WO2017003137A1 - Fast disintegrating granular hair cleansing composition - Google Patents

Fast disintegrating granular hair cleansing composition Download PDF

Info

Publication number
WO2017003137A1
WO2017003137A1 PCT/KR2016/006756 KR2016006756W WO2017003137A1 WO 2017003137 A1 WO2017003137 A1 WO 2017003137A1 KR 2016006756 W KR2016006756 W KR 2016006756W WO 2017003137 A1 WO2017003137 A1 WO 2017003137A1
Authority
WO
WIPO (PCT)
Prior art keywords
ring
fast disintegrating
granules
cleaning composition
acid
Prior art date
Application number
PCT/KR2016/006756
Other languages
French (fr)
Korean (ko)
Inventor
정주아
최양규
김현나
배준호
Original Assignee
(주)아모레퍼시픽
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020160078679A external-priority patent/KR20170003414A/en
Application filed by (주)아모레퍼시픽 filed Critical (주)아모레퍼시픽
Priority to JP2017568067A priority Critical patent/JP2018527307A/en
Priority to CN201680048775.3A priority patent/CN107920962A/en
Priority to US15/740,339 priority patent/US20180193231A1/en
Publication of WO2017003137A1 publication Critical patent/WO2017003137A1/en

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/362—Polycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/02—Preparations for cleaning the hair

Definitions

  • the present invention relates to a fast disintegrating granular ring hair cleaning composition which disintegrates rapidly and has increased portability, hygiene and ease of use.
  • Contamination of the scalp and hair includes secreted sebum sweat and residues of dead keratinocyte hair cosmetics. Severe contamination of the scalp leads to clogged hair follicles (hair papilla) function is reduced, the normal growth of the hair is interrupted, causing hair loss. By removing these substances, the hair is clean and the pores that block the pores are removed to improve blood circulation, and oxygen is used to make hair and scalp healthy.
  • shampoos suitable for dry hair, oily hair, dyed hair, neutral hair, damaged hair, etc., depending on the hair type are available.
  • a functional shampoo having various functions such as a hair loss shampoo for preventing hair loss, a dandruff shampoo for removing dandruff.
  • shampoos are generally milky liquid forms, and various types of shampoos that are easy to use, such as a spray type and a solid type, are also commercially available.
  • Spray-type shampoo is called 'dry shampoo' and is sprayed onto the scalp. This spray type shampoo is used to remove the overall oiliness of the hair, and there is no substantial hair and scalp cleaning.
  • Shampoo of the solid type is manufactured in the form of a shampoo bar, and has the advantage of being easy to use and free of worries like liquid shampoo.
  • the shampoo bar has a stiff feeling after use and is vulnerable to water, and the longer the use time, the more the form is lumped, and the water must be constantly rubbed with water for use, and it is unsanitary due to repeated use.
  • the foamed solid shampoo is prepared by mixing a foaming agent for foaming, an interfacial detergent for washing and a disintegrating agent together with a binder to prepare a powder form, and agglomerating the powder through a process such as compression molding.
  • the foamed solid shampoo prepared above is mixed with water to generate foam before use, and hair washing is performed using the foam.
  • Such a foamed solid shampoo has an advantage in that it solves problems such as agglomeration in the form of a conventional solid type shampoo, but it takes a certain time before water used for foaming penetrates into the solid shampoo. This causes the hassle of breaking physical force.
  • the present invention was devised by introducing the pharmaceutical wet granules manufacturing method in the preparation of the detergent to solve the above problems, by introducing a wet granulation process of the pharmaceutical formulation technology into the detergent manufacturing process sokbung granules ring hair cleaning composition
  • a wet granulation process of the pharmaceutical formulation technology into the detergent manufacturing process sokbung granules ring hair cleaning composition
  • it was easily disintegrated with a small force, so that the cleaning component could be easily eluted, and thus, it was newly confirmed that portability, ease of use, and hygiene could be improved when molded in a single use amount. .
