WO2018148980A1 - 一种用于动物和体外样本磁共振弹性成像的驱动装置 - Google Patents

一种用于动物和体外样本磁共振弹性成像的驱动装置 Download PDF

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WO2018148980A1
WO2018148980A1 PCT/CN2017/074547 CN2017074547W WO2018148980A1 WO 2018148980 A1 WO2018148980 A1 WO 2018148980A1 CN 2017074547 W CN2017074547 W CN 2017074547W WO 2018148980 A1 WO2018148980 A1 WO 2018148980A1
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animal
magnetic resonance
driving device
resonance elastography
rod
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PCT/CN2017/074547
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French (fr)
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冯原
黄珑
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苏州大学张家港工业技术研究院
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/30—Sample handling arrangements, e.g. sample cells, spinning mechanisms

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  • the present invention relates to external excitation techniques for magnetic resonance elastography, and more particularly to a driving device for magnetic resonance elastography of animals and in vitro samples.
  • Magnetic Resonance Elastography is an imaging technique based on the physical and mechanical properties of biological soft tissue for non-invasive detection. It has been applied to the clinical diagnosis of cirrhosis and is related to the pathological diagnosis of other organ tissues. A lot of applications are being carried out in the direction. The application of small animal models (mouse, rat, etc.) for research and testing is currently the main method for the main clinical application.
  • the working principle of magnetic resonance elastography is to apply an external force to the surface of the object by adding a set of devices that generate mechanical vibration in the magnetic resonance imaging device, to generate displacement of the particles in the medium, and to perform MR imaging on the displacement of the particles.
  • Image processing obtains a spatial distribution map of the elastic coefficients inside the organization. Therefore, the stability and reliability of the vibration excitation device play a vital role in the MRE inspection.
  • the existing magnetic resonance elastography devices for small animals mainly achieve vibration through power transmission.
  • Typical designs include: 1. Arranging piezoelectric sheets through space, and transmitting power with a force transmitting mechanism [1] ; Drive power transmission [2] .
  • the reference is:
  • the driver occupies a large position in the space around the animal, which limits the use in a magnetic resonance instrument with a small diameter
  • the designer actively researches and innovates in order to create a new structure of the driving device for magnetic resonance elastography of animals and in vitro samples, so that it has more industrial value.
  • an object of the present invention is to provide a magnetic structure which is simple in structure, high in space utilization, capable of realizing power transmission in a plane to improve power transmission efficiency, and is commonly used for testing animals of different sizes and other in vitro samples.
  • Resonance elastography drive unit Resonance elastography drive unit.
  • the driving device for magnetic resonance elastography of animal and in vitro samples of the present invention comprises a base on which a piezoelectric actuator and an animal/sample mounting mechanism driven by a piezoelectric actuator are disposed, wherein
  • the piezoelectric actuator comprises a hollow elliptical beam and a piezoelectric ceramic sheet disposed along a long axis of the elliptical beam, the two ends of the piezoelectric ceramic sheet being respectively connected to opposite ends of the elliptical beam corresponding to the long axis thereof, the ellipse Both ends of the short shaft corresponding to the beam are power output ends;
  • the mounting mechanism includes a driver connector coupled to one of the power take-offs, a drive rod coupled to the driver connector, an anesthesia head sleeve sleeved at an end of the drive rod, and two disposed in the Adjusting brackets on both sides of the driving rod for adjusting the animal/sample mounting position, and the ends of the adjusting brackets projecting from the ends of the anesthesia head cover, the adjusting brackets extending out
  • the end of the anesthesia head cover is a fixed end of the animal head, and the fixed end is provided with a plurality of fixing holes.
  • the anesthesia head cover is formed by two side walls, a top wall connecting the tops of the two side walls, and a rear wall connecting the side walls of the two side walls and capable of catching the driving rod, wherein the rear wall is provided
  • a through hole is formed through the two sides thereof, and a conduit for accessing the anesthetic agent is connected to the through hole.
