WO2018228160A1 - Therapy unit and therapy device comprising same - Google Patents

Therapy unit and therapy device comprising same Download PDF

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Publication number
WO2018228160A1
WO2018228160A1 PCT/CN2018/088172 CN2018088172W WO2018228160A1 WO 2018228160 A1 WO2018228160 A1 WO 2018228160A1 CN 2018088172 W CN2018088172 W CN 2018088172W WO 2018228160 A1 WO2018228160 A1 WO 2018228160A1
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Prior art keywords
treatment device
infrared illumination
module
illumination module
infrared
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PCT/CN2018/088172
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French (fr)
Chinese (zh)
Inventor
魏勋斌
黄勇
丁玎
初明星
孟庆强
索元震
王雪
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黄勇
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Publication of WO2018228160A1 publication Critical patent/WO2018228160A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0622—Optical stimulation for exciting neural tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/002—Magnetotherapy in combination with another treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/004—Magnetotherapy specially adapted for a specific therapy
    • A61N2/006—Magnetotherapy specially adapted for a specific therapy for magnetic stimulation of nerve tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/02—Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0626—Monitoring, verifying, controlling systems and methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0632—Constructional aspects of the apparatus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
    • A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
    • A61N2005/0645—Applicators worn by the patient
    • A61N2005/0647—Applicators worn by the patient the applicator adapted to be worn on the head
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
    • A61N2005/0659—Radiation therapy using light characterised by the wavelength of light used infrared
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0664—Details

Definitions

  • the present invention generally relates to the field of medical device technology, and in particular to a magneto-optical integrated brain stimulation device and a treatment device including the same, which can stimulate a plurality of regions in a patient's head to achieve treatment of Alzheimer's The purpose of the disease.
  • AD Alzheimer's disease
  • AD Alzheimer's disease
  • AD Alzheimer's disease
  • ⁇ -amyloid ⁇ -protein plaque in the brain, which has been shown to have strong neurotoxicity, which can destroy the nervous tissue structure.
  • Alzheimer's disease accounts for about 6% of the elderly over the age of 65, and some patients develop before the age of 65. With the prolongation of life expectancy and the aging of the population, Alzheimer's disease patients are increasing both globally and in China, and bring huge social burden and economic burden.
  • the clinical treatment methods for Alzheimer's disease are mainly to try to delay the disease process, the treatment effect is limited, and no drugs have been proved to completely prevent the development of Alzheimer's disease, and can not be reversed.
  • Existing therapeutic drugs such as cholinesterase antagonists and NMDA receptor antagonists, have major side effects, and these drugs may even worsen the cognitive impairment of the patient.
  • cholinesterase antagonists and NMDA receptor antagonists have major side effects, and these drugs may even worsen the cognitive impairment of the patient.
  • near-infrared light therapy has been reported to effectively remove the deposition of ⁇ -amyloid plaques in the cerebral cortex, which is considered to be one of the important causes of Alzheimer's disease.
  • This treatment can also improve cerebral arterial blood. Flow, improve blood supply to the cerebral cortex, but there is no significant improvement in the functional activity of the patient's cranial nerves.
  • Transcranial direct current stimulation can only reach the cerebral cortex, and some deep brain regions involved in functional networks, such as the prefrontal cortex, island leaves, cingulate gyrus and other parts, can no longer be further involved.
  • Transcranial magnetic therapy can produce a rapidly changing induced magnetic field, acting on the brain and producing weak antiparallel induced currents in the brain, which can affect the sum of post-synaptic potentials of pyramidal neurons in the cerebral cortex, leading to abnormal nerve stimulation at the stimulation site. Or inhibition, the brain's physiological and functional changes, but high-frequency repeated transcranial magnetic stimulation can easily cause headaches, nausea and even the possibility of causing epilepsy, which may cause potential harm to the human body.
  • the invention aims to remove the deposition of ⁇ -amyloid plaque, which is one of the pathogenic factors, and to excite the nerve activity in a treatment process of Alzheimer's disease, reaching 1+1>2. treatment effect.
  • the present invention provides a treatment device comprising: a housing for a user to wear on a head; a magnet on which the magnet is mounted a near-infrared illumination module mounted on the housing and capable of emitting near-infrared illumination toward the interior of the housing; and a control module coupled to the near-infrared illumination module.
  • the magnet is an electromagnetic coil
  • the control module is coupled to the electromagnetic coil to control the electromagnetic coil and the near infrared illumination module.
  • the near infrared illumination module is positioned to correspond to one or more of a temporal, frontal, parietal, occipital, and hippocampal formation of a user's brain.
  • a plurality of magnets and a plurality of near-infrared illumination modules are interposed in a same plane as the plurality of near-infrared illumination modules, or the magnets are located in a near-infrared illumination module
  • the front face, or the magnet is located behind the near infrared illumination module.
  • the treatment device further includes a heat dissipation fan disposed adjacent to the near infrared illumination module.
  • the near-infrared illumination module includes a plurality of near-infrared light emitting diodes and a transparent plate covering the plurality of near-infrared light emitting diodes, and the near-infrared light emitting diode emits a near-infrared wavelength of 780-2526 nm.
  • the illumination mode is divided into continuous light irradiation or pulsed light irradiation.
  • control module can adjust an illumination intensity of the near infrared illumination module and/or a current supplied to the electromagnetic coil.
  • the magnetic module is circular, elliptical or "8" shaped.
  • the near infrared illumination module is disposed at an eye, a forehead, a temple, a hindbrain corresponding to a patient, and/or the magnet is located in an upper half of the user's head.
  • the head treatment device is an Alzheimer's disease treatment device.
  • the present invention also provides a treatment apparatus comprising: a seat portion; the treatment device as described above, wherein the treatment device is coupled to the seat portion; and a cognitive exercise device, the cognitive exercise device being coupled to the a seat portion; and a console disposed on the seat portion, electrically coupled to the treatment device and the cognitive exercise device to control the treatment device and the cognitive exercise device.
  • FIG. 1 is a schematic structural view of a head treatment device according to an embodiment of the present invention.
  • Figure 2 is a perspective view of the head treatment device as viewed from above, in accordance with one embodiment of the present invention
  • Figure 3 is a perspective view of the head treatment device as viewed from below, in accordance with one embodiment of the present invention.
  • FIG. 4 is a schematic view showing the arrangement of a magnetic module and a near-infrared illumination module according to an embodiment of the present invention
  • 5A and 5B illustrate the therapeutic effects of the treatment device 1 according to the present invention
  • FIG. 6 shows a treatment device in accordance with another embodiment of the present invention.
  • Figure 7 shows a logic diagram of a treatment device in accordance with another embodiment of the present invention.
  • first and second are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated.
  • features defining “first” or “second” may include one or more of the described features, either explicitly or implicitly.
  • the meaning of “plurality” is two or more unless specifically and specifically defined.
  • connection or integral connection: it can be mechanical connection, electrical connection or communication with each other; it can be directly connected or indirectly connected through an intermediate medium, which can be the internal connection of two elements or the interaction of two elements. relationship.
  • intermediate medium can be the internal connection of two elements or the interaction of two elements. relationship.
  • the first feature "on” or “under” the second feature may include direct contact of the first and second features, and may also include first and second features, unless otherwise explicitly defined and defined. It is not in direct contact but through additional features between them.
  • the first feature “above”, “above” and “above” the second feature includes the first feature directly above and above the second feature, or merely indicating that the first feature level is higher than the second feature.
  • the first feature “below”, “below” and “below” the second feature includes the first feature directly above and above the second feature, or merely indicating that the first feature level is less than the second feature.
  • a first embodiment of the present invention provides a treatment device 1 that can be worn on the head, for example, for treating Alzheimer's disease.
  • the treatment device is a photomagnetic integrated device.
  • the treatment device 1 of the present invention includes a near infrared illumination module 8 and a magnetic module 7 (i.e., a transcranial magnetic stimulation module).
  • Near-infrared light source illumination is mainly used to reduce plaque formation of ⁇ -amyloid and reduce damage to the nervous system.
