WO2020013781A3 - Synergistic effect of flurbiprofen and a gastro protective agent for the treatment of pain and inflammation - Google Patents
Synergistic effect of flurbiprofen and a gastro protective agent for the treatment of pain and inflammation Download PDFInfo
- Publication number
- WO2020013781A3 WO2020013781A3 PCT/TR2019/050200 TR2019050200W WO2020013781A3 WO 2020013781 A3 WO2020013781 A3 WO 2020013781A3 TR 2019050200 W TR2019050200 W TR 2019050200W WO 2020013781 A3 WO2020013781 A3 WO 2020013781A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- flurbiprofen
- protective agent
- inflammation
- pain
- treatment
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/10—Carbonates; Bicarbonates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The present invention relates to an oral immediate release pharmaceutical composition in a single unit dosage form comprising flurbiprofen or a pharmaceutically acceptable salt thereof and a H2 receptor antagonist as a gastro protective agent, wherein H2 receptor antagonist is present in an amount of from 5 to 80% by weight of flurbiprofen. The present invention is also about an oral immediate release pharmaceutical composition in a single unit dosage form comprising flurbiprofen or a pharmaceutically acceptable salt thereof, an H2 receptor antagonist, or a pharmaceutically acceptable salt thereof, and a carbonate wherein the H2 receptor antagonist is present in an amount between 10 and 80% by weight based on the weight of flurbiprofen.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
TR2018/04315 | 2018-03-27 | ||
TR201804315 | 2018-03-27 | ||
TR2018/05998 | 2018-04-27 | ||
TR201805998 | 2018-04-27 | ||
TR201807777 | 2018-05-31 | ||
TR2018/07777 | 2018-05-31 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2020013781A2 WO2020013781A2 (en) | 2020-01-16 |
WO2020013781A3 true WO2020013781A3 (en) | 2020-03-19 |
Family
ID=68887105
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/TR2019/050200 WO2020013781A2 (en) | 2018-03-27 | 2019-03-27 | Synergistic effect of flurbiprofen and a gastro protective agent for the treatment of pain and inflammation |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2020013781A2 (en) |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6194003B1 (en) * | 1997-05-22 | 2001-02-27 | The Boots Company Plc | Process for making flurbiprofen lozenges |
US20030069255A1 (en) * | 2001-06-01 | 2003-04-10 | Pozen Inc. | Pharmaceutical compositions for the coordinated delivery of NSAIDs |
EP2682109A1 (en) * | 2012-07-05 | 2014-01-08 | Sanovel Ilac Sanayi ve Ticaret A.S. | Combined immediate release formulations of flurbiprofen and famotidine |
US20150290174A1 (en) * | 2014-04-11 | 2015-10-15 | Resuscitate MOE LLC | Pharmaceutical formulations and method of using the same for alleviating symptoms of hangover, stomach flu or migraine |
US20180008712A1 (en) * | 2014-12-25 | 2018-01-11 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Oral topical aqueous pharmaceutical compositions of flurbiprofen and dexpanthenol |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998002182A1 (en) | 1996-07-12 | 1998-01-22 | Novartis Consumer Health S.A. | Oral pharmaceutical combinations of nsaids with terpenoids |
US20050163847A1 (en) | 2004-01-21 | 2005-07-28 | Andrx Pharmaceuticals, Llc | Pharmaceutical formulations containing a non-steroidal antiinflammatory drug and an antiulcerative drug |
US8067033B2 (en) | 2007-11-30 | 2011-11-29 | Horizon Pharma Usa, Inc. | Stable compositions of famotidine and ibuprofen |
US8569375B2 (en) | 2008-08-22 | 2013-10-29 | Reckitt Benckiser Healthcare (Uk) Limited | Compositions |
DE102012209150B3 (en) | 2012-05-31 | 2013-04-11 | Siemens Aktiengesellschaft | Adaptive X-ray filter for altering local intensity of X-ray radiation applied to patient, has electrically deformable position element to change layer thickness of X-ray radiation absorbing liquid by displacing absorbing liquid |
