WO2017010953A1 - Surgical glue application gun - Google Patents

Surgical glue application gun Download PDF

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Publication number
WO2017010953A1
WO2017010953A1 PCT/TR2015/050037 TR2015050037W WO2017010953A1 WO 2017010953 A1 WO2017010953 A1 WO 2017010953A1 TR 2015050037 W TR2015050037 W TR 2015050037W WO 2017010953 A1 WO2017010953 A1 WO 2017010953A1
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WO
WIPO (PCT)
Prior art keywords
catheter
glue application
application gun
surgical glue
pulled
Prior art date
Application number
PCT/TR2015/050037
Other languages
French (fr)
Inventor
Rasit DINC
Original Assignee
Dinc Rasit
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dinc Rasit filed Critical Dinc Rasit
Priority to PCT/TR2015/050037 priority Critical patent/WO2017010953A1/en
Publication of WO2017010953A1 publication Critical patent/WO2017010953A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00491—Surgical glue applicators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00008—Vein tendon strippers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12181—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
    • A61B17/12186—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices liquid materials adapted to be injected

Definitions

  • the present invention is related to a medical device and a medical process.
  • I t is particularly related to a procedure and vehicle that is used in preventing varicose veins, preventing the progress of varicose veins, to close aneurysms, to block arteries, to provide a method for said treatments and to treat the related vein malformation.
  • the catheter that is to be used during application does not go into reaction with cyanoacrylate, that the application is not disrupted, that the catheter is not blocked and that the catheter dos not stick to the vein lumen.
  • the most efficient tool to use is the PTFE catheter.
  • PTFE generally is used in order to cover hydrophilic surfaces.
  • the most important characteristic of PTFE is that it does not react with chemicals and it is not affected by high temperatures. Cyanoacrylate transferred into the vein goes into exothermic reaction with the vein and a certain amount of heat is manifested and polymerization starts. During this time, it is a critical factor that while the vein lumen reciprocally sticks to each other the remaining catheter between does not adhere. For this reason the PTFE catheter whose characteristics we have defined need to be produced from pure FTFE raw material.
  • Methyl and ethyl groups show fast effects, and when they become rigid they are highly resistant but they are brittle and less elastic. They are preferred for fast results in surgical applications, and for their resistance when used in hard tissue such as bones.
  • Cyanoacrylates that comprise the butyl and octyl groups that form the subject of the invention show slower effects however when they become hard they still show elasticity features. At the same time they have inflammation effects on the endothelium . Especially in applications related to veins results that make them more preferable are obtained.
  • Figure 1 Example of glue application by following catheter with pressure apply
  • FIG. 2 Gun with Adaptor : Right side view Figure 3: Gun with Adaptor : Left side view Figure 4: Gun without adapter Figure 5: Adaptor : Side view Figure 6: Adaptor : Front view
  • the glue subject to the invention is used to prevent the formation of varicose veins/ to stop it from progressing, to treat varicose veins and to seal vena saphena magna.
  • Butyl based cyanoacrylic (N-Butyl-2-Cyanoacrylate) groups show more elasticity characteristics and as a result they are preferred in such applications.
  • Dimethyl sulfoxide (DMSO) is used as solvent for the cyanoacrylates to adjust the viscosity. DMSO is preferred because of its biocompatibility.
  • Octyl-2-cyanoacrylate comprising and octyl group is used as it is elastic such that it fills the aneurysm (By taking Table 2 as reference) when treating aneurysms with glues that can occur in cerebral veins.
  • cyanoacrylate is also used in the following applications:
  • I n order to stop hemorrhaging and to repair the lesions or to stick parenchyma tissue in hemorrhagic lesions of the liver, kidneys, pancreas and the spleen
  • I n order to seal and strengthen vascular sutures during lung transplantations.
  • I n order to treat seromas occurring after lymph node, and lateral neck and collarbone lymphorrhagia
  • Ethyl-2-Cyanoacrylate is preferred due to fast results in such applications.
  • Methyl cyanoacrylate is preferred as it is resistant and shows fast results.
  • Octyl- 2- Cyanoacrylate is preferred due to elasticity.
  • Octyl-2-Cyanoacrylate is preferred due to elasticity.
  • I n order to endoscopically treat the esophagus, esophagotrachial, gastric, gastro intestinal, duodenal and pancreatic fistulas
  • I n order to endoscopically treat gastric, duodenal and peptic ulcers
  • N-Butyl-2-Cyanoacrylate group is preferred due to its fast effects and elasticity.
  • N-Butyl-2-Cyanoacrylate is preferred as it has fast effects and shows elasticity in arterial and venous embolization.
  • the system features are based on the same principle. According to application the delivery catheter and the introducer sheath lengths and diameters change although the material they are formed of does not change. The selection of materials to be used during procedures is important as it should not react to the cyanoacrylic agent. At the same time these agents also need to be complaint for sterilization.
  • I ntroducer Sheath is not important if the introducer sheath is reactive to the cyanoacrylic agent or not as it does not have contact with said agent. However it is important that it is compliant with blood and the fact that it can be moved forward as it will be used inside the vein lumen.
  • Polyethylene raw material has been used to achieve this.
  • the most suitable density in terms of rigidity has been found.
  • Connector parts have been attached to the ends of the produced sheaths so that they can be attached suitably to the other system parts. Finally in order to provide practical usage, each cm on the sheath has been marked.
  • Polymer container I s a system that shall store the cyanoacrylic agent. I t is important that it does not show reaction to the cyanoacrylic agent. At the same time it should allow EO sterilization and should protect the cyanoacrylic polymer from reaction. For this reason container produced from HDPE have been preferred. LDPE and PU and PA materials have been tried but the results were not healthy.
  • Purpose of this new model is delivering agent inside of the vein lumen with fixed amount of dosage while pulling back the delivery catheter inside of the vessel lumen simultaneously.
  • a PTFE (polytetrafluoroethylene) delivery catheter with application gun that will deliver decided dose of cyanoacrylate according to the vessel diameter to the vessel lumen and specialty of system is the continuous application of cyanoacrylate while pulling the trigger and pulling back the delivery catheter continuously and simultaneously.
  • Adaptor is the part that connects syringe to the gun.
  • I t is adaptable to the all universal injectors.
  • I t has special spin-lock mechanism.
  • the other application of the device with the glue injection and catheter pullback mechanism is continuous pressure applied over the vein by hand or ultrasound probe over the vessel following catheter pullback cycle.
  • This technique provides lower complication rates and higher vessel closure rates while giving minimum foreign material injection inside of the body. Additionally patient comfort and life score is increasing.
  • Another advantage of the invention is closure of the vessel is looks like a string. I n this kind of other closure techniques, vessel lumen is thrombosed and looks like a circle filled inside under the ultrasound. This thrombus inside of the vein starts a thrombosis mechanism and closes the vein in the long term. With this invention vessel closure provides instantly and thrombosis mechanism is cancelled and / or decreased to minimum. Thus vessel closure is gained by endothelium damage without thrombosis function instantly.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Reproductive Health (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Materials For Medical Uses (AREA)