  • the rear wall is provided with a card slot capable of catching the driving rod
  • the top wall is provided with a mounting hole penetrating to the rear wall and communicating with the card slot.
  • the driving rod is further provided on one end of the anesthesia head cover with a nip portion capable of engaging an animal, the occlusal portion including a connecting rod connected to one end of the driving rod and vertically connected with the connecting rod and connected Struts extending on either side of the rod.
  • both ends of the strut are rounded.
  • the driver connector includes a first link connected to one of the power output ends, and two second links respectively connected perpendicularly to both ends of the first link, the first link and the two A space formed by enclosing the two links may be engaged with the other end of the driving rod, and the second connecting rod and the other end of the driving rod are respectively provided with a bolt for passing through Perforation.
  • the other power output end is connected to a fixing plate provided on the base.
  • a threaded hole is disposed on both ends of the corresponding short axis of the elliptical beam, and a short shaft is connected to the two threaded holes as the two power output ends.
  • the elliptical beam is made of aluminum alloy.
  • the base has a semicircular cross section.
  • the present invention has at least the following advantages:
  • the structural arrangement of the piezoelectric ceramic piece and the elliptical beam realizes the transmission of power in the plane and the structure is simple. And space utilization is high;
  • the power is directly transmitted to the tissue part through the elliptical beam and the driving rod, and the power transmission efficiency is high;
  • the driving rod can be engaged with the animal or can be inserted into the external sample container, so that the driving device of the invention is generally used for animal and in vitro sample testing;
  • the position of the animal or the sample container on the pedestal can be adjusted, so that it can be commonly used for in vitro sample testing of animals of different sizes.
  • Figure 1 is a perspective view showing the structure of a driving device of the present invention
  • FIG. 2 is a schematic perspective view showing the anesthesia head cover of the driving device
  • Figure 3 is a perspective view showing the perspective of another angle of the anesthesia head cover in the driving device
  • Figure 4 is a perspective view showing the structure of the driving rod in the driving device
  • Figure 5 is a perspective view showing the structure of the piezoelectric actuator and the driver connector in the driving device
  • Figure 6 is a schematic view of the first embodiment
  • Figure 7 is a schematic view of the second embodiment.
  • a driving device for magnetic resonance elastography of an animal and an in vitro sample includes a base 10 having a semicircular cross section, and a base 10 is disposed on the base 10. Piezoelectric drive And an animal/sample mounting mechanism driven by a piezoelectric actuator.
  • the piezoelectric actuator includes a hollow elliptical beam 21 and a piezoelectric ceramic sheet 22 disposed along a long axis of the elliptical beam 21, and two ends of the piezoelectric ceramic sheet 22 are respectively connected to opposite ends of the elliptical beam 21 corresponding to the long axis thereof,
  • the two ends of the corresponding short axis of the elliptical beam 2 are the power output end 23;
  • the mounting mechanism includes a driver connector 31 connected to one of the power output ends 23, a driving rod 32 connected to the driver connector 31, and a driving rod 32.
  • the adjustment bracket 34 extends from the end of the anesthesia head cover 33 to the fixed end of the animal head, and the fixed end is provided with a plurality of fixing holes 35.
  • the elliptical beam 21 is made of an aluminum alloy material, and the piezoelectric ceramic sheet 22 is placed along the elliptical long axis, and the piezoelectric ceramic sheet 22 is contracted under voltage excitation to generate strain along the long axis direction of the elliptical beam 21.
  • the elliptical beam 21 is contracted or stretched in the long axis direction, the short axis direction produces a corresponding stretching or contraction motion.
  • the piezoelectric ceramic piece 22 is excited by the alternating voltage, the periodic motion in the long axis direction is converted into the periodic motion in the short axis direction and is transmitted through the power output terminal 23.
  • the present invention has a threaded hole 211 at both ends of the corresponding short axis of the elliptical beam 21, and a short shaft 212 is connected to the two threaded holes 211 as two power output ends 23,
  • One of the short shafts is coupled to the fixed plate 11 disposed on the base 10, the short shaft is fixed, and the other short shaft is coupled to the drive connecting member 31, and the drive link 32 is driven to move the drive rod 32.
