WO2017135658A1 - Système et procédé de détection de plaque - Google Patents

Système et procédé de détection de plaque Download PDF

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Publication number
WO2017135658A1
WO2017135658A1 PCT/KR2017/001045 KR2017001045W WO2017135658A1 WO 2017135658 A1 WO2017135658 A1 WO 2017135658A1 KR 2017001045 W KR2017001045 W KR 2017001045W WO 2017135658 A1 WO2017135658 A1 WO 2017135658A1
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WO
WIPO (PCT)
Prior art keywords
image
thrombus
photoacoustic
laser
detection system
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PCT/KR2017/001045
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English (en)
Korean (ko)
Inventor
송철규
신동호
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전북대학교산학협력단
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Publication of WO2017135658A1 publication Critical patent/WO2017135658A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings

Definitions

  • the present invention relates to thrombus detection techniques, and more particularly to systems and methods for detecting thrombus generated in blood vessels.
  • Plaque formed in the blood vessels causes blood vessel occlusion, leading to serious conditions such as acute myocardial infarction, especially in the case of carotid artery can cause stroke, cerebral infarction, etc., the early detection of carotid artery thrombus is more urgent.
  • the present invention has been made to solve the above problems, an object of the present invention, to provide a method for detecting carotid artery thrombosis, to provide a thrombus detection system and method combining the ultrasound image and the photoacoustic image.
  • Another object of the present invention is to provide a thrombus detection system and method using a transesophageal probe in which ultrasound and a laser are integrated.
  • the thrombus detection system the laser generating a laser pulse to irradiate the blood vessels; A sensor for detecting photoacoustic light emitted from the blood vessel irradiated with the laser pulse; An optoacoustic generator configured to generate an optoacoustic image by using the detection result of the sensor; An ultrasound image generator configured to generate an ultrasound image of the blood vessel; And an extractor which extracts a blood clot using the photoacoustic image and the ultrasound image.
  • the extractor may extract the thrombus from the difference image between the photoacoustic image and the ultrasound image.
  • the thrombus detection system may further include a combination unit for combining the photoacoustic image and the ultrasound image.
  • the thrombus detection system may further include a display for displaying the combination result by the combination unit and the extraction result by the extraction unit.
  • the laser pulse may be a laser pulse of the wavelength of the largest thermal expansion of the main component of the thrombus.
  • the laser pulse may be a laser pulse having a wavelength of 1210 nm.
  • the laser generating a laser pulse to irradiate the blood vessels;
  • An ultrasonic generator for outputting ultrasonic waves to the blood vessels;
  • a sensor for detecting the photoacoustic light emitted from the blood vessel irradiated with the laser pulse, and for sensing the ultrasonic wave reflected from the blood vessel irradiated by the ultrasonic generator;
  • An image generator configured to generate a photoacoustic image and an ultrasonic image by using the detection result of the sensor;
  • an extractor which extracts a blood clot using the photoacoustic image and the ultrasound image.
  • control unit for controlling the laser and the ultrasonic wave generation unit so that the laser pulse generation in the laser and the ultrasonic generation in the ultrasonic generator in turn; can do.
  • the laser pulse may be a laser pulse of the wavelength of the largest thermal expansion of the main component of the thrombus.
  • the embodiments of the present invention by combining the ultrasound image and the photoacoustic image, it is possible to detect the carotid thrombi more effectively.
  • more accurate and faster thrombi detection can be achieved using an esophageal probe with integrated ultrasound and laser.
  • FIG. 1 is a block diagram of a carotid artery thrombosis detection system according to an embodiment of the present invention
  • FIG. 2 is a view showing the structure of the carotid artery probe
  • 3 is a view provided to explain the laser absorption degree
  • FIG. 4 is a block diagram of a transesophageal thrombus detection system according to another embodiment of the present invention.
  • FIG. 5 is a view showing the structure of the esophageal probe.
  • FIG. 6 is a flowchart provided to explain a thrombus detection method according to another embodiment of the present invention.
  • FIG. 1 is a block diagram of a carotid artery thrombosis detection system according to an embodiment of the present invention.
  • the carotid artery thrombosis detection system according to an embodiment of the present invention detects carotid artery thrombi by combining an optoacoustic image and an ultrasound image.
  • Carotid artery thrombosis detection system that performs such a function, as shown in Figure 1, the tunable laser 110, the ultrasonic sensor 120, photoacoustic image generator 130, ultrasonic image generator 140, The image combiner 150, the thrombus extractor 160, the display 170, and the display 180 are included.
  • the tunable laser 110 may generate laser pulses of various wavelengths and irradiate the carotid arteries.
  • the wavelength and generation time / period of the laser pulse generated by the tunable laser 110 are controlled by the controller 180.
  • the carotid artery absorbs the laser pulse irradiated from the wavelength tunable laser 110 and thermally expands, and photoacoustic light is emitted from the carotid artery by this thermal expansion.
  • the ultrasonic sensor 120 is a sensor for detecting photoacoustic light emitted from the carotid artery.
  • FIG. 2 illustrates a carotid artery probe structure including an optical fiber for irradiating a laser pulse generated by the tunable laser 110 to the carotid artery and provided with an ultrasonic sensor 120 for sensing the photoacoustic light emitted from the carotid artery.
