WO2017092169A1 - Dispositif, système et procédé de surveillance dynamique de glycémie - Google Patents

Dispositif, système et procédé de surveillance dynamique de glycémie Download PDF

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Publication number
WO2017092169A1
WO2017092169A1 PCT/CN2016/071798 CN2016071798W WO2017092169A1 WO 2017092169 A1 WO2017092169 A1 WO 2017092169A1 CN 2016071798 W CN2016071798 W CN 2016071798W WO 2017092169 A1 WO2017092169 A1 WO 2017092169A1
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WO
WIPO (PCT)
Prior art keywords
blood glucose
blood
dynamic
user
monitoring device
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PCT/CN2016/071798
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English (en)
Chinese (zh)
Inventor
张贯京
陈兴明
葛新科
Original Assignee
深圳市易特科信息技术有限公司
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Publication of WO2017092169A1 publication Critical patent/WO2017092169A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1473—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase
    • A61B5/14865—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors

Definitions

  • the invention relates to the field of life health, and in particular to a dynamic blood glucose monitoring device, system and method for a diabetic patient.
  • Blood glucose testing to measure glucose levels in the blood should be performed daily for patients with fluctuating blood glucose levels. For the diagnosis of patients with severe diabetes or other specialist diseases, repeated blood glucose tests may be repeated within one day, which may result in low blood glucose detection accuracy.
  • blood glucose testing is often performed in hospitals or other medical research institutions, blood glucose monitoring currently uses multiple blood tests to detect blood glucose, while diabetic patients need 3-6 tests a day to meet demand, and the collected blood glucose data are mostly Local storage, unable to achieve blood glucose data docking with the Diabetes Medical Center, can not achieve the doctor's simultaneous monitoring of diabetes patients.
  • the current blood glucose monitoring system cannot continuously monitor the blood glucose data of diabetic patients 24 hours a day, for the doctor to remotely track the blood glucose level of diabetic patients in real time, which is used for daily blood glucose testing by doctors and diabetic patients. Very inconvenient with tracking.
  • the main object of the present invention is to provide a dynamic blood glucose monitoring device, system and method, which aim to solve the problem that the existing blood glucose detection accuracy is not high and the doctor cannot monitor the blood glucose data of the diabetic patient in real time.
  • the present invention provides a dynamic blood glucose monitoring device comprising a blood sampling probe, a biochemical reaction sensor, a microcontroller, a blood pressure sensor, and a wireless communication unit, wherein:
  • the blood collection probe is used for real-time dynamic collection of the user's blood and output to the biochemical reaction sensor, and the biochemical reaction sensor includes a blood glucose oxidase reagent and a circuit resistance;
  • the biochemical reaction sensor is configured to output a changing current signal by causing a blood glucose oxidation reaction of the blood glucose oxidase reagent and the blood drawn by the blood collection probe to cause a change in a resistance value of the circuit resistance;
  • the microcontroller is configured to calculate a blood glucose concentration value of the user according to a current signal output by the biochemical reaction sensor;
  • the blood pressure sensor is configured to detect a blood pressure value of the user, and send the blood pressure value of the user to the microcontroller;
  • the microcontroller is further configured to correct an error in the blood glucose concentration value measurement according to a blood pressure value of the user;
  • the wireless communication unit is configured to transmit the corrected blood glucose concentration value to a mobile communication terminal.
  • the dynamic blood glucose monitoring device further comprises a power switch connected to the microcontroller for turning the dynamic blood glucose monitoring device on or off.
  • the dynamic blood glucose monitoring device further includes a miniature battery connected to the microcontroller, the micro battery being a low-radiation, low-power rechargeable lithium battery or a button battery for The dynamic blood glucose monitoring device provides working power.
  • the microcontroller calculates a blood glucose concentration value corresponding to the current signal output by the biochemical reaction sensor by using a correlation function between the biochemical response sensor output current change and the blood glucose concentration.
  • the microcontroller corrects an error in the measurement of the blood glucose concentration value according to a blood pressure value of the user by using a relationship function between blood pressure and blood sugar of the human body.