  • the driver connector 31 of the present invention includes a first link 311 connected to one of the power output ends 23, and the first link respectively.
  • the two second links 312 vertically connected at both ends of the 311, the space formed by the enclosing between the first link 311 and the two second links 312 can catch the end of the driving rod 32, and the two second links 312 and the driving Corresponding locations on the other end of the rod 32 are provided with perforations 313 for the passage of bolts.
  • the end of the drive rod 32 is snapped into the driver connector 31, and the perforations 313 are correspondingly engaged by bolts.
  • the drive rod 32 can be connected to the driver connector 31 through the locking of each of the through holes 313 to realize power transmission.
  • the anesthesia head cover 33 of the present invention comprises two side walls 331, a top wall 332 connecting the tops of the two side walls 331, and a rear wall 333 connecting the sides of the side walls 331 and capable of catching the driving rod 32.
  • the rear wall 333 is provided with a through hole 334 extending through the two sides thereof, and the through hole 334 is connected with a conduit 335 for accessing the anesthetic agent.
  • the animal's head is inserted into the anesthesia headgear 33, fixed by the anesthesia headgear 33, and the anesthetic agent is introduced into the catheter 335 to anesthetize the animal.
  • the fastening hole 35 can be selectively attached to the fixing hole 35 of the adjustment bracket 34 to fix the animal head to the fixed end of the animal head again.
  • the rear wall 333 of the anesthesia head cover 33 of the present invention is provided with a card slot 336 capable of catching the driving rod 32
  • the top wall 332 is provided with a through wall 333 and A mounting hole 337 that communicates with the card slot 336.
  • the structure of the drive rod 32 can be adjusted according to the test object.
  • a occlusion portion capable of engaging the animal may be disposed on the end of the driving rod 32 at the anesthesia head cover 33.
  • the occlusal portion includes a connecting rod 321 connected to the end of the driving rod 32 and is perpendicular to the connecting rod 321 A strut 323 that is coupled to and extends from opposite sides of the link 321 .
  • the occlusal portion formed by the connecting rod 321 and the stay 323 allows the animal to bite, so that after the animal is fixed, the animal mouth engages the occlusal portion to perform elastography.
  • both ends of the stay 323 are rounded.
  • test object is an in vitro sample
  • the structure of the driving rod does not limit the above situation, and other types of driving rods may be used instead of the driver connecting member, as long as the sample or animal vibration can be driven.
  • the mouse magnetic resonance elastography test as shown in Fig. 6, the mouse 300's abdomen is facing downward, the limbs are opened and closed on the body side, the position of the animal on the pedestal is adjusted by adjusting the stent, and the mouse mouth is opened.
  • the part of the tooth is engaged with the occlusal part of the driving rod, the anesthesia headgear is placed over the head of the mouse, and the mouth and nose parts of the head of the mouse are completely covered.
  • the abdomen of the mouse is padded to the same level as the driving rod.
  • the driving device 100 and the mouse 300 are simultaneously placed in the coil 200 and placed in the magnetic resonance scanning cavity, and the driving line of the driving device 100 and the anesthesia crown are taken out from the driving device to the accessory device for magnetic resonance elastography.
  • the sample magnetic resonance elastography test places the sample 400 in the sample container 500 and inserts the end of the drive rod 32 into the sample.
  • the drive rod 32 can machine additional extensions depending on the sample depth dimension.
  • the position of the sample container 400 is connected to the drive unit 100 via an adjustment bracket. If the sample container is small in size, the bottom of the sample container can be raised to the same level as the drive rod 32.
  • the sample is placed in the coil 200 with the drive unit, and the drive line of the drive unit 100 and the anesthesia crown are led from the drive unit to an accessory device for magnetic resonance elastography.

