WO2018174050A1 - Mixing assistance tool and syringe system - Google Patents

Mixing assistance tool and syringe system Download PDF

Info

Publication number
WO2018174050A1
WO2018174050A1 PCT/JP2018/010994 JP2018010994W WO2018174050A1 WO 2018174050 A1 WO2018174050 A1 WO 2018174050A1 JP 2018010994 W JP2018010994 W JP 2018010994W WO 2018174050 A1 WO2018174050 A1 WO 2018174050A1
Authority
WO
WIPO (PCT)
Prior art keywords
syringe
base end
barrel
mixing aid
finger
Prior art date
Application number
PCT/JP2018/010994
Other languages
French (fr)
Japanese (ja)
Inventor
沖原等
Original Assignee
テルモ株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by テルモ株式会社 filed Critical テルモ株式会社
Priority to JP2019507686A priority Critical patent/JP6975226B2/en
Publication of WO2018174050A1 publication Critical patent/WO2018174050A1/en

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/45—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads
    • B01F25/451—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by means for moving the materials to be mixed or the mixture
    • B01F25/4512—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by means for moving the materials to be mixed or the mixture with reciprocating pistons

Definitions

  • the present invention relates to a mixing aid and a syringe system used when mixing medicines in two syringes.
  • a syringe kit for mixing two drugs for mixing drugs in two syringes is known (for example, see JP2013-132349A).
  • this type of syringe kit in order to mix the drugs in the two syringes, the barrels of the two syringes are connected to each other, and the pusher of one syringe is pushed, so Is transferred to the barrel of the other syringe.
  • the drug when transferring the drug from one barrel to the other, the drug cannot be transferred due to the resistance of the gasket in the other barrel, or the transfer takes time. There is. In particular, in the case of a powder with a lot of air in the syringe, the buffer due to the compression of air is large, and it takes time to shift.
  • the present invention has been made in consideration of such problems, and an object thereof is to provide a mixing aid and a syringe system capable of shortening the mixing time of a medicine using a syringe kit.
  • the present invention provides a mixing aid that can be attached to a syringe kit including two syringes whose tip portions can be connected to each other in order to mix a medicine,
  • a syringe kit including two syringes whose tip portions can be connected to each other in order to mix a medicine,
  • Each has a barrel having a finger grip projecting radially outward at the proximal end, a gasket slidably disposed within the barrel, and a pusher proximal end connected to the gasket and at the proximal end A pusher protruding in the proximal direction from the proximal end opening of the barrel, the finger grip is formed in a non-circular shape having a short axis and a long axis, and the two auxiliary syringes are connected to each other.
  • 2 mounting portions, and a rod-shaped connecting portion that connects the first mounting portion and the second mounting portion, and the width of the connecting portion in the direction perpendicular to the longitudinal direction of the mixing aid is The finger grip is smaller than the length of the finger grip along the long axis, and the one and the other pusher base end portions are respectively attached to the first attachment portion and the second attachment portion. It protrudes outward from the connecting portion.
  • the pushers of the two syringes are connected to each other by the mixing aid. Therefore, when an operation of pushing one pusher in the distal direction is performed, the other pusher is simultaneously performed. The operation of pulling in the proximal direction occurs. Thereby, the medicine can be transferred smoothly and the mixing time can be shortened. Further, even when air is contained in the syringe, the air is not compressed during mixing, and smooth mixing is possible. Furthermore, since the mixing can be performed by pressing the pusher as in the case where the mixing aid is not used, the mixing can be performed with the same operation feeling.
  • the connecting portion includes two connecting members extending opposite to each other, and one end side of each of the two connecting members is connected to the first mounting portion, and each of the two connecting members The other end side is connected to the second mounting portion, and the syringe kit is disposed between the two connecting members in a state where the connected syringe kit is mounted on the mixing aid. May be.
  • This configuration suppresses deformation of the connecting portion during the mixing operation, so that the drug can be transferred more smoothly.
  • the first mounting part and the second mounting part include a finger support part that supports the base end surface of the pusher base end part and is pressed with a finger, and the length of the mixing assisting tool of the finger support part
  • the width in the direction perpendicular to the direction may be larger than the diameter of the pusher base end and smaller than the length of the finger grip along the major axis.
  • the finger holder since the finger holder has an appropriate size, it is easy to press the pusher by placing a finger on the finger holder when performing a mixing operation.
  • the mixing aid may be deformable into a first form in which the syringe kit in a connected state can be mounted and a second form having a shorter overall length than the first form.
  • This configuration allows the second form to be stored compactly before using the mixing aid. Moreover, after use, it can be changed into a 2nd form from a 1st form, and can be discarded compactly.
  • the connecting portion includes a first member having the first mounting portion and a second member having the second mounting portion, and the first member and the second member rotate with each other via a hinge portion. It may be movably connected.
  • the present invention provides a syringe kit including two syringes whose tip portions can be connected to each other in order to mix a drug and a syringe kit in which the two syringes are connected to each other.
  • Each of the two syringes is connected to the gasket, a barrel having a finger grip at a proximal end, a gasket slidably disposed in the barrel, and a syringe system.
  • the mixing assisting tool includes a first mounting portion on which one of the pusher base end portions of the syringe kit in the connected state can be mounted, and the other of the syringe kit in the connected state.
  • the width in the direction perpendicular to the direction is smaller than the length of the pusher base end portion along the major axis, and one and the other pusher base end portions are provided on the first mounting portion and the second mounting portion.
  • the finger grip protrudes outward from the connecting portion in a mounted state.
  • the connecting portion includes two connecting members extending opposite to each other, and one end side of each of the two connecting members is connected to the first mounting portion, and the two The other end side of each connecting member is connected to the second mounting part, and the syringe kit is connected to the two connecting members in a state where the connected syringe kit is mounted to the mixing aid. It may be arranged between.
  • This configuration suppresses deformation of the connecting portion during the mixing operation, so that the drug can be transferred more smoothly.
  • the first mounting portion and the second mounting portion include a finger support portion that supports a base end surface of the pusher base end portion and is pressed with a finger
  • the finger support portion includes: The width in the direction perpendicular to the longitudinal direction of the mixing aid may be larger than the diameter of the pusher base end portion and smaller than the length of the finger grip along the major axis.
  • the finger holder since the finger holder has an appropriate size, it is easy to press the pusher by placing a finger on the finger holder when performing a mixing operation.
  • the mixing aid may be deformable into a first form in which the connected syringe kit can be mounted and a second form in which the overall length is shorter than that in the first form.
  • This configuration allows the second form to be stored compactly before using the mixing aid. Moreover, after use, it can be changed into a 2nd form from a 1st form, and can be discarded compactly.
  • the connecting portion includes a first member having the first mounting portion and a second member having the second mounting portion, and the first member and the second member are hinge portions. It may be connected so that rotation is possible mutually.
  • air in the initial state of the syringe kit, air may be contained in the filling space formed on the tip side of the gasket in the barrel of at least one of the two syringes.
  • a tip of the barrel of the two syringes is provided with a screwing projection that can be screwed together, and a flange that protrudes radially outward is provided at the base end of the barrel.
  • the finger grip provided may be a grip member attached to the flange portion so as to be rotatable about an axis of the barrel.
  • the finger grip can be easily and reliably protruded outside the connecting portion regardless of the screwing state of the screwing protrusion.
  • the mixing aid and syringe system of the present invention it is possible to shorten the mixing time of the medicine using the syringe kit.
  • FIG. 1 is a perspective view of a syringe system according to a first embodiment of the present invention. It is a perspective view of a syringe kit (before connection). It is a top view of the syringe system shown in FIG. FIG. 4 is a sectional view taken along line IV-IV in FIG. 3. It is a perspective view of a syringe kit (after connection). It is explanatory drawing when the length of a syringe kit and a mixing aid differs. It is a perspective view of the syringe system which concerns on 2nd Embodiment of this invention. It is a perspective view of the state which bent the mixing auxiliary tool of the syringe system shown in FIG.
  • a syringe system 10 according to the first embodiment shown in FIG. 1 is a device for mixing a filler in one barrel and a filler in the other barrel.
  • the syringe system 10 can be equipped with a syringe kit 12 including two syringes whose tip portions can be connected to each other for mixing the medicine M, and a connected syringe kit 12 in which two syringes are connected to each other.
  • FIG. 1 shows a state where the syringe kit 12 is attached to the mixing aid 14.
  • the syringe kit 12 includes a male syringe 16 and a female syringe 18 that can be screwed together. Both the male syringe 16 and the female syringe 18 are configured as prefilled syringes pre-filled with contents such as drugs.
  • the side connected to the female syringe 18 or the direction thereof is referred to as “tip portion” or “tip direction”, and the opposite side or the opposite direction is referred to as “base end portion” or “ It is called “proximal direction”.
  • the side connected to the male syringe 16 or the direction thereof is referred to as a “tip portion” or “tip direction”, and the opposite side or the opposite direction is referred to as a “base end portion” or “base end direction”.
  • the male syringe 16 is connected to the barrel 20 for a male syringe made of a hollow body, a gasket 22 slidably inserted into the barrel 20 for a male syringe, and the gasket 22.
  • a pusher 24A and a medicine M filled in a filling space 21 formed by a barrel 20 for a male syringe and a gasket 22 are provided.
  • male syringe barrel 20 is abbreviated as “male barrel 20”.
  • the male barrel 20 has a substantially cylindrical shape and a barrel body 20a having a proximal end formed at the proximal end, a nozzle 20b provided at the distal end of the barrel body 20a, and a lock provided outside the nozzle 20b. It has an adapter 20c, a flange 20f projecting radially outward from the base end of the barrel body 20a, and a finger grip 26A provided at the base end of the barrel body 20a.
  • the barrel body 20a, the nozzle 20b, the lock adapter 20c, and the flange 20f are integrally formed.
  • the barrel body 20a, the nozzle 20b, the lock adapter 20c, and the flange 20f constitute a male barrel main body.
  • the nozzle 20b is reduced in diameter with respect to the barrel barrel 20a from the center of the tip of the barrel barrel 20a and extends in the tip direction.
  • the nozzle 20b has a passage 20g (see FIG. 4) penetrating in the axial direction and communicating with the inner cavity (filling space 21) of the barrel body 20a.
  • the nozzle 20b is configured as a male luer having a circular outer cross section and a tapered outer peripheral surface 20bs whose outer diameter decreases toward the tip.
  • the nozzle 20b can be fitted to a cylinder portion 40b (mesluer), which will be described later, of the female syringe 18.
  • the lock adapter 20c is formed in a substantially hollow cylindrical shape extending from the tip of the barrel body 20a in the tip direction and concentrically surrounding the nozzle 20b.
  • a screw 20e is formed on the inner peripheral surface of the lock adapter 20c.
  • the flange portion 20f has a non-circular shape in which portions on opposite sides of a circular outer peripheral portion are cut into a straight line.
  • the gasket 22 is inserted into the barrel body 20a through a proximal end opening that opens at the proximal end of the barrel body 20a.
  • the gasket 22 seals the base end side of the barrel body 20a in a liquid-tight manner.
  • the gasket 22 is made of an elastic material such as a rubber material.
  • the outer periphery of the gasket 22 is in liquid-tight contact with the inner peripheral surface of the barrel body 20a, and is slidably disposed in the barrel body 20a.
  • a gasket 22 is connected to the tip of the pusher 24A.
  • the pusher 24A has a shaft portion 28A having a distal end portion connected to the gasket 22, and a pusher base end portion 30A provided at the base end of the shaft portion 28A.
  • the pusher base end portion 30A is formed in a flange shape projecting radially outward from the base end of the shaft portion 28A.
  • the finger grip 26A is a grip member 27A attached to the flange portion 20f so as to be rotatable around the axis of the male barrel 20.
  • the grip member 27 ⁇ / b> A has a base portion 32 attached to the proximal end portion of the male barrel 20 and a pair of finger hook portions 34 protruding in opposite directions, and the short shaft as viewed from the axial direction of the male barrel 20. It is formed in a non-circular shape having a long axis.
  • the finger grip 26 ⁇ / b> A has a U-shaped flange mounting groove 36. By inserting (fitting) the flange portion 20f into the flange mounting groove 36, the male barrel 20 and the grip member 27A are fixed so as not to be relatively movable in the axial direction.
  • a medical liquid ML specifically, a solution such as physiological saline
  • a powdered medicine a freeze-dried medicine, or the like.
  • Any solid drug, liquid drug, etc. may be used.
  • examples of such a drug M include protein preparations, peptide preparations, antitumor agents, vitamin agents (general vitamin agents), various amino acids, antithrombotic agents such as heparin, insulin, antibiotics, analgesics, cardiotonics, Note: Anesthetic agents, medical narcotics, anti-Parkinson agents, ulcer treatment agents, corticosteroid agents, arrhythmia agents and the like.
  • a cap (not shown) is attached to the nozzle 20b, and the tip opening 20b1 of the nozzle 20b is sealed by this cap. This cap is removed from the nozzle 20b when the male syringe 16 is used (when the syringe kit 12 is used).
  • the female syringe 18 has a female syringe barrel 40 made of a hollow body, a gasket 42 slidably inserted into the female syringe barrel 40, a pusher 24B connected to the gasket 42, and a female syringe barrel 40. And a medical liquid ML filled in a filling space 43 formed by the gasket 42.
  • female barrel 40 is abbreviated as “female barrel 40”.
