WO2018096375A3 - Méthode de détermination de l'état réceptif de l'endomètre - Google Patents

Méthode de détermination de l'état réceptif de l'endomètre Download PDF

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Publication number
WO2018096375A3
WO2018096375A3 PCT/HU2017/050049 HU2017050049W WO2018096375A3 WO 2018096375 A3 WO2018096375 A3 WO 2018096375A3 HU 2017050049 W HU2017050049 W HU 2017050049W WO 2018096375 A3 WO2018096375 A3 WO 2018096375A3
Authority
WO
WIPO (PCT)
Prior art keywords
receptive
endometrium
determination
status
relates
Prior art date
Application number
PCT/HU2017/050049
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English (en)
Other versions
WO2018096375A2 (fr
Inventor
Bálint László BÁLINT
Original Assignee
Quantbio Kft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU1600636A external-priority patent/HUP1600636A2/hu
Priority claimed from HU1600637A external-priority patent/HUP1600637A2/hu
Application filed by Quantbio Kft filed Critical Quantbio Kft
Priority to EP17857649.2A priority Critical patent/EP3545107A2/fr
Publication of WO2018096375A2 publication Critical patent/WO2018096375A2/fr
Publication of WO2018096375A3 publication Critical patent/WO2018096375A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D19/00—Instruments or methods for reproduction or fertilisation
    • A61D19/04—Instruments or methods for reproduction or fertilisation for embryo transplantation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Reproductive Health (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Transplantation (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne une méthode de détermination de l'état réceptif ou non réceptif de l'endomètre à l'aide d'un échantillon biologique prélevé chez un sujet en âge de procréer, de préférence une patiente humaine. De plus, l'invention concerne un kit de test approprié pour la mise en œuvre de la méthode, ainsi que l'utilisation d'oligonucléotides appropriés pour l'amplification d'ensembles de gènes permettant la détermination de l'état réceptif ou non réceptif de l'endomètre.
PCT/HU2017/050049 2016-11-22 2017-11-22 Méthode de détermination de l'état réceptif de l'endomètre WO2018096375A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP17857649.2A EP3545107A2 (fr) 2016-11-22 2017-11-22 Méthode de détermination de l'état réceptif de l'endomètre

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
HU1600636A HUP1600636A2 (en) 2016-11-22 2016-11-22 Process for determining receptive status of endometrium
HU1600637A HUP1600637A2 (en) 2016-11-22 2016-11-22 Process for determining receptive status of endometrium
HUP1600636 2016-11-22
HUP1600637 2016-11-22

Publications (2)

Publication Number Publication Date
WO2018096375A2 WO2018096375A2 (fr) 2018-05-31
WO2018096375A3 true WO2018096375A3 (fr) 2018-10-04

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/HU2017/050049 WO2018096375A2 (fr) 2016-11-22 2017-11-22 Méthode de détermination de l'état réceptif de l'endomètre

Country Status (2)

Country Link
EP (1) EP3545107A2 (fr)
WO (1) WO2018096375A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019246160A2 (fr) * 2018-06-18 2019-12-26 Igenomix, S.L. Méthodes, compositions et kits pour l'évaluation de la transformation de l'endomètre
CN110042156B (zh) * 2019-04-22 2021-12-28 苏州亿康医学检验有限公司 一种判断子宫内膜容受性的方法及其应用
WO2020234026A1 (fr) * 2019-05-17 2020-11-26 Tervisetehnoloogiate Arenduskeskus As Détermination de la réceptivité endométriale
EP3779455A1 (fr) * 2019-08-14 2021-02-17 Asociación Centro de Investigación Cooperativa en Biociencias - CIC bioGUNE Signatures lipidiques pour déterminer le résultat de l'implantation d'un embryon pendant la fertilisation in vitro
CN110846400A (zh) * 2019-10-30 2020-02-28 吉林大学 人外周血循环FST mRNA检测试剂盒及其用途
KR102640230B1 (ko) * 2021-09-24 2024-02-22 가천대학교 산학협력단 C-peptide를 처리한 자궁내막 기질세포의 이동성 변화 기작을 이용한 자궁내막 관련질환의 진단 방법 및 자궁내막 관련질환 치료제의 스크리닝 방법
CN115418340A (zh) * 2022-06-09 2022-12-02 中南大学湘雅医院 人宫腔灌洗液来源的子宫内膜类器官的培养方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2348318A1 (fr) * 2010-01-21 2011-07-27 Equipo Ivi Investigación, S.L. Procédé de diagnostic pour la réceptivité endométriale
WO2013135836A1 (fr) * 2012-03-14 2013-09-19 Centre Hospitalier Universitaire Pontchaillou Itih5 comme marqueur de diagnostic de développement utérin et de défauts fonctionnels