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Abstract

一种用于动物和体外样本磁共振弹性成像的驱动装置，包括基座（10），基座（10）上设有压电驱动器和由压电驱动器驱动的动物/样本安装机构，其中压电驱动器包括中空的椭圆梁（21）和沿椭圆梁（21）的长轴设置的压电陶瓷片（22），压电陶瓷片（22）的两端分别与椭圆梁（21）对应其长轴的两端连接，椭圆梁（21）对应的短轴的两端为动力输出端（23）；安装机构包括与其中一个动力输出端（23）连接的驱动器连接件（31）、与驱动器连接件（31）连接的驱动杆（32）、套设在驱动杆（32）端部的麻醉头套（33），以及两设置在基座（10）上分别位于驱动杆（32）两侧、用于调整动物/样本安装位置的调节支架（34），两调节支架（34）的端部伸出麻醉头套（33）的端部，调节支架（34）伸出麻醉头套（33）的端部为动物头部固定端，固定端上设有若干固定孔（35）。驱动装置结构简单、动力传输效率较高。

Description

一种用于动物和体外样本磁共振弹性成像的驱动装置 技术领域
本发明涉及磁共振弹性成像的外部激励技术，尤其涉及一种用于动物和体外样本磁共振弹性成像的驱动装置。
背景技术
磁共振弹性成像(Magnetic Resonance Elastography，MRE)方法是一种基于生物软组织物理力学特性进行无创检测的影像技术，目前已在针对肝硬化的临床诊断方面开展应用，并在其他器官组织的病理诊断相关方向开展大量应用。应用小动物模型(小鼠、大鼠等)进行研究与测试是目前主要的临床应用前期的主要方法。
磁共振弹性成像技术的工作原理是通过在磁共振成像设备中附加一套产生机械震动的装置，在被检体的表面施加外力，产生介质内质点的位移，对质点的位移进行MR成像，通过图像处理获得组织内部的弹性系数空间分布图。故振动激发装置的稳定性及可靠性在MRE检查中起着至关重要的作用。
现有针对小动物的磁共振弹性成像装置主要通过动力传递实现振动，典型设计包括：1、通过空间布置压电片，配合传力机构进行动力传递[1]；2、通过连杆机构进行电磁驱动动力传递[2]。参考文献为：
[1]Boulet,T.,M.L.Kelso,and S.F.Othman,Long-Term In Vivo Imaging of Viscoelastic Properties of the Mouse Brain after Controlled Cortical Impact.Journal of Neurotrauma,2013.30(17):p.1512-1520.
[2]Murphy,M.C.,et al.,Magnetic resonance elastography of the brain in a  mouse model of Alzheimer's disease:initial results.Magnetic resonance imaging,2012.30(4):p.535-539.
压电驱动型磁兼容性很好，使用广泛，但存在一下缺点：
1、需要额外的动力传递机构进行运动传输，无法将驱动器运动直接传递到测试组织部位，动力传输效率低；
2、驱动器在动物周围空间占据位置较大，限制了在口径较小的磁共振仪中的使用；
3、仅针对小动物，无法直接应用于体积较大的大动物实验或其他体外样本。
有鉴于上述的缺陷，本设计人，积极加以研究创新，以期创设一种新型结构的用于动物和体外样本磁共振弹性成像的驱动装置，使其更具有产业上的利用价值。
发明内容