-
2019
- 2019-03-27 WO PCT/TR2019/050200 patent/WO2020013781A2/en active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6194003B1 (en) * | 1997-05-22 | 2001-02-27 | The Boots Company Plc | Process for making flurbiprofen lozenges |
US20030069255A1 (en) * | 2001-06-01 | 2003-04-10 | Pozen Inc. | Pharmaceutical compositions for the coordinated delivery of NSAIDs |
EP2682109A1 (en) * | 2012-07-05 | 2014-01-08 | Sanovel Ilac Sanayi ve Ticaret A.S. | Combined immediate release formulations of flurbiprofen and famotidine |
US20150290174A1 (en) * | 2014-04-11 | 2015-10-15 | Resuscitate MOE LLC | Pharmaceutical formulations and method of using the same for alleviating symptoms of hangover, stomach flu or migraine |
US20180008712A1 (en) * | 2014-12-25 | 2018-01-11 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Oral topical aqueous pharmaceutical compositions of flurbiprofen and dexpanthenol |
Also Published As
Publication number | Publication date |
---|---|
WO2020013781A2 (en) | 2020-01-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA201270221A1 (en) | TREATMENT OF CROWN DISEASE WITH LACQUINIMODE | |
HRP20150644T1 (en) | Method of treating atrial fibrillation | |
NZ605887A (en) | Pharmaceutical dosage form comprising 6’-fluoro-(n-methyl- or n,n-dimethyl-)-4-phenyl-4’,9’-dihydro-3’h-spiro[cyclohexane-1,1’-pyrano[3,4,b]indol]-4-amine for the treatment of neuropathic pain | |
WO2012079092A3 (en) | Testosterone undecanoate compositions | |
NZ587202A (en) | Methods for measuring a patient response upon administration of a drug and compositions thereof | |
NZ605469A (en) | Nalbuphine-based formulations and uses thereof | |
MX2010003923A (en) | Pharmaceutical formulation of valsartan. | |
MX354423B (en) | Extended release formulations of rasagiline and uses thereof. | |
EP2493312A4 (en) | Solid pharmaceutical compositions containing an integrase inhibitor | |
PT2205279E (en) | Pharmaceutical combination of aliskiren and valsartan | |
MX2022015629A (en) | Use of vibegron to treat overactive bladder. | |
MX2021014774A (en) | Modified release formulations and uses thereof. | |
WO2018027084A3 (en) | Combination of glucagon receptor antagonists and pi3k pathway inhibitors for the treatment of cancer | |
TW200603816A (en) | Risedronate compositions and their methods of use | |
WO2008008882A3 (en) | Glucocorticoid receptor modulator and methods of use | |
JP2016505050A5 (en) | ||
MX2021008208A (en) | Tesofensine for reduction of body weight in prader-willi patients. | |
MX341660B (en) | Ghrelin receptor agonist for treatment of dyscrasia. | |
MX2013002649A (en) | Therapeutic agent for pain. | |
RU2016137926A (en) | GRAPHIPRANT COMPOSITIONS AND WAYS OF THEIR APPLICATION | |
WO2020013776A3 (en) | Synergistic effect of naproxen and a gastro protective agent for the treatment of pain and inflammation | |
WO2020013781A3 (en) | Synergistic effect of flurbiprofen and a gastro protective agent for the treatment of pain and inflammation | |
WO2020032883A3 (en) | Synergistic effects of a novel ketoprofen formulation including a gastro protective agent | |
WO2019203759A3 (en) | Combinations of etodolac with h2 receptor antagonists for the treatment of pain and inflammation. | |
JP2012097034A5 (en) |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
32PN | Ep: public notification in the ep bulletin as address of the adressee cannot be established |
Free format text: NOTING OF LOSS OF RIGHTS PURSUANT TO RULE 112(1) EPC (EPO FORM 1205A DATED 26.01.2021) |
|
122 | Ep: pct application non-entry in european phase |
Ref document number: 19820911 Country of ref document: EP Kind code of ref document: A2 |