WO2018069329A1 - Production of re-188/186 particles - Google Patents
Production of re-188/186 particles Download PDFInfo
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- WO2018069329A1 WO2018069329A1 PCT/EP2017/075826 EP2017075826W WO2018069329A1 WO 2018069329 A1 WO2018069329 A1 WO 2018069329A1 EP 2017075826 W EP2017075826 W EP 2017075826W WO 2018069329 A1 WO2018069329 A1 WO 2018069329A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
- A61K51/1244—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins microparticles or nanoparticles, e.g. polymeric nanoparticles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
- A61K51/1244—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins microparticles or nanoparticles, e.g. polymeric nanoparticles
- A61K51/1251—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins microparticles or nanoparticles, e.g. polymeric nanoparticles micro- or nanospheres, micro- or nanobeads, micro- or nanocapsules
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1028—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy using radiation sources applied onto the body
- A61N5/1029—Radioactive dressings
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- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/04—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators
- G21G1/06—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators by neutron irradiation
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- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21H—OBTAINING ENERGY FROM RADIOACTIVE SOURCES; APPLICATIONS OF RADIATION FROM RADIOACTIVE SOURCES, NOT OTHERWISE PROVIDED FOR; UTILISING COSMIC RADIATION
- G21H1/00—Arrangements for obtaining electrical energy from radioactive sources, e.g. from radioactive isotopes, nuclear or atomic batteries
- G21H1/06—Cells wherein radiation is applied to the junction of different semiconductor materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N2005/1019—Sources therefor
Definitions
- the present invention relates to a process for producing and optimizing rhenium- containing, non-volatile and water-insoluble particles under non-radioactive conditions and activating said particles to obtain radioactive rhenium compounds with reduced risk of radioactive tungsten impurities.
- the activated particles according to the present invention and compositions comprising such particles are useful for medical applications and cosmetic purposes.
- squamous cells There are three main types of cells in the top layer of the skin (i.e. the epidermis): squamous cells, basal cells and melanocytes.
- the most common type of skin cancer is basal cell carcinoma (BCC) usually developing on sun-exposed areas such as the head and neck.
- SCC also appears on sun-exposed areas of the body such as the face, ears, neck, lips, cleavage, back, legs, feet, and hands. SCC can also develop in scars or chronic skin sores and the skin of the genital area.
- Melanomas are much less common than BCC and SCC. Worldwide several millions of people are diagnosed with non-melanoma skin cancer each year [1-4] and thousands of people die.
- Naturally occurring rhenium has only one stable isotope, 185 Re, which occurs in minority abundance of 37%.
- the major natural isotope is 187 Re (63%), which is unstable but has a long half-life (i.e. 41.2*10 9 years).
- 186 Re and 188 Re are artificial isotopes that are used, for example, as radioactive tracer and for other applications in nuclear medicine.
- the beta-emitter 188 Re has proved to be an ideal choice as a radioactive source for radionuclide therapy.
- 188 Re has a half-life of about 17 hours and the average penetration of its irradiation into the skin is about 2-3 mm (92% of its deposited dose is below 3mm depth). This is sufficient to treat most BCC and SCC without damaging lower layers of the skin and underlying tissue.
- 188 Re also emits to about 15% gamma-irradiation of 155 keV which enables the use of standard nuclear medicine technologies to detect potential contamination.
- the beta-emitter 186 Re as well is an excellent choice as a radioactive source for radionuclide therapy.
- 186 Re has a half-life of about 89.25 hours and the average penetration of its irradiation into the skin is about 1-1.2 mm (94% of its deposited dose is below 1mm depth). This is sufficient to treat thin BCC and SCC or BCC and SCC located in areas with thin skin (e.g. eye lids, ears) or mucous membranes (lips, genitals) without damaging lower layers of the underlying tissue. .
- 188 Re is generated using 188 W/ 188 Re generators.
- Clinics which are able to offer a treatment with 188 Re have their own 188 188 generators, and accordingly 188 Re is generated at the location where it is subsequently used in therapy.
- the current method therefore provides short paths, which is particularly advantageous in view of the short half-life of about 17 hours of 188 Re.
- the possibility to generate 188 Re on-site therefore has been considered as an essential practical requirement for the use of 188 Re in radionuclide therapy.
- the current method of producing the radioactive source has certain disadvantages.
- the solution when eluting 188 Re from the generator, the solution always contains 188 W impurities. Due to the long half-life of 188 W (about 70 days) such impurities are of significant concern when it comes to the disposal of radioactive waste.
- the amount of 188 W impurities varies from generator to generator and amounts increase over the life time of the generator. Additionally, mishandling of the generator might cause sudden increase of 1 1 8 0 8 0 W impurities (i.e. 188 W passes to the 188 Re solution).
