WO2017129121A1

WO2017129121A1 - Thiadiazole oxime ether strobilurin derivatives, preparation method therefor and use thereof

Info

Publication number: WO2017129121A1
Application number: PCT/CN2017/072554
Authority: WO
Inventors: 范志金; 陈来; 张秩鸣; 张乃楼; 郭晓凤; 朱玉洁; 钱晓琳; 马刘勇; 王海霞; 徐京华; 宋胤奇; 梁福起; 田海丰; 于茂祥
Original assignee: 南开大学
Priority date: 2016-01-26
Filing date: 2017-01-25
Publication date: 2017-08-03

Abstract

The present invention relates to 1,2,3,-thiadiazole oxime ether strobilurin derivatives having a general chemical structure as shown in IV. Provided in the present invention are thiadiazole oxime ether strobilurin derivatives, a preparation method therefor and a use thereof. Disclosed in the present invention is a general structure and a synthesis method for the described compound, as well as a use thereof as an insecticide, fungicide or antiphytoviral agent. Also disclosed is the use thereof in preventing and treating agricultural, forestal or horticultural plant pests, diseases or virus diseases in combination with an agriculturally acceptable promoter or potentiator, a commercially available insecticide, acaricide, fungicide or antiphytoviral agent, and a preparation method thereof.

Description

一类噻二唑肟醚甲氧基丙烯酸酯衍生物及其制备方法和用途Thiazol oxime ether methoxy acrylate derivative, preparation method and use thereof

技术领域Technical field

本发明的技术方案涉及含N含S的噻二唑肟醚甲氧基丙烯酸酯类化合物，具体涉及1,2,3-噻二唑类肟醚化合物，即1,2,3,-噻二唑肟醚甲氧基丙烯酸酯衍生物。The technical scheme of the present invention relates to a thiadiazole oxime ether methoxy acrylate compound containing N, in particular to a 1,2,3-thiadiazole oxime ether compound, namely 1,2,3,-thiadi An oxazolidine methoxy acrylate derivative.

背景技术Background technique

杂环化合物杂环化合物具有高效、低毒、广谱的生物活性，专利文献报道的生物活性化合物中，大部分具有杂环结构；文献报道五元杂环化合物具有植物激活剂、杀菌剂、植物生长调节剂和杀虫剂的活性(陈丹萍.现代农药，2014,14(2):5-10)，其中，噻二唑是重要的五元含氮含硫杂环化合物，在农业领域有商品化的品种如棉花脱叶剂噻苯隆、植物激活剂本并噻二唑(简称BTH)和噻酰菌胺(简称TDL)。发明人所在的课题组发现了甲噻诱胺的诱导抗病活性并进行了产业化开发，创制出我国第一个具有自主知识产权的植物激活品种，该类化合物诱导抗病活性的研究已有一定的报道(Fan Z.J.，et al.J.Agric.Food Chem.,2009,57(10):4279-4286)。The heterocyclic compound heterocyclic compound has high-efficiency, low-toxicity and broad-spectrum biological activity. Most of the biologically active compounds reported in the patent literature have a heterocyclic structure; the five-membered heterocyclic compound has a plant activator, a bactericide, and a plant. Activity of growth regulators and insecticides (Chen Danping. Modern Pesticide, 2014, 14(2): 5-10), wherein thiadiazole is an important five-membered nitrogen-containing sulfur-containing heterocyclic compound, which is commercially available in the agricultural sector. The varieties include cotton defoliant thidiam, plant activator benzothiadiazole (abbreviated as BTH) and thiazide (TDL). The inventor's research group discovered the induced disease resistance of methotrexate and carried out industrial development, and created the first plant-activated variety with independent intellectual property rights in China. The research on the induction of disease resistance by such compounds has been carried out. A certain report (Fan ZJ, et al. J. Agric. Food Chem., 2009, 57(10): 4279-4286).

甲氧基丙烯酸酯类杀菌剂具有广谱的杀菌活性，对几乎所有真菌类(子囊菌纲、担子菌纲、卵菌纲和半知菌类)病害都有很好的活性，如麦类的白粉病、叶枯病、赤斑病、网斑病、黑腥病、水稻的稻瘟病、纹枯病及霜霉病和疫病等(关爱莹.精细与专用化学品，2012,20(4):24-28)。该类药剂具备高效、广谱、低毒、内吸和易降解等多种优点，现已成为全球最主要的农用杀菌剂(袁小勇.2014,34:170-177)。已成功商品化的甲氧基丙烯酸酯类杀菌剂中重要的品种主要有：嘧菌酯(azoxystrobin)、醚菌酯(kresoxim-methyl)、吡唑醚菌酯(pyraclostrobin)、肟菌酯(trifloxystrobin)、氟嘧菌酯(fluoxastrobin)、啶氧菌酯(picoxystrobin)、苯氧菌胺(metaminostrobin)、醚菌胺(dimoxystrobin)、肟醚菌胺(orysastrobin)、烯肟菌酯(enestrobin)、唑菌酯(pyraoxystrobin)、烯肟菌胺(SYP-1620)等。由于Strobilurin类杀菌剂作用位点单一，大量高频高强度使用带来的抗性问题十分突出(Fisher,N.Pest.Manage.Sci.2005,61(10):973-978)；植物激活剂具有光谱持久的***获得抗病性，不直接作用于病原物而作用于植物本身，是21世纪植物保护的重要方向，该类药剂无抗药性的风险，因此，创制更多超过高效的药剂迫在眉睫。The methoxy acrylate fungicide has a broad spectrum of bactericidal activity and is very active against almost all fungi (Ascomycetes, Basidiomycetes, Oomycetes and Deuteromycetes) diseases, such as wheat. Powdery mildew, leaf blight, red spot disease, net blotch, black shank, rice blast, sheath blight and downy mildew and disease (Guan Aiying. Fine and Specialty Chemicals, 2012, 20(4) :24-28). These agents have many advantages such as high efficiency, broad spectrum, low toxicity, systemic absorption and easy degradation. They have become the most important agricultural fungicides in the world (Yuan Xiaoyong. 2014, 34: 170-177). The most important varieties of methoxy acrylate fungicides that have been successfully commercialized are: azoxystrobin, kresoxim-methyl, pyraclostrobin, and trifloxystrobin. ), fluoxastrobin, picoxystrobin, metaminostrobin, dimoxystrobin, oressastrobin, enestrobin, azole Pyraoxystrobin, enestrobin (SYP-1620), and the like. Due to the single action site of Strobilurin fungicides, the resistance problem caused by a large number of high frequency and high intensity applications is very prominent (Fisher, N. Pest. Manage. Sci. 2005, 61 (10): 973-978); plant activators A system with long-lasting spectrum is resistant to disease and does not directly act on the pathogen and acts on the plant itself. It is an important direction for plant protection in the 21st century. This type of agent has no risk of drug resistance. Therefore, it is extremely urgent to create more effective drugs. .

为寻找和发现更加高效、广谱、低毒、低生态风险且无交互抗性的农药先导及侯选化合物，本发明将1,2,3-噻二唑引入甲氧基丙烯酸酯的先导结构中，设计合成了一类噻二唑肟醚甲氧基丙烯酸酯衍生物，并进行了***的生物活性的筛选和评价。In order to find and discover pesticide lead and candidate compounds which are more efficient, broad spectrum, low toxicity, low ecological risk and no cross-resistance, the present invention introduces 1,2,3-thiadiazole into the lead structure of methoxy acrylate. In this paper, a class of thiadiazolone methoxy acrylate derivatives was designed and synthesized, and the biological activity of the system was screened and evaluated.

发明内容Summary of the invention

本发明所要解决的技术问题是：提供一类新的噻二唑肟醚甲氧基丙烯酸酯衍生物的合成方法，提供这类化合物调控农业、园艺和卫生以及林业植物害虫和植物病原物的生物活性及其测定方法，同时提供这些化合物在农业领域、园艺领域、林业领域以及卫生领域中的应用。The technical problem to be solved by the present invention is to provide a new class of thiadiazolidine methoxy acrylate derivatives. A method of providing such compounds for regulating the biological activities of agricultural, horticultural and sanitary, and forestry plant pests and plant pathogens, and methods for their determination, while providing the use of these compounds in the agricultural, horticultural, forestry, and sanitary fields.

本发明解决该技术问题所采用的技术方案是：具有农业领域、园艺领域、林业领域杀虫、杀螨活性、杀菌活性、抗植物病毒活性、诱导植物产生抗病活性的噻二唑肟醚甲氧基丙烯酸酯类化合物的化学结构通式见式Ⅳ：The technical solution adopted by the invention to solve the technical problem is: having thiadiazole ether A in agricultural field, horticultural field, forestry field, insecticidal activity, acaricidal activity, bactericidal activity, anti-plant virus activity, and induction of plant disease resistance activity The chemical structure of the oxy acrylates is shown in Formula IV:

其中，R¹选自：4-甲基-1,2,3-噻二唑-5-基、5-甲基-1,2,3-噻二唑-4-基；R²选自：甲基、氢；R³选自：1,2-二氟乙基、炔丙基、环丙基、甲基、1-甲硫基-2-甲基丙-2-基、(R)-1-甲硫基丙-2-基；X选自：氧、氮,n＝1,2；Z选自：碳、氮。Wherein R ^{1 is} selected from the group consisting of: 4-methyl-1,2,3-thiadiazol-5-yl, 5-methyl-1,2,3-thiadiazol-4-yl; and R ^{2 is} selected from the group consisting of: Methyl, hydrogen; R ^{3 is} selected from: 1,2-difluoroethyl, propargyl, cyclopropyl, methyl, 1-methylthio-2-methylpropan-2-yl, (R)- 1-Methylthiopropan-2-yl; X is selected from the group consisting of: oxygen, nitrogen, n = 1, 2; Z is selected from the group consisting of carbon and nitrogen.

本发明的1,2,3-噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ的合成方法如下：The synthesis method of the 1,2,3-thiadiazolyl ether methoxy acrylate derivative IV of the present invention is as follows:

本发明所述的噻二唑肟醚甲氧基丙烯酸酯衍生物的合成方法分为以下步骤：The method for synthesizing the thiadiazolone methoxy acrylate derivative of the present invention is divided into the following steps:

A.化合物Ⅱ的制备：A. Preparation of Compound II:

在反应瓶中用乙醇将化合物I溶解，加入取代1,2,3-噻二唑羰基化合物，然后向反应体系中滴加盐酸，室温搅拌，反应完全后减压除去溶剂，将残余物纯化，制得化合物Ⅱ；其中，所述1,2,3-噻二唑羰基化合物选自：4-甲基-1,2,3-噻二唑-5-甲醛、4-甲基-1,2,3-噻二唑-5-乙酮、5-甲基-1,2,3-噻二唑-4-甲醛、5-甲基-1,2,3-噻二唑-4-乙酮；The compound I is dissolved in ethanol in a reaction flask, and the substituted 1,2,3-thiadiazole carbonyl compound is added. Then, hydrochloric acid is added dropwise to the reaction system, and the mixture is stirred at room temperature. After the reaction is completed, the solvent is removed under reduced pressure, and the residue is purified. Preparing compound II; wherein the 1,2,3-thiadiazole carbonyl compound is selected from the group consisting of: 4-methyl-1,2,3-thiadiazole-5-formaldehyde, 4-methyl-1,2 , 3-thiadiazol-5-ethanone, 5-methyl-1,2,3-thiadiazole-4-carbaldehyde, 5-methyl-1,2,3-thiadiazole-4-ethyl ketone ;

B.化合物Ⅲ的制备:B. Preparation of Compound III:

在反应瓶中用甲醇将化合物Ⅱ溶解，然后向反应体系中加入氢氧化钠，然后加热回流，反应完全后将反应液浓缩，残余物用乙酸乙酯稀释，再加入水将残余物溶解，分离出水层，水层用盐酸调节pH至3，然后用乙酸乙酯萃取，将有机层用饱和氯化钠洗，无水硫酸钠干燥，抽滤，减压除去溶剂，制得化合物Ⅲ；The compound II was dissolved in methanol in a reaction flask, and then sodium hydroxide was added to the reaction system, followed by heating to reflux. After the reaction was completed, the reaction mixture was concentrated, and the residue was diluted with ethyl acetate. The effluent layer, the aqueous layer is adjusted to pH 3 with hydrochloric acid, and then extracted with ethyl acetate. The organic layer is washed with saturated sodium chloride, dried over anhydrous sodium sulfate, filtered,

C.化合物Ⅳ的制备:C. Preparation of Compound IV:

在反应瓶中用干燥的二氯甲烷将化合物Ⅲ溶解，然后向反应中加入EDCI和HOBT，加完之后室温搅拌，然后向反应体系中加入R³-XH_n，n＝1,2；室温搅拌，反应结束后，反应液用水洗，分离出有机层，有机层分别用饱和碳酸氢钠和饱和氯化钠洗后，无水硫酸钠干燥，抽滤，减压除去溶剂，将残余物纯化，即得到化合物Ⅳ。In the reaction flask, the compound III was dissolved in dry dichloromethane, and then EDCI and HOBT were added to the reaction. After the addition, the mixture was stirred at room temperature, and then R ³ -XH _n , n = 1, 2 was added to the reaction system; After the reaction, the reaction mixture was washed with water, and the organic layer was evaporated. That is, compound IV is obtained.

作为一个优选的实施方案，本发明的噻二唑肟醚甲氧基丙烯酸酯衍生物的合成方法分为以下步骤：As a preferred embodiment, the synthesis method of the thiadiazolyl ether methoxy acrylate derivative of the present invention is divided into the following steps:

A.化合物Ⅱ的制备：A. Preparation of Compound II:

在25毫升单口圆底烧瓶中加入1.10毫摩尔化合物I，用15毫升乙醇溶解，再加入1.00毫摩尔取代1,2,3-噻二唑羰基化合物，所述1,2,3-噻二唑羰基化合物选自：4-甲基-1,2,3-噻二唑-5-甲醛、4-甲基-1,2,3-噻二唑-5-乙酮、5-甲基-1,2,3-噻二唑-4-甲醛、5-甲基-1,2,3-噻二唑-4-乙酮，最后向反应体系中滴加两滴2摩尔/升的盐酸，室温搅拌12小时，反应完全后减压除去溶剂，残余物经200～300目硅胶柱层析纯化得化合物Ⅱ，洗脱剂为60～90摄氏度的石油醚:乙酸乙酯，根据产物的不同，体积比为9:1-2:1，收率70-80％；化合物Ⅱ制备的量和反应容器的体积按相应比例扩大或缩小。Into a 25 ml single-neck round bottom flask, 1.10 mmol of Compound I was added, dissolved in 15 ml of ethanol, and then 1.00 mmol of a substituted 1,2,3-thiadiazole carbonyl compound, 1,2,3-thiadiazole, was added. The carbonyl compound is selected from the group consisting of: 4-methyl-1,2,3-thiadiazol-5-carboxaldehyde, 4-methyl-1,2,3-thiadiazol-5-ethanone, 5-methyl-1 , 2,3-thiadiazole-4-carbaldehyde, 5-methyl-1,2,3-thiadiazole-4-ethyl ketone, and finally add two drops of 2 mol/L hydrochloric acid to the reaction system at room temperature After stirring for 12 hours, the solvent is removed under reduced pressure, and the residue is purified by silica gel column chromatography from 200 to 300 mesh to afford compound II, eluent: petroleum ether: ethyl acetate, 60-90 ° C, depending on the product, volume The ratio is 9:1-2:1, the yield is 70-80%; the amount of the compound II prepared and the volume of the reaction vessel are expanded or reduced in a corresponding ratio.

B.化合物Ⅲ的制备:B. Preparation of Compound III:

在25毫升单口圆底烧瓶中加入0.24毫摩尔化合物Ⅱ，用15毫升甲醇溶解，向反应中加入0.03克，即0.72毫摩尔氢氧化钠，然后加热回流30分钟，反应结束后将反应液浓缩，残余物用10毫升乙酸乙酯稀释，加入10毫升的水将固体全部溶解，分离出水层，水层用2摩尔/升的盐酸调节pH至3，然后用乙酸乙酯萃取，水层用乙酸乙酯反萃一遍，合并有机层，有机层用饱和氯化钠洗一遍，无水硫酸钠干燥，抽滤，减压除去溶剂，得化合物Ⅲ；收率95-100％；化合物Ⅲ制备的量和反应容器的体积按相应比例扩大或缩小。To a 25 ml single-necked round bottom flask was added 0.24 mmol of Compound II, dissolved in 15 ml of methanol, and 0.03 g of 0.72 mmol of sodium hydroxide was added to the reaction, followed by heating under reflux for 30 minutes. After the reaction was completed, the reaction mixture was concentrated. The residue was diluted with 10 ml of ethyl acetate. The solid was completely dissolved by adding 10 ml of water. The aqueous layer was separated. The aqueous layer was adjusted to pH 3 with 2 mol/L hydrochloric acid, and then extracted with ethyl acetate. The ester was back-extracted, and the organic layer was combined. The organic layer was washed with saturated sodium chloride and dried over anhydrous sodium sulfate, filtered, and then evaporated to remove solvent to afford compound III; yield 95-100%; The volume of the reaction vessel is enlarged or reduced in proportion to the corresponding ratio.

C.化合物Ⅳ的制备:C. Preparation of Compound IV:

在25毫升单口圆底烧瓶中加入0.30毫摩尔化合物Ⅲ，用15毫升干燥的二氯甲烷溶解，向反应中加入0.69克，即0.36毫摩尔的EDCI，即1-乙基-(3-二甲基氨基丙基)碳二亚胺盐酸盐和0.43克，即0.32毫摩尔的HOBT，即1-羟基苯并三氮唑，加完之后室温搅拌30分钟，然后向反应体系中加入0.32毫摩尔的R³-XH_n，n＝1,2；室温搅拌2小时，反应结束后，反应液用15毫升的水洗两遍，分离出有机层，有机层分别用饱和碳酸氢钠和饱和氯化钠各洗一遍，无水硫酸钠干燥，抽滤，减压除去溶剂，残余物经200～300目硅胶柱层析纯化得到白色固体，洗脱剂为60～90摄氏度的石油醚:乙酸乙酯，体积比为4:1，收率30％-95％；化合物Ⅳ制备的量和反应容器的体积按相应比例扩大或缩小。To a 25 ml single-neck round bottom flask was added 0.30 mmol of compound III, dissolved in 15 ml of dry dichloromethane, and 0.69 g, ie 0.36 mmol of EDCI, ie 1-ethyl-(3-dimethyl) was added to the reaction. Base aminopropyl) carbodiimide hydrochloride and 0.43 g, ie 0.32 mmol of HOBT, ie 1-hydroxybenzotriazole, after stirring at room temperature for 30 minutes, then adding 0.32 mmol to the reaction system R ³ -XH _n , n = 1, 2; stirring at room temperature for 2 hours, after the reaction is completed, the reaction solution is washed twice with 15 ml of water, and the organic layer is separated, and the organic layer is respectively saturated sodium hydrogen carbonate and saturated sodium chloride Each was washed once, dried over anhydrous sodium sulfate, suction filtered, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography from 200 to 300 mesh to afford white solid. The volume ratio is 4:1, the yield is 30%-95%; the amount of compound IV prepared and the volume of the reaction vessel are expanded or reduced in corresponding proportions.

本发明还提供了所述的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ在制备杀菌剂中的用途。The invention also provides the use of the thiadiazolyl ether methoxy acrylate derivative IV in the preparation of a bactericide.

本发明还提供了所述的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ在制备抗烟草花叶病毒剂中的用途。 The invention also provides the use of the thiadiazolium ether methoxy acrylate derivative IV in the preparation of an anti-tobacco mosaic virus agent.

本发明还提供了所述的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ在制备植物激活剂用于诱导烟草抗烟草花叶病毒中的用途。The invention also provides the use of the thiadiazolium ether methoxy acrylate derivative IV for the preparation of a plant activator for inducing tobacco against tobacco mosaic virus.

本发明还提供了所述的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ在防治农业和林业以及园艺植物虫害中的用途。The invention also provides the use of the thiadiazolyl ether methoxy acrylate derivative IV for controlling agricultural and forestry and horticultural plant pests.

优选地，所述噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ与农业化学品共同施用；优选地，所述农业化学品选自：杀虫剂、杀菌剂、抗植物病毒剂、杀螨剂中的一种或几种。Preferably, the thiadiazolone methoxy acrylate derivative IV is co-administered with an agricultural chemical; preferably, the agricultural chemical is selected from the group consisting of: an insecticide, a bactericide, an anti-plant virus agent, and a mites One or several of the agents.

优选地，所述的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ与所述杀虫剂中的任意一种或两种组合形成杀虫组合物用于防治农业和林业以及园艺植物虫害；Preferably, the thiadiazolone methoxy acrylate derivative IV is combined with any one or both of the insecticides to form a pesticidal composition for controlling agricultural and forestry and horticultural plant pests;

优选地，所述杀虫剂选自：毒死蜱、地亚哝、啶虫脒、甲氨基阿维菌素、弥拜菌素、阿维菌素、多杀菌素、氰戊菊酯、高效氰戊菊酯、氯氰菊酯、高效氯氰菊酯、三氟氯氰菊酯、溴氰菊酯、甲氰菊酯、Beta-氟氯氰菊酯、Lambda-三氟氯氰菊酯、二氯苯醚菊酯、苄氯菊酯、丙烯菊酯、联苯菊酯、氯菊酯、醚菊酯、氟氯苯菊酯、氯氟胺氰戊菊酯、吡虫啉、烯啶虫胺、氯噻啉、噻虫啉、噻虫嗪、噻虫胺、呋虫胺、可尼丁、达特南、除虫脲、灭幼脲、伏虫隆、除虫隆、氟铃脲、氟虫脲、啶虫隆、虱螨脲、毒虫脲、氟幼脲、Noviflumuron即多氟脲，其CAS号为121451-02-3、氟螨脲、Novaluron即双苯氟脲、氟啶脲、Bay sir 6874即{1-[(3.5-二氯-4)4-硝基苯氧基苯基3-3-(2-氯苯)-脲}、Bay SIR-8514即[1-(4-三氟甲氧基苯基)-3-(2-氯苯)-脲]、嗪虫脲、Bistrifluron即双三氟虫脲、呋喃虫酰肼、虫酰肼、氯虫酰肼、甲氧虫酰肼、环虫酰肼、乐果、氧化乐果、敌敌畏、乙酰甲胺磷、***磷、喹硫磷、哒嗪硫磷、氯唑磷、叶蝉散、西维因、抗蚜威、速灭威、异丙威、杀螟丹、仲丁威、叶飞散、甲萘威、丙硫克百威、丁硫克百威、杀螟丹、溴螨酯、噻螨酮、唑螨酯、哒螨酮、四螨嗪、炔螨特、丁醚脲、吡蚜酮、螺螨酯、螺虫酯、螺虫乙酯、丁烯氟虫腈、***锡、噻嗪酮、灭线磷、氟虫腈、杀虫单、杀虫双、氯虫酰胺、氟虫酰胺、氟氰虫酰胺、氰虫酰胺、唑虫酰胺、溴虫腈、吡嗪酮、乙螨唑、吡螨胺、哒幼酮、吡丙醚、埃玛菌素；Preferably, the insecticide is selected from the group consisting of: chlorpyrifos, scorpion guanidine, acetamiprid, emamectin, imipenem, avermectin, spinosyn, fenvalerate, high-efficiency acetonide Pyrethroid, cypermethrin, beta-cypermethrin, cyhalothrin, deltamethrin, fenpropathrin, Beta-cyfluthrin, Lambda-cyhalothrin, permethrin, permethrin, methrin, hydrazine Pyrethrin, permethrin, fenthrin, flumethrin, flufenacetate, imidacloprid, nitenpyram, chlorothiazide, thiacloprid, thiamethoxam, clothianidin, fur Nicotinamide, cotinine, Dartnam, diflubenzuron, chlorbenzuron, flubenzuron, chlorfenapyr, hexaflumuron, flubenzuron, acetamiprid, guanidine, chlorpyrifos, flubenzuron, Noviflumuron is a polyfluorourea with a CAS number of 121451-02-3, fluoroquinone urea, Novaluron, ie, diphenylfluorourea, chlorfluazuron, and Bay sir 6874, ie {1-[(3.5-dichloro-4)4-nitrate Phenoxyphenyl 3-3-(2-chlorophenyl)-urea}, Bay SIR-8514 is [1-(4-trifluoromethoxyphenyl)-3-(2-chlorophenyl)-urea ], oxazide, Bistrifluron, bis-trifluoroidazolium, furanyl hydrazide, tebufenozide Chloramphenic acid hydrazide, methoxyfenhydrazide, chlorfenapyr, dimethoate, omethoate, dichlorvos, acephate, triazophos, quetiapine, pyridazin, chlorpyrifos, leaching , Xiweiyin, Kangwei, Kuweiwei, Weiweiwei, Zhidan, Zhongdingwei, Yefeisan, Jia Naiwei, propyl thiocarbamate, butyl thiocarb, chlorpyrifos, bromine Ester, thiazolone, oxazolidine, anthrone, tetrazine, alkyne, dibutyl ether urea, pymetrozine, spirodecyl ester, spirotetramat, spirotetramat, butene fipronil, three Zolazole, buprofezin, chlorpyrifos, fipronil, insecticidal, insecticidal, chlorantranil, flubendiamide, flufenamide, cyanamide, azole, chlorfenapyr, pyrazine Ketone, etoxazole, pyridoxamine, ketone, pyriproxyfen, emamectin;

优选地，所述的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ在所述杀虫组合物中的质量百分含量是1％-90％；Preferably, the thiadiazolium ether methoxy acrylate derivative IV is present in the pesticidal composition in an amount of from 1% to 90% by mass;

优选地，所述的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ与所述杀虫剂的比例为质量百分比1％∶99％到99％∶1％；Preferably, the ratio of the thiadiazolone methoxy acrylate derivative IV to the insecticide is 1% by mass: 99% to 99%: 1% by mass;