Abstract

This invention is about a medical device and application. Especially about method, device and procedure that prevents formation of varicose vein, stops progressing of varicose vein, treats varicose veins, closes aneurysms, blocks arteries.

Description

SURGI CAL GLUE APPLI CATI ON GUN TECHNI CAL FI ELD
The present invention is related to a medical device and a medical process. I t is particularly related to a procedure and vehicle that is used in preventing varicose veins, preventing the progress of varicose veins, to close aneurysms, to block arteries, to provide a method for said treatments and to treat the related vein malformation.
PRI OR ART
The adhesion speed, its endurance, elasticity, rigidity and its absorbability by the body, and besides this, the mm diameter to which it is applicable to, and dosage calculation by distinguishing arteries or veins have not been carried in relation to cyanoacrylate glues used in prior studies. I n the studies we have carried out, in Table 1 and Table 2, the required dosage amounts have been determined for application by taking into account the separation of arteries and veins and by taking millimetric diameters into account. The reason for this is that the vein structure differs from patient to patient. For example, a patient with varicose veins could have a vein diameter of 6mm and another could have a vein diameter of 9mm . This is proof that patients cannot be given a fixed dose and that different dose applications must be carried out according to the specific vein diameters of said patients. The diameters proximal or distal to the vein can differ even in the same patient. The application must be different if the application is to be performed on a vein or an artery.
Besides these, it is crucial that the catheter that is to be used during application does not go into reaction with cyanoacrylate, that the application is not disrupted, that the catheter is not blocked and that the catheter dos not stick to the vein lumen. For this reason, during the delivery stage of cyanoacrylates, the most efficient tool to use is the PTFE catheter. PTFE generally is used in order to cover hydrophilic surfaces. Moreover the most important characteristic of PTFE is that it does not react with chemicals and it is not affected by high temperatures. Cyanoacrylate transferred into the vein goes into exothermic reaction with the vein and a certain amount of heat is manifested and polymerization starts. During this time, it is a critical factor that while the vein lumen reciprocally sticks to each other the remaining catheter between does not adhere. For this reason the PTFE catheter whose characteristics we have defined need to be produced from pure FTFE raw material.
BRI EF DESCRI PTI ON OF THE I NVENTI ON Surgical glues are presently known in the industry and are medically applied cyanoacrylic based glues and said glues are transferred to the area to be treated by means of different methods.
Methyl and ethyl groups show fast effects, and when they become rigid they are highly resistant but they are brittle and less elastic. They are preferred for fast results in surgical applications, and for their resistance when used in hard tissue such as bones.
Cyanoacrylates that comprise the butyl and octyl groups that form the subject of the invention show slower effects however when they become hard they still show elasticity features. At the same time they have inflammation effects on the endothelium . Especially in applications related to veins results that make them more preferable are obtained.
EXPLANATI ON OF DRAW I NGS
Figure 1 : Example of glue application by following catheter with pressure apply
Figure 2: Gun with Adaptor : Right side view Figure 3: Gun with Adaptor : Left side view Figure 4: Gun without adapter Figure 5: Adaptor : Side view Figure 6: Adaptor : Front view
Figure 7: Adaptor locking mechanism to the gun DETAI LED DESCRI PTI ON OF TH E I NVENTI ON
The glue subject to the invention is used to prevent the formation of varicose veins/ to stop it from progressing, to treat varicose veins and to seal vena saphena magna. Butyl based cyanoacrylic (N-Butyl-2-Cyanoacrylate) groups show more elasticity characteristics and as a result they are preferred in such applications. Dimethyl sulfoxide (DMSO) is used as solvent for the cyanoacrylates to adjust the viscosity. DMSO is preferred because of its biocompatibility. I n order to apply the procedure, cyanoacrylate application adjusted to a dose in compliance with the vein diameter based on Table 1 , is carried out under ultrasound under the observation of a doctor at each 4cm from the starting point of the sapheno femoral junction to the end of said section.
Preferably Octyl-2-cyanoacrylate comprising and octyl group is used as it is elastic such that it fills the aneurysm (By taking Table 2 as reference) when treating aneurysms with glues that can occur in cerebral veins.