- 188 W impurities can be detected after several half-lives of 188 Re on the basis of the longer half-life. However, this leads to a loss of already limited amounts of radioactivity during the time of waiting prior to the measurement.
- 188 W/ 188 Re generators decaying to 188 Re requires a double neutron capture route. This impedes the availability of 188 Re, since 188 W at adequate specific activity can be prepared only in as little as three high flux reactors operating in the World.
- 188 W can be detected only afterwards with potentially serious consequences regarding radioactive waste management.
- reactions to transfer the eluted 188 Re into stable, non-volatile compounds require specific laboratory facilities guaranteeing for radiation safety.
- the production line needs to be cleaned from residual radioactivity. Due to radiation protection, this can only be done at the earliest two days after production.
- using generators also constrains the maximum radioactivity per volume unit that can be eluted, which may result in too low radioactive yield for practical means.
- Figure 1 shows a distribution of particle sizes for Re 2 S7 obtained by a process according to the invention. There is a single peak with a narrow spread. The average size may be adjusted as needed.
- Figure 2 shows a distribution of particle sizes for Re 2 S 7 obtained by the process of the comparative example, i.e. according to the conservative method. At least three peaks can be seen, all of them being more than an order of magnitude away. The peaks are also broader than in Figure 1.
- particles refers to particulate matter such as atoms, clusters of atoms or molecules of single or multiple elements. In general, there is no restriction regarding the quantity of matter forming a particle.
- starting particles is used herein to refer to particles prior to activation according to the present invention.
- the term starting particles as used in context of the present invention refers to non-radioactive particles.
- a preferred size range of the starting particles is about 1 nanometer to 100 micrometers, such as from 10 nanometers to 20 micrometers, from 20 nanometers to 10 micrometers, from 50 nanometers to 5 micrometers, or from 100 nanometers to 1 micrometer.
- the starting particles according to the present invention are non-volatile and water-insoluble.
- non-volatile refers to particles having a low tendency to vaporize. This means, the starting particles may have a vapor pressure below 100 Pa at 20°C.
- water-insoluble is used herein to refer to particles being poorly soluble in water, i.e. having a solubility in water below 0.1 g per 100 g of water at 20°C and atmospheric pressure.
- activated particles refers to particles forming upon activation of the starting particles.
- activation is used to refer to a neutron capture event in a neutron- source such as a nuclear reactor.
- neutron capture refers to a nuclear reaction in which an atomic nucleus collides with a neutron, merges and forms a heavier nucleus, i.e. a different isotope.
- isotope refers to variants of a particular chemical element which differ in neutron number, but have the same proton number. Particular examples of isotopes referred to herein are 185 Re, 186 Re, 187 Re, and 188 Re.
- the term "irradiating" is used herein to refer to the process by which the starting particles according to the invention are exposed to a neutron flux.
- the thermal neutron flux density may vary.
- Neutrons can be provided by fission of uranium which initially supplies fast, i.e. high-energy neutrons. To obtain lower-energy thermal neutrons, the neutrons are slowed down by collision with the surrounding water.
- thermal neutrons refers to free neutrons with a kinetic energy smaller than 0.6 eV, i.e. about 0.025 eV.
- rhenium compound refers to a compound comprising rhenium.
- the specific composition of these compounds is not particularly limited as long as the particles comprising the rhenium compound are non-volatile and water-insoluble.
- the rhenium compounds according to the present invention may be rhenium sulfide, rhenium oxide or combinations thereof.
- the rhenium compound may be selected from a dirhenium heptasulfide, rhenium disulfide, a rhenium dioxide, rhenium trioxide, dirhenium heptaoxide, and combinations thereof.
- the rhenium compound of the invention may comprise or essentially consist of Re 187
- rhenium solution is used herein to refer to a fluid comprising rhenium, i.e. a solution such as an aqueous solution or a melt.
- a rhenium solution according to the invention may be a perrhenate solution.
- perrhenate refers to the metaperrhenate (Re0 4 ⁇ ) anion.
- a perrhenate solution can be obtained by converting metallic rhenium.
- metallic rhenium refers to elemental rhenium.
- Metallic rhenium can be converted to perrhenate solution by one of several ways.
- Metallic rhenium is stable below 1,000°C and atmospheric pressure. When fused with NaOH it forms a yellow melt from which Na 2 Re0 4 may be obtained. Alkali perrhenates can be melted without decomposition.
- rhenium material can be converted to soluble perrhenate by fusion with Na 2 0 2 . Fusion with Na 2 C0 3 or with Na 2 C0 3 + NaN0 3 is also possible and has the advantage that platinum crucibles can be used. NaN0 3 may be added if a stronger oxidizing environment is necessary. Further, sodium can also be replaced with potassium in the above mentioned compounds. However, it is the insight of the present inventor that there is a risk that some alkali metal residues will end up on the particles according to the invention, which may be activated during the neutron activation process.