优选地，所述杀虫组合物加工的剂型选自：种子处理乳剂、水乳剂、微乳剂、悬乳剂、胶囊悬浮剂、水溶性粒剂、细粒剂、可溶性浓剂、毒谷、块状毒饵、粒状毒饵、片状毒饵、浓毒饵、缓释块、静电喷雾剂、水包油乳剂、烟雾罐、烟雾烛、烟雾筒、烟雾棒、烟雾片、烟雾丸、发气剂、油膏、热雾剂、冷雾剂、气雾剂、固/液混合装剂、液/液混合装剂、固/固混合装剂、药漆、微粒剂、追踪粉剂、油悬剂、油分散性粉剂、浓胶剂、泼浇剂、种衣剂、涂抹剂、成膜油剂、超低容量液剂、蒸汽释放剂；Preferably, the dosage form processed by the pesticidal composition is selected from the group consisting of: seed treatment emulsion, water emulsion, microemulsion, suspoemulsion, capsule suspension, water-soluble granule, fine granule, soluble concentrate, poisonous valley, lumps Poison baits, granular baits, flake baits, concentrated baits, slow release blocks, electrostatic sprays, oil-in-water emulsions, smoke cans, smoke candles, smoke tubes, smoke sticks, smoke sheets, Smoke pill, gas generator, ointment, hot spray, cold spray, aerosol, solid/liquid mixture, liquid/liquid mixture, solid/solid mixture, paint, microparticles, tracking Powder, oil suspension, oil dispersible powder, thick glue, pouring agent, seed coating agent, spread agent, film forming oil agent, ultra low volume liquid agent, steam release agent;

优选地，所述杀虫组合物防治的植物虫害选自：红蜘蛛、东亚飞蝗、云斑车蝗、中华稻蝗、日本黄脊蝗、单刺蝼蛄、东方蝼蛄、稻蓟马、烟蓟马、温室蓟马、稻管蓟马、麦简管蓟马、温室白粉虱、烟粉虱、黑尾叶蝉、大青叶蝉、棉叶蝉、斑衣蜡蝉、褐飞虱、白背飞虱、灰飞虱、甘蔗扁角飞虱、棉蚜、麦二叉蚜、麦长管蚜、桃蚜、高粱蚜、萝卜蚜、吹绵蚧、桑盾蚧、矢尖盾蚧、梨圆蚧、白蜡虫、红蜡蚧、朝鲜球坚蚧、梨网蝽、香蕉网蝽、细角花蝽、微小花蝽、针缘蝽、稻蛛缘蝽、稻褐蝽、稻黑蝽、稻绿蝽、绿盲蝽、苜蓿盲蝽、中黑盲蝽、大草蛉、丽草蛉、中华草蛉、谷蛾、衣蛾、黄刺蛾、褐刺蛾、扁刺蛾、麦蛾、棉红铃虫、甘薯麦蛾、小菜蛾、桃小食心虫、大豆食心虫、桃小食心虫、苹果顶梢卷叶蛾、褐带长卷叶蛾、拟小黄卷叶蛾、二化螟、豆荚螟、玉米螟、三化螟、菜螟、稻纵卷叶螟、条螟、棉卷叶野螟、桃蛀螟、黏虫、斜纹夜蛾、稻螟蛉、棉小造桥虫、甜菜夜蛾、大螟、棉铃虫、鼎点金刚钻、小地老虎、大地老虎、黄地老虎、盗毒蛾、舞毒蛾、甘薯天蛾、豆天蛾、直纹稻弄蝶、隐纹谷弄蝶、柑橘凤蝶、玉带凤蝶、菜粉蝶、苎麻赤蛱蝶、苎麻黄蛱蝶、豆芫菁、金星步甲、皱鞘步甲、麦穗步甲、沟金针虫、细胸金针虫、谷斑皮蠹、黑皮蠹、柑橘小吉丁虫、金缘吉丁虫、黄粉虫、黑粉虫、赤拟谷盗、杂拟谷盗、铜绿异丽金龟、暗黑金龟、华北大黑鳃金龟、桑天牛、星天牛、橘褐天牛、桃红颈天牛、大猿叶虫、小猿叶虫、黄守瓜、黄曲条跳甲、绿豆象、豌豆象、蚕豆象、玉米象、米象、小麦叶蜂、梨实蜂、黄带姬蜂、黏虫白星姬蜂、螟蛉悬茧姬蜂、棉铃虫齿唇姬蜂、螟黑点疣姬蜂、蚊、蝇、虻、麦红吸浆虫、麦黄吸浆虫、稻瘿蚊、柑橘大实蝇、瓜实蝇、麦叶灰潜蝇、美洲斑潜蝇、豆秆黑潜蝇、麦秆蝇、种蝇、葱蝇、萝卜蝇、伞裙追寄蝇、玉米螟厉寄蝇、黏虫；Preferably, the plant pests controlled by the insecticidal composition are selected from the group consisting of: red spider, oriental planthopper, cloud locust, Chinese rice blast, Japanese yellow ridge, single locust, oriental carp, rice locust, and tobacco Horse, greenhouse thrips, rice tube thrips, wheat tube horses, greenhouse whitefly, whitefly, black-tailed leafhopper, big green leafhopper, cotton leafhopper, spotted waxhopper, brown planthopper, white-backed planthopper , Laodelphax striatellus, sugarcane, flat-horned corn fly, cotton aphid, wheat bifurcation, wheat long tube, peach aphid, sorghum, radish, blown, sang shield, yam shield, pear round, White wax insects, red wax mites, Korean ball glutinous rice, pear net mites, banana net mites, fine-horned flower buds, tiny flower buds, needle-edge mites, rice spider mites, rice brown mites, rice black mites, rice green mites, Green-spotted scorpion, scorpion scorpion, black-spotted scorpion, large grass scorpion, cypress, Chinese grass scorpion, valley moth, clothing moth, yellow thorn moth, brown thorn moth, spur moth, wheat moth, cotton bollworm, Sweet potato moth, diamondback moth, peach small heartworm, soybean heartworm, peach small heartworm, apple tip leaf moth, brown leaf moth, pseudo-small leaf moth, stem borer, bean pod Corn borer, stem borer, rapeseed meal, rice leaf roller, barley, cotton leaf bark, peach aphid, armyworm, Spodoptera litura, rice bran, cotton small bridgeworm, beet armyworm, giant salamander , cotton bollworm, Ding Ding diamond, small tiger, earth tiger, yellow tiger, poisonous moth, gypsy moth, sweet potato hawk moth, bean hawk moth, straight grain rice butterfly, cryptic valley butterfly, citrus swallow butterfly, jade belt Swallowtail butterfly, cabbage butterfly, ramie red butterfly, ramie butterfly, bean phthalocyanine, Venus carapace, wrinkle sheath, armor, wheat burdock, echinoderma, scutellaria, variegata, black skin蠹, citrus small jiding insects, Jinyuan jiding insects, yellow mealworms, black mealworms, red worms, miscellaneous pirates, patina, golden tortoises, dark golden tortoises, North China black scorpion, sangtian cattle, star days Cow, Orange Brown Beech, Peach Red-necked Beef, Big Leafhopper, Small Leafhopper, Yellow Cucumber, Yellow-curved Flea, Green Bean, Pea, Broad Bean, Corn, Rice, Wheat Leaf, Pear Real bees, yellow-banded bees, sticky insects, white-spotted bee, stag beetle, cotton bollworm, beetle, bee, black-spotted bee, mosquito, fly, dragonfly Wheat red worm, wheat yellow worm, rice blast, citrus fruit fly, melon flies, larvae, larvae, stalk snail, stalk fly, fly, onion fly, radish fly , umbrella skirts to catch flies, corn scorpion flies, sticky insects;

优选地，所述杀虫组合物防治的植物选自：稻谷、小麦、大麦、燕麦、玉米、高粱、甘薯、马铃薯、木薯、大豆、荷兰豆、蚕豆、豌豆、绿豆、小豆、棉花、蚕桑、花生、油菜、芝麻、向日葵、甜菜、甘蔗、咖啡、可可、人参、贝母、橡胶、椰子、油棕、剑麻、烟草、番茄、辣椒、萝卜、黄瓜、白菜、芹菜、榨菜、甜菜、油菜、葱、大蒜、西瓜、甜瓜、哈密瓜、木瓜、苹果、柑桔和桃树、茶、山野菜、竹笋、啤酒花、胡椒、香蕉、番木瓜、兰花、盆景。Preferably, the plant controlled by the pesticidal composition is selected from the group consisting of: rice, wheat, barley, oats, corn, sorghum, sweet potato, potato, tapioca, soybean, pea, broad bean, pea, mung bean, adzuki bean, cotton, sericulture, peanut , rapeseed, sesame, sunflower, beet, sugar cane, coffee, cocoa, ginseng, fritillary, rubber, coconut, oil palm, sisal, tobacco, tomato, pepper, radish, cucumber, cabbage, celery, mustard, beet, rape, Onions, garlic, watermelon, melon, cantaloupe, papaya, apple, citrus and peach, tea, wild vegetables, bamboo shoots, hops, pepper, banana, papaya, orchid, bonsai.

优选地，所述的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ与所述杀菌剂中的任意一种或两种组合形成杀菌组合物用于防治农业和林业以及园艺植物病害； Preferably, the thiadiazolone methoxy acrylate derivative IV is combined with any one or both of the bactericides to form a bactericidal composition for controlling agricultural and forestry and horticultural plant diseases;

优选地，所述杀菌剂选自：苯并噻二唑、噻酰菌胺，简写为TDL、噻酰胺、甲噻诱胺、4-甲基-1,2,3-噻二唑-5-甲酸、4-甲基-1,2,3-噻二唑-5-甲酸钠、4-甲基-1,2,3-噻二唑-5-甲酸乙酯、DL-β-氨基丁酸、异噻菌胺，其英文通用名为：isotianil、3,4-二氯异噻唑-5-甲酸、3,4-二氯异噻唑-5-甲酸钠、3,4-二氯异噻唑-5-甲酸乙酯、病毒唑、安托芬、宁南霉素或水杨酸、霜脲氰、福美双、福美锌、代森锰锌、乙磷铝、甲基硫菌灵、百菌清、敌可松、腐霉利、苯锈啶、甲基托布津、托布津、精甲霜灵、氟吗啉、烯酰吗啉、高效甲霜灵、高效苯霜灵、双氯氰菌胺、磺菌胺、甲磺菌胺、噻氟菌胺、氟酰胺、叶枯酞、环丙酰菌胺、环氟菌胺、环酰菌胺、氰菌胺、硅噻菌胺、呋吡菌胺、吡噻菌胺、双炔酰菌胺、苯酰菌胺、甲呋酰胺、萎锈灵、乙菌利、异菌脲、嘧菌酯、醚菌胺、氟嘧菌酯、醚菌酯、苯氧菌胺、肟醚菌胺、啶氧菌酯、唑菌胺酯、肟菌酯、烯肟菌酯、烯肟菌胺、氧环唑、糠菌唑、环丙唑醇、苯醚甲环唑、烯唑醇、高效烯唑醇、氟环唑、腈苯唑、氟喹唑、氟硅唑、粉唑醇、己唑醇、亚胺唑、种菌唑、叶菌唑、腈菌唑、戊菌唑、丙环唑、丙硫菌唑、硅氟唑、戊唑醇、四氟醚唑、***醇、灭菌唑、联苯***醇、噻菌灵、麦穗宁、抑霉唑、高效抑霉唑、咪鲜胺、氟菌唑、氰霜唑、咪唑菌酮、噁咪唑、稻瘟酯、噁唑菌酮、啶菌噁唑、噁霉灵、噁霜灵、噻唑菌胺、土菌灵、辛噻酮、苯噻硫氰、十二环吗啉、丁苯吗啉、十三吗啉、拌种咯、咯菌腈、氟啶胺、啶斑肟、环啶菌胺、啶酰菌胺、氟啶酰菌胺、啶菌胺、嘧菌环胺、氟嘧菌胺、嘧菌腙、嘧菌胺、嘧霉胺、氯苯嘧啶醇、氟苯嘧啶醇、灭螨猛、二氰蒽醌、乙氧喹啉、羟基喹啉、丙氧喹啉、苯氧喹啉、乙霉威、异丙菌胺、苯噻菌胺、霜霉威、磺菌威、敌瘟磷、异稻瘟净、吡菌磷、甲基立枯磷、灭瘟素、春雷霉素、多抗霉素、多氧霉素、有效霉素、井冈霉素、链霉素、甲霜灵、呋霜灵、苯霜灵、呋酰胺、灭锈胺、多菌灵、苯菌灵、甲基硫菌灵、***酮、乙嘧酚磺酸酯、二甲嘧酚、乙嘧酚、敌菌丹、克菌丹、灭菌丹、乙烯菌核利、氟氯菌核利、菌核净、百菌清、稻瘟灵、稻瘟净、叶枯唑、五氯硝基苯、丙森锌、三乙膦酸铝、硫磺、波尔多液、硫酸铜、氧氯化铜、氧化亚铜、氢氧化铜、苯菌酮、戊菌隆、哒菌酮、四氯苯酞、咯喹酮、螺环菌胺、三环唑、嗪胺灵、多果啶、双胍辛盐、双胍辛胺、氯硝胺、苯磺菌胺、甲苯磺菌胺、吲哚酯、敌磺钠、喹菌酮、烯丙苯噻唑、溴硝醇、碘甲烷、威百亩、敌线酯、棉隆、二氯异丙醚、噻唑磷、硫线磷、丰索磷、虫线磷、苯线磷、灭线磷、除线磷、氯唑磷、丁硫环磷、杀线威、涕灭威、克百威、硫酰氟、二氯丙烯、二氯异烟酸、烯丙异噻唑；Preferably, the bactericide is selected from the group consisting of: benzothiadiazole, thiazide, abbreviated as TDL, thiazamide, methyl thiazide, 4-methyl-1,2,3-thiadiazole-5- Formic acid, sodium 4-methyl-1,2,3-thiadiazol-5-carboxylate, ethyl 4-methyl-1,2,3-thiadiazol-5-carboxylate, DL-β-aminobutyric acid, Isotianil, its common name in English is: isotianil, 3,4-dichloroisothiazol-5-carboxylic acid, 3,4-dichloroisothiazol-5-formate, 3,4-dichloroisothiazol-5- Ethyl formate, ribavirin, antofin, nymidine or salicylic acid, cymoxanil, thiram, thiram, mancozeb, ethylphosphoric acid, thiophanate, chlorothalonil, enemy Cortisone, procymidone, benzopyridin, methyl thiophanate, thiophanate, refined metalaxyl, flumorph, enoylmorpholine, high-performance metalaxyl, high-efficiency benzoxanthin, chloramphenicol, sulfonate Bismuthamide, mesalamide, thifluzamide, fluamide, leaf cumin, cyclopropionamide, cycloflufenamide, fenhexamid, cyanamide, thiastrobin, flufenamide, Pentimidamide, dipropiylamide, benzilamide, mefenamide, wilting, etoxin, iprodione, azoxystrobin, fenfluramine, fluoxastrobin Epoxystrobin, phenoxystrobin, difloxacin, picoxystrobin, pyraclostrobin, trifloxystrobin, enestrobin, enestrobin, oxycyclazole, carbendazole, cyproconazole , difenoconazole, diniconazole, high-efficiency diniconazole, epoxiconazole, nitrile azole, fluoroquinazole, flusilazole, fluconazole, hexaconazole, imidazole, inocastazole, leaf fungus Azole, myclobutanil, penconazole, propiconazole, prothioconazole, silicon fluoride, tebuconazole, tetrafluoroetherazole, triazole alcohol, sterilized azole, biphenyl triazole alcohol, thiabendazole, Maisuining, imazalil, high-efficiency imazalil, prochloraz, fluconazole, cyanoxazole, imidazolone, moxalimid, rice sterol ester, famoxadone, pyridine oxazole, carbendazim, Ointment, ethaboxam, carbendazim, octyl ketone, thiothiazide, dodecaline morpholine, butyl morpholine, thirteen morpholine, seed dressing, fludioxonil, fluazinam, pyridine Cantharidin, Cycloheximide, boscalid, fluaziram, azoxystrobin, cyprodinil, fluzalazine, azoxystrobin, azoxystrobin, pyrimethanil, chlorpyrimidine, Fluoropyrimidin, chlorpyrifos, dicyanoquinone, ethoxyquin, quinolin, C Quinoline, phenoxyquinoline, carbendazim, isopropylidene, phenothiamine, propamocarb, sulfavir, enemies, diarrhea, pyridoxine, methyl chlorpyrifos, chlorpyrifos Alizarin, Chunleimycin, Polymycin, Polyoxomycin, Adamycin, Jinggangmycin, Streptomycin, Metalaxyl, Furosemide, Benzocycline, Furfuramide, Detergent, Polysaccharide Ling, benomyl, thiophanate-methyl, triadimefon, acetaminophen sulfonate, dipyridamole, acetem, chlorpyrifos, captan, sterilized dan, vinyl nucleus, fluoride Chlorella, sclerotium, chlorothalonil, indigo, rice bran, leaf azole, pentachloronitrobenzene, zinc propyl, aluminum triethylphosphonate, sulfur, Bordeaux, copper sulfate, oxygen Copper chloride, cuprous oxide, copper hydroxide, benomyl, pentosan, chlorhexidine, tetrachlorophenyl hydrazine, praziquantel, spiroxylamine, tricyclazole, pyridazin, polyglycine, Bismuth octyl salt, bis-octylamine, chloramine, sulfonamide, toluidine, oxime ester, sodium sulfonate, quinocodone, allyl benzothiazole, bronopol, methyl iodide, Weibaimu, Enemy ester, cotton, dichloroisopropyl ether, thiazolyl, Sulfur, phosphorus, phenophos, insect phosphorus, benzene phosphorus, phosphine, phosphatidylcholine, chlorpyrifos, sulphur cyclophosphine, chlorpyrifos, aldicarb, carbofuran, sulfuryl fluoride, two Chloropropene, dichloroisonicotinic acid, allyl isothiazole;

优选地，所述的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ在所述杀菌组合物中的总的质量百分含量是1％-90％； Preferably, the total mass percentage of the thiadiazolyl ether methoxy acrylate derivative IV in the germicidal composition is from 1% to 90%;

优选地，所述的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ与所述杀菌剂的比例为质量百分比1％∶99％到99％∶1％；Preferably, the ratio of the thiadiazolone methoxy acrylate derivative IV to the bactericide is 1% by mass: 99% to 99%: 1% by mass;

优选地，所述杀菌组合物加工的剂型选自：种子处理乳剂、水乳剂、微乳剂、悬乳剂、胶囊悬浮剂、水溶性粒剂、细粒剂、可溶性浓剂、毒谷、块状毒饵、粒状毒饵、片状毒饵、浓毒饵、缓释块、静电喷雾剂、水包油乳剂、烟雾罐、烟雾烛、烟雾筒、烟雾棒、烟雾片、烟雾丸、发气剂、油膏、热雾剂、冷雾剂、气雾剂、固/液混合装剂、液/液混合装剂、固/固混合装剂、药漆、微粒剂、追踪粉剂、油悬剂、油分散性粉剂、浓胶剂、泼浇剂、种衣剂、涂抹剂、成膜油剂、超低容量液剂、蒸汽释放剂；Preferably, the bactericidal composition is processed in a dosage form selected from the group consisting of: seed treatment emulsion, water emulsion, microemulsion, suspoemulsion, capsule suspension, water-soluble granule, fine granule, soluble concentrate, poisonous valley, block bait , granular bait, flake bait, concentrated bait, slow release block, electrostatic spray, oil-in-water emulsion, smoke can, smoke candle, smoke tube, smoke stick, smoke sheet, smoke pill, gas generator, ointment, heat Spray, cold spray, aerosol, solid/liquid mixed charge, liquid/liquid mixed charge, solid/solid mixed charge, lacquer, microparticle, trace powder, oil suspension, oil dispersible powder, Thickener, pouring agent, seed coating agent, smear agent, film forming oil agent, ultra low volume liquid agent, steam release agent;

优选地，所述杀菌组合物防治的植物病害选自：稻苗绵腐病、番茄根腐病、马铃薯晚疫病、烟草黑胫病、谷子白粉病、葡萄霜霉病、莴苣霜霉病、黄瓜霜霉病、黄瓜炭疽病；Preferably, the plant disease controlled by the bactericidal composition is selected from the group consisting of: rice seedling cotton rot, tomato root rot, potato late blight, tobacco black shank, millet powdery mildew, grape downy mildew, lettuce downy mildew, cucumber Downy mildew, cucumber anthracnose;

优选地，所述杀菌组合物适用的植物选自：稻谷、小麦、大麦、燕麦、玉米、高粱、甘薯、马铃薯、木薯、大豆、荷兰豆、蚕豆、豌豆、绿豆、小豆、棉花、蚕桑、花生、油菜、芝麻、向日葵、甜菜、甘蔗、咖啡、可可、人参、贝母、橡胶、椰子、油棕、剑麻、烟草、番茄、辣椒、萝卜、黄瓜、白菜、芹菜、榨菜、甜菜、油菜、葱、大蒜、西瓜、甜瓜、哈密瓜、木瓜、苹果、柑桔和桃树、茶、山野菜、竹笋、啤酒花、胡椒、香蕉、番木瓜、兰花、盆景。Preferably, the bactericidal composition is suitable for plants selected from the group consisting of: rice, wheat, barley, oats, corn, sorghum, sweet potato, potato, cassava, soybean, pea, broad bean, pea, mung bean, adzuki bean, cotton, sericulture, peanut, Rape, sesame, sunflower, beet, sugar cane, coffee, cocoa, ginseng, fritillary, rubber, coconut, oil palm, sisal, tobacco, tomato, pepper, radish, cucumber, cabbage, celery, mustard, beet, rape, onion , garlic, watermelon, melon, cantaloupe, papaya, apple, citrus and peach, tea, wild vegetables, bamboo shoots, hops, pepper, banana, papaya, orchid, bonsai.

优选地，所述的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ与所述抗病毒药剂中的任意一种或两种组合形成抗病毒组合物用于防治农业和林业以及园艺植物病毒病害；Preferably, the thiadiazolone methoxy acrylate derivative IV is combined with any one or both of the antiviral agents to form an antiviral composition for controlling agricultural and forestry and horticultural plant virus diseases. ;

优选地，所述抗病毒药剂选自：苯并噻二唑、噻酰菌胺，简写为TDL、异噻菌胺，其英文通用名为：isotianil、4-甲基-1,2,3-噻二唑-5-甲酸、4-甲基-1,2,3-噻二唑-5-甲酸钠、4-甲基-1,2,3-噻二唑-5-甲酸乙酯、3,4-二氯异噻唑-5-甲酸、3,4-二氯异噻唑-5-甲酸钠、3,4-二氯异噻唑-5-甲酸乙酯、DL-β-氨基丁酸、病毒唑、安托芬、宁南霉素、噻酰胺、甲噻诱胺或水杨酸、嘧肽霉素、二氯异烟酸、烯丙异噻唑、井冈羟胺、井冈霉素；Preferably, the antiviral agent is selected from the group consisting of: benzothiadiazole, thiazide, abbreviated as TDL, isotianil, and its common name in English is: isotianil, 4-methyl-1,2,3- Thiadiazole-5-carboxylic acid, sodium 4-methyl-1,2,3-thiadiazole-5-carboxylate, ethyl 4-methyl-1,2,3-thiadiazole-5-carboxylate, 3, 4-Dichloroisothiazol-5-carboxylic acid, 3,4-dichloroisothiazol-5-formate, 3,4-dichloroisothiazol-5-carboxylic acid ethyl ester, DL-β-aminobutyric acid, ribavirin, Antofin, ningnanmycin, thiazamide, methyl thiazide or salicylic acid, glutathione, dichloroisonicotinic acid, allylisothiazole, Jinggang hydroxylamine, Jinggangmycin;

优选地，所述的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ在所述抗病毒组合物中的总的质量百分含量是1％-90％；Preferably, the total mass percentage of the thiadiazolone methoxy acrylate derivative IV in the antiviral composition is from 1% to 90%;

优选地，所述的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ与所述抗植物病毒剂的比例为质量百分比1％∶99％到99％∶1％；Preferably, the ratio of the thiadiazolone methoxy acrylate derivative IV to the anti-plant virus agent is 1% by mass: 99% to 99%: 1% by mass;

优选地，所述抗病毒组合物加工的剂型选自：种子处理乳剂、水乳剂、微乳剂、悬乳剂、胶囊悬浮剂、水溶性粒剂、细粒剂、可溶性浓剂、毒谷、块状毒饵、粒状毒饵、片状毒饵、浓毒饵、缓释块、静电喷雾剂、水包油乳剂、烟雾罐、烟雾烛、烟雾筒、烟雾棒、烟雾片、烟雾丸、发气剂、油膏、热雾剂、冷雾剂、气雾剂、固/液混合装剂、液/液混合装剂、固/固混合装剂、药漆、微粒剂、追踪粉剂、油悬剂、油分散性粉剂、浓胶剂、泼浇剂、种衣剂、涂抹剂、成膜油剂、超低容量液剂、蒸汽释放剂；Preferably, the antiviral composition is processed in a dosage form selected from the group consisting of: seed treatment emulsion, water emulsion, microemulsion, suspoemulsion, capsule suspension, water-soluble granule, fine granule, soluble concentrate, poisonous valley, lumps Poison baits, granular baits, flake baits, concentrated baits, slow release blocks, electrostatic sprays, oil-in-water emulsions, smoke cans, smoke candles, smoke tubes, smoke sticks, Smoke tablets, smoke pills, gas generators, ointments, hot sprays, cold sprays, aerosols, solid/liquid mixed agents, liquid/liquid mixed agents, solid/solid mixed agents, paints, particles Agent, trace powder, oil suspension, oil dispersible powder, thick glue, pouring agent, seed coating agent, smear agent, film forming oil agent, ultra low volume liquid agent, steam release agent;

优选地，所述抗病毒组合物防治的病毒病害选自：水稻矮缩病、黄矮病、条纹叶枯病、番茄蕨叶病毒病、辣椒花叶病毒病、烟草脉坏死病毒病、玉米矮花叶病、花椰菜花叶病毒、柑橘病毒病、建兰花叶病毒、建兰环斑病毒；Preferably, the viral disease controlled by the antiviral composition is selected from the group consisting of rice dwarf disease, yellow dwarf disease, stripe leaf blight, tomato fern leaf virus disease, pepper mosaic virus disease, tobacco vein necrosis virus disease, corn dwarf Mosaic disease, cauliflower mosaic virus, citrus virus disease, broccoli virus, Jianlan ring spot virus;

优选地，所述抗病毒组合物用于防治的植物选自：稻谷、小麦、大麦、燕麦、玉米、高粱、甘薯、马铃薯、木薯、大豆、荷兰豆、蚕豆、豌豆、绿豆、小豆、棉花、蚕桑、花生、油菜、芝麻、向日葵、甜菜、甘蔗、咖啡、可可、人参、贝母、橡胶、椰子、油棕、剑麻、烟草、番茄、辣椒、萝卜、黄瓜、白菜、芹菜、榨菜、甜菜、油菜、葱、大蒜、西瓜、甜瓜、哈密瓜、木瓜、苹果、柑桔和桃树、茶、山野菜、竹笋、啤酒花、胡椒、香蕉、番木瓜、兰花、盆景。Preferably, the plant for controlling the antiviral composition is selected from the group consisting of: rice, wheat, barley, oats, corn, sorghum, sweet potato, potato, tapioca, soybean, pea, broad bean, pea, mung bean, adzuki bean, cotton, sericulture , peanuts, rapeseed, sesame, sunflower, beet, sugar cane, coffee, cocoa, ginseng, fritillary, rubber, coconut, oil palm, sisal, tobacco, tomato, pepper, radish, cucumber, cabbage, celery, mustard, beet, Rape, onion, garlic, watermelon, melon, cantaloupe, papaya, apple, citrus and peach, tea, wild vegetables, bamboo shoots, hops, pepper, banana, papaya, orchid, bonsai.

