WO2017081301A1 - Système pour améliorer la circulation sanguine - Google Patents

Système pour améliorer la circulation sanguine Download PDF

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Publication number
WO2017081301A1
WO2017081301A1 PCT/EP2016/077506 EP2016077506W WO2017081301A1 WO 2017081301 A1 WO2017081301 A1 WO 2017081301A1 EP 2016077506 W EP2016077506 W EP 2016077506W WO 2017081301 A1 WO2017081301 A1 WO 2017081301A1
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WO
WIPO (PCT)
Prior art keywords
thrombus
unit
bloodstream
detection unit
removal unit
Prior art date
Application number
PCT/EP2016/077506
Other languages
German (de)
English (en)
Inventor
David Blömer
Markus Blömer
Original Assignee
David Blömer
Markus Blömer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by David Blömer, Markus Blömer filed Critical David Blömer
Publication of WO2017081301A1 publication Critical patent/WO2017081301A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32—Surgical cutting instruments
    • A61B17/3205—Excision instruments
    • A61B17/3207—Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6867—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive specially adapted to be attached or implanted in a specific body part
    • A61B5/6876—Blood vessel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/06—Measuring blood flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
    • A61B8/0833—Detecting organic movements or changes, e.g. tumours, cysts, swellings involving detecting or locating foreign bodies or organic structures
    • A61B8/085—Detecting organic movements or changes, e.g. tumours, cysts, swellings involving detecting or locating foreign bodies or organic structures for locating body or organic structures, e.g. tumours, calculi, blood vessels, nodules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/52—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/5215—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data
    • A61B8/5223—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data for extracting a diagnostic or physiological parameter from medical diagnostic data
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/30—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/02007—Evaluating blood vessel condition, e.g. elasticity, compliance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/026—Measuring blood flow
    • A61B5/0261—Measuring blood flow using optical means, e.g. infrared light

Definitions

  • the invention relates to a system for improving blood flow.
  • the patent application US 2007/0213613 A1 discloses a device for detecting a thrombus, the device having a transducer which is attached to a region of a patient to be monitored and transmits and receives ultrasonic waves.
  • the apparatus further includes a transmitting and receiving unit which transmits drive pulses to the transducer and receives echo signals from the transducer.
  • a detector uses ultrasonic waves, processes output signals of the transmitting and receiving unit and detects a thrombus moving in a blood vessel.
  • the device further comprises a light source for generating examination light and a probe, which is attached to the monitored area of the patient and irradiates the patient with the examination light of the light source.
  • a light receiving unit receives the examination light emitted from the probe and passed through the patient, and outputs electrical signals in response to the intensity of the examination light received.
  • Another detector uses the examination light, wherein the output signals of the light receiving unit are processed and a thrombus, which moves through the blood vessel, is detected.
  • thrombi result from blood coagulation, whereby a thrombus at its point of origin can lead to clogging of the bloodstream.
  • a thrombus may detach from its site of origin and then be transported by the bloodstream to another site where the thrombus clogs the bloodstream. This migration of thrombi with subsequent blockage of the bloodstreams can lead to one or more organs being no longer adequately supplied with blood, which can cause heart attacks, in particular strokes or heart attacks.
  • blood-thinning medications can be taken.
  • the infarction risk can also be relatively high when taking these blood-thinning medications.
  • the object is achieved by a system for improving blood flow, the system comprising:
  • a thrombus detection unit for detecting a thrombus in a bloodstream of a living being
  • a thrombus removal unit for removing the thrombus
  • control unit for controlling the thrombus removal unit, wherein the control unit is adapted to control the thrombus removal unit such that when the thrombus detection unit has detected a thrombus. this is eliminated by means of the thrombus removal unit,
  • the thrombus detection unit and the thrombus removal unit are implantable so that in the blood flow direction, the thrombus detection unit is arranged in front of the thrombus removal unit.
  • the thrombus detection unit can detect a thrombus migrating in the bloodstream and report the detection of the migrating thrombus to the thrombus clearance unit, after which it eliminates the thrombus. This can reduce the likelihood that the migrating thrombus will disrupt the blood supply to an organ, such as the brain or heart, which can significantly reduce the risk of heart attack.