为解决上述技术问题，本发明的目的是提供一种结构简单、空间利用率高，能够在平面内实现动力传递以提高动力传输效率，并通用于不同尺寸的大小动物以及其他体外样本测试的磁共振弹性成像的驱动装置。
本发明的用于动物和体外样本磁共振弹性成像的驱动装置，包括基座，所述基座上设有压电驱动器和由压电驱动器驱动的动物/样本安装机构，其中
-所述压电驱动器包括中空的椭圆梁和沿椭圆梁的长轴设置的压电陶瓷片，所述压电陶瓷片的两端分别与所述椭圆梁对应其长轴的两端连接，所述椭圆梁对应的短轴的两端为动力输出端；
-所述安装机构包括与其中一个所述动力输出端连接的驱动器连接件、与驱动器连接件连接的驱动杆、套设在驱动杆端部的麻醉头套，以及两设置在所述 基座上分别位于所述驱动杆两侧、用于调整动物/样本安装位置的调节支架，两所述调节支架的端部伸出所述麻醉头套的端部，所述调节支架伸出所述麻醉头套的端部为动物头部固定端，所述固定端上设有若干固定孔。
进一步的，所述麻醉头套由两侧壁、连接两侧壁顶部的顶壁以及连接两侧壁侧部并能卡住所述驱动杆的后壁围合而成，所述后壁上设有贯穿其两侧的通孔，所述通孔上连接有用于接入***剂的导管。
进一步的，所述后壁上设有能够将所述驱动杆卡住的卡槽，所述顶壁上设有贯穿至所述后壁并与所述卡槽连通的安装孔。
进一步的，所述驱动杆位于所述麻醉头套的一端上还设有能够让动物咬合的咬合部，所述咬合部包括与所述驱动杆一端连接的连杆以及与连杆垂直连接并相对连杆两侧延伸的撑杆。
进一步的，所述撑杆的两端均倒圆角。
进一步的，所述驱动器连接件包括与其中一个所述动力输出端连接的第一连杆、分别与第一连杆两端垂直连接的两第二连杆，所述第一连杆与两第二连杆之间围合形成的空间可以卡住所述驱动杆的另一端，两所述第二连杆与所述驱动杆的另一端上相应的位置上均设有能有供螺栓穿过的穿孔。
进一步的，另一个所述动力输出端与设置在所述基座上的固定板连接。
进一步的，所述椭圆梁对应的短轴的两端上设有螺纹孔，并在两螺纹孔上连接短轴作为两所述动力输出端。
进一步的，所述椭圆梁为铝合金材质。
进一步的，所述基座的截面为半圆形。
借由上述方案，本发明至少具有以下优点：
1、压电陶瓷片与椭圆梁的结构布置，实现了在平面内传递动力，结构简单 且空间利用率高；
2、通过椭圆梁与驱动杆直接将动力传递到组织部位，动力传输效率高；
3、驱动杆既可以与动物咬合配合，也可***体外样本容器中，使得本发明的驱动装置通用于动物与体外样本测试；
4、通过调节支架，可以调节动物或样本容器在基座上的位置，从而能够通用于不同尺寸的大小动物于体外样本测试。
上述说明仅是本发明技术方案的概述，为了能够更清楚了解本发明的技术手段，并可依照说明书的内容予以实施，以下以本发明的较佳实施例并配合附图详细说明如后。
附图说明
图1是本发明的驱动装置的立体结构示意图；
图2是驱动装置中麻醉头套的立体结构示意图；
图3是驱动装置中麻醉头套另一角度的立体结构示意图；
图4是驱动装置中驱动杆的立体结构示意图；
图5是驱动装置中压电驱动器与驱动器连接件的立体结构示意图；
图6是实施例一的示意图；
图7是实施例二的示意图。
具体实施方式
下面结合附图和实施例，对本发明的具体实施方式作进一步详细描述。以下实施例用于说明本发明，但不用来限制本发明的范围。
参见图1至图5，本发明一较佳实施例所述的一种用于动物和体外样本磁共振弹性成像的驱动装置，包括截面为半圆形的基座10，基座10上设有压电驱动 器和由压电驱动器驱动的动物/样本安装机构。具体的，压电驱动器包括中空的椭圆梁21和沿椭圆梁21的长轴设置的压电陶瓷片22，压电陶瓷片22的两端分别与椭圆梁21对应其长轴的两端连接，椭圆梁2对应的短轴的两端为动力输出端23；安装机构包括与其中一个动力输出端23连接的驱动器连接件31、与驱动器连接件31连接的驱动杆32、套设在驱动杆32端部的麻醉头套33，以及两设置在基座10上分别位于驱动杆32两侧、用于调整动物/样本安装位置的调节支架34，两调节支架34的端部伸出麻醉头套33的端部，调节支架34伸出麻醉头套33的端部为动物头部固定端，固定端上设有若干固定孔35。
