性ガラス抽出物〕
　生体活性ガラス抽出物は、生体活性ガラス２重量％～５０重量％と水系溶媒９８重量％～５０重量％とを含有する生体活性ガラス含有液から生体活性ガラスが除去されることによって得られる。 (Bioactive glass extract)
The bioactive glass extract is obtained by removing the bioactive glass from a bioactive glass-containing liquid containing 2% to 50% by weight of the bioactive glass and 98% to 50% by weight of the aqueous solvent.
［生体活性ガラス］
　本発明における生体活性ガラスとは、二酸化ケイ素及び酸化ナトリウム、酸化カルシウム、五酸化リンを含む粉末状ガラス物質である。生体活性ガラスは水分により活性化され、高い生物学的利用能を有する構成成分のイオン（生体活性ガラスからの抽出物）が放出される、特に本発明の角質軟化組成物においてはナトリウムイオン及びカルシウムイオンが角質軟化効果に効果的である。 [Bioactive glass]
The bioactive glass in the present invention is a powdery glass material containing silicon dioxide, sodium oxide, calcium oxide, and phosphorus pentoxide. The bioactive glass is activated by moisture and releases ions of the components with high bioavailability (extracts from the bioactive glass), especially sodium ions and calcium in the keratin softening composition of the present invention. The ions are effective for the keratin softening effect.
　生体活性ガラスは、アルカリイオンを徐放する崩壊性を有するガラスであれば特に制限されないが、例えば、歯科材料で用いられるフルオロアルミノシリケートガラスや、ＳＣＨＯＴＴ社のＶｉｔｒｙｘｘ等が挙げられる。 The bioactive glass is not particularly limited as long as it is a glass having a disintegrating property for gradually releasing alkali ions, and examples thereof include fluoroaluminosilicate glass used for dental materials, Vitryxx manufactured by SCHOTT, and the like.
　生体活性ガラスの平均粒子径は、特に制限されないが、例えば、２．０μｍ、３．０μｍ、５．０μｍ、８．０μｍ、１０．０μｍ、１５．０μｍ等でもよく、これらの数値のいずれかの範囲でもよい。 The average particle size of the bioactive glass is not particularly limited, but may be, for example, 2.0 μm, 3.0 μm, 5.0 μm, 8.0 μm, 10.0 μm, 15.0 μm, or any of these numerical values. It may be a range.
　中でも、生体活性ガラスに含まれるキューティクルリムーバーとしての有効成分を水系溶媒に抽出し易いことから、生体活性ガラスの平均粒子径は、１５．０μｍ以下であることが好ましく、１０．０μｍ以下であることがより好ましく、８．０μｍ以下であることがさらに好ましく、５．０μｍ以下であることがよりさらに好ましい。 Among them, the average particle diameter of the bioactive glass is preferably 15.0 μm or less, and more preferably 10.0 μm or less, since the active ingredient as a cuticle remover contained in the bioactive glass is easily extracted into an aqueous solvent. Is more preferably, 8.0 μm or less, further preferably, 5.0 μm or less.
　他方で、キューティクルリムーバーの製造工程である、抽出ステップ及びろ過ステップの作業容易性の観点から、生体活性ガラスの平均粒子径は、０．５μｍ以上であることが好ましく、１．０μｍ以上であることがより好ましい。 On the other hand, the average particle size of the bioactive glass is preferably 0.5 μm or more, and more preferably 1.0 μm or more, from the viewpoint of the workability of the extraction step and the filtration step, which is the production process of the cuticle remover. Is more preferred.
［水系溶媒］
　本発明における生体活性ガラスからの抽出物とは、一例として生体活性ガラスを適切な溶媒（水またはｔｒｉｓ緩衝液等）の中で適切な時間混合することによって製造される溶液を意味することを意図しており、そしてその溶液は次いで濾過されて生体活性ガラス抽出物となる。 [Aqueous solvent]
The extract from the bioactive glass in the present invention is intended to mean, as an example, a solution produced by mixing the bioactive glass in a suitable solvent (such as water or a tris buffer) for a suitable time. And the solution is then filtered to a bioactive glass extract.
　本実施形態において、水系溶媒は、生体活性ガラスに含まれるキューティクルリムーバーとしての有効成分を、有効成分としての機能を損なうことなく抽出可能な液体であれば特に限定されるものでなく、水、水混和性溶媒、水溶性成分の水溶液、及びこれら２種以上の混合溶媒のいずれも含む包括概念である。 In the present embodiment, the aqueous solvent is not particularly limited as long as it is a liquid that can extract the active ingredient contained in the bioactive glass as a cuticle remover without impairing the function as the active ingredient. This is a general concept including both a miscible solvent, an aqueous solution of a water-soluble component, and a mixed solvent of two or more of these.
　水は、精製水、イオン交換水、水道水等、常温で液体の状態にあるあらゆる態様を含む。 Water includes all forms of liquid at room temperature, such as purified water, ion-exchanged water, and tap water.
　水混和性溶媒は、例えば、メタノール、エタノール、ｎ－プロパノール、イソプロパノール、ｎ－ブタノール、ｓ－ブタノール、イソブタノール、ｔ－ブタノール等のＣ１－４アルコール；アセトン等のケトン系溶媒；ジメチルホルムアミドやジメチルアセトアミド等のアミド系溶媒；ジメチルスルホキシド等のスルホキシド系溶媒；アセトニトリル等のニトリル系溶媒；酢酸等の有機酸溶媒等が挙げられる。中でも、生体活性ガラス抽出物を甘皮及び甘皮周辺の皮膚等に接触させることを考慮すると、水混和性溶媒は、エタノール又はイソプロパノールであることが好ましく、エタノールであることがより好ましい。 Water-miscible solvents include, for example, C1-4 alcohols such as methanol, ethanol, n-propanol, isopropanol, n-butanol, s-butanol, isobutanol, t-butanol; ketone solvents such as acetone; dimethylformamide and dimethyl Amide solvents such as acetamide; sulfoxide solvents such as dimethyl sulfoxide; nitrile solvents such as acetonitrile; organic acid solvents such as acetic acid. Above all, in consideration of bringing the bioactive glass extract into contact with cuticle and the skin around cuticle, the water-miscible solvent is preferably ethanol or isopropanol, and more preferably ethanol.
　水溶性成分は、本発明の効果を損なわないものであれば特に制限無く用いることができ、例えば、通常化粧料や医薬部外品等に配合される粉末類、保湿剤、増粘剤、防腐剤等の添加物が挙げられる。その他、水溶性成分の水溶液としては、ｔｒｉｓ緩衝液等も挙げられる。 The water-soluble component can be used without any particular limitation as long as it does not impair the effects of the present invention. For example, powders, humectants, thickeners, and preservatives that are usually blended in cosmetics, quasi-drugs, etc. And additives such as agents. Other examples of the aqueous solution of the water-soluble component include a tris buffer.