  • the control unit is preferably implantable.
  • the thrombus detection unit and / or the thrombus removal unit and / or the control unit are preferably integrated in one unit.
  • the thrombus removal unit and the control unit may be integrated in a first unit, and the thrombus detection unit may be implemented in a second, second unit separate from the first unit.
  • the thrombus detection unit and the thrombus removal unit are implantable so that in the blood flow direction, the thrombus detection unit is arranged in front of the thrombus removal unit.
  • the living entity is preferably a human. But it can also be an animal.
  • the thrombus detection unit can be arranged in a ring around the bloodstream. This allows implantation of the thrombus detection unit without having to intervene in the bloodstream. As a result, a more gentle for the body implantation is possible.
  • the thrombus detection unit preferably has a radiation source for emitting radiation into the bloodstream and a radiation detector for detecting the radiation after it has passed through the bloodstream, wherein the thrombus detection unit is adapted to detect a thrombus in dependence on the detected radiation.
  • the radiation is for example optical radiation, ultrasonic radiation, et cetera.
  • the radiation source is, for example, a light emitting diode (LED) and the radiation detector is for example a photodiode. This allows a very accurate detection of a thrombus based on the thrombus altered absorption of radiation within the bloodstream.
  • the thrombus removal unit may be adapted to filter the thrombus from the bloodstream to eliminate it.
  • the thrombus removal unit may also be adapted to destroy the thrombus to eliminate it.
  • the thrombus remedy unit may be adapted to "chop" the thrombus. The filtering and disrupting may also be combined so that the thrombus remedy unit is adapted to first filter the thrombus from the bloodstream and then destroy the thrombus filtered out effective elimination of the thrombus.
  • the thrombus removal unit preferably has an alternate bloodstream and is adapted to deliver a thrombus to the alternate bloodstream.
  • the thrombus removal unit may be adapted to clear the thrombus in the alternate bloodstream. For example, a filtering of the thrombus from the blood and / or a Destruction of the thrombus can be performed in the alternate bloodstream. This too leads to a very effective removal of the thrombus from the bloodstream.
  • the control unit may be adapted to control the thrombus clearance unit to activate the eradication of the thrombus after a predetermined time has elapsed after detection of the thrombus by the thrombus detection unit.
  • the predetermined time may be determined in advance based on the distance between the thrombus detection unit and the thrombus removal unit and the blood flow velocity so that the process for clearing the thrombus is surely activated before the detected thrombus can reach the thrombus clearance unit.
  • the control unit may be adapted to start a destructive process such as a chopping process or a diverting process for diverting the thrombus into the alternate bloodstream only after a predetermined time has elapsed after detection of the thrombus.
  • the mechanism for clearing the thrombus is therefore activated only when it is really needed, which can reduce the system's power consumption.
  • control unit is adapted to receive information from an external entity external to the animal and to control the thrombus removal entity in response to the received information.
  • the external unit is for example a computer, wherein the information can be transmitted by means of a wireless data connection.
  • the type of thrombus removal can be determined depending on the external unit.
  • the external unit may be connected to a cloud infrastructure in which control information describing the control of the thrombus eradication unit may be generated.
  • the external unit may also include a neural network to automatically determine control information in dependence on other health-related information such as blood values, patient data such as age, sex, medical history, et cetera.
  • the control unit may be adapted to control another unit to be controlled. It is preferred that the further unit to be controlled comprises one or more units selected from a group consisting of: cardiac pacemaker, brain pacemaker and drug delivery unit.
  • the control unit is adapted to receive information from an external entity external to the animal and to control the entity to be controlled in response to the received information.
  • the external unit is for example a computer, wherein the information can be transmitted by means of a wireless data connection.
  • the external entity may be using a cloud infrastructure be connected, in the control information can be generated, which describe the control of the other unit to be controlled.
  • the external unit may also include a neural network to provide control information in dependence on other health-related information such as blood values, patient data such as age, sex.
  • the system may be adapted to determine the degree of thrombus removal, for example optically and / or by means of ultrasound.
  • a further thrombus detection unit may be arranged in the flow direction, which may detect an incompletely eliminated thrombus.
  • the size, in particular the length in the direction of flow, can be determined before and after the elimination so as to determine the degree of elimination, for example by forming a difference or a ratio.
