WO2018231175A3 - Non-steroidal anti-inflammatory drugs and h2 receptor antagonist combinations for treatment of pain and inflammation - Google Patents
Non-steroidal anti-inflammatory drugs and h2 receptor antagonist combinations for treatment of pain and inflammation Download PDFInfo
- Publication number
- WO2018231175A3 WO2018231175A3 PCT/TR2017/050635 TR2017050635W WO2018231175A3 WO 2018231175 A3 WO2018231175 A3 WO 2018231175A3 TR 2017050635 W TR2017050635 W TR 2017050635W WO 2018231175 A3 WO2018231175 A3 WO 2018231175A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- receptor antagonist
- inflammation
- pain
- treatment
- steroidal anti
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention provides single unit pharmaceutical dosage forms comprising a therapeutically effective amount of at least one propionic acid derivative NSAID that inhibits both COX-1 and COX-2; in combination with a therapeutically effective amount of at least one H2 receptor antagonist as a gastro protective agent.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
TR2016/18765 | 2016-12-16 | ||
TR2016/18765A TR201618765A2 (en) | 2016-12-16 | 2016-12-16 | Non-steroidal anti-inflammatory drugs and h2 receptor antagonist combinations for treatment of pain and inflammation |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2018231175A2 WO2018231175A2 (en) | 2018-12-20 |
WO2018231175A3 true WO2018231175A3 (en) | 2019-03-07 |
Family
ID=64308786
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/TR2017/050635 WO2018231175A2 (en) | 2016-12-16 | 2017-12-07 | Non-steroidal anti-inflammatory drugs and h2 receptor antagonist combinations for treatment of pain and inflammation |
Country Status (2)
Country | Link |
---|---|
TR (1) | TR201618765A2 (en) |
WO (1) | WO2018231175A2 (en) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008027963A2 (en) * | 2006-08-31 | 2008-03-06 | Horizon Therapeutics, Inc. | Nsaid dose unit formulations with h2-receptor antagonists and methods of use |
WO2013054352A1 (en) * | 2011-08-17 | 2013-04-18 | Cadila Healthcare Limited | Pharmaceutical compositions of ibuprofen and famotidine |
US20150132410A1 (en) * | 2013-11-14 | 2015-05-14 | Michael M. Jacobs | Compositions and methods for the prevention and treatment of alcohol-induced hangover syndrome |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6056143B2 (en) | 1979-08-02 | 1985-12-09 | 山之内製薬株式会社 | Amidine derivatives and their production method |
HU196775B (en) | 1986-08-05 | 1989-01-30 | Richter Gedeon Vegyeszet | Process for production of morfologically unique new modifications of famotidin and medical compositions containing such substances |
US4868214A (en) | 1987-11-17 | 1989-09-19 | Analgesic Associates | Onset-hastened/enhanced analgesia |
ES2058024B1 (en) | 1992-11-10 | 1995-05-01 | Menarini Lab | NEW ARILPROPIONIC DERIVATIVE, MANUFACTURING PROCEDURE OF THE SAME AND ITS USE AS AN ANALGESIC. |
SE9600070D0 (en) | 1996-01-08 | 1996-01-08 | Astra Ab | New oral pharmaceutical dosage forms |
EA006398B1 (en) | 2001-06-01 | 2005-12-29 | Поузен Инк. | Pharmaceutical compositions for coordinated delivery of nsaids |
US20050163847A1 (en) | 2004-01-21 | 2005-07-28 | Andrx Pharmaceuticals, Llc | Pharmaceutical formulations containing a non-steroidal antiinflammatory drug and an antiulcerative drug |
US20050249806A1 (en) | 2004-02-10 | 2005-11-10 | Santarus, Inc. | Combination of proton pump inhibitor, buffering agent, and nonsteroidal anti-inflammatory drug |
US8067033B2 (en) | 2007-11-30 | 2011-11-29 | Horizon Pharma Usa, Inc. | Stable compositions of famotidine and ibuprofen |
US20090233970A1 (en) | 2008-03-11 | 2009-09-17 | Nickell Robert P | Combined nsaid and acid blocker formulation and method |
-
2016
- 2016-12-16 TR TR2016/18765A patent/TR201618765A2/en unknown
-
2017
- 2017-12-07 WO PCT/TR2017/050635 patent/WO2018231175A2/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008027963A2 (en) * | 2006-08-31 | 2008-03-06 | Horizon Therapeutics, Inc. | Nsaid dose unit formulations with h2-receptor antagonists and methods of use |
WO2013054352A1 (en) * | 2011-08-17 | 2013-04-18 | Cadila Healthcare Limited | Pharmaceutical compositions of ibuprofen and famotidine |
US20150132410A1 (en) * | 2013-11-14 | 2015-05-14 | Michael M. Jacobs | Compositions and methods for the prevention and treatment of alcohol-induced hangover syndrome |
Also Published As
Publication number | Publication date |
---|---|
TR201618765A2 (en) | 2018-07-23 |
WO2018231175A2 (en) | 2018-12-20 |
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