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2348318A1 (fr) * 2010-01-21 2011-07-27 Equipo Ivi Investigación, S.L. Procédé de diagnostic pour la réceptivité endométriale
WO2013135836A1 (fr) * 2012-03-14 2013-09-19 Centre Hospitalier Universitaire Pontchaillou Itih5 comme marqueur de diagnostic de développement utérin et de défauts fonctionnels

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
ALISON S. DEVONSHIRE ET AL: "Application of next generation qPCR and sequencing platforms to mRNA biomarker analysis", METHODS, vol. 59, no. 1, 1 January 2013 (2013-01-01), US, pages 89 - 100, XP055228123, ISSN: 1046-2023, DOI: 10.1016/j.ymeth.2012.07.021 *
ANNA P. PONNAMPALAM ET AL: "Molecular classification of human endometrial cycle stages by transcriptional profiling", MOLECULAR HUMAN REPRODUCTION., vol. 10, no. 12, 1 December 2004 (2004-12-01), GB - BE, pages 879 - 893, XP055471232, ISSN: 1360-9947, DOI: 10.1093/molehr/gah121 *
DELPHINE HAOUZI ET AL: "Insights into human endometrial receptivity from transcriptomic and proteomic data", REPRODUCTIVE BIOMEDICINE ONLINE, ELSEVIER, AMSTERDAM, NL, vol. 24, no. 1, 15 September 2011 (2011-09-15), pages 23 - 34, XP028122046, ISSN: 1472-6483, [retrieved on 20110929], DOI: 10.1016/J.RBMO.2011.09.009 *
DIAZ-GIMENO P ET AL: "A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature", FERTILITY AND STERILITY, vol. 95, no. 1, 1 January 2011 (2011-01-01), pages 50 - 60.e15, XP027563196, ISSN: 0015-0282, [retrieved on 20100708] *
GIUDICE LINDA C: "Application of functional genomics to primate endometrium: insights into biological processes", REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, vol. 4, no. Suppl 1, S4, 9 October 2006 (2006-10-09), XP021024770, ISSN: 1477-7827, DOI: 10.1186/1477-7827-4-S1-S4 *
MARIA RUIZ-ALONSO ET AL: "The genomics of the human endometrium", BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE., vol. 1822, no. 12, 1 December 2012 (2012-12-01), NL, pages 1931 - 1942, XP055471229, ISSN: 0925-4439, DOI: 10.1016/j.bbadis.2012.05.004 *
TALBI S ET AL: "Molecular phenotyping of human endometrium distinguishes menstrual cycle phases and underlying biological processes in normo-ovulatory women", ENDOCRINOLOGY, THE ENDOCRINE SOCIETY, US, vol. 147, no. 3, 1 March 2006 (2006-03-01), pages 1097 - 1121, XP002595772, ISSN: 0013-7227, [retrieved on 20060301], DOI: 10.1210/EN.2005-1076 *
VILELLA F ET AL: "Endometrial fluid transcriptomics as a new non-invasive diagnostic method of uterine receptivity", FERTILITY AND STERILITY, vol. 108, no. 3, 31 October 2017 (2017-10-31), XP085158410, ISSN: 0015-0282, DOI: 10.1016/J.FERTNSTERT.2017.07.156 *
ZEYNEP H GUMUS: "Wafergen Biosystems SmartChip Human Oncology Panel v2", 1 July 2012 (2012-07-01), pages 1 - 31, XP055495306, Retrieved from the Internet <URL:https://www.ebi.ac.uk/arrayexpress/files/A-GEOD-14610/A-GEOD-14610.adf.txt> [retrieved on 20180725] *

Also Published As

Publication number Publication date
WO2018096375A2 (fr) 2018-05-31
EP3545107A2 (fr) 2019-10-02

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