［生体活性ガラス含有液に含まれる生体活性ガラスと水系溶媒との割合］
　生体活性ガラス含有液に含まれる生体活性ガラスと水系溶媒との割合は、生体活性ガラス抽出物において、キューティクルリムーバーとしての機能を有効に発揮できれば、特に限定されるものではない。 [Ratio of bioactive glass and aqueous solvent contained in bioactive glass-containing liquid]
The ratio between the bioactive glass and the aqueous solvent contained in the bioactive glass-containing liquid is not particularly limited as long as the bioactive glass extract can effectively exhibit the function as a cuticle remover.
　目安ではあるが、生体活性ガラスに含まれる有効成分を効果的に抽出させるため、生体活性ガラスの含有量は、生体活性ガラス含有液１００重量％に対して２重量％以上であることが好ましい。言い換えると、水系溶媒の含有量は、生体活性ガラス含有液１００重量％に対して９８重量％以下であることが好ましい。 As a guide, the content of the bioactive glass is preferably 2% by weight or more based on 100% by weight of the bioactive glass-containing liquid in order to effectively extract the active ingredient contained in the bioactive glass. In other words, the content of the aqueous solvent is preferably 98% by weight or less based on 100% by weight of the bioactive glass-containing liquid.
　また、生体活性ガラス含有液から生体活性ガラスを除去したときに十分な量の生体活性ガラス抽出物（ろ過後液）を得るため、生体活性ガラスの含有量は、生体活性ガラス含有液１００重量％に対して５０重量％以下であることが好ましく、４０重量％以下であることがより好ましく、３０重量％以下であることがさらに好ましく、２０重量％以下であることがよりさらに好ましく、１０重量％以下であることが特に好ましい。言い換えると、水系溶媒の含有量は、生体活性ガラス含有液１００重量％に対して５０重量％以上であることが好ましく、６０重量％以上であることがより好ましく、７０重量％以上であることがさらに好ましく、８０重量％以上であることがよりさらに好ましく、９０重量％以上であることが特に好ましい。 In order to obtain a sufficient amount of the bioactive glass extract (filtered solution) when the bioactive glass is removed from the bioactive glass-containing liquid, the content of the bioactive glass is 100% by weight. Is preferably 50% by weight or less, more preferably 40% by weight or less, still more preferably 30% by weight or less, still more preferably 20% by weight or less, and more preferably 10% by weight. It is particularly preferred that: In other words, the content of the aqueous solvent is preferably 50% by weight or more, more preferably 60% by weight or more, and preferably 70% by weight or more based on 100% by weight of the bioactive glass-containing liquid. More preferably, it is even more preferably 80% by weight or more, and particularly preferably 90% by weight or more.
［生体活性ガラス抽出物の含有量］
　本実施形態において、生体活性ガラス抽出物の含有量は、キューティクルリムーバー１００重量％に対して３０重量％以上であり、４０重量％以上であることがより好ましく、５０重量％以上であることがさらに好ましい。十分な量の生体活性ガラス抽出物を含有することで、爪の生え際や指先及び、足裏のケアにおいてより効果的な甘皮除去及び皮膚軟化性能を発揮することができる。 [Content of bioactive glass extract]
In this embodiment, the content of the bioactive glass extract is 30% by weight or more, preferably 40% by weight or more, more preferably 50% by weight or more based on 100% by weight of the cuticle remover. preferable. By containing a sufficient amount of the bioactive glass extract, more effective cuticle removal and emollient performance can be exhibited in the care of the hairline, fingertips and soles of nails.
［ｐＨ］
　本発明の角質軟化組成物のｐＨは、角質軟化作用を発揮することができれば特に制限されないが、例えば、７、８、９、１０、１１、１２等でもよく、これらの数値のいずれかの範囲でもよい。具体的に、ｐＨは、８以上であることがより好ましく、８．５以上であることがさらに好ましく、９以上であることがよりさらに好ましく、９．５以上であることが特に好ましい。 [PH]
The pH of the keratin softening composition of the present invention is not particularly limited as long as it can exert a keratin softening action, and may be, for example, 7, 8, 9, 10, 11, 12, or the like, and may be in any range of these numerical values. May be. Specifically, the pH is more preferably 8 or more, further preferably 8.5 or more, even more preferably 9 or more, and particularly preferably 9.5 or more.
　他方、皮膚へのダメージを低減する観点から、本発明の角質軟化組成物のｐＨは、弱アルカリ性であることが好ましく、１１以下であることが好ましく、１０．５以下であることがより好ましく、１０以下であることが特に好ましい。 On the other hand, from the viewpoint of reducing damage to the skin, the pH of the keratin softening composition of the present invention is preferably weakly alkaline, preferably 11 or less, more preferably 10.5 or less, Particularly preferred is 10 or less.
　ｐＨが８以上１１以下とは、日用品の石鹸水やアルカリ温泉と同等のｐＨである。これらは、室温・短時間では角質軟化効果は通常は認められないが、本発明の角質軟化組成物は、角質への浸透効果を高めるアルカリイオン成分（ミネラル成分）を含むため、室温・短時間でも角質軟化効果を発揮することができる。 The pH of 8 or more and 11 or less is equivalent to the pH of soap water or alkaline hot spring of daily necessities. These do not usually have a keratin softening effect at room temperature and for a short time, but the keratin softening composition of the present invention contains an alkali ion component (mineral component) that enhances the effect of penetrating into the keratin, so However, it can exhibit a keratin softening effect.
　従来の角質軟化剤は、ｐＨが１１よりも大きい強アルカリ性のものが主流であった。これらの角質軟化剤は、高い角質軟化効果を発揮する一方で、皮膚刺激性、腐食性が高く、皮膚にダメージを与えてしまうという問題があった。 Conventional keratin softeners are mainly alkaline and have a pH of greater than 11. While these keratin softeners exhibit a high keratin softening effect, there is a problem that the skin is highly irritating and corrosive, causing damage to the skin.
　しかしながら、本発明の角質軟化剤は、ｐＨを弱アルカリ性に抑えたとしても、高い角質軟化効果を発揮することから、高い角質軟化効果と、皮膚へのダメージの低減を両立することができるものである。 However, the keratin softener of the present invention exerts a high keratin softening effect even when the pH is suppressed to a weak alkalinity, so that both a high keratin softening effect and reduction of damage to the skin can be achieved. is there.