  • the female barrel 40 has a substantially cylindrical shape and a barrel body 40a having a proximal end formed at the proximal end, a cylindrical portion 40b protruding from the distal end of the barrel body 40a in the distal direction, and a base of the barrel body 40a.
  • the flange portion 40f is formed to protrude radially outward from the end, and the finger grip 26B is attached to the proximal end portion of the barrel body portion 40a.
  • the barrel body 40a, the cylinder portion 40b, and the flange portion 40f constitute a female barrel main body.
  • the tube portion 40b extends from the tip of the barrel body 40a in the tip direction.
  • the cylinder part 40b has a passage that penetrates in the axial direction and communicates with the inner cavity (filling space 43) of the barrel body part 40a.
  • the cylindrical portion 40b is configured as a female luer having a tapered inner peripheral surface 40bs (see also FIG. 4) whose outer diameter increases in the distal direction.
  • Two protrusions 40d projecting outward (radially outward) opposite to each other with respect to the axis (center line) of the cylindrical portion 40b are provided on the outer periphery of the distal end of the cylindrical portion 40b.
  • the two protrusions 40d can be screwed with a screw 20e provided on the lock adapter 20c of the male barrel 20.
  • the flange portion 40f has a non-circular shape in which portions on opposite sides of the circular outer peripheral portion are cut in a straight line.
  • the gasket 42 is inserted into the barrel body 40a through a proximal end opening that opens at the proximal end of the barrel body 40a.
  • the gasket 42 seals the base end side of the barrel body 40a in a liquid-tight manner.
  • the gasket 42 is made of an elastic material such as a rubber material.
  • the gasket 42 is disposed so that its outer peripheral portion is in liquid-tight contact with the inner peripheral surface of the barrel barrel 40a and is slidable within the barrel barrel 40a.
  • a gasket 42 is connected to the tip of the pusher 24B.
  • the pusher 24B has a shaft portion 28B having a distal end portion connected to the gasket 42, and a pusher base end portion 30B provided at the base end of the shaft portion 28B.
  • the pusher base end portion 30B is formed in a flange shape protruding radially outward from the base end of the shaft portion 28B.
  • the finger grip 26B is a grip member 27B attached to the flange portion 40f so as to be rotatable about the axis of the knife barrel 40.
  • the grip member 27 ⁇ / b> B has a base portion 46 attached to the proximal end portion of the female barrel 40 and a pair of finger hook portions 48 protruding in opposite directions from the base portion 46, as viewed from the axial direction of the female barrel 40.
  • the non-circular shape has a short axis and a long axis.
  • the finger grip 26 ⁇ / b> A has a U-shaped flange mounting groove 50.
  • a cap (not shown) is attached to the tube portion 40b, and the tip opening of the tube portion 40b is sealed by this cap. This cap is removed from the cylindrical portion 40b when the female syringe 18 is used (when the syringe kit 12 is used).
  • the medical liquid ML is a liquid that can dissolve, dilute, or mix the drug M in the male syringe 16.
  • a medical liquid ML may be a drug solution such as physiological saline, a drug diluent, a drug mixture, or a drug solution containing a drug (for example, a vitamin or mineral).
  • the medical liquid ML is not filled in the female syringe 18 in advance as in the present embodiment, but may be aspirated in a necessary amount into the empty female syringe 18 from a vial or the like as necessary.
  • the male barrel 20 and the female barrel 40 are made of a hard material having transparency.
  • Examples of the constituent material of the male barrel 20 and the female barrel 40 include cyclic polyolefin, polypropylene, and polycarbonate.
  • air is contained in the filling space formed on the tip side of the gasket in at least one of the male syringe 16 and the female syringe 18.
  • the mixing assisting tool 14 includes a first mounting portion 54 ⁇ / b> A on which one pusher base end portion 30 ⁇ / b> A of the connected syringe kit 12 can be mounted, and a connected syringe kit.
  • the connecting portion 58 has two connecting members 60 extending to face each other.
  • 54 A of 1st mounting parts, the 2nd mounting part 54B, and the connection part 58 are integrally molded by injection molding etc., for example.
  • the pusher proximal end 30A of the male syringe 16 is attached to the first attachment portion 54A
  • the pusher proximal end 30B of the female syringe 18 is attached to the second attachment portion 54B.
  • the state is shown.
  • the pusher base end 30A of the male syringe 16 may be mounted on the second mounting portion 54B
  • the pusher base end 30B of the female syringe 18 may be mounted on the first mounting portion 54A.
  • the first mounting portion 54A and the second mounting portion 54B are opposed to each other with an interval in the longitudinal direction of the mixing aid 14. Since the first mounting portion 54A and the second mounting portion 54B are configured in the same shape, the configuration of the first mounting portion 54A will be typically described below.
  • the first mounting portion 54 ⁇ / b> A supports the proximal end surface of the pusher proximal end portion 30 ⁇ / b> A and pushes between the finger holding portion 62 pressed by the finger and the finger holding portion 62.
  • a holding portion 64 that holds the child base end portion 30A.
  • the finger contact portion 62 has a flange contact surface 62a that contacts the proximal end surface of the pusher proximal end portion 30A, and a finger contact surface 62b that is formed on the opposite side of the flange contact surface 62a and is pressed by a finger. Is provided.
  • the finger holder 62 is formed in a circular plate shape. As shown in FIG. 3, the width Wf of the finger holder 62 in the direction perpendicular to the longitudinal direction of the mixing aid 14 is larger than the diameter D (see FIG. 2) of the pusher base end 30A, and the finger grip It is smaller than the length La along the long axis of 26A.
  • the sandwiching portion 64 has a pair of engaging protrusions 64 a that protrude from the connecting portion 58 to face each other.
  • a slit 64b (gap) is formed between the pair of engaging protrusions 64a.
  • the shaft portion 28A of the pusher 24A is disposed (inserted) in the slit 64b.
  • the width of the clamping part 64 is smaller than the width Wf of the finger holding part 62.
  • the finger contact surface 62b of the finger holder 62 is provided with a locking projection 68 that can be engaged with the outer peripheral portion of the pusher base end 30A.
  • the pusher proximal end 30A is located between the finger holding portion 62 and the clamping portion 64 from the side opposite to the side where the locking projection 68 is provided. Inserted into. At that time, the position of the pusher 24 with respect to the first mounting portion 54 ⁇ / b> A is positioned at an appropriate position by the locking protrusion 68.
  • the two connecting members 60 constituting the connecting portion 58 extend in a straight line between the first mounting portion 54A and the second mounting portion 54B in parallel with each other. One end side of each of the two connecting members 60 is connected to the first mounting portion 54A. The other end side of each of the two connecting members 60 is connected to the second mounting portion 54B.
  • the syringe kit 12 is disposed between the two connecting members 60. That is, the mixing aid 14 has a rectangular frame shape by the two connecting members 60, the first mounting portion 54A, and the second mounting portion 54B, and the syringe kit 12 is arranged inside the frame shape. It is configured.
  • the width W of the connecting portion 58 in the direction perpendicular to the longitudinal direction of the mixing aid 14 is smaller than the lengths La and Lb along the long axes of the finger grips 26A and 26B. Accordingly, the finger grips 26A and 26B protrude outward from the connecting portion 58 in a state where the first and second pusher base end portions 30A and 30B are attached to the first attachment portion 54A and the second attachment portion 54B. .
  • the mixing aid 14 is made of a hard material.
  • Examples of the constituent material of the mixing aid 14 include cyclic polyolefin, polypropylene, and polycarbonate.
  • the mixing aid 14 may be made of a metal material.
  • caps are respectively removed (opened) from the nozzle 20b of the male barrel 20 and the cylindrical portion 40b of the female barrel 40.
  • the male barrel 20 and the female barrel 40 are connected to each other.
  • the screw 20e (FIG. 2) of the lock adapter 20c and the protrusion 40d (FIG. 2) provided on the cylindrical portion 40b of the female barrel 40 are screwed together.
  • the nozzle 20b (male lure) of the male barrel 20 is inserted into the cylinder part 40b (male luer) of the female barrel 40.
  • the tapered outer peripheral surface 20bs (FIG. 2) of the nozzle 20b is liquid-tightly fitted to the tapered inner peripheral surface 40bs (FIG. 2) of the cylindrical portion 40b.
  • the syringe kit 12 in a state where the male syringe 16 and the female syringe 18 are connected to each other is attached to the mixing aid 14.
  • the pusher base end portions 30A and 30B of the male syringe 16 and the female syringe 18 are inserted and attached to the first mounting portion 54A and the second mounting portion 54B, respectively.
  • the syringe kit 12 is disposed between the two connecting members 60 constituting the connecting portion 58, and the pair of finger hanging portions 34 and the pair of finger hanging portions 48 from between the two connecting members 60 are more than the connecting portion 58. It will be in the state which protrudes outside, respectively.
  • the medical liquid ML and the medicine M are mixed by performing a pumping operation using the pusher 24A of the male syringe 16 and the pusher 24B of the female syringe 18.
  • the finger holding unit 62 of the second mounting portion 54B is moved to the first position with another finger (for example, the thumb) of the same hand.
  • the pusher 24B of the female syringe 18 is pressed toward the distal end of the female syringe 18 via the second mounting portion 54B.
  • the finger mounting portion 62 of the first mounting portion 54A is secondly mounted with another finger (for example, the thumb) of the same hand.
  • the pusher 24A of the male syringe 16 is pressed toward the distal end of the male syringe 16 via the first mounting part 54A.
  • the liquid mixture a mixture of the medical liquid ML and the medicine M
  • dissolution, dilution or mixing of the drug M is promoted, and a desired drug solution is adjusted.
  • the syringe system 10 according to the first embodiment has the following effects.
  • the pushers 24 ⁇ / b> A and 24 ⁇ / b> B of the two syringes 16 and 18 are connected to each other by the mixing assisting tool 14, so when an operation of pushing one pusher in the distal direction is performed, An operation in which the child is pulled in the proximal direction occurs. Thereby, the medicine can be transferred smoothly and the mixing time can be shortened. Further, even when air is contained in the syringe, the air is not compressed during mixing, and smooth mixing is possible. Furthermore, since the mixing can be performed by pressing the pushers 24A and 24B as in the case where the mixing aid 14 is not used, the mixing can be performed with the same operation feeling as in the conventional case.
  • the connecting portion 58 has two connecting members 60 extending to face each other. One end side of each of the two connecting members 60 is connected to the first mounting portion 54A. The other end side of each of the two connecting members 60 is connected to the second mounting portion 54B. And the syringe kit 12 is arrange
  • Each of the first mounting portion 54A and the second mounting portion 54B has a finger contact portion 62 that supports the proximal end surface of the pusher proximal end portion 30A and is pressed with a finger.
  • the width W of the finger holder 62 is larger than the diameter D of the pusher base end portions 30A and 30B and smaller than the lengths La and Lb along the long axes of the finger grips 26A and 26B.
  • Finger grips 26A and 26B are grip members 27A and 27B attached to flange portions 26d and 40f so as to be rotatable about the axis of the barrel. With this configuration, the grip members 27A and 27B can be easily and reliably protruded to the outside of the connecting portion 58 regardless of the screwing state of the screwing protrusions (screws 20e and protrusions 40d).
  • the flange portions 26d and 40f of the male barrel 20 and the female barrel 40 have a non-circular shape having a major axis and a minor axis.
  • the direction of the rotation direction may be different from the flange portion 40f.
  • the grip members 27A and 27B can rotate with respect to the male barrel 20 and the female barrel 40, respectively, the syringe kit 12 is mixed with the mixing aid 14 after adjusting the direction of the rotation direction of the grip members 27A and 27B.
  • the grip members 27A and 27B can be reliably projected outward from the connecting portion 58.
  • the grip members 27 ⁇ / b> A and 27 ⁇ / b> B can be reliably put on the fingers, and the mixing operation can be performed smoothly.
  • the total length L1 of the syringe kit 12 with the male syringe 16 and the female syringe 18 connected to each other is different from the length L2 between the first mounting portion 54A and the second mounting portion 54B.
  • FIG. 6 shows a case where L1 is longer than L2, conversely, L1 may be shorter than L2.
  • air is contained in the filling space formed on the tip side of the gasket in at least one barrel of the male syringe 16 and the female syringe 18.
  • the pusher (the pusher 24A or the pusher 24B) can be moved in the axial direction to some extent by the compression or expansion of the air existing in the filling space. Therefore, the syringe kit 12 can be attached to the mixing aid 14 without forcibly deforming the connecting portion 58.
  • the mixing aid 14 a of the syringe system 10 a has a first form (FIG. 7) in which the connected syringe kit 12 can be mounted and a shorter overall length than the first form.
  • the second form (FIG. 8) can be modified. With this configuration, the mixing aid 14a can be stored in a compact form in the second form before the use of the mixing aid 14a. Further, after use, the mixing aid 14a can be deformed from the first form to the second form and discarded compactly.
  • the connecting portion 58 of the mixing aid 14a includes a first member 70 having a first mounting portion 54A and a second member 72 having a second mounting portion 54B.
  • the first member 70 and the second member 72 are connected to each other via a hinge portion 74 so as to be rotatable.
  • the mixing aid 14 a is configured to be foldable in a shape that can be folded at an intermediate portion of the connecting portion 58.
  • the second member 72 is configured to be shorter than the first member 70.
  • the first mounting part 54A and the second mounting part 54B are arranged so as to be shifted in the longitudinal direction of the mixing assisting tool 14a, and A part of the second mounting portion 54B is inserted between the connecting members 60 on the first member 70 side.
  • variety of the mixing auxiliary tool 14a in a folded state can be made smaller, and further compactification is achieved.
  • the pusher base end portions 30A and 30B may not have a flange shape.
  • the shaft portion 28A and the pusher base end portion 30A of the pusher 24A may be formed in an integral cylindrical shape (the same applies to the pusher 24B).
  • a notch portion is provided on the outer peripheral surface of each pusher base end portion 30A, 30B, and a protrusion that can be inserted into the notch portion serves as a first mounting portion 54A and a second mounting portion 54B. 14.
  • the insertion opening part is provided in the base end surface of each pusher base end part 30A, 30B, and the insertion auxiliary

