WO2019148932A1 - 一种中药造口胶盘配方及其制作方法 - Google Patents

一种中药造口胶盘配方及其制作方法 Download PDF

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Publication number
WO2019148932A1
WO2019148932A1 PCT/CN2018/114928 CN2018114928W WO2019148932A1 WO 2019148932 A1 WO2019148932 A1 WO 2019148932A1 CN 2018114928 W CN2018114928 W CN 2018114928W WO 2019148932 A1 WO2019148932 A1 WO 2019148932A1
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parts
chinese medicine
traditional chinese
temperature
stoma
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PCT/CN2018/114928
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English (en)
French (fr)
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夏峰
冯幼强
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振德医疗用品股份有限公司
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Publication of WO2019148932A1 publication Critical patent/WO2019148932A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/0005—Ingredients of undetermined constitution or reaction products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L28/00—Materials for colostomy devices
    • A61L28/003—Ingredients of undetermined constitution or reaction products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/08—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/104—Gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures

Definitions

  • the invention relates to a traditional Chinese medicine ostomy plastic disc formula and a preparation method thereof, and belongs to the technical field of ostomy medical treatment.
  • “Stomatology” is caused by diseases of the digestive system or urinary system. It is necessary to separate the intestine by surgical treatment, and one end of the intestine is taken out to the body surface (the anus or the urethra is moved to the abdominal wall) to form an opening. It can achieve intestinal decompression, reduce obstruction, protect the anastomosis or injury of the distal intestine, promote the recovery of intestinal and urinary tract diseases, and even save the lives of patients.
  • the stoma is generally aimed at rectal and bladder lesions (such as rectal cancer, bladder cancer, intestinal obstruction, etc.).
  • rectal cancer will remove the rectum and anal canal, and the bladder cancer will be removed.
  • the bladder then opens a mouth on the left or right side of the patient's abdomen. Stools or urinations are involuntarily excreted through the stoma, and such patients will need to attach a bag to the stoma to discharge the contents after discharge. Medically, these patients are called "spoken people.”
  • the applicant has conducted a special study to develop a Chinese medicine ostomy plastic disc formula and a manufacturing method thereof, and the present invention is produced.
  • the present invention provides a Chinese medicine ostomy adhesive disc formulation and a manufacturing method thereof for preventing odor generation in a stoma.
  • a traditional Chinese medicine stoma plastic disc formula is prepared from the following raw materials by weight, 15-50 parts of traditional Chinese medicine ingredients, 10-30 parts of sodium carboxymethyl cellulose, 40-100 parts of medical hot melt adhesive, and polyisobutylene 10-30 Parts, 10-30 parts of paraffin oil, 5-8 parts of pectin, the Chinese medicine ingredients include 5-10 parts of musk and 10-15 parts of musk.
  • the traditional Chinese medicine ingredients further include, 5-10 parts of perilla leaves, 10-15 parts of honeysuckle, 10-15 parts of Chuanxiong, 5-10 parts of clove, 2-4 parts of Cnidium, 2-4 parts of antler powder. 8-10 parts of Rehmannia glutinosa and 15-20 parts of gelatin.
  • the invention discloses a preparation method of a traditional Chinese medicine stoma plastic disc formula, which is applied to the above-mentioned formula of a traditional Chinese medicine stoma plastic disc, wherein the manufacturing method comprises a method for preparing a traditional Chinese medicine component and a method for preparing a rubber compound.
  • the method for preparing a traditional Chinese medicine ingredient comprises the following steps:
  • Step (1) according to the above ratio the medicine component other than gelatin is packaged into the reaction kettle;
  • Step (2) adding purified water of 20 times the quality of the medicinal material for 16-20 hours;
  • Step (3) heating the medicinal material to boiling
  • Step (4) maintaining the temperature between 116-121 ° C for 3-4 h;
  • Step (5) pouring the obtained liquid medicine to obtain a fried
  • Step (6) further adding purified water having a medicinal material 20 times in the reaction kettle, heating the medicinal material to boiling, maintaining the temperature between 116-121 ° C for 1-3 h, pouring the liquid to obtain two frying;
  • Step (7) repeating step (6), pouring the liquid medicine to obtain three fried;
  • Step (8) pour the obtained liquid medicine of one frying, two frying and three frying into the concentration tank;
  • Step (9) The temperature of the concentration tank is controlled between 75-85 ° C, and after stirring until the liquid solution becomes thick, adjust the temperature to 50-60 ° C, add gelatin, continue stirring, until the liquid is completely thick, stop Heat and stir, let it cool naturally, and get the prepared Chinese medicine.