［その他の成分］
　本実施形態に記載の角質軟化組成物（キューティクルリムーバーは、その一態様である）は、本発明の効果を損なわない程度において、その他の成分を含有するものであってもよい。その他の成分としては、増粘剤、湿潤剤・保湿剤、有機溶剤、防腐剤、界面活性剤、香料、オイル、着色剤等が挙げられる。増粘剤、有機溶剤等は、適切な粘性や揮発性を付与するために用いられる。 [Other ingredients]
The keratin softening composition (cuticle remover is one aspect thereof) described in the present embodiment may contain other components as long as the effects of the present invention are not impaired. Other components include a thickener, a humectant / humectant, an organic solvent, a preservative, a surfactant, a fragrance, an oil, a colorant, and the like. Thickeners, organic solvents, and the like are used to impart appropriate viscosity and volatility.
　増粘剤とは、角質軟化組成物の粘度を向上させて、ゲル状やクリーム状にするために用いる添加物である。増粘剤は、例えば、クラリアントジャパン社「アリストフレックスＨＭＢ」、カルボキシビニルポリマーに代表される合成ポリマー、ペクチンやキサンタンガム等に代表される天然ポリマー、微粒子シリカやベントナイト、ヘクトナイト等が挙げられる。 粘 A thickener is an additive used to increase the viscosity of the keratin softening composition to make it into a gel or cream. Examples of the thickener include “Aristoflex HMB” by Clariant Japan, a synthetic polymer represented by carboxyvinyl polymer, a natural polymer represented by pectin and xanthan gum, fine particle silica, bentonite, and hectonite.
　湿潤剤・保湿剤とは、角質軟化組成物を使用して角質を除去した後に、角質を除去した患部を保湿する目的で用いる添加物である。湿潤剤・保湿剤は、例えば、ポリエチレングリコール６００（略号：ＰＥＧ６００）、グリセリン、アミノ酸、ピロリドンカルボン酸、乳酸、ヒアルロン酸、コンドロイチン硫酸等のムコ多糖葵質、グリセリン、プロピレングリコール、ブチレングリコール、ソルビット等の多価アルコール類等が挙げられる。 (4) A humectant / humectant is an additive used for moisturizing an affected area from which keratin has been removed after removing keratin using a keratin softening composition. Examples of the humectant / humectant include polyethylene glycol 600 (abbreviation: PEG600), glycerin, amino acids, pyrrolidone carboxylic acid, lactic acid, hyaluronic acid, mucopolysaccharides such as chondroitin sulfate, glycerin, propylene glycol, butylene glycol, sorbit and the like. And the like polyhydric alcohols.
＜角質軟化組成物の製造方法＞
　本発明の角質軟化組成物の製造方法は、生体活性ガラスを１分以上１０００００時間以下の間水中で混合して、生体活性ガラス、前記生体活性ガラスからの抽出物、及び水を含む角質軟化前駆組成物を生成する抽出ステップと、前記角質軟化前駆組成物をろ過して前記生体活性ガラスを除去し、前記抽出物及び前記水を含む角質軟化組成物を生成するろ過ステップと、を含むものである。 <Method for producing keratin softening composition>
The method for producing a keratin softening composition of the present invention comprises mixing a bioactive glass in water for 1 minute to 100000 hours to form a keratin softening precursor containing the bioactive glass, an extract from the bioactive glass, and water. An extraction step for producing a composition, and a filtration step for filtering the keratin softening precursor composition to remove the bioactive glass and producing a keratin softening composition containing the extract and the water.
〔抽出ステップ〕
　本発明の角質軟化前駆組成物とは、生体活性ガラス及び水を含むものである。すなわち、生体活性ガラスを水系溶媒に混合させている状態の組成物のことである。 [Extraction step]
The keratin softening precursor composition of the present invention contains a bioactive glass and water. That is, it is a composition in which the bioactive glass is mixed with an aqueous solvent.
　上述したとおり、生体活性ガラスと水系溶媒との混合割合は、生体活性ガラス抽出物において、キューティクルリムーバーとしての機能を有効に発揮できれば、特に限定されるものではない。 と お り As described above, the mixing ratio of the bioactive glass and the aqueous solvent is not particularly limited as long as the bioactive glass extract can effectively function as a cuticle remover.
　目安ではあるが、生体活性ガラスに含まれる有効成分を効果的に抽出させるため、生体活性ガラスの含有量は、生体活性ガラス含有液１００重量％に対して２重量％以上であることが好ましい。言い換えると、水系溶媒の含有量は、生体活性ガラス含有液１００重量％に対して９８重量％以下であることが好ましい。 As a guide, the content of the bioactive glass is preferably 2% by weight or more based on 100% by weight of the bioactive glass-containing liquid in order to effectively extract the active ingredient contained in the bioactive glass. In other words, the content of the aqueous solvent is preferably 98% by weight or less based on 100% by weight of the bioactive glass-containing liquid.
　また、生体活性ガラス含有液から生体活性ガラスを除去したときに十分な量の生体活性ガラス抽出物（ろ過後液）を得るため、生体活性ガラスの含有量は、生体活性ガラス含有液１００重量％に対して５０重量％以下であることが好ましく、４０重量％以下であることがより好ましく、３０重量％以下であることがさらに好ましく、２０重量％以下であることがよりさらに好ましく、１０重量％以下であることが特に好ましい。言い換えると、水系溶媒の含有量は、生体活性ガラス含有液１００重量％に対して５０重量％以上であることが好ましく、６０重量％以上であることがより好ましく、７０重量％以上であることがさらに好ましく、８０重量％以上であることがよりさらに好ましく、９０重量％以上であることが特に好ましい。 In order to obtain a sufficient amount of the bioactive glass extract (filtered solution) when the bioactive glass is removed from the bioactive glass-containing liquid, the content of the bioactive glass is 100% by weight. Is preferably 50% by weight or less, more preferably 40% by weight or less, still more preferably 30% by weight or less, still more preferably 20% by weight or less, and more preferably 10% by weight. It is particularly preferred that: In other words, the content of the aqueous solvent is preferably 50% by weight or more, more preferably 60% by weight or more, and preferably 70% by weight or more based on 100% by weight of the bioactive glass-containing liquid. More preferably, it is even more preferably 80% by weight or more, and particularly preferably 90% by weight or more.