Landscapes

  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

A mixing assistance tool (14) that comprises: a first mounting part (54A) at which one plunger base part (30A) of a syringe kit (12) can be mounted; a second mounting part (54B) at which another plunger base part (30B) of the syringe kit (12) can be mounted; and a rod-shaped connection part (58) that connects the first mounting part (54A) and the second mounting part (54B). The width of the connection part (58) is smaller than the major-axis length of finger clips (26A, 26B). When the one and the other plunger base parts (30A, 30B) have been mounted at the first mounting part (54A) and the second mounting part (54B), the finger clips (26A, 26B) protrude further to the outside than the connection part (58).

Description

混合補助具及びシリンジシステムMixing aid and syringe system
　本発明は、２つのシリンジ内の薬剤を混合する際に用いられる混合補助具及びシリンジシステムに関する。 The present invention relates to a mixing aid and a syringe system used when mixing medicines in two syringes.
　従来、２つのシリンジ内の薬剤を混合するための二薬混合用のシリンジキットは公知である（例えば、特開２０１３－１３２３４９号公報参照）。この種のシリンジキットの使用においては、２つのシリンジ内の薬剤を混合するために、２つのシリンジのバレル同士を接続し、一方のシリンジの押し子を押すことで、当該一方のシリンジのバレル内の薬剤を他方のシリンジのバレルに移行させる。 Conventionally, a syringe kit for mixing two drugs for mixing drugs in two syringes is known (for example, see JP2013-132349A). In the use of this type of syringe kit, in order to mix the drugs in the two syringes, the barrels of the two syringes are connected to each other, and the pusher of one syringe is pushed, so Is transferred to the barrel of the other syringe.
　従来の二薬混合用のシリンジキットでは、一方のバレルから他方のバレルへと薬剤を移行させる際、他方のバレル内のガスケットの抵抗を受けて薬剤が移行できないか、あるいは移行に時間がかかることがある。特に、シリンジ内に空気が多い粉剤の場合、空気の圧縮によるバッファが大きく、移行に時間がかかる。 In the conventional syringe kit for mixing two drugs, when transferring the drug from one barrel to the other, the drug cannot be transferred due to the resistance of the gasket in the other barrel, or the transfer takes time. There is. In particular, in the case of a powder with a lot of air in the syringe, the buffer due to the compression of air is large, and it takes time to shift.
　本発明はこのような課題を考慮してなされたものであり、シリンジキットを用いた薬剤の混合時間を短縮することが可能な混合補助具及びシリンジシステムを提供することを目的とする。 The present invention has been made in consideration of such problems, and an object thereof is to provide a mixing aid and a syringe system capable of shortening the mixing time of a medicine using a syringe kit.
　上記の目的を達成するため、本発明は、薬剤を混合するために先端部同士が互いに接続可能な２つのシリンジを備えたシリンジキットに装着可能な混合補助具であって、前記２つのシリンジの各々は、基端に径方向外側に突出したフィンガグリップを有するバレルと、バレル内に摺動可能に配置されたガスケットと、前記ガスケットに接続されるとともに基端に押し子基端部を有し前記バレルの基端開口から基端方向に突出した押し子とを備え、前記フィンガグリップは、短軸と長軸を有する非円形形状に形成され、前記混合補助具は、前記２つのシリンジが互いに接続された接続状態の前記シリンジキットの一方の前記押し子基端部が装着可能な第１装着部と、前記接続状態の前記シリンジキットの他方の前記押し子基端部が装着可能な第２装着部と、前記第１装着部と前記第２装着部とを連結する棒状の連結部と、を備え、前記連結部の、前記混合補助具の長手方向と垂直な方向の幅は、前記フィンガグリップの前記長軸に沿った長さよりも小さく、前記第１装着部と前記第２装着部に一方及び他方の前記押し子基端部がそれぞれ装着されている状態で、前記フィンガグリップが前記連結部よりも外側に突出することを特徴とする。 In order to achieve the above object, the present invention provides a mixing aid that can be attached to a syringe kit including two syringes whose tip portions can be connected to each other in order to mix a medicine, Each has a barrel having a finger grip projecting radially outward at the proximal end, a gasket slidably disposed within the barrel, and a pusher proximal end connected to the gasket and at the proximal end A pusher protruding in the proximal direction from the proximal end opening of the barrel, the finger grip is formed in a non-circular shape having a short axis and a long axis, and the two auxiliary syringes are connected to each other. A first mounting portion to which one of the pusher base end portions of the connected syringe kit in the connected state can be mounted and a second pusher base end portion of the syringe kit in the connected state can be mounted. 2 mounting portions, and a rod-shaped connecting portion that connects the first mounting portion and the second mounting portion, and the width of the connecting portion in the direction perpendicular to the longitudinal direction of the mixing aid is The finger grip is smaller than the length of the finger grip along the long axis, and the one and the other pusher base end portions are respectively attached to the first attachment portion and the second attachment portion. It protrudes outward from the connecting portion.
　上記の構成を備えた混合補助具によれば、２つのシリンジの押し子同士が混合補助具により連結されているため、一方の押し子を先端方向に押す操作を行うと、同時に他方の押し子が基端方向に引っ張られる操作が生じる。これにより、薬剤の移行がスムーズに行われ、混合時間を短縮することが可能となる。また、シリンジ内に空気が入っている場合でも、混合時に空気の圧縮が起こらず、スムーズに混合することが可能となる。さらに、混合補助具を用いない場合と同様に押し子を押すような操作で混合が行えるため、同様の操作感覚で混合を行うことが可能である。 According to the mixing aid having the above-described configuration, the pushers of the two syringes are connected to each other by the mixing aid. Therefore, when an operation of pushing one pusher in the distal direction is performed, the other pusher is simultaneously performed. The operation of pulling in the proximal direction occurs. Thereby, the medicine can be transferred smoothly and the mixing time can be shortened. Further, even when air is contained in the syringe, the air is not compressed during mixing, and smooth mixing is possible. Furthermore, since the mixing can be performed by pressing the pusher as in the case where the mixing aid is not used, the mixing can be performed with the same operation feeling.
　連結部は、互いに対向して延在する２つの連結部材を有し、前記２つの連結部材の各々の一端側は、前記第１装着部に連結されており、前記２つの連結部材の各々の他端側は、前記第２装着部に連結されており、前記接続状態の前記シリンジキットが前記混合補助具に装着された状態で、前記シリンジキットは、前記２つの連結部材の間に配置されてもよい。 The connecting portion includes two connecting members extending opposite to each other, and one end side of each of the two connecting members is connected to the first mounting portion, and each of the two connecting members The other end side is connected to the second mounting portion, and the syringe kit is disposed between the two connecting members in a state where the connected syringe kit is mounted on the mixing aid. May be.
　この構成により、混合操作時の連結部の変形が抑制されるため、薬剤の移行を一層スムーズに行うことができる。 This configuration suppresses deformation of the connecting portion during the mixing operation, so that the drug can be transferred more smoothly.
　前記第１装着部及び前記第２装着部は、前記押し子基端部の基端面を支持するとともに指で押圧される指当部を有し、前記指当部の、前記混合補助具の長手方向と垂直な方向の幅は、前記押し子基端部の直径よりも大きく、且つ前記フィンガグリップの前記長軸に沿った長さよりも小さくてもよい。 The first mounting part and the second mounting part include a finger support part that supports the base end surface of the pusher base end part and is pressed with a finger, and the length of the mixing assisting tool of the finger support part The width in the direction perpendicular to the direction may be larger than the diameter of the pusher base end and smaller than the length of the finger grip along the major axis.
　この構成により、指当部が適度な大きさを有するため、混合操作を行う際に、指当部に指を当てて押し子を押しやすい。 With this configuration, since the finger holder has an appropriate size, it is easy to press the pusher by placing a finger on the finger holder when performing a mixing operation.
　前記混合補助具は、接続状態の前記シリンジキットを装着可能な第１形態と、前記第１形態よりも全長が短くなった第２形態とに変形可能であってもよい。 The mixing aid may be deformable into a first form in which the syringe kit in a connected state can be mounted and a second form having a shorter overall length than the first form.
　この構成により、混合補助具の使用前には第２形態にしてコンパクトに保管しておくことができる。また、使用後には第１形態から第２形態に変形させてコンパクトに廃棄することができる。 This configuration allows the second form to be stored compactly before using the mixing aid. Moreover, after use, it can be changed into a 2nd form from a 1st form, and can be discarded compactly.
　前記連結部は、前記第１装着部を有する第１部材と、前記第２装着部を有する第２部材とを有し、前記第１部材と前記第２部材とはヒンジ部を介して互いに回動可能に連結されていてもよい。 The connecting portion includes a first member having the first mounting portion and a second member having the second mounting portion, and the first member and the second member rotate with each other via a hinge portion. It may be movably connected.
　これにより、簡易且つ経済的な構成で、第１形態と第２形態とに変形可能な混合補助具を実現することができる。 Thereby, it is possible to realize a mixing aid that can be transformed into the first form and the second form with a simple and economical configuration.
　また、本発明は、薬剤を混合するために先端部同士が互いに接続可能な２つのシリンジを備えたシリンジキットと、前記２つのシリンジが互いに接続された接続状態の前記シリンジキットが装着可能な混合補助具と、を備えたシリンジシステムであって、前記２つのシリンジの各々は、基端にフィンガグリップを有するバレルと、バレル内に摺動可能に配置されたガスケットと、前記ガスケットに接続されるとともに基端に押し子基端部を有し前記バレルの基端開口から基端方向に突出した押し子とを備え、前記フィンガグリップは、短軸と長軸を有する非円形形状に形成され、前記混合補助具は、前記接続状態の前記シリンジキットの一方の前記押し子基端部が装着可能な第１装着部と、前記接続状態の前記シリンジキットの他方の前記押し子基端部が装着可能な第２装着部と、前記第１装着部と前記第２装着部とを連結する棒状の連結部と、を備え、前記連結部の、前記混合補助具の長手方向と垂直な方向の幅は、前記押し子基端部の前記長軸に沿った長さよりも小さく、前記第１装着部と前記第２装着部に一方及び他方の前記押し子基端部が装着されている状態で、前記フィンガグリップが前記連結部よりも外側に突出することを特徴とする。 Further, the present invention provides a syringe kit including two syringes whose tip portions can be connected to each other in order to mix a drug and a syringe kit in which the two syringes are connected to each other. Each of the two syringes is connected to the gasket, a barrel having a finger grip at a proximal end, a gasket slidably disposed in the barrel, and a syringe system. And a pusher having a pusher proximal end at the proximal end and projecting in the proximal direction from the proximal opening of the barrel, the finger grip is formed in a non-circular shape having a short axis and a long axis, The mixing assisting tool includes a first mounting portion on which one of the pusher base end portions of the syringe kit in the connected state can be mounted, and the other of the syringe kit in the connected state. A second attachment portion to which a lever base end portion can be attached; and a rod-like connection portion that connects the first attachment portion and the second attachment portion; and the length of the mixing aid of the connection portion The width in the direction perpendicular to the direction is smaller than the length of the pusher base end portion along the major axis, and one and the other pusher base end portions are provided on the first mounting portion and the second mounting portion. The finger grip protrudes outward from the connecting portion in a mounted state.
　上記シリンジシステムにおいて、連結部は、互いに対向して延在する２つの連結部材を有し、前記２つの連結部材の各々の一端側は、前記第１装着部に連結されており、前記２つの連結部材の各々の他端側は、前記第２装着部に連結されており、前記接続状態の前記シリンジキットが前記混合補助具に装着された状態で、前記シリンジキットは、前記２つの連結部材の間に配置されてもよい。 In the syringe system, the connecting portion includes two connecting members extending opposite to each other, and one end side of each of the two connecting members is connected to the first mounting portion, and the two The other end side of each connecting member is connected to the second mounting part, and the syringe kit is connected to the two connecting members in a state where the connected syringe kit is mounted to the mixing aid. It may be arranged between.
　この構成により、混合操作時の連結部の変形が抑制されるため、薬剤の移行を一層スムーズに行うことができる。 This configuration suppresses deformation of the connecting portion during the mixing operation, so that the drug can be transferred more smoothly.
　上記シリンジシステムにおいて、前記第１装着部及び前記第２装着部は、前記押し子基端部の基端面を支持するとともに指で押圧される指当部を有し、前記指当部の、前記混合補助具の長手方向と垂直な方向の幅は、前記押し子基端部の直径よりも大きく、且つ前記フィンガグリップの前記長軸に沿った長さよりも小さくてもよい。 In the syringe system, the first mounting portion and the second mounting portion include a finger support portion that supports a base end surface of the pusher base end portion and is pressed with a finger, and the finger support portion includes: The width in the direction perpendicular to the longitudinal direction of the mixing aid may be larger than the diameter of the pusher base end portion and smaller than the length of the finger grip along the major axis.
　この構成により、指当部が適度な大きさを有するため、混合操作を行う際に、指当部に指を当てて押し子を押しやすい。 With this configuration, since the finger holder has an appropriate size, it is easy to press the pusher by placing a finger on the finger holder when performing a mixing operation.
　上記シリンジシステムにおいて、前記混合補助具は、接続状態の前記シリンジキットを装着可能な第１形態と、前記第１形態よりも全長が短くなった第２形態とに変形可能であってもよい。 In the syringe system, the mixing aid may be deformable into a first form in which the connected syringe kit can be mounted and a second form in which the overall length is shorter than that in the first form.
　この構成により、混合補助具の使用前には第２形態にしてコンパクトに保管しておくことができる。また、使用後には第１形態から第２形態に変形させてコンパクトに廃棄することができる。 This configuration allows the second form to be stored compactly before using the mixing aid. Moreover, after use, it can be changed into a 2nd form from a 1st form, and can be discarded compactly.
　上記シリンジシステムにおいて、前記連結部は、前記第１装着部を有する第１部材と、前記第２装着部を有する第２部材とを有し、前記第１部材と前記第２部材とはヒンジ部を介して互いに回動可能に連結されていてもよい。 In the syringe system, the connecting portion includes a first member having the first mounting portion and a second member having the second mounting portion, and the first member and the second member are hinge portions. It may be connected so that rotation is possible mutually.
　これにより、簡易且つ経済的な構成で、第１形態と第２形態とに変形可能な混合補助具を実現することができる。 Thereby, it is possible to realize a mixing aid that can be transformed into the first form and the second form with a simple and economical configuration.
　上記シリンジシステムにおいて、前記シリンジキットの初期状態で、前記２つのシリンジの少なくとも一方の前記バレル内の前記ガスケットよりも先端側に形成された充填空間には空気が入っていてもよい。 In the syringe system, in the initial state of the syringe kit, air may be contained in the filling space formed on the tip side of the gasket in the barrel of at least one of the two syringes.
　この構成により、２つのシリンジが互いに接続された状態のシリンジキットの全長と、第１装着部と第２装着部との間の長さとが異なる場合でも、空気の分だけ押し子を軸方向に移動させることができるため、連結部を無理に変形させることなくシリンジキットを混合補助具に装着することが可能である。 With this configuration, even when the total length of the syringe kit in a state where the two syringes are connected to each other and the length between the first mounting portion and the second mounting portion are different, the pusher is moved in the axial direction by the amount of air. Since it can be moved, it is possible to attach the syringe kit to the mixing aid without forcibly deforming the connecting portion.