- Stable 23 Na and 39 Kr41 K atoms can get activated to form undesirable 24 Na (strong gamma-emitters with a non- significant beta- emission) and 40 K/ 42 K (both beta-emitters with 42 K being a strong gamma-emitter).
- metallic rhenium can be converted to soluble perrhenate by reaction with hydrogen peroxide (H 2 0 2 ) under alkaline conditions (i.e. at a pH above 7). Conversion may be performed in an aqueous mixture of NaOH or NH 4 OH and H 2 0 2 .
- dissolved rhenium such as in form of perrhenate
- a suitable precipitating agent such as in form of perrhenate
- the perrhenate solution may be reconditioned and sulfide precipitation may be started.
- the source of sulfur may be dihydrogen sulfide (H 2 S) which may be gassed into the solution or may be produced in the solution from sources such as thioacetamide (CH 3 CSNH 2 ) or similar compounds.
- the precipitating agent of the invention for precipitating dissolved rhenium may be sulfide in form of thioacetamide.
- CH 3 CSNH 2 is hydrolyzed under strong acid conditions (i.e. at a pH below 2):
- the perrhenate anion Re0 4 ⁇ reacts with H 2 S to generate Re 2 S 7 .
- the term "average particle size" as used in context of the present invention refers to the central value of the particle size distribution of a certain sample.
- the size can be determined by several physical parameters known to the person skilled in the art, such as the mesh size of a sieve, the scattered light, the settling rate in a sedimentometer or by analysis of a microscopic image. Assuming a symmetric particle size distribution, the central value is representing not only the mean particle size, but also the median and the mode of the distribution.
- particle dimensions can be expressed by different parameters (e.g. diameter, aspect, surface, or volume). Consequently, there are also multiple definitions for the mean depending on the basis of the distribution calculation. For example, laser diffraction results are reported on a volume basis, so the volume mean can be used to define the central point of a particle size distribution, i.e. the average particle size.
- the volume mean can be calculated as shown in Formula (IV)
- the calculation can be interpreted by thinking of a histogram table showing the upper and lower limits of n size channels along with the percent within this channel.
- the D value for each channel is the geometric mean, i.e. the square root of upper x lower diameters.
- the geometric mean of each channel to the fourth power x the percent in that channel is summed over all channels.
- the geometric D to the third power x the percent in that channel is summed over all channels.
- median values are defined as the value where half of the population resides above this point, and half resides below this point.
- the volume-basis median value D50 is the size in micrometers that splits the particle size distribution with half above and half below this diameter.
- the mode is the peak of the frequency distribution, i.e. the particle size (or size range) most commonly found in the distribution.
- the average particle size of the particles according to the present invention may correspond to a D50 value of from 1 nanometer to 100 micrometers, such as a diameter of from 10 nanometers to 20 micrometers, from 20 nanometers to 10 micrometers, from 50 nanometers to 5 micrometers, or from 100 nanometers to 1 micrometer.
- particle size distribution refers to a mathematical function that defines the relative amount of particles present according to size. In addition to the location of the peak value(s) of this function, the width or breadth of the distribution is of particular relevance.
- a common approach to define the distribution width is to determine the D10, D50, and D90 values on the x-axis of the graph. While the D50 value, i.e. the median, corresponds to the diameter where half of the population lies below this value, the D90 and D10 values indicate the diameter below which 90% and 10% of the population lies, respectively.
- the particle size distribution D90 i.e. the diameter below which 90% of the particle sizes are located, may be in the range of 10% to 1,000% of the average particle size. That is to say that the D90 may be in the range of 0.1 x D50 and 10 x D50.
- the particle size distribution D90 is in the range of 25% to 400% of the average particle size, i.e. in the range of 0.25 x D50 and 4 x D50. More preferably, the particle size distribution D90 is in the range of 50% to 200% of the average particle size, i.e. in the range of 0.5 x D50 and 2 x D50.
- the term "homogeneously dispersed” as used herein refers to an emulsion in which the particles according to the present invention are in a continuous phase with a matrix component.
- matrix or matrix component refers to a carrier or a component of a carrier which is used as an auxiliary compound for taking up the activated particles according to the invention.
- resinous matrix is used to refer to a semi-fluid resin.
- % or percentage refers to wt or weight percentage unless otherwise indicated.
- a process of producing activated particles comprising 188 Re and/or 186 Re.
- the process comprises providing non-volatile and water-insoluble starting particles comprising a rhenium compound, and irradiating the particles with neutrons. During the irradiation, at least part of the 187 Re atoms undergo a neutron capture to form 188 Re and/or at least part of the 185 Reatoms undergo a neutron capture to form 186 Re, thereby forming said activated particles.