  • the system may also be adapted to send detection data describing the detection of the thrombus and / or elimination data describing the elimination of the thrombus to an external unit and / or to store it in the system.
  • the external unit can be read out so that the detection data and / or the removal data can be output and optionally further processed.
  • the detection data describe, for example, that a thrombus has been detected and when the thrombus has been detected.
  • the size of the thrombus in particular the length of the thrombus in the flow direction, may also be part of the detection data.
  • the elimination data may describe whether and, if so, when, a thrombus has been eliminated.
  • the degree of elimination can also be part of the elimination data.
  • the thrombus detection unit may be adapted to detect a further property of the blood in addition to the thrombus detection. This can be done, for example, by means of ultrasound or optically.
  • the thrombus detection unit may be adapted to generate an optical spectrum of the blood, in particular an absorption spectrum, and to determine the further property of the blood on the basis of the spectrum.
  • the other properties of the blood can be, for example, blood lipid levels, blood sugar levels, et cetera. These other properties of the blood can be used to control the thrombus removal unit and / or the other unit to be controlled, such as a cardiac pacemaker.
  • a set of rules can be used which defines the control depending on input data such as the properties of the blood, the degree of thrombus clearance, the detection of a thrombus, and so on.
  • This set of rules can be defined by a neural network. It should be understood that the term "A and / or B" includes: a) A without B, b) B without A and c) A and B.
  • the invention also relates to a method for improving blood flow, the method comprising:
  • Eliminating the thrombus by a thrombus removal unit wherein a control unit controls the thrombus removal unit such that when the thrombus detection unit has detected a thrombus, it is eliminated by the thrombus removal unit, wherein the thrombus detection unit and the thrombus removal unit are implanted so that in the blood flow direction the thrombus detection unit is located in front of the thrombus removal unit is arranged.
  • Fig. 1 shows schematically and exemplarily a person with an embodiment of a
  • Fig. 2 shows schematically and by way of example details of the embodiment of the system for improving the blood flow
  • Fig. 3 shows schematically and exemplarily a thrombus detection unit of the in the
  • Fig. 1 illustrated system shows
  • FIG. 4 shows a flow chart illustrating an embodiment of a method for
  • the system 1 shows schematically and by way of example a person 30 with an embodiment of a system 1 for improving blood flow. Details of the system 1 are illustrated in FIG.
  • the system 1 comprises a thrombus detection unit 2 for detecting a thrombus in a blood stream 3 and a thrombus removal unit 4 for removing the detected thrombus.
  • the bloodstream 3 is formed by a blood vessel, which may be an artery or a vein.
  • the system 1 further comprises a control unit 5 for controlling the thrombus removal unit 4, wherein the control unit 5 is adapted to control the thrombus removal unit 4 such that when the thrombus detection unit 2 detects a thrombus, it is eliminated by the thrombus removal unit 4.
  • the thrombus detection unit 2, the thrombus removal unit 4 and the control unit 5 are implanted so that the thrombus detection unit 2 is arranged in the blood flow direction 6 in front of the thrombus removal unit 4.
  • the thrombus removal unit 4 and the control unit 5 are integrated in one unit, whereas the thrombus detection unit 2 forms a separate unit, which is arranged at a distance from the integrated thrombus detection and control unit.
  • all the units that is to say the thrombus detection unit, the thrombus removal unit and the control unit, can also be integrated in one unit.
  • the thrombus detection unit, the thrombus removal unit and the control unit can each also form separate units.
  • the thrombus detection unit 2 is arranged in a ring around the blood stream 3, as illustrated schematically and by way of example in FIG. 3.
  • the thrombus detection unit 2 may initially consist of at least two separate parts, which are placed separately around the blood stream 3, where they are then connected to one another in order to enclose the bloodstream 3.
  • these at least two parts of the thrombus detection unit 2 can have plug-in connections in order to connect them to one another after arranging around the bloodstream 3 by means of a plug connection.
  • Other types of connection are possible, such as, for example, a magnetic connection, which can take place by means of corresponding magnets, which can be arranged at the ends of the at least two parts of the thrombus detection unit 2.