优选地，所述的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ与所述杀螨剂中的任意一种或两种组合形成杀螨组合物用于防治农业和林业以及园艺植物螨害；Preferably, the thiadiazolone methoxy acrylate derivative IV is combined with any one or both of the acaricides to form a miticide composition for controlling agricultural and forestry and horticultural plant damage. ;

优选地，所述杀螨剂选自：***锡、三环锡、苯丁锡、三磷锡、毒虫畏、甲基毒虫畏、巴毒磷、敌敌畏、庚烯磷、速灭磷、久效磷、二溴磷、毒死蜱、嘧啶磷、氯甲亚胺硫磷、氧乐果、敌杀磷、乙硫磷、马拉硫磷、虫螨畏、伏杀硫磷、辛硫磷、甲基嘧啶硫磷、喹硫磷、治螟磷、***磷、蚜灭多、水胺硫磷、甲胺磷、胺丙畏、氯亚胺硫磷、亚胺硫磷、氟丙菊酯、联苯菊酯、氯氟氰菊酯、精高效氯氟氰菊酯、甲氰菊酯、氟氰戊菊酯、氟氯苯菊酯、氟胺氰菊酯、溴氟菊酯、联苯肼酯、苯硫威、涕灭威、丁酮威、杀线威、抗虫威、久效威、苯菌灵、氯灭杀威、克百威、丁硫克百威、速灭威、蜱虱威、伐虫脒、单甲脒、杀螨脒、双甲脒、杀虫脒、苯甲酸苄酯、溴螨酯、丁氟螨酯、灭螨醌、氟蚜螨、氟虫脲、浏阳霉素、虫螨霉素、苏云金素、杀螨素、浏阳霉素、阿维菌素、多拉菌素、埃普利诺菌素、伊维菌素、赛拉菌素、莫西菌素、除虫菊素、烟碱、苦参碱、印楝素、鱼藤酮、吡螨胺、哒螨酮、唑螨酯、四螨嗪、炔螨特、噻螨酮、螺螨酯、嘧螨酯、杀螨酯、克螨特、哒螨灵；Preferably, the acaricide is selected from the group consisting of: triazole tin, tricyclotin, phenbutyltin, triphosphorus, chlorpyrifos, methyl chlorpyrifos, phytophos, dichlorvos, heptene phosphorus, quick-killing phosphorus, long time Phosphorus, dibromophosphorus, chlorpyrifos, pyrimidine, chloromethylimine, omethoate, chlorpyrifos, ethion, malathion, worm, phoxim, phoxim, Pyrithione, quetiapine, strontium phosphate, triazophos, quenching, acesulfame, methamidophos, acesulfame, chloroimidate, imipenem, flumethrin, Bifenthrin, cyhalothrin, cyhalothrin, fenpropathrin, fluvalerate, flumethrin, fluvalinate, bifenthrin, biphenyl hydrazine Ester, phenylthiocarb, aldicarb, butanone, chlorpyrifos, anti-insect, long-acting, benomyl, chlorhexidine, carbofuran, butyl thiocarb, fast-acting, 蜱Converse, worm, monomethyl hydrazine, acaricidal, amitraz, chlorpyrifos, benzyl benzoate, bromo oxime ester, butyl fluoro ester, guanidine, fluoranthene, flubenzuron, Liuyang Neomycin, echinomycin, sulphate, acaricidin, liuyangmycin Avermectin, doramectin, eplenomycin, ivermectin, serramycin, moxidectin, pyrethrin, nicotine, matrine, azadirachtin, rotenone, pyridoxine Amine, anthrone, oxazolidine, tetrazine, alkyne, thiazolone, spirodecyl ester, pyridoxine, acaricidal ester, ketone, hydrazine;

优选地，所述的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ在所述杀螨组合物中的总的质量百分含量是1％-90％；Preferably, the total mass percentage of the thiadiazolone methoxy acrylate derivative IV in the acaricidal composition is from 1% to 90%;

优选地，所述的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ与所述杀螨剂的比例为质量百分比1％∶99％到99％∶1％； Preferably, the ratio of the thiadiazolone methoxy acrylate derivative IV to the acaricide is 1% by mass: 99% to 99%: 1% by mass;

优选地，所述杀螨组合物加工的剂型选自：种子处理乳剂、水乳剂、微乳剂、悬乳剂、胶囊悬浮剂、水溶性粒剂、细粒剂、可溶性浓剂、毒谷、块状毒饵、粒状毒饵、片状毒饵、浓毒饵、缓释块、静电喷雾剂、水包油乳剂、烟雾罐、烟雾烛、烟雾筒、烟雾棒、烟雾片、烟雾丸、发气剂、油膏、热雾剂、冷雾剂、气雾剂、固/液混合装剂、液/液混合装剂、固/固混合装剂、药漆、微粒剂、追踪粉剂、油悬剂、油分散性粉剂、浓胶剂、泼浇剂、种衣剂、涂抹剂、成膜油剂、超低容量液剂、蒸汽释放剂；Preferably, the dosage form processed by the acaricidal composition is selected from the group consisting of: seed treatment emulsion, water emulsion, microemulsion, suspoemulsion, capsule suspension, water-soluble granule, fine granule, soluble concentrate, poisonous valley, block Bait, granular bait, flake bait, concentrated bait, slow release block, electrostatic spray, oil-in-water emulsion, smoke can, smoke candle, smoke tube, smoke stick, smoke sheet, smoke pill, gas generator, ointment, Hot mist, cold spray, aerosol, solid/liquid mixed charge, liquid/liquid mixed charge, solid/solid mixed charge, lacquer, microparticle, trace powder, oil suspension, oil dispersible powder , thickener, pouring agent, seed coating agent, smear agent, film forming oil agent, ultra low volume liquid agent, steam release agent;

优选地，所述杀螨组合物防治的螨害选自：螨害选自叶螨科、细须螨科、呋线螨、瘿螨科、红叶螨属、瘿螨科的害螨，这些害螨是世界性农业害螨、林业害螨、园艺害螨和卫生害螨；Preferably, the cockroach damage controlled by the acaricidal composition is selected from the group consisting of: the mites are selected from the group consisting of the genus Aphididae, the genus Diptera, the eucalyptus, the genus Eucalyptus, the genus Eucalyptus, and the mites. World agricultural pests, forest pests, horticultural pests and health hazards;

优选地，所述杀螨组合物用于防治的植物选自：稻谷、小麦、大麦、燕麦、玉米、高粱、甘薯、马铃薯、木薯、大豆、荷兰豆、蚕豆、豌豆、绿豆、小豆、棉花、蚕桑、花生、油菜、芝麻、向日葵、甜菜、甘蔗、咖啡、可可、人参、贝母、橡胶、椰子、油棕、剑麻、烟草、番茄、辣椒、萝卜、黄瓜、白菜、芹菜、榨菜、甜菜、油菜、葱、大蒜、西瓜、甜瓜、哈密瓜、木瓜、苹果、柑桔和桃树、茶、山野菜、竹笋、啤酒花、胡椒、香蕉、番木瓜、兰花、盆景。Preferably, the plant for controlling the acaricidal composition is selected from the group consisting of: rice, wheat, barley, oats, corn, sorghum, sweet potato, potato, cassava, soybean, pea, broad bean, pea, mung bean, adzuki bean, cotton, sericulture , peanuts, rapeseed, sesame, sunflower, beet, sugar cane, coffee, cocoa, ginseng, fritillary, rubber, coconut, oil palm, sisal, tobacco, tomato, pepper, radish, cucumber, cabbage, celery, mustard, beet, Rape, onion, garlic, watermelon, melon, cantaloupe, papaya, apple, citrus and peach, tea, wild vegetables, bamboo shoots, hops, pepper, banana, papaya, orchid, bonsai.

本发明所述的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ的生物活性测定如下：The biological activity of the thiadiazolone methoxy acrylate derivative IV of the present invention is determined as follows:

D.本发明的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ的杀菌活性测定：D. Determination of bactericidal activity of the thiadiazolyl ether methoxy acrylate derivative IV of the present invention:

本发明的噻二唑肟醚甲氧基丙烯酸酯Ⅳ的杀菌或抑菌活性采用菌体生长率测定法，具体步骤为：取1.8毫克样品溶解在2滴N,N-二甲基甲酰胺中，然后用含有一定量吐温20乳化剂的水溶液稀释至500微克/毫升的药剂，将供试药剂在无菌条件下各吸取1毫升于培养皿内，再分别加入9毫升PDA培养基，摇匀后制成50微克/毫升含药平板，以添加1毫升灭菌水的平板做空白对照，用直径4毫米的打孔器沿菌丝外缘切取菌盘，移至含药平板上，呈等边三角形摆放，每处理重复3次，将培养皿放在24±1摄氏度恒温培养箱内培养，待对照菌落直径扩展到2-3厘米后调查各处理菌盘扩展直径，求平均值，与空白对照比较计算相对抑菌率，供试菌种为我国农业生产中田间实际发生的大部分典型植物病原菌的种属，其代号和名称如下：AS：番茄早疫病菌，其拉丁名为：Alternaria solani、BC：黄瓜灰霉病菌，其拉丁名为：Botrytis cinerea、CA：花生褐斑病菌，其拉丁名为：Cercospora arachidicola、GZ：小麦赤霉病菌，其拉丁名为：Gibberella zeae、PI：马铃薯晚疫病菌，其拉丁名为：Phytophthora infestans(Mont.)de Bary、PP：苹果轮纹病菌，其拉丁名为：Physalospora piricola、PS：水稻纹枯病菌，其拉丁名为：Pellicularia sasakii、RC：禾谷丝核菌，其拉丁名为：Rhizoctonia cerealis、SS：油菜菌核病菌，其拉丁名为：Sclerotinia sclerotiorum。 The bactericidal or bacteriostatic activity of the thiadiazolone methoxy acrylate IV of the present invention is determined by the growth rate of the cells, and the specific steps are as follows: a sample of 1.8 mg is dissolved in 2 drops of N,N-dimethylformamide. Then, the agent is diluted to 500 μg/ml with an aqueous solution containing a certain amount of Tween 20 emulsifier, and 1 ml of each test sample is aspirated under sterile conditions, and then 9 ml of PDA medium is added separately, and shaken. After homogenization, a 50 μg/ml drug-containing plate was prepared, and a plate with 1 ml of sterilized water was added as a blank control. The bacteria disk was cut along the outer edge of the hyphae with a 4 mm diameter puncher and transferred to the drug-containing plate. The equilateral triangle was placed and the treatment was repeated 3 times. The culture dish was placed in a constant temperature incubator at 24 ± 1 ° C. After the diameter of the control colony was extended to 2-3 cm, the expanded diameter of each treated dish was investigated and averaged. Compared with the blank control, the relative inhibition rate was calculated. The tested strains were the species of most typical plant pathogens actually occurring in the field of agricultural production in China. The codes and names are as follows: AS: tomato early blight, its Latin name: Alternaria solani, BC: Cucumber gray mold, its Latin name: Botrytis cinerea, CA: peanut brown spot disease, its Latin name: Cercospora arachidicola, GZ: Fusarium graminearum, its Latin name: Gibberella zeae, PI: Phytophthora infestans, Its Latin name is: Phytophthora infestans (Mont.) de Bary, PP: Apple ring rot, its Latin name: Physalospora piricola, PS: Rhizoctonia solani, its Latin name: Pellicularia sasakii, RC: cereal Nuclear bacteria, its Latin name: Rhizoctonia cerealis, SS: Sclerotinia sclerotiorum, its Latin name: Sclerotinia sclerotiorum.

E.本发明的3,4-二氯噻二唑肟醚甲氧基丙烯酸酯衍生物诱导抗病活性的测定：E. Determination of Induced Disease Resistance Activity of 3,4-Dichlorothiadiazolyl Ether methoxyacrylate Derivatives of the Invention:

噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ的活性筛选方法如下，烟草花叶病毒简写为TMV：The screening method for the activity of the thiadiazolyl ether methoxy acrylate derivative IV is as follows. The tobacco mosaic virus is abbreviated as TMV:

(1).阳性对照植物激活剂：选择质量纯度纯度大于99.5％的噻酰菌胺为阳性对照的植物激活剂；噻酰菌胺简写为TDL；(1). Positive control plant activator: select a plant activator with a purity purity greater than 99.5% of thiazide as a positive control; thiazide is abbreviated as TDL;

(2).噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ的诱导烟草抗TMV活性的筛选方法：离体直接抗病毒活性的测定采用半叶法进行；活体诱导是将苗龄一致的普通烟，3盆为一组，分别于接种前7天前处理过的烟苗，处理方式包括：喷施供试化合物溶液2到3次，每次10毫升，或土壤处理，每次10毫升，测定浓度为100微克/毫升，第7天于新长出的烟叶上摩擦接种TMV，将烟苗置于其生长适宜温度及光照下培养3天后，检查发病情况，综合病斑数目按下式计算出供试化合物对TMV的诱导抗病毒效果，每一处理设3次重复，空白对照和标准药剂对照分别选择水和TDL：(2). Screening method for inducing tobacco anti-TMV activity of thiadiazolone methoxy acrylate derivative IV: The determination of direct antiviral activity in vitro is carried out by the half-leaf method; the in vivo induction is common for the age of the seedlings. Smoke, 3 pots, a group of tobacco seedlings treated 7 days before inoculation, including: spraying the test compound solution 2 to 3 times, each 10 ml, or soil treatment, 10 ml each time, The concentration was determined to be 100 μg/ml. On the 7th day, TMV was inoculated on the newly grown tobacco leaves, and the tobacco seedlings were placed in the growth temperature and light for 3 days. The disease was examined and the number of lesions was calculated according to the following formula. The induced antiviral effect of the test compound on TMV was determined, and each treatment was repeated 3 times. The blank control and the standard drug control were respectively selected for water and TDL:

其中，R为供试化合物对烟草抗TMV的诱导效果，单位：％；CK为清水对照叶片的平均枯斑数，单位：个；I为经供试化合物诱导处理后叶片的平均枯斑数，单位：个。Wherein, R is the inducing effect of the test compound on tobacco anti-TMV, unit: %; CK is the average number of dead spots of the control leaves of clear water, unit: one; I is the average number of leaves of the leaves after induction treatment by the test compound, unit: PCS.

本发明的有益效果是：对噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ进行了先导优化，并对噻二唑肟醚甲氧基丙烯酸酯衍生物进行了抑菌活性的筛选。The invention has the beneficial effects of optimizing the thiadiazolyl ether methoxy acrylate derivative IV and screening the thiadiazolyl ether methoxy acrylate derivative for antibacterial activity.

本发明通过特定制备和生物活性测定实施例更加具体说明噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ的合成与生物活性及应用，所述实施例仅用于具体说明本发明而非限制本发明，尤其是生物活性仅是举例说明，而非限制本专利，具体实施方式如下：The present invention more specifically illustrates the synthesis and biological activity and application of the thiadiazolone methoxy acrylate derivative IV by specific preparation and biological activity assay examples, which are intended to specifically illustrate the invention and not to limit it. The invention, and in particular the biological activity, is merely illustrative and not limiting, and the specific embodiments are as follows:

实施例1：化合物Ⅱ的制备：Example 1: Preparation of Compound II:

在25毫升单口圆底烧瓶中加入1.10毫摩尔化合物I，用15毫升乙醇溶解，再加入1.00毫摩尔取代1,2,3-噻二唑羰基化合物，所述1,2,3-噻二唑羰基化合物选自：4-甲基-1,2,3-噻二唑-5-甲醛、4-甲基-1,2,3-噻二唑-5-乙酮、5-甲基-1,2,3-噻二唑-4-甲醛、5-甲基-1,2,3-噻二唑-4-乙酮，最后反应体系中滴加两滴2摩尔/升的盐酸，室温搅拌12小时，反应完全后减压除去溶剂，残余物经200～300目硅胶柱层析纯化得化合物Ⅱ，洗脱剂为60～90摄氏度的石油醚:乙酸乙酯，体积比为9:1，收率70-80％；当R¹为甲基，Z为氮时，该化合物的核磁数据如下：¹HNMR(CDCl₃)δ7.51(s,1H,Ph-H),7.47-7.43(m,2H,Ph-H),7.24-7.20(m,1H,Ph-H),5.23(s,2H,Ph-CH₂),4.06(s,3H,O-CH₃),3.83(s,3H,O-CH₃),2.52(s,3H,N＝C-CH₃)。化合物Ⅲ制备的量和反应容器的体积按相应比例扩大或缩小。化合物Ⅱ的理化参数和结构参数见表1。Into a 25 ml single-neck round bottom flask, 1.10 mmol of Compound I was added, dissolved in 15 ml of ethanol, and then 1.00 mmol of a substituted 1,2,3-thiadiazole carbonyl compound, 1,2,3-thiadiazole, was added. The carbonyl compound is selected from the group consisting of: 4-methyl-1,2,3-thiadiazol-5-carboxaldehyde, 4-methyl-1,2,3-thiadiazol-5-ethanone, 5-methyl-1 , 2,3-thiadiazole-4-carbaldehyde, 5-methyl-1,2,3-thiadiazole-4-ethyl ketone, two drops of 2 mol/L hydrochloric acid were added dropwise in the final reaction system, and stirred at room temperature. After the reaction was completed, the solvent was removed under reduced pressure. The residue was purified by silica gel column chromatography from 200 to 300 mesh to afford compound II, eluent: petroleum ether: ethyl acetate of 60 to 90 ° C, with a volume ratio of 9:1. The yield is 70-80%; when R ¹ is methyl and Z is nitrogen, the nuclear magnetic data of the compound is as follows: ¹ H NMR (CDCl ₃ ) δ 7.51 (s, 1H, Ph-H), 7.47-7.43 (m) , 2H, Ph-H), 7.24-7.20 (m, 1H, Ph-H), 5.23 (s, 2H, Ph-CH ₂ ), 4.06 (s, 3H, O-CH ₃ ), 3.83 (s, 3H) , O-CH ₃ ), 2.52 (s, 3H, N = C-CH ₃ ). The amount of Compound III prepared and the volume of the reaction vessel are expanded or reduced in proportions. The physical and chemical parameters and structural parameters of Compound II are shown in Table 1.

实施例2：化合物Ⅲ的制备： Example 2: Preparation of Compound III:

在25毫升单口圆底烧瓶中加入0.24毫摩尔化合物Ⅱ，用15毫升甲醇溶解，向反应中加入0.03克，即0.72毫摩尔氢氧化钠，然后加热回流30分钟，反应结束后将反应液浓缩，残余物用10毫升乙酸乙酯稀释，加入10毫升的水将固体全部溶解，分离出水层，水层用2摩尔/升的盐酸调节pH至3，然后用乙酸乙酯萃取，水层用乙酸乙酯反萃一遍，合并有机层，有机层用饱和氯化钠洗一遍，无水硫酸钠干燥，抽滤，减压除去溶剂，得化合物Ⅲ；收率95-100％；化合物Ⅲ制备的量和反应容器的体积按相应比例扩大或缩小。化合物Ⅲ的理化参数和结构参数见表1。To a 25 ml single-necked round bottom flask was added 0.24 mmol of Compound II, dissolved in 15 ml of methanol, and 0.03 g of 0.72 mmol of sodium hydroxide was added to the reaction, followed by heating under reflux for 30 minutes. After the reaction was completed, the reaction mixture was concentrated. The residue was diluted with 10 ml of ethyl acetate. The solid was completely dissolved by adding 10 ml of water. The aqueous layer was separated. The aqueous layer was adjusted to pH 3 with 2 mol/L hydrochloric acid, and then extracted with ethyl acetate. The ester was back-extracted, and the organic layer was combined. The organic layer was washed with saturated sodium chloride and dried over anhydrous sodium sulfate, filtered, and then evaporated to remove solvent to afford compound III; yield 95-100%; The volume of the reaction vessel is enlarged or reduced in proportion to the corresponding ratio. The physical and chemical parameters and structural parameters of Compound III are shown in Table 1.

实施例3：化合物Ⅳ的制备：Example 3: Preparation of Compound IV:

在25毫升单口圆底烧瓶中加入0.30毫摩尔化合物Ⅲ，用15毫升干燥的二氯甲烷溶解，向反应中加入0.69克，即0.36毫摩尔的EDCI，即1-乙基-(3-二甲基氨基丙基)碳二亚胺盐酸盐和0.43克，即0.32毫摩尔的HOBT，即1-羟基苯并三氮唑，加完之后室温搅拌30分钟，然后向反应体系中加入0.32毫摩尔的R³-XH_n，n＝1,2；室温搅拌2小时，反应结束后，反应液用15毫升的水洗两遍，分离出有机层，有机层分别用饱和碳酸氢钠和饱和氯化钠各洗一遍，无水硫酸钠干燥，抽滤，减压除去溶剂，残余物经200～300目硅胶柱层析纯化得白色固体Ⅳ，洗脱剂为60～90摄氏度的石油醚:乙酸乙酯，体积比为4:1，收率69％；当R¹为4-甲基-1,2,3-噻二唑-5-基，R²为甲基，R³为环丙基，X为氮，Z为氮时，该化合物的核磁数据如下：δ7.41-7.29(m,3H,Ph-H),7.12(d,J＝7.1Hz,1H,Ph-H),6.80(s,1H,O＝C-NH),5.06(s,2H,Ph-CH₂),3.87(s,3H,O-CH₃),2.72(d,J＝3.3Hz,1H,N-CH),2.68(s,3H,thiadiazole-CH₃),2.20(s,3H,N＝C-CH₃),0.74(d,J＝6.8Hz,2H,cyclopropyl-CH₂),0.51(s,2H,cyclopropyl-CH₂)。化合物Ⅳ制备的量和反应容器的体积按相应比例扩大或缩小。化合物Ⅳ的理化参数和结构参数见表1。To a 25 ml single-neck round bottom flask was added 0.30 mmol of compound III, dissolved in 15 ml of dry dichloromethane, and 0.69 g, ie 0.36 mmol of EDCI, ie 1-ethyl-(3-dimethyl) was added to the reaction. Base aminopropyl) carbodiimide hydrochloride and 0.43 g, ie 0.32 mmol of HOBT, ie 1-hydroxybenzotriazole, after stirring at room temperature for 30 minutes, then adding 0.32 mmol to the reaction system R ³ -XH _n , n = 1, 2; stirring at room temperature for 2 hours, after the reaction is completed, the reaction solution is washed twice with 15 ml of water, and the organic layer is separated, and the organic layer is respectively saturated sodium hydrogen carbonate and saturated sodium chloride Each was washed once, dried over anhydrous sodium sulfate, suction filtered, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography from 200 to 300 mesh to afford white solid IV, e. , the volume ratio is 4:1, the yield is 69%; when R ¹ is 4-methyl-1,2,3-thiadiazol-5-yl, R ² is methyl, R ³ is cyclopropyl, X When nitrogen is nitrogen and Z is nitrogen, the nuclear magnetic data of the compound are as follows: δ 7.41-7.29 (m, 3H, Ph-H), 7.12 (d, J = 7.1 Hz, 1H, Ph-H), 6.80 (s, 1H, O=C-NH), 5.06 (s, 2H, Ph-CH ₂ ), 3.87 (s, 3H, O-CH ₃ ), 2.72 (d, J = 3.3 Hz, 1H, N-CH), 2.68 (s, 3H, thiadiazole-CH ₃ ), 2.20 (s, 3H, N = C-CH ₃ ), 0.74 ( d, J = 6.8 Hz, 2H, cyclopropyl-CH ₂ ), 0.51 (s, 2H, cyclopropyl-CH ₂ ). The amount of Compound IV prepared and the volume of the reaction vessel are enlarged or reduced in corresponding proportions. The physical and chemical parameters and structural parameters of compound IV are shown in Table 1.

