WO2018006383A1 - Appareil d'ablation par décharge entre électrodes - Google Patents

Appareil d'ablation par décharge entre électrodes Download PDF

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Publication number
WO2018006383A1
WO2018006383A1 PCT/CN2016/089276 CN2016089276W WO2018006383A1 WO 2018006383 A1 WO2018006383 A1 WO 2018006383A1 CN 2016089276 W CN2016089276 W CN 2016089276W WO 2018006383 A1 WO2018006383 A1 WO 2018006383A1
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WO
WIPO (PCT)
Prior art keywords
ablation
electrode
electrodes
tube body
tissue
Prior art date
Application number
PCT/CN2016/089276
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English (en)
Chinese (zh)
Inventor
李楚武
邹波
朱晓林
Original Assignee
四川锦江电子科技有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 四川锦江电子科技有限公司 filed Critical 四川锦江电子科技有限公司
Priority to PCT/CN2016/089276 priority Critical patent/WO2018006383A1/fr
Publication of WO2018006383A1 publication Critical patent/WO2018006383A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves

Definitions

  • the invention relates to the field of ablation, in particular to an ablation device for interelectrode discharge.
  • the human body is a complex structure composed of many organic and inorganic substances.
  • the body fluid contains a large amount of dielectric materials, such as ions, water, colloidal particles, etc., and the human body mainly relies on ions to conduct current.
  • dielectric materials such as ions, water, colloidal particles, etc.
  • the human body mainly relies on ions to conduct current.
  • the direction of concentration change of ions changes with positive and negative half-cycles in the direction of current.
  • the ions between the two electrodes move rapidly in the direction of the power line, and gradually change from the moving state to the vibrating state. Due to the different sizes, masses, charges and moving speeds of various ions, the ions rub against each other and collide with other particles to produce biothermal action.
  • Radio frequency refers to the radio frequency, but it does not belong to the division of the band in radio communication, because the radiation performance is very low in such a frequency range, so it is rarely used in communication equipment.
  • the main effect on the human body is the thermal effect, when the radio frequency current When the frequency is high to a certain value, it will cause the charged ions in the tissue to move and heat up, causing the water inside and outside the tissue to evaporate, dry, shrink and fall off to cause aseptic necrosis.
  • Radiofrequency ablation is the use of high-frequency radio frequency current to locally heat up the body's lesion tissue, from the aseptic necrosis of the lesion tissue, thus achieving the purpose of treatment.
  • radiofrequency ablation is used in the treatment of a variety of diseases, such as arrhythmias, various types of cancer, disc herniation, and RFA thyroid.
  • Commonly used devices are mainly radio frequency devices, back plates and catheter-containing catheters (or electrode pins) that contact the body tissue to be ablated, the back plate is attached to the back of the human body, and the ablation catheter containing the electrodes contacts the body to be ablated.
  • the tissue, the back plate is connected to one electrode of the RF device, and the electrode on the ablation catheter is connected to the other electrode of the RF device. If the RF device is working, it will be in the RF device, the back plate, the body tissue and the ablation catheter (or electrode)
  • the needle forms a closed current loop.
  • the current density of the human tissue in contact with the back plate is much smaller than that of the ablation catheter electrode.
  • the commonly used technology is that the head electrode discharges to the back plate. Because the back plate is attached to the human skin tissue, the tissue to be ablated is inside the human body, and the whole body is energized by ablation with radio frequency current, especially the ablation catheter and Human tissue between the current paths of the back plates also has an increased temperature and a higher risk of damaging normal tissue.
  • the object of the present invention is to overcome the above-mentioned deficiencies in the prior art and to provide an ablation device for making ablation treatment more targeted and controllable, and reducing the inter-electrode discharge to the human body.
  • the present invention provides the following technical solutions:
  • An inter-electrode discharge ablation device for ablating a lesion tissue in a human body including a tube body, a distal end of the tube body being a distal tube body having an electrode for ablation disposed thereon, the electrode including a positive electrode a negative electrode, the positive electrode and the negative electrode are separately disposed, and the relative positions of the positive electrode and the negative electrode are set to be capable of simultaneously contacting a lesion tissue.
  • the ablation of the lesion tissue is ablated by the electrode plus the back plate, and the back plate needs to be in contact with the human body, usually attached to the skin, and then the electrode is inserted into the human body to contact the lesion tissue.
  • the electrode-body-back plate forms a current between the plates, generates RF energy
  • this ablation method is more complicated, and because the current needs to pass through the whole body, it will also cause certain other healthy tissues.
  • the destruction increase the burden on the patient, and even bring sickness;
  • a separate positive electrode and a negative electrode are simultaneously disposed on the distal tube body, and the positive electrode and the negative electrode are mutually discharged, and high RF energy is generated in the middle, and the RF energy is used for tissue ablation and ablation.
  • the treatment is more targeted and controllable, and there is no longer a need for current to flow through the entire body as in the prior art, causing damage to the positive electrode-disease tissue-negative electrode to form RF energy, compared to existing Technology reduces the damage to the human body during the ablation process.