　生体活性ガラスを水中で混合する時間は、生体活性ガラスからイオンが十分に抽出できる時間であれば特に制限されないが、例えば、１分以上１０００００時間以下であり、２分以上５０００時間以下であり、３分以上３０００時間以下であり、５分以上１０００時間以下であり、６分以上５００時間以下であり、７分以上３００時間以下であり、８分以上２００時間以下であり、１０分以上１００時間以下である。
　安定的に生体活性ガラスからイオンを抽出するためには、８分以上２００時間以下であることが好ましく、１０分以上１００時間以下であることがさらに好ましい。 The time for mixing the bioactive glass in water is not particularly limited as long as the ion can be sufficiently extracted from the bioactive glass, but is, for example, 1 minute to 100,000 hours, 2 minutes to 5000 hours, 3 minutes to 3000 hours, 5 minutes to 1000 hours, 6 minutes to 500 hours, 7 minutes to 300 hours, 8 minutes to 200 hours, 10 minutes to 100 hours It is as follows.
In order to stably extract ions from the bioactive glass, the time is preferably from 8 minutes to 200 hours, and more preferably from 10 minutes to 100 hours.
　生体活性ガラスを混合する方法は、特に制限されないが、例えば、超音波発振器、シェーカー、ミキサー、スターラー等の機器を用いて混合することができる。 (4) The method of mixing the bioactive glass is not particularly limited, and for example, the mixing can be performed using an apparatus such as an ultrasonic oscillator, a shaker, a mixer, and a stirrer.
〔ろ過ステップ〕
　ろ過の手法は、特に限定されない。一態様として、角質軟化前駆組成物を、生体活性ガラスの平均粒子径よりも小さい細孔径のフィルターを使用して吸引濾過し、ろ過後液のｐＨを８以上１０以下に調整して本実施形態の角質軟化組成物にすることが挙げられる。 [Filtration step]
The method of filtration is not particularly limited. In one embodiment, the keratin softening precursor composition is subjected to suction filtration using a filter having a pore size smaller than the average particle size of the bioactive glass, and the pH of the filtered solution is adjusted to 8 or more and 10 or less, and the present embodiment To a keratin softening composition.
〔生体活性ガラス抽出物の含有量〕
　本実施形態において、生体活性ガラス抽出物の含有量は、キューティクルリムーバー１００重量％に対して３０重量％以上であり、４０重量％以上であることがより好ましく、５０重量％以上であることがさらに好ましい。十分な量の生体活性ガラス抽出物を含有することで、爪の生え際や指先及び、足裏のケアにおいてより効果的な甘皮除去及び皮膚軟化性能を発揮することができる。 (Content of bioactive glass extract)
In this embodiment, the content of the bioactive glass extract is 30% by weight or more, preferably 40% by weight or more, more preferably 50% by weight or more based on 100% by weight of the cuticle remover. preferable. By containing a sufficient amount of the bioactive glass extract, more effective cuticle removal and emollient performance can be exhibited in the care of the hairline, fingertips and soles of nails.
＜角質軟化組成物の使用方法＞
　その他、本発明の角質軟化組成物は、従来の角質軟化剤にはない下記のような効果を発揮することができる。
１．皮膚の赤みを抑制する効果
　生体活性ガラスからの抽出物を含むことにより、紫外線処理や化学皮膚バリアの損傷によって生じる赤みが抑えられること等が明らかになっている。
２．しわを目立たなくする効果
　生体活性ガラスからの抽出物を含むことにより、短期間でしわの長さと深さが目に見える形で大幅に減少することが明らかになっている。
３．抗酸化効果
　生体活性ガラスからの抽出物を含むことにより、生体外タンパク質カルボニルアッセイやその他の試験環境において明確な抗酸化効果を発揮することが明らかになっている。 <Method of using keratin softening composition>
In addition, the keratin softening composition of the present invention can exhibit the following effects not found in conventional keratin softeners.
1. Effect of suppressing skin redness It has been clarified that by including an extract from bioactive glass, redness caused by ultraviolet treatment or damage to a chemical skin barrier is suppressed.
2. Effect of making wrinkles less noticeable Including an extract from bioactive glass has been shown to significantly reduce the length and depth of wrinkles in a short period of time in a visible way.
3. Antioxidant Effect The inclusion of extracts from bioactive glass has been shown to exert distinct antioxidant effects in in vitro protein carbonyl assays and other test environments.
　本発明の角質軟化組成物は、爪の生え際や指先及び、足裏のケアにおいてより効果的な甘皮除去及び皮膚軟化性能を有するものである。本発明の角質軟化組成物は、いわゆるキューティクルリムーバーに好適である。上述したキューティクルリムーバーを甘皮及び甘皮周辺の皮膚に室温で適用し、３０秒間以上放置後に甘皮除去又は爪根元への押し上げを行う。 角 The keratin softening composition of the present invention has more effective cuticle removal and skin softening performance in the care of the hairline of the nail, fingertips and soles. The keratin softening composition of the present invention is suitable for a so-called cuticle remover. The above-mentioned cuticle remover is applied to the cuticle and the skin around the cuticle at room temperature, and after leaving for at least 30 seconds, cuticle is removed or pushed up to the base of the nail.
　本実施形態に記載の発明によると、日用品の石鹸水やアルカリ温泉と同等のｐＨであっても、角質軟化組成物を皮膚に適用し、室温で３０秒間放置するだけで、甘皮の軟化効果を得ることができる。 According to the invention described in the present embodiment, even if the pH is the same as that of soap water or alkaline hot spring of daily necessities, the keratin softening composition is applied to the skin and left at room temperature for 30 seconds to reduce the softening effect of cuticle. Obtainable.
　図１は、本発明の一実施形態にかかる角質軟化組成物の（ａ）使用前と（ｂ）使用後の爪周辺の角質の様子を比較した図である。
　図１の（ａ）使用前の図に示すように、主に丸枠で囲った部位において、甘皮が付着していることが観察できる。図１の（ｂ）使用後の図に示すように、この爪に対して本発明の角質軟化組成物を使用すると、甘皮をきれいに除去することができている。 FIG. 1 is a diagram comparing the state of keratin around the nail after (a) use and (b) after use of the keratin softening composition according to one embodiment of the present invention.
As shown in FIG. 1 (a) before use, it can be observed that the cuticle is attached mainly at the site surrounded by the round frame. As shown in the figure after use of FIG. 1 (b), when the keratin softening composition of the present invention is used for this nail, the cuticle can be removed cleanly.
　図２は、本発明の一実施形態にかかる角質軟化組成物の（ａ）使用前と（ｂ）使用後の足裏（かかと）周辺の角質の様子を比較した図である。
　図２の（ａ）使用前の図に示すように、かかとの表面の角質が白く溝状に（ひび割れ）なっていることが観察できる。図２の（ｂ）使用後の図に示すように、このかかとに対して本発明の角質軟化組成物を使用すると、白い溝状のひび割れを除去することができている。 FIG. 2 is a diagram comparing the keratin conditions around the sole (heel) before (a) use and (b) after use of the keratin softening composition according to one embodiment of the present invention.