　上記シリンジシステムにおいて、前記２つのシリンジの前記バレルの先端部には、互いに螺合可能な螺合用突起部が設けられており、前記バレルの基端には、径方向外側に突出したフランジ部が設けられ、前記フィンガグリップは、前記バレルの軸を中心に回転可能に前記フランジ部に装着されたグリップ部材であってもよい。 In the syringe system described above, a tip of the barrel of the two syringes is provided with a screwing projection that can be screwed together, and a flange that protrudes radially outward is provided at the base end of the barrel. The finger grip provided may be a grip member attached to the flange portion so as to be rotatable about an axis of the barrel.
　この構成により、螺合用突起部の螺合状態によらずに、連結部の外側にフィンガグリップを容易且つ確実に突出させることができる。 With this configuration, the finger grip can be easily and reliably protruded outside the connecting portion regardless of the screwing state of the screwing protrusion.
　本発明の混合補助具及びシリンジシステムによれば、シリンジキットを用いた薬剤の混合時間を短縮することが可能となる。 According to the mixing aid and syringe system of the present invention, it is possible to shorten the mixing time of the medicine using the syringe kit.
本発明の第１実施形態に係るシリンジシステムの斜視図である。1 is a perspective view of a syringe system according to a first embodiment of the present invention. シリンジキット（接続前）の斜視図である。It is a perspective view of a syringe kit (before connection). 図１に示したシリンジシステムの平面図である。It is a top view of the syringe system shown in FIG. 図３におけるＩＶ－ＩＶ線に沿った断面図である。FIG. 4 is a sectional view taken along line IV-IV in FIG. 3. シリンジキット（接続後）の斜視図である。It is a perspective view of a syringe kit (after connection). シリンジキットと混合補助具の長さが異なる場合の説明図である。It is explanatory drawing when the length of a syringe kit and a mixing aid differs. 本発明の第２実施形態に係るシリンジシステムの斜視図である。It is a perspective view of the syringe system which concerns on 2nd Embodiment of this invention. 図７に示したシリンジシステムの混合補助具を折り曲げた状態の斜視図である。It is a perspective view of the state which bent the mixing auxiliary tool of the syringe system shown in FIG.
　以下、本発明に係る混合補助具及びシリンジシステムについて好適な実施形態を挙げ、添付の図面を参照しながら説明する。なお、第２実施形態において、第１実施形態と同一又は同様な要素には同一の参照符号を付し、詳細な説明を省略する。 Hereinafter, preferred embodiments of the mixing aid and the syringe system according to the present invention will be described with reference to the accompanying drawings. In the second embodiment, the same or similar elements as those in the first embodiment are denoted by the same reference numerals, and detailed description thereof is omitted.
［第１実施形態］
　図１に示す第１実施形態に係るシリンジシステム１０は、一方のバレル内の充填物と他方のバレル内の充填物とを混合するためのデバイスである。このシリンジシステム１０は、薬剤Ｍを混合するために先端部同士が互いに接続可能な２つのシリンジを備えたシリンジキット１２と、２つのシリンジが互いに接続された接続状態のシリンジキット１２が装着可能な混合補助具１４とを備える。図１では、シリンジキット１２が混合補助具１４に装着された状態を示している。 [First Embodiment]
A syringe system 10 according to the first embodiment shown in FIG. 1 is a device for mixing a filler in one barrel and a filler in the other barrel. The syringe system 10 can be equipped with a syringe kit 12 including two syringes whose tip portions can be connected to each other for mixing the medicine M, and a connected syringe kit 12 in which two syringes are connected to each other. A mixing aid 14. FIG. 1 shows a state where the syringe kit 12 is attached to the mixing aid 14.
　シリンジキット１２は、互いに螺合接続可能なオスシリンジ１６とメスシリンジ１８とを備える。オスシリンジ１６とメスシリンジ１８は、ともに薬剤等の内容物が予め充填されたプレフィルドシリンジとして構成されている。 The syringe kit 12 includes a male syringe 16 and a female syringe 18 that can be screwed together. Both the male syringe 16 and the female syringe 18 are configured as prefilled syringes pre-filled with contents such as drugs.
　なお、以下の説明では、オスシリンジ１６について、メスシリンジ１８と接続される側あるいはその方向を「先端部」あるいは「先端方向」と呼び、その逆側あるいは逆方向を「基端部」あるいは「基端方向」と呼ぶ。また、メスシリンジ１８について、オスシリンジ１６と接続される側あるいはその方向を「先端部」あるいは「先端方向」と呼び、その逆側あるいは逆方向を「基端部」あるいは「基端方向」と呼ぶ。 In the following description, for the male syringe 16, the side connected to the female syringe 18 or the direction thereof is referred to as “tip portion” or “tip direction”, and the opposite side or the opposite direction is referred to as “base end portion” or “ It is called “proximal direction”. Further, for the female syringe 18, the side connected to the male syringe 16 or the direction thereof is referred to as a “tip portion” or “tip direction”, and the opposite side or the opposite direction is referred to as a “base end portion” or “base end direction”. Call.
　図２及び図４に示すように、オスシリンジ１６は、中空体からなるオスシリンジ用バレル２０と、オスシリンジ用バレル２０内に摺動可能に挿入されたガスケット２２と、ガスケット２２に連結された押し子２４Ａと、オスシリンジ用バレル２０とガスケット２２とにより形成される充填空間２１に充填された薬剤Ｍとを備える。以下、「オスシリンジ用バレル２０」を「オスバレル２０」と略称する。 As shown in FIGS. 2 and 4, the male syringe 16 is connected to the barrel 20 for a male syringe made of a hollow body, a gasket 22 slidably inserted into the barrel 20 for a male syringe, and the gasket 22. A pusher 24A and a medicine M filled in a filling space 21 formed by a barrel 20 for a male syringe and a gasket 22 are provided. Hereinafter, “male syringe barrel 20” is abbreviated as “male barrel 20”.
　オスバレル２０は、略円筒形状をなすとともに基端に基端開口部が形成されたバレル胴部２０ａと、バレル胴部２０ａの先端に設けられたノズル２０ｂと、ノズル２０ｂの外側に設けられたロックアダプタ２０ｃと、バレル胴部２０ａの基端から径方向外側に突出したフランジ部２０ｆと、バレル胴部２０ａの基端部に設けられたフィンガグリップ２６Ａとを有する。バレル胴部２０ａ、ノズル２０ｂ、ロックアダプタ２０ｃ及びフランジ部２０ｆは一体成形されている。バレル胴部２０ａ、ノズル２０ｂ、ロックアダプタ２０ｃ及びフランジ部２０ｆにより、オスバレル本体が構成されている。 The male barrel 20 has a substantially cylindrical shape and a barrel body 20a having a proximal end formed at the proximal end, a nozzle 20b provided at the distal end of the barrel body 20a, and a lock provided outside the nozzle 20b. It has an adapter 20c, a flange 20f projecting radially outward from the base end of the barrel body 20a, and a finger grip 26A provided at the base end of the barrel body 20a. The barrel body 20a, the nozzle 20b, the lock adapter 20c, and the flange 20f are integrally formed. The barrel body 20a, the nozzle 20b, the lock adapter 20c, and the flange 20f constitute a male barrel main body.
　ノズル２０ｂは、バレル胴部２０ａの先端中心部からバレル胴部２０ａに対して縮径して先端方向に延出している。ノズル２０ｂは、軸方向に貫通するとともにバレル胴部２０ａの内腔（充填空間２１）と連通した通路２０ｇ（図４参照）を有する。 The nozzle 20b is reduced in diameter with respect to the barrel barrel 20a from the center of the tip of the barrel barrel 20a and extends in the tip direction. The nozzle 20b has a passage 20g (see FIG. 4) penetrating in the axial direction and communicating with the inner cavity (filling space 21) of the barrel body 20a.
　ノズル２０ｂは、横断面外形が円形状であって、先端方向に向かって外径が減少するテーパ状外周面２０ｂｓを有するオスルアーとして構成されている。ノズル２０ｂは、メスシリンジ１８の後述する筒部４０ｂ（メスルアー）に嵌合可能である。 The nozzle 20b is configured as a male luer having a circular outer cross section and a tapered outer peripheral surface 20bs whose outer diameter decreases toward the tip. The nozzle 20b can be fitted to a cylinder portion 40b (mesluer), which will be described later, of the female syringe 18.
　図２に示すように、ロックアダプタ２０ｃは、バレル胴部２０ａの先端から先端方向に延出し且つノズル２０ｂを同心状に囲む略中空円筒状に構成されている。ロックアダプタ２０ｃの内周面にはネジ２０ｅが形成されている。 As shown in FIG. 2, the lock adapter 20c is formed in a substantially hollow cylindrical shape extending from the tip of the barrel body 20a in the tip direction and concentrically surrounding the nozzle 20b. A screw 20e is formed on the inner peripheral surface of the lock adapter 20c.
　フランジ部２０ｆは、円形の外周部の互いに反対側の部分を直線状にカットした非円形形状を有する。 The flange portion 20f has a non-circular shape in which portions on opposite sides of a circular outer peripheral portion are cut into a straight line.
　ガスケット２２は、バレル胴部２０ａの基端で開口する基端開口部を介してバレル胴部２０ａ内に挿入されている。ガスケット２２によってバレル胴部２０ａの基端側が液密に封止されている。ガスケット２２は、例えばゴム材等の弾性材料により構成されている。ガスケット２２は、その外周部がバレル胴部２０ａの内周面に液密に接するとともに、バレル胴部２０ａ内に摺動可能に配置されている。 The gasket 22 is inserted into the barrel body 20a through a proximal end opening that opens at the proximal end of the barrel body 20a. The gasket 22 seals the base end side of the barrel body 20a in a liquid-tight manner. The gasket 22 is made of an elastic material such as a rubber material. The outer periphery of the gasket 22 is in liquid-tight contact with the inner peripheral surface of the barrel body 20a, and is slidably disposed in the barrel body 20a.
　押し子２４Ａの先端部に、ガスケット２２が連結されている。具体的に、押し子２４Ａは、先端部がガスケット２２に連結された軸部２８Ａと、軸部２８Ａの基端に設けられた押し子基端部３０Ａとを有する。押し子基端部３０Ａは、軸部２８Ａの基端から径方向外方に突出したフランジ状に形成されている。ユーザが押し子２４Ａを軸方向（先端方向又は基端方向）に押圧することにより、ガスケット２２がバレル胴部２０ａ内を軸方向に摺動する。なお、押し子２４Ａは、オスシリンジ１６を使用する際に、ガスケット２２に連結されてもよい。 A gasket 22 is connected to the tip of the pusher 24A. Specifically, the pusher 24A has a shaft portion 28A having a distal end portion connected to the gasket 22, and a pusher base end portion 30A provided at the base end of the shaft portion 28A. The pusher base end portion 30A is formed in a flange shape projecting radially outward from the base end of the shaft portion 28A. When the user presses the pusher 24A in the axial direction (the distal end direction or the proximal end direction), the gasket 22 slides in the barrel body 20a in the axial direction. The pusher 24 </ b> A may be coupled to the gasket 22 when using the male syringe 16.
　フィンガグリップ２６Ａは、オスバレル２０の軸を中心に回転可能にフランジ部２０ｆに装着されたグリップ部材２７Ａである。グリップ部材２７Ａは、オスバレル２０の基端部に装着されるベース部３２と、互いに反対方向に突出した一対の指掛け部３４とを有しており、オスバレル２０の軸方向から見て、短軸と長軸を有する非円形形状に形成されている。フィンガグリップ２６Ａは、Ｕ字状のフランジ装着溝３６を有する。当該フランジ装着溝３６にフランジ部２０ｆが挿入（嵌合）されることで、オスバレル２０とグリップ部材２７Ａとが軸方向に相対移動不可能に固定されている。 The finger grip 26A is a grip member 27A attached to the flange portion 20f so as to be rotatable around the axis of the male barrel 20. The grip member 27 </ b> A has a base portion 32 attached to the proximal end portion of the male barrel 20 and a pair of finger hook portions 34 protruding in opposite directions, and the short shaft as viewed from the axial direction of the male barrel 20. It is formed in a non-circular shape having a long axis. The finger grip 26 </ b> A has a U-shaped flange mounting groove 36. By inserting (fitting) the flange portion 20f into the flange mounting groove 36, the male barrel 20 and the grip member 27A are fixed so as not to be relatively movable in the axial direction.
　薬剤Ｍは、メスシリンジ１８内に充填された医療用液体ＭＬ（具体的には、生理食塩水等の溶解液）によって溶解・希釈・混合されるものであれば、粉末状薬剤、凍結乾燥薬剤、固形状薬剤、液状薬剤等、どのようなものであってもよい。このような薬剤Ｍとしては、例えば、タンパク製剤、ペプチド製剤、抗腫瘍剤、ビタミン剤（総合ビタミン剤）、各種アミノ酸、ヘパリンのような抗血栓剤、インシュリン、抗生物質、鎮痛剤、強心剤、静注麻酔剤、医療用麻薬、抗パーキンソン剤、潰瘍治療剤、副腎皮質ホルモン剤、不整脈用剤等が挙げられる。 As long as the medicine M is dissolved / diluted / mixed by a medical liquid ML (specifically, a solution such as physiological saline) filled in the female syringe 18, it is a powdered medicine, a freeze-dried medicine, or the like. Any solid drug, liquid drug, etc. may be used. Examples of such a drug M include protein preparations, peptide preparations, antitumor agents, vitamin agents (general vitamin agents), various amino acids, antithrombotic agents such as heparin, insulin, antibiotics, analgesics, cardiotonics, Note: Anesthetic agents, medical narcotics, anti-Parkinson agents, ulcer treatment agents, corticosteroid agents, arrhythmia agents and the like.
　なお、オスシリンジ１６の初期状態で、ノズル２０ｂには図示しないキャップが装着されており、このキャップによってノズル２０ｂの先端開口部２０ｂ１が封止されている。このキャップは、オスシリンジ１６の使用時（シリンジキット１２の使用時）にノズル２０ｂから取り外される。 In the initial state of the male syringe 16, a cap (not shown) is attached to the nozzle 20b, and the tip opening 20b1 of the nozzle 20b is sealed by this cap. This cap is removed from the nozzle 20b when the male syringe 16 is used (when the syringe kit 12 is used).
　メスシリンジ１８は、中空体からなるメスシリンジ用バレル４０と、メスシリンジ用バレル４０内に摺動可能に挿入されたガスケット４２と、ガスケット４２に連結された押し子２４Ｂと、メスシリンジ用バレル４０とガスケット４２とにより形成される充填空間４３に充填された医療用液体ＭＬとを備える。以下、「メスシリンジ用バレル４０」を「メスバレル４０」と略称する。 The female syringe 18 has a female syringe barrel 40 made of a hollow body, a gasket 42 slidably inserted into the female syringe barrel 40, a pusher 24B connected to the gasket 42, and a female syringe barrel 40. And a medical liquid ML filled in a filling space 43 formed by the gasket 42. Hereinafter, “barrel 40 for female syringe” is abbreviated as “female barrel 40”.
　メスバレル４０は、略円筒形状をなすとともに基端に基端開口部が形成されたバレル胴部４０ａと、バレル胴部４０ａの先端から先端方向に突出した筒部４０ｂと、バレル胴部４０ａの基端から径方向外側に突出形成されたフランジ部４０ｆと、バレル胴部４０ａの基端部に装着されたフィンガグリップ２６Ｂとを有する。バレル胴部４０ａ、筒部４０ｂ及びフランジ部４０ｆにより、メスバレル本体が構成されている。 The female barrel 40 has a substantially cylindrical shape and a barrel body 40a having a proximal end formed at the proximal end, a cylindrical portion 40b protruding from the distal end of the barrel body 40a in the distal direction, and a base of the barrel body 40a. The flange portion 40f is formed to protrude radially outward from the end, and the finger grip 26B is attached to the proximal end portion of the barrel body portion 40a. The barrel body 40a, the cylinder portion 40b, and the flange portion 40f constitute a female barrel main body.
　筒部４０ｂは、バレル胴部４０ａの先端から先端方向に延出している。筒部４０ｂは、軸方向に貫通するとともにバレル胴部４０ａの内腔（充填空間４３）と連通した通路を有する。筒部４０ｂは、先端方向に向かって外径が増大するテーパ状内周面４０ｂｓ（図４も参照）を有するメスルアーとして構成されている。 The tube portion 40b extends from the tip of the barrel body 40a in the tip direction. The cylinder part 40b has a passage that penetrates in the axial direction and communicates with the inner cavity (filling space 43) of the barrel body part 40a. The cylindrical portion 40b is configured as a female luer having a tapered inner peripheral surface 40bs (see also FIG. 4) whose outer diameter increases in the distal direction.
　筒部４０ｂの先端外周部には、筒部４０ｂの軸線（中心線）を基準に互いに反対の外方（径方向外方）に突出した２つの突起４０ｄが設けられている。２つの突起４０ｄは、オスバレル２０のロックアダプタ２０ｃに設けられたネジ２０ｅと螺合可能である。 Two protrusions 40d projecting outward (radially outward) opposite to each other with respect to the axis (center line) of the cylindrical portion 40b are provided on the outer periphery of the distal end of the cylindrical portion 40b. The two protrusions 40d can be screwed with a screw 20e provided on the lock adapter 20c of the male barrel 20.
　フランジ部４０ｆは、円形の外周部の互いに反対側の部分を直線状にカットした非円形形状を有する。 The flange portion 40f has a non-circular shape in which portions on opposite sides of the circular outer peripheral portion are cut in a straight line.