  • the present invention provides a fast disintegrating granular ring hair cleaning composition, characterized in that the granules comprising a surfactant, a blowing agent and a disintegrant are bonded to each other by a binder to have a pill (pill) formulation. do.
  • (V) provides a method for producing a fast disintegrating granules ring hair cleaning composition comprising the step of compression molding the resulting mixture using a mold.
  • the fast disintegrating type granular ring hair cleaning composition according to the present invention may be easily decomposed and creamy bubbles when contacted with water.
  • the fast disintegrating granular ring hair cleaning composition prepared by the wet granulation process and divided into a predetermined amount is easily disintegrated into granules with a small force, and the surface surface in contact with water can be quickly disintegrated.
  • composition for fast disintegrating granular ring hair cleaning of the present invention in one portion using a whole amount at a time, portability, ease of use and hygiene can be improved.
  • the fast disintegrating granular ring hair cleaning composition of the present invention is prepared by adding functional additives such as a hair conditioning agent, various additional functions such as stiff usability due to powder raw materials may be improved or supplemented.
  • 1 is an image showing the shape of the fast disintegrating granular ring hair cleaning composition according to the present invention.
  • Figure 2 is a flow chart showing the manufacturing process of the fast disintegrating granules ring hair cleaning composition according to the present invention.
  • Figure 3 is an image showing the manufacturing process of the fast disintegrating granular ring hair cleaning composition according to the present invention.
  • Figure 4 is a data showing the hardness according to the falling distance of the fast disintegrating granular ring hair cleaning composition according to Example 1 of the present invention and the powder ring cleaning agent according to Comparative Example 1.
  • Example 6 is an image showing the properties after the preparation of the fast disintegrating granular ring hair cleaning composition according to Example 1 of the present invention, when disintegrating and reacting with water.
  • the present invention provides a fast disintegrating granular ring hair cleaning composition.
  • the fast disintegrating granular ring hair cleaning composition is a wet granulation process, which is a pharmaceutical manufacturing method, is introduced into the detergent manufacturing method, so that the hardness is low, and the disintegration time is easily induced even with a small force. Increase convenience
  • 'fast disintegrating foam' referred to in the present invention means being easily converted to foam by water
  • 'hair cleaning composition' means a shampoo composition for hair cleaning.
  • the 'fast disintegration type foam hair cleaning composition' referred to in the present invention is prepared in a ring formulation, wherein the composition is 'ring formulation solid shampoo', 'fast disintegration type granule ring cleaner', 'fast disintegration granules' It may be referred to as ring cleaner, 'blow disintegration foam granule ring', 'foamed ring solid shampoo', 'shampoo ring' or 'shampoo foam ring'. Hereinafter, it is referred to as 'fast disintegrating granule ring cleaner'.
  • the term 'fast disintegrating type' or 'fast disintegration' referred to herein means a property for satisfying the requirement that the fast disintegrating granule ring cleaner proposed in the present invention is rapidly dissolved and foamed.
  • the fast disintegrating property is obtained by measuring the disintegration time until the fast disintegrating granular ring detergent having a diameter of 18 to 25 mm, preferably 20 mm, is completely decomposed within a temperature of 25 to 35 ° C., preferably 30 ° C. If the disintegration time is within 20 seconds, preferably within 10 seconds, it means fast disintegration.
  • the term "hardness" refers to maintaining the formulation and feeling of use, and refers to the strength required for disintegration of the fast disintegrating granular ring detergent.
  • the hardness can be adjusted through the particle size and particle size distribution of the granular ring, it can be applied at the time of setting the force required for compression compared to the weight during molding.
  • Hardness in the present invention is measured by using a texture analyzer (TA) to obtain a numerical value of g, 500g or less, preferably 450g or less 50g or more, more preferably 300g or less 100g or more.
  • TA texture analyzer
  • the hardness is too low, it is difficult to maintain the ring shape, it is desirable to satisfy the minimum value.