  • the magnetic module is mainly used to stimulate the nervous system in the area of Alzheimer's disease, enhance the activity of nerves, and promote nerve repair. Both modules have the ability to increase cerebral blood volume, which ensures the blood supply needed during nerve repair. The device systematically improves the therapeutic effect on Alzheimer's disease from the above three aspects.
  • the near-infrared illumination module 8 and the magnetic module 7 are coordinated and cooperate with each other.
  • the magnetic module 7 has a high frequency such as 1 Hz.
  • the electromagnetic waves of the frequency stimulate the brain nerves for several minutes, which increases the excitability of the nerves.
  • the near-infrared wavelength can be adjusted to vary between 780 and 2526 nm, and the magnetic module 7 can also stimulate the brain nerves at frequencies up to 20 Hz or higher.
  • the device achieves the best by alternating the method of near-infrared irradiation and electromagnetic stimulation. treatment effect.
  • FIG. 2 and 3 respectively show perspective views of the treatment device 1 of the present invention, wherein Fig. 2 is a perspective view from above, and Fig. 3 is a perspective view from below.
  • the treatment device 1 of the present invention includes a housing 2.
  • the outer casing 2 is, for example, substantially in the shape of a helmet that can substantially cover the wearer's head.
  • the outer casing 2 has an internal cavity that is substantially shaped to match the wearer's head.
  • the size of the outer casing 2 is preferably adjustable to accommodate different patient needs.
  • the magnetic module 7 and the near-infrared illumination module 8 are respectively disposed on the outer casing 2, for example, on the inner wall of the outer casing 2 for applying treatment or physical therapy to the head of the patient wearing the treatment device 1 of the present invention.
  • the near-infrared light illumination module 8 and the magnetic module 7 are disposed inside the outer casing 2 so as to be openable and contracted by the connecting member.
  • the near-infrared light irradiation module 8 and the magnetic module 7 are gathered and disposed in the treatment device 1.
  • the near-infrared light illumination module 8 and the magnetic module 7 are properly opened within the outer casing 2 to be closer to the patient's head.
  • the magnetic module 7 is for example a permanent magnet.
  • the magnetic module 7 is an electromagnetic coil. By adjusting the current intensity through the electromagnetic coil, the magnetic force, intensity and magnetic field direction of the penetration can be adjusted to suit the treatment needs of different lesions.
  • the treatment device 1 further comprises a control unit (not shown) for controlling the operation of the magnetic module 7 and/or the near-infrared light illumination module 8.
  • the control unit can be arranged, for example, on the housing 2, or it can be a separate control handle, electrically coupled to the near-infrared illumination module 8 and/or the magnetic module 7 to facilitate user operation.
  • the control unit controls, for example, the magnetic force, the intensity and the direction of the magnetic field and the frequency of change of the magnetic module 7, as well as the illumination intensity and wavelength of the near-infrared light illumination module 8.
  • the near-infrared light illumination module 8 includes an illumination module housing 9, a near-infrared light emitting diode array 10, and a heat dissipation fan 11.
  • the position of the near-infrared light illumination module 8 corresponds at least to one or more of the temporal, frontal, parietal, occipital, and hippocampal structures of the patient's brain to illuminate, but is not limited to, these locations.
  • the near-infrared wavelength of the near-infrared light-emitting diode is mainly concentrated at 780-2526 nm.
  • the illumination mode can be continuous light or pulsed light.
  • the near-infrared illumination diode array 10 is covered with a transparent illumination module casing 9 to prevent the human head skin from contacting the near-infrared light-emitting diode lamp bead and causing harm to the human body.
  • the near-infrared light illuminating module the rear cooling fan 11 can be close to Infrared LEDs dissipate heat.
  • the control circuit or control logic of the controlled unit controls the illumination intensity of the near-infrared light-emitting diodes in each of the one or more near-infrared light illumination modules 8 according to parameters such as preset illumination intensity.
  • the parameters such as the light intensity of the near-infrared light-emitting diodes on each of the near-infrared light-irradiating modules 8 may be respectively set, that is, the light intensity of the near-infrared light-emitting diodes on each of the near-infrared light-irradiating modules 8 Etc. can be controlled separately.
  • the size and geometry of the magnetic module 7 can be specially designed to be circular, elliptical or "8" shaped, etc., and the number is not limited.
  • the stimulation intensity and stimulation mode can be set by the control circuit or control logic of the control unit. This magnetic field can perform magnetic stimulation to a specific cerebral cortex of a patient. The adjustment can be made according to the requirements of the stimulation site and the stimulation depth.
  • the near-infrared illumination module 8 and the magnetic module 7 can be arranged in various ways, including but not limited to, the magnetic module and the near-infrared illumination module 8 are interspersed in the same plane, or the magnetic module is located.
  • the front side of the near-infrared illumination module 8, or the magnetic module is located behind the near-infrared illumination module 8, and the like.
  • the inventors of the present invention have found that the therapeutic effect of the brain region which is continuously stimulated for a long time is weakened, and the stimulation of different brain regions such as the dorsolateral prefrontal cortex, the Broca region or the stimulation of the same region but belonging to different brain hemispheres is markedly improved.
  • the cognitive ability of the patient In order to achieve the best therapeutic effect for patients with Alzheimer's disease, the magnetic module 7 and the near-infrared illumination module 8 are designed in a variety of interspersed arrangement structures in the same plane, and the best therapeutic effect can be obtained.
  • Fig. 4 shows a preferred arrangement of the magnetic module and the near-infrared illumination module 8, but the specific arrangement and the number of modules are not limited thereto.
  • a total of 10 near-infrared light illumination modules are arranged in Fig. 4, which are embedded in the inside of the housing 2 of the treatment device 1, wherein there are 2 blocks near the eye, 2 near the forehead, 2 near the left and right temples, and 4 blocks near the hindbrain. .
  • the five magnetic modules are located in the upper part of the user's head and are connected to the housing by spring means. The angle and length can be adjusted according to the user's condition.
  • a variety of working modes are set for near-infrared light irradiation and electromagnetic stimulation, and the two can work separately or simultaneously, or alternately.
  • the choice of how to work can be based on the patient's own situation. For example, if the patient responds strongly to electromagnetic stimulation, the intensity or frequency of the electromagnetic stimulation can be appropriately reduced, or the stimulation site can be changed. For example, if the ⁇ -amyloid plaque in the brain is not significantly changed according to the results of the head examination, the stimulation intensity of near-infrared light can be appropriately increased.
  • the stimulation time and working style can also be appropriately adjusted according to the examination results of the patient's cognitive ability.
  • the invention aims at the etiology and clinicopathological manifestation of Alzheimer's disease, and the first use of the opto-magnetic integrated stimulation device reduces the deposition of ⁇ -amyloid plaque in one treatment and plays the role of excitatory neurons. Improvements have also been made to the helmet worn by the treatment to optimize the position of the near-infrared light module and the magnetic stimulation module.
  • FIG. 5A and 5B show the effect of treating the Alzheimer's disease using the treatment device 1 of the present invention.
  • a mouse using a genetically modified AD model was used as an experimental research subject, and a near-infrared light helmet capable of emitting a specific wavelength according to the present invention was worn on the head of a test group (IR) mouse, while the control group ( Sham)
  • the head of the mouse is only carried with a helmet without a near-infrared emitting module.
  • the changes of ⁇ -amyloid plaques in the brain of the test group and the control group before and after treatment were observed after 6 months of the test.
  • a treatment device 100 in accordance with another embodiment of the present invention is described below with reference to FIG.
  • the treatment device 100 comprises the treatment device 1 of the invention.
  • the treatment device 100 includes a seat portion 12.
  • the seat portion 12 includes a base and a backrest for enabling a patient to sit comfortably thereon.
  • the treatment device 1 can be mounted, for example, on the seat portion 12 by a bracket 13 that can be adjusted relative to the position and height of the seat portion 12 to accommodate the wear requirements of the patient seated in the seat portion 12.