  • the method for manufacturing the rubber compound includes the following steps:
  • Step (10) according to the above ratio, the medical hot melt adhesive, polyisobutylene, paraffin oil is placed in the reaction kettle, heated and stirred until the raw material is completely melted;
  • Step (11) adding sodium carboxymethylcellulose and pectin, and stirring until mixing is uniform;
  • Step (12) is added to the prepared traditional Chinese medicine in the step (9), and the mixture is continuously stirred until the mixture is uniformly mixed to obtain a traditional Chinese medicine stoma.
  • the temperature in the step (11) is controlled between 70 ° C and 90 ° C;
  • the temperature in the step (12) is controlled between 70 ° C and 90 ° C.
  • the leaf alkane in the leaves of the leaves, the amaryl ketone, the triterpenoids and the like can remove the odor of the stoma excrement, and the musk can dilute the odor and ensure the tasteless.
  • clove, perilla leaf and wormwood can inhibit bacteria and deworming, ensuring clean and no inflammation near the stoma;
  • Cnidium, antler powder, etc. can absorb moisture and suppress sweat, ensure stable stoma environment, and the rubber plate and skin are stable;
  • Ai Ye, honeysuckle, Chuanxiong and antler powder combination can reduce swelling and pain, maintain daily care of stoma;
  • the traditional Chinese medicine combination has the effects of preventing rash, preventing sores, and preventing ulceration.
  • the reactor is provided with a jacket heating function, which can be intelligently temperature-controlled, and has an automatic stirring function.
  • a traditional Chinese medicine ostomy plastic disc formula is prepared from the following raw materials by weight, 15 parts of traditional Chinese medicine ingredients, 10 parts of sodium carboxymethyl cellulose, 40 parts of medical hot melt adhesive, 10 parts of polyisobutylene, 10 parts of paraffin oil, fruit 5 parts of rubber; the weight of the traditional Chinese medicine is 5 parts of perilla leaves, 5 parts of musk, 10 parts of honeysuckle, 10 parts of Chuanxiong, 5 parts of clove, 10 parts of Ai leaves, 2 parts of Cnidium, 2 parts of antler powder 8 parts of Rehmannia glutinosa and 15 parts of gelatin.
  • Step (2) adding purified water of 20 times the quality of the medicinal material for 16 hours;
  • step (4) the temperature is maintained at 116 ° C for 3 h;
  • step (6) the temperature is maintained at 116 ° C for 1 h;
  • step (7) the temperature is maintained at 116 ° C for 1 h;
  • step (9) the temperature of the concentration tank is controlled to 75 ° C, and stirred until the liquid solution becomes thick, and the temperature is adjusted to 50 ° C;
  • step (10) the heating temperature is controlled to be 100 ° C;
  • the temperature controlled in step (11) is 70 ° C;
  • the temperature in the step (12) was controlled at 70 °C.
  • a traditional Chinese medicine stoma plastic disc formula is prepared from the following raw materials by weight, 30 parts of traditional Chinese medicine ingredients, 20 parts of sodium carboxymethyl cellulose, 70 parts of medical hot melt adhesive, 20 parts of polyisobutylene, 20 parts of paraffin oil, fruit 7 parts of glue.
  • the traditional Chinese medicine ingredients are: 7 parts of perilla leaves, 7 parts of musk, 13 parts of honeysuckle, 13 parts of Chuanxiong, 7 parts of clove, 13 parts of Ai leaves, 3 parts of Cnidium, 3 parts of staghorn powder, Rehmannia glutinosa 9 Serve, 13 parts of gelatin.
  • Step (2) adding purified water of 20 times the quality of the medicinal material for 16-20 hours;
  • step (4) maintaining the temperature at 118 ° C for 3.5 h;
  • step (6) the temperature is maintained at 118 ° C for 2 h;
  • step (7) maintaining a temperature of 118 ° C 2 h;
  • step (9) the temperature of the concentration tank is controlled to 80 ° C, and stirred until the liquid solution becomes thick, and the temperature is adjusted to 55 ° C;
  • step (10) the heating temperature is controlled to be 125 ° C;
  • the temperature in the step (11) is controlled to 80 ° C;
  • the temperature in the step (12) was controlled at 80 °C.