  • Sokbung granules ring hair cleaning composition Sokbung granules ring hair cleaning composition
  • the fast disintegrating granule ring detergent is prepared by compressing the powder form by mixing a surfactant for cleaning, a blowing agent for foaming and a disintegrating agent for disintegration with a binder, but it is inconvenient to use because water is not easily penetrated into the shampoo. There was a problem. Therefore, in the present invention, it is manufactured in the form of granules, not in powder form, followed by compression molding to form a pill form.
  • the fast disintegrating granule ring detergent prepared after the first preparation in the form of granules forms a plurality of sex channel water channels due to the granules in the structure to maintain a certain level of voids.
  • Water quickly penetrates and moves into the voids and the water channels therein, causing the granules to disintegrate due to the water to occur almost simultaneously throughout the ring formulation, greatly reducing disintegration time, as well as low granules, making the granules less easily with less force. Disintegration into may further shorten the disintegration time.
  • the composition constituting the granules includes a surfactant, a blowing agent and a disintegrant.
  • the surfactant of the present invention means a compound having a hydrophilic part which is easily dissolved in water and a hydrophobic (lipophilic) part which is easily soluble in oil as a composition for imparting cleaning power.
  • Such surfactants may be selected in consideration of the use of detergents, anionic surfactants, cationic surfactants, amphoteric surfactants, nonionic surfactants or mixtures thereof.
  • Anionic surfactants are anions when dissociated in water, cationic surfactants are cations, and amphoteric surfactants have both anion or cationizable moieties in the molecule.
  • Anionic, nonionic surfactant may mean that the hydrophilic portion is a non-electrolyte, i.e., a hydrophilic portion that does not ionize, and may also include fatty acids in the acid state rather than the salt state.
  • an alkyl sulfate having a carbon number of C12 (lauryl) to C18 (stearyl) or a sulfate added with 2 to 5 polyoxyether groups can be mainly used.
  • anionic surfactants having excellent foaming power and detergency can be used in the composition of the present invention.
  • anionic surfactants having excellent foaming power and detergency include aliphatic sulfonates, aromatic sulfonates, alkyl sulfates, alkyl ether sulfates, alkyl sulfosuccinates, alkyl and acyl taurates, alkyl and acyl sacosinates, and sulfoacetates.
  • an amphoteric surfactant, a nonionic surfactant, etc. can be mixed and used in addition to an anionic surfactant, and it is used in a cleaning composition, If it has a bubble enhancement effect, it will not specifically limit.
  • the amphoteric surfactant alkyl betaine, alkyl sulfate, alkyl amidopropyl betaine, alkyl amidopropyl hydroxy sulfate, alkyl ampoacetate, alkyl diamphoacetate and the like can be used.
  • usable nonionic surfactants include, for example, alkyl glucose amides, alkyl glucose esters, polyoxyethylene esters, fatty acid alkylamides, alkyl amine oxides, alkyl polyglucosides, polyoxyethylene ester fatty acids, and the like.
  • the surfactant is preferably contained in 5 to 55% by weight, preferably 7 to 30% by weight based on the total weight of the fast disintegrating granular ring detergent to ensure a cleaning effect. If the content is less than the above range, a sufficient cleaning effect cannot be secured. On the contrary, if the content exceeds the above range, it may be harmful to the skin due to excessive cleansing power, giving a damp feeling of use, and likely remaining on the skin or hair. .
  • the blowing agent applied to the present invention is a principle in which the inorganic carbonate and the weak acid react to generate carbon dioxide (CO 2 ), so that the fast disintegrating granule ring detergent can be rapidly foamed and disintegrated in water.
  • Inorganic carbonates include sodium bicarbonate (NaHCO 3 ), potassium bicarbonate (KHCO 3 ), calcium bicarbonate (Ca (HCO 3 ) 2 ), sodium carbonate (Na 2 CO 3 ), potassium carbonate (K 2 CO 3 ), calcium carbonate (CaCO 3 ) or mixtures thereof, preferably sodium bicarbonate (NaHCO 3 ) is applied.