As shown in FIG. 2 (a) before use, it can be observed that the keratin on the surface of the heel is white and grooved (cracked). As shown in FIG. 2 (b) after use, when the keratin softening composition of the present invention is used for the heel, white groove-like cracks can be removed.
　以下、具体例を挙げて本発明を更に詳細に説明するが、これらの実施例は本発明の技術的範囲を何ら限定するものではない。 Hereinafter, the present invention will be described in more detail with reference to specific examples, but these examples do not limit the technical scope of the present invention at all.
＜試験１＞　ｐＨによる比較試験
［本発明に使用した原材料］
１．生体活性ガラス　ＳＣＨＯＴＴ社「Ｖｉｔｒｙｘｘ（登録商標）」粉末状、平均粒子径２．０μｍ
２．蒸留水
３．湿潤剤・保湿剤　ポリエチレングリコール６００（略号：ＰＥＧ６００）、グリセリン
４．無水エタノール
５．増粘剤　クラリアントジャパン社「アリストフレックスＨＭＢ」 <Test 1> Comparative test by pH [Raw materials used in the present invention]
1. Bioactive glass SCHOTT “Vitryxx (registered trademark)” powder, average particle size 2.0 μm
2. Distilled water3. 3. Wetting agent / humectant Polyethylene glycol 600 (abbreviation: PEG 600), glycerin Absolute ethanol5. Thickener Clariant Japan, Inc. "Aristoflex HMB"
［生体活性ガラス抽出物の製造］
　生体活性ガラス抽出物Ａ：蒸留水９８重量％、生体活性ガラス（Ｖｉｔｒｙｘｘ）２重量％からなる混合物１０００ｇをガラス瓶に調製し、２４時間震盪させた後、１時間以上静置し生体活性ガラスを沈殿させた。次いで、親水性ＰＴＦＥフィルター（細孔径：０．５μｍ）を使用して上澄み液を吸引濾過し、生体活性ガラス抽出物を製造した。 [Production of bioactive glass extract]
Bioactive glass extract A: 1000 g of a mixture consisting of 98% by weight of distilled water and 2% by weight of bioactive glass (Vitryxx) is prepared in a glass bottle, shaken for 24 hours, and allowed to stand for 1 hour or more to precipitate the bioactive glass. I let it. Subsequently, the supernatant was suction-filtered using a hydrophilic PTFE filter (pore diameter: 0.5 μm) to produce a bioactive glass extract.
　生体活性ガラス抽出物Ｂ：蒸留水９６重量％、生体活性ガラス（Ｖｉｔｒｙｘｘ）４重量％からなる混合物１０００ｇをガラス瓶に調製し、２４時間震盪させた後、１時間以上静置し生体活性ガラスを沈殿させた。次いで、親水性ＰＴＦＥフィルター（細孔径：０．５μｍ）を使用して上澄み液を吸引濾過し、生体活性ガラス抽出物を製造した。 Bioactive glass extract B: 1000 g of a mixture consisting of 96% by weight of distilled water and 4% by weight of bioactive glass (Vitryxx) is prepared in a glass bottle, shaken for 24 hours, and allowed to stand for 1 hour or more to precipitate the bioactive glass. I let it. Subsequently, the supernatant was suction-filtered using a hydrophilic PTFE filter (pore diameter: 0.5 μm) to produce a bioactive glass extract.
［角質軟化組成物の製造及び評価］
　以下の実施例、比較例及び参考例の角質軟化組成物は、ｐＨが９～１１程度の弱アルカリ性になっている。 [Production and evaluation of keratin softening composition]
The keratin softening compositions of the following Examples, Comparative Examples and Reference Examples are slightly alkaline, having a pH of about 9 to 11.
Figure JPOXMLDOC01-appb-T000001
Figure JPOXMLDOC01-appb-T000001
Figure JPOXMLDOC01-appb-T000002
Figure JPOXMLDOC01-appb-T000002
［参考例１、比較例１］
　表１、２記載の配合表１、２に従って、各成分を計量し震盪混合し、角質軟化組成物を得た。 [Reference Example 1, Comparative Example 1]
According to Formulation Tables 1 and 2 described in Tables 1 and 2, each component was weighed and mixed by shaking to obtain a softening composition.
［参考例２，３、実施例４－６、比較例２－６］
　表１、２記載の配合表１、２に従って、各成分を計量しホモミキサーを使用して液温６０℃で６時間混合し角質軟化組成物を得た。 [Reference Examples 2 and 3, Example 4-6, Comparative Example 2-6]
According to Formulation Tables 1 and 2 described in Tables 1 and 2, each component was weighed and mixed at a liquid temperature of 60 ° C. for 6 hours using a homomixer to obtain a keratin softening composition.
　実施例４－６及び比較例４－６の角質軟化組成物をＰＥ性ボトル容器（２０ｍＬ、中栓ノズル容器）に充填し、手指及び足指の爪根元に生じる甘皮処理用化粧料として使用した。実施例４－６の角質軟化組成物を甘皮及び甘皮周辺の皮膚に適用し、３０秒間放置後に甘皮除去又は爪根元への押し上げを実施した結果、短時間で甘皮が軟化されており容易に除去又は爪根元への押し上げが可能であった。一方、比較例４－６の角質軟化組成物は、適用後３０秒間及び６０秒間放置しても甘皮及び皮膚角質の軟化は認められなかった。 The keratin softening compositions of Example 4-6 and Comparative Example 4-6 were filled in a PE bottle container (20 mL, inner stopper nozzle container), and used as a cosmetic for cuticle treatment generated at the base of nails of fingers and toes. . The keratin softening composition of Example 4-6 was applied to the cuticle and the skin around the cuticle, and after leaving for 30 seconds, the cuticle was removed or pushed up to the base of the nail. As a result, the cuticle was softened in a short time and easily removed. Or it was possible to push up to the base of the nail. On the other hand, the keratin softening composition of Comparative Example 4-6 showed no cuticle or keratin softening even after being left for 30 seconds and 60 seconds after application.
　参考例１－３及び比較例１－３の角質軟化組成物をＰＥ性ボトル容器（２０ｍＬ、スプレータイプ容器）に充填し、足裏及びかかとの角質除去用化粧料として使用した。参考例１－３の角質軟化組成物を足裏及びかかとに噴霧し、３０秒間放置後に足裏及びかかとの角質をフットファイル（足裏用やすり）にて除去した結果、短時間で角質が軟化されており容易に除去可能であった。一方で、比較例１－３の角質軟化組成物は、適用後３０秒間及び６０秒間放置しても角質の軟化は認められなかった。 角 The keratin softening compositions of Reference Example 1-3 and Comparative Example 1-3 were filled in a PE bottle (20 mL, spray type container) and used as a cosmetic for removing keratin of soles and heels. The keratin softening composition of Reference Example 1-3 was sprayed on the sole and the heel, and after standing for 30 seconds, the keratin of the sole and the heel was removed with a foot file (file for the sole). And was easily removable. On the other hand, the keratin softening composition of Comparative Example 1-3 did not show keratin softening even after being left for 30 seconds and 60 seconds after application.