  • a dashed dividing line 18 between two connected parts of the thrombus detection unit 2 is indicated by way of example in FIG. 3.
  • the thrombus detection unit 2 comprises a radiation source 7 for emitting radiation into the bloodstream 3 and a radiation detector 8 for detecting the radiation after it has penetrated the bloodstream 3.
  • the radiation source 7 and the radiation detector 8 are each arranged in a semicircle around the blood stream 3.
  • the radiation source 7 may comprise one or more semi-circularly arranged LEDs
  • the radiation detector 8 may comprise one or more semicircularly arranged photodiodes.
  • the radiation source and the radiation detector may also be configured to irradiate the bloodstream by means of another type of radiation.
  • the radiation source and the radiation detector is adapted to emit and detect ultrasonic radiation.
  • the thrombus detection unit 2 also comprises a control unit, which control unit 9 is adapted to control the radiation source 7 and the radiation detector 8, to receive detection signals, which depend on the detected radiation, from the radiation detector 8 and to determine on the basis of these received detection signals a thrombus is located in the blood stream 3.
  • control unit 9 may be adapted to determine that a thrombus is in the blood stream 3 if the received detection signal indicates that the detected radiation is lower than a predetermined threshold, assuming that the reduced radiation is caused by a thrombus which is located between the radiation source 7 and the radiation detector 8.
  • the thrombus detection unit 2 furthermore comprises a communication unit 19 for communicating with the control unit 5.
  • This communication can be wireless or wired, in the latter case the thrombus removal unit 2 and the control unit 5 being connected by means of a wire connection. If the control unit 9 of the thrombus detection unit 2 has determined that a thrombus is present in the bloodstream 3, this is reported to the control unit 5 by means of the communication unit 19, whereafter the control unit 5 initiates a removal of the thrombus.
  • the thrombus detection unit 2 further comprises a power supply 10 for supplying the different components of the thrombus removal unit 2 with electrical energy.
  • the electrical energy provided is distributed by means of the control unit 9 to the various components of the thrombus removal unit 2.
  • the power source 10 is preferably a battery.
  • the thrombus removal unit 4 comprises an alternative bloodstream 1 1, which is formed by a housing 17.
  • the alternate bloodstream 1 1 includes an entrance area 20 through which the blood from the blood stream 3 can flow into the alternate bloodstream 1 1, and an exit area 21 through which the blood from the alternate bloodstream 1 1 flows back into the bloodstream 3 can.
  • the thrombus removal unit 4 is adapted to direct a detected thrombus into the evasive bloodstream 1 1 and eliminate it there, so that in the exit area 21 blood flows back into the bloodstream 3, in which no thrombus is present.
  • the removal of the thrombus in the evasive bloodstream is effected by means of a filter unit 15.
  • the filter unit 15 is preferably exchangeable and may also be referred to as a filter cartridge. Unit 15 may have openings that allow blood to pass through, but do not allow the thrombus to pass.
  • the active flow regulator 12 comprises a closure element 14 which is actuable by means of a motor 13, which could also be regarded as a micromotor.
  • the motor 13 and the closure element 14 are adapted such that the closure element 14 is pivotable between a closed position, which is illustrated in solid lines in FIG. 2, and an open position, which is illustrated by dashed lines in FIG. 2.
  • the closed position the alternate bloodstream 1 1 is closed by the closure element 14, so that no blood can flow into the alternate bloodstream 1 1.
  • the input area 20 of the alternate bloodstream 1 1 is opened, so that blood from the blood stream 3 in the alternate bloodstream 1 1 can flow.
  • control unit 5 is preferably connected to the motor 13 by means of a wire, so that the control unit 5 can control the active flow controller 12. In another embodiment, this connection can also be wireless.
  • the active flow regulator 12 is in the closed position, so that the blood can flow past the bloodstream 3 through the bloodstream 1 1. If, however, the thrombus detection unit 2 detects a thrombus, this detection is reported by the thrombus detection unit 2 to the control unit 5, after which the control unit 5 controls the active flow regulator 12 so that it changes from the closed position to the open position and the blood and thus the thrombus in the entrance area 20 of the alternate bloodstream 1 1 is directed into this and flows through the filter unit 15, in which the thrombus is retained.