- the method of the present invention allows for the preparation of non-volatile and water-insoluble starting particles comprising a rhenium compound under non-radioactive conditions. Hence, compared to the conventional method radioactive contamination due to volatile or water-soluble compounds can be diminished. Additionally, the provided starting material can even be stored in-house without the need of radiation safety regulations. Only upon irradiation of the provided starting particles activation is accomplished leading to the radioactive source according to the invention.
- the step of providing said starting particles comprises providing a rhenium solution, optionally, mixing the rhenium solution with at least one additive, reacting the rhenium solution with a precipitating agent, thereby forming said rhenium compound, and precipitating said rhenium compound.
- the step further comprises isolating particles comprising the precipitated rhenium compound, and optionally may comprise washing and/or filtering and/or drying said particles.
- the term "isolating” as used in this context refers to separating the obtained particles.
- the particles comprising the precipitated rhenium compound may be isolated, for example, by centrifugation.
- the obtained pellet may then be subjected to a washing step, for example by re-suspension in an aqueous, saline or organic solution, and repeated centrifugation.
- filtering refers to a separation method.
- the isolated particles may be separated according to size using the sieving effect of a membrane with an appropriate mesh size.
- drying as used in this context refers to a step of removing any liquid supernatant of the obtained precipitate.
- the step of providing a rhenium solution comprises providing metallic rhenium, and reacting the metallic rhenium, thereby obtaining a perrhenate solution.
- the step of providing the starting particles may comprise dissolving metallic rhenium in nitric acid, thereby obtaining perrhenic acid.
- the step of providing the starting particles comprises converting metallic rhenium by fusion with one of NaOH, NaOH + NaN0 3 , Na 2 C0 3 , Na 2 C0 3 + NaN0 3 , Na 2 0 2 , KOH, KOH + KN0 3 , K 2 C0 3 , K 2 C0 3 + KN0 3 , K 2 0 2 , thereby obtaining alkali perrhenate.
- the step of providing the starting particles comprises reacting metallic rhenium using peroxide in alkaline conditions, thereby obtaining a perrhenate solution.
- peroxide is not particularly restricted, and as a typical example, hydrogen peroxide may be utilized.
- the step of providing said starting particles may comprise mixing the rhenium solution with one or more additives.
- the additive may be selected from polyvinylpyrrolidone (PVP), polyethylene glycol (PEG) and combinations thereof.
- the size of the provided starting particles can be adjusted by adding certain components.
- the inventors have observed that adding PVP and/or PEG helps to control the growth of crystals and hinders the growth of bigger crystals in favor of smaller ones.
- the distribution of the particle sizes can be unitized depending on the amount of additive mixed with the rhenium solution.
- the provided rhenium solution may be mixed with 1 to 50 wt PVP or
- the step of providing the starting particles further comprises determining the composition of the starting particles and/or the particle size distribution of the starting particles and/or the moisture content of the starting particles.
- composition of starting particles refers to the chemical composite of the particles such as the composition of rhenium compounds or the content of impurities. Particles size distributions are determined by methods well known in the art including laser diffraction, dynamic light scattering and image analysis.
- moisture content refers to the quantity of aqueous solution contained in a material, such as the isolated particles. Typical moisture contents of the starting particles are within a range of 0.1-5 wt%, based on the weight of the particles.
- the present invention enables an uncomplicated determination of quality parameters of the starting particles.
- the starting particles are not radioactive and thus the particle size, particle composition and the nature and amount of impurities can be easily controlled.
- the present invention allows to analyze the starting particles for the presence and amount of elements which might form during activation an isotope having an undesired half-life or emission spectrum. Further, if necessary, an undesirable charge may be disposed without logistic problems in terms of radioactive waste and thus with little loss of financial resources.
- the conservative method the amount of produced particles is relatively small and their radioactivity is high. Therefore, parameters such as the size and composition of the produced particles, and the nature and amount of impurities cannot be determined routinely.
- the present invention provides unexpected advantages in terms of quality analysis and therefore allows to obtain particles with desired properties.
- rhenium having an isotope distribution other than the natural isotope distribution may be used for preparing the starting particles.
- Rhenium enriched in 187 Re may be used as a starting material.
- Rhenium enriched in 187 Re can be purchased for instance from Traces Sciences International Corp.,
- the enrichment is 99.6% (i.e. comprising about 0.4% of 185 Re).
- activation of the starting particles will result in the production of 188 Re atoms.
- at least 65% of the rhenium atoms in the particles may be 187 Re and 188 Re.
- at least 80%, preferably at least 90%, more preferably at least 95% and even more preferably at least 99%, such as about 99.6% of the rhenium atoms in the particles may be 187 Re and 188 Re.
- rhenium enriched in 185 Re as well might be used as a starting material.
- rhenium enriched in 185 Re activation of the starting particles will result in the production of 186 Re atoms.
- at least 40%, in particular at least 60%, such as at least 80% of the rhenium atoms in the particles are 185 Re and 186 Re.