实施例4：化合物CL04-00的制备方法：Example 4: Preparation of Compound CL04-00:

在25毫升单口圆底烧瓶中加入1.10毫摩尔化合物b，用15毫升乙醇溶解，再加入1.00毫摩尔3-氯异噻唑-5-乙酮，最后反应体系中滴加两滴2摩尔/升的盐酸，室温搅拌12小时，反应完全后减压除去溶剂，残余物经200～300目硅胶柱层析纯化得化合物CL04-00，洗脱剂为60～90摄氏度的石油醚:乙酸乙酯，体积比为4:1，收率68.22％。In a 25 ml single-neck round bottom flask, 1.10 mmol of compound b was added, dissolved in 15 ml of ethanol, and then 1.00 mmol of 3-chloroisothiazol-5-ethanone was added. Finally, two drops of 2 mol/L were added to the reaction system. Hydrochloric acid, stirred at room temperature for 12 hours, the reaction was completed, the solvent was removed under reduced pressure, and the residue was purified by silica gel column chromatography from 200 to 300 mesh to obtain compound CL04-00, eluent: petroleum ether: ethyl acetate, 60-90 ° C, volume The ratio was 4:1 and the yield was 68.22%.

实施例5：本发明的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ的抑菌活性测定结果：Example 5: Determination of antibacterial activity of the thiadiazolyl ether methoxy acrylate derivative IV of the present invention:

本发明测试的常见植物病原真菌的代号和名称如下：AS：番茄早疫病菌，其拉丁名为：Alternaria solani、BC：黄瓜灰霉病菌，其拉丁名为：Botrytis cinerea、CA：花生褐斑病菌，其拉丁名为：Cercospora arachidicola、GZ：小麦赤霉病菌，其拉丁名为：Gibberella zeae、PI：马铃薯晚疫病菌，其拉丁名为：Phytophthora infestans(Mont.)de Bary、PP：苹果轮纹病菌，其拉丁名为：Physalospora piricola、PS：水稻纹枯病菌，其拉丁名为：Pellicularia sasakii、RC：禾谷丝核菌，其拉丁名为：Rhizoctonia cerealis、SS：油菜菌核病菌，其拉丁名为：Sclerotinia sclerotiorum，这些菌种具有很好的代表性，能够代表农业生产中田间发生的大部分病原菌的种属。The code and name of the common phytopathogenic fungi tested in the present invention are as follows: AS: tomato Phytophthora infestans, Latin name: Alternaria solani, BC: Botrytis cinerea, Latin name: Botrytis cinerea, CA: Peanut brown spot disease Its Latin name: Cercospora arachidicola, GZ: Fusarium graminearum, its Latin name: Gibberella zeae, PI: Phytophthora infestans, Latin name: Phytophthora infestans (Mont.) de Bary, PP: Apple wheel The pathogen, its Latin name: Physalospora piricola, PS: Rhizoctonia solani, its Latin name: Pellicularia sasakii, RC: Rhizoctonia cereal, its Latin name: Rhizoctonia cerealis, SS: Sclerotinia sclerotiorum, its The Latin name is: Sclerotinia sclerotiorum, which is well-represented and represents the species of most pathogens that occur in the field of agricultural production.

值得注意的是本发明中化合物CL04-00为专利WO 2000003974A1中报道过的化学结构与本发明目标化合物最接近的已知化合物，为了比较本发明合成的新化合物的生物活性，本发明合成了结构最接近本发明目标化合物的已知化合物CL04-00作为对照化合物，并与本发明目标化合物进行活性比较。It is to be noted that the compound CL04-00 in the present invention is a known compound whose chemical structure is reported closest to the target compound of the present invention as reported in the patent WO 2000003974 A1. In order to compare the biological activity of the novel compound synthesized by the present invention, the present invention synthesizes the structure. The known compound CL04-00 closest to the target compound of the present invention is used as a control compound and compared with the activity of the target compound of the present invention.

菌体生长率法测定结果见表2，表2表明，在50微克/毫升时，本发明合成的所有化合物均有不同程度的杀菌活性。对于番茄早疫病菌而言，本发明的化合物CL04-35E、CL04-29-1、CL04-29-2、CL04-30D、CL04-35B、CL04-35D、CL04-35A、Gxf01-43A、Znl01-19E的抑制率达到30％以上，上述化合物的杀菌活性均高出文献报道的与本发明目标化合物化学结构最接近的化合物CL04-0010％以上，其中化合物CL04-35B的杀菌活性达到60％，高出对照药烯肟菌酯10％以上；对于花生褐斑病菌而言，化合物CL04-35E、CL04-29-1、CL04-29-2、Gxf01-45、CL04-30C、CL04-30D、CL04-35B、CL04-35D、CL04-35A、Gxf01-43A和Znl01-19E的杀菌活性均在30％以上，上述化合物的杀菌活性均高出文献报道的与本发明目标化合物化学结构最接近的化合物CL04-0010％以上,其中化合物CL04-29-1、CL04-29-2、CL04-35B、CL04-35D、CL04-35A和Gxf01-43A的杀菌活性均在60％以上，均高出对照药嘧菌酯和烯肟菌酯10％以上，其中化合物CL04-29-1、CL04-29-2和CL04-35B的抑制率达到75％以上，且化合物CL04-29-1和CL04-29-2抑制率最高，达78.57％；对于小麦赤霉病菌的活性表明，化合物CL04-35E、CL04-29-1、CL04-29-2、Gxf01-45、CL04-30A、CL04-30B、CL04-30C、CL04-30D、CL04-30E、CL04-35B、CL04-35D、CL04-35A、Gxf01-43A、Znl01-19C、Znl01-19A、Znl01-19B、Znl01-19E和Znl01-19D的抑制率均在50％以上，上述化合物的杀菌活性均高出文献报道的与本发明目标化合物化学结构最接近的化合物CL04-0010％以上,和对照药烯肟菌酯30％以上，其中化合物CL04-29-1、CL04-29-2、CL04-30B、CL04-30D、CL04-35B、CL04-35A、Gxf01-43A的抑制率均在80％以上，均高出对照药嘧菌酯10％以上，尤其化合物CL04-29-1、CL04-30B、CL04-35B和CL04-35的杀菌活性最高，达100％；对苹果轮纹病菌而言，化合物CL04-35E、CL04-29-1、Gxf01-45、CL04-30C、CL04-30D、CL04-30E、CL04-30F、CL04-35B、CL04-35D、CL04-35A、Znl01-19B和Znl01-19E的抑制率均在40％以上，其中化合物CL04-30C、CL04-35B和CL04-35A的杀菌活性均高出文献报道的与本发明目标化合物化学结构最接近的化合物CL04-0010％以上，且化合物CL04-35B的抑制率最高，达61.40％，高于对照药烯肟菌酯；对于黄瓜灰霉病菌而言，化合物CL04-35E、CL04-29-1、CL04-29-2、CL04-30C、CL04-30D、CL04-30F、CL04-35B、CL04-35D、CL04-35A、 Gxf01-43A、Znl01-19E和Znl01-19D的抑制率均在40％以上，其中化合物CL04-35E、CL04-29-1、CL04-29-2、CL04-30C、CL04-30D、CL04-35B、CL04-35D、CL04-35A、Gxf01-43A和Znl01-19D的杀菌活性均高出文献报道的与本发明目标化合物化学结构最接近的化合物CL04-0010％以上，且化合物CL04-29-1、CL04-29-2、CL04-35B、CL04-35D、CL04-35A和Gxf01-43A的抑制率均在60％以上，均高出对照药烯肟菌酯10％以上，化合物CL04-29-1、CL04-35B和CL04-35A的抑制率均在80％以上，尤其化合物CL04-35B和CL04-35A的杀菌活性最高，达100％，高于对照药嘧菌酯；对于油菜菌核病菌而言，化合物CL04-35E、CL04-29-1、CL04-29-2、Gxf01-45、CL04-30A、CL04-30B、CL04-30C、CL04-30D、CL04-30E、CL04-30F、CL04-35B、CL04-35D、CL04-35A、Gxf01-43A、Znl01-19C、Znl01-19A、Znl01-19B、Znl01-19E、Znl01-19D、Znl01-19F的杀菌活性均在30％以上，上述化合物的杀菌活性均高出文献报道的与本发明目标化合物化学结构最接近的化合物CL04-0010％以上，其中化合物CL04-35E、CL04-29-1、CL04-29-2、Gxf01-45、CL04-30B、CL04-30D、CL04-30E、CL04-30F、CL04-35B、CL04-35D、CL04-35A、Gxf01-43A、Znl01-19E的杀菌活性均在60％以上，均高出对照药烯肟菌酯15％以上，其中化合物CL04-29-1、CL04-29-2和Gxf01-43A的抑制率均在90％以上，均高出对照药嘧菌酯10％以上，且化合物CL04-29-1和Gxf01-43A的抑制率最高，达100％；对于禾谷丝核菌而言，化合物CL04-35E、CL04-29-1、CL04-29-2、Gxf01-45、CL04-30B、CL04-30C、CL04-30D、CL04-30E、CL04-30F、CL04-35B、CL04-35D、CL04-35A、Gxf01-43A、Znl01-19E和Znl01-19D的杀菌活性均在60％以上，上述化合物的杀菌活性均高出文献报道的与本发明目标化合物化学结构最接近的化合物CL04-0040％以上，其中化合物CL04-29-1、CL04-29-2、CL04-30B、CL04-30C、CL04-30E、CL04-35B、CL04-35D、CL04-35A、Gxf01-43A和Znl01-19E的杀菌活性均在80％以上，且化合物CL04-29-1、CL04-30B、CL04-35B、CL04-35D、CL04-35A、Gxf01-43A和Znl01-19E杀菌活性均高出对照药烯肟菌酯10％以上，尤其是化合物CL04-35D、CL04-35A、Gxf01-43A和Znl01-19E的杀菌活性最高，达100％，高出对照药嘧菌酯15％以上；对水稻纹枯病菌的活性表明，化合物CL04-35E、CL04-30B、CL04-30C、CL04-30D、CL04-35B、CL04-35D、CL04-35A、Gxf01-43A和Znl01-19E的杀菌活性均在30％以上，上述化合物的杀菌活性均高出文献报道的与本发明目标化合物化学结构最接近的化合物CL04-0010％以上，其中化合物CL04-30B、CL04-30D、CL04-35A、Gxf01-43A和Znl01-19E的杀菌活性均在60％以上，且化合物CL04-30D、CL04-35A、Gxf01-43A和Znl01-19E的杀菌活性均高出对照药烯肟菌酯10％以上，尤其化合物CL04-30D的杀菌活性最高，达89.19％，高于对照药嘧菌酯；对于马铃薯晚疫病菌而言，化合物CL04-35E、CL04-29-1、CL04-29-2、Gxf01-45、CL04-30B、CL04-30C、CL04-30D、CL04-30E、CL04-30F、CL04-35B、CL04-35D、CL04-35A、Gxf01-43A、Znl01-19A和Znl01-19E的杀菌活性均在60％以上，上述化合物的杀菌活性均高出文献报道的与本发明目标化合物化学结构最接近的化合物CL04-00、烯肟菌酯20％以上和对照药嘧菌酯10％以上，其中化合物CL04-35E、CL04-30B、CL04-30C、CL04-30D、CL04-35B、CL04-35D、CL04-35A、Gxf01-43A、Znl01-19A和Znl01-19E的杀菌活性高达100％；综上可得化合物CL04-35A具有广谱的杀菌活性。The results of the cell growth rate assay are shown in Table 2. Table 2 shows that at 50 μg/ml, all of the compounds synthesized in the present invention have different degrees of bactericidal activity. For the tomato Phytophthora infestans, the compounds of the invention CL04-35E, CL04-29-1, CL04-29-2, CL04-30D, CL04-35B, CL04-35D, CL04-35A, Gxf01-43A, Znl01- The inhibition rate of 19E is more than 30%, and the bactericidal activity of the above compound is higher than that of the compound CL04-0010% which is the closest to the chemical structure of the target compound of the present invention reported in the literature, wherein the bactericidal activity of the compound CL04-35B is 60%, high. More than 10% of the reference drug enestrobin; for the peanut brown spot disease, compounds CL04-35E, CL04-29-1, CL04-29-2, Gxf01-45, CL04-30C, CL04-30D, CL04- The bactericidal activities of 35B, CL04-35D, CL04-35A, Gxf01-43A and Znl01-19E were all above 30%. The bactericidal activity of the above compounds was higher than that reported in the literature as the closest compound to the chemical structure of the target compound of the present invention CL04- 0010% or more, wherein the bactericidal activities of the compounds CL04-29-1, CL04-29-2, CL04-35B, CL04-35D, CL04-35A and Gxf01-43A were all above 60%, both higher than the control azoxystrobin And enestrobin esters of more than 10%, wherein the compounds CL04-29-1, CL04-29-2 and CL04-35B have an inhibition rate of more than 75%, and Compounds CL04-29-1 and CL04-29-2 had the highest inhibition rate of 78.57%; the activity against Fusarium graminearum showed that compounds CL04-35E, CL04-29-1, CL04-29-2, Gxf01-45, CL04-30A, CL04-30B, CL04-30C, CL04-30D, CL04-30E, CL04-35B, CL04-35D, CL04-35A, Gxf01-43A, Znl01-19C, Znl01-19A, Znl01-19B, Znl01- The inhibition rates of 19E and Znl01-19D were all above 50%, and the bactericidal activity of the above compounds was higher than that reported in the literature, which is the closest to the chemical structure of the target compound of the present invention, CL04-0010%, and the control drug enestrobin 30. Above %, the inhibition rates of compounds CL04-29-1, CL04-29-2, CL04-30B, CL04-30D, CL04-35B, CL04-35A, Gxf01-43A were all above 80%, both higher than the reference drug More than 10% azoxystrobin, especially compounds CL04-29-1, CL04-30B, CL04-35B and CL04-35 have the highest bactericidal activity, up to 100%; for apple ring rot, compound CL04-35E, CL04- The inhibition rates of 29-1, Gxf01-45, CL04-30C, CL04-30D, CL04-30E, CL04-30F, CL04-35B, CL04-35D, CL04-35A, Znl01-19B and Znl01-19E were all 40%. Above, wherein compound CL04-3 The bactericidal activity of 0C, CL04-35B and CL04-35A was higher than that reported in the literature, which is the closest to the chemical structure of the target compound of the present invention, CL04-0010%, and the compound CL04-35B has the highest inhibition rate of 61.40%, high. For the control drug enestrobin; for the cucumber gray mold, compounds CL04-35E, CL04-29-1, CL04-29-2, CL04-30C, CL04-30D, CL04-30F, CL04-35B, CL04 -35D, CL04-35A, The inhibition rates of Gxf01-43A, Znl01-19E and Znl01-19D were all above 40%, among which compounds CL04-35E, CL04-29-1, CL04-29-2, CL04-30C, CL04-30D, CL04-35B, The bactericidal activities of CL04-35D, CL04-35A, Gxf01-43A and Znl01-19D are higher than those reported in the literature which are closest to the chemical structure of the target compound of the present invention, CL04-0010%, and the compounds CL04-29-1, CL04 The inhibition rates of -29-2, CL04-35B, CL04-35D, CL04-35A and Gxf01-43A were all above 60%, which were higher than the control drug enestrobin by more than 10%. Compounds CL04-29-1, CL04 The inhibition rates of -35B and CL04-35A were all above 80%, especially the compounds CL04-35B and CL04-35A had the highest bactericidal activity, reaching 100%, higher than the control azoxystrobin; for the Sclerotinia sclerotiorum, the compound CL04-35E, CL04-29-1, CL04-29-2, Gxf01-45, CL04-30A, CL04-30B, CL04-30C, CL04-30D, CL04-30E, CL04-30F, CL04-35B, CL04- The bactericidal activities of 35D, CL04-35A, Gxf01-43A, Znl01-19C, Znl01-19A, Znl01-19B, Znl01-19E, Znl01-19D, and Znl01-19F were all above 30%, and the bactericidal activities of the above compounds were higher. Reported in the literature The chemical structure of the target compound is closest to the compound CL04-0010%, among which the compounds CL04-35E, CL04-29-1, CL04-29-2, Gxf01-45, CL04-30B, CL04-30D, CL04-30E, CL04 The bactericidal activities of -30F, CL04-35B, CL04-35D, CL04-35A, Gxf01-43A, and Znl01-19E were all above 60%, both higher than the control drug enestrobin ester by more than 15%, of which compound CL04-29- 1. The inhibition rates of CL04-29-2 and Gxf01-43A were all above 90%, both higher than the control azoxystrobin by more than 10%, and the compounds CL04-29-1 and Gxf01-43A had the highest inhibition rate of 100%. %; for Rhizoctonia cerealis, compounds CL04-35E, CL04-29-1, CL04-29-2, Gxf01-45, CL04-30B, CL04-30C, CL04-30D, CL04-30E, CL04- The bactericidal activities of 30F, CL04-35B, CL04-35D, CL04-35A, Gxf01-43A, Znl01-19E and Znl01-19D are all above 60%. The bactericidal activity of the above compounds is higher than that reported in the literature and the target compound of the present invention. The chemical structure closest to the compound CL04-0040% or more, of which compounds CL04-29-1, CL04-29-2, CL04-30B, CL04-30C, CL04-30E, CL04-35B, CL04-35D, CL04-35A, Gxf01-43A and Znl01-19E The bactericidal activity was above 80%, and the bactericidal activities of the compounds CL04-29-1, CL04-30B, CL04-35B, CL04-35D, CL04-35A, Gxf01-43A and Znl01-19E were higher than the control drug enestrobin More than 10%, especially the compounds CL04-35D, CL04-35A, Gxf01-43A and Znl01-19E have the highest bactericidal activity, up to 100%, higher than the control azoxystrobin by more than 15%; activity against Rhizoctonia solani It is shown that the bactericidal activities of the compounds CL04-35E, CL04-30B, CL04-30C, CL04-30D, CL04-35B, CL04-35D, CL04-35A, Gxf01-43A and Znl01-19E are all above 30%, and the above compounds are The bactericidal activity was higher than that reported in the literature, which is the closest to the chemical structure of the target compound of the present invention, CL04-0010%, and the bactericidal activities of the compounds CL04-30B, CL04-30D, CL04-35A, Gxf01-43A and Znl01-19E. Above 60%, and the bactericidal activities of the compounds CL04-30D, CL04-35A, Gxf01-43A and Znl01-19E were higher than the control drug enestrobin more than 10%, especially the compound CL04-30D had the highest bactericidal activity, reaching 89.19. %, higher than the control drug azoxystrobin; for Phytophthora infestans, compound CL04-35E, CL04-29- 1. CL04-29-2, Gxf01-45, CL04-30B, CL04-30C, CL04-30D, CL04-30E, CL04-30F, CL04-35B, CL04-35D, CL04-35A, Gxf01-43A, Znl01- The bactericidal activity of both 19A and Znl01-19E is above 60%, and the bactericidal activity of the above compounds is higher than that reported in the literature and the target compound of the present invention. The chemical structure closest to the compound CL04-00, enestrobin ester more than 20% and the control drug azoxystrobin more than 10%, of which compounds CL04-35E, CL04-30B, CL04-30C, CL04-30D, CL04-35B, CL04 The bactericidal activity of -35D, CL04-35A, Gxf01-43A, Znl01-19A and Znl01-19E is as high as 100%; in summary, compound CL04-35A has a broad spectrum of bactericidal activity.

实施例6：本发明的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ的抗烟草花叶病毒(TMV)活性：Example 6: Tobacco mosaic virus (TMV) activity of the thiadiazolone methoxy acrylate derivative IV of the present invention:

TMV活性的测定结果见表3，表3表明，本发明的大部分化合物具有较好的抗TMV的活性；在100微克/毫升时，本发明合成的所有化合物均有不同程度的抗TMV活性。在治疗模式下，化合物CL04-30A的治疗活性高出文献报道的与本发明目标化合物化学结构最接近的化合物CL04-00，虽然低于对照药宁南霉素，但是仍然具有较好的治疗效果；在钝化模式下，化合物Gxf01-45、CL04-30C、CL04-30E、CL04-35B、Gxf01-43A、Znl01-19E和Znl01-19F的钝化抑制率在30％以上，上述化合物的钝化活性均高出文献报道的与本发明目标化合物化学结构最接近的化合物CL04-0010％以上，虽然低于对照药病毒唑，但还是表现了较好的钝化活性；在保护模式下，化合物CL04-30A、CL04-30B、CL04-30C、CL04-30D、CL04-35B、CL04-35D、Znl01-19C、Znl01-19A、Znl01-19E和Znl01-19F的保护活性均在40％以上，上述化合物的保护活性均高出文献报道的与本发明目标化合物化学结构最接近的化合物CL04-0010％以上，其中CL04-35B的保护活性与对照药BTH相当；在诱导模式下，化合物CL04-35E、Gxf01-45、CL04-30A、CL04-30B、CL04-30C、CL04-30D、CL04-30F、CL04-35B、CL04-35D、CL04-35A、Znl01-19C、Znl01-19A、Znl01-19E、Znl01-19D、Znl01-19F的诱导活性均在30％以上，上述化合物的诱导活性均高出文献报道的与本发明目标化合物化学结构最接近的化合物CL04-0010％以上，其中化合物CL04-30C、CL04-30D、CL04-35B、CL04-35D、Znl01-19C、Znl01-19A、Znl01-19E的诱导活性在70％以上,尤其是化合物CL04-35D的诱导活性达到了80％，高于对照药TDL、BTH、SZG-7；可见，本发明的大部分化合物具有很好的抗TMV活性。The results of the measurement of TMV activity are shown in Table 3. Table 3 shows that most of the compounds of the present invention have better anti-TMV activity; at 100 μg/ml, all compounds synthesized by the present invention have different degrees of anti-TMV activity. In the therapeutic mode, the therapeutic activity of the compound CL04-30A is higher than that reported in the literature as the closest compound to the target compound of the present invention, CL04-00, although it is lower than the control drug Ningnanmycin, but still has a good therapeutic effect. In passivation mode, the passivation inhibition rates of the compounds Gxf01-45, CL04-30C, CL04-30E, CL04-35B, Gxf01-43A, Znl01-19E and Znl01-19F are above 30%, and the passivation of the above compounds The activity is higher than the reported CL04-0010% of the compound closest to the chemical structure of the target compound of the present invention, although it is lower than the control drug ribavirin, but still exhibits good passivation activity; in the protective mode, the compound CL04 The protective activities of -30A, CL04-30B, CL04-30C, CL04-30D, CL04-35B, CL04-35D, Znl01-19C, Znl01-19A, Znl01-19E and Znl01-19F are all above 40%, and the above compounds are The protective activity was higher than the reported CL04-0010% of the compound closest to the chemical structure of the target compound of the present invention, wherein the protective activity of CL04-35B was comparable to that of the reference drug BTH; in the induction mode, the compounds CL04-35E, Gxf01- 45, CL04-30A Induction activity of CL04-30B, CL04-30C, CL04-30D, CL04-30F, CL04-35B, CL04-35D, CL04-35A, Znl01-19C, Znl01-19A, Znl01-19E, Znl01-19D, Znl01-19F All of them are above 30%, and the inducing activities of the above compounds are higher than those reported in the literature, which are closest to the chemical structure of the target compound of the present invention, CL04-0010%, among which compounds CL04-30C, CL04-30D, CL04-35B, CL04- The induction activities of 35D, Znl01-19C, Znl01-19A and Znl01-19E were above 70%, especially the induction activity of compound CL04-35D reached 80%, which was higher than the control drugs TDL, BTH and SZG-7; Most of the compounds of the invention have excellent anti-TMV activity.

本发明的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ还对水稻矮缩病、黄矮病、条纹叶枯病、番茄蕨叶病毒病、辣椒花叶病毒病、烟草脉坏死病毒病、玉米矮花叶病、花椰菜花叶病毒、柑橘病毒病、建兰花叶病毒病、建兰环斑病毒的农业和林业以及园艺植物病毒病害具有很好的抗病毒活性。The thiadiazolone methoxy acrylate derivative IV of the present invention is also resistant to rice dwarf disease, yellow dwarf disease, stripe leaf blight, tomato fern leaf virus disease, pepper mosaic virus disease, tobacco vein necrosis virus disease, Maize dwarf mosaic disease, cauliflower mosaic virus, citrus virus disease, broccoli virus disease, Jianlan ring spot virus agriculture and forestry, and horticultural plant virus diseases have good antiviral activity.

实施例7：本发明的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ防治黄瓜白粉病的田间试验结果：Example 7: Field test results of the thiadiazolyl ether methoxy acrylate derivative IV of the present invention for controlling cucumber powdery mildew:

本发明对高活性化合物开展了田间药效试验，选择的防治对象名称为：白粉病(Sphaerotheca fuliginea)；选择的试验作物品种为黄瓜“津优40”。施药方法及用水量(升/公顷)：在发病前或者发病初期，采用喷雾法施药。以675L/hm²的药液量对植株均匀喷雾，空白对照喷等量清水。实验结果见表4，表4表明，8.88％CL04-29乳油对黄瓜白粉病的平均防效为76.61；而对照药剂250g/L嘧菌酯SC(英国先正达有限公司生产)的平均防效为70.19％， 50％肟菌酯(FLINT)WG(德国拜耳作物科学公司生产)的平均防效为68.02％。经方差分析和多重比较，8.88％CL04-29乳油37.5克/公顷的防效显著高于两对照药剂250g/L嘧菌酯SC的防效和50％肟菌酯(FLINT)WG的防效。试验期间观察，8.88％CL04-29乳油各处理对黄瓜植株无药害等不良影响。综上所述：8.88％CL04-29乳油对黄瓜白粉病有较好的防效。The invention carries out a field efficacy test on a highly active compound, and the selected control object name is: powdery mildew (Sphaerotheca fuliginea); the selected test crop variety is cucumber "Jinyou 40". Application method and water consumption (liters/ha): Spraying before or after the onset of the disease. The plants were evenly sprayed with a dose of 675 L/hm ² , and the blank control was sprayed with equal amount of water. The experimental results are shown in Table 4. Table 4 shows that the average control effect of 8.88% CL04-29 emulsifiable oil on cucumber powdery mildew is 76.61; and the average control effect of the control agent 250g/L azoxystrobin SC (produced by British Syngenta Co., Ltd.). The average control effect of 70.19%, 50% trifloxystrobin (FLINT) WG (manufactured by Bayer CropScience AG) was 68.02%. After analysis of variance and multiple comparisons, the control effect of 8.88% CL04-29 emulsifiable concentrate 37.5 g/ha was significantly higher than that of the two control agents 250 g/L azoxystrobin SC and the control effect of 50% sputum ester (FLINT) WG. During the experiment, it was observed that 8.88% of CL04-29 emulsifiable concentrate had no adverse effects on cucumber plants. In summary: 8.88% CL04-29 emulsifiable concentrate has good control effect on cucumber powdery mildew.