  • a traditional Chinese medicine ostomy plastic disc formula is prepared from the following raw materials by weight, 50 parts of traditional Chinese medicine ingredients, 30 parts of sodium carboxymethyl cellulose, 100 parts of medical hot melt adhesive, 30 parts of polyisobutylene, 30 parts of paraffin oil, fruit 8 parts of glue.
  • the traditional Chinese medicine ingredients are: 10 parts of perilla leaves, 10 parts of musk, 15 parts of honeysuckle, 15 parts of Chuanxiong, 10 parts of clove, 15 parts of Ai leaves, 4 parts of Cnidium, 4 parts of staghorn powder, 4 parts of Rehmannia glutinosa 10 Serve 20 parts of gelatin.
  • Step (2) adding 20 times of purified medicinal material to soak for 20 hours;
  • step (4) the temperature is maintained at 121 ° C for 4 h;
  • step (6) the temperature is maintained at 121 ° C for 3 h;
  • step (7) the temperature is maintained at 121 ° C for 3 h;
  • step (9) the temperature of the concentration tank is controlled to 85 ° C, and stirred until the liquid solution becomes thick, and the temperature is adjusted to 60 ° C;
  • step (10) the heating temperature is controlled to be 150 ° C;
  • the temperature in the step (11) is controlled at 90 ° C;
  • the temperature in the step (12) was controlled at 90 °C.
  • the components of the alane, the amaryl ketone, the triterpenoids and the like in the leaves of the leaves can remove the odor of the stoma excrement, and the musk can dilute the odor and ensure the odorless;
  • Clove, perilla leaf and wormwood can inhibit bacteria and worms, ensuring clean and no inflammation near the stoma;
  • Cnidium, antler powder, etc. can absorb moisture and suppress sweat, ensuring stable stoma environment, and the rubber plate and skin are stable;
  • Ai Ye, honeysuckle, Chuanxiong and antler powder combination can reduce swelling and pain, maintain daily care of stoma;
  • the traditional Chinese medicine combination has the effects of preventing rash, preventing sores and preventing ulceration.
  • the Chinese medicine and the colloid are perfectly blended in the formula, which does not affect the stickiness, can be peeled off, does not harm the skin, is simple to operate, and is effective to use;
  • the 126 cases of traditional Chinese medicine ostomy plastic disc formula are divided into three groups for clinical trial, the test period is one month, each group of patients are ostomy patients, and the corresponding basic knowledge of stoma is known, and the stoma is replaced in time. Rubber plate, and willing to actively cooperate with this test.
  • the first group 42 cases of the rubber plate prepared by the formulation of the first embodiment; the second group: 42 cases of the rubber plate preparation made by the formula of the embodiment 2; the third group: the same as in the embodiment 3 42 cases of rubber plate were prepared.
  • the first group 41 cases
  • the second group 40 cases
  • the third group 38 cases.
  • Occurrence of odor the first group: 2 cases; the second group 1 case; the third group: 1 case, the total effective rate: 96.6%.
  • Excretion noise the first group: 3 cases; the second group 2 cases; the third group: 2 cases, the total effective rate: 94.1%.
  • Inflammation of the wound the first group: 1 case; the second group 0 cases; the third group: 0 cases, the total effective rate: 99.2%.
  • the invention not only exerts the advantages of mild and effective Chinese medicine on the basis of the improvement of the formula of the plastic disc, but also integrates the traditional Chinese medicine into the colloid to achieve the effect of 1+1 greater than 2. Therefore, the addition of the traditional Chinese medicine solves the stoma of the stoma. Can not control the sound, inflammation, redness and other issues. Reduce stigma in patients with stoma.