  • the control unit 5 can be designed such that it controls the active flow controller 12 so that it is changed immediately from the closed position to the open position after the control unit 5 has been informed of the detection of the thrombus.
  • control unit 5 can also be adapted so that the closure position of the active flow controller 12 to the open position of the active flow controller 12 is changed only after, after the detection of the thrombus by the thrombus detection unit 2, a predetermined time has expired.
  • This predetermined time has preferably been determined taking into account the distance between the thrombus detection unit 2 and the thrombus removal unit 4 and the maximum expected blood flow rate. In particular, this predetermined time is determined so that the active flow regulator 12 is safe in the Opening position is when a thrombus detected by the thrombus detection unit 2 has reached the thrombus removal unit 4.
  • a passive flow regulator 16 which can also be understood as a passive valve and the blood can flow only from the alternate bloodstream 1 1 in the blood stream 3.
  • the thrombus removal unit 4 further comprises a communication unit 22 for communicating with the thrombus detection unit 2, and preferably also for communicating with an external communication unit external to the patient.
  • the thrombus removal unit 4 comprises a current source 23, in particular a battery.
  • the current source 23 is adapted to supply the individual components, in particular the control unit 5 and the motor 13, with electrical energy.
  • the communication unit 22 and the power source 23 are integrated in the control unit 5. In other embodiments, these units may also be arranged separately from the control unit 5.
  • the entire system may have only one power source, which power source then supplies both the thrombus detection unit 2 and the thrombus removal unit 4 with electrical energy.
  • step 101 the thrombus detection unit 2 detects a thrombus in the blood stream 3 and notifies the control unit 5.
  • step 102 the control unit 5 controls the thrombus removal unit 4 such that the thrombus removal unit 4 eliminates the detected thrombus.
  • the thrombus removal unit 4 is preferably located closer to the heart or brain in the flow direction of the blood than the thrombus detection unit.
  • the control unit 5 is preferably adapted to control the active flow regulator 12 such that after a detected thrombus has been diverted into the alternate blood stream 11. the active flow regulator 12 is again in the closed position, so that the blood can again flow past the alternate blood stream 1 1 through the actual bloodstream 3.
  • the control unit 5 may be adapted to control the active flow regulator 12 so that the active flow regulator 12 is again in the closed position after a predetermined time has elapsed after the detection of the thrombus by the thrombus detection unit 2.
  • This predetermined time depends preferably on the distance between the thrombus detection unit 2 and the thrombus removal unit 4 and the minimum expected blood flow rate.
  • the predetermined time is preferably selected in consideration of these parameters so that it can be assumed that the thrombus is safely in the alternate bloodstream 1 1, when the active flow regulator 12 is moved again from the open position to the closed position.
  • a sensor for detecting the thrombus in the alternate bloodstream 11 may also be present. Similar to the thrombus detection unit 2, this sensor can have a radiation source and a radiation detector, it being possible to determine, depending on the detected radiation intensity, whether the thrombus detected by the thrombus detection unit 2 is now located in the alternate bloodstream 11.
  • the detected radiation intensity in the alternative blood stream 1 1 drops by a predetermined percentage after detection of the thrombus by the thrombus detection unit 2 and / or falls below a predetermined intensity threshold value, it can be determined that the thrombus has been diverted into the alternate bloodstream 11 is.
  • the thrombus removal unit 4 may also have a sensor to determine whether the filter unit 15 is filled, for example because of already filtered out thrombi, that it must be emptied or replaced.
  • a combination of a radiation source and a radiation detector can be used. The radiation source and the radiation detector can be arranged so that a filter unit 15 to be emptied or exchanged becomes noticeable by a decrease in the detected radiation intensity.
  • the control unit 5 may be adapted to receive information from an external unit 31, which is, for example, an external computer located outside of the person 30, and the thrombus removal unit 4 and / or another unit 32 to be controlled in response to the received To control information.
  • an external unit 31 is, for example, an external computer located outside of the person 30, and the thrombus removal unit 4 and / or another unit 32 to be controlled in response to the received To control information.
  • a wired or wireless data connection between the control unit 5 and the further unit 32 to be controlled is used.