实施例8：本发明的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ防治黄瓜霜霉病的田间试验结果：Example 8: Field test results of the thiadiazolyl ether methoxy acrylate derivative IV of the present invention for controlling cucumber downy mildew:

本发明对高活性化合物开展了田间药效试验，选择防治对象的名称为：黄瓜霜霉病(Pseudoperponspora cubensis)；选择的试验作物品种为黄瓜“津绿3号”。施药方法及用水量(升/公顷)：在黄瓜霜霉病发病初期，采用喷雾法施药。以675L/hm²的药液量对植株均匀喷雾，空白对照喷等量清水。实验结果见表5，表5表明，8.88％CL04-29乳油对黄瓜霜霉病的平均防效为77.52％；而对照药剂50％肟菌酯(FLINT)WG(德国拜耳作物科学公司生产)的平均防效为72.02％，250g/L吡唑醚菌酯EC(巴斯夫植物保护(江苏)有限公司生产)的平均防效为77.52％。经方差分析和多重比较，8.88％CL04-29乳油75克/公顷的防效与对照药剂250g/L吡唑醚菌酯EC的防效相当，无显著差异；显著高于对照药剂50％肟菌酯WG的平均防效。试验期间观察，8.88％CL04-29乳油对黄瓜植株无药害等不良影响。综合以上试验结果认为：8.88％CL04-29乳油对黄瓜霜霉病有较好的防效。The invention carries out a field efficacy test on a highly active compound, and the name of the selected control object is: cucumber downy mildew (Pseudoperponspora cubensis); the selected test crop variety is cucumber "Jinlu No. 3". Application method and water consumption (liters/ha): In the early stage of cucumber downy mildew, spray application. The plants were evenly sprayed with a dose of 675 L/hm ² , and the blank control was sprayed with equal amount of water. The experimental results are shown in Table 5. Table 5 shows that the average control effect of 8.88% CL04-29 emulsifiable concentrate on cucumber downy mildew is 77.52%; and the control agent 50% sputum ester (FLINT) WG (produced by Bayer CropScience Co., Germany) The average control effect was 72.02%, and the average control effect of 250 g/L pyraclostrobin EC (produced by BASF Plant Protection (Jiangsu) Co., Ltd.) was 77.52%. After analysis of variance and multiple comparisons, the control effect of 8.88% CL04-29 EC 75 g/ha was comparable to that of the control agent 250 g/L pyraclostrobin EC, no significant difference; significantly higher than the control agent 50% The average control effect of the ester WG. During the experiment, 8.88% CL04-29 emulsifiable concentrate had no adverse effects on cucumber plants. Based on the above test results, 8.88% CL04-29 emulsifiable concentrate has good control effect against cucumber downy mildew.

实施例9：本发明的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ与杀虫剂组合在防治农业和林业以及园艺植物虫害中的应用：Example 9: Application of the thiadiazolium ether methoxy acrylate derivative IV of the present invention in combination with an insecticide for controlling agricultural and forestry and horticultural plant pests:

本发明的所有噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ与商品杀虫剂中的任意一种或两种组合形成杀虫组合物用于防治农业和林业以及园艺植物虫害，所述商品杀虫剂选自：毒死蜱、地亚哝、啶虫脒、甲氨基阿维菌素、弥拜菌素、阿维菌素、多杀菌素、氰戊菊酯、高效氰戊菊酯、氯氰菊酯、高效氯氰菊酯、三氟氯氰菊酯、溴氰菊酯、甲氰菊酯、Beta-氟氯氰菊酯、Lambda-三氟氯氰菊酯、二氯苯醚菊酯、苄氯菊酯、丙烯菊酯、联苯菊酯、氯菊酯、醚菊酯、氟氯苯菊酯、氯氟胺氰戊菊酯、吡虫啉、烯啶虫胺、氯噻啉、噻虫啉、噻虫嗪、噻虫胺、呋虫胺、可尼丁、达特南、除虫脲、灭幼脲、伏虫隆、除虫隆、氟铃脲、氟虫脲、啶虫隆、虱螨脲、毒虫脲、氟幼脲、Noviflumuron即多氟脲，其CAS号为121451-02-3、氟螨脲、Novaluron即双苯氟脲、氟啶脲、Bay sir 6874即1-[(3.5-二氯-4)4-硝基苯氧基苯基3-3-(2-氯苯)-脲、Bay SIR-8514即1-(4-三氟甲氧基苯基)-3-(2-氯苯)-脲、嗪虫脲、Bistrifluron即双三氟虫脲、呋喃虫酰肼、虫酰肼、氯虫酰肼、甲氧虫酰肼、环虫酰肼、乐果、氧化乐果、敌敌畏、乙酰甲胺磷、***磷、喹硫磷、哒嗪硫磷、氯唑磷、叶蝉散、西维因、抗蚜威、速灭威、异丙威、杀螟丹、仲丁威、叶飞散、甲萘威、丙硫克百威、丁硫克百威、杀螟丹、溴螨酯、噻螨酮、唑螨酯、哒螨酮、四螨嗪、炔螨特、丁醚脲、吡蚜酮、螺螨酯、螺虫酯、螺虫乙酯、丁烯氟虫腈、***锡、噻嗪酮、灭线磷、氟虫腈、杀虫单、杀虫双、氯虫酰胺、氟虫酰胺、氟氰虫酰胺、氰虫酰胺、唑虫酰胺、溴虫腈、吡嗪酮、乙螨唑、吡螨胺、哒幼酮、吡丙醚、埃玛菌素；本发明的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ在所述杀虫组合物中的质量百分含量是1％-90％，本发明的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ与前述商品杀虫剂的比例为质量百分比1％∶99％到99％∶1％；所述杀虫组合物加工的剂型选自：种子处理乳剂、水乳剂、微乳剂、悬乳剂、胶囊悬浮剂、水溶性粒剂、细粒剂、可溶性浓剂、毒谷、块状毒饵、粒状毒饵、片状毒饵、浓毒饵、缓释块、静电喷雾剂、水包油乳剂、烟雾罐、烟雾烛、烟雾筒、烟雾棒、烟雾片、烟雾丸、发气剂、油膏、热雾剂、冷雾剂、气雾剂、固/液混合装剂、液/液混合装剂、固/固混合装剂、药漆、微粒剂、追踪粉剂、油悬剂、油分散性粉剂、浓胶剂、泼浇剂、种衣剂、涂抹剂、成膜油剂、超低容量液剂、蒸汽释放剂；所述杀虫组合物防治的植物虫害选自：红蜘蛛、东亚飞蝗、云斑车蝗、中华稻蝗、日本黄脊蝗、单刺蝼蛄、东方蝼蛄、稻蓟马、烟蓟马、温室蓟马、稻管蓟马、麦简管蓟马、温室白粉虱、烟粉虱、黑尾叶蝉、大青叶蝉、棉叶蝉、斑衣蜡蝉、褐飞虱、白背飞虱、灰飞虱、甘蔗扁角飞虱、棉蚜、麦二叉蚜、麦长管蚜、桃蚜、高粱蚜、萝卜蚜、吹绵蚧、桑盾蚧、矢尖盾蚧、梨圆蚧、白蜡虫、红蜡蚧、朝鲜球坚蚧、梨网蝽、香蕉网蝽、细角花蝽、微小花蝽、针缘蝽、稻蛛缘蝽、稻褐蝽、稻黑蝽、稻绿蝽、绿盲蝽、苜蓿盲蝽、中黑盲蝽、大草蛉、丽草蛉、中华草蛉、谷蛾、衣蛾、黄刺蛾、褐刺蛾、扁刺蛾、麦蛾、棉红铃虫、甘薯麦蛾、小菜蛾、桃小食心虫、大豆食心虫、桃小食心虫、苹果顶梢卷叶蛾、褐带长卷叶蛾、拟小黄卷叶蛾、二化螟、豆荚螟、玉米螟、三化螟、菜螟、稻纵卷叶螟、条螟、棉卷叶野螟、桃蛀螟、黏虫、斜纹夜蛾、稻螟蛉、棉小造桥虫、甜菜夜蛾、大螟、棉铃虫、鼎点金刚钻、小地老虎、大地老虎、黄地老虎、盗毒蛾、舞毒蛾、甘薯天蛾、豆天蛾、直纹稻弄蝶、隐纹谷弄蝶、柑橘凤蝶、玉带凤蝶、菜粉蝶、苎麻赤蛱蝶、苎麻黄蛱蝶、豆芫菁、金星步甲、皱鞘步甲、麦穗步甲、沟金针虫、细胸金针虫、谷斑皮蠹、黑皮蠹、柑橘小吉丁虫、金缘吉丁虫、黄粉虫、黑粉虫、赤拟谷盗、杂拟谷盗、铜绿异丽金龟、暗黑金龟、华北大黑鳃金龟、桑天牛、星天牛、橘褐天牛、桃红颈天牛、大猿叶虫、小猿叶虫、黄守瓜、黄曲条跳甲、绿豆象、豌豆象、蚕豆象、玉米象、米象、小麦叶蜂、梨实蜂、黄带姬蜂、黏虫白星姬蜂、螟蛉悬茧姬蜂、棉铃虫齿唇姬蜂、螟黑点疣姬蜂、蚊、蝇、虻、麦红吸浆虫、麦黄吸浆虫、稻瘿蚊、柑橘大实蝇、瓜实蝇、麦叶灰潜蝇、美洲斑潜蝇、豆秆黑潜蝇、麦秆蝇、种蝇、葱蝇、萝卜蝇、伞裙追寄蝇、玉米螟厉寄蝇、黏虫；所述杀虫组合物防治的植物选自：稻谷、小麦、大麦、燕麦、玉米、高粱、甘薯、马铃薯、木薯、大豆、荷兰豆、蚕豆、豌豆、绿豆、小豆、棉花、蚕桑、花生、油菜、芝麻、向日葵、甜菜、甘蔗、咖啡、可可、人参、贝母、橡胶、椰子、油棕、剑麻、烟草、番茄、辣椒、萝卜、黄瓜、白菜、芹菜、榨菜、甜菜、油菜、葱、大蒜、西瓜、甜瓜、哈密瓜、木瓜、苹果、柑桔和桃树、茶、山野菜、竹笋、啤酒花、胡椒、香蕉、番木瓜、兰花、盆景。Any of the thiadiazolone methoxy acrylate derivatives IV of the present invention is combined with any one or both of the commercial insecticides to form an insecticidal composition for controlling agricultural and forestry and horticultural plant pests, the commodity The insecticide is selected from the group consisting of: chlorpyrifos, scorpion scorpion, acetamiprid, emamectin, ubiquitin, avermectin, spinosyn, fenvalerate, high-grade fenvalerate, cypermethrin, Beta-cypermethrin, cyhalothrin, deltamethrin, fenpropathrin, Beta-cyfluthrin, Lambda-cyhalothrin, permethrin, permethrin, methrin, bifenthrin, chlorine Pyrethroid, efenthrin, flumethrin, flufenacetate, imidacloprid, nitenpyram, chlorothiazol, thiacloprid, thiamethoxam, clothianidin, dinotefuran, cocoon Ding, Dartnam, diflubenzuron, chlorbenzuron, flubenzuron, chlorfenapyr, hexaflumuron, flubenzuron, acetamiprid, guanidine, chlorfenapyr, fluorolactam, Noviflumuron , its CAS number is 121451-02-3, fluorofurazone, Novaluron, ie, diphenylfluorourea, chlorfluazuron, Bay sir 6874, 1-[(3.5-dichloro- 4) 4-Nitrophenoxyphenyl 3-3-(2-chlorophenyl)-urea, Bay SIR-8514, 1-(4-trifluoromethoxyphenyl)-3-(2-chlorobenzene )-urea, oxazide urea, Bistrifluron, ie, bistriazole, furanyl hydrazide, tebufenozide, chlorfenapyr, methoxyfenozide, chlorfenapyr, dimethoate, omethoate, dichlorvos, Acephate, triazophos, quetiapine, pyridazin, chlorpyrifos, scutellaria, carbaryl, carbaryl, acesulfame, isoprocarb, chlorpyrifos, zhongdingwei, Yefeisan, carbaryl, propyl thiocarbamate, butyl thiocarbamate, chlorpyrifos, bromo oxime ester, thiazolone, oxazolidine, anthrone, tetrazine, alkyne, dibutyl ether urea , pymetrozine, spirodecyl ester, spirotetramat, spirotetramat, butene fipronil, triazole tin, buprofezin, phosphazone, fipronil, insecticidal, insecticidal, chlorantran Amide, flubendiamide, fluocyanamide, cyanamide, oxazolamide, chlorfenapyr, pyrazinone, etoxazole, pyridyl Guanamine, ketone, pyriproxyfen, emamectin; the thiadiazolyl ether methoxy acrylate derivative IV of the present invention has a mass percentage of 1%-90 in the pesticidal composition %, the ratio of the thiadiazolyl ether methoxy acrylate derivative IV of the present invention to the aforementioned commercial insecticide is 1% by mass: 99% to 99%: 1% by mass; the dosage form processed by the insecticidal composition Selected from: seed treatment emulsion, water emulsion, microemulsion, suspoemulsion, capsule suspension, water-soluble granule, fine granule, soluble concentrate, poisonous valley, block bait, granular bait, flake bait, concentrated bait, Sustained release block, electrostatic spray, oil-in-water emulsion, smoke can, smoke candle, smoke tube, smoke stick, smoke sheet, smoke pill, gas generator, ointment, hot spray, cold spray, aerosol, Solid/liquid mixed agent, liquid/liquid mixed agent, solid/solid mixed agent, lacquer, microparticle, trace powder, oil suspension, oil dispersible powder, thickener, pouring agent, seed coating agent , an smear agent, a film forming oil agent, an ultra low volume liquid agent, a steam release agent; a plant worm controlled by the insecticidal composition Damaged from: Star Spider, East Asiatic Flycatcher, Cloud Spot Car, Chinese Rice, Japanese Yellow Ridge, Single Hedgehog, Oriental Dragonfly, Rice Horse, Smoked Horse, Greenhouse Hummer, Rice Pipe Thrips, Wheat蓟管蓟马, greenhouse whitefly, whitefly, black-tailed leafhopper, big green leafhopper, cotton leafhopper, spotted waxhopper, brown planthopper, white-backed planthopper, gray planthopper, sugarcane, flat-horned planthopper, cotton蚜, Mai 蚜蚜, Mai long tube 蚜, peach 蚜, sorghum, radish 吹, 蚧蚧, 桑蚧蚧, 矢蚧蚧, pear round 白, 蜡 wax, red wax 蚧, Korean ball 蚧, Pear nets, banana nets, fine-horned flower buds, tiny flower buds, needle-edge mites, rice spider mites, rice brown mites, rice black mites, rice green mites, green blind mites, ticks, and black scorpions , big grasshopper, licao, Chinese grasshopper, valley moth, clothing moth, yellow moth, brown moth, flat moth, wheat moth, cotton red bollworm, sweet potato moth, diamondback moth, peach small heartworm, soybean Carnivorous worm, Peach worm, Apple leaf roller moth, Brown leaf moth, Pseudosciaena serrata, Chilo suppressalis, Bean scorpion, Corn scorpion, Sanhua scorpion, Vegetable stalk, Rice leaf roller Striped stalks, cotton leaf stalks, peach aphids, armyworms, Spodoptera litura, rice blasts, cotton small bridge worms, beet armyworms, giant salamanders, cotton bollworms, tripod diamonds, small tigers, earth tigers, Yellow tiger, poisonous moth, gypsy moth, sweet potato hawk moth, bean hawk moth, straight grain rice butterfly, cryptic valley butterfly, citrus phoenix butterfly, jade phoenix butterfly, cabbage butterfly, ramie red butterfly, ramie butterfly Bean phthalocyanine, Venus carapace, wrinkle sheath, armor, wheat stalk, sphaerocephala, scutellaria, scutellaria, black scorpion, citrus small gibber, jinji jiding, yellow mealworm , black worm, red worm, pirate, copper green, golden tortoise, dark golden tortoise, turmeric, black mullet, mulberry, stevia, orange, white beetle, pink neck beetle, eucalyptus Insects, small leafhoppers, yellow stalks, yellow stalks, yellow peas, green beans, peas, broad beans, corn, rice, wheat leaf bees, pear bees, yellow belt wasps, worms, white worms, cockroaches The stag beetle, the cotton bollworm, the larvae, the cockroach, the cockroach, the cockroach, the cockroach, the cockroach, the larvae, the larvae, the rice blast, Bactrocera dorsalis, melon flies, larvae, larvae, larvae, stalks, stalks, stalks, stalks, stalks, stalks, stalks, stalks , the armyworm; the plant controlled by the insecticidal composition is selected from the group consisting of: rice, wheat, barley, oats, corn, sorghum, sweet potato, potato, cassava, soybean, pea, broad bean, pea, mung bean, adzuki bean, cotton, sericulture, Peanut, canola, sesame, sunflower, beet, sugar cane, coffee, cocoa, ginseng, fritillary, rubber, coconut, oil palm, sisal, tobacco, tomato, pepper, radish, cucumber, cabbage, celery, mustard, beet, rape Onions, garlic, watermelon, melon, cantaloupe, papaya, apple, citrus and peach, tea, wild vegetables, bamboo shoots, hops, pepper, banana, papaya, orchid, bonsai.

实施例10：本发明的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ与杀菌剂组合在防治农业和林业以及园艺植物病害中的应用：Example 10: The thiadiazolyl ether methoxy acrylate derivative IV of the present invention is combined with a bactericide in the control of agriculture and forestry And applications in horticultural plant diseases:

本发明的所有噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ与商品杀菌剂中的任意一种或两种组合形成杀菌组合物用于防治农业和林业以及园艺植物病害，所述商品杀菌剂选自：苯并噻二唑、噻酰菌胺，简写为TDL、噻酰胺、甲噻诱胺、4-甲基-1,2,3-噻二唑-5-甲酸、4-甲基-1,2,3-噻二唑-5-甲酸钠、4-甲基-1,2,3-噻二唑-5-甲酸乙酯、DL-β-氨基丁酸、异噻菌胺，其英文通用名为：isotianil、3,4-二氯异噻唑-5-甲酸、3,4-二氯异噻唑-5-甲酸钠、3,4-二氯异噻唑-5-甲酸乙酯、病毒唑、安托芬、宁南霉素或水杨酸、霜脲氰、福美双、福美锌、代森锰锌、乙磷铝、甲基硫菌灵、百菌清、敌可松、腐霉利、苯锈啶、甲基托布津、托布津、精甲霜灵、氟吗啉、烯酰吗啉、高效甲霜灵、高效苯霜灵、双氯氰菌胺、磺菌胺、甲磺菌胺、噻氟菌胺、氟酰胺、叶枯酞、环丙酰菌胺、环氟菌胺、环酰菌胺、氰菌胺、硅噻菌胺、呋吡菌胺、吡噻菌胺、双炔酰菌胺、苯酰菌胺、甲呋酰胺、萎锈灵、乙菌利、异菌脲、嘧菌酯、醚菌胺、氟嘧菌酯、醚菌酯、苯氧菌胺、肟醚菌胺、啶氧菌酯、唑菌胺酯、肟菌酯、烯肟菌酯、烯肟菌胺、氧环唑、糠菌唑、环丙唑醇、苯醚甲环唑、烯唑醇、高效烯唑醇、氟环唑、腈苯唑、氟喹唑、氟硅唑、粉唑醇、己唑醇、亚胺唑、种菌唑、叶菌唑、腈菌唑、戊菌唑、丙环唑、丙硫菌唑、硅氟唑、戊唑醇、四氟醚唑、***醇、灭菌唑、联苯***醇、噻菌灵、麦穗宁、抑霉唑、高效抑霉唑、咪鲜胺、氟菌唑、氰霜唑、咪唑菌酮、噁咪唑、稻瘟酯、噁唑菌酮、啶菌噁唑、噁霉灵、噁霜灵、噻唑菌胺、土菌灵、辛噻酮、苯噻硫氰、十二环吗啉、丁苯吗啉、十三吗啉、拌种咯、咯菌腈、氟啶胺、啶斑肟、环啶菌胺、啶酰菌胺、氟啶酰菌胺、啶菌胺、嘧菌环胺、氟嘧菌胺、嘧菌腙、嘧菌胺、嘧霉胺、氯苯嘧啶醇、氟苯嘧啶醇、灭螨猛、二氰蒽醌、乙氧喹啉、羟基喹啉、丙氧喹啉、苯氧喹啉、乙霉威、异丙菌胺、苯噻菌胺、霜霉威、磺菌威、敌瘟磷、异稻瘟净、吡菌磷、甲基立枯磷、灭瘟素、春雷霉素、多抗霉素、多氧霉素、有效霉素、井冈霉素、链霉素、甲霜灵、呋霜灵、苯霜灵、呋酰胺、灭锈胺、多菌灵、苯菌灵、甲基硫菌灵、***酮、乙嘧酚磺酸酯、二甲嘧酚、乙嘧酚、敌菌丹、克菌丹、灭菌丹、乙烯菌核利、氟氯菌核利、菌核净、百菌清、稻瘟灵、稻瘟净、叶枯唑、五氯硝基苯、丙森锌、三乙膦酸铝、硫磺、波尔多液、硫酸铜、氧氯化铜、氧化亚铜、氢氧化铜、苯菌酮、戊菌隆、哒菌酮、四氯苯酞、咯喹酮、螺环菌胺、三环唑、嗪胺灵、多果啶、双胍辛盐、双胍辛胺、氯硝胺、苯磺菌胺、甲苯磺菌胺、吲哚酯、敌磺钠、喹菌酮、烯丙苯噻唑、溴硝醇、碘甲烷、威百亩、敌线酯、棉隆、二氯异丙醚、噻唑磷、硫线磷、丰索磷、虫线磷、苯线磷、灭线磷、除线磷、氯唑磷、丁硫环磷、杀线威、涕灭威、克百威、硫酰氟、二氯丙烯、二氯异烟酸、烯丙异噻唑；本发明的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ在所述杀菌组合物中的总的质量百分含量是1％-90％，本发明的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ与前述商品杀菌剂的比例为质量百分比1％∶99％到99％∶1％；所述杀菌组合物加工的剂型选自：种子处理乳剂、水乳剂、微乳剂、悬乳剂、胶囊悬浮剂、水溶性粒剂、细粒剂、可溶性浓剂、毒谷、块状毒饵、粒状毒饵、片状毒饵、浓毒饵、缓释块、静电喷雾剂、水包油乳剂、烟雾罐、烟雾烛、烟雾筒、烟雾棒、烟雾片、烟雾丸、发气剂、油膏、热雾剂、冷雾剂、气雾剂、固/液混合装剂、液/液混合装剂、固/固混合装剂、药漆、微粒剂、追踪粉剂、油悬剂、油分散性粉剂、浓胶剂、泼浇剂、种衣剂、涂抹剂、成膜油剂、超低容量液剂、蒸汽释放剂；所述杀菌组合物防治的植物病害选自：稻苗绵腐病、番茄根腐病、马铃薯晚疫病、烟草黑胫病、谷子白粉病、葡萄霜霉病、莴苣霜霉病、黄瓜霜霉病、黄瓜炭疽病；所述杀菌组合物适用的植物选自：稻谷、小麦、大麦、燕麦、玉米、高粱、甘薯、马铃薯、木薯、大豆、荷兰豆、蚕豆、豌豆、绿豆、小豆、棉花、蚕桑、花生、油菜、芝麻、向日葵、甜菜、甘蔗、咖啡、可可、人参、贝母、橡胶、椰子、油棕、剑麻、烟草、番茄、辣椒、萝卜、黄瓜、白菜、芹菜、榨菜、甜菜、油菜、葱、大蒜、西瓜、甜瓜、哈密瓜、木瓜、苹果、柑桔和桃树、茶、山野菜、竹笋、啤酒花、胡椒、香蕉、番木瓜、兰花、盆景。Any of the thiadiazolone methoxy acrylate derivatives IV of the present invention and any one or both of the commercial bactericides are combined to form a bactericidal composition for controlling agricultural and forestry and horticultural plant diseases, the commercial bactericide Selected from: benzothiadiazole, thiazide, abbreviated as TDL, thiazamide, methyl thiazide, 4-methyl-1,2,3-thiadiazole-5-carboxylic acid, 4-methyl- 1,2,3-thiadiazol-5-formate, 4-methyl-1,2,3-thiadiazole-5-carboxylic acid ethyl ester, DL-β-aminobutyric acid, isothiazide, English Common names: isotianil, 3,4-dichloroisothiazol-5-carboxylic acid, 3,4-dichloroisothiazol-5-formate, 3,4-dichloroisothiazol-5-carboxylic acid ethyl ester, ribavirin, Antofin, ningnanmycin or salicylic acid, cymoxanil, thiram, thiram, mancozeb, ethylphosphonium, thiophanate, chlorothalonil, diclofenac, procymidone, Benzene pyridine, methyl thiophanate, thiophanate, refined metalaxyl, flumorph, enoylmorpholine, high-performance metalaxyl, high-efficiency benzoxanthin, chloramphenicol, sulfamethoxazole, mesamide , thifluzamide, fluoroamide, leaf sputum, cyclopropionamide, cycloflufenamide, cyclyl Amine, cyanamide, thiastrobin, flufenamide, penthiopyram, dipropionamide, fenhexamide, mefenamide, rust, acetophene, iprodiurea, azoxystrobin Ester, leptin, fluoxastrobin, ether oxystrobin, phenoxystrobin, anthracycline, picoxystrobin, pyraclostrobin, trifloxystrobin, enestrobin, enestrobin, oxygen Cyclosazole, carbendazole, cyproconazole, difenoconazole, diniconazole, high-efficiency diniconazole, epoxiconazole, nitrile azole, fluoroquinazole, flusilazole, fluconazole, hexaconazole , imidazole, inocastazole, cytosine, myclobutanil, penconazole, propiconazole, prothioconazole, flufenazole, tebuconazole, tetrafluoroetherazole, triazole alcohol, azole , biphenyl triazole alcohol, thiabendazole, wheat spike, imazalil, high-efficiency imazalil, prochloraz, fluconazole, cyanoxazole, imidacloprid, meemazole, rice sterol, oxazolid Ketone, pyridine oxazole, carbendazim, oxacillin, ethaboxam, carbendazim, thiazepine, thiothiazide, dodecaline morpholine, butyl morpholine, thirteen morpholine, seed dressing Ol, fluronitrile, fluazinam, aglycone, Cyclohexamide, boscalid, fluridine Amidine, acridine, cyprodinil, fluzalazine, azoxystrobin, azoxystrobin, pyrimethanil, chlorpyrimidine, fluoropyrimidinol, chlorpyrifos, dicyandiamide, ethoxy Quinoline, hydroxyquinoline, propoxyquinoline, phenoxyquinoline, carbendazim, isopropylidene, phenothimethoxazole, propamocarb, sulfavir, enemies, diarrhea, pyridoxine Phosphorus, methyl chlorpyrifos, quercetin, chunleimycin, polymycin, polyoxomycin, tyrosin, jinggangmycin, streptomycin, metalaxyl, furosemide, benzoxanthin, Furfuramide, rust-killing amine, carbendazim, benomyl, thiophanate-methyl, triadimefon, acetazol sulfonate, dipyridamole, ethylpyrrolidone, captan, captan, and extinction Bacterium, vinyl nucleus, chlorofluorobacteria, sclerotium, chlorothalonil, indigo, rice blast, leaf azole, pentachloronitrobenzene, zinc propyl, aluminum triethylphosphinate, Sulfur, Bordeaux mixture, copper sulfate, copper oxychloride, cuprous oxide, copper hydroxide, benomyl, pentosan, chlorfenapyr, tetrachlorophenyl hydrazine, praziquantel, spiroxanthin, tricyclazole , pyrazinamide, polyglycoside, biguanide salt, bis-octylamine, Chloramine, benzepamide, toluidine, oxime ester, sodium sulfonate, quetiace, allyl benzothiazole, bronopol, methyl iodide, Weibaimu, enemy ester, cotton, two Chloroisopropyl ether, thiazolyl, thiophosphorus, folsop, phosphorus, benzene, phosphorus, phosphide, phosphatidylcholine, butyl thiophosphorus, chlorpyrifos, aldicarb, gram Budson, sulfuryl fluoride, dichloropropene, dichloroisonicotinic acid, allylisothiazole; the total mass of the thiadiazolyl ether methoxy acrylate derivative IV of the present invention in the germicidal composition The content is 1% to 90%, and the ratio of the thiadiazolyl ether methoxy acrylate derivative IV of the present invention to the commercial bactericide is 1% by mass: 99% to 99%: 1% by mass; The dosage form processed by the composition is selected from the group consisting of: seed treatment emulsion, water emulsion, microemulsion Agent, suspoemulsion, capsule suspension, water-soluble granule, fine granule, soluble concentrate, poisonous valley, block bait, granular bait, flake bait, concentrated bait, slow release block, electrostatic spray, oil-in-water Emulsions, smoke cans, smoke candles, smoke tubes, smoke sticks, smoke sheets, smoke pills, gas generators, ointments, hot sprays, cold sprays, aerosols, solid/liquid mixtures, liquid/liquid mixtures Charge, solid/solid mixed agent, lacquer, granule, trace powder, oil suspension, oil dispersible powder, thick glue, pouring agent, seed coating agent, smear agent, film forming oil agent, ultra low a volume liquid agent, a steam release agent; the plant disease controlled by the bactericidal composition is selected from the group consisting of: rice seedling cotton rot, tomato root rot, potato late blight, tobacco black shank, millet powdery mildew, grape downy mildew, lettuce Downy mildew, cucumber downy mildew, cucumber anthracnose; the bactericidal composition is suitable for plants selected from the group consisting of: rice, wheat, barley, oats, corn, sorghum, sweet potato, potato, cassava, soybean, pea, broad bean, pea, Mung beans, adzuki beans, cotton, sericulture, peanuts, rape Sesame, sunflower, beet, sugar cane, coffee, cocoa, ginseng, fritillary, rubber, coconut, oil palm, sisal, tobacco, tomato, pepper, radish, cucumber, cabbage, celery, mustard, beet, rape, onion, garlic , watermelon, melon, cantaloupe, papaya, apple, citrus and peach, tea, wild vegetables, bamboo shoots, hops, pepper, banana, papaya, orchid, bonsai.