  • two conductive members that apply current to the human tissue are disposed on the ablation catheter, and the area of the human body through which the current passes is small, and it is easy to accurately determine the specific location of the lesion tissue, thereby inducing disease and helping to find the lesion tissue. More accurate and rapid determination of the location of the lesion tissue can save the ablation operation time and improve the ablation efficiency, thereby reducing the patient's pain and reducing the risk of surgery.
  • the cooling effect is not good.
  • the temperature at which the human tissue and the conductive member are attached is higher than other parts. If the ablative solution is used to cool the ablated human tissue, the ablation temperature may be too high, and the ablation depth may be too deep, even piercing the human tissue. Cause a medical accident.
  • at least one of the conductive members is provided with a solution hole communicating with the solution chamber, so that the ablation liquid can be transmitted to the body tissue of a predetermined ablation through the solution chamber and the solution hole, so that the ablation liquid can be cooled and adhered to the conductive member.
  • the cooling effect is better, the ablation temperature is easier to control, and the smile effect is better.
  • a conductive member is disposed at a center of an end surface of the end portion of the ablation catheter that protrudes into the body tissue, that is, the projection of the tube body is a circle on a projection surface perpendicular to the axis of the tube body.
  • a conductive member is disposed at a center of the tube projection.
  • the conductive member is provided with the solution hole, and the conductive members are insulated from each other.
  • the positive electrode and the negative electrode are both disposed at the distal end of the distal tube body, and are disposed at the end portion, which is more targeted to the lesion tissue.
  • an insulating member is disposed between the positive electrode and the negative electrode, and the positive electrode and the negative electrode are absolutely isolated by an insulating member, so that the positive electrode and the negative electrode have better isolation effect, and the positive electrode and the positive electrode are The negative electrodes are facing each other and discharge high RF energy in the middle.
  • the RF energy is used for tissue ablation.
  • the ablation effect is better than the use of insulating members (although positive and negative electrodes can be achieved without contact). insulation).
  • the distal tube body is internally provided with a perfusion tube capable of perfusion liquid, which communicates with the surface of the distal tube body for infusing liquid during cooling ablation to cool the tissue surface to obtain higher Ablation depth.
  • the outer wall of the insulating member is provided with a filling hole communicating with the pouring tube.
  • a temperature sensor is disposed under the positive electrode and the negative electrode for timely measuring the surface temperature of the tissue to provide a safety guarantee for the doctor during treatment, and to avoid damage to the healthy tissue of the patient due to excessive temperature.
  • the temperature sensor is soldered in the positive electrode and the negative electrode to directly measure the temperature of the electrode, and the manufacturing process is more difficult, but the temperature is compared to the way of being disposed below.
  • the degree of detection is more accurate, making the ablation process safer.
  • the distal end of the distal tube body is provided with a pressure sensor capable of measuring the pressure from the tissue, and the positive electrode and the negative electrode are deformed after contacting the tissue (the elastic force of the tissue is opposite to the electrode The resulting reverse thrust), which causes the pressure sensor at the back end to deform as well, allowing the pressure sensor to detect pressure and provide a scientific basis for the doctor to improve the safety and reliability of the ablation treatment.
  • the electrodes are capable of delivering a radio frequency current that is capable of stimulating the lesion for inducing a disease.
  • the preferred solution stimulates human tissue by electric shock to induce disease to assist in finding the position of the tissue site that needs to be ablated, that is, when determining the position of the predetermined ablation tissue by using the prior art, the steps of the present scheme are used to assist the body tissue.
  • the two conductive members that apply current are disposed on the ablation catheter.
  • the area of the human body through which the current passes is small, and it is easy to accurately determine the specific location of the lesion tissue. Therefore, the disease can be induced and the lesion tissue can be searched for, and the lesion tissue can be more accurately and quickly determined.
  • the position can save the ablation operation time and improve the ablation efficiency, thereby reducing the patient's pain and reducing the risk of surgery.
  • the electrode can be used as a mapping electrode to mark the position of the tip end of the electrode.
  • the present invention also provides a method for performing superficial ablation using the ablation device described above, comprising the steps of:
  • the electrode of the distal tube reaches the vicinity of the lesion tissue, and the electrodes are stimulated to induce disease.
  • the stimulation is induced between the electrodes of the distal tube body to induce disease, and if the abnormality electrical signal cannot be detected by the mapping electrode, it is determined that the ablation is successful.
  • the invention further provides a method for performing deep ablation using the ablation device described above, comprising the steps of:
  • the electrode of the distal tube reaches the vicinity of the lesion tissue, and the electrodes are stimulated to induce disease.
  • the stimulation is induced between the distal electrodes of the catheter, and the disease is induced. If the abnormality is not detected by the mapping electrode, it is determined that the ablation is successful.
  • Figure 1 is a schematic view of ablation of the present invention
  • Figure 3 is a cross-sectional view of the present invention.
  • Figure 4 is a partial cross-sectional view of the present invention.
  • Figure 5 is a cross-sectional view of the main tube
  • Figure 6 shows the overall schematic of the device
  • an inter-electrode discharge ablation device is used for ablating a lesion tissue in a human body (as shown in FIG. 1, the shaded portion is a human tissue 6, that is, a lesion tissue requiring ablation), including a tube body, A segment of the distal end of the tubular body is a distal tubular body 4 on which an electrode for ablation is disposed. As shown in FIG. 1, the shaded portion is a human tissue 6, that is, a lesion tissue requiring ablation), including a tube body, A segment of the distal end of the tubular body is a distal tubular body 4 on which an electrode for ablation is disposed. As shown in FIG. 1, the shaded portion is a human tissue 6, that is, a lesion tissue requiring ablation), including a tube body, A segment of the distal end of the tubular body is a distal tubular body 4 on which an electrode for ablation is disposed. As shown in FIG. 1, the shaded portion is a human tissue 6, that is, a lesion tissue
  • the electrode includes a positive electrode 1 and a negative electrode 2, and the positive electrode 1 and the negative electrode 2 are disposed at The distal end of the distal tube body 4, the positive electrode 1 and the negative electrode 2 are separately disposed, and the insulating member 3 is disposed between the positive electrode 1 and the negative electrode 2 (for plastic materials, if there is good biocompatibility Polycarbonate, etc., the positive electrode 1, the negative electrode 2
  • the relative position is set to be able to simultaneously contact a lesion tissue, and the positive electrode 1 and the negative electrode 2 are respectively connected with a positive electrode lead 8 and a negative electrode lead 9 for energizing the electrode, transmitting radio frequency energy, and a positive electrode.
  • the wire 8 and the negative electrode wire 9 are disposed inside the distal tube body 4 and arranged along the tube body, and finally connected to the power source.
  • the positive electrode 1 and the negative electrode 2 are symmetrically disposed at the distal end of the distal tube body 4. The head.
  • the distal tube body 4 is internally provided with a perfusion tube 7 capable of perfusion liquid, which communicates with the surface of the distal tube body 4.
  • the outer wall of the insulating member 3 is provided with a communication with the perfusion tube 7.
  • the positive electrode 1 and the negative electrode 2 are better contacted to the tissue, and the perfusion hole 31 located between the two electrodes flows out of the liquid, so that the tissue surrounding the electrode can be better cooled.
  • the end of the distal tube 4 is provided with a groove, and the positive electrode 1 and the negative electrode 2 are provided with protrusions that cooperate with the grooves, and the positive electrode 1 and the negative electrode 2 pass through the protrusions.
  • a temperature sensor 10 is mounted at the end of the distal tube body 4, under the positive electrode 1 and the negative electrode 2, which is soldered in the positive electrode 1 and the negative electrode 2.
  • the temperature sensor 10 is 2 thermoelectrics.
  • the even lead wire is welded, and the positive electrode lead 8 and the negative electrode lead 9 are connected from the distal tube body 4 through the groove to the positive electrode 1 and the negative electrode 2. This structure is more convenient to install and is easier to process. .
  • the rear end of the distal tube body 4 is provided with a pressure sensor 11 capable of measuring pressure from the tissue
  • the pressure sensor 11 may be a piezoresistive sensor or a piezoelectric sensor, and the pressure sensor 11 is not Limited to the manner in the embodiments of the present patent, the pressure sensor 11 may further include a pressure sensor 11 that is tested using magnetic, optical, and ultrasonic waves.
  • the luer connector 15 is connected to the perfusion tube 8 for delivering a channel for perfusion of liquid.
  • Connector 16 for use with Be prepared to connect.
  • Embodiments of the present invention may also provide an ablation device that uses a radio frequency current between the electrodes to stimulate a lesion to induce a disease using the emitted radio frequency current.
  • the user can adjust the magnitude and period of the RF current according to experience or predetermined settings to induce lesions that may be present.
  • An embodiment of the present invention a method for performing superficial ablation using the ablation device described above, comprising the steps of:
  • the electrode of the distal tube reaches the vicinity of the lesion tissue, and the electrodes are stimulated to induce disease.
  • the stimulation is induced between the electrodes of the distal tube body to induce disease, and if the abnormality electrical signal cannot be detected by the mapping electrode, it is determined that the ablation is successful.
  • the present invention further provides a method for deep ablation using the backing plate of the above ablation device, comprising the following steps:
  • the electrode of the distal tube reaches the vicinity of the lesion tissue, and the electrodes are stimulated to induce disease.
  • the stimulation is induced between the distal electrodes of the catheter, and the disease is induced. If the abnormality is not detected by the mapping electrode, it is determined that the ablation is successful.