- the inventors have found that the risk of fluctuations in supply of radioactive material can be reduced by the present invention. Converting at least part of the 187 Re atoms to 188 Re atoms and/or at least part of the 185 Re atoms to 186 Re atoms each requires only one neutron capture event. Hence, irradiation can be performed with almost all research reactors and at only short irradiation times. Furthermore, short irradiation times mitigate the risk of activating atoms to form a long-lived isotope. Today, there are about 30 of such reactors only in Europe.
- the present invention provides for a cost efficient way of obtaining desired particles.
- the weight percentage of the rhenium compound in the particles is at least 60%, preferably at least 70%, more preferably at least 75%, for example at least 80%. Further, the weight percentage of the rhenium compound in the particles can be at least 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, 99.9% or more.
- the rhenium compound may be selected for example from a rhenium sulfide, a rhenium oxide, and combinations thereof.
- the rhenium compound may be selected from dirhenium heptasulfide, rhenium disulfide, rhenium dioxide, rhenium trioxide, dirhenium heptaoxide, and combinations thereof.
- the particles may comprise dirhenium heptasulfide in an amount of at least 50 wt%, optionally in combination with other rhenium compounds.
- the particles have a unimodal particle size distribution.
- the term "unimodal" as used herein refers to a particle size distribution possessing a unique mode only, i.e. one size range in which substantially all of the cumulative distribution of the particles is located.
- Figure 1 depicts a unimodal particle size distribution.
- the particles have an average particle size in the range of from 1 nanometer to 100 micrometers.
- the particles have an average particle size in the range of from 10 nanometers to 20 micrometers, from 20 nanometers to 10 micrometers, from 50 nm to 5 micrometers or from 100 nanometers to 1 micrometer.
- the particles have a particle size distribution D90 in the range of 10% to 1,000% of the average particle size.
- 90% of the particles typically fall within one order of magnitude below and one order of magnitude above the average size of the particles.
- 95% or even 99% or more of the particles fall within the range of 10 to 1,000% of the average particle size.
- at least 90% of the particles optionally fall within the range of 25 to 400% of the average particle size, such as within the range of 50 to 200% of the average particle size.
- the starting particles are typically irradiated with thermal neutrons.
- the starting particles may be activated at capsule irradiation with a thermal neutron flux density of about 10 14 neutrons/cm 2 /s.
- the process of the first aspect further comprises mixing the activated particles with a matrix component.
- the activated particles are homogeneously dispersed in the matrix component.
- the matrix component is not particularly limited, and any matrix components which are able to form a matrix upon drying, in particular a water-insoluble matrix, may be used.
- the matrix component may be a resinous matrix, preferably a water-based resinous matrix.
- a water-based paint might be employed as matrix component, for example an acrylic paint.
- the matrix component may comprise a particulate filler.
- the particulate filler may comprise one or more of at least one oxide, sulfide, carbonate, and in particular the filler may comprise Ti0 2 , A1 2 0 3 , Si0 2 , Fe 2 0 3 , or any combination thereof.
- the average particle size of the particles is at most 1,000% of the average particle size of the particulate filler.
- the average particle size of the particles may be at most 500% or at most 250% of the average particle size of the particulate filler.
- the average particle size of the particles may be at least 1%, at least 10% or at least 25% of the average particle size of the particulate filler. It is an insight of the inventors that, when a matrix containing particulate filler is used, the size of the activated particles and the size of the particulate filler advantageously are within similar size ranges (i.e. about 100%) in order achieve a homogenous dispersion of the activated particles within the matrix.
- the present invention provides a process of producing non-volatile and water-insoluble starting particles comprising a rhenium compound, which particles have an average particle size of from 1 nanometer to 100 micrometers.
- the process comprises providing a rhenium solution, optionally, mixing the rhenium solution with at least one additive, reacting the rhenium solution with a precipitating agent, thereby forming said rhenium compound, and precipitating said rhenium compound.
- the step further comprises isolating particles comprising the precipitated rhenium compound, and optionally may comprise washing and/or filtering and/or drying said particles.
- rhenium enriched in 187 Re or rhenium enriched in 185 Re may be used as a starting material.
- At least 65% of the rhenium atoms in the particles may be 187 Re.
- at least 80%, preferably at least 90%, more preferably at least 95% and even more preferably at least 99%, such as about 99.6% of the rhenium atoms in the particles are 187 Re.
- At least 40%, in particular at least 60%, such as at least 80% of the rhenium atoms in the particles may be 185 Re.
- an activated particle wherein said particle is obtainable by the process according to the first aspect of the invention.
- a starting particle wherein said particle is obtainable by the processes according to the second aspect of the invention.
- the present invention provides a non-volatile and water- insoluble activated particle comprising a rhenium compound and 188 Re atoms, wherein a ratio of 188 W atoms to 188 Re atoms in said activated particle is less than 50 ppm.