  • the unit 32 to be controlled is a pacemaker in this embodiment. In another embodiment, however, the unit 32 to be controlled may be another unit that may affect the health of the subject 30, such as a brain pacemaker or drug delivery unit.
  • the control unit 5 may also control a plurality of units to be controlled, such as a pacemaker, a brain pacemaker, and a medication delivery unit.
  • the external unit 31 may be connected to a cloud infrastructure in which control information describing the control of the thrombus removal unit 4 may be generated.
  • the external unit may also include a neural network or other set of rules to automatically determine control information in dependence on other health-related information such as blood levels, patient data such as age, sex, medical history, et cetera.
  • the control unit 5 can also be adapted to store information provided by the thrombus detection unit 2 and / or information from the further unit 32 to be controlled in order to make it available to the external unit 31 or another external unit for analysis purposes .
  • the thrombus detection unit can be adapted to detect a further property of the blood in addition to thrombus detection. For this purpose, for example, by means of the radiation source 7 and the radiation detector 8, an absorption spectrum of the blood can be determined, which can use the thrombus detection unit for detecting the further property of the blood.
  • information about this further property of the blood can be stored by the control unit and / or sent to the external unit 31.
  • the other properties of the blood can be, for example, blood lipid levels, blood sugar levels, et cetera.
  • These further properties of the blood can be used to control the thrombus removal unit 4 and / or the further unit 32 to be controlled.
  • a set of rules can be used which defines the control depending on input data such as the properties of the blood, the degree of thrombus clearance, the detection of a thrombus, and so on. This set of rules can be defined by a neural network.
  • the thrombus repair unit is adapted to filter out the thrombus
  • the thrombus removal unit may be adapted to remove the thrombus in a different manner.
  • the thrombus removal unit can be adapted to destroy the thrombus.
  • it can have a chopping unit, which is preferably driven by a motor.
  • the control of the engine for the chaff can be done via the control unit 5.
  • the shredder can, for example, have small, oppositely rotating knife blades, which reduce the thrombus so much that it no longer represents a risk of infarction.
  • the thrombus removal unit has an alternate bloodstream
  • there may be no alternate bloodstream in which case the thrombus removal unit is preferably implanted directly into the bloodstream.
  • the thrombus removal unit is preferably adapted to destroy the thrombus, for example by means of the chopping unit mentioned above.
  • the thrombus detection unit 2 is arranged in a ring around the blood stream 3
  • the thrombus detection unit may also be arranged differently.
  • this unit may be implanted in the blood stream 3.
  • the thrombus removal unit 4 may also include a velocity sensor for measuring the velocity of blood flow.
  • the control unit 5 can calculate a time required for the detected thrombus to flow from the thrombus detection unit 2 to the thrombus removal unit 4. This time may be used to ensure that the active flow regulator 12 allows the thrombus to enter the escape bloodstream 1 1 when it has reached the thrombus removal unit 4. In addition, the control unit 5 can use this information to calculate when the thrombus has reliably reached the escape bloodstream 1 1, so that the control unit 5 can specify a corresponding time.
  • This time can then be used to control the active flow regulator 12 so that the evacuation blood stream 1 1 is closed again and the main blood lane 3 is released again when the thrombus is in the escape blood lane 1 1.
  • these times may also be predetermined, for example, by a surgeon implanting the system.
  • closure element of the active flow regulator is actuated by means of a motor
  • the closure element can also be actuated in another way.
  • the Closure element for example, electromechanical, electric, pneumatic, et cetera be actuated.
  • the active flow regulator 12 comprises a closure element 14 which is actuable by means of a motor 13, which could also be regarded as a micromotor.
  • the motor 13 and the closure element 14 are adapted so that the closure element 14 is pivotable between a closure position, which is illustrated in solid lines in FIG. 2, and an open position, which is illustrated by dashed lines in FIG. 2.
  • All components that come in contact with the patient's body are preferably made of biocompatible material.
  • the filter unit 15 is preferably a filter cartridge, wherein the housing 17 of the thrombus removal unit 4 preferably has a closable opening, which allows a surgeon to remove the filter cartridge so that it can be emptied and cleaned or replaced. During the removal of the filter cartridge, the active flow regulator 12 is in the closed position, in which no blood flows into the alternate blood stream 1 1.