Moreover cyanoacrylate is also used in the following applications:
• As an adhesive in inguinal hernia operations with surgical mesh support during either traditional or laparoscopic surgery,
• When stopping the hemorrhaging of liver sections ,
I n order to stop hemorrhaging at the gallbladder base during traditional and laparoscopic surgery,
I n order to stop hemorrhaging and to repair the lesions or to stick parenchyma tissue in hemorrhagic lesions of the liver, kidneys, pancreas and the spleen
When sealing and strengthening gastrointestinal anastomosis
When stopping hemorrhaging in portocaval anastomosis
Sealing appendicitis roots.
As a sealer in the reconstruction of the rectovaginal septum
When sealing anastomosis during the reconstruction of the gall bladder and the pancreas channel
When treating lymphorrhagia that has occurred in the armpit and the inguinal hernia
Generally when strengthening the aortic and vascular sutures
When repairing the small lesions on the pericardium without using sutures
As an adhesive to determine the adaptation period of arterial bypasses placed into the heart and to improve said bypasses, together with stopping hemorrhage and strengthening anastomosis during arterial bypass applications of the heart
Re-covering the perianeurysmal tissue during ventricular aneurysm surgery
Adhering the patch and strengthening sutures during left ventricle reduction
As an adhesive in order to adhere the dissection plane in acute aorta dissections As an anti hemorrhagic when preventing hemorrhaging of the proximal and distal anastomosis in acute aorta dissections
When adhering the patch that it to be placed in order to strengthen the dissected aorta As an anti hemorrhagic of anastomosis during aorta valve surgery and especially when encountering atheromathous aorta.
As an anti hemorrhagic and in order to strengthen sutures following aortic aneurysm repair
As an anti hemorrhagic adhesive following re-operations due to lacerations occurring in the ventricle during re-sternotomy or adhesions
Providing aerostasis during lung resections, lobectomy, pneumo nectomy, bullectomy, volume reduction interventions and trachea bronchial resections, and when sealing off and strengthening sutures or staples in order to ensure improved running or mechanic closing
I n order to seal and strengthen vascular sutures during lung transplantations.
I n order to seal and strengthen sutures following trachea resections
As an anti hemorrhagic during venous bleeding following dissection and extraction (such as decortications, adhesions, tumors, mediastinal tumors, and impaired pleural cavities) · To seal off bronchial and bronchopleural fistulas
I n order to seal BOS fistulas following nasal-paranasal sinus and hypophysis operations
I n order to close Pharyngocutaneous fistulas; and sealing the saliva channels during nasal-pharynx cavity and oral cavity operations.
· Sealing off discharge occurring after ear operations or ear trauma.
I n order to treat seromas occurring after lymph node, and lateral neck and collarbone lymphorrhagia
As an anti hemorrhagic to be used on the hemorrhagic surfaces of oral and pharynx cavities Ethyl-2-Cyanoacrylate is preferred due to fast results in such applications.
As a surface sealer in order to prevent BOS fistulas used together with haemostatic fabric and tampons that can be absorbed in order to protect the cerebral parenchyma during cranial, and spinal dural plastic surgery
As a sealer of the cavities that occur following the extraction of tumors in dural plastic surgeries
As a sealer of dural lacerations occurring following hemilaminectomy surgeries.
I n order to seal off sella turcica, by trans sphenoidal route
Adhering bone and bone-cartilage parts
Adhering intercostals and cervical muscles
Used in order to selectively adhere bone opercula
Methyl cyanoacrylate is preferred as it is resistant and shows fast results.
Treating myoma in gynecology
As an anti hemorrhagic and adhesive used during vaginal and perineal plastic surgeries
I n order to stop vaginal bleeding following hysterectomy and urethral cystopecsy Sealing off and stopping venous hemorrhaging
As a sealer and anti hemorrhagic in reconstructive surgery following extirpative oncological
Octyl- 2- Cyanoacrylate is preferred due to elasticity.
Sealing sutures made to prevent urinary incontinence
Adhering and stopping hemorrhaging following kidney transplants and nephrolithotomy operations
As a sealer and anti hemorrhagic of kidney lacerations and hemorrhagic lesions Treating urinary fistulas
Sealing off the excretion channel during partial nephroctomy operations and stopping hemorrhaging
Lymphorrhagia treatment following surgery
Octyl-2-Cyanoacrylate is preferred due to elasticity.