- ratio is used to refer to the quantitative relationship between 188 W atoms and 188 Re atoms, i.e. the number of 188 W atoms contained in the particles per one million 188 Re atoms.
- the non-volatile and water-insoluble activated particles are substantially free of 188 W atoms.
- 188 W impurities entail a significant risk in terms of radiation protection due to the comparably long half-life of 188 W (about 70 days).
- 188 W impurities can only be detected after several half-lives of 188 Re (i.e. several times the half-life of about 17 hours). This results in either loosing radioactivity during the time of waiting until the composition of the 1 1 8 0 8 0 W/ 1 1 8 0 8 0 Re generator eluate can be determined or the use of material with an unknown degree of 188 W impurities that may result in waste management problems.
- At least 65% of the rhenium atoms are 187 Re and 188 Re.
- at least 80%, preferably at least 90%, more preferably at least 95% and even more preferably at least 99%, such as about 99.6% of the rhenium atoms may be 1 1 8 0 7 , Re and 1 1 8 0 8 0 Re.
- a non-volatile and water- insoluble activated particle comprising a rhenium compound and 186 Re.
- at least 40%, in particular at least 60%, such as at least 80% of the rhenium atoms are 185 Re and 186 Re.
- the particles have directly after activation an activity of 1-600 GBq per 10 mg rhenium, preferably an activity of 2-50 GBq per 10 mg rhenium.
- directly after activation means the radioactivity value as determined in a control sample within 10 minutes following activation in the neutron source, or as extrapolated to that time point.
- the activation of the particles is desirably controlled to provide a defined activity for the intended use.
- the intended use is epidermal radionuclide therapy
- the activation is preferably controlled to provide an activity at the time of the treatment within the range of from 25-400 MBq per cm of skin region to be treated, in particular within the range of from 50-150 MBq per cm of skin region to be treated.
- the activation takes into account the estimated time span between activation and actual use.
- the required activation time may be calculated. This calculation typically includes an estimated amount for the process loss and losses due to radioactive decays.
- the formula describing the radioactivity A produced by neutron activation is given by:
- N is the amount of atoms of the irradiated isotope
- ⁇ is the cross section of the irradiated isotope
- T is the half-life of the daughter isotope
- tj rr is the irradiation time, with T and V being in the same time unit.
- N can be calculated from Formula (VI) with the mass m in g of the irradiated isotope and its atomic weight w in g/mol.
- the present invention provides a non-volatile and water-insoluble isolated starting particle comprising a rhenium compound, the particle having a particle size in the range of 1 nanometer to 100 micrometers.
- the particles have an average particle size in the range of from 10 nanometers to 20 micrometers, from 20 nanometers to 10 micrometers, or from 50 nm to 5 micrometers.
- the rhenium compound of the particles may be derived from rhenium having an isotope distribution other than the natural isotope distribution.
- the rhenium compound of the particles may be derived from rhenium enriched in 187 Re.
- at least 65% of the rhenium atoms may be 187 Re.
- at least 80%, preferably at least 90%, more preferably at least 95% and even more preferably at least 99%, such as about 99.6% of the rhenium atoms may be 1 1 8 0 7 , Re.
- the rhenium compound of the particles according to the seventh aspect of the present invention may be derived from enriched in 185 Re. According to such embodiment, at least 40%, in particular at least 60%, such as at least 80% of the rhenium atoms may be 185 Re.
- the invention provides a specific embodiment, wherein the weight percentage of the rhenium compound in the particles according to one of the fifth, sixth or seventh aspect is at least 60%, preferably at least 70%, more preferably at least 75%, for example at least 80%.
- the particle of any of the fifth, sixth and seventh aspect further may comprise at least one additive such as polyvinylpyrrolidone (PVP), polyethylene glycol (PEG) and combinations thereof.
- the particles may comprise 1 to 50 wt% polyvinylpyrrolidone (PVP) or polyethylene glycol (PEG), based on the weight of rhenium.
- PVP polyvinylpyrrolidone
- PEG polyethylene glycol
- the particles may comprise 0.01 to 0.5 mg PVP, such as 0.05 to 0.3 mg PVP per 1 mg of the rhenium compound.
- the rhenium compound of the particle of any of the fifth, sixth and seventh aspect may be selected from a rhenium sulfide, a rhenium oxide, and combinations thereof.
- the rhenium compound may be selected from dirhenium heptasulfide, rhenium disulfide, rhenium dioxide, rhenium trioxide, dirhenium heptaoxide, and combinations thereof.
- the particles may comprise dirhenium heptasulfide in an amount of at least 50 wt%, optionally in combination with other rhenium compounds.
- the particles have an average particle size in the range of from 1 nanometer to 100 micrometers. Further details with respect to average particle size and particle size distribution of the plurality of particles are as discussed above, in particular as discussed above in the context of the process according to the first aspect of the present invention.