Figure JPOXMLDOC01-appb-T000003
Figure JPOXMLDOC01-appb-T000003
Figure JPOXMLDOC01-appb-T000004
Figure JPOXMLDOC01-appb-T000004
［参考例７、比較例７］
　表３、４記載の配合表３、４に従って、各成分を計量し震盪混合し、角質軟化組成物を得た。
［参考例８、実施例９－１２、比較例８－１２］
　表３、４記載の配合表３、４に従って、各成分を計量しホモミキサーを使用して液温６０℃で６時間混合し角質軟化組成物を得た。 [Reference Example 7, Comparative Example 7]
According to Formulation Tables 3 and 4 described in Tables 3 and 4, each component was weighed and mixed by shaking to obtain a keratin softening composition.
[Reference Example 8, Example 9-12, Comparative Example 8-12]
According to Formulation Tables 3 and 4 described in Tables 3 and 4, each component was weighed and mixed at a liquid temperature of 60 ° C. for 6 hours using a homomixer to obtain a keratin softening composition.
　実施例１０－１２及び比較例１０－１２の角質軟化組成物をＰＥ性ボトル容器（２０ｍＬ、中栓ノズル容器）に充填し、手指及び足指の爪根元に生じる甘皮処理用化粧料として使用した。実施例１０－１２の角質軟化組成物を甘皮及び甘皮周辺の皮膚に適用し、３０秒間放置後に甘皮除去又は爪根元への押し上げを実施した結果、短時間で甘皮が軟化されており容易に除去又は爪根元への押し上げが可能であった。一方、比較例１０－１２の角質軟化組成物は、適用後３０秒間及び６０秒間放置しても甘皮及び皮膚角質の軟化は認められなかった。 The keratin softening compositions of Example 10-12 and Comparative Example 10-12 were filled into PE bottle containers (20 mL, inner stopper nozzle containers), and used as cosmetics for cuticle treatment generated at the base of nails of fingers and toes. . The keratin softening composition of Examples 10-12 was applied to the cuticle and the skin around the cuticle, and after leaving for 30 seconds, the cuticle was removed or pushed up to the base of the nail. As a result, the cuticle was softened in a short time and easily removed. Or it was possible to push up to the base of the nail. On the other hand, the keratin softening compositions of Comparative Examples 10-12 showed no cuticle or keratin softening even after standing for 30 seconds and 60 seconds after application.
　参考例７，８、実施例９及び比較例７－９の角質軟化組成物をＰＥ性ボトル容器（２０ｍＬ、スプレータイプ容器）に充填し、足裏及びかかとの角質除去用化粧料として使用した。参考例７，８、実施例９の角質軟化組成物を足裏及びかかとに噴霧し、３０秒間放置後に足裏及びかかとの角質をフットファイル（足裏用やすり）にて除去した結果、短時間で角質が軟化されており容易に除去可能であった。一方で、比較例７－９の角質軟化組成物は、適用後３０秒間及び６０秒間放置しても角質の軟化は認められなかった。 角 The keratin softening compositions of Reference Examples 7 and 8, Example 9 and Comparative Examples 7-9 were filled in PE bottle containers (20 mL, spray type container) and used as cosmetics for removing keratin of soles and heels. The keratin softening compositions of Reference Examples 7, 8 and 9 were sprayed on the soles and heels, and after standing for 30 seconds, the keratins of the soles and heels were removed with a foot file (file for soles). The keratin was softened and could be easily removed. On the other hand, the keratin softening compositions of Comparative Examples 7-9 did not show keratin softening even after being left for 30 seconds and 60 seconds after application.
Figure JPOXMLDOC01-appb-T000005
Figure JPOXMLDOC01-appb-T000005
Figure JPOXMLDOC01-appb-T000006
Figure JPOXMLDOC01-appb-T000006
Figure JPOXMLDOC01-appb-T000007
Figure JPOXMLDOC01-appb-T000007
［参考例１３、１９］
　表５、６記載の配合表５、６に従って、各成分を計量し震盪混合し、角質軟化組成物を得た。 [Reference Examples 13 and 19]
According to Formulation Tables 5 and 6 described in Tables 5 and 6, each component was weighed and mixed by shaking to obtain a keratin softening composition.
［参考例１４，１５、実施例１６－１８、参考例１９－２１、実施例２２－２７、参考例２８、実施例２９、参考例３０］
　表５、６、７記載の配合表５、６、７に従って、各成分を計量しホモミキサーを使用して液温６０℃で６時間混合し角質軟化組成物を得た。 [Reference Examples 14 and 15, Examples 16-18, Reference Examples 19-21, Examples 22-27, Reference Examples 28, 29 and Reference Examples 30]
According to Formulation Tables 5, 6, and 7 described in Tables 5, 6, and 7, the respective components were weighed and mixed at a liquid temperature of 60 ° C. for 6 hours using a homomixer to obtain a keratin softening composition.
　実施例１６－１８、２２－２７、参考例２８、実施例２９、参考例３０の角質軟化組成物をＰＥ性ボトル容器（２０ｍＬ、中栓ノズル容器）に充填し、手指及び足指の爪根元に生じる甘皮処理用化粧料として使用した。実施例１６－１８、実施例２２－２７、参考例２８、実施例２９、参考例３０の角質軟化組成物を甘皮及び甘皮周辺の皮膚に適用し、３０秒間放置後に甘皮除去又は爪根元への押し上げを実施した結果、短時間で甘皮が軟化されており容易に除去又は爪根元への押し上げが可能であった。 The keratin softening compositions of Examples 16-18, 22-27, Reference Example 28, Example 29, and Reference Example 30 were filled in PE bottle containers (20 mL, inner stopper nozzle containers), and the bases of the fingers and toenails were caught. This was used as a cuticle treatment cosmetic. The keratin softening compositions of Examples 16-18, Examples 22-27, Reference Examples 28, 29 and Reference Example 30 are applied to cuticles and skin around the cuticles, and after leaving for 30 seconds, cuticles are removed or applied to the base of nails. As a result of pushing up, the cuticle was softened in a short time, and it could be easily removed or pushed up to the base of the nail.