  • the present invention also provides a dynamic blood glucose monitoring system including the dynamic blood glucose monitoring device, a mobile communication terminal, and a medical monitoring platform, the dynamic blood glucose monitoring device being connected to the mobile through a wireless network A communication terminal that is connected to the medical monitoring platform via a remote communication network.
  • the mobile communication terminal dynamically displays the corrected blood glucose concentration value on a display screen of the mobile communication terminal, and transmits the corrected blood glucose concentration value to the medical monitoring through the remote communication network
  • the doctor can remotely and dynamically track the user's blood glucose level in real time.
  • the present invention further provides a dynamic blood glucose monitoring method for use in a dynamic blood glucose monitoring device, the device comprising a blood collection probe, a biochemical reaction sensor, a microcontroller, a blood pressure sensor, and a wireless communication unit, the dynamic blood glucose monitoring Methods include:
  • the blood sampling probe dynamically collects the user's blood in real time and outputs it to the biochemical reaction sensor
  • the blood glucose oxidase reagent in the biochemical reaction sensor and the blood drawn by the blood sampling probe cause a blood glucose oxidation reaction to cause a change in a resistance value of a circuit resistance in the biochemical reaction sensor to output a changed current signal;
  • the microcontroller calculates a blood glucose concentration value of the user according to a current signal output by the biochemical reaction sensor;
  • the blood pressure sensor detects a blood pressure value of the user, and sends the blood pressure value of the user to the microcontroller;
  • the microcontroller corrects an error in the measurement of the blood glucose concentration value according to a blood pressure value of the user
  • the wireless communication unit transmits the corrected blood glucose concentration value to the mobile communication terminal.
  • the dynamic blood glucose monitoring device is connected to the mobile communication terminal through a wireless network, and the mobile communication terminal is connected to the medical monitoring platform through a remote communication network.
  • the dynamic blood glucose monitoring method further comprises the steps of:
  • the corrected blood glucose concentration value is transmitted to the medical monitoring platform through the remote communication network by the mobile communication terminal, so that the doctor can dynamically and dynamically track the user's blood glucose concentration level in real time.
  • the dynamic blood glucose monitoring device, system and method of the present invention are applied to dynamic blood glucose monitoring of diabetic patients, can improve the accuracy of blood glucose concentration monitoring and realize uninterrupted dynamics 24 hours a day. Monitoring the blood glucose data of diabetic patients for the doctor to remotely track the user's blood glucose concentration level in real time, which provides great convenience for both diabetic patients and doctors to monitor blood glucose data.
  • FIG. 1 is a system architecture diagram of a preferred embodiment of the dynamic blood glucose monitoring system of the present invention
  • Figure 2 is a diagram showing the internal structure of a preferred embodiment of the dynamic blood glucose monitoring device of the present invention
  • FIG. 3 is a flow chart of a preferred embodiment of the dynamic blood glucose monitoring method of the present invention.
  • the present invention provides a dynamic blood glucose monitoring system capable of improving the accuracy of blood glucose concentration monitoring and continuously monitoring blood glucose data of diabetic patients 24 hours a day for a doctor to remotely operate in real time. Tracking the user's blood glucose level provides great convenience for blood glucose data monitored by both diabetics and doctors.
  • FIG. 1 is a system architecture diagram of a preferred embodiment of the dynamic blood glucose monitoring system of the present invention.
  • the dynamic blood glucose monitoring system includes a dynamic blood glucose monitoring device 1, a mobile communication terminal 2, and a medical monitoring platform 3.
  • the dynamic blood glucose monitoring device 1 is connected to the mobile communication terminal 2 via a wireless network 4, which is connected to the medical monitoring platform 3 via a remote communication network 5.
  • the wireless network 4 includes, but is not limited to, a wireless transmission network such as Bluetooth, WiFi, etc.
  • the remote communication network 5 includes, but is not limited to, a wireless transmission network such as a GSM network, a GPRS network, or a CDMA.
  • the dynamic blood glucose monitoring device 1 is a wearable dynamic blood glucose monitoring device worn on a user (for example, a diabetic patient), and can be integrated on a wearable device such as a universal wristwatch or a wristband.
  • the mobile communication terminal 2 includes, but is not limited to, a wireless communication device such as a mobile phone, a personal digital assistant (PDA), a palmtop computer, or the like.