I n order to endoscopically treat the esophagus, esophagotrachial, gastric, gastro intestinal, duodenal and pancreatic fistulas I n order to endoscopically treat gastric, duodenal and peptic ulcers
I n order to endoscopically treat esophagus, gastric and duodenal varicose
N-Butyl-2-Cyanoacrylate group is preferred due to its fast effects and elasticity.
N-Butyl-2-Cyanoacrylate is preferred as it has fast effects and shows elasticity in arterial and venous embolization.
Although there is an application difference in all product groups, the system features are based on the same principle. According to application the delivery catheter and the introducer sheath lengths and diameters change although the material they are formed of does not change. The selection of materials to be used during procedures is important as it should not react to the cyanoacrylic agent. At the same time these agents also need to be complaint for sterilization.
a. I ntroducer Sheath (introducer catheter) selection: I t is not important if the introducer sheath is reactive to the cyanoacrylic agent or not as it does not have contact with said agent. However it is important that it is compliant with blood and the fact that it can be moved forward as it will be used inside the vein lumen.
Polyethylene raw material has been used to achieve this. The most suitable density in terms of rigidity has been found.
Connector parts have been attached to the ends of the produced sheaths so that they can be attached suitably to the other system parts. Finally in order to provide practical usage, each cm on the sheath has been marked.
b. Delivery catheter: This is the system that shall carry the cyanoacrylic agent to the area of application. I t is important that this catheter does not react to the cyanoacrylic agent. For this reason the usage of a 4F (4 French) diameter FTFE catheter has been preferred.
Before deciding on using PTFE, polyurethane and pebax alternatives have been chosen, however due to their reactive characteristics suitable results have not been obtained.
c. Polymer container: I s a system that shall store the cyanoacrylic agent. I t is important that it does not show reaction to the cyanoacrylic agent. At the same time it should allow EO sterilization and should protect the cyanoacrylic polymer from reaction. For this reason container produced from HDPE have been preferred. LDPE and PU and PA materials have been tried but the results were not healthy.
With this invention continuous application procedure have been developed especially for the treatment of long vessel segment.
Purpose of this new model is delivering agent inside of the vein lumen with fixed amount of dosage while pulling back the delivery catheter inside of the vessel lumen simultaneously.
System consistent of an entry catheter, which advances through vessel lumen, a PTFE (polytetrafluoroethylene) delivery catheter with application gun that will deliver decided dose of cyanoacrylate according to the vessel diameter to the vessel lumen and specialty of system is the continuous application of cyanoacrylate while pulling the trigger and pulling back the delivery catheter continuously and simultaneously.
Adaptor is the part that connects syringe to the gun. I t is adaptable to the all universal injectors. I t has special spin-lock mechanism.
When the trigger of the system pulled and hold glue is applied through the catheter. Catheter should be pull back simultaneously.
When the trigger of the system pulled and hold for 1 - 10 seconds, catheter pulled- back by 1 - 10 cm per second and during the pull-back catheter applies 0.01 - 0.5 ml glue. For example, while holding the trigger of the gun for 5 seconds catheter should be pulled back by 2 cm / sec. Thus, trigger push and hold for 5 seconds applies glue to the 10 cm vessel segment and the amount of applied glue is 0.03 ml per cm and 0.3 ml per 10 cm .
The other application of the device with the glue injection and catheter pullback mechanism is continuous pressure applied over the vein by hand or ultrasound probe over the vessel following catheter pullback cycle.
This technique provides lower complication rates and higher vessel closure rates while giving minimum foreign material injection inside of the body. Additionally patient comfort and life score is increasing.
Another advantage of the invention is closure of the vessel is looks like a string. I n this kind of other closure techniques, vessel lumen is thrombosed and looks like a circle filled inside under the ultrasound. This thrombus inside of the vein starts a thrombosis mechanism and closes the vein in the long term. With this invention vessel closure provides instantly and thrombosis mechanism is cancelled and / or decreased to minimum. Thus vessel closure is gained by endothelium damage without thrombosis function instantly.