　図２において、ガスケット４２は、バレル胴部４０ａの基端で開口する基端開口部を介してバレル胴部４０ａ内に挿入されている。ガスケット４２によってバレル胴部４０ａの基端側が液密に封止されている。ガスケット４２は、例えばゴム材等の弾性材料により構成されている。ガスケット４２は、その外周部がバレル胴部４０ａの内周面に液密に接するとともに、バレル胴部４０ａ内に摺動可能に配置されている。 In FIG. 2, the gasket 42 is inserted into the barrel body 40a through a proximal end opening that opens at the proximal end of the barrel body 40a. The gasket 42 seals the base end side of the barrel body 40a in a liquid-tight manner. The gasket 42 is made of an elastic material such as a rubber material. The gasket 42 is disposed so that its outer peripheral portion is in liquid-tight contact with the inner peripheral surface of the barrel barrel 40a and is slidable within the barrel barrel 40a.
　押し子２４Ｂの先端部に、ガスケット４２が連結されている。具体的に、押し子２４Ｂは、先端部がガスケット４２に連結された軸部２８Ｂと、軸部２８Ｂの基端に設けられた押し子基端部３０Ｂとを有する。押し子基端部３０Ｂは、軸部２８Ｂの基端から径方向外方に突出したフランジ状に形成されている。ユーザが押し子２４Ｂを軸方向（先端方向又は基端方向）に押圧することにより、ガスケット４２がバレル胴部４０ａ内を軸方向に摺動する。なお、押し子２４Ｂは、メスシリンジ１８を使用する際に、ガスケット４２に連結されてもよい。 A gasket 42 is connected to the tip of the pusher 24B. Specifically, the pusher 24B has a shaft portion 28B having a distal end portion connected to the gasket 42, and a pusher base end portion 30B provided at the base end of the shaft portion 28B. The pusher base end portion 30B is formed in a flange shape protruding radially outward from the base end of the shaft portion 28B. When the user presses the pusher 24B in the axial direction (the front end direction or the base end direction), the gasket 42 slides in the barrel body 40a in the axial direction. The pusher 24 </ b> B may be coupled to the gasket 42 when using the female syringe 18.
　フィンガグリップ２６Ｂは、メスバレル４０の軸を中心に回転可能にフランジ部４０ｆに装着されたグリップ部材２７Ｂである。グリップ部材２７Ｂは、メスバレル４０の基端部に装着されるベース部４６と、ベース部４６から互いに反対方向に突出した一対の指掛け部４８とを有しており、メスバレル４０の軸方向から見て、短軸と長軸を有する非円形形状に形成されている。フィンガグリップ２６Ａは、Ｕ字状のフランジ装着溝５０を有する。当該フランジ装着溝５０にフランジ部４０ｆが挿入（嵌合）されることで、メスバレル４０とグリップ部材２７Ｂとが軸方向に相対移動不可能に固定されている。 The finger grip 26B is a grip member 27B attached to the flange portion 40f so as to be rotatable about the axis of the knife barrel 40. The grip member 27 </ b> B has a base portion 46 attached to the proximal end portion of the female barrel 40 and a pair of finger hook portions 48 protruding in opposite directions from the base portion 46, as viewed from the axial direction of the female barrel 40. The non-circular shape has a short axis and a long axis. The finger grip 26 </ b> A has a U-shaped flange mounting groove 50. By inserting (fitting) the flange portion 40f into the flange mounting groove 50, the knife barrel 40 and the grip member 27B are fixed so as not to be relatively movable in the axial direction.
　メスシリンジ１８の初期状態で、筒部４０ｂには図示しないキャップが装着されており、このキャップによって筒部４０ｂの先端開口部が封止されている。このキャップは、メスシリンジ１８の使用時（シリンジキット１２の使用時）に筒部４０ｂから取り外される。 In the initial state of the female syringe 18, a cap (not shown) is attached to the tube portion 40b, and the tip opening of the tube portion 40b is sealed by this cap. This cap is removed from the cylindrical portion 40b when the female syringe 18 is used (when the syringe kit 12 is used).
　医療用液体ＭＬは、オスシリンジ１６内の薬剤Ｍの溶解、希釈又は混合が可能な液体である。このような医療用液体ＭＬとしては、生理食塩水等の薬剤溶解液、薬剤希釈液、薬剤混合液、あるいは薬剤（例えば、ビタミン剤、ミネラル類）を含有する薬液でもあってもよい。なお、医療用液体ＭＬは、本実施形態のように予めメスシリンジ１８に充填されたものでなく、バイアル等から必要に応じて空のメスシリンジ１８内に必要量吸引されたものでもよい。 The medical liquid ML is a liquid that can dissolve, dilute, or mix the drug M in the male syringe 16. Such a medical liquid ML may be a drug solution such as physiological saline, a drug diluent, a drug mixture, or a drug solution containing a drug (for example, a vitamin or mineral). The medical liquid ML is not filled in the female syringe 18 in advance as in the present embodiment, but may be aspirated in a necessary amount into the empty female syringe 18 from a vial or the like as necessary.
　オスバレル２０及びメスバレル４０は、透明性を有する硬質材料により構成されている。オスバレル２０及びメスバレル４０の構成材料としては、例えば、環状ポリオレフィン、ポリプロピレン、ポリカーボネート等が挙げられる。 The male barrel 20 and the female barrel 40 are made of a hard material having transparency. Examples of the constituent material of the male barrel 20 and the female barrel 40 include cyclic polyolefin, polypropylene, and polycarbonate.
　シリンジキット１２の初期状態において、オスシリンジ１６及びメスシリンジ１８のうち少なくとも一方のバレル内のガスケットよりも先端側に形成された充填空間には空気が入っている。 In the initial state of the syringe kit 12, air is contained in the filling space formed on the tip side of the gasket in at least one of the male syringe 16 and the female syringe 18.
　図１、図３及び図４に示すように、混合補助具１４は、接続状態のシリンジキット１２の一方の押し子基端部３０Ａが装着可能な第１装着部５４Ａと、接続状態のシリンジキット１２の他方の押し子基端部３０Ｂが装着可能な第２装着部５４Ｂと、第１装着部５４Ａと第２装着部５４Ｂとを連結する棒状の連結部５８とを備える。連結部５８は、互いに対向して延在する２つの連結部材６０を有する。第１装着部５４Ａと、第２装着部５４Ｂと、連結部５８とは、例えば射出成形等により一体成形されている。 As shown in FIGS. 1, 3, and 4, the mixing assisting tool 14 includes a first mounting portion 54 </ b> A on which one pusher base end portion 30 </ b> A of the connected syringe kit 12 can be mounted, and a connected syringe kit. A second attachment portion 54B to which the other 12 pusher base end portions 30B can be attached, and a rod-like connection portion 58 that connects the first attachment portion 54A and the second attachment portion 54B. The connecting portion 58 has two connecting members 60 extending to face each other. 54 A of 1st mounting parts, the 2nd mounting part 54B, and the connection part 58 are integrally molded by injection molding etc., for example.
　図１、図３及び図４では、オスシリンジ１６の押し子基端部３０Ａが第１装着部５４Ａに装着され、メスシリンジ１８の押し子基端部３０Ｂが第２装着部５４Ｂに装着された状態が示されている。なお、オスシリンジ１６の押し子基端部３０Ａが第２装着部５４Ｂに装着され、メスシリンジ１８の押し子基端部３０Ｂが第１装着部５４Ａに装着されてもよい。 In FIGS. 1, 3 and 4, the pusher proximal end 30A of the male syringe 16 is attached to the first attachment portion 54A, and the pusher proximal end 30B of the female syringe 18 is attached to the second attachment portion 54B. The state is shown. The pusher base end 30A of the male syringe 16 may be mounted on the second mounting portion 54B, and the pusher base end 30B of the female syringe 18 may be mounted on the first mounting portion 54A.
　第１装着部５４Ａ及び第２装着部５４Ｂは、混合補助具１４の長手方向に間隔を置いて互いに対向している。第１装着部５４Ａ及び第２装着部５４Ｂは、同一形状に構成されているため、以下では代表的に第１装着部５４Ａの構成について説明する。 The first mounting portion 54A and the second mounting portion 54B are opposed to each other with an interval in the longitudinal direction of the mixing aid 14. Since the first mounting portion 54A and the second mounting portion 54B are configured in the same shape, the configuration of the first mounting portion 54A will be typically described below.
　図１及び図４に示すように、第１装着部５４Ａは、押し子基端部３０Ａの基端面を支持するとともに指で押圧される指当部６２と、指当部６２との間で押し子基端部３０Ａを挟持する挟持部６４とを有する。指当部６２には、押し子基端部３０Ａの基端面に当接するフランジ当接面６２ａと、フランジ当接面６２ａとは反対側に形成されるとともに指で押圧される指当面６２ｂとが設けられている。 As shown in FIGS. 1 and 4, the first mounting portion 54 </ b> A supports the proximal end surface of the pusher proximal end portion 30 </ b> A and pushes between the finger holding portion 62 pressed by the finger and the finger holding portion 62. And a holding portion 64 that holds the child base end portion 30A. The finger contact portion 62 has a flange contact surface 62a that contacts the proximal end surface of the pusher proximal end portion 30A, and a finger contact surface 62b that is formed on the opposite side of the flange contact surface 62a and is pressed by a finger. Is provided.
　第１実施形態において、指当部６２は円形板状に形成されている。図３に示すように、指当部６２の、混合補助具１４の長手方向と垂直な方向の幅Ｗｆは、押し子基端部３０Ａの直径Ｄ（図２参照）よりも大きく、且つフィンガグリップ２６Ａの長軸に沿った長さＬａよりも小さい。 In the first embodiment, the finger holder 62 is formed in a circular plate shape. As shown in FIG. 3, the width Wf of the finger holder 62 in the direction perpendicular to the longitudinal direction of the mixing aid 14 is larger than the diameter D (see FIG. 2) of the pusher base end 30A, and the finger grip It is smaller than the length La along the long axis of 26A.
　図１及び図４に示すように、挟持部６４は、連結部５８から互いに対向して突出した一対の係合突起６４ａを有する。一対の係合突起６４ａ間にはスリット６４ｂ（隙間）が形成されている。シリンジキット１２が混合補助具１４に装着された状態では、当該スリット６４ｂに押し子２４Ａの軸部２８Ａが配置（挿入）されている。挟持部６４の幅は、指当部６２の幅Ｗｆよりも小さい。 As shown in FIGS. 1 and 4, the sandwiching portion 64 has a pair of engaging protrusions 64 a that protrude from the connecting portion 58 to face each other. A slit 64b (gap) is formed between the pair of engaging protrusions 64a. In a state where the syringe kit 12 is mounted on the mixing aid 14, the shaft portion 28A of the pusher 24A is disposed (inserted) in the slit 64b. The width of the clamping part 64 is smaller than the width Wf of the finger holding part 62.
　図１及び図３に示すように、指当部６２の指当面６２ｂには、押し子基端部３０Ａの外周部に係合可能な係止突起６８が設けられている。第１装着部５４Ａに押し子２４のフランジを装着する際には、係止突起６８が設けられた側とは反対側から押し子基端部３０Ａが指当部６２と挟持部６４との間に挿入される。その際、係止突起６８により、第１装着部５４Ａに対する押し子２４の位置が適正位置に位置決めされる。 As shown in FIGS. 1 and 3, the finger contact surface 62b of the finger holder 62 is provided with a locking projection 68 that can be engaged with the outer peripheral portion of the pusher base end 30A. When the flange of the pusher 24 is attached to the first attachment portion 54A, the pusher proximal end 30A is located between the finger holding portion 62 and the clamping portion 64 from the side opposite to the side where the locking projection 68 is provided. Inserted into. At that time, the position of the pusher 24 with respect to the first mounting portion 54 </ b> A is positioned at an appropriate position by the locking protrusion 68.
　連結部５８を構成する２つの連結部材６０は、第１装着部５４Ａと第２装着部５４Ｂとの間を互いに平行に且つ直線状に延在している。２つの連結部材６０の各々の一端側は、第１装着部５４Ａに連結されている。２つの連結部材６０の各々の他端側は、第２装着部５４Ｂに連結されている。 The two connecting members 60 constituting the connecting portion 58 extend in a straight line between the first mounting portion 54A and the second mounting portion 54B in parallel with each other. One end side of each of the two connecting members 60 is connected to the first mounting portion 54A. The other end side of each of the two connecting members 60 is connected to the second mounting portion 54B.
　接続状態のシリンジキット１２が混合補助具１４に装着された状態では、シリンジキット１２は、２つの連結部材６０の間に配置される。すなわち、混合補助具１４は、２つの連結部材６０、第１装着部５４Ａ及び第２装着部５４Ｂにより、長方形の枠形状の形態を有し、枠形状の内側にシリンジキット１２が配置されように構成されている。 In a state where the connected syringe kit 12 is mounted on the mixing aid 14, the syringe kit 12 is disposed between the two connecting members 60. That is, the mixing aid 14 has a rectangular frame shape by the two connecting members 60, the first mounting portion 54A, and the second mounting portion 54B, and the syringe kit 12 is arranged inside the frame shape. It is configured.
　図３に示すように、連結部５８の、混合補助具１４の長手方向と垂直な方向の幅Ｗは、フィンガグリップ２６Ａ、２６Ｂの長軸に沿った長さＬａ、Ｌｂよりも小さい。これにより、第１装着部５４Ａと第２装着部５４Ｂに一方及び他方の押し子基端部３０Ａ、３０Ｂが装着されている状態で、フィンガグリップ２６Ａ、２６Ｂが連結部５８よりも外側に突出する。 As shown in FIG. 3, the width W of the connecting portion 58 in the direction perpendicular to the longitudinal direction of the mixing aid 14 is smaller than the lengths La and Lb along the long axes of the finger grips 26A and 26B. Accordingly, the finger grips 26A and 26B protrude outward from the connecting portion 58 in a state where the first and second pusher base end portions 30A and 30B are attached to the first attachment portion 54A and the second attachment portion 54B. .
　混合補助具１４は、硬質材料により構成されている。混合補助具１４の構成材料としては、例えば、環状ポリオレフィン、ポリプロピレン、ポリカーボネート等が挙げられる。混合補助具１４は、金属材料により構成されてもよい。 The mixing aid 14 is made of a hard material. Examples of the constituent material of the mixing aid 14 include cyclic polyolefin, polypropylene, and polycarbonate. The mixing aid 14 may be made of a metal material.
　次に、上記のように構成されたシリンジシステム１０の使用方法について説明する。 Next, a method for using the syringe system 10 configured as described above will be described.
　まず、図２に示すオスシリンジ１６及びメスシリンジ１８において、オスバレル２０のノズル２０ｂとメスバレル４０の筒部４０ｂからそれぞれ図示しないキャップを取り外す（開栓する）。 First, in the male syringe 16 and the female syringe 18 shown in FIG. 2, caps (not shown) are respectively removed (opened) from the nozzle 20b of the male barrel 20 and the cylindrical portion 40b of the female barrel 40.
　次に、図５のように、オスバレル２０とメスバレル４０とを互いに接続する。具体的には、ロックアダプタ２０ｃのネジ２０ｅ（図２）とメスバレル４０の筒部４０ｂに設けられた突起４０ｄ（図２）とを螺合させる。この螺合に伴い、オスバレル２０のノズル２０ｂ（オスルアー）がメスバレル４０の筒部４０ｂ（メスルアー）に挿入される。これにより、ノズル２０ｂのテーパ状外周面２０ｂｓ（図２）が、筒部４０ｂのテーパ状内周面４０ｂｓ（図２）に液密に嵌合する。 Next, as shown in FIG. 5, the male barrel 20 and the female barrel 40 are connected to each other. Specifically, the screw 20e (FIG. 2) of the lock adapter 20c and the protrusion 40d (FIG. 2) provided on the cylindrical portion 40b of the female barrel 40 are screwed together. With this screwing, the nozzle 20b (male lure) of the male barrel 20 is inserted into the cylinder part 40b (male luer) of the female barrel 40. Accordingly, the tapered outer peripheral surface 20bs (FIG. 2) of the nozzle 20b is liquid-tightly fitted to the tapered inner peripheral surface 40bs (FIG. 2) of the cylindrical portion 40b.
　次に、図１のように、オスシリンジ１６とメスシリンジ１８とを互いに接続した状態のシリンジキット１２を、混合補助具１４に装着する。具体的には、オスシリンジ１６及びメスシリンジ１８の押し子基端部３０Ａ、３０Ｂを、それぞれ第１装着部５４Ａ及び第２装着部５４Ｂに挿入し、装着する。これにより、連結部５８を構成する２つの連結部材６０の間にシリンジキット１２が配置されるとともに、２つの連結部材６０間から一対の指掛け部３４及び一対の指掛け部４８が連結部５８よりも外側にそれぞれ突出する状態となる。 Next, as shown in FIG. 1, the syringe kit 12 in a state where the male syringe 16 and the female syringe 18 are connected to each other is attached to the mixing aid 14. Specifically, the pusher base end portions 30A and 30B of the male syringe 16 and the female syringe 18 are inserted and attached to the first mounting portion 54A and the second mounting portion 54B, respectively. Accordingly, the syringe kit 12 is disposed between the two connecting members 60 constituting the connecting portion 58, and the pair of finger hanging portions 34 and the pair of finger hanging portions 48 from between the two connecting members 60 are more than the connecting portion 58. It will be in the state which protrudes outside, respectively.