  • the seat portion 12 can also be provided with a human-machine interface and a power switch, for example, at a position convenient for operation, thereby operating the treatment device 1 and the treatment device 1.
  • a control unit of the treatment device 1 such as a near-infrared light irradiation control unit and an electromagnetic adjustment control unit, may be disposed on the seat portion and irradiated with near-infrared light of the treatment device 1
  • the module and the magnetic module are electrically connected for control.
  • the treatment device 100 shown in FIG. 6 also includes a cognitive exercise device 14.
  • the cognitive exercise device 14 is disposed at the front of the seat portion 12 and faces the patient sitting on the seat portion 12.
  • the cognitive exercise device 14 can be coupled to the seat portion by a bracket 15.
  • the cognitive exercise device 14 is, for example, a display on which information about cognitive exercise can be displayed for different patient types.
  • the treatment device 100 also includes a console 16.
  • the console 16 is connected to the treatment device 1 and the front exercise device 14 by, for example, a data line, and the near-infrared light illumination control unit and the electromagnetic adjustment control unit of the treatment device 1 and the front cognitive exercise device can be controlled. 14.
  • the control unit of the treatment device 1 can therefore also be integrated into the console 16.
  • Figure 7 shows a logic diagram of a treatment device 100 in accordance with the present invention.
  • the treatment device 100 includes a seat portion 12, a treatment device 1, and a cognitive exercise device 14.
  • the main control circuit of the treatment device 100 is disposed on the seat portion 12 to provide an operational interface to the user or physician via the console 16.
  • the master control circuit is the control core of the therapy device 100 in which computer programs or control logic are stored. It is unidirectionally or bidirectionally communicated with the near infrared illumination module and magnetic module of the treatment device 1 and the cognitive exercise device, respectively, to control the entire treatment process.
  • the user inputs a command through the graphical user interface of the console 16, and after receiving the user input, the main control circuit issues instructions to the treatment device 1 and the cognitive exercise device 14 to control the intensity, wavelength, and magnetic stimulation intensity of the near infrared radiation. And the content displayed on the cognitive exercise device 14 to provide treatment to the patient sitting on the seat portion 12.
  • the present invention has been described above by taking Alzheimer's disease as an example. It will be understood by a person skilled in the art that the scope of protection of the present invention is not limited thereto and can be applied to the treatment of other conditions.

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Abstract

The present invention provides a therapy unit, comprising: a housing worn by a user on the head; a magnet mounted on the housing; and a near-infrared irradiation module mounted on the housing and capable of performing near-infrared irradiation towards the interior of the housing; and a control module coupled with the near-infrared irradiation module. The present invention also provides a therapy device comprising the therapy unit.

Description

治疗装置及包括该治疗装置的治疗设备Therapeutic device and therapeutic device including the same 技术领域Technical field
本发明大致涉及医疗器械技术领域，尤其涉及一种光磁一体化颅脑刺激装置以及包括该装置的治疗设备，用所述装置能够刺激患者头部内的多个区域以达到治疗阿尔兹海默症的目的。The present invention generally relates to the field of medical device technology, and in particular to a magneto-optical integrated brain stimulation device and a treatment device including the same, which can stimulate a plurality of regions in a patient's head to achieve treatment of Alzheimer's The purpose of the disease.
背景技术Background technique
阿尔兹海默病(Alzheimer’s disease,AD)俗称老年痴呆症，是一种起病隐匿的进行性发展的神经***退行性病变引起的痴呆，其发病进程缓慢并随着时间不断恶化，早期症状是出现短期记忆受损。随着疾病的发展，会出现语言功能障碍、情绪不稳定、难以自理和行为异常等，最终丧失身体机能并导致死亡。阿尔兹海默病的成因至今仍然不明，从目前的研究来看，该病的可能因素和假说多达30多种。医学上认为，该疾病的进程可能主要与大脑中β-淀粉样蛋白(Amyloid β-protein)斑块沉积有很大关系，该蛋白已经被证实具有很强的神经毒性，它可以破坏神经组织结构。另外通过影像学对大脑的扫描图可以看出由于脑神经活动减少导致大脑皮层的退行性萎缩。阿尔兹海默病在65岁以上老人中约有6％的发病率，也有部分患者在65岁之前就发病。随着人均寿命的延长和人口老龄化的加剧，阿尔兹海默病患者在全球和中国都在不断增多，并带来了巨大的社会负担和经济负担。Alzheimer's disease (AD), commonly known as Alzheimer's disease (AD), is a progressive dementia caused by degenerative neurological degenerative diseases. Its pathogenesis is slow and worsens over time. Early symptoms are Short-term memory impairment. As the disease progresses, language dysfunction, emotional instability, difficulty in self-care, and abnormal behavior can occur, eventually losing physical function and leading to death. The cause of Alzheimer's disease remains unclear. From the current research, there are more than 30 possible factors and hypotheses. Medically, the progression of the disease may be mainly related to the deposition of β-amyloid β-protein plaque in the brain, which has been shown to have strong neurotoxicity, which can destroy the nervous tissue structure. . In addition, by scanning the image of the brain, it can be seen that the degeneration of the cerebral cortex is caused by the decrease of cranial nerve activity. Alzheimer's disease accounts for about 6% of the elderly over the age of 65, and some patients develop before the age of 65. With the prolongation of life expectancy and the aging of the population, Alzheimer's disease patients are increasing both globally and in China, and bring huge social burden and economic burden.
目前，阿尔兹海默病在临床上已有的治疗方法主要是试图延缓疾病进程，治疗效果有限，还并没有任何药物被证明可以完全阻止阿尔兹海默病的发展，更不能逆转。现有的治疗药物，如胆碱酯酶拮抗剂和NMDA受体拮抗剂，都有较大的副作用，这些药物对病人来说，甚至可能会加重其认知功能 的损害程度。现阶段，世界上还有一些在研发中的针对阿尔兹海默病人脑神经细胞内变异蛋白质的药物，在实验老鼠上看到一些效果，但人体试验成功的案例并没有报道。At present, the clinical treatment methods for Alzheimer's disease are mainly to try to delay the disease process, the treatment effect is limited, and no drugs have been proved to completely prevent the development of Alzheimer's disease, and can not be reversed. Existing therapeutic drugs, such as cholinesterase antagonists and NMDA receptor antagonists, have major side effects, and these drugs may even worsen the cognitive impairment of the patient. At this stage, there are some drugs in the world that are in the development of brain proteins in Alzheimer's patients, and some effects are seen in experimental mice, but the success of human trials has not been reported.
近年来，国内外开始出现运用物理因子治疗阿尔兹海默病的方法，例如，近红外光治疗、经颅直流电刺激、经颅磁治疗等。近红外光治疗法被报道可以有效的清除大脑皮层的β-淀粉样蛋白斑块的沉积，而该蛋白被认为是阿尔兹海默病的重要成因之一，该治疗方法还可以提升脑动脉血流量，改善大脑皮质供血情况，但对于患者脑神经的功能活动减弱和退化没有明显的改善。经颅直流电刺激效果只能到达大脑皮层，而一些功能网络所涉及到的深部脑区，如前额叶内侧、岛叶、扣带回等部位，不能再进一步涉及。而经颅磁疗法可产生快速变化的感应磁场，作用于大脑并在脑内产生弱的反向平行感应电流,可影响大脑皮层内锥体神经元突触后电位总和，导致刺激部位神经异常兴奋或抑制，使大脑生理和功能改变，但高频度重复的经颅磁刺激容易引起患者头疼、恶心甚至有引发癫痫的可能性，这会对人体造成潜在的危害。In recent years, methods for treating Alzheimer's disease using physical factors have begun to appear at home and abroad, for example, near-infrared light therapy, transcranial direct current stimulation, and transcranial magnetic therapy. Near-infrared light therapy has been reported to effectively remove the deposition of β-amyloid plaques in the cerebral cortex, which is considered to be one of the important causes of Alzheimer's disease. This treatment can also improve cerebral arterial blood. Flow, improve blood supply to the cerebral cortex, but there is no significant improvement in the functional activity of the patient's cranial nerves. Transcranial direct current stimulation can only reach the cerebral cortex, and some deep brain regions involved in functional networks, such as the prefrontal cortex, island leaves, cingulate gyrus and other parts, can no longer be further involved. Transcranial magnetic therapy can produce a rapidly changing induced magnetic field, acting on the brain and producing weak antiparallel induced currents in the brain, which can affect the sum of post-synaptic potentials of pyramidal neurons in the cerebral cortex, leading to abnormal nerve stimulation at the stimulation site. Or inhibition, the brain's physiological and functional changes, but high-frequency repeated transcranial magnetic stimulation can easily cause headaches, nausea and even the possibility of causing epilepsy, which may cause potential harm to the human body.