- the present invention provides a composition comprising a plurality of activated particles according to the eighth aspect and a carrier. Further details with respect to the carrier, matrix component of the carrier, particulate filler, and distribution of the plurality of activated particles in the carrier are as discussed above, in particular as discussed above in the context of the process according to the first aspect of the present invention.
- the average particle size of the activated particles is at most 1,000% of the average particle size of the particulate filler.
- the average particle size of the activated particles may be at most 500%, or at most 250% of the average particle size of the particulate filler.
- the average particle size of the particles may be for example at least 0.1%, at least 1%, at least 10% or at least 25% of the average particle size of the particulate filler.
- the present invention contemplates using the activated particles, and in particular the composition according to the present invention in radionuclide therapy.
- the present invention contemplates using the activated particles, and in particular the composition according to the present invention in epidermal radionuclide therapy.
- epidermal radionuclide therapy refers to a special type of brachytherapy, i.e. radiotherapy where the radiation source is placed onto or adjacent to the outer skin at the area requiring treatment.
- the activated particles or the composition, respectively, according to the present invention may be used in a method of treatment of a skin lesion, which might be a cancerous or non-cancerous skin lesion.
- skin lesions which may be treated with the activated particles or the composition according to the present invention include basal cell carcinoma (BCC), squamous cell carcinoma (SCC), actinic keratosis, keloid, Bowen's disease (Morbus Bowen), extramammary Paget's disease (Morbus Paget), Queyrat's disease (Morbus Queyrat), cutaneous lymphoma, lentigo maligna, and lentigo maligna melanoma.
- BCC basal cell carcinoma
- SCC squamous cell carcinoma
- actinic keratosis keloid
- Bowen's disease Moorbus Bowen
- Extramammary Paget's disease Moorbus Paget
- Queyrat's disease Morbus Queyrat
- the present invention contemplates using the activated particles, and in particular the composition according to the present invention in cosmetic applications.
- One cosmetic application presently contemplated in particular relates to removing or desaturating a tattoo in a skin region.
- Another cosmetic application presently contemplated in particular relates to treating scar tissue or removing scars.
- the present invention also provides a method comprising applying a plurality of activated particles or the composition according to the present invention to a skin region of a subject in order to desaturate a tattoo in a skin region or treat scar tissue.
- NH 4 187 Re0 4 (about 10 mg) is mixed with 2.5 g thioacetamide, 3 mg PVP and 1 milliliter concentrated HC1 and heated at 90°C for 30 minutes. The particles are precipitated by centrifugation and the precipitate is separated from other residuals of the chemical reaction, as well as components that did not react (e.g. thioacetamide).
- Starting particles comprising
- the starting particles obtained as described above (about 10 mg, based on the weight of rhenium) are irradiated at a neutron flux of 10 14 neutrons/cm 2 /s for 1 hour.
- the irradiation produced a radioactivity of 9 GBq.
- Carrier-free 188 Re (as perrhenate) is obtained from a 188 W/ 188 Re generator by elution with saline.
- the solution (about 3 mg NH 4 188 Re0 4 per 10 ml) is processed to 188 Re 2 S7 by adding thioacetamide and concentrated HCl as well as heating (90°C for 30 minutes).
- the particle size distribution is analyzed, of a sample which has been stored until the radioactivity had decayed sufficiently. The obtained distribution is shown in Figure 2. At least two different peaks can be distinguished, suggesting an at least bimodal particle size distribution.
- a process of producing activated particles comprising 188 Re and/or 186 Re comprising: a) providing non- volatile and water-insoluble starting particles comprising a rhenium compound,
- step i) comprises:
- step of providing the starting particles comprises reacting metallic rhenium using peroxide in alkaline conditions, thereby obtaining a perrhenate solution.
- step of providing the starting particles comprises mixing a rhenium solution with at least one additive, in particular wherein the additive is selected from polyvinylpyrrolidone (PVP), polyethylene glycol (PEG) and combinations thereof.
- the additive is selected from polyvinylpyrrolidone (PVP), polyethylene glycol (PEG) and combinations thereof.
- step of providing the starting particles further comprises determining the composition of the starting particles and/or the particle size distribution of the starting particles and/or the moisture content of the starting particles.
- 99.6% of the rhenium atoms in the particles are 1 1 8 0 7 , Re and 1 1 8 0 8 0 Re.
- the weight percentage of the rhenium compound in the particles is at least 60%, preferably at least 70%, more preferably at least 75%, for example at least 80%.
- rhenium compound is selected from a rhenium sulfide, a rhenium oxide, and combinations thereof.
- the matrix component is a resinous matrix, preferably a water-based resinous matrix and more preferably a water-based paint, for example an acrylic paint.
- the particulate filler comprises at least one oxide, sulfide, carbonate, or a combination thereof, in particular wherein the filler comprises for example Ti0 2 , A1 2 0 3 , Si0 2 and/or Fe 2 0 3 .