　次に、オスシリンジ１６の押し子２４Ａとメスシリンジ１８の押し子２４Ｂとを用いて、ポンピング操作を行うことにより、医療用液体ＭＬと薬剤Ｍとを混合する。 Next, the medical liquid ML and the medicine M are mixed by performing a pumping operation using the pusher 24A of the male syringe 16 and the pusher 24B of the female syringe 18.
　具体的には、メスシリンジ１８のグリップ部材２７Ｂに指（例えば、人差し指及び中指）を掛けながら、それと同じ手の他の指（例えば、親指）で第２装着部５４Ｂの指当部６２を第１装着部５４Ａ側に向かって押すことにより、第２装着部５４Ｂを介して、メスシリンジ１８の押し子２４Ｂをメスシリンジ１８の先端方向に押圧する。これにより、メスバレル４０内からオスバレル２０内へと医療用液体ＭＬを注入し、オスバレル２０内で医療用液体ＭＬと薬剤Ｍとを混合する。 Specifically, while holding a finger (for example, an index finger and a middle finger) on the grip member 27B of the female syringe 18, the finger holding unit 62 of the second mounting portion 54B is moved to the first position with another finger (for example, the thumb) of the same hand. By pushing toward the first mounting portion 54A side, the pusher 24B of the female syringe 18 is pressed toward the distal end of the female syringe 18 via the second mounting portion 54B. Thereby, the medical liquid ML is injected from the female barrel 40 into the male barrel 20, and the medical liquid ML and the medicine M are mixed in the male barrel 20.
　第２装着部５４Ｂを押圧する際、押圧に基づく移動力（操作力）は、連結部５８を介して第１装着部５４Ａへと伝達される。このため、第２装着部５４Ｂを押圧するのと同時に、第１装着部５４Ａに装着されたオスシリンジ１６の押し子２４Ａが引っ張られる作用が生じる。 When the second mounting portion 54B is pressed, the movement force (operation force) based on the pressing is transmitted to the first mounting portion 54A via the connecting portion 58. For this reason, the action of pulling the pusher 24A of the male syringe 16 attached to the first attachment portion 54A occurs simultaneously with pressing the second attachment portion 54B.
　次に、オスシリンジ１６のグリップ部材２７Ａに指（例えば、人差し指及び中指）を掛けながら、それと同じ手の他の指（例えば、親指）で第１装着部５４Ａの指当部６２を第２装着部５４Ｂ側に向かって押すことにより、第１装着部５４Ａを介して、オスシリンジ１６の押し子２４Ａをオスシリンジ１６の先端方向に押圧する。これにより、オスバレル２０内からメスバレル４０内へと混合液（医療用液体ＭＬと薬剤Ｍとが混ざったもの）を注入する。そして、オスバレル２０とメスバレル４０との間でこのような混合液の移動を何度か繰り返し行うことにより、薬剤Ｍの溶解、希釈又は混合が促進され、所望の薬液が調整される。 Next, while putting a finger (for example, an index finger and a middle finger) on the grip member 27A of the male syringe 16, the finger mounting portion 62 of the first mounting portion 54A is secondly mounted with another finger (for example, the thumb) of the same hand. By pushing toward the part 54B side, the pusher 24A of the male syringe 16 is pressed toward the distal end of the male syringe 16 via the first mounting part 54A. Thereby, the liquid mixture (a mixture of the medical liquid ML and the medicine M) is injected from the male barrel 20 into the female barrel 40. Then, by repeatedly moving such a mixed solution between the male barrel 20 and the female barrel 40 several times, dissolution, dilution or mixing of the drug M is promoted, and a desired drug solution is adjusted.
　第１装着部５４Ａを押圧する際、押圧に基づく移動力（操作力）は、連結部５８を介して第２装着部５４Ｂへと伝達される。このため、第１装着部５４Ａを押圧するのと同時に、第２装着部５４Ｂに装着されたメスシリンジ１８の押し子２４が引っ張られる作用が生じる。 When pressing the first mounting portion 54A, the moving force (operation force) based on the pressing is transmitted to the second mounting portion 54B via the connecting portion 58. For this reason, the action of pulling the pusher 24 of the female syringe 18 attached to the second attachment portion 54B occurs simultaneously with pressing the first attachment portion 54A.
　この場合、第１実施形態に係るシリンジシステム１０は、以下の効果を奏する。 In this case, the syringe system 10 according to the first embodiment has the following effects.
　シリンジシステム１０によれば、２つのシリンジ１６、１８の押し子２４Ａ、２４Ｂ同士が混合補助具１４により連結されているため、一方の押し子を先端方向に押す操作を行うと、同時に他方の押し子が基端方向に引っ張られる操作が生じる。これにより、薬剤の移行がスムーズに行われ、混合時間を短縮することが可能となる。また、シリンジ内に空気が入っている場合でも、混合時に空気の圧縮が起こらず、スムーズに混合することが可能となる。さらに、混合補助具１４を用いない場合と同様に押し子２４Ａ、２４Ｂを押すような操作で混合が行えるため、従来と同様の操作感覚で混合を行うことが可能である。 According to the syringe system 10, the pushers 24 </ b> A and 24 </ b> B of the two syringes 16 and 18 are connected to each other by the mixing assisting tool 14, so when an operation of pushing one pusher in the distal direction is performed, An operation in which the child is pulled in the proximal direction occurs. Thereby, the medicine can be transferred smoothly and the mixing time can be shortened. Further, even when air is contained in the syringe, the air is not compressed during mixing, and smooth mixing is possible. Furthermore, since the mixing can be performed by pressing the pushers 24A and 24B as in the case where the mixing aid 14 is not used, the mixing can be performed with the same operation feeling as in the conventional case.
　連結部５８は、互いに対向して延在する２つの連結部材６０を有する。２つの連結部材６０の各々の一端側は、第１装着部５４Ａに連結されている。２つの連結部材６０の各々の他端側は、第２装着部５４Ｂに連結されている。そして、接続状態のシリンジキット１２が混合補助具１４に装着された状態で、シリンジキット１２は、２つの連結部材６０の間に配置される。この構成により、混合操作時の連結部５８の変形が抑制されるため、薬剤の移行を一層スムーズに行うことができる。 The connecting portion 58 has two connecting members 60 extending to face each other. One end side of each of the two connecting members 60 is connected to the first mounting portion 54A. The other end side of each of the two connecting members 60 is connected to the second mounting portion 54B. And the syringe kit 12 is arrange | positioned between the two connection members 60 in the state with which the syringe kit 12 of the connection state was mounted | worn with the mixing assistance tool 14. FIG. With this configuration, since the deformation of the connecting portion 58 during the mixing operation is suppressed, the medicine can be transferred more smoothly.
　第１装着部５４Ａ及び第２装着部５４Ｂの各々は、押し子基端部３０Ａの基端面を支持するとともに指で押圧される指当部６２を有する。指当部６２の幅Ｗは、押し子基端部３０Ａ、３０Ｂの直径Ｄよりも大きく、且つフィンガグリップ２６Ａ、２６Ｂの長軸に沿った長さＬａ、Ｌｂよりも小さい。この構成により、指当部６２が適度な大きさを有するため、混合操作を行う際に、指当部６２に指を当てて押し子２４を押しやすい。 Each of the first mounting portion 54A and the second mounting portion 54B has a finger contact portion 62 that supports the proximal end surface of the pusher proximal end portion 30A and is pressed with a finger. The width W of the finger holder 62 is larger than the diameter D of the pusher base end portions 30A and 30B and smaller than the lengths La and Lb along the long axes of the finger grips 26A and 26B. With this configuration, since the finger holder 62 has an appropriate size, it is easy to press the pusher 24 by placing a finger on the finger holder 62 when performing a mixing operation.
　フィンガグリップ２６Ａ、２６Ｂは、バレルの軸を中心に回転可能にフランジ部２６ｄ、４０ｆに装着されたグリップ部材２７Ａ、２７Ｂである。この構成により、螺合用突起部（ネジ２０ｅ及び突起４０ｄ）の螺合状態によらずに、連結部５８の外側にグリップ部材２７Ａ、２７Ｂを容易且つ確実に突出させることができる。 Finger grips 26A and 26B are grip members 27A and 27B attached to flange portions 26d and 40f so as to be rotatable about the axis of the barrel. With this configuration, the grip members 27A and 27B can be easily and reliably protruded to the outside of the connecting portion 58 regardless of the screwing state of the screwing protrusions (screws 20e and protrusions 40d).
　すなわち、オスバレル２０及びメスバレル４０のフランジ部２６ｄ、４０ｆは長軸と短軸を有する非円形形状であり、ネジ２０ｅ及び突起４０ｄの螺合完了状態で、オスバレル２０のフランジ部２６ｄと、メスバレル４０のフランジ部４０ｆとは、回転方向の向きが異なる場合がある。そのような場合でも、グリップ部材２７Ａ、２７Ｂはオスバレル２０及びメスバレル４０に対してそれぞれ回転可能であるため、グリップ部材２７Ａ、２７Ｂの回転方向の向きを調整してからシリンジキット１２を混合補助具１４に装着することで、連結部５８よりも外側にグリップ部材２７Ａ、２７Ｂを確実に突出させることができる。これにより、グリップ部材２７Ａ、２７Ｂに確実に指を掛けることができ、混合操作をスムーズに遂行することができる。 That is, the flange portions 26d and 40f of the male barrel 20 and the female barrel 40 have a non-circular shape having a major axis and a minor axis. The direction of the rotation direction may be different from the flange portion 40f. Even in such a case, since the grip members 27A and 27B can rotate with respect to the male barrel 20 and the female barrel 40, respectively, the syringe kit 12 is mixed with the mixing aid 14 after adjusting the direction of the rotation direction of the grip members 27A and 27B. By attaching to the grip member 27, the grip members 27A and 27B can be reliably projected outward from the connecting portion 58. As a result, the grip members 27 </ b> A and 27 </ b> B can be reliably put on the fingers, and the mixing operation can be performed smoothly.
　図６に示すように、オスシリンジ１６及びメスシリンジ１８が互いに接続された状態のシリンジキット１２の全長Ｌ１と、第１装着部５４Ａと第２装着部５４Ｂとの間の長さＬ２とが異なる場合がある。図６では、Ｌ１がＬ２よりも長い場合を示しているが、逆に、Ｌ１がＬ２よりも短い場合もあり得る。一方、シリンジキット１２の初期状態で、オスシリンジ１６及びメスシリンジ１８の少なくとも一方のバレル内のガスケットよりも先端側に形成された充填空間には空気が入っている。このため、上記Ｌ１とＬ２とが異なる場合でも、充填空間に存在する空気の圧縮もしくは膨張により、ある程度、押し子（押し子２４Ａ又は押し子２４Ｂ）を軸方向に移動させることができる。従って、連結部５８を無理に変形させることなくシリンジキット１２を混合補助具１４に装着することが可能である。 As shown in FIG. 6, the total length L1 of the syringe kit 12 with the male syringe 16 and the female syringe 18 connected to each other is different from the length L2 between the first mounting portion 54A and the second mounting portion 54B. There is a case. Although FIG. 6 shows a case where L1 is longer than L2, conversely, L1 may be shorter than L2. On the other hand, in the initial state of the syringe kit 12, air is contained in the filling space formed on the tip side of the gasket in at least one barrel of the male syringe 16 and the female syringe 18. For this reason, even when L1 and L2 are different from each other, the pusher (the pusher 24A or the pusher 24B) can be moved in the axial direction to some extent by the compression or expansion of the air existing in the filling space. Therefore, the syringe kit 12 can be attached to the mixing aid 14 without forcibly deforming the connecting portion 58.
［第２実施形態］
　図７及び図８に示す第２実施形態に係るシリンジシステム１０ａの混合補助具１４ａは、接続状態のシリンジキット１２を装着可能な第１形態（図７）と、第１形態よりも全長が短くなった第２形態（図８）とに変形可能である。この構成により、混合補助具１４のａ使用前には混合補助具１４ａを第２形態にしてコンパクトに保管しておくことができる。また、使用後には混合補助具１４ａを第１形態から第２形態に変形させてコンパクトに廃棄することができる。 [Second Embodiment]
7 and 8, the mixing aid 14 a of the syringe system 10 a according to the second embodiment has a first form (FIG. 7) in which the connected syringe kit 12 can be mounted and a shorter overall length than the first form. The second form (FIG. 8) can be modified. With this configuration, the mixing aid 14a can be stored in a compact form in the second form before the use of the mixing aid 14a. Further, after use, the mixing aid 14a can be deformed from the first form to the second form and discarded compactly.
　混合補助具１４ａの連結部５８は、第１装着部５４Ａを有する第１部材７０と、第２装着部５４Ｂを有する第２部材７２とを有する。第１部材７０と第２部材７２とはヒンジ部７４を介して互いに回動可能に連結されている。これにより、簡易且つ経済的な構成で、第１形態と第２形態とに変形可能な混合補助具１４ａを実現することができる。 The connecting portion 58 of the mixing aid 14a includes a first member 70 having a first mounting portion 54A and a second member 72 having a second mounting portion 54B. The first member 70 and the second member 72 are connected to each other via a hinge portion 74 so as to be rotatable. Thereby, the mixing aid 14a which can be transformed into the first form and the second form with a simple and economical configuration can be realized.
　具体的に、第１部材７０の第１装着部５４Ａが設けられた側とは反対側の端部７０ａと、第２部材７２の第２装着部５４Ｂが設けられた側とは反対側の端部７２ａとが、混合補助具１４の長手方向の軸に対して垂直な軸ａを中心に回動可能に連結されている。これにより、図８に示すように、混合補助具１４ａは、連結部５８の中間部で折れる形状で折り畳み可能に構成されている。 Specifically, the end 70a of the first member 70 opposite to the side where the first mounting portion 54A is provided, and the end of the second member 72 opposite to the side where the second mounting portion 54B is provided. The part 72a is coupled to be rotatable about an axis a perpendicular to the longitudinal axis of the mixing aid 14. Thereby, as shown in FIG. 8, the mixing aid 14 a is configured to be foldable in a shape that can be folded at an intermediate portion of the connecting portion 58.
　第２実施形態において、第２部材７２は、第１部材７０よりも短く構成されている。これにより、図８に示すように、混合補助具１４ａが折り畳まれた状態では、第１装着部５４Ａと第２装着部５４Ｂとが、混合補助具１４ａの長手方向にずれて配置されるとともに、第２装着部５４Ｂの一部が、第１部材７０側の連結部材６０間に挿入される。このため、折り畳み状態での混合補助具１４ａの幅をより小さくすることができ、一層のコンパクト化が図られる。 In the second embodiment, the second member 72 is configured to be shorter than the first member 70. Thereby, as shown in FIG. 8, in the state where the mixing assisting tool 14a is folded, the first mounting part 54A and the second mounting part 54B are arranged so as to be shifted in the longitudinal direction of the mixing assisting tool 14a, and A part of the second mounting portion 54B is inserted between the connecting members 60 on the first member 70 side. For this reason, the width | variety of the mixing auxiliary tool 14a in a folded state can be made smaller, and further compactification is achieved.
　なお、第２実施形態のうち、第１実施形態と共通する部分については、第１実施形態と同一又は同様の作用及び効果が得られる。 In addition, about the part which is common in 1st Embodiment among 2nd Embodiment, the same or similar operation | movement and effect as 1st Embodiment are acquired.
　上述した実施形態において、押し子基端部３０Ａ、３０Ｂは、フランジ形状でなくてもよい。例えば、押し子２４Ａの軸部２８Ａと押し子基端部３０Ａとを一体の円筒状に形成してもよい（押し子２４Ｂについても同様である）。この場合、例えば、各押し子基端部３０Ａ、３０Ｂの外周面に切欠部が設けられるとともに、当該切欠部に挿入可能な突出部が第１装着部５４Ａ及び第２装着部５４Ｂとして混合補助具１４に設けられる。もしくは、各押し子基端部３０Ａ、３０Ｂの基端面に挿入開口部が設けられ、当該挿入開口部に挿入可能な挿入突出部が第１装着部５４Ａ及び第２装着部５４Ｂとして混合補助具１４に設けられる。 In the above-described embodiment, the pusher base end portions 30A and 30B may not have a flange shape. For example, the shaft portion 28A and the pusher base end portion 30A of the pusher 24A may be formed in an integral cylindrical shape (the same applies to the pusher 24B). In this case, for example, a notch portion is provided on the outer peripheral surface of each pusher base end portion 30A, 30B, and a protrusion that can be inserted into the notch portion serves as a first mounting portion 54A and a second mounting portion 54B. 14. Or the insertion opening part is provided in the base end surface of each pusher base end part 30A, 30B, and the insertion auxiliary | assistant part which can be inserted in the said insertion opening part is the mixing auxiliary tool 14 as the 1st mounting part 54A and the 2nd mounting part 54B. Provided.
　本発明は上述した実施形態に限定されるものではなく、本発明の要旨を逸脱しない範囲において、種々の改変が可能である。 The present invention is not limited to the above-described embodiment, and various modifications can be made without departing from the gist of the present invention.