　参考例１３－１５、１９－２１の角質軟化組成物をＰＥ性ボトル容器（２０ｍＬ、スプレータイプ容器）に充填し、足裏及びかかとの角質除去用化粧料として使用した。参考例１３－１５、１９－２１の角質軟化組成物を足裏及びかかとに噴霧し、３０秒間放置後に足裏及びかかとの角質をフットファイル（足裏用やすり）にて除去した結果、短時間で角質が軟化されており容易に除去可能であった。 角 The keratin softening compositions of Reference Examples 13-15 and 19-21 were filled in a PE bottle (20 mL, spray type container) and used as a cosmetic for removing keratin on soles and heels. The keratin softening compositions of Reference Examples 13-15 and 19-21 were sprayed on the soles and heels, and after standing for 30 seconds, the keratins on the soles and heels were removed with a foot file (file for the soles). The keratin was softened and could be easily removed.
Figure JPOXMLDOC01-appb-T000008
Figure JPOXMLDOC01-appb-T000008
［参考例３１－３６］
　表８記載の配合表８に従って、各成分を計量し震盪混合し、角質軟化組成物を得た。 [Reference Examples 31-36]
According to Formulation Table 8 shown in Table 8, each component was weighed and mixed by shaking to obtain a keratin softening composition.
　参考例３１－３６の角質軟化組成物をＰＥ性ボトル容器（２０ｍＬ、中栓ノズル容器）に充填し、手指及び足指の爪根元に生じる甘皮処理用化粧料として使用した。参考例３１－３６の角質軟化組成物を甘皮及び甘皮周辺の皮膚に適用し、３０秒間放置後に甘皮除去又は爪根元への押し上げを実施した結果、短時間で甘皮が軟化されており容易に除去又は爪根元への押し上げが可能であった。さらに、参考例３１－３６の角質軟化組成物をＰＥ性ボトル容器（２０ｍＬ、スプレータイプ容器）に充填し、足裏及びかかとの角質除去用化粧料として使用した。参考例３１－３６の角質軟化組成物を足裏及びかかとに噴霧し、３０秒間放置後に足裏及びかかとの角質をフットファイル（足裏用やすり）にて除去した結果、短時間で角質が軟化されており容易に除去可能であった。 角 The keratin softening composition of Reference Examples 31 to 36 was filled in a PE bottle container (20 mL, inner stopper nozzle container) and used as a cuticle treatment cosmetic formed at the base of the finger and toe nails. The keratin softening composition of Reference Examples 31-36 was applied to cuticle and the skin around the cuticle, and after leaving for 30 seconds, the cuticle was removed or pushed up to the base of the nail. As a result, the cuticle was softened in a short time and easily removed. Or it was possible to push up to the base of the nail. Further, the keratin softening composition of Reference Examples 31 to 36 was filled in a PE bottle (20 mL, spray type container) and used as a cosmetic for removing keratin of soles and heels. The keratin softening composition of Reference Examples 31-36 was sprayed on the soles and heels, and after standing for 30 seconds, the keratins on the soles and heels were removed with a foot file (file for soles). And was easily removable.
Figure JPOXMLDOC01-appb-T000009
Figure JPOXMLDOC01-appb-T000009
Figure JPOXMLDOC01-appb-T000010
Figure JPOXMLDOC01-appb-T000010
Figure JPOXMLDOC01-appb-T000011
Figure JPOXMLDOC01-appb-T000011
［実施例３７－４４、参考例４５、実施例４６、参考例４７、実施例４８、比較例１３－１８］
　表９－１１記載の配合表９－１１に従って、各成分を計量しホモミキサーを使用して液温６０℃で６時間混合し角質軟化組成物を得た。 [Examples 37-44, Reference Example 45, Example 46, Reference Example 47, Example 48, Comparative Examples 13-18]
According to the composition table 9-11 described in Table 9-11, each component was weighed and mixed at a liquid temperature of 60 ° C. for 6 hours using a homomixer to obtain a keratin softening composition.
　実施例３７－４４、参考例４５、実施例４６、参考例４７、実施例４８、比較例１３－１８の角質軟化組成物をＰＥ性ボトル容器（２０ｍＬ、中栓ノズル容器）に充填し、手指及び足指の爪根元に生じる甘皮処理用化粧料として使用した。実施例３７－４４、参考例４５、実施例４６、参考例４７、実施例４８の角質軟化組成物を甘皮及び甘皮周辺の皮膚に適用し、３０秒間放置後に甘皮除去又は爪根元への押し上げを実施した結果、短時間で甘皮が軟化されており容易に除去又は爪根元への押し上げが可能であった。一方、比較例１３－１８の角質軟化組成物は、適用後３０秒間及び６０秒間放置しても甘皮及び皮膚角質の軟化は認められなかった。 Each of the keratin softening compositions of Examples 37-44, Reference Example 45, Example 46, Reference Example 47, Example 48, and Comparative Examples 13-18 was filled into a PE bottle (20 mL, inner plug nozzle container), It was used as a cosmetic for cuticle treatment generated at the base of the toenails. The keratin softening compositions of Examples 37-44, Reference Example 45, Example 46, Reference Example 47, and Example 48 were applied to cuticle and the skin around the cuticle, and after leaving for 30 seconds, the cuticle was removed or pushed up to the base of the nail. As a result, the cuticle was softened in a short time, and it could be easily removed or pushed up to the base of the nail. On the other hand, in the keratin softening compositions of Comparative Examples 13-18, even after leaving for 30 seconds and 60 seconds after application, no softening of cuticle and keratin was observed.
＜試験２＞　生体活性ガラス抽出物による角質軟化効果の再確認
　生体活性ガラス抽出物による角質軟化効果の再確認を目的として、市販アルカリ性液体を主成分とする組成物と、生体活性ガラス抽出物Ａを主成分とする組成物による、使用感の差異について検討した。 <Test 2> Reconfirmation of the keratin softening effect of the bioactive glass extract For the purpose of reconfirming the keratin softening effect of the bioactive glass extract, a composition containing a commercially available alkaline liquid as a main component and a bioactive glass extract A The difference in the feeling of use due to the composition containing as a main component was examined.
〔角質軟化組成物の配合表〕
Figure JPOXMLDOC01-appb-T000012
 (Composition table of keratin softening composition)
Figure JPOXMLDOC01-appb-T000012
〔使用感の確認方法〕
　実施例５、組成物１をＰＥ性ボトル容器（２０ｍＬ、中栓ノズル容器）に充填し、手指及び足指の爪根元に生じる甘皮処理用化粧料として使用した。実施例５、組成物１を甘皮及び甘皮周辺の皮膚に適用し、３０秒間放置後に甘皮除去又は爪根元への押し上げを行った。 [Confirmation of usability]
Example 5 Composition 1 was filled in a PE bottle container (20 mL, inner stopper nozzle container), and used as a cuticle treatment cosmetic formed at the base of the finger and toe nails. Example 5 The composition 1 was applied to cuticle and the skin around the cuticle, and after leaving for 30 seconds, cuticle was removed or pushed up to the base of the nail.