  • the medical monitoring platform 3 is a remote monitoring device or server or the like disposed at the diabetes medical monitoring center.
  • the user refers to a diabetic patient or other patient who needs to dynamically monitor blood glucose levels in real time.
  • the dynamic blood glucose monitoring device 1 is configured to dynamically collect the blood glucose concentration value of the user in real time 24 hours a day, and send the blood glucose concentration value of the user to the mobile communication terminal 2 through the wireless network 4 . Displayed on the screen to let users dynamically understand their blood glucose level.
  • the mobile communication terminal 2 transmits the blood glucose concentration value of the user to the medical monitoring platform 3 set in the diabetes medical monitoring center through the remote communication network 5, so that the doctor can remotely track the blood sugar concentration level of the user in real time.
  • Fig. 2 is an internal structural view of a preferred embodiment of the dynamic blood glucose monitoring device of the present invention.
  • the dynamic blood glucose monitoring device 1 includes, but is not limited to, a power switch 10, a blood collection probe 11, a biochemical reaction sensor 12, a microcontroller 13, a blood pressure sensor 14, and a wireless communication unit 15.
  • the power switch 10, the blood collection probe 11, the biochemical reaction sensor 12, the blood pressure sensor 14, and the wireless communication unit 15 are electrically connected to the microcontroller 13, respectively, and the blood collection probe 11 is further connected to the biochemical reaction sensor 12. .
  • the power switch 10 is configured to turn on or off the dynamic blood glucose monitoring device.
  • the blood collection probe 11 is configured to dynamically collect the user's blood in real time, and send the user's blood to the biochemical. Reaction sensor 12.
  • the blood collection probe 11 automatically penetrates the subcutaneous tissue of the user's wrist and draws blood from the wrist.
  • the blood collection probe 11 is a small probe with micropores, which does not cause a significant pain to the user when piercing the subcutaneous tissue of the user, thereby reducing pain when the user collects blood.
  • the blood of the user can also be sucked from the external blood storage tube by the blood collection probe 11 in real time, and the blood storage tube stores the blood to be detected by the user and dynamically updates the blood in real time.
  • the biochemical reaction sensor 12 includes a blood glucose oxidase reagent and a circuit resistance.
  • the biochemical reaction sensor 12 acquires the collected blood from the blood collection probe 11, the blood glucose oxidase reagent and the biochemical reaction sensor 12
  • the blood glucose oxidation reaction causes a change in the resistance value of the circuit resistance to output a varying current signal, and outputs the current signal to the microcontroller 13.
  • the microcontroller 13 is a microprocessor, a data processing chip, or an information processing unit having data processing functions.
  • the microcontroller 13 is configured to calculate a blood glucose concentration value of the user according to the current signal output by the biochemical reaction sensor 12.
  • the microcontroller 13 calculates a blood glucose concentration value corresponding to the current signal output by the biochemical reaction sensor 12 by using the biochemical response sensor 12 to output a relationship function between the current change and the blood glucose concentration.
  • the relationship between the current change and the blood glucose concentration is predefined and solidified within the chip of the microcontroller 13.
  • the blood pressure sensor 14 is a miniature blood pressure sensor chip for detecting the pulse pressure value of the human wrist artery, and is closely attached to the wrist artery of the human body to detect the blood pressure of the human body.
  • the blood pressure sensor 14 is configured to detect a blood pressure value of the user from the wrist artery of the user, and send the blood pressure value of the user to the microcontroller 13, the microcontroller 13
  • the error in the measurement of the blood glucose concentration value is corrected based on the blood pressure value of the user.
  • the microcontroller 13 uses the relationship function between the human blood pressure and the blood glucose to correct the error in the blood glucose concentration value measurement according to the blood pressure value of the user, so as to further improve the accuracy of detecting the blood glucose concentration.
  • the relationship between the blood pressure of the human body and blood sugar is predefined and solidified within the chip of the microcontroller 13.
  • the wireless communication unit 15 is a wireless communication interface supporting a wireless transmission network such as Bluetooth or WiFi, and is configured to send the blood glucose concentration value of the user to the mobile communication terminal 2 through the wireless network 4 for mobile communication.