综上所述，虽然目前已经发展了一些对于阿尔兹海默病的无创物理治疗方法，但是这些方法都有各自的优点和局限性。而且无论单独实行哪一种治疗方法都只能在该病的某一方面起作用，而不能针对目前已经被认知的病因进行一个综合***的治疗。本发明旨在阿尔兹海默症患者的一次治疗过程中，既能够做到清除致病因子之一的β-淀粉样蛋白斑块的沉积，又能够兴奋神经活动，达到1+1>2的治疗效果。In summary, although some non-invasive physical therapy methods for Alzheimer's disease have been developed, these methods have their own advantages and limitations. Moreover, no matter which treatment method is administered alone, it can only work in one aspect of the disease, and cannot be treated in a comprehensive system for the cause that is currently recognized. The invention aims to remove the deposition of β-amyloid plaque, which is one of the pathogenic factors, and to excite the nerve activity in a treatment process of Alzheimer's disease, reaching 1+1>2. treatment effect.
背景技术部分的内容仅仅是发明人所知晓的技术，并不当然代表本领域的现有技术。The content of the background art is only a technique known to the inventors and does not of course represent the prior art in the art.
发明内容Summary of the invention
针对现有技术存在问题中的一个或多个，本发明提供一种治疗装置，包括：壳体，所述壳体可供用户穿戴在头部；磁体，所述磁体安装在所述壳体上；近红外照射模块，所述近红外照射模块安装在所述壳体上并可朝所述壳 体内部发射近红外照射；和控制模块，所述控制模块与所述近红外照射模块耦合。In response to one or more of the problems of the prior art, the present invention provides a treatment device comprising: a housing for a user to wear on a head; a magnet on which the magnet is mounted a near-infrared illumination module mounted on the housing and capable of emitting near-infrared illumination toward the interior of the housing; and a control module coupled to the near-infrared illumination module.
根据本发明的另一个方面，所述磁体为电磁线圈，所述控制模块与所述电磁线圈耦合，控制所述电磁线圈和所述近红外照射模块。According to another aspect of the invention, the magnet is an electromagnetic coil, and the control module is coupled to the electromagnetic coil to control the electromagnetic coil and the near infrared illumination module.
根据本发明的另一个方面，所述近红外照射模块设置的位置对应于用户大脑的颞叶、额叶、顶叶、枕叶以及海马结构中的一个或多个。In accordance with another aspect of the invention, the near infrared illumination module is positioned to correspond to one or more of a temporal, frontal, parietal, occipital, and hippocampal formation of a user's brain.
根据本发明的另一个方面，包括多个磁体和多个近红外照射模块，所述多个磁体与所述多个近红外照射模块在同一平面内穿插排列，或所述磁***于近红外照射模块的前面，或所述磁***于近红外照射模块的后面。According to another aspect of the present invention, a plurality of magnets and a plurality of near-infrared illumination modules are interposed in a same plane as the plurality of near-infrared illumination modules, or the magnets are located in a near-infrared illumination module The front face, or the magnet is located behind the near infrared illumination module.
根据本发明的另一个方面，所述治疗装置还包括散热风扇，所述散热风扇靠近所述近红外照射模块设置。According to another aspect of the invention, the treatment device further includes a heat dissipation fan disposed adjacent to the near infrared illumination module.
根据本发明的另一个方面，所述近红外照射模块包括多个近红外发光二极管以及覆盖所述多个近红外发光二极管的透明板，所述近红外发光二极管发射的近红外波长为780-2526nm，照射模式分为连续光照射或脉冲光照射。According to another aspect of the present invention, the near-infrared illumination module includes a plurality of near-infrared light emitting diodes and a transparent plate covering the plurality of near-infrared light emitting diodes, and the near-infrared light emitting diode emits a near-infrared wavelength of 780-2526 nm. The illumination mode is divided into continuous light irradiation or pulsed light irradiation.
根据本发明的另一个方面，所述控制模块可调节所述近红外照射模块的照射强度和/或供应给所述电磁线圈的电流。According to another aspect of the invention, the control module can adjust an illumination intensity of the near infrared illumination module and/or a current supplied to the electromagnetic coil.
根据本发明的另一个方面，所述磁性模块的形状为圆形、椭圆形或者“8”字形。According to another aspect of the invention, the magnetic module is circular, elliptical or "8" shaped.
根据本发明的另一个方面，所述近红外照射模块设置在对应于患者的眼部、额头、太阳穴、后脑处，和/或所述磁***于使用者头部上半部。According to another aspect of the invention, the near infrared illumination module is disposed at an eye, a forehead, a temple, a hindbrain corresponding to a patient, and/or the magnet is located in an upper half of the user's head.
根据本发明的另一个方面，所述头部治疗装置为阿尔兹海默症治疗装置。According to another aspect of the invention, the head treatment device is an Alzheimer's disease treatment device.
本发明还提供一种治疗设备，包括：座椅部；如上所述的治疗装置，其中所述治疗装置连接到所述座椅部；和认知锻炼装置，所述认知锻炼装置连接到所述座椅部；和控制台，设置在所述座椅部上，与所述治疗装置和所述认知锻炼装置电连接以控制所述治疗装置和所述认知锻炼装置。The present invention also provides a treatment apparatus comprising: a seat portion; the treatment device as described above, wherein the treatment device is coupled to the seat portion; and a cognitive exercise device, the cognitive exercise device being coupled to the a seat portion; and a console disposed on the seat portion, electrically coupled to the treatment device and the cognitive exercise device to control the treatment device and the cognitive exercise device.
附图说明DRAWINGS
附图用来提供对本发明的进一步理解，并且构成说明书的一部分，与本发明的实施例一起用于解释本发明，并不构成对本发明的限制。在附图中：The drawings are intended to provide a further understanding of the invention, and are intended to be a In the drawing:
图1是根据本发明的一个实施例的头部治疗装置的结构示意图；1 is a schematic structural view of a head treatment device according to an embodiment of the present invention;
图2是根据本发明的一个实施例的头部治疗装置从上方观察的立体图；Figure 2 is a perspective view of the head treatment device as viewed from above, in accordance with one embodiment of the present invention;
图3是根据本发明的一个实施例的头部治疗装置从下方观察的立体图；Figure 3 is a perspective view of the head treatment device as viewed from below, in accordance with one embodiment of the present invention;
图4是根据本发明的一个实施例的磁性模块和近红外照射模块布置示意图；4 is a schematic view showing the arrangement of a magnetic module and a near-infrared illumination module according to an embodiment of the present invention;
图5A和5B示出了根据本发明的治疗装置1的治疗效果；5A and 5B illustrate the therapeutic effects of the treatment device 1 according to the present invention;
图6示出了根据本发明另一个实施例的治疗设备；和Figure 6 shows a treatment device in accordance with another embodiment of the present invention;
图7示出了根据本发明另一个实施例的治疗设备的逻辑图。Figure 7 shows a logic diagram of a treatment device in accordance with another embodiment of the present invention.