Claims

CLAI MS
Surgical glue application gun comprising introducer catheter, that allows catheter advance through the vessel, and PTFE (polytetrafluoroethylene) delivery catheter that delivers adjusted dose of n-butyl-cyanoacrylate according to the vessel diameter to the application site characterized in that when trigger is pulled continuously, said catheter is pulled back with continuous and simultaneous glue delivery.
Surgical glue application gun according to the Claim 1 , comprising adapter that connects injector to the gun.
Surgical glue application gun according to the Claim 1 wherein, catheter should be pulled-back by 1 -10 cm/sec when trigger is pulled for 1 -10 seconds.
Surgical glue application gun according to the Claim 2, wherein catheteher applies 0.01 - 0.5 ml glue per second during pull-back.
Surgical glue application gun according to the Claim 1 , wherein introducer catheter is polyethylene.
Surgical glue application gun according to the Claim 1 , wherein delivery catheter is 1 - 10 French diameter.
PCT/TR2015/050037 2015-07-15 2015-07-15 Surgical glue application gun WO2017010953A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/TR2015/050037 WO2017010953A1 (en) 2015-07-15 2015-07-15 Surgical glue application gun

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Application Number Priority Date Filing Date Title
PCT/TR2015/050037 WO2017010953A1 (en) 2015-07-15 2015-07-15 Surgical glue application gun

Publications (1)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019086815A1 (en) 2017-11-06 2019-05-09 Safran Composite part with integrated electronic instrumentation circuit and method for manufacturing the same
WO2019186465A1 (en) 2018-03-29 2019-10-03 Primequal Sa Tip and device for applying and spreading a liquid, gel or paste product
CN110680416A (en) * 2019-10-25 2020-01-14 苏州特普新智能科技有限公司 Lower limb varicose vein sealing mechanism and sealing method
CN112294492A (en) * 2020-10-30 2021-02-02 北京福爱乐科技发展有限公司 Fixing method of hernia surgical patch based on medical glue

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WO2013013080A1 (en) * 2011-07-20 2013-01-24 Sapheon, Inc. Enhanced ultrasound visualization of intravascular devices
WO2015122859A1 (en) * 2014-02-14 2015-08-20 Fg Grup Saglik Insaat Harita Mimarlik Muhendislik Elektronik Sanayi Ve Ticaret Ltd. Sti. System used in vein treatment

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019086815A1 (en) 2017-11-06 2019-05-09 Safran Composite part with integrated electronic instrumentation circuit and method for manufacturing the same
WO2019186465A1 (en) 2018-03-29 2019-10-03 Primequal Sa Tip and device for applying and spreading a liquid, gel or paste product
CN110680416A (en) * 2019-10-25 2020-01-14 苏州特普新智能科技有限公司 Lower limb varicose vein sealing mechanism and sealing method
CN110680416B (en) * 2019-10-25 2024-05-10 天琴特普新医疗科技(苏州)有限公司 Lower limb varicose vein sealing mechanism and sealing method
CN112294492A (en) * 2020-10-30 2021-02-02 北京福爱乐科技发展有限公司 Fixing method of hernia surgical patch based on medical glue

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