  • the terminal 2 dynamically displays the blood glucose concentration value of the user on the display screen of the mobile communication terminal 2, so that the user dynamically knows his blood glucose concentration level in real time.
  • the mobile communication terminal 2 can also transmit the blood glucose concentration value of the user to the medical monitoring platform 3 through the remote communication network 5, so that the doctor can remotely track the blood glucose concentration level of the user in real time, thereby serving the user and It is convenient for both doctors to dynamically monitor blood sugar levels.
  • the dynamic blood glucose monitoring device 1 further includes a micro battery 16 connected to the microcontroller 13 for providing operating power to the dynamic blood glucose monitoring device 1.
  • the miniature battery 16 is a low-radiation, low-power rechargeable lithium battery or button battery that does not affect the health of the user.
  • the present invention also provides a dynamic blood glucose monitoring method, which can improve the accuracy of blood glucose concentration monitoring and realize continuous monitoring of blood glucose data of diabetic patients 24 hours a day for doctors in real time. Remotely tracking the user's blood glucose level provides great convenience for both diabetics and doctors to monitor blood glucose data.
  • FIG. 3 is a flow chart of a preferred embodiment of the dynamic blood glucose monitoring method of the dynamic blood glucose monitoring device of the present invention.
  • the dynamic blood glucose monitoring method is applied to the dynamic blood glucose monitoring device 1, the mobile communication terminal 2, and the medical monitoring platform 3, and the method includes the following steps S31 to S36.
  • step S31 the blood collection probe 11 dynamically collects the blood of the user in real time and outputs it to the biochemical reaction sensor 12.
  • the microcontroller 13 drives the blood of the automatic blood collection probe 11 on the dynamic blood glucose monitoring device 1 and outputs it to the biochemical reaction sensor 12.
  • the microcontroller 13 controls the blood collection probe 11 to automatically puncture the subcutaneous tissue of the user's wrist and draw blood from the wrist.
  • the blood of the user can also be sucked from the external blood storage tube by the blood collection probe 11 in real time, and the blood storage tube stores the blood to be detected by the user and dynamically updates the blood in real time.
  • Step S32 the blood glucose oxidase reagent in the biochemical reaction sensor 12 and the blood drawn by the blood sampling probe cause a blood glucose oxidation reaction to cause a change in the resistance value of the circuit resistance in the biochemical reaction sensor 12 to output a changed current signal, and The current signal is output to the microcontroller 13.
  • step S33 the microcontroller 13 calculates the blood glucose concentration value of the user based on the current signal output by the biochemical reaction sensor 12.
  • the microcontroller 13 calculates a blood glucose concentration value corresponding to the current signal output by the biochemical reaction sensor 12 by using the biochemical response sensor 12 to output a relationship function between the current change and the blood glucose concentration.
  • the relationship between the current change and the blood glucose concentration is predefined and solidified within the chip of the microcontroller 13.
  • Step S34 the blood pressure sensor 14 measures the blood pressure value of the user, and sends the blood pressure value of the user to the microcontroller 13, and the microcontroller 13 corrects the blood glucose concentration value measurement according to the blood pressure value of the user. Error.
  • the microcontroller 13 uses the relationship function between the human blood pressure and the blood glucose to correct the error in the blood glucose concentration value measurement according to the blood pressure value of the user, so as to further improve the accuracy of detecting the blood glucose concentration.
  • the relationship between the blood pressure of the human body and blood sugar is predefined and solidified within the chip of the microcontroller 13.
  • Step S35 the wireless communication unit 15 transmits the corrected blood glucose concentration value to the mobile communication terminal 2 via the wireless network 4, so that the mobile communication terminal 2 dynamically displays the corrected blood glucose concentration value on the mobile communication terminal 2 On the display screen, users can dynamically understand their blood glucose concentration levels in real time, thus providing users with the convenience of monitoring their own changes in blood glucose concentration.
  • Step S36 the mobile communication terminal 2 transmits the corrected blood glucose concentration value to the medical monitoring platform 3 through the remote communication network 5, so that the doctor can dynamically and remotely track the user's blood glucose concentration in real time.
  • the level provides convenience for the doctor to track and monitor changes in the user's blood glucose levels.

