WO2018198101A3 - Processes for the preparation of crystalline form of eluxadoline - Google Patents
Processes for the preparation of crystalline form of eluxadoline Download PDFInfo
- Publication number
- WO2018198101A3 WO2018198101A3 PCT/IB2018/053134 IB2018053134W WO2018198101A3 WO 2018198101 A3 WO2018198101 A3 WO 2018198101A3 IB 2018053134 W IB2018053134 W IB 2018053134W WO 2018198101 A3 WO2018198101 A3 WO 2018198101A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- eluxadoline
- processes
- preparation
- crystalline form
- relates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
The present invention relates to processes for the preparation of a crystalline form of eluxadoline.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN201711014592 | 2017-04-25 | ||
| IN201711014592 | 2017-04-25 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2018198101A2 WO2018198101A2 (en) | 2018-11-01 |
| WO2018198101A3 true WO2018198101A3 (en) | 2019-05-16 |
Family
ID=63920194
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/IB2018/053134 WO2018198101A2 (en) | 2017-04-25 | 2018-05-04 | Processes for the preparation of crystalline form of eluxadoline |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2018198101A2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10314819B2 (en) | 2015-07-23 | 2019-06-11 | Teva Pharmaceuticals International Gmbh | Solid state forms of Eluxadoline |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009009480A2 (en) * | 2007-07-09 | 2009-01-15 | Janssen Pharmaceutica N.V. | Novel crystals and process of making 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy- benzoic acid |
| WO2017015606A1 (en) * | 2015-07-23 | 2017-01-26 | Teva Pharmaceuticals International Gmbh | Solid state forms of eluxadoline |
| WO2017153471A1 (en) * | 2016-03-11 | 2017-09-14 | Euticals S.P.A. | New stable solvate crystalline forms of eluxadolina |
| WO2017221213A1 (en) * | 2016-06-23 | 2017-12-28 | Sun Pharmaceutical Industries Limited | Processes for the preparation of eluxadoline |
| US20180029994A1 (en) * | 2015-02-23 | 2018-02-01 | Allergan Holdings Unlimited Company | Process for the preparation of intermediates useful in the synthesis of eluxadoline |
| WO2018046028A1 (en) * | 2016-09-07 | 2018-03-15 | Zentiva, K.S. | Solid forms of eluxadoline |
-
2018
- 2018-05-04 WO PCT/IB2018/053134 patent/WO2018198101A2/en active Application Filing
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009009480A2 (en) * | 2007-07-09 | 2009-01-15 | Janssen Pharmaceutica N.V. | Novel crystals and process of making 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy- benzoic acid |
| US20140011851A1 (en) * | 2007-07-09 | 2014-01-09 | Furiex Pharmaceuticals, Inc. | Novel crystals and process of making 5-(-METHYL)-2-METHOXY-BENZOIC ACID |
| US20180029994A1 (en) * | 2015-02-23 | 2018-02-01 | Allergan Holdings Unlimited Company | Process for the preparation of intermediates useful in the synthesis of eluxadoline |
| WO2017015606A1 (en) * | 2015-07-23 | 2017-01-26 | Teva Pharmaceuticals International Gmbh | Solid state forms of eluxadoline |
| WO2017153471A1 (en) * | 2016-03-11 | 2017-09-14 | Euticals S.P.A. | New stable solvate crystalline forms of eluxadolina |
| WO2017221213A1 (en) * | 2016-06-23 | 2017-12-28 | Sun Pharmaceutical Industries Limited | Processes for the preparation of eluxadoline |
| WO2018046028A1 (en) * | 2016-09-07 | 2018-03-15 | Zentiva, K.S. | Solid forms of eluxadoline |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2018198101A2 (en) | 2018-11-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2014375265A1 (en) | Novel pyrazolyl-heteroarylamides as pesticides | |
| WO2015195656A3 (en) | Synthesis of polycyclic-carbamoylpyridone compounds | |
| MX2019000664A (en) | Preparation of 14-methyl-16-oxabicyclo[10.3.1]pentadecenes from 3-methyl-1,5-cyclopentadecanedione. | |
| EP3630738A4 (en) | Process for the production of ozanimod | |
| AU2015339087B2 (en) | Trifluoromethyl alcohols as modulators of RORyt | |
| EP3694499A4 (en) | Novel process for the preparation of lifitegrast | |
| WO2016009401A3 (en) | Preparation of tedizolid phosphate | |
| EP3717457A4 (en) | Process for preparation of enzalutamide using novel intermediate | |
| EP3720845A4 (en) | Processes to produce elagolix | |
| MX2017011389A (en) | Process for preparing 3-chloro-2-vinylphenylsulfonates. | |
| MX2019004182A (en) | Process for the manufacture of 2,6-dimethyl-5-hepten-1-al. | |
| PH12018500872A1 (en) | Innovative preparation and crystallization of iosimenol | |
| MX2016015624A (en) | Process for preparing thiazole derivatives. | |
| MX2019004024A (en) | Method for producing cyclopropyl-substituted acetophenones. | |
| MX2021004996A (en) | Preparation of 2-substituted 4-methyl-tetrahydropyrans from 2-substituted 4-hydroxy-4-methyl-tetrahydropyrans as starting materials. | |
| WO2014118606A3 (en) | A novel process for the preparation of silodosin | |
| EP3793980A4 (en) | Crystalline form of s-apomorphine | |
| EP3727377A4 (en) | Process for the preparation of pyrimidinyl-4-aminopyrazole compounds | |
| EP3459933A3 (en) | Solid forms of a pharmaceutically active compound | |
| EP3706740A4 (en) | Processes to produce acalabrutinib | |
| WO2018198101A3 (en) | Processes for the preparation of crystalline form of eluxadoline | |
| MX2020006006A (en) | Crystal forms. | |
| WO2015118558A3 (en) | Process for the preparation of clofarabine | |
| MX2016016398A (en) | Preparation of piperidine-4-carbothioamide. | |
| TN2017000065A1 (en) | A tetrahydropyrrolo[3,4-d][1,3]thiazine-derivative as bace inhibitor |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 18791521 Country of ref document: EP Kind code of ref document: A2 |
|
| NENP | Non-entry into the national phase |
Ref country code: DE |
|
| 122 | Ep: pct application non-entry in european phase |
Ref document number: 18791521 Country of ref document: EP Kind code of ref document: A2 |