  • Fig. 1 the system 1 is shown at a particular location on the body of the person 30, the system 1 may also be located at a different location on the body.
  • the words “comprise” * and “include” do not exclude other elements or steps, and the indefinite article “a” does not exclude a plurality.
  • a single unit or device can perform the functions of several elements listed in the claims.
  • the fact that individual functions and elements are listed in different dependent claims does not mean that a combination of these functions or elements could not be used to advantage.
  • control of the system for improving the blood flow according to the method for improving the blood flow may be implemented as program code of a computer program and / or as corresponding hardware.
  • a computer program may be stored and / or distributed on a suitable medium, such as an optical storage medium or a solid state storage medium, distributed along with or as part of other hardware.
  • the computer program can also be distributed in other forms, for example via the Internet or other telecommunication systems.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Surgery (AREA)
  • Medical Informatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Primary Health Care (AREA)
  • Data Mining & Analysis (AREA)
  • Physiology (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Epidemiology (AREA)
  • Databases & Information Systems (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)

Abstract

L'invention concerne un système (1) pour améliorer la circulation sanguine. Le système comprend une unité de détection de thrombus (2) pour détecter un thrombus dans une voie circulatoire (3), une unité d'élimination de thrombus (4) pour éliminer le thrombus, et une unité de commande (5) pour commander l'unité d'élimination de thrombus (4). L'unité de commande (5) commande l'unité d'élimination de thrombus (4) de sorte que, lorsque l'unité de détection de thrombus (2) a détecté un thrombus, celui-ci est éliminé au moyen de l'unité d'élimination de thrombus (4). L'unité de détection de thrombus (2) et l'unité d'élimination de thrombus (4) peuvent être implantées de sorte que dans la direction de circulation sanguine l'unité de détection de thrombus (2) se trouve en amont de l'unité d'élimination de thrombus (4).
PCT/EP2016/077506 2015-11-13 2016-11-11 Système pour améliorer la circulation sanguine WO2017081301A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102015222496.1 2015-11-13
DE102015222496.1A DE102015222496B3 (de) 2015-11-13 2015-11-13 System und Verfahren zur Verbesserung des Blutflusses

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WO2017081301A1 true WO2017081301A1 (fr) 2017-05-18

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DE (1) DE102015222496B3 (fr)
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Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5053008A (en) * 1990-11-21 1991-10-01 Sandeep Bajaj Intracardiac catheter
US20020165575A1 (en) * 2001-05-07 2002-11-07 Saleh Fathy M.A. Vascular filtration device
US20060178695A1 (en) * 2005-02-04 2006-08-10 Decant Leonard J Jr Vascular filter with sensing capability
US20070156211A1 (en) * 2004-04-19 2007-07-05 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Lumen-traveling device
US20070213613A1 (en) 2003-11-14 2007-09-13 Kazunari Ishida Thrombus Detecting Apparatus, Thrombus Treating Apparatus And Methods Therefor
US20140135815A1 (en) * 2012-11-09 2014-05-15 Elwha Llc Embolism Deflector
WO2015130184A1 (fr) * 2014-02-28 2015-09-03 Velja Stefan Endoprothèse permettant de retenir et de désagréger les caillots

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5361300A (en) * 1990-08-06 2000-10-26 Possis Medical, Inc. Thrombectomy method and device

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5053008A (en) * 1990-11-21 1991-10-01 Sandeep Bajaj Intracardiac catheter
US20020165575A1 (en) * 2001-05-07 2002-11-07 Saleh Fathy M.A. Vascular filtration device
US20070213613A1 (en) 2003-11-14 2007-09-13 Kazunari Ishida Thrombus Detecting Apparatus, Thrombus Treating Apparatus And Methods Therefor
US20070156211A1 (en) * 2004-04-19 2007-07-05 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Lumen-traveling device
US20060178695A1 (en) * 2005-02-04 2006-08-10 Decant Leonard J Jr Vascular filter with sensing capability
US20140135815A1 (en) * 2012-11-09 2014-05-15 Elwha Llc Embolism Deflector
WO2015130184A1 (fr) * 2014-02-28 2015-09-03 Velja Stefan Endoprothèse permettant de retenir et de désagréger les caillots

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