Claims (12)

  1. 　薬剤を混合するために先端部同士が互いに接続可能な２つのシリンジ（１６、１８）を備えたシリンジキット（１２）に装着可能な混合補助具（１４、１４ａ）であって、
    　前記２つのシリンジ（１６、１８）の各々は、基端に径方向外側に突出したフィンガグリップ（２６Ａ、２６Ｂ）を有するバレル（２０、４０）と、バレル（２０、４０）内に摺動可能に配置されたガスケット（２２、４２）と、前記ガスケット（２２、４２）に接続されるとともに基端に押し子基端部（３０Ａ、３０Ｂ）を有し前記バレル（２０、４０）の基端開口から基端方向に突出した押し子（２４Ａ、２４Ｂ）とを備え、前記フィンガグリップ（２６Ａ、２６Ｂ）は、短軸と長軸を有する非円形形状に形成され、
    　前記混合補助具（１４、１４ａ）は、
    　前記２つのシリンジ（１６、１８）が互いに接続された接続状態の前記シリンジキット（１２）の一方の前記押し子基端部（３０Ａ）が装着可能な第１装着部（５４Ａ）と、
    　前記接続状態の前記シリンジキット（１２）の他方の前記押し子基端部（３０Ｂ）が装着可能な第２装着部（５４Ｂ）と、
    　前記第１装着部（５４Ａ）と前記第２装着部（５４Ｂ）とを連結する棒状の連結部（５８）と、を備え、
    　前記連結部（５８）の、前記混合補助具（１４、１４ａ）の長手方向と垂直な方向の幅（Ｗ）は、前記フィンガグリップ（２６Ａ、２６Ｂ）の前記長軸に沿った長さ（Ｌａ、Ｌｂ）よりも小さく、
    　前記第１装着部（５４Ａ）と前記第２装着部（５４Ｂ）に一方及び他方の前記押し子基端部（３０Ａ、３０Ｂ）がそれぞれ装着されている状態で、前記フィンガグリップ（２６Ａ、２６Ｂ）が前記連結部（５８）よりも外側に突出する、
    　ことを特徴とする混合補助具（１４、１４ａ）。     A mixing aid (14, 14a) that can be attached to a syringe kit (12) having two syringes (16, 18) that can be connected to each other in order to mix medicines,
    Each of the two syringes (16, 18) has a barrel (20, 40) having a finger grip (26A, 26B) projecting radially outward at a proximal end, and is slidable within the barrel (20, 40). And a base end of the barrel (20, 40) which is connected to the gasket (22, 42) and has a pusher base end (30A, 30B) at the base end. The finger grips (26A, 26B) are formed in a non-circular shape having a short axis and a long axis, and pushers (24A, 24B) protruding in the proximal direction from the opening.
    The mixing aid (14, 14a)
    A first attachment portion (54A) to which one of the pusher base end portions (30A) of the syringe kit (12) in a connected state in which the two syringes (16, 18) are connected to each other can be attached;
    A second attachment part (54B) to which the other pusher base end part (30B) of the syringe kit (12) in the connected state can be attached;
    A rod-shaped connecting portion (58) for connecting the first mounting portion (54A) and the second mounting portion (54B);
    The width (W) of the connecting portion (58) in the direction perpendicular to the longitudinal direction of the mixing aid (14, 14a) is the length (La) along the long axis of the finger grip (26A, 26B). , Lb),
    The finger grips (26A, 26B) in a state where one and the other pusher base end portions (30A, 30B) are respectively attached to the first mounting portion (54A) and the second mounting portion (54B). Protrudes outward from the connecting portion (58),
    A mixing aid (14, 14a) characterized in that.
  2. 　請求項１記載の混合補助具（１４、１４ａ）において、
    　連結部（５８）は、互いに対向して延在する２つの連結部材（６０）を有し、
    　前記２つの連結部材（６０）の各々の一端側は、前記第１装着部（５４Ａ）に連結されており、
    　前記２つの連結部材（６０）の各々の他端側は、前記第２装着部（５４Ｂ）に連結されており、
    　前記接続状態の前記シリンジキット（１２）が前記混合補助具（１４、１４ａ）に装着された状態で、前記シリンジキット（１２）は、前記２つの連結部材（６０）の間に配置される、
    　ことを特徴とする混合補助具（１４、１４ａ）。     The mixing aid (14, 14a) according to claim 1,
    The connecting portion (58) has two connecting members (60) extending opposite to each other,
    One end side of each of the two connecting members (60) is connected to the first mounting portion (54A),
    The other end of each of the two connecting members (60) is connected to the second mounting portion (54B),
    The syringe kit (12) is disposed between the two connecting members (60) in a state where the connected syringe kit (12) is attached to the mixing aid (14, 14a).
    A mixing aid (14, 14a) characterized in that.
  3. 　請求項１又は２記載の混合補助具（１４、１４ａ）において、
    　前記第１装着部（５４Ａ）及び前記第２装着部（５４Ｂ）は、前記押し子基端部（３０Ａ、３０Ｂ）の基端面を支持するとともに指で押圧される指当部（６２）を有し、
    　前記指当部（６２）の、前記混合補助具（１４、１４ａ）の長手方向と垂直な方向の幅は、前記押し子基端部（３０Ａ、３０Ｂ）の直径（Ｄ）よりも大きく、且つ前記フィンガグリップ（２６Ａ、２６Ｂ）の前記長軸に沿った長さ（Ｌａ、Ｌｂ）よりも小さい、
    　ことを特徴とする混合補助具（１４、１４ａ）。     The mixing aid (14, 14a) according to claim 1 or 2,
    The first mounting part (54A) and the second mounting part (54B) have a finger contact part (62) that supports the base end face of the pusher base end part (30A, 30B) and is pressed by a finger. And
    The width of the finger holder (62) in the direction perpendicular to the longitudinal direction of the mixing aid (14, 14a) is larger than the diameter (D) of the pusher base end (30A, 30B), and Smaller than the length (La, Lb) along the major axis of the finger grip (26A, 26B),
    A mixing aid (14, 14a) characterized in that.
  4. 　請求項１～３のいずれか１項に記載の混合補助具（１４、１４ａ）において、
    　前記混合補助具（１４、１４ａ）は、接続状態の前記シリンジキット（１２）を装着可能な第１形態と、前記第１形態よりも全長が短くなった第２形態とに変形可能である、
    　ことを特徴とする混合補助具（１４、１４ａ）。     The mixing aid (14, 14a) according to any one of claims 1 to 3,
    The mixing aid (14, 14a) can be transformed into a first form in which the syringe kit (12) in a connected state can be mounted and a second form having a shorter overall length than the first form.
    A mixing aid (14, 14a) characterized in that.
  5. 　請求項４記載の混合補助具（１４ａ）において、
    　前記連結部（５８）は、前記第１装着部（５４Ａ）を有する第１部材（７０）と、前記第２装着部（５４Ｂ）を有する第２部材（７２）とを有し、前記第１部材（７０）と前記第２部材（７２）とはヒンジ部（７４）を介して互いに回動可能に連結されている、
    　ことを特徴とする混合補助具（１４ａ）。     The mixing aid (14a) according to claim 4,
    The connecting portion (58) includes a first member (70) having the first mounting portion (54A) and a second member (72) having the second mounting portion (54B). The member (70) and the second member (72) are rotatably connected to each other via a hinge portion (74).
    A mixing aid (14a) characterized in that.
  6. 　薬剤を混合するために先端部同士が互いに接続可能な２つのシリンジ（１６、１８）を備えたシリンジキット（１２）と、
    　前記２つのシリンジ（１６、１８）が互いに接続された接続状態の前記シリンジキット（１２）が装着可能な混合補助具（１４、１４ａ）と、
    　を備えたシリンジシステム（１０、１０ａ）であって、
    　前記２つのシリンジ（１６、１８）の各々は、基端にフィンガグリップ（２６Ａ、２６Ｂ）を有するバレル（２０、４０）と、バレル（２０、４０）内に摺動可能に配置されたガスケット（２２、４２）と、前記ガスケット（２２、４２）に接続されるとともに基端に押し子基端部（３０Ａ、３０Ｂ）を有し前記バレル（２０、４０）の基端開口から基端方向に突出した押し子（２４Ａ、２４Ｂ）とを備え、前記フィンガグリップ（２６Ａ、２６Ｂ）は、短軸と長軸を有する非円形形状に形成され、
    　前記混合補助具（１４、１４ａ）は、
    　前記接続状態の前記シリンジキット（１２）の一方の前記押し子基端部（３０Ａ）が装着可能な第１装着部（５４Ａ）と、
    　前記接続状態の前記シリンジキット（１２）の他方の前記押し子基端部（３０Ｂ）が装着可能な第２装着部（５４Ｂ）と、
    　前記第１装着部（５４Ａ）と前記第２装着部（５４Ｂ）とを連結する棒状の連結部（５８）と、を備え、
    　前記連結部（５８）の、前記混合補助具（１４、１４ａ）の長手方向と垂直な方向の幅（Ｗ）は、前記押し子基端部（３０Ａ、３０Ｂ）の前記長軸に沿った長さ（Ｌａ、Ｌｂ）よりも小さく、
    　前記第１装着部（５４Ａ）と前記第２装着部（５４Ｂ）に一方及び他方の前記押し子基端部（３０Ａ、３０Ｂ）が装着されている状態で、前記フィンガグリップ（２６Ａ、２６Ｂ）が前記連結部（５８）よりも外側に突出する、
    　ことを特徴とするシリンジシステム（１０、１０ａ）。     A syringe kit (12) provided with two syringes (16, 18) whose tips can be connected to each other in order to mix the medicine;
    A mixing aid (14, 14a) to which the syringe kit (12) in a connected state in which the two syringes (16, 18) are connected to each other can be mounted;
    A syringe system (10, 10a) comprising:
    Each of the two syringes (16, 18) includes a barrel (20, 40) having a finger grip (26A, 26B) at a proximal end, and a gasket (slidably disposed in the barrel (20, 40)). 22 and 42), and is connected to the gasket (22 and 42) and has a pusher base end portion (30A and 30B) at the base end in the base end direction from the base end opening of the barrel (20 and 40). The finger grips (26A, 26B) are formed in a non-circular shape having a short axis and a long axis, and a protruding pusher (24A, 24B).
    The mixing aid (14, 14a)
    A first attachment portion (54A) to which one of the pusher base end portions (30A) of the syringe kit (12) in the connected state can be attached;
    A second attachment part (54B) to which the other pusher base end part (30B) of the syringe kit (12) in the connected state can be attached;
    A rod-shaped connecting portion (58) for connecting the first mounting portion (54A) and the second mounting portion (54B);
    The width (W) of the connecting portion (58) in the direction perpendicular to the longitudinal direction of the mixing aid (14, 14a) is the length along the major axis of the pusher base end portion (30A, 30B). Smaller than (La, Lb),
    The finger grips (26A, 26B) are in a state where one and the other pusher base end portions (30A, 30B) are mounted on the first mounting portion (54A) and the second mounting portion (54B). Projecting outward from the connecting portion (58),
    A syringe system (10, 10a) characterized in that.
  7. 　請求項６記載のシリンジシステム（１０、１０ａ）において、
    　連結部（５８）は、互いに対向して延在する２つの連結部材（６０）を有し、
    　前記２つの連結部材（６０）の各々の一端側は、前記第１装着部（５４Ａ）に連結されており、
    　前記２つの連結部材（６０）の各々の他端側は、前記第２装着部（５４Ｂ）に連結されており、
    　前記接続状態の前記シリンジキット（１２）が前記混合補助具（１４、１４ａ）に装着された状態で、前記シリンジキット（１２）は、前記２つの連結部材（６０）の間に配置される、
    　ことを特徴とするシリンジシステム（１０、１０ａ）。     Syringe system (10, 10a) according to claim 6,
    The connecting portion (58) has two connecting members (60) extending opposite to each other,
    One end side of each of the two connecting members (60) is connected to the first mounting portion (54A),
    The other end of each of the two connecting members (60) is connected to the second mounting portion (54B),
    The syringe kit (12) is disposed between the two connecting members (60) in a state where the connected syringe kit (12) is attached to the mixing aid (14, 14a).
    A syringe system (10, 10a) characterized in that.
  8. 　請求項６又は７記載のシリンジシステム（１０、１０ａ）において、
    　前記第１装着部（５４Ａ）及び前記第２装着部（５４Ｂ）は、前記押し子基端部（３０Ａ、３０Ｂ）の基端面を支持するとともに指で押圧される指当部（６２）を有し、
    　前記指当部（６２）の、前記混合補助具（１４、１４ａ）の長手方向と垂直な方向の幅は、前記押し子基端部（３０Ａ、３０Ｂ）の直径（Ｄ）よりも大きく、且つ前記フィンガグリップ（２６Ａ、２６Ｂ）の前記長軸に沿った長さ（Ｌａ、Ｌｂ）よりも小さい、
    　ことを特徴とするシリンジシステム（１０、１０ａ）。     The syringe system (10, 10a) according to claim 6 or 7,
    The first mounting part (54A) and the second mounting part (54B) have a finger contact part (62) that supports the base end face of the pusher base end part (30A, 30B) and is pressed by a finger. And
    The width of the finger holder (62) in the direction perpendicular to the longitudinal direction of the mixing aid (14, 14a) is larger than the diameter (D) of the pusher base end (30A, 30B), and Smaller than the length (La, Lb) along the major axis of the finger grip (26A, 26B),
    A syringe system (10, 10a) characterized in that.
  9. 　請求項６～８のいずれか１項に記載のシリンジシステム（１０、１０ａ）において、
    　前記混合補助具（１４、１４ａ）は、接続状態の前記シリンジキット（１２）を装着可能な第１形態と、前記第１形態よりも全長が短くなった第２形態とに変形可能である、
    　ことを特徴とするシリンジシステム（１０、１０ａ）。     The syringe system (10, 10a) according to any one of claims 6 to 8,
    The mixing aid (14, 14a) can be transformed into a first form in which the syringe kit (12) in a connected state can be mounted and a second form having a shorter overall length than the first form.
    A syringe system (10, 10a) characterized in that.
  10. 　請求項９記載のシリンジシステム（１０ａ）において、
    　前記連結部（５８）は、前記第１装着部（５４Ａ）を有する第１部材（７０）と、前記第２装着部（５４Ｂ）を有する第２部材（７２）とを有し、前記第１部材（７０）と前記第２部材（７２）とはヒンジ部（７４）を介して互いに回動可能に連結されている、
    　ことを特徴とするシリンジシステム（１０ａ）。     The syringe system (10a) according to claim 9,
    The connecting portion (58) includes a first member (70) having the first mounting portion (54A) and a second member (72) having the second mounting portion (54B). The member (70) and the second member (72) are rotatably connected to each other via a hinge portion (74).
    The syringe system (10a) characterized by the above-mentioned.
  11. 　請求項６～１０のいずれか１項に記載のシリンジシステム（１０、１０ａ）において、
    　前記シリンジキット（１２）の初期状態で、前記２つのシリンジ（１６、１８）の少なくとも一方の前記バレル（２０、４０）内の前記ガスケット（２２、４２）よりも先端側に形成された充填空間には空気が入っている、
    　ことを特徴とするシリンジシステム（１０、１０ａ）。     The syringe system (10, 10a) according to any one of claims 6 to 10,
    In the initial state of the syringe kit (12), a filling space formed on the tip side of the gasket (22, 42) in the barrel (20, 40) of at least one of the two syringes (16, 18). Has air in it,
    A syringe system (10, 10a) characterized in that.
  12. 　請求項６～１１のいずれか１項に記載のシリンジシステム（１０、１０ａ）において、
    　前記２つのシリンジ（１６、１８）の前記バレル（２０、４０）の先端部には、互いに螺合可能な螺合用突起部が設けられており、
    　前記バレル（２０、４０）の基端には、径方向外側に突出したフランジ部（２６ｄ、４０ｆ）が設けられ、
    　前記フィンガグリップ（２６Ａ、２６Ｂ）は、前記バレル（２０、４０）の軸を中心に回転可能に前記フランジ部（２６ｄ、４０ｆ）に装着されたグリップ部材（２７Ａ、２７Ｂ）である、
    　ことを特徴とするシリンジシステム（１０、１０ａ）。     The syringe system (10, 10a) according to any one of claims 6 to 11,
    The tip of the barrel (20, 40) of the two syringes (16, 18) is provided with a screwing projection that can be screwed together,
    At the base end of the barrel (20, 40), a flange portion (26d, 40f) projecting radially outward is provided,
    The finger grips (26A, 26B) are grip members (27A, 27B) attached to the flange portions (26d, 40f) so as to be rotatable about the axis of the barrel (20, 40).
    A syringe system (10, 10a) characterized in that.
PCT/JP2018/010994 2017-03-23 2018-03-20 Mixing assistance tool and syringe system WO2018174050A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2019507686A JP6975226B2 (en) 2017-03-23 2018-03-20 Mixing aids and syringe system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2017056807 2017-03-23
JP2017-056807 2017-03-23