本发明中椭圆梁21由铝合金材料制成，将压电陶瓷片22沿椭圆长轴放置，压电陶瓷片22在电压激励下产生收缩，产生沿椭圆梁21长轴方向的应变。当椭圆梁21在长轴方向收缩或拉伸运动时，短轴方向产生相应的拉伸或收缩运动。当压电陶瓷片22受到交变电压的激励时，长轴方向的周期运动转化为短轴方向的周期运动，并通过动力输出端23传出。为使本发明的驱动装置在平面内传递动力，本发明在椭圆梁21对应的短轴的两端上开设螺纹孔211，并在两螺纹孔211上连接短轴212作为两动力输出端23，将其中一个短轴与设置在基座10上的固定板11连接，将该短轴限定不动，另一个短轴与驱动连接件31连接，由驱动连接件31带动驱动杆32运动。
具体的，为使动物/样本安装机构与压电驱动器处于同一个平面上，本发明中的驱动器连接件31包括与其中一个动力输出端23连接的第一连杆311、分别与第一连杆311两端垂直连接的两第二连杆312，第一连杆311与两第二连杆312之间围合形成的空间可以卡住驱动杆32的端部，两第二连杆312与驱动杆32的另一端上相应的位置上均设有能有供螺栓穿过的穿孔313。安装时，将驱动杆32的端部卡进驱动器连接件31内，并使各穿孔313相对应，利用螺栓穿 过各穿孔313锁紧即可将驱动杆32与驱动器连接件31连接，实现动力传递。
为了方便麻醉并固定动物头部，本发明中麻醉头套33由两侧壁331、连接两侧壁331顶部的顶壁332以及连接两侧壁331侧部并能卡住驱动杆32的后壁333围合而成，后壁333上设有贯穿其两侧的通孔334，通孔334上连接有用于接入***剂的导管335。将动物的头部伸进麻醉头套33内，由麻醉头套33固定，将***剂通入导管335对动物进行麻醉。为加强对动物头部的固定，可选择性的用紧固螺栓安装在调节支架34上的固定孔35上，将动物头部再次固定在动物头部固定端上。
为使麻醉头套33能够随驱动杆32运动，本发明中麻醉头套33的后壁333上设有能够将驱动杆32卡住的卡槽336，在顶壁332上设有贯穿至后壁333并与卡槽336连通的安装孔337。安装麻醉头套33时，将卡槽336卡住驱动杆32，利用螺栓穿过安装孔337将麻醉头套33锁紧在驱动杆32上即可。
本发明中，驱动杆32的结构可根据测试对象进行调整。测试对象为小动物时，可在驱动杆32位于麻醉头套33的端部上还设置能够让动物咬合的咬合部，咬合部包括与驱动杆32端部连接的连杆321以及与连杆321垂直连接并相对连杆321两侧延伸的撑杆323。利用连杆321与撑杆323形成的咬合部，可使动物咬住，从而在动物固定后，动物嘴巴咬合该咬合部，即可进行弹性成像。
为减小咬合过程中对动物的伤害，本发明中，撑杆323的两端均倒圆角。
当测试对象为体外样本时，只需使驱动杆32的长度能够深入固定好的样本容器内即可。
当然，驱动杆的结构并不限制以上所述情况，也可改用其他形式的驱动杆与驱动器连接件连接，只要能实现带动样本或动物振动即可。
下面通过两个实施例来说明本发明的具体使用方法。
实施例一
小鼠磁共振弹性成像测试，如图6所示，将小鼠300的腹部朝下，四肢张开后收在体侧，动物在基座上的位置通过调节支架进行调节，张开小鼠嘴部将牙齿与驱动杆的咬合部咬合，将麻醉头套套入小鼠头部并将小鼠头部嘴鼻部分完全覆盖，小鼠的腹部用棉球垫高至与驱动杆同一水平位置。将驱动装置100与小鼠300同时放入线圈200中，并置于磁共振扫描腔体内，驱动装置100的驱动线和麻醉冠从驱动装置引出连接至磁共振弹性成像的附属设备。