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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Abstract

一种中药造口胶盘及其制作方法和应用。所述中药造口胶盘由以下重量份的原料制成：中药成分15-50份，羧甲基纤维素钠10-30份，医用热熔胶40-100份，聚异丁烯10-30份，石蜡油10-30份，果胶5-8份。其中中药成分为：紫苏叶5-10份，藿香5-10份，金银花10-15份，川芎10-15份，丁香5-10份，艾叶10-15份，蛇床子2-4份，鹿角粉2-4份，熟地黄8-10份，明胶15-20份。所述中药成分能够稀释或除去造口***物的臭味，行气防堵，使***稳定无响声，抑菌驱虫，消除造口附近炎症。

Description

一种中药造口胶盘配方及其制作方法 技术领域
本发明涉及一种中药造口胶盘配方及其制作方法，属于造口医疗技术领域。
背景技术
“造口”即消化***或泌尿***疾病引起的，需要通过外科手术治疗对肠管进行分离，将肠管的一端引出到体表(***或尿道移至腹壁)形成一个开口。达到行肠道减压、减轻梗阻、保护远端肠管的吻合或损伤，促进肠道、泌尿道疾病的痊愈，甚至挽救病人的生命。
造口一般是针对直肠、膀胱病变(如直肠癌、膀胱癌、肠梗阻等)，为了保住患者的性命，医生手术切除病变的部位，例如，直肠癌会切除直肠、肛管，膀胱癌会切除膀胱，然后在患者的腹部左侧或者右侧开一个口。大便或者小便通过该造口不自主地排出体外，这类患者在出院以后将需要在造口处粘贴一个袋子来装排出的东西。医学上称这类患者为“造口人”。
“造口人”的身体外形发生了变化，***物不能随意控制，在社交、饮食、异味处理、造口袋的使用，以及其它问题上给患者带来的困扰，有的人甚至对生活感到悲观失望，对前途失去信心。因此，造口人作为社会上特殊群体，需要家人的关爱，需要社会帮助，需要康复指导，更需要人们的理解和社会的认可与支持。
造口患者由于手术干预而导致排便方式发生改变，失去***的控制功能，需在腰部佩戴造口袋收集***物，现有造口袋使用过程中存在造口异味，不能控制响声等问题。使患者存在强烈的病耻感，几乎不愿意外出。
有鉴于此，本申请人对此进行专门研究，开发出一种中药造口胶盘配方及其制作方法，本案由此产生。
发明内容
为了解决现有技术中存在的上述缺陷，本发明提供了防止造口产生异味的一种中药造口胶盘配方及其制作方法。
为了实现上述目的，本发明采取的技术方案如下：
一种中药造口胶盘配方，由以下重量份的原料制成，中药成分15-50份，羧甲基纤维素钠10-30份，医用热熔胶40-100份，聚异丁烯10-30份，石蜡油10-30份，果胶5-8份，所述中药成分包括藿香5-10份，艾叶10-15份。
以重量计，所述中药成分还包括，紫苏叶5-10份，金银花10-15份，川芎10-15份，丁 香5-10份，蛇床子2-4份，鹿角粉2-4份，熟地黄8-10份，明胶15-20份。
一种中药造口胶盘配方的制作方法，应用于上述一种中药造口胶盘配方，所述制作方法包括中药成分制作方法和炼胶制作方法，
其中中药成分制作方法包括如下步骤：
步骤(1)按上述比例，用药袋将除明胶以外的中药成分包好放入反应釜内；
步骤(2)加入药材质量20倍的纯化水浸泡16-20h；
步骤(3)对药材进行加热至沸腾；
步骤(4)维持温度在116-121℃之间3-4h；
步骤(5)将获得的药液倒出获得一煎；
步骤(6)继续在反应釜中加入药材质量20倍的纯化水，对药材进行加热至沸腾后，维持温度在116-121℃之间1-3h，将药液倒出获得二煎；
步骤(7)重复步骤(6)，将药液倒出获得三煎；
步骤(8)将获得的一煎，二煎和三煎的药液倒入浓缩罐内；
步骤(9)浓缩罐温度控制在75-85℃之间，并搅拌至药液变稠后，将温度调节至50-60℃之间，加入明胶，继续搅拌，至药液彻底浓稠，停止加热和搅拌，待其自然冷却，得到制作好的中药。
其中炼胶制作方法包括如下步骤：