具体实施方式detailed description
在下文中，仅简单地描述了某些示例性实施例。正如本领域技术人员可认识到的那样，在不脱离本发明的精神或范围的情况下，可通过各种不同方式修改所描述的实施例。因此，附图和描述被认为本质上是示例性的而非限制性的。In the following, only certain exemplary embodiments are briefly described. The described embodiments may be modified in various different ways, without departing from the spirit and scope of the invention. Accordingly, the drawings and description are to be regarded as illustrative rather
在本发明的描述中，需要理解的是，术语"中心"、"纵向"、"横向"、"长度"、"宽度"、"厚度"、"上"、"下"、"前"、"后"、"左"、"右"、"坚直"、"水平"、"顶"、"底"、"内"、"外"、"顺时针"、"逆时针"等指示的方位或位置关系为基于附图所示的方位或位置关系，仅是为了便于描述本发明和简化描述，而不是指示或暗示所指的装置或元件必须具有特定的方位、以特定的方位构造和操作，因此不能理解为对本发明的限制。此外，术语"第一"、"第二"仅用于描述目的，而不能理解为指示或暗示相对重要性或者隐含指明所指示的技术特征的数量。由此，限定有"第一"、"第二"的特征可以明示或者隐含地包括一个或者更多个所述特征。在本发明的描述中，"多个"的含义是两个或两个以上，除非另有明确具体的限定。In the description of the present invention, it is to be understood that the terms "center", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "pre", " Directions such as "," "left", "right", "straight", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise", etc. The positional relationship is based on the orientation or positional relationship shown in the drawings, and is merely for the convenience of the description of the present invention and the simplified description, and is not intended to indicate or imply that the device or component referred to has a specific orientation, and is constructed and operated in a specific orientation. Therefore, it should not be construed as limiting the invention. Moreover, the terms "first" and "second" are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, features defining "first" or "second" may include one or more of the described features, either explicitly or implicitly. In the description of the present invention, the meaning of "plurality" is two or more unless specifically and specifically defined.
在本发明的描述中，需要说明的是，除非另有明确的规定和限定，术语" 安装"、"相连"、"连接"应做广义理解，例如，可以是固定连接，也可以是可拆卸连接，或一体地连接:可以是机械连接，也可以是电连接或可以相互通讯；可以是直接相连，也可以通过中间媒介间接相连，可以是两个元件内部的连通或两个元件的相互作用关系。对于本领域的普通技术人员而言，可以根据具体情况理解上述术语在本发明中的具体含义。In the description of the present invention, it should be noted that the terms "installation", "connected", and "connected" are to be understood broadly, and may be fixed or detachable, unless otherwise explicitly defined and defined. Connection, or integral connection: it can be mechanical connection, electrical connection or communication with each other; it can be directly connected or indirectly connected through an intermediate medium, which can be the internal connection of two elements or the interaction of two elements. relationship. For those skilled in the art, the specific meanings of the above terms in the present invention can be understood on a case-by-case basis.
在本发明中，除非另有明确的规定和限定，第一特征在第二特征之"上"或之"下"可以包括第一和第二特征直接接触，也可以包括第一和第二特征不是直接接触而是通过它们之间的另外的特征接触。而且，第一特征在第二特征"之上"、"上方"和"上面"包括第一特征在第二特征正上方和斜上方，或仅仅表示第一特征水平高度高于第二特征。第一特征在第二特征"之下"、"下方"和"下面"包括第一特征在第二特征正上方和斜上方，或仅仅表示第一特征水平高度小于第二特征。In the present invention, the first feature "on" or "under" the second feature may include direct contact of the first and second features, and may also include first and second features, unless otherwise explicitly defined and defined. It is not in direct contact but through additional features between them. Moreover, the first feature "above", "above" and "above" the second feature includes the first feature directly above and above the second feature, or merely indicating that the first feature level is higher than the second feature. The first feature "below", "below" and "below" the second feature includes the first feature directly above and above the second feature, or merely indicating that the first feature level is less than the second feature.
下文的公开提供了许多不同的实施方式或例子用来实现本发明的不同结构。为了简化本发明的公开，下文中对特定例子的部件和设置进行描述。当然，它们仅仅为示例，并且目的不在于限制本发明。此外，本发明可以在不同例子中重复参考数字和/或参考字母，这种重复是为了简化和清楚的目的，其本身不指示所讨论各种实施方式和/或设置之间的关系。此外，本发明提供了的各种特定的工艺和材料的例子，但是本领域普通技术人员可以意识到其他工艺的应用和/或其他材料的使用。The following disclosure provides many different embodiments or examples for implementing different structures of the present invention. In order to simplify the disclosure of the present invention, the components and arrangements of the specific examples are described below. Of course, they are merely examples and are not intended to limit the invention. In addition, the present invention may be repeated with reference to the numerals and/or reference numerals in the various examples, which are for the purpose of simplicity and clarity, and do not indicate the relationship between the various embodiments and/or arrangements discussed. Moreover, the present invention provides examples of various specific processes and materials, but one of ordinary skill in the art will recognize the use of other processes and/or the use of other materials.
以下结合附图对本发明的优选实施例进行说明，应当理解，此处所描述的优选实施例仅用于说明和解释本发明，并不用于限定本发明。The preferred embodiments of the present invention are described with reference to the accompanying drawings, which are intended to illustrate and illustrate the invention.
如图1-3所示，本发明的第一实施例提供一种可戴在头部的治疗装置1，例如用于治疗阿尔兹海默症。该治疗装置是一种光磁一体化装置。As shown in Figures 1-3, a first embodiment of the present invention provides a treatment device 1 that can be worn on the head, for example, for treating Alzheimer's disease. The treatment device is a photomagnetic integrated device.
下面参考图1-3详细描述该治疗装置1。如图1所示，本发明的治疗装置1包括近红外照射模块8以及磁性模块7(即经颅磁刺激模块)。近红外光源照射主要用于降低β-淀粉样蛋白的斑块形成，减少对神经***的损害。另外，磁性模块主要用于刺激阿尔兹海默症发病区域的神经***，增强神经的活性,促进神经修复。这两个模块都具有提高脑血容量的功能，这能够保证在 神经修复的过程中需要的血供。该装置主要从以上三个方面***地提高对于阿尔兹海默症的治疗效果。同时，近红外照射模块8以及磁性模块7之间相互协调、相互配合，例如先使近红外照射模块8发射短波长780nm的近红外光照射数分钟后，由磁性模块7以一个高频如1Hz频率的电磁波对脑部神经进行数分钟的刺激，使神经兴奋性增加。交替数次后可调整近红外的波长使其在780-2526nm之间变化，而磁性模块7也可以用高达20Hz或以上的频率对脑部神经进行刺激。这其中在长时间使用高频磁刺激的时候有些患者会出现头痛的症状，为了避免这种情况的出现但又不降低疗效，本装置用近红外照射和电磁刺激交替进行的方法达到最好的治疗效果。The treatment device 1 will be described in detail below with reference to Figs. 1-3. As shown in Figure 1, the treatment device 1 of the present invention includes a near infrared illumination module 8 and a magnetic module 7 (i.e., a transcranial magnetic stimulation module). Near-infrared light source illumination is mainly used to reduce plaque formation of β-amyloid and reduce damage to the nervous system. In addition, the magnetic module is mainly used to stimulate the nervous system in the area of Alzheimer's disease, enhance the activity of nerves, and promote nerve repair. Both modules have the ability to increase cerebral blood volume, which ensures the blood supply needed during nerve repair. The device systematically improves the therapeutic effect on Alzheimer's disease from the above three aspects. At the same time, the near-infrared illumination module 8 and the magnetic module 7 are coordinated and cooperate with each other. For example, after the near-infrared illumination module 8 emits short-wavelength 780 nm near-infrared light for several minutes, the magnetic module 7 has a high frequency such as 1 Hz. The electromagnetic waves of the frequency stimulate the brain nerves for several minutes, which increases the excitability of the nerves. After several alternations, the near-infrared wavelength can be adjusted to vary between 780 and 2526 nm, and the magnetic module 7 can also stimulate the brain nerves at frequencies up to 20 Hz or higher. In some cases, when some patients use high-frequency magnetic stimulation for a long time, some patients may have symptoms of headache. In order to avoid this situation without reducing the curative effect, the device achieves the best by alternating the method of near-infrared irradiation and electromagnetic stimulation. treatment effect.