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Electromagnetism (AREA)
  • Engineering & Computer Science (AREA)
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Abstract

L'invention porte sur un appareil d'ablation par décharge entre électrodes pour l'ablation d'un tissu de lésion (6) dans un corps humain. L'appareil d'ablation comprend un corps de tube, dont une section à son extrémité distale est un corps de tube d'extrémité distale (4), des électrodes (1, 2) pour l'ablation étant disposées dessus. Les électrodes (1, 2) sont disposées séparément, la paire d'électrodes (1, 2) est disposée à des positions relatives, de sorte qu'elles entrent simultanément en contact avec le tissu de la lésion (6), et les électrodes (1, 2) ont une fonction de cartographie et stimulent leur libération mutuelle pour trouver le site de la lésion. L'appareil d'ablation par décharge entre électrodes permet au traitement d'ablation d'être plus ciblé et contrôlable, et réduit les dommages faits au corps humain.
PCT/CN2016/089276 2016-07-07 2016-07-07 Appareil d'ablation par décharge entre électrodes WO2018006383A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/CN2016/089276 WO2018006383A1 (fr) 2016-07-07 2016-07-07 Appareil d'ablation par décharge entre électrodes

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Application Number Priority Date Filing Date Title
PCT/CN2016/089276 WO2018006383A1 (fr) 2016-07-07 2016-07-07 Appareil d'ablation par décharge entre électrodes

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WO2018006383A1 true WO2018006383A1 (fr) 2018-01-11

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115252114A (zh) * 2022-07-25 2022-11-01 江苏邦士医疗科技有限公司 一种鼻甲止血电极

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6117131A (en) * 1995-06-09 2000-09-12 Engineering & Research Associates, Inc. Multi-electrode probe for thermal ablation
CN103584853A (zh) * 2012-08-17 2014-02-19 麦德托尼克消融前沿有限公司 单相动作电位的标测导管的制造方法
US20140073893A1 (en) * 2012-09-12 2014-03-13 Boston Scientific Scimed Inc. Open irrigated-mapping linear ablation catheter
CN203493737U (zh) * 2013-10-15 2014-03-26 上海微创电生理医疗科技有限公司 一种医疗导管和射频治疗***
CN104010585A (zh) * 2011-10-26 2014-08-27 麦德托尼克消融前沿有限公司 半圆形肺静脉消融导管
CN104799937A (zh) * 2014-01-27 2015-07-29 深圳市信立泰生物医疗工程有限公司 一种肾神经消融导管及其应用
CN105078569A (zh) * 2014-05-22 2015-11-25 南京医科大学第一附属医院 交感神经标测消融装置及***
CN106308929A (zh) * 2015-06-30 2017-01-11 四川锦江电子科技有限公司 一种极间放电的消融装置
CN106308928A (zh) * 2015-06-30 2017-01-11 四川锦江电子科技有限公司 一种具有标测功能的消融装置

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6117131A (en) * 1995-06-09 2000-09-12 Engineering & Research Associates, Inc. Multi-electrode probe for thermal ablation
CN104010585A (zh) * 2011-10-26 2014-08-27 麦德托尼克消融前沿有限公司 半圆形肺静脉消融导管
CN103584853A (zh) * 2012-08-17 2014-02-19 麦德托尼克消融前沿有限公司 单相动作电位的标测导管的制造方法
US20140073893A1 (en) * 2012-09-12 2014-03-13 Boston Scientific Scimed Inc. Open irrigated-mapping linear ablation catheter
CN203493737U (zh) * 2013-10-15 2014-03-26 上海微创电生理医疗科技有限公司 一种医疗导管和射频治疗***
CN104799937A (zh) * 2014-01-27 2015-07-29 深圳市信立泰生物医疗工程有限公司 一种肾神经消融导管及其应用
CN105078569A (zh) * 2014-05-22 2015-11-25 南京医科大学第一附属医院 交感神经标测消融装置及***
CN106308929A (zh) * 2015-06-30 2017-01-11 四川锦江电子科技有限公司 一种极间放电的消融装置
CN106308928A (zh) * 2015-06-30 2017-01-11 四川锦江电子科技有限公司 一种具有标测功能的消融装置

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115252114A (zh) * 2022-07-25 2022-11-01 江苏邦士医疗科技有限公司 一种鼻甲止血电极
CN115252114B (zh) * 2022-07-25 2023-08-25 邦士医疗科技股份有限公司 一种鼻甲止血电极

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