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Abstract

La présente invention concerne un dispositif, un système et un procédé de surveillance dynamique de glycémie, étant appliqués à la surveillance de la glycémie pour un patient diabétique. Le système de surveillance dynamique de glycémie comprend un dispositif de surveillance dynamique de glycémie (1), un terminal de communication mobile (2) et une plate-forme de surveillance médicale (3). Le dispositif de surveillance dynamique de glycémie (1) est connecté au terminal de communication mobile (2) au moyen d'un réseau sans fil (4), et le terminal de communication mobile (2) est connecté à la plate-forme de surveillance médicale (3) au moyen d'un réseau de communication distant (5). Le dispositif de surveillance dynamique de glycémie (1) détecte de façon dynamique, en temps réel, les valeurs de concentration de glycémie d'un utilisateur, et envoie les valeurs de concentration de glycémie de l'utilisateur au terminal de communication mobile (2), et les valeurs de concentration de glycémie de l'utilisateur sont affichées de façon dynamique sur un écran d'affichage du terminal de communication mobile (2). Le terminal de communication mobile (2) transmet, au moyen du réseau de communication distant (5), les valeurs de concentration de glycémie de l'utilisateur à la plate-forme de surveillance médicale (3), de sorte qu'un médecin puisse suivre de façon dynamique et à distance, en temps réel, le niveau de concentration de glycémie de l'utilisateur. Cette invention apporte une commodité à l'utilisateur et au médecin pour surveiller les données de glycémie du patient diabétique.
PCT/CN2016/071798 2015-12-05 2016-01-23 Dispositif, système et procédé de surveillance dynamique de glycémie WO2017092169A1 (fr)

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CN201510888836.4 2015-12-05
CN201510888836.4A CN105496422A (zh) 2015-12-05 2015-12-05 动态血糖监护装置、***及方法

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CN106770526A (zh) * 2017-01-11 2017-05-31 朱斌 一种血糖测试方法
CN107743256A (zh) * 2017-10-31 2018-02-27 广东九联科技股份有限公司 一种带血糖测试的机顶盒及其测试方法
CN109360665A (zh) * 2018-08-30 2019-02-19 中南大学 一种用于儿童青少年糖尿病管控的课堂综合管理***
CN109406791A (zh) * 2018-12-11 2019-03-01 中南大学湘雅三医院 血糖连续监测***
CN113812945B (zh) * 2021-07-29 2022-07-19 重庆市人民医院 一种跟踪型动态血糖检测仪

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CN101803912A (zh) * 2010-03-01 2010-08-18 北京康瑞华泰医药科技有限公司 可无线传送信息的医疗检测仪
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