图2和图3分别示出了本发明的治疗装置1的立体图，其中图2是从上方观察的立体图，图3是从下方观察的立体图。2 and 3 respectively show perspective views of the treatment device 1 of the present invention, wherein Fig. 2 is a perspective view from above, and Fig. 3 is a perspective view from below.
如图2和图3所示，本发明的治疗装置1包括外壳2。外壳2例如大致是头盔的形状，能够基本包覆佩戴者的头部。外壳2具有内部空腔，内部空腔的形状基本与佩戴者的头部相匹配。外壳2的尺寸优选的可以调节，从而适应不同的患者需求。As shown in Figures 2 and 3, the treatment device 1 of the present invention includes a housing 2. The outer casing 2 is, for example, substantially in the shape of a helmet that can substantially cover the wearer's head. The outer casing 2 has an internal cavity that is substantially shaped to match the wearer's head. The size of the outer casing 2 is preferably adjustable to accommodate different patient needs.
磁性模块7和近红外照射模块8分别设置在外壳2上，例如设置在外壳2的内壁上，用于对佩戴本发明治疗装置1的患者头部施加治疗或理疗。优选的，所述的近红外光照射模块8和磁性模块7通过连接元件可张开收拢地设置在外壳2内部。例如在治疗装置1不使用时，近红外光照射模块8和磁性模块7收拢设置在治疗装置1内。当患者佩戴上治疗装置1时，近红外光照射模块8和磁性模块7在外壳2内适当张开，以更接近患者的头部。The magnetic module 7 and the near-infrared illumination module 8 are respectively disposed on the outer casing 2, for example, on the inner wall of the outer casing 2 for applying treatment or physical therapy to the head of the patient wearing the treatment device 1 of the present invention. Preferably, the near-infrared light illumination module 8 and the magnetic module 7 are disposed inside the outer casing 2 so as to be openable and contracted by the connecting member. For example, when the treatment device 1 is not in use, the near-infrared light irradiation module 8 and the magnetic module 7 are gathered and disposed in the treatment device 1. When the patient wears the treatment device 1, the near-infrared light illumination module 8 and the magnetic module 7 are properly opened within the outer casing 2 to be closer to the patient's head.
所述磁性模块7例如为永磁体。优选的，所述磁性模块7为电磁线圈。通过调整通过电磁线圈的电流强度，可以调节穿透的磁力、强度和磁场方向等，以适应不同的病变部位治疗需求。The magnetic module 7 is for example a permanent magnet. Preferably, the magnetic module 7 is an electromagnetic coil. By adjusting the current intensity through the electromagnetic coil, the magnetic force, intensity and magnetic field direction of the penetration can be adjusted to suit the treatment needs of different lesions.
优选的，所述治疗装置1还包括控制单元(未示出)，用于控制所述磁性模块7和/或所述近红外光照射模块8的工作。所述控制单元例如可以设置在外壳2上，也可以是单独的控制手柄，与所述近红外光照射模块8和/或磁性模块7电耦合，以利于用户操作。所述控制单元例如控制所述磁性模块7的 磁力、强度和磁场方向以及变化频率，以及所述近红外光照射模块8的照射强度和波长。Preferably, the treatment device 1 further comprises a control unit (not shown) for controlling the operation of the magnetic module 7 and/or the near-infrared light illumination module 8. The control unit can be arranged, for example, on the housing 2, or it can be a separate control handle, electrically coupled to the near-infrared illumination module 8 and/or the magnetic module 7 to facilitate user operation. The control unit controls, for example, the magnetic force, the intensity and the direction of the magnetic field and the frequency of change of the magnetic module 7, as well as the illumination intensity and wavelength of the near-infrared light illumination module 8.
如图2和3所示，所述近红外光照射模块8包括照射模块外壳9、近红外发光二极管阵列10、散热风扇11。该近红外光照射模块8的位置至少对应于患者大脑的颞叶、额叶、顶叶、枕叶以及海马结构中的一个或多个，从而对这些部位进行照射，但并不仅限于这些部位。近红外发光二极管在工作状态下，发射的近红外波长主要集中在780-2526nm。光照模式可以为连续光照射或者脉冲光照射。近红外照射二极管阵列10前覆盖有透明的照射模块外壳9，以防止人头部皮肤接触近红外发光二极管灯珠而对人体造成危害，近红外光照射模块后部的散热风扇11，可对近红外发光二极管进行散热。在工作状态下，控制的单元的控制电路或控制逻辑根据预设的光照强度等参数分别控制各个一个或多个近红外光照射模块8中的近红外发光二极管的照射强度。在实际治疗过程中，可以根据患者的实际情况，分别设定各个近红外光照射模块8上近红外发光二极管的光照强度等参数，即各个近红外光照射模块8上近红外发光二极管的光照强度等可单独控制。As shown in FIGS. 2 and 3, the near-infrared light illumination module 8 includes an illumination module housing 9, a near-infrared light emitting diode array 10, and a heat dissipation fan 11. The position of the near-infrared light illumination module 8 corresponds at least to one or more of the temporal, frontal, parietal, occipital, and hippocampal structures of the patient's brain to illuminate, but is not limited to, these locations. In the working state, the near-infrared wavelength of the near-infrared light-emitting diode is mainly concentrated at 780-2526 nm. The illumination mode can be continuous light or pulsed light. The near-infrared illumination diode array 10 is covered with a transparent illumination module casing 9 to prevent the human head skin from contacting the near-infrared light-emitting diode lamp bead and causing harm to the human body. The near-infrared light illuminating module the rear cooling fan 11 can be close to Infrared LEDs dissipate heat. In the working state, the control circuit or control logic of the controlled unit controls the illumination intensity of the near-infrared light-emitting diodes in each of the one or more near-infrared light illumination modules 8 according to parameters such as preset illumination intensity. In the actual treatment process, according to the actual situation of the patient, the parameters such as the light intensity of the near-infrared light-emitting diodes on each of the near-infrared light-irradiating modules 8 may be respectively set, that is, the light intensity of the near-infrared light-emitting diodes on each of the near-infrared light-irradiating modules 8 Etc. can be controlled separately.
磁性模块7的尺寸和几何形状可以被特殊设计成圆形、椭圆形或者是“8”字形等，数量也不限。刺激强度和刺激模式可以通过控制单元的控制电路或控制逻辑进行设定。该磁场可以向患者的特定大脑皮层部位实行磁刺激。而根据刺激部位和刺激深度的要求不同可进行调整。The size and geometry of the magnetic module 7 can be specially designed to be circular, elliptical or "8" shaped, etc., and the number is not limited. The stimulation intensity and stimulation mode can be set by the control circuit or control logic of the control unit. This magnetic field can perform magnetic stimulation to a specific cerebral cortex of a patient. The adjustment can be made according to the requirements of the stimulation site and the stimulation depth.
本发明中的治疗装置1中，近红外照射模块8和磁性模块7可以有多种排布方式，包括但不局限于磁性模块与近红外照射模块8在同一平面内穿插排列，或磁性模块位于近红外照射模块8的前面，或磁性模块位于近红外照射模块8的后面等。本发明的发明人发现，长时间持续刺激固定的脑区，其治疗效果会被弱化，刺激不同的脑区如背外侧前额叶皮层、Broca区或者刺激相同区域但是属于不同的脑半球会明显提高患者的认知能力。为了对于阿尔兹海默症的患者达到最好的治疗效果，将磁性模块7与近红外照射模块8在同一平面内设计了多种穿插排列的布局结构，可以取得最佳的治疗效果。In the treatment device 1 of the present invention, the near-infrared illumination module 8 and the magnetic module 7 can be arranged in various ways, including but not limited to, the magnetic module and the near-infrared illumination module 8 are interspersed in the same plane, or the magnetic module is located. The front side of the near-infrared illumination module 8, or the magnetic module is located behind the near-infrared illumination module 8, and the like. The inventors of the present invention have found that the therapeutic effect of the brain region which is continuously stimulated for a long time is weakened, and the stimulation of different brain regions such as the dorsolateral prefrontal cortex, the Broca region or the stimulation of the same region but belonging to different brain hemispheres is markedly improved. The cognitive ability of the patient. In order to achieve the best therapeutic effect for patients with Alzheimer's disease, the magnetic module 7 and the near-infrared illumination module 8 are designed in a variety of interspersed arrangement structures in the same plane, and the best therapeutic effect can be obtained.