步骤(10)按上述比例，将医用热熔胶，聚异丁烯，石蜡油放入反应釜，加热和搅拌至原料完全熔化；
步骤(11)加入羧甲基纤维素钠和果胶，持续搅拌至混合均匀；
步骤(12)加入步骤(9)中制作好的中药，持续搅拌至混合均匀，获得中药造口胶。
所述步骤(10)中控制加热温度在100℃-150℃之间；
所述步骤(11)中控制温度在70℃-90℃之间；
所述步骤(12)中控制温度在70℃-90℃之间。
本发明能实现如下技术效果：
(1)艾叶中的叶烷类，杨梅酮、三萜类等成分可除去造口***物外溢臭味，藿香可稀释异味，保证无味。
(2)川芎，熟地黄可行气防堵，使***时稳定，无***响声；
(3)丁香，紫苏叶和艾叶可抑菌驱虫，保证造口附近清洁无炎症；
(4)该配方中中药与胶体完美融合，既不影响粘性，又能揭掉，不伤害皮肤，操作简单，使用有效；
(5)蛇床子，鹿角粉等可吸湿抑汗，保证造口环境稳定，胶盘与皮肤粘合稳定；
(6)艾叶，金银花，川芎和鹿角粉组合可消肿止痛，维护造口日常护理；
(7)该中药药剂组合具有防红疹，防疮，防疡烂的效果。
具体实施方式
为了使本发明的技术手段及其所能达到的技术效果，能够更清楚更完善的揭露，兹提供了三个个实施例，作如下详细说明：
本发明中用到的反应釜，在以下实施例中，反应釜中设有夹套加热功能，能智能控温，还具有自动搅拌功能。
实施例1
一种中药造口胶盘配方，由以下重量份的原料制成，中药成分15份，羧甲基纤维素钠10份，医用热熔胶40份，聚异丁烯10份，石蜡油10份，果胶5份；以重量计，所述中药成分为，紫苏叶5份，藿香5份，金银花10份，川芎10份，丁香5份，艾叶10份，蛇床子2份，鹿角粉2份，熟地黄8份，明胶15份。
步骤(2)加入药材质量20倍的纯化水浸泡16h；
步骤(4)中，维持温度116℃3h；
步骤(6)中，维持温度116℃1h；
步骤(7)中，维持温度116℃1h；
步骤(9)中，浓缩罐温度控制为75℃，并搅拌至药液变稠后，将温度调节至50℃；
步骤(10)中控制加热温度为100℃；
步骤(11)中控制温度为70℃；
步骤(12)中控制温度为70℃。
实施例2
一种中药造口胶盘配方，由以下重量份的原料制成，中药成分30份，羧甲基纤维素钠20份，医用热熔胶70份，聚异丁烯20份，石蜡油20份，果胶7份。
以重量计，所述中药成分为，紫苏叶7份，藿香7份，金银花13份，川芎13份，丁香7份，艾叶13份，蛇床子3份，鹿角粉3份，熟地黄9份，明胶13份。
步骤(2)加入药材质量20倍的纯化水浸泡16-20h；
步骤(4)中，维持温度118℃3.5h；
步骤(6)中，维持温度118℃2h；
步骤(7)中，维持温度118℃2h；
步骤(9)中，浓缩罐温度控制为80℃，并搅拌至药液变稠后，将温度调节至55℃；
步骤(10)中控制加热温度为125℃；
步骤(11)中控制温度为80℃；
步骤(12)中控制温度为80℃。
实施例3
一种中药造口胶盘配方，由以下重量份的原料制成，中药成分50份，羧甲基纤维素钠30份，医用热熔胶100份，聚异丁烯30份，石蜡油30份，果胶8份。
以重量计，所述中药成分为，紫苏叶10份，藿香10份，金银花15份，川芎15份，丁香10份，艾叶15份，蛇床子4份，鹿角粉4份，熟地黄10份，明胶20份。
步骤(2)加入药材质量20倍的纯化水浸泡20h；
步骤(4)中，维持温度121℃4h；
步骤(6)中，维持温度121℃3h；
步骤(7)中，维持温度121℃3h；
步骤(9)中，浓缩罐温度控制为85℃，并搅拌至药液变稠后，将温度调节至60℃；
步骤(10)中控制加热温度为150℃；
步骤(11)中控制温度为90℃；
步骤(12)中控制温度为90℃。
在上述实施例1-3中，艾叶中的叶烷类，杨梅酮、三萜类等成分可除去造口***物外溢臭味，藿香可稀释异味，保证无味；
川芎，熟地黄可行气防堵，使***时稳定，无***响声；
丁香，紫苏叶和艾叶可抑菌驱虫，保证造口附近清洁无炎症；
蛇床子，鹿角粉等可吸湿抑汗，保证造口环境稳定，胶盘与皮肤粘合稳定；