实施例11：本发明的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ与抗植物病毒剂组合在防治农业和林业以及园艺植物病毒病害中的应用：Example 11: Application of the thiadiazolyl ether methoxy acrylate derivative IV of the present invention in combination with an anti-plant virus agent for controlling agricultural and forestry and horticultural plant virus diseases:

本发明的所有噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ与商品抗病毒药剂中的任意一种或两种组合形成抗病毒组合物用于防治农业和林业以及园艺植物病毒病害，所述商品抗病毒药剂选自：苯并噻二唑、噻酰菌胺，简写为TDL、异噻菌胺，其英文通用名为：isotianil、4-甲基-1,2,3-噻二唑-5-甲酸、4-甲基-1,2,3-噻二唑-5-甲酸钠、4-甲基-1,2,3-噻二唑-5-甲酸乙酯、3,4-二氯异噻唑-5-甲酸、3,4-二氯异噻唑-5-甲酸钠、3,4-二氯异噻唑-5-甲酸乙酯、DL-β-氨基丁酸、病毒唑、安托芬、宁南霉素、噻酰胺、甲噻诱胺或水杨酸、嘧肽霉素、二氯异烟酸、烯丙异噻唑、井冈羟胺、井冈霉素；本发明的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ在所述抗病毒组合物中的总的质量百分含量是1％-90％，本发明的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ与前述商品抗植物病毒剂的比例为质量百分比1％∶99％到99％∶1％；所述抗病毒组合物加工的剂型选自：种子处理乳剂、水乳剂、微乳剂、悬乳剂、胶囊悬浮剂、水溶性粒剂、细粒剂、可溶性浓剂、毒谷、块状毒饵、粒状毒饵、片状毒饵、浓毒饵、缓释块、静电喷雾剂、水包油乳剂、烟雾罐、烟雾烛、烟雾筒、烟雾棒、烟雾片、烟雾丸、发气剂、油膏、热雾剂、冷雾剂、气雾剂、固/液混合装剂、液/液混合装剂、固/固混合装剂、药漆、微粒剂、追踪粉剂、油悬剂、油分散性粉剂、浓胶剂、泼浇剂、种衣剂、涂抹剂、成膜油剂、超低容量液剂、蒸汽释放剂；所述抗病毒组合物防治的病毒病害选自：水稻矮缩病、黄矮病、条纹叶枯病、番茄蕨叶病毒病、辣椒花叶病毒病、烟草脉坏死病毒病、玉米矮花叶病、花椰菜花叶病毒、柑橘病毒病、建兰花叶病毒、建兰环斑病毒；所述抗病毒组合物用于防治的植物选自：稻谷、小麦、大麦、燕麦、玉米、高粱、甘薯、马铃薯、木薯、大豆、荷兰豆、蚕豆、豌豆、绿豆、小豆、棉花、蚕桑、花生、油菜、芝麻、向日葵、甜菜、甘蔗、咖啡、可可、人参、贝母、橡胶、椰子、油棕、剑麻、烟草、番茄、辣椒、萝卜、黄瓜、白菜、芹菜、榨菜、甜菜、油菜、葱、大蒜、西瓜、甜瓜、哈密瓜、木瓜、苹果、柑桔和桃树、茶、山野菜、竹笋、啤酒花、胡椒、香蕉、番木瓜、兰花、盆景。All of the thiadiazolidine methoxy acrylate derivatives IV of the present invention are combined with any one or both of the commercial antiviral agents to form an antiviral composition for controlling agricultural and forestry and horticultural plant virus diseases, The commercial antiviral agent is selected from the group consisting of: benzothiadiazole, thiazide, abbreviated as TDL, isothiazide, and its common name in English is: isotianil, 4-methyl-1,2,3-thiadiazole- 5-carboxylic acid, 4-methyl-1,2,3-thiadiazol-5-formate, 4-methyl-1,2,3-thiadiazole-5-carboxylic acid ethyl ester, 3,4-dichloro Isothiazol-5-carboxylic acid, 3,4-dichloroisothiazol-5-formate, 3,4-dichloroisothiazol-5-carboxylic acid ethyl ester, DL-β-aminobutyric acid, ribavirin, antofin, Ningnanmycin, thiamamide, methotrexate or salicylic acid, glutathione, dichloroisonicotinic acid, allylisothiazole, Jinggang hydroxylamine, Jinggangmycin; thiadiazole ether methoxylate of the present invention The total mass percentage of the acrylate derivative IV in the antiviral composition is from 1% to 90%, the thiadiazolyl ether methoxy acrylate derivative IV of the present invention and the aforementioned commercial anti-plant virus The proportion of the agent is 1% by mass 99% to 99%: 1%; the antiviral composition processed dosage form is selected from the group consisting of: seed treatment emulsion, water emulsion, microemulsion, suspoemulsion, capsule suspension, water-soluble granule, fine granule, soluble thickener , poisonous valley, block bait, granular bait, flake bait, concentrated bait, slow release block, electrostatic spray, oil-in-water emulsion, smoke can, smoke candle, smoke tube, smoke stick, smoke sheet, smoke pill, hair Air agent, ointment, hot mist, cold spray, aerosol, solid/liquid mixed charge, liquid/liquid mixed charge, solid/solid mixed charge, lacquer, microparticle, tracking powder, oil suspension Agent, oil dispersible powder, thickener, splashing agent, seed coating agent, smear agent, film forming oil agent, ultra low volume liquid agent, steam release agent; the virus disease controlled by the antiviral composition is selected from the group consisting of: Rice dwarf disease, yellow dwarf disease, stripe leaf blight, tomato fern leaf virus disease, pepper mosaic virus disease, tobacco vein necrosis virus disease, corn dwarf mosaic disease, cauliflower mosaic virus, citrus virus disease, orchid leaf Virus, Jianlan ring spot virus; the antiviral composition is used for prevention and treatment Is selected from: rice, wheat, barley, oats, corn, sorghum, sweet potato, potato, tapioca, soybean, peas, beans, peas, green beans, red beans, cotton, mulberry, peanut, rapeseed, sesame, sunflower, sugar beet, Sugar cane, coffee, cocoa, ginseng, fritillary, rubber, coconut, oil palm, sisal, tobacco, tomato, pepper, radish, cucumber, cabbage, celery, mustard, beet, canola, onion, garlic, watermelon, melon, cantaloupe , papaya, apple, citrus and peach trees, tea, wild vegetables, bamboo shoots, hops, pepper, banana, papaya, orchid, bonsai.

实施例12：本发明的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ与杀螨剂组合在防治农业和林业以及园艺植物螨害中的应用：Example 12: Application of the thiadiazolyl ether methoxy acrylate derivative IV of the present invention in combination with an acaricide in controlling agricultural and forestry and horticultural plant damage:

本发明的所有噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ与商品杀螨剂中的任意一种或两种组合形成杀螨组合物用于防治农业和林业以及园艺植物螨害，所述商品杀螨剂选自：***锡、三环锡、苯丁锡、三磷锡、毒虫畏、甲基毒虫畏、巴毒磷、敌敌畏、庚烯磷、速灭磷、久效磷、二溴磷、毒死蜱、嘧啶磷、氯甲亚胺硫磷、氧乐果、敌杀磷、乙硫磷、马拉硫磷、虫螨畏、伏杀硫磷、辛硫磷、甲基嘧啶硫磷、喹硫磷、治螟磷、***磷、蚜灭多、水胺硫磷、甲胺磷、胺丙畏、氯亚胺硫磷、亚胺硫磷、氟丙菊酯、联苯菊酯、氯氟氰菊酯、精高效氯氟氰菊酯、甲氰菊酯、氟氰戊菊酯、氟氯苯菊酯、氟胺氰菊酯、溴氟菊酯、联苯肼酯、苯硫威、涕灭威、丁酮威、杀线威、抗虫威、久效威、苯菌灵、氯灭杀威、克百威、丁硫克百威、速灭威、蜱虱威、伐虫脒、单甲脒、杀螨脒、双甲脒、杀虫脒、苯甲酸苄酯、溴螨酯、丁氟螨酯、灭螨醌、氟蚜螨、氟虫脲、浏阳霉素、虫螨霉素、苏云金素、杀螨素、浏阳霉素、阿维菌素、多拉菌素、埃普利诺菌素、伊维菌素、赛拉菌素、莫西菌素、除虫菊素、烟碱、苦参碱、印楝素、鱼藤酮、吡螨胺、哒螨酮、唑螨酯、四螨嗪、炔螨特、噻螨酮、螺螨酯、嘧螨酯、杀螨酯、克螨特、哒螨灵；本发明的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ在所述杀螨组合物中的总的质量百分含量是1％-90％，本发明的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ与所述商品杀螨剂的比例为质量百分比1％∶99％到99％∶1％；所述杀螨组合物加工的剂型选自：种子处理乳剂、水乳剂、微乳剂、悬乳剂、胶囊悬浮剂、水溶性粒剂、细粒剂、可溶性浓剂、毒谷、块状毒饵、粒状毒饵、片状毒饵、浓毒饵、缓释块、静电喷雾剂、水包油乳剂、烟雾罐、烟雾烛、烟雾筒、烟雾棒、烟雾片、烟雾丸、发气剂、油膏、热雾剂、冷雾剂、气雾剂、固/液混合装剂、液/液混合装剂、固/固混合装剂、药漆、微粒剂、追踪粉剂、油悬剂、油分散性粉剂、浓胶剂、泼浇剂、种衣剂、涂抹剂、成膜油剂、超低容量液剂、蒸汽释放剂；所述杀螨组合物防治的螨害选自：螨害选自叶螨科、细须螨科、呋线螨、瘿螨科、红叶螨属、瘿螨科的害螨，这些害螨是世界性农业害螨、林业害螨、园艺害螨和卫生害螨；所述杀螨组合物用于防治的植物选自：稻谷、小麦、大麦、燕麦、玉米、高粱、甘薯、马铃薯、木薯、大豆、荷兰豆、蚕豆、豌豆、绿豆、小豆、棉花、蚕桑、花生、油菜、芝麻、向日葵、甜菜、甘蔗、咖啡、可可、人参、贝母、橡胶、椰子、油棕、剑麻、烟草、番茄、辣椒、萝卜、黄瓜、白菜、芹菜、榨菜、甜菜、油菜、葱、大蒜、西瓜、甜瓜、哈密瓜、木瓜、苹果、柑桔和桃树、茶、山野菜、竹笋、啤酒花、胡椒、香蕉、番木瓜、兰花、盆景。 All of the thiadiazolidine methoxy acrylate derivatives IV of the present invention are combined with any one or both of the commercial acaricides to form acaricidal compositions for controlling agricultural and forestry and horticultural plant damage. Commercial acaricides are selected from the group consisting of triazolium tin, tricyclotin, phenbutyltin, triphosphorus, chlorpyrifos, methyl chlorpyrifos, phytophos, dichlorvos, heptene phosphorus, quick-kill phosphorus, monocrotophos, and Bromphophos, chlorpyrifos, pyrimidine phosphorus, chloromethionine, omethoate, chlorpyrifos, ethion, malathion, chlorpyrifos, sulforaphane, phoxim, methyl pyrithione , quetiapine, strontium phosphate, triazophos, quenching, acesulfame, methamidophos, acesulfame, chloroimidate, imipenem, flumethrin, bifenthrin , cyhalothrin, cyhalothrin, fenpropathrin, fluvalerate, flumethrin, fluvalinate, bifenthrin, bifenyl ester, phenyl sulphur Wei, aldicarb, butanone, chlorpyrifos, insecticide, Jiuweiwei, benomyl, chlorhexidine, carbofuran, butyl thiocarb, chlorpyrifos, suiwei, slash Insects, monothyroid,螨脒, amitraz, chlorpyrifos, benzyl benzoate, bromo oxime ester, butyl fluoro ester, guanidine, fluoroquinone, flufenacetil, liuyangmycin, echinomycin, sulphate, kill Alizarin, liuyangmycin, avermectin, doramectin, eplenomycin, ivermectin, serramycin, moxidectin, pyrethrin, nicotine, matrine, imprint Alizarin, rotenone, pyridoxamine, anthrone, oxazolidine, tetrazine, alkyne , thiazolone, spirodecyl ester, pyridoxine, acaricidal ester, ketone, hydrazine; The total mass percentage of the inventive thiadiazolyl ether methoxy acrylate derivative IV in the acaricidal composition is from 1% to 90%, the thiadiazolyl ether methoxy acrylate of the invention The ratio of the derivative IV to the commercial acaricide is 1% by mass: 99% to 99%: 1% by mass; the dosage form processed by the acaricidal composition is selected from the group consisting of: a seed treatment emulsion, an aqueous emulsion, a microemulsion, and a suspension Emulsion, capsule suspension, water-soluble granules, fine granules, soluble concentrate, poisonous valley, block bait, granular bait, flake bait, concentrated bait, slow release block, static electricity Aerosol, oil-in-water emulsion, smoke can, smoke candle, smoke tube, smoke stick, smoke sheet, smoke pill, gas generator, ointment, hot spray, cold spray, aerosol, solid/liquid mixture Agent, liquid/liquid mixed agent, solid/solid mixed agent, lacquer, granule, trace powder, oil suspension, oil dispersible powder, thickener, pouring agent, seed coating agent, smear agent, Membrane oil agent, ultra low volume liquid agent, steam release agent; the cockroach damage controlled by the acaricidal composition is selected from the group consisting of: the cockroach damage is selected from the group consisting of the genus Aphididae, the genus Euphorbiaceae, the eucalyptus, the genus Amaranthus, the genus Amaranthus, The pests of the family are the world's agricultural pests, forest pests, horticultural pests and health hazards; the plants used for the control of the acaricidal composition are selected from the group consisting of: rice, wheat, barley, oats , corn, sorghum, sweet potato, potato, cassava, soybean, pea, broad bean, pea, mung bean, adzuki bean, cotton, sericulture, peanut, rape, sesame, sunflower, sugar beet, sugar cane, coffee, cocoa, ginseng, fritillaria, rubber, Coconut, oil palm, sisal, tobacco, tomato, pepper, radish, Melon, cabbage, celery, mustard, beet, rape, onion, garlic, watermelon, melon, cantaloupe, papaya, apple, citrus and peach, tea, wild vegetables, bamboo shoots, hops, pepper, banana, papaya, orchid, Bonsai.

表1 本发明的噻二唑肟醚甲氧基丙烯酸酯衍生物的化学结构和理化参数Table 1 Chemical structure and physical and chemical parameters of the thiadiazolyl ether methoxy acrylate derivative of the present invention

表2 本发明的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ的抑菌活性(50微克/毫升的抑制率/％)Table 2 Antibacterial activity of the thiadiazolyl ether methoxy acrylate derivative IV of the present invention (inhibition rate/% of 50 μg/ml)

序号Serial number	化合物Compound	ASAS	CACA	GZGZ	PPPP	BCBC	SSSS	RCRC	PSPS	PIPI
11	CL04-35ECL04-35E	34.4334.43	44.0044.00	54.5554.55	40.3540.35	47.3747.37	60.0060.00	75.6175.61	35.1435.14	100100
22	CL04-29-1CL04-29-1	48.5748.57	78.5778.57	100100	47.3747.37	88.4688.46	100100	92.6292.62	6.676.67	80.0080.00
33	CL04-29-2CL04-29-2	37.1437.14	78.5778.57	94.7494.74	33.3333.33	69.2369.23	96.0096.00	83.6183.61	6.676.67	80.0080.00
44	Gxf01-45Gxf01-45	27.8727.87	36.0036.00	54.5554.55	40.3540.35	31.5831.58	80.0080.00	65.8565.85	13.5113.51	71.4371.43
55	CL04-30ACL04-30A	8.208.20	12.0012.00	54.5554.55	33.3333.33	31.5831.58	40.0040.00	21.9521.95	2.702.70	42.8642.86
66	CL04-30BCL04-30B	8.208.20	12.0012.00	100100	29.8229.82	36.8436.84	60.0060.00	85.3785.37	62.1662.16	100100
77	CL04-30CCL04-30C	27.8727.87	44.0044.00	63.6463.64	50.8850.88	52.6352.63	46.6746.67	80.4980.49	40.5440.54	100100
88	CL04-30DCL04-30D	34.4334.43	44.0044.00	100100	43.8643.86	57.8957.89	73.3373.33	75.6175.61	89.1989.19	100100
99	CL04-30ECL04-30E	14.7514.75	20.0020.00	45.4545.45	47.3747.37	31.5831.58	66.6766.67	80.4980.49	8.118.11	80.9580.95
1010	CL04-30FCL04-30F	4.704.70	20.0020.00	35.4235.42	43.3543.35	41.5341.53	61.6061.60	78.4478.44	13.1113.11	60.9560.95
1111	CL04-35BCL04-35B	60.6660.66	76.0076.00	100100	61.4061.40	100100	80.0080.00	85.3785.37	35.1435.14	100100
1212	CL04-35DCL04-35D	40.9840.98	68.0068.00	54.5554.55	43.8643.86	78.9578.95	66.6766.67	100100	40.5440.54	100100
1313	CL04-35ACL04-35A	47.5447.54	68.0068.00	100100	57.8957.89	100100	73.3373.33	100100	78.3878.38	100100
1414	Gxf01-43AGxf01-43A	34.4334.43	60.0060.00	81.8281.82	33.3333.33	73.6873.68	100100	100100	67.5767.57	100100
1515	Znl01-19CZnl01-19C	8.208.20	12.0012.00	45.4545.45	8.778.77	31.5831.58	33.3333.33	21.9521.95	8.118.11	33.3333.33
1616	Znl01-19AZnl01-19A	8.208.20	20.0020.00	54.5554.55	33.3333.33	31.5831.58	40.0040.00	56.1056.10	24.3224.32	100100
1717	Znl01-19BZnl01-19B	8.208.20	20.0020.00	45.4545.45	47.3747.37	31.5831.58	33.3333.33	51.2251.22	8.118.11	23.8123.81
1818	Znl01-19EZnl01-19E	34.4334.43	44.0044.00	100100	47.3747.37	42.1142.11	60.0060.00	100100	78.3878.38	100100
1919	Znl01-19DZnl01-19D	14.7514.75	20.0020.00	45.4545.45	1.751.75	47.3747.37	46.6746.67	60.9860.98	13.5113.51	33.3333.33
2020	Znl01-19FZnl01-19F	12.7012.70	20.0020.00	35.4535.45	2.752.75	37.3037.30	36.6736.67	40.9040.90	23.5223.52	23.3323.33
21twenty one	CL04-00CL04-00	21.5421.54	22.6022.60	29.6329.63	36.9736.97	32.4432.44	22.6422.64	12.0312.03	21.2821.28	32.0232.02
22twenty two	嘧菌酯Azoxystrobin	75.0075.00	55.5655.56	71.4371.43	100100	91.1891.18	88.1088.10	84.0684.06	80.7780.77	46.8846.88
23twenty three	烯肟菌酯Enoxacin	50.0050.00	55.2255.22	21.5421.54	59.0959.09	48.5748.57	44.0044.00	73.9773.97	57.5057.50	32.9732.97

表3 本发明的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ的抗烟草花叶病毒活性(100微克/毫升的抑制率/％)Table 3 Anti-tobacco mosaic virus activity of the thiadiazolone methoxy acrylate derivative IV of the present invention (100 μg/ml inhibition rate/%)

序号Serial number	化合物Compound	治疗模式Treatment mode	钝化模式Passivation mode	保护模式Protection mode	诱导模式Induction mode
11	CL04-35ECL04-35E	1.52±0.621.52±0.62	24.76±0.6724.76±0.67	38.91±3.7738.91±3.77	39.91±3.7939.91±3.79
22	CL04-29-1CL04-29-1	13.71±0.9113.71±0.91	18.10±3.3018.10±3.30	18.86±0.8518.86±0.85	28.86±0.8328.86±0.83
33	CL04-29-2CL04-29-2	23.59±0.4923.59±0.49	20.48±0.8220.48±0.82	29.03±2.5029.03±2.50	19.03±5.5019.03±5.50
44	Gxf01-45Gxf01-45	4.62±0.554.62±0.55	31.75±2.7531.75±2.75	32.82±0.1432.82±0.14	33.82±0.1933.82±0.19
55	CL04-30ACL04-30A	32.67±0.5132.67±0.51	00	40.67±2.8340.67±2.83	50.67±4.8350.67±4.83
66	CL04-30BCL04-30B	27.80±0.6427.80±0.64	10.73±0.95210.73±0.952	42.14±1.6442.14±1.64	52.14±0.6452.14±0.64
77	CL04-30CCL04-30C	15.49±3.4515.49±3.45	31.14±2.5731.14±2.57	53.64±0.7653.64±0.76	73.64±1.7673.64±1.76
88	CL04-30DCL04-30D	24.24±1.2124.24±1.21	00	52.33±2.8252.33±2.82	72.33±0.8272.33±0.82
99	CL04-30ECL04-30E	1.52±0.621.52±0.62	39.78±8.4939.78±8.49	21.00±0.6421.00±0.64	20.00±4.6420.00±4.64
1010	CL04-30FCL04-30F	2.51±0.572.51±0.57	29.78±3.4329.78±3.43	22.00±3.6422.00±3.64	30.00±3.6330.00±3.63
1111	CL04-35BCL04-35B	22.78±0.8622.78±0.86	43.81±1.2343.81±1.23	76.75±0.4976.75±0.49	76.75±0.4976.75±0.49
1212	CL04-35DCL04-35D	12.43±0.9512.43±0.95	20.95±2.8820.95±2.88	52.78±1.6452.78±1.64	82.78±0.6482.78±0.64
1313	CL04-35ACL04-35A	16.02±3.8716.02±3.87	16.51±2.2316.51±2.23	32.38±2.5432.38±2.54	33.38±5.5433.38±5.54
1414	Gxf01-43AGxf01-43A	23.48±0.4523.48±0.45	39.94±1.0639.94±1.06	22.52±3.4222.52±3.42	21.52±3.4121.52±3.41
1515	Znl01-19CZnl01-19C	4.62±0.554.62±0.55	1.33±0.311.33±0.31	56.96±1.4956.96±1.49	76.96±0.4976.96±0.49
1616	Znl01-19AZnl01-19A	14.96±3.0814.96±3.08	2.22±0.952.22±0.95	53.80±3.2453.80±3.24	73.80±4.2473.80±4.24
1717	Znl01-19BZnl01-19B	9.79±0.719.79±0.71	2.67±0.622.67±0.62	20.20±2.6420.20±2.64	20.00±4.6420.00±4.64
1818	Znl01-19EZnl01-19E	1.52±0.621.52±0.62	70.16±5.5770.16±5.57	49.75±2.1349.75±2.13	79.75±6.1379.75±6.13
1919	Znl01-19DZnl01-19D	26.63±0.4726.63±0.47	0.000.00	35.42±1.9935.42±1.99	45.42±0.9945.42±0.99
2020	Znl01-19FZnl01-19F	1.52±0.621.52±0.62	50.16±5.5750.16±5.57	49.75±2.1349.75±2.13	59.75±6.1359.75±6.13
21twenty one	CL04-00CL04-00	27.32±1.2427.32±1.24	20.68±2.1020.68±2.10	26.30±2.4726.30±2.47	20.34±2.1620.34±2.16
22twenty two	宁南霉素Ningnanmycin	74.10±2.0474.10±2.04	--	--	--
23twenty three	TDLTDL	--	--	--	65.00±2.0065.00±2.00
24twenty four	BTHBTH	--	--	78.10±0.5478.10±0.54	78.00±1.3478.00±1.34
2525	SZG-7SZG-7	--	--	--	79.00±2.2779.00±2.27
2626	病毒唑Ribavirin	--	78.00±1.0078.00±1.00	--	--

表4 本发明的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ防治黄瓜白粉病的活性Table 4 Activity of thiadiazolyl ether methoxy acrylate derivative IV of the present invention for controlling cucumber powdery mildew

表5 本发明的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ防治黄瓜霜霉病的活性Table 5 Activity of thiadiazolyl ether methoxy acrylate derivative IV of the present invention for controlling cucumber downy mildew

工业实用性Industrial applicability

本发明提供一类噻二唑肟醚甲氧基丙烯酸酯衍生物。本发明所述的衍生物能够调控农业、园艺和卫生以及林业植物害虫和植物病原物的生物活性，可用于农业领域、园艺领域、林业领域杀虫、杀螨、杀菌、抗植物病毒、诱导植物产生抗病性，具有较好的经济价值和应用前景。 The present invention provides a class of thiadiazolone methoxy acrylate derivatives. The derivative of the invention can regulate the biological activity of agricultural, horticultural and sanitary and forestry plant pests and plant pathogens, and can be used in agriculture, horticulture, forestry, insecticide, acaricidal, bactericidal, anti-plant virus, induced plant It has disease resistance and has good economic value and application prospects.