实施例二
样本磁共振弹性成像测试，如图7所示，将样本400置于样本容器500中，并将驱动杆32的端部***样本中。驱动杆32可根据样本深度尺寸加工额外的延伸段。样本容器400的位置通过调节支架与驱动装置100连接。如样本容器尺寸较小，可将样本容器底部垫高至与驱动杆32同一水平位置。样本与驱动装置同置于线圈200中，驱动装置100的驱动线和麻醉冠从驱动装置引出连接至磁共振弹性成像的附属设备。
以上所述仅是本发明的优选实施方式，并不用于限制本发明，应当指出，对于本技术领域的普通技术人员来说，在不脱离本发明技术原理的前提下，还可以做出若干改进和变型，这些改进和变型也应视为本发明的保护范围。

Claims (10)

  1. 一种用于动物和体外样本磁共振弹性成像的驱动装置，其特征在于：包括基座，所述基座上设有压电驱动器和由压电驱动器驱动的动物/样本安装机构，其中
    -所述压电驱动器包括中空的椭圆梁和沿椭圆梁的长轴设置的压电陶瓷片，所述压电陶瓷片的两端分别与所述椭圆梁对应其长轴的两端连接，所述椭圆梁对应的短轴的两端为动力输出端；
    -所述安装机构包括与其中一个所述动力输出端连接的驱动器连接件、与驱动器连接件连接的驱动杆、套设在驱动杆端部的麻醉头套，以及两设置在所述基座上分别位于所述驱动杆两侧、用于调整动物/样本安装位置的调节支架，两所述调节支架的端部伸出所述麻醉头套的端部，所述调节支架伸出所述麻醉头套的端部为动物头部固定端，所述固定端上设有若干固定孔。
  2. 根据权利要求1所述的用于动物和体外样本磁共振弹性成像的驱动装置，其特征在于：所述麻醉头套由两侧壁、连接两侧壁顶部的顶壁以及连接两侧壁侧部并能卡住所述驱动杆的后壁围合而成，所述后壁上设有贯穿其两侧的通孔，所述通孔上连接有用于接入***剂的导管。
  3. 根据权利要求2所述的用于动物和体外样本磁共振弹性成像的驱动装置，其特征在于：所述后壁上设有能够将所述驱动杆卡住的卡槽，所述顶壁上设有贯穿至所述后壁并与所述卡槽连通的安装孔。
  4. 根据权利要求3所述的用于动物和体外样本磁共振弹性成像的驱动装置，其特征在于：所述驱动杆位于所述麻醉头套的一端上还设有能够让动物咬合的咬合部，所述咬合部包括与所述驱动杆一端连接的连杆以及与连杆垂直连接并相对连杆两侧延伸的撑杆。
  5. 根据权利要求4所述的用于动物和体外样本磁共振弹性成像的驱动装 置，其特征在于：所述撑杆的两端均倒圆角。
  6. 根据权利要求4所述的用于动物和体外样本磁共振弹性成像的驱动装置，其特征在于：所述驱动器连接件包括与其中一个所述动力输出端连接的第一连杆、分别与第一连杆两端垂直连接的两第二连杆，所述第一连杆与两第二连杆之间围合形成的空间可以卡住所述驱动杆的另一端，两所述第二连杆与所述驱动杆的另一端上相应的位置上均设有能有供螺栓穿过的穿孔。
  7. 根据权利要求6所述的用于动物和体外样本磁共振弹性成像的驱动装置，其特征在于：另一个所述动力输出端与设置在所述基座上的固定板连接。
  8. 根据权利要求7所述的用于动物和体外样本磁共振弹性成像的驱动装置，其特征在于：所述椭圆梁对应的短轴的两端上设有螺纹孔，并在两螺纹孔上连接短轴作为两所述动力输出端。
  9. 根据权利要求8所述的用于动物和体外样本磁共振弹性成像的驱动装置，其特征在于：所述椭圆梁为铝合金材质。
  10. 根据权利要求1-9任一项所述的用于动物和体外样本磁共振弹性成像的驱动装置，其特征在于：所述基座的截面为半圆形。
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