〔結果〕
　各項目に対して、５段階評価（評価５～評価１）を行い、施術操作上の状況について記載した。結果を表１３に示す。
　なお、評価５が品質に優れていることを示し、数値が下がるにつれて品質が劣り、評価１が最も劣っていることを示す。
Figure JPOXMLDOC01-appb-T000013
 〔result〕
Each item was evaluated on a 5-point scale (Evaluation 5 to Evaluation 1), and the status of the operation was described. Table 13 shows the results.
In addition, the evaluation 5 shows that the quality is excellent, and the lower the numerical value is, the lower the quality is, and the evaluation 1 is the lowest.
Figure JPOXMLDOC01-appb-T000013
　本試験により、生体活性ガラス抽出物を主成分とする組成物は、生体活性ガラス抽出物を主成分としない同等のｐＨの組成物に比べて使用感に優れることが確認された。 This test confirmed that the composition containing a bioactive glass extract as a main component was superior in use feeling to a composition having an equivalent pH not containing a bioactive glass extract as a main component.

Claims (4)

  1. 　キューティクルリムーバーであって、
    　生体活性ガラス２重量％～５０重量％と水系溶媒９８重量％～５０重量％とを含有する生体活性ガラス含有液から前記生体活性ガラスが除去されることによって得られた生体活性ガラス抽出物を含有し、
    　前記生体活性ガラス抽出物の含有量がキューティクルリムーバー１００重量％に対して３０重量％以上であり、
    　ｐＨが８以上１０以下である、キューティクルリムーバー。     A cuticle remover,
    Contains a bioactive glass extract obtained by removing the bioactive glass from a bioactive glass-containing liquid containing 2% to 50% by weight of the bioactive glass and 98% to 50% by weight of an aqueous solvent. And
    The content of the bioactive glass extract is 30% by weight or more based on 100% by weight of the cuticle remover;
    A cuticle remover having a pH of 8 or more and 10 or less.
  2. 　保湿剤及び増粘剤をさらに含有する、請求項１に記載のキューティクルリムーバー。 The cuticle remover according to claim 1, further comprising a humectant and a thickener.
  3. 　２重量％～５０重量％の生体活性ガラスを、１分以上１００，０００時間以下の間、９８重量％～５０重量％の水系溶媒中で混合して、生体活性ガラス、及び前記生体活性ガラスからの抽出物を含む角質軟化前駆組成物を生成する抽出ステップと、
    　前記角質軟化前駆組成物をろ過して前記生体活性ガラスを除去し、ｐＨを８以上１０以下に調整して、前記抽出物からなるキューティクルリムーバーを生成するろ過ステップと、
    　を含み、
    　前記抽出物の含有量がキューティクルリムーバー１００重量％に対して３０重量％以上である、キューティクルリムーバーの製造方法。     2% to 50% by weight of the bioactive glass is mixed in an aqueous solvent of 98% to 50% by weight for 1 minute or more and 100,000 hours or less to form the bioactive glass and the bioactive glass. Extracting to produce a keratin softening precursor composition comprising an extract of
    A filtration step of filtering the keratin softening precursor composition to remove the bioactive glass, adjusting the pH to 8 or more and 10 or less, and producing a cuticle remover comprising the extract;
    Including
    A method for producing a cuticle remover, wherein the content of the extract is 30% by weight or more based on 100% by weight of the cuticle remover.
  4. 　請求項１又は２に記載のキューティクルリムーバーを甘皮及び甘皮周辺の皮膚に室温で適用し、３０秒間以上放置後に甘皮除去又は爪根元への押し上げを行う、キューティクルリムーバーの使用方法。 A method of using a cuticle remover, wherein the cuticle remover according to claim 1 or 2 is applied to cuticles and skin around the cuticles at room temperature, and left for at least 30 seconds to remove cuticles or push up to the base of nails.
PCT/JP2019/028563 2018-09-18 2019-07-19 Cuticle remover, method for producing same, use thereof WO2020059283A1 (en)

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JP2018173195A JP6558713B1 (en) 2018-09-18 2018-09-18 Keratin softening composition
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JP6925072B1 (en) * 2020-12-07 2021-08-25 株式会社Ｄｒ．Ｃｈｅｒｒｙ Composition for hair improvement
JP7096959B1 (en) 2021-02-02 2022-07-07 有限会社ル・グランクール How to promote the growth of your own nails

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JP2001302430A (en) * 2000-04-20 2001-10-31 Kyodo:Kk Face lotion and method for producing the same
JP2002535261A (en) * 1999-01-20 2002-10-22 ユーエスバイオマテリアルズ コーポレイション Compositions and methods for treating nails and adjacent tissues
JP2004500404A (en) * 2000-03-27 2004-01-08 カール　−　ツァイス　−　シュティフツング Novel cosmetic, body care, cleansing and nutritional supplement compositions containing bioactive glass and methods of manufacture and use thereof
JP2006052154A (en) * 2004-08-10 2006-02-23 Bcs Inc Nail-care composition
JP2007507426A (en) * 2003-09-29 2007-03-29 ショット アクチエンゲゼルシャフト Tissue abrasive
US20120052029A1 (en) * 2009-08-21 2012-03-01 Busch Francis W Methods and substances for strengthening and conditioning human fingernails and toe nails

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Publication number Priority date Publication date Assignee Title
JP2002535261A (en) * 1999-01-20 2002-10-22 ユーエスバイオマテリアルズ コーポレイション Compositions and methods for treating nails and adjacent tissues
JP2004500404A (en) * 2000-03-27 2004-01-08 カール　−　ツァイス　−　シュティフツング Novel cosmetic, body care, cleansing and nutritional supplement compositions containing bioactive glass and methods of manufacture and use thereof
JP2001302430A (en) * 2000-04-20 2001-10-31 Kyodo:Kk Face lotion and method for producing the same
JP2007507426A (en) * 2003-09-29 2007-03-29 ショット アクチエンゲゼルシャフト Tissue abrasive
JP2006052154A (en) * 2004-08-10 2006-02-23 Bcs Inc Nail-care composition
US20120052029A1 (en) * 2009-08-21 2012-03-01 Busch Francis W Methods and substances for strengthening and conditioning human fingernails and toe nails

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