  • the photoacoustic detection result by the ultrasonic sensor 120 is applied to the photoacoustic image generator 130.
  • the photoacoustic image generator 130 generates the photoacoustic image from the photoacoustic detection result of the ultrasonic sensor 120.
  • the image generated by the photoacoustic image generating unit 130 is applied to the image combining unit 150.
  • the ultrasound image generator 140 outputs ultrasound to the carotid artery and detects ultrasound reflected from the carotid artery to generate an ultrasound image.
  • the ultrasound image generated by the ultrasound image generator 140 is applied to the image combiner 150.
  • the image combiner 150 combines the photoacoustic image generated by the photoacoustic image generator 130 and the ultrasonic image generated by the ultrasonic image generator 140.
  • the thrombus extraction unit 160 may extract carotid artery thrombi using the photoacoustic image and the ultrasound image.
  • the display 170 displays the combined image generated by the image combiner 150 and the carotid thrombus extraction result by the thrombus extractor 160 and provides the result to the medical staff.
  • Ultrasonography shows the structure of the carotid artery, but it does not distinguish carotid thrombi from other tissues.
  • the thrombus is mainly composed of lipids.
  • the photoacoustics emitted from the lipids irradiated with laser pulses of a specific wavelength are much larger than other tissues, and thus have a large contrast.
  • the lipid has a high absorption of the laser of the 1210nm wavelength, it will emit the largest photoacoustic.
  • the carotid thrombus is searched by combining the structural image of the ultrasound image and the functional image of the photoacoustic image generated by the laser pulse of 1210 nm wavelength.
  • the image combiner 150 may synthesize the ultrasound image and the photoacoustic image to generate a carotid artery image having high contrast of the thrombus portion, and the thrombus extractor 160 generates a difference image between the photoacoustic image and the ultrasound image. Carotid thrombi can be extracted.
  • FIG 4 is a block diagram of a transesophageal thrombus detection system according to another embodiment of the present invention.
  • Transesophageal thrombus detection system according to an embodiment of the present invention is also the same as the thrombus detection system shown in Figure 1 in that the carotid artery thrombus is detected by combining the photoacoustic image and the ultrasound image.
  • the transesophageal thrombus detection system shown in FIG. 4 differs from the thrombus detection system shown in FIG. 1 in that it detects photoacoustics and ultrasound by inserting the transesophageal probe shown in FIG. 5 into the esophagus.
  • transesophageal thrombus detection system shown in FIG. 4 differs from the thrombus detection system shown in FIG. 1 in that one ultrasonic sensor 230 is used to generate photoacoustic and ultrasound images simultaneously. have.
  • Transesophageal thrombus detection system having such a feature, as shown in Figure 4, the tunable laser 210, the ultrasonic generator 220, ultrasonic sensor 230, photoacoustic / The ultrasound image generator 240, the image combiner 250, the thrombus extractor 260, and the display 270 are included.
  • the tunable laser 210 may generate laser pulses of various wavelengths and irradiate the carotid arteries.
  • the wavelength and generation time / period of the laser pulse generated by the tunable laser 210 are controlled by the controller 280.
  • the ultrasound generator 220 generates ultrasound and outputs the ultrasound to the carotid artery.
  • the ultrasound generation unit 220 is controlled by the controller 280 when the generation / period of the ultrasound.
  • the control unit 280 is a laser pulse generation / irradiation by the wavelength tunable laser 210 and the ultrasonic wave generation / output to the ultrasonic wave generator 220, the variable wavelength laser 210 and the ultrasonic wave generator 220 in order To control.
  • the ultrasonic sensor 230 sequentially detects the photoacoustic emitted from the carotid artery by the laser pulse irradiated by the tunable laser 210 and the ultrasonic wave output by the ultrasonic generator 220 and reflected from the carotid artery. do.
  • FIG. 5 illustrates an esophageal probe structure including an optical fiber for irradiating a laser generated by the tunable laser 110 to the carotid artery and provided with the ultrasonic wave generator 220 and the ultrasonic sensor 230.
  • the optoacoustic / ultrasound image generator 240 generates an optoacoustic image using the photoacoustic signal detected by the ultrasonic sensor 230, and generates an ultrasonic image using the ultrasonic signal detected by the ultrasonic sensor 230.
  • the photoacoustic and ultrasonic images generated by the photoacoustic / ultrasound image generating unit 240 are applied to the image combining unit 250.
  • the image combiner 250 combines the photoacoustic image and the ultrasonic image.
  • the thrombus extractor 260 may extract the carotid artery thrombi using the photoacoustic image and the ultrasound image.
  • the display 270 displays the combined image generated by the image combiner 250 and the carotid thrombus extraction result by the thrombus extractor 260 and provides the result to the medical staff.
  • FIG. 6 is a flowchart provided to explain a thrombus detection method according to another embodiment of the present invention.
  • an optoacoustic image is generated using a laser pulse (S310), and an ultrasound image is generated using ultrasonic waves (S320).
  • carotid artery thrombosis detection system transesophageal thrombosis detection system, and thrombus detection method using them have been described in detail with reference to preferred embodiments.
  • Carotid artery thrombus detection presented in the above examples is merely exemplary.
  • the present invention can also be applied to detecting blood clots in blood vessels other than the carotid artery.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Cardiology (AREA)
  • Physiology (AREA)
  • Vascular Medicine (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Acoustics & Sound (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)