图4示出了一种优选的磁性模块与近红外照射模块8的排布方式，但具 体的排布方式、模块数目并不局限于此。图4中共布置了10块近红外光照射模块，内嵌于治疗装置1的壳体2内部，其中在对应于眼部附近2块，额头附近2块，左右太阳穴附近2块，后脑附近4块。5块磁性模块位于使用者头部上半部分，通过弹簧装置与外壳连接,角度和长度可根据使用者的情况而调节。Fig. 4 shows a preferred arrangement of the magnetic module and the near-infrared illumination module 8, but the specific arrangement and the number of modules are not limited thereto. A total of 10 near-infrared light illumination modules are arranged in Fig. 4, which are embedded in the inside of the housing 2 of the treatment device 1, wherein there are 2 blocks near the eye, 2 near the forehead, 2 near the left and right temples, and 4 blocks near the hindbrain. . The five magnetic modules are located in the upper part of the user's head and are connected to the housing by spring means. The angle and length can be adjusted according to the user's condition.
在治疗过程中，为近红外光照射和电磁刺激设置了多种工作模式，两者可分别单独工作，也可以同时工作，也可以交替进行。其工作方式的选择可根据患者自身的情况而定。如：患者对电磁刺激反应强烈的话就可以适当的降低电磁刺激的强度或者频率，又或者可以变换刺激部位。又如根据头部检查结果发现脑内的β-淀粉样蛋白斑块无明显变化的话，可适当增加近红外光的刺激强度。也可以根据对患者认知能力的检查结果适当调整刺激时间和工作方式。In the course of treatment, a variety of working modes are set for near-infrared light irradiation and electromagnetic stimulation, and the two can work separately or simultaneously, or alternately. The choice of how to work can be based on the patient's own situation. For example, if the patient responds strongly to electromagnetic stimulation, the intensity or frequency of the electromagnetic stimulation can be appropriately reduced, or the stimulation site can be changed. For example, if the β-amyloid plaque in the brain is not significantly changed according to the results of the head examination, the stimulation intensity of near-infrared light can be appropriately increased. The stimulation time and working style can also be appropriately adjusted according to the examination results of the patient's cognitive ability.
本发明针对阿尔兹海默症的病因和临床病理表现，首次利用光磁一体化刺激装置在一次治疗中减少了β-淀粉样蛋白斑块沉积的同时又起到了兴奋神经元的作用。在治疗佩戴的头盔上也做了改良，把近红外光模块和磁刺激模块的位置做了最优化的排位。The invention aims at the etiology and clinicopathological manifestation of Alzheimer's disease, and the first use of the opto-magnetic integrated stimulation device reduces the deposition of β-amyloid plaque in one treatment and plays the role of excitatory neurons. Improvements have also been made to the helmet worn by the treatment to optimize the position of the near-infrared light module and the magnetic stimulation module.
图5A和5B示出了采用本发明的治疗装置1治疗阿尔兹海默症的效果。图5A中，使用经过基因改造的AD模型的小鼠为实验研究对象，在试验组(IR)小鼠的头部戴上根据本发明的可发射特定波长的近红外光头盔，而对照组(Sham)小鼠的头部仅带着无近红外发射模块的头盔。试验持续6个月后观察试验组和对照组在治疗前后脑部的β-淀粉样蛋白斑块的变化。在上面的图片中可见在脑皮质(cortex)部位β-淀粉样蛋白斑块的减少较其他部位如齿状回(dentate gyrus)、海马(hipoocampus)1区和2区明显得多。图5B显示出治疗组(AD+IR)的小鼠脑皮层平均斑块数量比对照组(AD)明显减少。此结果提示本实验中治疗后脑皮层的β类淀粉蛋白质斑块明显优于对照组。5A and 5B show the effect of treating the Alzheimer's disease using the treatment device 1 of the present invention. In Fig. 5A, a mouse using a genetically modified AD model was used as an experimental research subject, and a near-infrared light helmet capable of emitting a specific wavelength according to the present invention was worn on the head of a test group (IR) mouse, while the control group ( Sham) The head of the mouse is only carried with a helmet without a near-infrared emitting module. The changes of β-amyloid plaques in the brain of the test group and the control group before and after treatment were observed after 6 months of the test. In the above picture, it can be seen that the reduction of β-amyloid plaques in the cortex site is much more pronounced than in other sites such as dentate gyrus, hippocampus 1 and 2. Figure 5B shows that the average number of plaques in the cortex of the treated group (AD+IR) was significantly reduced compared to the control group (AD). This result suggests that the β-amyloid protein plaques in the cerebral cortex after treatment in this experiment are significantly better than the control group.
下面参考图6描述根据本发明另一个实施例的治疗设备100。治疗设备100包括本发明的治疗装置1。A treatment device 100 in accordance with another embodiment of the present invention is described below with reference to FIG. The treatment device 100 comprises the treatment device 1 of the invention.
如图6所示，治疗设备100包括座椅部12。座椅部12包括底座和靠背，用于使得患者能够舒适地坐于其上。治疗装置1例如可通过支架13安装在座椅部12上，其相对于座椅部12的位置和高度可以进行调节，以适应坐在座椅部12中的患者的佩戴需求。As shown in FIG. 6, the treatment device 100 includes a seat portion 12. The seat portion 12 includes a base and a backrest for enabling a patient to sit comfortably thereon. The treatment device 1 can be mounted, for example, on the seat portion 12 by a bracket 13 that can be adjusted relative to the position and height of the seat portion 12 to accommodate the wear requirements of the patient seated in the seat portion 12.
所述的座椅部12上例如还可在便于操作的位置处设有人机交互界面和电源开关，从而操作治疗设备1以及治疗装置1。根据本发明的一个实施方式，治疗装置1的控制单元，例如近红外光照射控制单元和电磁调节控制单元，可以设置在所述座椅部上，并且与所述治疗装置1的近红外光照射模块和磁性模块电连接以进行控制。The seat portion 12 can also be provided with a human-machine interface and a power switch, for example, at a position convenient for operation, thereby operating the treatment device 1 and the treatment device 1. According to an embodiment of the present invention, a control unit of the treatment device 1, such as a near-infrared light irradiation control unit and an electromagnetic adjustment control unit, may be disposed on the seat portion and irradiated with near-infrared light of the treatment device 1 The module and the magnetic module are electrically connected for control.
图6所示的治疗设备100还包括认知锻炼装置14。认知锻炼装置14设置在座椅部12的前部，面向坐在所述座椅部12上的患者。认知锻炼装置14可以通过支架15连接到座椅部。认知锻炼装置14例如是显示器，其上可以针对不同患者类型而显示认知锻炼的信息。The treatment device 100 shown in FIG. 6 also includes a cognitive exercise device 14. The cognitive exercise device 14 is disposed at the front of the seat portion 12 and faces the patient sitting on the seat portion 12. The cognitive exercise device 14 can be coupled to the seat portion by a bracket 15. The cognitive exercise device 14 is, for example, a display on which information about cognitive exercise can be displayed for different patient types.
所述治疗设备100还包括控制台16。控制台16例如通过数据线连接到所述治疗装置1和前部锻炼装置14，可控制所述治疗装置1的近红外光照射控制单元和电磁调节控制单元、以及所述前部认知锻炼装置14。因此所述治疗装置1的控制单元也可以集成到所述控制台16中。The treatment device 100 also includes a console 16. The console 16 is connected to the treatment device 1 and the front exercise device 14 by, for example, a data line, and the near-infrared light illumination control unit and the electromagnetic adjustment control unit of the treatment device 1 and the front cognitive exercise device can be controlled. 14. The control unit of the treatment device 1 can therefore also be integrated into the console 16.