Claims

一类噻二唑肟醚甲氧基丙烯酸酯衍生物，其特征在于具有如式Ⅳ所示的化学结构通式：A class of thiadiazolidine methoxy acrylate derivatives characterized by having the chemical structural formula shown in Formula IV:

其中，R¹选自：4-甲基-1,2,3-噻二唑-5-基、5-甲基-1,2,3-噻二唑-4-基；R²选自：甲基、氢；R³选自：1,2-二氟乙基、炔丙基、环丙基、甲基、1-甲硫基-2-甲基丙-2-基、(R)-1-甲硫基丙-2-基；X选自：氧、氮,n＝1,2；Z选自：碳、氮。Wherein R ^{1 is} selected from the group consisting of: 4-methyl-1,2,3-thiadiazol-5-yl, 5-methyl-1,2,3-thiadiazol-4-yl; and R ^{2 is} selected from the group consisting of: Methyl, hydrogen; R ^{3 is} selected from: 1,2-difluoroethyl, propargyl, cyclopropyl, methyl, 1-methylthio-2-methylpropan-2-yl, (R)- 1-Methylthiopropan-2-yl; X is selected from the group consisting of: oxygen, nitrogen, n = 1, 2; Z is selected from the group consisting of carbon and nitrogen.
权利要求1所述的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ的合成方法，具体合成路线为：The method for synthesizing the thiadiazolyl ether methoxy acrylate derivative IV according to claim 1, wherein the specific synthetic route is:

其中，R¹选自：4-甲基-1,2,3-噻二唑-5-基、5-甲基-1,2,3-噻二唑-4-基；R²选自：甲基、氢；R³选自：1,2-二氟乙基、炔丙基、环丙基、甲基、1-甲硫基-2-甲基丙-2-基、(R)-1-甲硫基丙-2-基；X选自：氧、氮,n＝1,2；Z选自：碳、氮。Wherein R ^{1 is} selected from the group consisting of: 4-methyl-1,2,3-thiadiazol-5-yl, 5-methyl-1,2,3-thiadiazol-4-yl; and R ^{2 is} selected from the group consisting of: Methyl, hydrogen; R ^{3 is} selected from: 1,2-difluoroethyl, propargyl, cyclopropyl, methyl, 1-methylthio-2-methylpropan-2-yl, (R)- 1-Methylthiopropan-2-yl; X is selected from the group consisting of: oxygen, nitrogen, n = 1, 2; Z is selected from the group consisting of carbon and nitrogen.
根据权利要求2所述的合成方法，其特征在于，所述的噻二唑肟醚甲氧基丙烯酸酯衍生物的合成方法分为以下步骤：The method according to claim 2, wherein the method for synthesizing the thiadiazolone methoxy acrylate derivative is divided into the following steps:

A.化合物Ⅱ的制备：A. Preparation of Compound II:

在反应瓶中用乙醇将化合物I溶解，加入取代1,2,3-噻二唑羰基化合物，然后向反应体系中滴加盐酸，室温搅拌，反应完全后减压除去溶剂，将残余物纯化，制得化合物Ⅱ；其中，所述1,2,3-噻二唑羰基化合物选自：4-甲基-1,2,3-噻二唑-5-甲醛、4-甲基-1,2,3-噻二唑-5-乙酮、5-甲基-1,2,3-噻二唑-4-甲醛、5-甲基-1,2,3-噻二唑-4-乙酮；The compound I is dissolved in ethanol in a reaction flask, and the substituted 1,2,3-thiadiazole carbonyl compound is added. Then, hydrochloric acid is added dropwise to the reaction system, and the mixture is stirred at room temperature. After the reaction is completed, the solvent is removed under reduced pressure, and the residue is purified. Preparing compound II; wherein the 1,2,3-thiadiazole carbonyl compound is selected from the group consisting of: 4-methyl-1,2,3-thiadiazole-5-formaldehyde, 4-methyl-1,2 , 3-thiadiazol-5-ethanone, 5-methyl-1,2,3-thiadiazole-4-carbaldehyde, 5-methyl-1,2,3-thiadiazole-4-ethyl ketone ;

B.化合物Ⅲ的制备:B. Preparation of Compound III:

在反应瓶中用甲醇将化合物Ⅱ溶解，然后向反应体系中加入氢氧化钠，然后加热回流，反应完全后将反应液浓缩，残余物用乙酸乙酯稀释，再加入水将残余物溶解，分离出水层，水层用盐酸调节pH至3，然后用乙酸乙酯萃取，将有机层用饱和氯化钠洗，无水硫酸钠干燥，抽滤，减压除去溶剂，制得化合物Ⅲ；The compound II was dissolved in methanol in a reaction flask, and then sodium hydroxide was added to the reaction system, followed by heating to reflux. After the reaction was completed, the reaction mixture was concentrated, and the residue was diluted with ethyl acetate. The effluent layer, the aqueous layer is adjusted to pH 3 with hydrochloric acid, and then extracted with ethyl acetate. The organic layer is washed with saturated sodium chloride, dried over anhydrous sodium sulfate, filtered,

C.化合物Ⅳ的制备: C. Preparation of Compound IV:

在反应瓶中用干燥的二氯甲烷将化合物Ⅲ溶解，然后向反应中加入EDCI和HOBT，加完之后室温搅拌，然后向反应体系中加入R³-XH_n，n＝1,2；室温搅拌，反应结束后，反应液用水洗，分离出有机层，有机层分别用饱和碳酸氢钠和饱和氯化钠洗后，无水硫酸钠干燥，抽滤，减压除去溶剂，将残余物纯化，即得到化合物Ⅳ。In the reaction flask, the compound III was dissolved in dry dichloromethane, and then EDCI and HOBT were added to the reaction. After the addition, the mixture was stirred at room temperature, and then R ³ -XH _n , n = 1, 2 was added to the reaction system; After the reaction, the reaction mixture was washed with water, and the organic layer was evaporated. That is, compound IV is obtained.
权利要求1所述的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ在制备杀菌剂、抗烟草花叶病毒剂或植物激活剂中的用途。Use of the thiadiazolyl ether methoxy acrylate derivative IV according to claim 1 for the preparation of a bactericide, a tobacco mosaic virus agent or a plant activator.
权利要求4所述的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ与农业上可接受的助剂在制备杀菌剂、抗烟草花叶病毒剂或植物激活剂中的用途。Use of the thiadiazolyl ether methoxy acrylate derivative IV according to claim 4 and an agriculturally acceptable adjuvant for the preparation of a bactericide, a tobacco mosaic virus agent or a plant activator.
权利要求1所述的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ在防治农业和林业以及园艺植物虫害中的用途。Use of the thiadiazolyl ether methoxy acrylate derivative IV according to claim 1 for controlling agricultural and forestry and horticultural plant pests.
根据权利要求6所述的用途，其特征在于，所述噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ与农业化学品共同施用；优选地，所述农业化学品选自：杀虫剂、杀菌剂、抗植物病毒剂、杀螨剂中的一种或几种。The use according to claim 6, wherein the thiadiazolone methoxy acrylate derivative IV is co-administered with an agricultural chemical; preferably, the agricultural chemical is selected from the group consisting of insecticides, One or more of a bactericide, an anti-plant virus agent, and an acaricide.
根据权利要求6或7所述的用途，其特征在于，所述的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ与所述杀虫剂中的任意一种或两种组合形成杀虫组合物用于防治农业和林业以及园艺植物虫害；The use according to claim 6 or 7, wherein the thiadiazolone methoxy acrylate derivative IV is combined with any one or both of the insecticides to form a pesticidal combination Used to control agricultural and forestry and horticultural plant pests;

优选地，所述杀虫剂选自：毒死蜱、地亚哝、啶虫脒、甲氨基阿维菌素、弥拜菌素、阿维菌素、多杀菌素、氰戊菊酯、高效氰戊菊酯、氯氰菊酯、高效氯氰菊酯、三氟氯氰菊酯、溴氰菊酯、甲氰菊酯、Beta-氟氯氰菊酯、Lambda-三氟氯氰菊酯、二氯苯醚菊酯、苄氯菊酯、丙烯菊酯、联苯菊酯、氯菊酯、醚菊酯、氟氯苯菊酯、氯氟胺氰戊菊酯、吡虫啉、烯啶虫胺、氯噻啉、噻虫啉、噻虫嗪、噻虫胺、呋虫胺、可尼丁、达特南、除虫脲、灭幼脲、伏虫隆、除虫隆、氟铃脲、氟虫脲、啶虫隆、虱螨脲、毒虫脲、氟幼脲、Noviflumuron即多氟脲，其CAS号为121451-02-3、氟螨脲、Novaluron即双苯氟脲、氟啶脲、Bay sir6874即{1-[(3.5-二氯-4)4-硝基苯氧基苯基3-3-(2-氯苯)-脲}、Bay SIR-8514即[1-(4-三氟甲氧基苯基)-3-(2-氯苯)-脲]、嗪虫脲、Bistrifluron即双三氟虫脲、呋喃虫酰肼、虫酰肼、氯虫酰肼、甲氧虫酰肼、环虫酰肼、乐果、氧化乐果、敌敌畏、乙酰甲胺磷、***磷、喹硫磷、哒嗪硫磷、氯唑磷、叶蝉散、西维因、抗蚜威、速灭威、异丙威、杀螟丹、仲丁威、叶飞散、甲萘威、丙硫克百威、丁硫克百威、杀螟丹、溴螨酯、噻螨酮、唑螨酯、哒螨酮、四螨嗪、炔螨特、丁醚脲、吡蚜酮、螺螨酯、螺虫酯、螺虫乙酯、丁烯氟虫腈、***锡、噻嗪酮、灭线磷、氟虫腈、杀虫单、杀虫双、氯虫酰胺、氟虫酰胺、氟氰虫酰胺、氰虫酰胺、唑虫酰胺、溴虫腈、吡嗪酮、乙螨唑、吡螨胺、哒幼酮、吡丙醚、埃玛菌素；Preferably, the insecticide is selected from the group consisting of: chlorpyrifos, scorpion guanidine, acetamiprid, emamectin, imipenem, avermectin, spinosyn, fenvalerate, high-efficiency acetonide Pyrethroid, cypermethrin, beta-cypermethrin, cyhalothrin, deltamethrin, fenpropathrin, Beta-cyfluthrin, Lambda-cyhalothrin, permethrin, permethrin, methrin, hydrazine Pyrethrin, permethrin, fenthrin, flumethrin, flufenacetate, imidacloprid, nitenpyram, chlorothiazide, thiacloprid, thiamethoxam, clothianidin, fur Nicotinamide, cotinine, Dartnam, diflubenzuron, chlorbenzuron, flubenzuron, chlorfenapyr, hexaflumuron, flubenzuron, acetamiprid, guanidine, chlorpyrifos, flubenzuron, Noviflumuron is a polyfluorourea with a CAS number of 121451-02-3, fluoroquinone urea, Novaluron, ie, diphenylfluorourea, chlorfluazuron, Bay sir6874, ie {1-[(3.5-dichloro-4)4-nitro Phenoxyphenyl 3-3-(2-chlorophenyl)-urea}, Bay SIR-8514 is [1-(4-trifluoromethoxyphenyl)-3-(2-chlorophenyl)-urea] , oxazide, Bistrifluron, bis-trifluoroidazolium, furanyl hydrazide, tebufenozide, Chloramphenic acid hydrazide, methoxyfenhydrazide, chlorfenapyr, dimethoate, omethoate, dichlorvos, acephate, triazophos, quetiapine, pyridazin, chlorpyrifos, leaching , Xiweiyin, Kangwei, Kuweiwei, Weiweiwei, Zhidan, Zhongdingwei, Yefeisan, Jia Naiwei, propyl thiocarbamate, butyl thiocarb, chlorpyrifos, bromine Ester, thiazolone, oxazolidine, anthrone, tetrazine, alkyne, dibutyl ether, pyridinium Ketone, snail ester, spirotetramat, spirotetraethyl ester, butene fipronil, triazole tin, buprofezin, chlorpyrifos, fipronil, insecticidal, insecticidal, chlorantranilidamide, fluorine Insectamide, fluocyanamide, cyanamide, oxazolamide, chlorfenapyr, pyrazinone, etoxazole, pyridoxamine, ketone, pyriproxyfen, emamectin;

优选地，所述的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ在所述杀虫组合物中的质量百分含量是1％-90％；Preferably, the thiadiazolium ether methoxy acrylate derivative IV is present in the pesticidal composition in an amount of from 1% to 90% by mass;

优选地，所述的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ与所述杀虫剂的比例为质量百分比1％∶99％到99％∶1％；Preferably, the ratio of the thiadiazolone methoxy acrylate derivative IV to the insecticide is 1% by mass: 99% to 99%: 1% by mass;

优选地，所述杀虫组合物加工的剂型选自：种子处理乳剂、水乳剂、微乳剂、悬乳剂、胶囊悬浮剂、水溶性粒剂、细粒剂、可溶性浓剂、毒谷、块状毒饵、粒状毒饵、片状毒饵、浓毒饵、缓释块、静电喷雾剂、水包油乳剂、烟雾罐、烟雾烛、烟雾筒、烟雾棒、烟雾片、烟雾丸、发气剂、油膏、热雾剂、冷雾剂、气雾剂、固/液混合装剂、液/液混合装剂、固/固混合装剂、药漆、微粒剂、追踪粉剂、油悬剂、油分散性粉剂、浓胶剂、泼浇剂、种衣剂、涂抹剂、成膜油剂、超低容量液剂、蒸汽释放剂；Preferably, the dosage form processed by the pesticidal composition is selected from the group consisting of: seed treatment emulsion, water emulsion, microemulsion, suspoemulsion, capsule suspension, water-soluble granule, fine granule, soluble concentrate, poisonous valley, lumps Bait, granular bait, flake bait, concentrated bait, slow release block, electrostatic spray, oil-in-water emulsion, smoke can, smoke candle, smoke tube, smoke stick, smoke sheet, smoke pill, gas generator, ointment, Hot mist, cold spray, aerosol, solid/liquid mixed charge, liquid/liquid mixed charge, solid/solid mixed charge, lacquer, microparticle, trace powder, oil suspension, oil dispersible powder , thickener, pouring agent, seed coating agent, smear agent, film forming oil agent, ultra low volume liquid agent, steam release agent;

优选地，所述杀虫组合物防治的植物虫害选自：红蜘蛛、东亚飞蝗、云斑车蝗、中华稻蝗、日本黄脊蝗、单刺蝼蛄、东方蝼蛄、稻蓟马、烟蓟马、温室蓟马、稻管蓟马、麦简管蓟马、温室白粉虱、烟粉虱、黑尾叶蝉、大青叶蝉、棉叶蝉、斑衣蜡蝉、褐飞虱、白背飞虱、灰飞虱、甘蔗扁角飞虱、棉蚜、麦二叉蚜、麦长管蚜、桃蚜、高粱蚜、萝卜蚜、吹绵蚧、桑盾蚧、矢尖盾蚧、梨圆蚧、白蜡虫、红蜡蚧、朝鲜球坚蚧、梨网蝽、香蕉网蝽、细角花蝽、微小花蝽、针缘蝽、稻蛛缘蝽、稻褐蝽、稻黑蝽、稻绿蝽、绿盲蝽、苜蓿盲蝽、中黑盲蝽、大草蛉、丽草蛉、中华草蛉、谷蛾、衣蛾、黄刺蛾、褐刺蛾、扁刺蛾、麦蛾、棉红铃虫、甘薯麦蛾、小菜蛾、桃小食心虫、大豆食心虫、桃小食心虫、苹果顶梢卷叶蛾、褐带长卷叶蛾、拟小黄卷叶蛾、二化螟、豆荚螟、玉米螟、三化螟、菜螟、稻纵卷叶螟、条螟、棉卷叶野螟、桃蛀螟、黏虫、斜纹夜蛾、稻螟蛉、棉小造桥虫、甜菜夜蛾、大螟、棉铃虫、鼎点金刚钻、小地老虎、大地老虎、黄地老虎、盗毒蛾、舞毒蛾、甘薯天蛾、豆天蛾、直纹稻弄蝶、隐纹谷弄蝶、柑橘凤蝶、玉带凤蝶、菜粉蝶、苎麻赤蛱蝶、苎麻黄蛱蝶、豆芫菁、金星步甲、皱鞘步甲、麦穗步甲、沟金针虫、细胸金针虫、谷斑皮蠹、黑皮蠹、柑橘小吉丁虫、金缘吉丁虫、黄粉虫、黑粉虫、赤拟谷盗、杂拟谷盗、铜绿异丽金龟、暗黑金龟、华北大黑鳃金龟、桑天牛、星天牛、橘褐天牛、桃红颈天牛、大猿叶虫、小猿叶虫、黄守瓜、黄曲条跳甲、绿豆象、豌豆象、蚕豆象、玉米象、米象、小麦叶蜂、梨实蜂、黄带姬蜂、黏虫白星姬蜂、螟蛉悬茧姬蜂、棉铃虫齿唇姬蜂、螟黑点疣姬蜂、蚊、蝇、虻、麦红吸浆虫、麦黄吸浆虫、稻瘿蚊、柑橘大实蝇、瓜实蝇、麦叶灰潜蝇、美洲斑潜蝇、豆秆黑潜蝇、麦秆蝇、种蝇、葱蝇、萝卜蝇、伞裙追寄蝇、玉米螟厉寄蝇、黏虫；Preferably, the plant pests controlled by the insecticidal composition are selected from the group consisting of: red spider, oriental planthopper, cloud locust, Chinese rice blast, Japanese yellow ridge, single locust, oriental carp, rice locust, and tobacco Horse, greenhouse thrips, rice tube thrips, wheat tube horses, greenhouse whitefly, whitefly, black-tailed leafhopper, big green leafhopper, cotton leafhopper, spotted waxhopper, brown planthopper, white-backed planthopper , Laodelphax striatellus, sugarcane, flat-horned corn fly, cotton aphid, wheat bifurcation, wheat long tube, peach aphid, sorghum, radish, blown, sang shield, yam shield, pear round, White wax insects, red wax mites, Korean ball glutinous rice, pear net mites, banana net mites, fine-horned flower buds, tiny flower buds, needle-edge mites, rice spider mites, rice brown mites, rice black mites, rice green mites, Green-spotted scorpion, scorpion scorpion, black-spotted scorpion, large grass scorpion, cypress, Chinese grass scorpion, valley moth, clothing moth, yellow thorn moth, brown thorn moth, spur moth, wheat moth, cotton bollworm, Sweet potato moth, diamondback moth, peach small heartworm, soybean heartworm, peach small heartworm, apple tip leaf moth, brown leaf moth, pseudo-small leaf moth, stem borer, bean pod Corn borer, stem borer, rapeseed meal, rice leaf roller, barley, cotton leaf bark, peach aphid, armyworm, Spodoptera litura, rice bran, cotton small bridgeworm, beet armyworm, giant salamander , cotton bollworm, Ding Ding diamond, small tiger, earth tiger, yellow tiger, poisonous moth, gypsy moth, sweet potato hawk moth, bean hawk moth, straight grain rice butterfly, cryptic valley butterfly, citrus swallow butterfly, jade belt Swallowtail butterfly, cabbage butterfly, ramie red butterfly, ramie butterfly, bean phthalocyanine, Venus carapace, wrinkle sheath, armor, wheat burdock, echinoderma, scutellaria, variegata, black skin蠹, citrus small jiding insects, Jinyuan jiding insects, yellow mealworms, black mealworms, red worms, miscellaneous pirates, patina, golden tortoises, dark golden tortoises, North China black scorpion, sangtian cattle, star days Cow, orange brown beetle, peach red neck beetle, big leafhopper, small leafhopper, yellow guard, Yellow-curved beetle, mung bean, pea, broad bean, corn, rice, wheat leaf bee, pear bee, yellow belt wasp, sticky insect white star bee, cockroach cockroach, cotton bollworm tooth Iguana, cockroach, cockroach, cockroach, fly, cockroach, cockroach, larvae, larvae, rice blast, citrus fruit fly, melon fly, larvae, larvae, stalk Black-spotted fly, wheat stalk fly, seed fly, onion fly, radish fly, umbrella skirt chasing fly, corn scorpion fly, sticky insect;

优选地，所述杀虫组合物防治的植物选自：稻谷、小麦、大麦、燕麦、玉米、高粱、甘薯、马铃薯、木薯、大豆、荷兰豆、蚕豆、豌豆、绿豆、小豆、棉花、蚕桑、花生、油菜、芝麻、向日葵、甜菜、甘蔗、咖啡、可可、人参、贝母、橡胶、椰子、油棕、剑麻、烟草、番茄、辣椒、萝卜、黄瓜、白菜、芹菜、榨菜、甜菜、油菜、葱、大蒜、西瓜、甜瓜、哈密瓜、木瓜、苹果、柑桔和桃树、茶、山野菜、竹笋、啤酒花、胡椒、香蕉、番木瓜、兰花、盆景。Preferably, the plant controlled by the pesticidal composition is selected from the group consisting of: rice, wheat, barley, oats, corn, sorghum, sweet potato, potato, tapioca, soybean, pea, broad bean, pea, mung bean, adzuki bean, cotton, sericulture, peanut , rapeseed, sesame, sunflower, beet, sugar cane, coffee, cocoa, ginseng, fritillary, rubber, coconut, oil palm, sisal, tobacco, tomato, pepper, radish, cucumber, cabbage, celery, mustard, beet, rape, Onions, garlic, watermelon, melon, cantaloupe, papaya, apple, citrus and peach, tea, wild vegetables, bamboo shoots, hops, pepper, banana, papaya, orchid, bonsai.
根据权利要求6或7所述的用途，其特征在于，所述的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ与所述杀菌剂中的任意一种或两种组合形成杀菌组合物用于防治农业和林业以及园艺植物病害；The use according to claim 6 or 7, wherein the thiadiazolyl ether methoxy acrylate derivative IV is combined with any one or both of the bactericides to form a bactericidal composition. For the control of agricultural and forestry and horticultural plant diseases;