Abstract

La présente invention concerne un système et un procédé de détection de plaque. Un système de détection de plaque, selon un mode de réalisation de la présente invention, comprend : un laser destiné à générer une impulsion laser et à exposer le vaisseau sanguin à une partie de celui-ci; un capteur destiné à détecter une émission photoacoustique du vaisseau sanguin qui a été exposé à l'impulsion laser; une unité de génération photoacoustique destinée à générer une image photoacoustique au moyen du résultat de détection du capteur; une unité de génération d'image ultrasonore destinée à générer une image ultrasonore du vaisseau sanguin; et une unité d'extraction destinée à extraire la plaque au moyen de l'image photoacoustique et de l'image ultrasonore. La présente invention permet une détection plus rapide et plus efficace et précise de plaque.
PCT/KR2017/001045 2016-02-05 2017-02-01 Système et procédé de détection de plaque WO2017135658A1 (fr)

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Application Number Priority Date Filing Date Title
KR1020160014696A KR102576682B1 (ko) 2016-02-05 2016-02-05 혈전 탐지 시스템 및 방법
KR10-2016-0014696 2016-02-05

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CN107684440A (zh) * 2017-11-01 2018-02-13 绍兴市中医院 一种血栓的检测方法及其装置
KR102146958B1 (ko) 2018-11-28 2020-08-21 전북대학교산학협력단 광음향 스캔 영상 장치
KR102180436B1 (ko) 2018-11-28 2020-11-18 전북대학교산학협력단 3차원 광음향 영상 장치
KR20240069978A (ko) * 2022-11-14 2024-05-21 국립부경대학교 산학협력단 광음향 영상 및 초음파 영상 획득장치 및 그 방법

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KR20090088909A (ko) * 2006-12-19 2009-08-20 코닌클리케 필립스 일렉트로닉스 엔.브이. 결합된 광음향 및 초음파 이미징 시스템
US20120243760A1 (en) * 2011-03-24 2012-09-27 Takahiro Manabe Plaque region extracting method and apparatus therefor
US20120253180A1 (en) * 2010-10-19 2012-10-04 Stanislav Emelianov Combined ultrasound and photoacoustic imaging of metal objects
JP2013070704A (ja) * 2011-09-26 2013-04-22 Osaka Prefecture Univ 血管プラーク画像診断装置
KR20130081067A (ko) * 2012-01-06 2013-07-16 삼성메디슨 주식회사 초음파 진단 장치 및 방법

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KR102581189B1 (ko) * 2016-02-05 2023-09-20 전북대학교산학협력단 혈전 모니터링을 위한 형광 영상 장치 및 이를 이용한 다중 영상 시스템

Patent Citations (5)

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KR20090088909A (ko) * 2006-12-19 2009-08-20 코닌클리케 필립스 일렉트로닉스 엔.브이. 결합된 광음향 및 초음파 이미징 시스템
US20120253180A1 (en) * 2010-10-19 2012-10-04 Stanislav Emelianov Combined ultrasound and photoacoustic imaging of metal objects
US20120243760A1 (en) * 2011-03-24 2012-09-27 Takahiro Manabe Plaque region extracting method and apparatus therefor
JP2013070704A (ja) * 2011-09-26 2013-04-22 Osaka Prefecture Univ 血管プラーク画像診断装置
KR20130081067A (ko) * 2012-01-06 2013-07-16 삼성메디슨 주식회사 초음파 진단 장치 및 방법

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KR20170093378A (ko) 2017-08-16

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