WO2018154118A3 - Nouveaux composés aromatiques - Google Patents

Nouveaux composés aromatiques Download PDF

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Publication number
WO2018154118A3
WO2018154118A3 PCT/EP2018/054686 EP2018054686W WO2018154118A3 WO 2018154118 A3 WO2018154118 A3 WO 2018154118A3 EP 2018054686 W EP2018054686 W EP 2018054686W WO 2018154118 A3 WO2018154118 A3 WO 2018154118A3
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WO
WIPO (PCT)
Prior art keywords
therapy
aromatic compounds
notch signaling
disorders
enhance notch
Prior art date
Application number
PCT/EP2018/054686
Other languages
English (en)
Other versions
WO2018154118A2 (fr
Inventor
Viktoria REINMÜLLER
Original Assignee
Xeniopro GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xeniopro GmbH filed Critical Xeniopro GmbH
Priority to JP2019543962A priority Critical patent/JP7282036B2/ja
Priority to US16/488,458 priority patent/US11591289B2/en
Priority to AU2018223177A priority patent/AU2018223177B2/en
Priority to EP18709290.3A priority patent/EP3585485A2/fr
Publication of WO2018154118A2 publication Critical patent/WO2018154118A2/fr
Publication of WO2018154118A3 publication Critical patent/WO2018154118A3/fr
Priority to US18/064,576 priority patent/US20230406814A2/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne de nouvelles molécules aromatiques utilisables dans le traitement d'affections pathologiques telles que le cancer ou les maladies de la peau; de troubles musculaires et des troubles liés au système immunitaire tels que des troubles du système hématopoïétique, notamment le système hématologique en médecine humaine et vétérinaire.
PCT/EP2018/054686 2017-02-24 2018-02-26 Nouveaux composés aromatiques WO2018154118A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2019543962A JP7282036B2 (ja) 2017-02-24 2018-02-26 新規の芳香族化合物
US16/488,458 US11591289B2 (en) 2017-02-24 2018-02-26 Aromatic compounds
AU2018223177A AU2018223177B2 (en) 2017-02-24 2018-02-26 Aromatic compounds which enhance notch signaling, for use in therapy
EP18709290.3A EP3585485A2 (fr) 2017-02-24 2018-02-26 Composés aromatiques qui améliorent la signalisation de notch, pour une utilisation thérapeutique
US18/064,576 US20230406814A2 (en) 2017-02-24 2022-12-12 Novel aromatic compounds

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201762463212P 2017-02-24 2017-02-24
US62/463,212 2017-02-24
EP17160326 2017-03-10
EP17160326.9 2017-03-10
EP17205950 2017-12-07
EP17205950.3 2017-12-07

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US16/488,458 A-371-Of-International US11591289B2 (en) 2017-02-24 2018-02-26 Aromatic compounds
US18/064,576 Division US20230406814A2 (en) 2017-02-24 2022-12-12 Novel aromatic compounds

Publications (2)

Publication Number Publication Date
WO2018154118A2 WO2018154118A2 (fr) 2018-08-30
WO2018154118A3 true WO2018154118A3 (fr) 2018-12-06

Family

ID=63253169

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2018/054686 WO2018154118A2 (fr) 2017-02-24 2018-02-26 Nouveaux composés aromatiques

Country Status (1)

Country Link
WO (1) WO2018154118A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2019325306A1 (en) * 2018-08-24 2021-02-18 Xeniopro GmbH Phenoxy(hetero)aryl ethers of antiproliferative activity
WO2020039088A2 (fr) * 2018-08-24 2020-02-27 Xeniopro GmbH Nouveaux composés
WO2020039092A2 (fr) * 2018-08-24 2020-02-27 Xeniopro GmbH Nouvelles molécules aromatiques
MX2021011209A (es) * 2019-03-15 2022-01-19 Massachusetts Gen Hospital Novedosos inhibidores de molécula pequeña de factores de transcripción tead.
JP2022550576A (ja) * 2019-10-03 2022-12-02 テナヤ セラピューティクス， インコーポレイテッド ５－フルオロニコチンアミド誘導体およびその使用

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2754286A (en) * 1951-10-15 1956-07-10 Du Pont Aldehydes and their acetals
US3113849A (en) * 1960-06-23 1963-12-10 Dow Chemical Co Solid gels of liquid hydrocarbons containing salts of alkylphenoxybenzoic acids
US3940403A (en) * 1972-05-15 1976-02-24 Shionogi & Co., Ltd. Substituted acetic acid derivatives and production thereof
WO1993003012A1 (fr) * 1991-08-02 1993-02-18 Fujisawa Pharmaceutical Co., Ltd. Derives d'indole
WO1993024442A1 (fr) * 1992-05-29 1993-12-09 Yamanouchi Pharmaceutical Co., Ltd. Medicament renfermant un derive d'acide benzoique, et nouveau derive d'acide benzoique
EP1145718A1 (fr) * 1999-01-22 2001-10-17 Institute of Medicinal Molecular Design, Inc. DERIVES DE DICARBA-closo-DODECABORANE
GB2380193A (en) * 2001-10-01 2003-04-02 Syngenta Ltd Crocacin analogue fungicides
EP1710233A1 (fr) * 2004-01-28 2006-10-11 Kissei Pharmaceutical Co., Ltd. Nouveau derive de benzofurane, composition medicinale contenant celui-ci et utilisations de celles-ci
WO2007022371A2 (fr) * 2005-08-16 2007-02-22 Genzyme Corporation Composes se liant aux recepteurs de chimiokine
WO2009032249A1 (fr) * 2007-09-06 2009-03-12 Merck & Co., Inc. Activateurs de la guanylate cyclase soluble
JP2011001294A (ja) * 2009-06-18 2011-01-06 Sumitomo Chemical Co Ltd アミド化合物及びその植物病害防除用途
WO2013093885A1 (fr) * 2011-12-21 2013-06-27 Ecole polytechnique fédérale de Lausanne (EPFL) Inhibiteurs de la voie de signalisation notch et leur utilisation dans le traitement de cancers
WO2017158190A1 (fr) * 2016-03-17 2017-09-21 Ecole polytechnique fédérale de Lausanne (EPFL) Activateurs de signalisation notch et leur utilisation dans le traitement de cancers et de malignités guérissables par régulation à la hausse de notch
WO2018096510A1 (fr) * 2016-11-28 2018-05-31 Pfizer Inc. Ligands opioïdes kappa hétéroarylphénoxy benzamide

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