优选地，所述杀菌剂选自：苯并噻二唑、噻酰菌胺，简写为TDL、噻酰胺、甲噻诱胺、4-甲基-1,2,3-噻二唑-5-甲酸、4-甲基-1,2,3-噻二唑-5-甲酸钠、4-甲基-1,2,3-噻二唑-5-甲酸乙酯、DL-β-氨基丁酸、异噻菌胺，其英文通用名为：isotianil、3,4-二氯异噻唑-5-甲酸、3,4-二氯异噻唑-5-甲酸钠、3,4-二氯异噻唑-5-甲酸乙酯、病毒唑、安托芬、宁南霉素或水杨酸、霜脲氰、福美双、福美锌、代森锰锌、乙磷铝、甲基硫菌灵、百菌清、敌可松、腐霉利、苯锈啶、甲基托布津、托布津、精甲霜灵、氟吗啉、烯酰吗啉、高效甲霜灵、高效苯霜灵、双氯氰菌胺、磺菌胺、甲磺菌胺、噻氟菌胺、氟酰胺、叶枯酞、环丙酰菌胺、环氟菌胺、环酰菌胺、氰菌胺、硅噻菌胺、呋吡菌胺、吡噻菌胺、双炔酰菌胺、苯酰菌胺、甲呋酰胺、萎锈灵、乙菌利、异菌脲、嘧菌酯、醚菌胺、氟嘧菌酯、醚菌酯、苯氧菌胺、肟醚菌胺、啶氧菌酯、唑菌胺酯、肟菌酯、烯肟菌酯、烯肟菌胺、氧环唑、糠菌唑、环丙唑醇、苯醚甲环唑、烯唑醇、高效烯唑醇、氟环唑、腈苯唑、氟喹唑、氟硅唑、粉唑醇、己唑醇、亚胺唑、种菌唑、叶菌唑、腈菌唑、戊菌唑、丙环唑、丙硫菌唑、硅氟唑、戊唑醇、四氟醚唑、***醇、灭菌唑、联苯***醇、噻菌灵、麦穗宁、抑霉唑、高效抑霉唑、咪鲜胺、氟菌唑、氰霜唑、咪唑菌酮、噁咪唑、稻瘟酯、噁唑菌酮、啶菌噁唑、噁霉灵、噁霜灵、噻唑菌胺、土菌灵、辛噻酮、苯噻硫氰、十二环吗啉、丁苯吗啉、十三吗啉、拌种咯、咯菌腈、氟啶胺、啶斑肟、环啶菌胺、啶酰菌胺、氟啶酰菌胺、啶菌胺、嘧菌环胺、氟嘧菌胺、嘧菌腙、嘧菌胺、嘧霉胺、氯苯嘧啶醇、氟苯嘧啶醇、灭螨猛、二氰蒽醌、乙氧喹啉、羟基喹啉、丙氧喹啉、苯氧喹啉、乙霉威、异丙菌胺、苯噻菌胺、霜霉威、磺菌威、敌瘟磷、异稻瘟净、吡菌磷、甲基立枯磷、灭瘟素、春雷霉素、多抗霉素、多氧霉素、有效霉素、井冈霉素、链霉素、甲霜灵、呋霜灵、苯霜灵、呋酰胺、灭锈胺、多菌灵、苯菌灵、甲基硫菌灵、***酮、乙嘧酚磺酸酯、二甲嘧酚、乙嘧酚、敌菌丹、克菌丹、灭菌丹、乙烯菌核利、氟氯菌核利、菌核净、百菌清、稻瘟灵、稻瘟净、叶枯唑、五氯硝基苯、丙森锌、三乙膦酸铝、硫磺、波尔多液、硫酸铜、氧氯化铜、氧化亚铜、氢氧化铜、苯菌酮、戊菌隆、哒菌酮、四氯苯酞、咯喹酮、螺环菌胺、三环唑、嗪胺灵、多果啶、双胍辛盐、双胍辛胺、氯硝胺、苯磺菌胺、甲苯磺菌胺、吲哚酯、敌磺钠、喹菌酮、烯丙苯噻唑、溴硝醇、碘甲烷、威百亩、敌线酯、棉隆、二氯异丙醚、噻唑磷、硫线磷、丰索磷、虫线磷、苯线磷、灭线磷、除线磷、氯唑磷、丁硫环磷、杀线威、涕灭威、克百威、硫酰氟、二氯丙烯、二氯异烟酸、烯丙异噻唑；Preferably, the bactericide is selected from the group consisting of: benzothiadiazole, thiazide, abbreviated as TDL, thiazamide, methyl thiazide, 4-methyl-1,2,3-thiadiazole-5- Formic acid, sodium 4-methyl-1,2,3-thiadiazol-5-carboxylate, ethyl 4-methyl-1,2,3-thiadiazol-5-carboxylate, DL-β-aminobutyric acid, Isotianil, its common name in English is: isotianil, 3,4-dichloroisothiazol-5-carboxylic acid, 3,4-dichloroisothiazol-5-formate, 3,4-dichloroisothiazol-5- Ethyl formate, ribavirin, antofin, nymidine or salicylic acid, cymoxanil, thiram, thiram, mancozeb, ethylphosphoric acid, thiophanate, chlorothalonil, enemy Cortisone, procymidone, benzopyridin, methyl thiophanate, thiophanate, refined metalaxyl, flumorph, enoylmorpholine, high-performance metalaxyl, high-efficiency benzoxanthin, chloramphenicol, sulfonate Bismuthamide, mesalamide, thifluzamide, fluamide, leaf cumin, cyclopropionamide, cycloflufenamide, fenhexamid, cyanamide, thiastrobin, flufenamide, Pentimidamide, dipropiylamide, benzilamide, mefenamide, wilting, etoxin, iprodione, azoxystrobin, fenfluramine, fluoxastrobin Epoxystrobin, phenoxystrobin, difloxacin, picoxystrobin, pyraclostrobin, trifloxystrobin, enestrobin, enestrobin, oxycyclazole, carbendazole, cyproconazole , difenoconazole, diniconazole, high-efficiency diniconazole, epoxiconazole, nitrile azole, fluoroquinazole, flusilazole, fluconazole, hexaconazole, imidazole, inocastazole, leaf fungus Azole, myclobutanil, penconazole, propiconazole, prothioconazole, silicon fluoride, tebuconazole, tetrafluoroetherazole, triazole alcohol, sterilized azole, biphenyl triazole alcohol, thiabendazole, Maisuining, imazalil, high-efficiency imazalil, prochloraz, fluconazole, cyanoxazole, imidazolone, moxalimid, rice sterol ester, famoxadone, pyridine oxazole, carbendazim, Ointment, ethaboxam, carbendazim, octyl ketone, thiothiazide, dodecaline morpholine, butyl morpholine, thirteen morpholine, seed dressing, fludioxonil, fluazinam, pyridine Spot 肟, Cyclohexillin, boscalid, fluazirid, acesulfame, cyprodinil, fluzalazine, azoxystrobin, azoxystrobin, pyrimethanil, chlorpyrimidine, fluoride Pyrimidine alcohol, chlorpyrifos, dicyanoquinone, ethoxyquin, quinolin, propoxyquinoline, phenoxyquinoline, carbendazim, isopropylidene, phenothiamine, propamocarb, Sulfapredil, enemies, diarrhea, pyridoxine, methyl chlorfen, quercetin, geranol, polymycin, polyoxymycin, tyrosin, jinggangmycin, chain Neomycin, metalaxyl, furosemide, benzathine, furfuramide, rust-eliminating amine, carbendazim, benomyl, thiophanate-methyl, triadimefon, acetaminophen sulfonate, Phenol, acetazol, diclofenac, captan, sterilized dan, vinyl nucleus, chlorhexidine nucleus, sclerotium net, chlorothalonil, indigo, rice glutinous rice, leaf azole, five Chloronitrobenzene, propidium zinc, aluminum triethylphosphinate, sulfur, Bordeaux solution, copper sulfate, copper oxychloride, cuprous oxide, copper hydroxide, benomyl, pentosan, chlorfenone, tetrachloro Benzoquinone, praziquantel, spirocyclammine, tricyclazole, pyrazinamide Polyglycosidine, biguanide salt, bis-octylamine, chloramine, sulfonamide, toluidine, oxime ester, sodium sulfonate, quinoflazer, allyl benzothiazole, bronopol, methyl iodide, Weibaimu, enemy line ester, cotton sulphate, dichloroisopropyl ether, thiazolyl phosphorus, sulphur phosphorus, phosporin, insect phosphorus, benzene phosphorus, phosphine, phosphorus removal, chlorpyrifos, butyl sulphide Cyclophosphamide, chlorpyrifos, aldicarb, carbofuran, sulfuryl fluoride, dichloropropene, dichloroisonicotinic acid, allylisothiazole;

优选地，所述的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ在所述杀菌组合物中的总的质量百分含量是1％-90％；Preferably, the total mass percentage of the thiadiazolyl ether methoxy acrylate derivative IV in the germicidal composition is from 1% to 90%;

优选地，所述的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ与所述杀菌剂的比例为质量百分比1％∶99％到99％∶1％；Preferably, the ratio of the thiadiazolone methoxy acrylate derivative IV to the bactericide is 1% by mass: 99% to 99%: 1% by mass;

优选地，所述杀菌组合物加工的剂型选自：种子处理乳剂、水乳剂、微乳剂、悬乳剂、胶囊悬浮剂、水溶性粒剂、细粒剂、可溶性浓剂、毒谷、块状毒饵、粒状毒饵、片状毒饵、浓毒饵、缓释块、静电喷雾剂、水包油乳剂、烟雾罐、烟雾烛、烟雾筒、烟雾棒、烟雾片、烟雾丸、发气剂、油膏、热雾剂、冷雾剂、气雾剂、固/液混合装剂、液/液混合装剂、固/固混合装剂、药漆、微粒剂、追踪粉剂、油悬剂、油分散性粉剂、浓胶剂、泼浇剂、种衣剂、涂抹剂、成膜油剂、超低容量液剂、蒸汽释放剂；Preferably, the bactericidal composition is processed in a dosage form selected from the group consisting of: seed treatment emulsion, water emulsion, microemulsion, suspoemulsion, capsule suspension, water-soluble granule, fine granule, soluble concentrate, poisonous valley, block bait , granular bait, flake bait, concentrated bait, slow release block, electrostatic spray, oil-in-water emulsion, smoke can, smoke candle, smoke tube, smoke stick, smoke sheet, smoke pill, gas generator, ointment, heat Spray, cold spray, aerosol, solid/liquid mixed charge, liquid/liquid mixed charge, solid/solid mixed charge, lacquer, microparticle, trace powder, oil suspension, oil dispersible powder, Thickener, pouring agent, seed coating agent, smear agent, film forming oil agent, ultra low volume liquid agent, steam release agent;

优选地，所述杀菌组合物防治的植物病害选自：稻苗绵腐病、番茄根腐病、马铃薯晚疫病、烟草黑胫病、谷子白粉病、葡萄霜霉病、莴苣霜霉病、黄瓜霜霉病、黄瓜炭疽病；Preferably, the plant disease controlled by the bactericidal composition is selected from the group consisting of: rice seedling cotton rot, tomato root rot, potato late blight, tobacco black shank, millet powdery mildew, grape downy mildew, lettuce downy mildew, cucumber Downy mildew, cucumber anthracnose;

优选地，所述杀菌组合物适用的植物选自：稻谷、小麦、大麦、燕麦、玉米、高粱、甘薯、马铃薯、木薯、大豆、荷兰豆、蚕豆、豌豆、绿豆、小豆、棉花、蚕桑、花生、油菜、芝麻、向日葵、甜菜、甘蔗、咖啡、可可、人参、贝母、橡胶、椰子、油棕、剑麻、烟草、番茄、辣椒、萝卜、黄瓜、白菜、芹菜、榨菜、甜菜、油菜、葱、大蒜、西瓜、甜瓜、哈密瓜、木瓜、苹果、柑桔和桃树、茶、山野菜、竹笋、啤酒花、胡椒、香蕉、番木瓜、兰花、盆景。Preferably, the bactericidal composition is suitable for plants selected from the group consisting of: rice, wheat, barley, oats, corn, sorghum, sweet potato, potato, cassava, soybean, pea, broad bean, pea, mung bean, adzuki bean, cotton, sericulture, peanut, Rape, sesame, sunflower, beet, sugar cane, coffee, cocoa, ginseng, fritillary, rubber, coconut, Oil palm, sisal, tobacco, tomato, pepper, radish, cucumber, cabbage, celery, mustard, beet, rape, onion, garlic, watermelon, melon, cantaloupe, papaya, apple, citrus and peach, tea, wild vegetables , bamboo shoots, hops, pepper, banana, papaya, orchid, bonsai.
根据权利要求6或7所述的用途，其特征在于，所述的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ与所述抗病毒药剂中的任意一种或两种组合形成抗病毒组合物用于防治农业和林业以及园艺植物病毒病害The use according to claim 6 or 7, wherein the thiadiazolone methoxy acrylate derivative IV is combined with any one or both of the antiviral agents to form an antiviral combination Used to control agricultural and forestry and horticultural plant virus diseases

优选地，所述抗病毒药剂选自：苯并噻二唑、噻酰菌胺，简写为TDL、异噻菌胺，其英文通用名为：isotianil、4-甲基-1,2,3-噻二唑-5-甲酸、4-甲基-1,2,3-噻二唑-5-甲酸钠、4-甲基-1,2,3-噻二唑-5-甲酸乙酯、3,4-二氯异噻唑-5-甲酸、3,4-二氯异噻唑-5-甲酸钠、3,4-二氯异噻唑-5-甲酸乙酯、DL-β-氨基丁酸、病毒唑、安托芬、宁南霉素、噻酰胺、甲噻诱胺或水杨酸、嘧肽霉素、二氯异烟酸、烯丙异噻唑、井冈羟胺、井冈霉素；Preferably, the antiviral agent is selected from the group consisting of: benzothiadiazole, thiazide, abbreviated as TDL, isotianil, and its common name in English is: isotianil, 4-methyl-1,2,3- Thiadiazole-5-carboxylic acid, sodium 4-methyl-1,2,3-thiadiazole-5-carboxylate, ethyl 4-methyl-1,2,3-thiadiazole-5-carboxylate, 3, 4-Dichloroisothiazol-5-carboxylic acid, 3,4-dichloroisothiazol-5-formate, 3,4-dichloroisothiazol-5-carboxylic acid ethyl ester, DL-β-aminobutyric acid, ribavirin, Antofin, ningnanmycin, thiazamide, methyl thiazide or salicylic acid, glutathione, dichloroisonicotinic acid, allylisothiazole, Jinggang hydroxylamine, Jinggangmycin;

优选地，所述的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ在所述抗病毒组合物中的总的质量百分含量是1％-90％；Preferably, the total mass percentage of the thiadiazolone methoxy acrylate derivative IV in the antiviral composition is from 1% to 90%;

优选地，所述的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ与所述抗植物病毒剂的比例为质量百分比1％∶99％到99％∶1％；Preferably, the ratio of the thiadiazolone methoxy acrylate derivative IV to the anti-plant virus agent is 1% by mass: 99% to 99%: 1% by mass;

优选地，所述抗病毒组合物加工的剂型选自：种子处理乳剂、水乳剂、微乳剂、悬乳剂、胶囊悬浮剂、水溶性粒剂、细粒剂、可溶性浓剂、毒谷、块状毒饵、粒状毒饵、片状毒饵、浓毒饵、缓释块、静电喷雾剂、水包油乳剂、烟雾罐、烟雾烛、烟雾筒、烟雾棒、烟雾片、烟雾丸、发气剂、油膏、热雾剂、冷雾剂、气雾剂、固/液混合装剂、液/液混合装剂、固/固混合装剂、药漆、微粒剂、追踪粉剂、油悬剂、油分散性粉剂、浓胶剂、泼浇剂、种衣剂、涂抹剂、成膜油剂、超低容量液剂、蒸汽释放剂；Preferably, the antiviral composition is processed in a dosage form selected from the group consisting of: seed treatment emulsion, water emulsion, microemulsion, suspoemulsion, capsule suspension, water-soluble granule, fine granule, soluble concentrate, poisonous valley, lumps Bait, granular bait, flake bait, concentrated bait, slow release block, electrostatic spray, oil-in-water emulsion, smoke can, smoke candle, smoke tube, smoke stick, smoke sheet, smoke pill, gas generator, ointment, Hot mist, cold spray, aerosol, solid/liquid mixed charge, liquid/liquid mixed charge, solid/solid mixed charge, lacquer, microparticle, trace powder, oil suspension, oil dispersible powder , thickener, pouring agent, seed coating agent, smear agent, film forming oil agent, ultra low volume liquid agent, steam release agent;

优选地，所述抗病毒组合物防治的病毒病害选自：水稻矮缩病、黄矮病、条纹叶枯病、番茄蕨叶病毒病、辣椒花叶病毒病、烟草脉坏死病毒病、玉米矮花叶病、花椰菜花叶病毒、柑橘病毒病、建兰花叶病毒、建兰环斑病毒；Preferably, the viral disease controlled by the antiviral composition is selected from the group consisting of rice dwarf disease, yellow dwarf disease, stripe leaf blight, tomato fern leaf virus disease, pepper mosaic virus disease, tobacco vein necrosis virus disease, corn dwarf Mosaic disease, cauliflower mosaic virus, citrus virus disease, broccoli virus, Jianlan ring spot virus;

优选地，所述抗病毒组合物用于防治的植物选自：稻谷、小麦、大麦、燕麦、玉米、高粱、甘薯、马铃薯、木薯、大豆、荷兰豆、蚕豆、豌豆、绿豆、小豆、棉花、蚕桑、花生、油菜、芝麻、向日葵、甜菜、甘蔗、咖啡、可可、人参、贝母、橡胶、椰子、油棕、剑麻、烟草、番茄、辣椒、萝卜、黄瓜、白菜、芹菜、榨菜、甜菜、油菜、葱、大蒜、西瓜、甜瓜、哈密瓜、木瓜、苹果、柑桔和桃树、茶、山野菜、竹笋、啤酒花、胡椒、香蕉、番木瓜、兰花、盆景。Preferably, the plant for controlling the antiviral composition is selected from the group consisting of: rice, wheat, barley, oats, corn, sorghum, sweet potato, potato, tapioca, soybean, pea, broad bean, pea, mung bean, adzuki bean, cotton, sericulture , peanuts, rapeseed, sesame, sunflower, beet, sugar cane, coffee, cocoa, ginseng, fritillary, rubber, coconut, oil palm, sisal, tobacco, tomato, pepper, radish, cucumber, cabbage, celery, mustard, beet, Rape, onion, garlic, watermelon, melon, cantaloupe, papaya, apple, citrus and peach, tea, wild vegetables, bamboo shoots, Hops, pepper, banana, papaya, orchid, bonsai.
根据权利要求6或7所述的用途，其特征在于，所述的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ与所述杀螨剂中的任意一种或两种组合形成杀螨组合物用于防治农业和林业以及园艺植物螨害；The use according to claim 6 or 7, wherein the thiadiazolone methoxy acrylate derivative IV is combined with any one or both of the acaricides to form a miticide combination Used to control agricultural and forestry and horticultural plant damage;

优选地，所述杀螨剂选自：***锡、三环锡、苯丁锡、三磷锡、毒虫畏、甲基毒虫畏、巴毒磷、敌敌畏、庚烯磷、速灭磷、久效磷、二溴磷、毒死蜱、嘧啶磷、氯甲亚胺硫磷、氧乐果、敌杀磷、乙硫磷、马拉硫磷、虫螨畏、伏杀硫磷、辛硫磷、甲基嘧啶硫磷、喹硫磷、治螟磷、***磷、蚜灭多、水胺硫磷、甲胺磷、胺丙畏、氯亚胺硫磷、亚胺硫磷、氟丙菊酯、联苯菊酯、氯氟氰菊酯、精高效氯氟氰菊酯、甲氰菊酯、氟氰戊菊酯、氟氯苯菊酯、氟胺氰菊酯、溴氟菊酯、联苯肼酯、苯硫威、涕灭威、丁酮威、杀线威、抗虫威、久效威、苯菌灵、氯灭杀威、克百威、丁硫克百威、速灭威、蜱虱威、伐虫脒、单甲脒、杀螨脒、双甲脒、杀虫脒、苯甲酸苄酯、溴螨酯、丁氟螨酯、灭螨醌、氟蚜螨、氟虫脲、浏阳霉素、虫螨霉素、苏云金素、杀螨素、浏阳霉素、阿维菌素、多拉菌素、埃普利诺菌素、伊维菌素、赛拉菌素、莫西菌素、除虫菊素、烟碱、苦参碱、印楝素、鱼藤酮、吡螨胺、哒螨酮、唑螨酯、四螨嗪、炔螨特、噻螨酮、螺螨酯、嘧螨酯、杀螨酯、克螨特、哒螨灵；Preferably, the acaricide is selected from the group consisting of: triazole tin, tricyclotin, phenbutyltin, triphosphorus, chlorpyrifos, methyl chlorpyrifos, phytophos, dichlorvos, heptene phosphorus, quick-killing phosphorus, long time Phosphorus, dibromophosphorus, chlorpyrifos, pyrimidine, chloromethylimine, omethoate, chlorpyrifos, ethion, malathion, worm, phoxim, phoxim, Pyrithione, quetiapine, strontium phosphate, triazophos, quenching, acesulfame, methamidophos, acesulfame, chloroimidate, imipenem, flumethrin, Bifenthrin, cyhalothrin, cyhalothrin, fenpropathrin, fluvalerate, flumethrin, fluvalinate, bifenthrin, biphenyl hydrazine Ester, phenylthiocarb, aldicarb, butanone, chlorpyrifos, anti-insect, long-acting, benomyl, chlorhexidine, carbofuran, butyl thiocarb, fast-acting, 蜱Converse, worm, monomethyl hydrazine, acaricidal, amitraz, chlorpyrifos, benzyl benzoate, bromo oxime ester, butyl fluoro ester, guanidine, fluoranthene, flubenzuron, Liuyang Neomycin, echinomycin, sulphate, acaricidin, liuyangmycin Avermectin, doramectin, eplenomycin, ivermectin, serramycin, moxidectin, pyrethrin, nicotine, matrine, azadirachtin, rotenone, pyridoxine Amine, anthrone, oxazolidine, tetrazine, alkyne, thiazolone, spirodecyl ester, pyridoxine, acaricidal ester, ketone, hydrazine;

优选地，所述的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ在所述杀螨组合物中的总的质量百分含量是1％-90％；Preferably, the total mass percentage of the thiadiazolone methoxy acrylate derivative IV in the acaricidal composition is from 1% to 90%;

优选地，所述的噻二唑肟醚甲氧基丙烯酸酯衍生物Ⅳ与所述杀螨剂的比例为质量百分比1％∶99％到99％∶1％；Preferably, the ratio of the thiadiazolone methoxy acrylate derivative IV to the acaricide is 1% by mass: 99% to 99%: 1% by mass;

优选地，所述杀螨组合物加工的剂型选自：种子处理乳剂、水乳剂、微乳剂、悬乳剂、胶囊悬浮剂、水溶性粒剂、细粒剂、可溶性浓剂、毒谷、块状毒饵、粒状毒饵、片状毒饵、浓毒饵、缓释块、静电喷雾剂、水包油乳剂、烟雾罐、烟雾烛、烟雾筒、烟雾棒、烟雾片、烟雾丸、发气剂、油膏、热雾剂、冷雾剂、气雾剂、固/液混合装剂、液/液混合装剂、固/固混合装剂、药漆、微粒剂、追踪粉剂、油悬剂、油分散性粉剂、浓胶剂、泼浇剂、种衣剂、涂抹剂、成膜油剂、超低容量液剂、蒸汽释放剂；Preferably, the dosage form processed by the acaricidal composition is selected from the group consisting of: seed treatment emulsion, water emulsion, microemulsion, suspoemulsion, capsule suspension, water-soluble granule, fine granule, soluble concentrate, poisonous valley, block Bait, granular bait, flake bait, concentrated bait, slow release block, electrostatic spray, oil-in-water emulsion, smoke can, smoke candle, smoke tube, smoke stick, smoke sheet, smoke pill, gas generator, ointment, Hot mist, cold spray, aerosol, solid/liquid mixed charge, liquid/liquid mixed charge, solid/solid mixed charge, lacquer, microparticle, trace powder, oil suspension, oil dispersible powder , thickener, pouring agent, seed coating agent, smear agent, film forming oil agent, ultra low volume liquid agent, steam release agent;

优选地，所述杀螨组合物防治的螨害选自：螨害选自叶螨科、细须螨科、呋线螨、瘿螨科、红叶螨属、瘿螨科的害螨，这些害螨是世界性农业害螨、林业害螨、园艺害螨和卫生害螨；Preferably, the cockroach damage controlled by the acaricidal composition is selected from the group consisting of: the mites are selected from the group consisting of the genus Aphididae, the genus The pests of the genus Polygonaceae, the genus Amaranthus, and the genus Polygonaceae are the world's agricultural pests, forest pests, horticultural pests and health hazards;

优选地，所述杀螨组合物用于防治的植物选自：稻谷、小麦、大麦、燕麦、玉米、高粱、甘薯、马铃薯、木薯、大豆、荷兰豆、蚕豆、豌豆、绿豆、小豆、棉花、蚕桑、花生、油菜、芝麻、向日葵、甜菜、甘蔗、咖啡、可可、人参、贝母、橡胶、椰子、油棕、剑麻、烟草、番茄、辣椒、萝卜、黄瓜、白菜、芹菜、榨菜、甜菜、油菜、葱、大蒜、西瓜、甜瓜、哈密瓜、木瓜、苹果、柑桔和桃树、茶、山野菜、竹笋、啤酒花、胡椒、香蕉、番木瓜、兰花、盆景。 Preferably, the plant for controlling the acaricidal composition is selected from the group consisting of: rice, wheat, barley, oats, corn, sorghum, sweet potato, potato, cassava, soybean, pea, broad bean, pea, mung bean, adzuki bean, cotton, sericulture , peanuts, rapeseed, sesame, sunflower, beet, sugar cane, coffee, cocoa, ginseng, fritillary, rubber, coconut, oil palm, sisal, tobacco, tomato, pepper, radish, cucumber, cabbage, celery, mustard, beet, Rape, onion, garlic, watermelon, melon, cantaloupe, papaya, apple, citrus and peach, tea, wild vegetables, bamboo shoots, hops, pepper, banana, papaya, orchid, bonsai.