- step i) comprises:
- step i) comprises reacting metallic rhenium using peroxide in alkaline conditions, thereby obtaining a perrhenate solution.
- step ii) the rhenium solution is mixed with at least one additive, in particular wherein the additive is selected from polyvinylpyrrolidone (PVP), polyethylene glycol (PEG) and combinations thereof.
- PVP polyvinylpyrrolidone
- PEG polyethylene glycol
- a non-volatile and water-insoluble activated particle comprising a rhenium compound and 188 Re atoms, wherein a ratio of 188 W atoms to 188 Re atoms in said activated particle is less than 50 ppm.
- a non-volatile and water-insoluble isolated starting particle comprising a rhenium compound, the particle having a particle size in the range of from 1 nanometer to 100 micrometers.
- a composition comprising a plurality of activated particles of any of clauses 51 to 54 and a carrier.
- composition of clause 59 wherein the particulate filler comprises at least one oxide, sulfide, carbonate, or a combination thereof, in particular wherein the filler comprises for example Ti0 2 , A1 2 0 3 , Si0 2 and/or Fe 2 0 3 .
- composition or plurality particles for use of clause 62 or 63 in the treatment of a skin lesion preferably wherein the skin lesion is a cancerous or non-cancerous lesion, in particular wherein the skin lesion is selected from the group consisting of a basal cell carcinoma (BCC), a squamous cell carcinoma (SCC), an actinic keratosis, a keloid, Bowen's disease, extramammary Paget's disease, Queyrat's disease, cutaneous lymphoma, lentigo maligna, lentigo maligna melanoma.
- BCC basal cell carcinoma
- SCC squamous cell carcinoma
- an actinic keratosis a keloid
- Bowen's disease extramammary Paget's disease
- Queyrat's disease cutaneous lymphoma
- lentigo maligna lentigo maligna melanoma.
- a method of desaturating a tattoo in a skin region or removing scars comprising applying the composition of any of clauses 55 to 61 or the plurality of activated particles of any of clauses 51 to 54 to the skin region.
Abstract
Description
Claims
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PL17788168T PL3523811T3 (en) | 2016-10-10 | 2017-10-10 | Production of re-188/186 particles |
US16/340,450 US11135323B2 (en) | 2016-10-10 | 2017-10-10 | Production of Re-188/186 particles |
KR1020197013393A KR102488513B1 (en) | 2016-10-10 | 2017-10-10 | Production of RE-188/186 particles |
NZ752287A NZ752287A (en) | 2016-10-10 | 2017-10-10 | Production of re-188/186 particles |
RU2019113502A RU2749141C2 (en) | 2016-10-10 | 2017-10-10 | OBTAINING Re-188/186 PARTICLES |
AU2017343616A AU2017343616B2 (en) | 2016-10-10 | 2017-10-10 | Production of Re-188/186 particles |
CN201780062421.9A CN110168669B (en) | 2016-10-10 | 2017-10-10 | Preparation of RE-188/186 particles |
CA3039834A CA3039834A1 (en) | 2016-10-10 | 2017-10-10 | Production of re-188/186 particles |
IL265932A IL265932B (en) | 2016-10-10 | 2019-04-09 | Production of re-188/186 particles |
CONC2019/0004738A CO2019004738A2 (en) | 2016-10-10 | 2019-05-08 | Particle production re-188/186 |
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EP (1) | EP3523811B1 (en) |
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EP3854757A1 (en) | 2020-01-23 | 2021-07-28 | Technische Universität München | Rhenium sulfide particles and microwave assisted process for their preparation |
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EP3854757A1 (en) | 2020-01-23 | 2021-07-28 | Technische Universität München | Rhenium sulfide particles and microwave assisted process for their preparation |
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CL2019000951A1 (en) | 2019-09-27 |
RU2749141C2 (en) | 2021-06-07 |
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KR20190058645A (en) | 2019-05-29 |
NZ752287A (en) | 2023-07-28 |
AU2017343616A1 (en) | 2019-05-16 |
IL265932A (en) | 2019-05-30 |
PL3523811T3 (en) | 2021-10-11 |
US20190290789A1 (en) | 2019-09-26 |
EP3523811B1 (en) | 2021-04-14 |
CA3039834A1 (en) | 2018-04-19 |
KR102488513B1 (en) | 2023-01-12 |
EP3523811A1 (en) | 2019-08-14 |
CO2019004738A2 (en) | 2019-05-21 |
US11135323B2 (en) | 2021-10-05 |
BR112019007308A2 (en) | 2019-07-02 |
DE102016119239A1 (en) | 2018-04-12 |
RU2019113502A (en) | 2020-11-13 |
RU2019113502A3 (en) | 2020-11-13 |
CN110168669B (en) | 2023-10-27 |
IL265932B (en) | 2022-04-01 |
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