艾叶，金银花，川芎和鹿角粉组合可消肿止痛，维护造口日常护理；
该中药药剂组合具有防红疹，防疮，防疡烂的效果。
该配方中中药与胶体完美融合，既不影响粘性，又能揭掉，不伤害皮肤，操作简单，使用有效；
本发明的中药造口胶盘配方共126例分为三组应用于临床试验，试验期为一个月，每组患者均为造口病人，且懂得相应的造口基本护理知识，及时更换造口胶盘，并且愿意积极配合 本试验。第一组：以实施例1中的配方制成的胶盘护理42例；第二组：以实施例2中的配方制成的胶盘护理42例；第三组：以实施例3中的配方制成的胶盘护理42例。
其中，坚持使用本发明配方制成的胶盘患者共119例：第一组：41例，第二组：40例，第三组：38例。
试验一个月后：
出现异味：第一组：2例；第二组1例；第三组：1例，总有效率：96.6％。
***响声：第一组：3例；第二组2例；第三组：2例，总有效率：94.1％。
伤口出现炎症：第一组：1例；第二组0例；第三组：0例，总有效率：99.2％。
本发明在对胶盘配方改进的基础上，又发挥了中药温和有效的优势，将传统的中药融入胶体中，达到1+1大于2的效果，因此中药的加入解决造口存在造口异味，不能控制响声，发炎红肿等问题。降低造口患者病耻感。
以上内容是结合本发明的优选实施方式对所提供技术方案所作的进一步详细说明，不能认定本发明具体实施只局限于上述这些说明，对于本发明所属技术领域的普通技术人员来说，在不脱离本发明构思的前提下，还可以做出若干简单推演或替换，都应当视为属于本发明的保护范围。

Claims (4)

  1. 一种中药造口胶盘配方，其特征在于：由以下重量份的原料制成，中药成分15-50份，羧甲基纤维素钠10-30份，医用热熔胶40-100份，聚异丁烯10-30份，石蜡油10-30份，果胶5-8份，所述中药成分包括藿香5-10份，艾叶10-15份。
  2. 如权利要求1所述的一种中药造口胶盘配方，其特征在于：以重量计，所述中药成分还包括，紫苏叶5-10份，金银花10-15份，川芎10-15份，丁香5-10份，蛇床子2-4份，鹿角粉2-4份，熟地黄8-10份，明胶15-20份。
  3. 一种中药造口胶盘配方的制作方法，应用于权利要求1或2所述的一种中药造口胶盘配方，其特征在于：所述制作方法包括中药成分制作方法和炼胶制作方法，
    其中中药成分制作方法包括如下步骤：
    步骤(1)按上述比例，用药袋将除明胶以外的中药成分包好放入反应釜内；
    步骤(2)加入药材质量20倍的纯化水浸泡16-20h；
    步骤(3)对药材进行加热至沸腾；
    步骤(4)维持温度在116-121℃之间3-4h；
    步骤(5)将获得的药液倒出获得一煎；
    步骤(6)继续在反应釜中加入药材质量20倍的纯化水，对药材进行加热至沸腾后，维持温度在116-121℃之间1-3h，将药液倒出获得二煎；
    步骤(7)重复步骤(6)，将药液倒出获得三煎；
    步骤(8)将获得的一煎，二煎和三煎的药液倒入浓缩罐内；
    步骤(9)浓缩罐温度控制在75-85℃之间，并搅拌至药液变稠后，将温度调节至50-60℃之间，加入明胶，继续搅拌，至药液彻底浓稠，停止加热和搅拌，待其自然冷却，得到制作好的中药；
    其中炼胶制作方法包括如下步骤：
    步骤(10)按上述比例，将医用热熔胶，聚异丁烯，石蜡油放入反应釜，加热和搅拌至原料完全熔化；
    步骤(11)加入羧甲基纤维素钠和果胶，持续搅拌至混合均匀；
    步骤(12)加入步骤(9)中制作好的中药，持续搅拌至混合均匀，获得中药造口胶。
  4. 如权利要求3所述的一种中药造口胶盘配方的制作方法，其特征在于：
    所述步骤(10)中控制加热温度在100℃-150℃之间；
    所述步骤(11)中控制温度在70℃-90℃之间；
    所述步骤(12)中控制温度在70℃-90℃之间。
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