Publications (1)

Publication Number Publication Date
WO2018174050A1 true WO2018174050A1 (en) 2018-09-27

Family

ID=63584527

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2018/010994 WO2018174050A1 (en) 2017-03-23 2018-03-20 Mixing assistance tool and syringe system

Country Status (2)

Country Link
JP (1) JP6975226B2 (en)
WO (1) WO2018174050A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111265764A (en) * 2020-03-23 2020-06-12 淄博科创医疗仪器有限公司 Suction and injection dual-purpose injection booster
CN111265764B (en) * 2020-03-23 2024-05-28 淄博科创医疗仪器有限公司 Suction-injection dual-purpose injection booster

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3035820A (en) * 1960-03-23 1962-05-22 Allergy Section Of The Res Fou Emulsification apparatus
US3071351A (en) * 1960-10-25 1963-01-01 Ethan A Brown Emulsor
JPS4970562U (en) * 1972-10-03 1974-06-19
WO2002058834A1 (en) * 2001-01-26 2002-08-01 Howmedica Osteonics Corp. Cement mixing and dispensing device
WO2005118118A2 (en) * 2004-06-02 2005-12-15 William Mccoy Method and apparatus for compounding medications
WO2007083763A1 (en) * 2006-01-23 2007-07-26 Greenpeptide Co., Ltd. Method for production of emulsion preparation comprising physiologically active peptide, and kit for production of the preparation
WO2010027107A1 (en) * 2008-09-05 2010-03-11 オンコセラピー・サイエンス株式会社 Device and method for automatically preparing emulsion drug
JP2013132349A (en) * 2011-12-26 2013-07-08 Daikyo Seiko Ltd Syringe kit for mixing two medicinal fluid

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3035820A (en) * 1960-03-23 1962-05-22 Allergy Section Of The Res Fou Emulsification apparatus
US3071351A (en) * 1960-10-25 1963-01-01 Ethan A Brown Emulsor
JPS4970562U (en) * 1972-10-03 1974-06-19
WO2002058834A1 (en) * 2001-01-26 2002-08-01 Howmedica Osteonics Corp. Cement mixing and dispensing device
WO2005118118A2 (en) * 2004-06-02 2005-12-15 William Mccoy Method and apparatus for compounding medications
WO2007083763A1 (en) * 2006-01-23 2007-07-26 Greenpeptide Co., Ltd. Method for production of emulsion preparation comprising physiologically active peptide, and kit for production of the preparation
WO2010027107A1 (en) * 2008-09-05 2010-03-11 オンコセラピー・サイエンス株式会社 Device and method for automatically preparing emulsion drug
JP2013132349A (en) * 2011-12-26 2013-07-08 Daikyo Seiko Ltd Syringe kit for mixing two medicinal fluid

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111265764A (en) * 2020-03-23 2020-06-12 淄博科创医疗仪器有限公司 Suction and injection dual-purpose injection booster
CN111265764B (en) * 2020-03-23 2024-05-28 淄博科创医疗仪器有限公司 Suction-injection dual-purpose injection booster

Also Published As

Publication number Publication date
JP6975226B2 (en) 2021-12-01
JPWO2018174050A1 (en) 2020-01-23

Similar Documents

Publication Publication Date Title
US10772797B2 (en) Liquid drug transfer devices for use with intact discrete injection vial release tool
JP4150389B2 (en) Injection device
JP4405613B2 (en) Drug delivery pen
JP4599345B2 (en) Drug delivery system and method using the same
US3724460A (en) Disposable cartridge for admixing two components of injectable medicament
JP6880026B2 (en) Medical delivery device
JPH11510087A (en) Delivery method for drugs in drug glass bottles
JP2007143957A (en) Injection apparatus
US8690837B2 (en) Mixing device for a two-chamber ampoule
CN111032124B (en) Auxiliary injection device for injecting a composition contained in a medical container
WO2014004211A1 (en) Multi-compartment pre-filled mixing syringes with bypass
US20180256818A1 (en) Multi chamber syringe unit and method of preparing a multi chamber syringe
KR101788714B1 (en) The injector equipped with two chamber
KR20170021017A (en) Syringe
JP6917493B2 (en) Syringe assembly
WO2018174050A1 (en) Mixing assistance tool and syringe system
JP4579486B2 (en) Prefilled syringe kit
US9295787B2 (en) Adapter means for use in combination with a pre-filled syringe and a safety device, safety device and injection device
CN214050038U (en) Drug delivery device
CA3225738A1 (en) Medical delivery device
WO2019149826A1 (en) Injection device for injecting a composition contained in a medical container
EA044677B1 (en) ADMINISTRATION DEVICE DESIGNED FOR INTRAVITREAL ADMINISTRATION OF FLUID
BR102012031663A2 (en) MIXING SYRINGE

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 18772342

Country of ref document: EP

Kind code of ref document: A1

ENP Entry into the national phase

Ref document number: 2019507686

Country of ref document: JP

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 18772342

Country of ref document: EP

Kind code of ref document: A1