图7示出了根据本发明的治疗设备100的逻辑图。其中，治疗设备100包括座椅部12、治疗装置1以及认知锻炼装置14。治疗设备100的主控电路设置在座椅部12上，通过控制台16为用户或医师提供操作接口。主控电路为治疗设备100的控制核心，其中存储有计算机程序或控制逻辑。其分别与所述治疗装置1的近红外照射模块和磁性模块以及认知锻炼装置单向或双向通信，以控制整个治疗过程。Figure 7 shows a logic diagram of a treatment device 100 in accordance with the present invention. Among them, the treatment device 100 includes a seat portion 12, a treatment device 1, and a cognitive exercise device 14. The main control circuit of the treatment device 100 is disposed on the seat portion 12 to provide an operational interface to the user or physician via the console 16. The master control circuit is the control core of the therapy device 100 in which computer programs or control logic are stored. It is unidirectionally or bidirectionally communicated with the near infrared illumination module and magnetic module of the treatment device 1 and the cognitive exercise device, respectively, to control the entire treatment process.
在使用过程中，用户通过控制台16的图形用户接口输入命令，主控电路接收到用户输入后，向治疗装置1和认知锻炼装置14发出指令，控制近红外照射强度、波长、磁刺激强度、以及认知锻炼装置14上所显示的内容，从而为坐在座椅部12上的患者提供治疗。During use, the user inputs a command through the graphical user interface of the console 16, and after receiving the user input, the main control circuit issues instructions to the treatment device 1 and the cognitive exercise device 14 to control the intensity, wavelength, and magnetic stimulation intensity of the near infrared radiation. And the content displayed on the cognitive exercise device 14 to provide treatment to the patient sitting on the seat portion 12.
以上是以阿尔兹海默症为例对本发明进行了说明。普通技术人员可以理 解，本发明的保护范围不限于此，可以适用于为其他病症的治疗。The present invention has been described above by taking Alzheimer's disease as an example. It will be understood by a person skilled in the art that the scope of protection of the present invention is not limited thereto and can be applied to the treatment of other conditions.
最后应说明的是：以上所述仅为本发明的优选实施例而已，并不用于限制本发明，尽管参照前述实施例对本发明进行了详细的说明，对于本领域的技术人员来说，其依然可以对前述各实施例所记载的技术方案进行修改，或者对其中部分技术特征进行等同替换。凡在本发明的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本发明的保护范围之内。It should be noted that the above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, although the present invention has been described in detail with reference to the foregoing embodiments, Modifications may be made to the technical solutions described in the foregoing embodiments, or some of the technical features may be equivalently replaced. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and scope of the present invention are intended to be included within the scope of the present invention.

Claims (11)

  1. 一种治疗装置，包括：A therapeutic device comprising:
    壳体，所述壳体可供用户穿戴在头部；a housing for the user to wear on the head;
    磁体，所述磁体安装在所述壳体上；a magnet mounted on the housing;
    近红外照射模块，所述近红外照射模块安装在所述壳体上并可朝所述壳体内部发射近红外照射；和a near-infrared illumination module mounted on the housing and capable of emitting near-infrared illumination toward the interior of the housing;
    控制模块，所述控制模块与所述近红外照射模块耦合从而控制所述近红外照射模块的工作。And a control module coupled to the near infrared illumination module to control operation of the near infrared illumination module.
  2. 根据权利要求1所述的治疗装置，其特征在于，所述磁体为电磁线圈，所述控制模块与所述电磁线圈耦合，控制所述电磁线圈和所述近红外照射模块，优选的，所述电磁线圈与所述近红外照射模块交替工作。The treatment device according to claim 1, wherein said magnet is an electromagnetic coil, said control module being coupled to said electromagnetic coil, controlling said electromagnetic coil and said near infrared illumination module, preferably said The electromagnetic coil alternates with the near infrared illumination module.
  3. 根据权利要求1或2所述的治疗装置，其特征在于，所述近红外照射模块设置的位置对应于用户大脑的颞叶、额叶、顶叶、枕叶以及海马结构中的一个或多个。The treatment device according to claim 1 or 2, wherein the near-infrared illumination module is disposed at a position corresponding to one or more of a temporal lobe, a frontal lobe, a parietal lobe, a occipital lobe, and a hippocampal formation of a user's brain. .
  4. 根据权利要求1-3中任一项所述的治疗装置，其特征在于，包括多个磁体和多个近红外照射模块，所述多个磁体与所述多个近红外照射模块在同一平面内穿插排列，或所述磁***于近红外照射模块的前面，或所述磁***于近红外照射模块的后面。The treatment device according to any one of claims 1 to 3, comprising a plurality of magnets and a plurality of near-infrared illumination modules, the plurality of magnets being in the same plane as the plurality of near-infrared illumination modules Interspersed, or the magnet is located in front of the near infrared illumination module, or the magnet is located behind the near infrared illumination module.
  5. 根据权利要求1-4中任一项所述的治疗装置，其特征在于，所述治疗装置还包括散热风扇，所述散热风扇靠近所述近红外照射模块设置。The treatment device according to any one of claims 1 to 4, wherein the treatment device further comprises a heat dissipation fan disposed adjacent to the near-infrared illumination module.
  6. 根据权利要求1-5中任一项所述的治疗装置，其特征在于，所述近红外照射模块包括多个近红外发光二极管以及覆盖所述多个近红外发光二极管的透明板，所述近红外发光二极管发射的近红外波长为780-2526nm，照射模式分为连续光照射或脉冲光照射。The treatment device according to any one of claims 1 to 5, wherein the near-infrared illumination module comprises a plurality of near-infrared light-emitting diodes and a transparent plate covering the plurality of near-infrared light-emitting diodes, the near The near-infrared wavelength emitted by the infrared light emitting diode is 780-2526 nm, and the illumination mode is divided into continuous light irradiation or pulsed light irradiation.
  7. 根据权利要求2所述的治疗装置，其特征在于，所述控制模块可调节所述近红外照射模块的照射强度、波长和/或供应给所述电磁线圈的电流。The treatment device according to claim 2, wherein the control module adjusts an illumination intensity, a wavelength, and/or a current supplied to the electromagnetic coil of the near-infrared illumination module.
  8. 根据权利要求1-7中任一项所述的治疗装置，其特征在于，所述磁性模块的形状为圆形、椭圆形或者“8”字形。The treatment device according to any one of claims 1 to 7, wherein the magnetic module has a circular, elliptical or "8" shape.
  9. 根据权利要求1-8中任一项所述的治疗装置，其特征在于，所述头部治疗装置为阿尔兹海默症治疗装置。The treatment device according to any one of claims 1-8, wherein the head treatment device is an Alzheimer's disease treatment device.
  10. 根据权利要求1-9中任一项所述的治疗装置，其特征在于，所述近红外照射模块设置在对应于患者的眼部、额头、太阳穴、后脑处，和/或所述磁***于使用者头部上半部。The treatment device according to any one of claims 1 to 9, wherein the near-infrared illumination module is disposed at an eye, a forehead, a temple, a hindbrain corresponding to a patient, and/or the magnet is in use The upper part of the head.
  11. 一种治疗设备，包括：A therapeutic device comprising:
    座椅部；Seat portion
    如权利要求1-10中任一项所述的治疗装置，其中所述治疗装置连接到所述座椅部；The treatment device according to any one of claims 1 to 10, wherein the treatment device is coupled to the seat portion;
    认知锻炼装置，所述认知锻炼装置连接到所述座椅部；和a cognitive exercise device connected to the seat portion; and
    控制台，设置在所述座椅部上，与所述治疗装置和所述认知锻炼装置电连接以控制所述治疗装置和所述认知锻炼装置。A console, disposed on the seat portion, is electrically coupled to the treatment device and the cognitive exercise device to control the treatment device and the cognitive exercise device.
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