  • the weak acid may be at least one selected from citric acid, tartaric acid, phosphoric acid, acetic acid, maleic acid, and fumaric acid. Although not limiting in the present invention, citric acid is preferably applied.
  • the blowing agent is contained in 10 to 50% by weight, preferably 15 to 45% by weight of the total weight of the disintegrated granule ring detergent, wherein inorganic carbonate and weak acid are used in 5 to 45% by weight, respectively, more preferably Inorganic carbonate: It is preferable to use a weak acid in a weight ratio of 1: 0.1 to 1: 0.6 in order to generate carbon dioxide and to secure a foaming force. If the content of the blowing agent is less than the above range, sufficient bubble formation is difficult and the feeling of use decreases. On the contrary, if the above foaming range is exceeded, this also causes a decrease due to excessive bubble formation.
  • Disintegrants applied in the present invention are generally used in the pharmaceutical field and are expanded in volume by moisture.
  • the disintegrant is at least one selected from starches, microcrystalline cellulose, crospovidone, low-substituted hydroxypropyl cellulose and croscarmellose. This is possible but not limited to.
  • the disintegrant is used in an amount of 1 to 25% by weight, preferably 5 to 20% by weight, based on the total weight of the fast disintegrating granular ring detergent. If the content is less than the above range, the disintegration rate of the granule ring is slow, and if the content exceeds the above range, it is not easy to control the disintegration rate.
  • Granules comprising the surfactant, blowing agent and disintegrant are prepared using a wet granulation process, which is the pharmaceutical preparation described below, and is prepared in various forms.
  • the granules may be spherical or cylindrical (or pelletized), and cylindrical is more advantageous when considering water channel formation or pore characteristics.
  • These granules have a particle diameter of 0.1 to 3.0 mm, preferably 0.5 to 1.5 mm in the case of spheres.
  • the cylindrical type has a particle diameter of 0.1 to 3.0 mm, preferably 0.5 to 1.5 mm, a length of 0.2 to 5.0 mm, preferably 0.7 to 3.0 mm. If the particle size and length of the granules are less than the above range, fluidity decreases in the granulation process, and agglomeration between granules occurs.
  • the size and shape of the granules can be controlled in the granulation process of extruding through a sieve to make granules during the wet granulation process.
  • granules are bound by a binder to form a fast disintegrating granule ring detergent.
  • the binder is used to aid adhesion between the granules and to maintain the formulation after compression.
  • the binder which can be used one or more selected from 1,3-butylene glycol, dipropylene glycol, propylene glycol, polyethylene glycol and other liquid polyols may be used as glycerin, silicone oils, polyols and combinations thereof. It may be possible to.
  • the binder maintains a certain level of pores and water channels by the granule rings of the fast disintegrating granule ring cleaner, and limits its content so that the pores and water channels can be maintained in the final molding process.
  • the binder is used in an amount of 1 to 30% by weight, preferably 5 to 20% by weight, based on the total weight of the fast disintegrating granular ring detergent. If the content is less than the above range, there is a risk of collapse during the molding process due to difficulty in bonding or adhesion between granules. On the contrary, when used in excess of the above range, pores and water channels decrease, so that fast disintegration characteristics cannot be obtained. It has a loose feel.
  • the fast disintegrating granule ring cleaning agent of the present invention may further include an additive such as a thickener for adjusting the viscosity of the cleaning composition as described above or a bubble stabilizer for stabilizing the bubbles as necessary.
  • a thickener for adjusting the viscosity of the cleaning composition as described above or a bubble stabilizer for stabilizing the bubbles as necessary.
  • the thickener is to form a high viscosity mucus by dissolving in water or an organic solvent, to increase the viscosity of the detergent, bentonite, clay, silica, acrylic polymer, vinyl polymer, cellulose and gum can be used, Lauric acid can be used as a bubble stabilizer.
  • the fast disintegrating granule ring cleaner of the present invention is a hair cleaner, it may further include a hair conditioning agent that imparts shine, softness, antistatic and elasticity to the hair.
  • Hair Conditioning Agents Glycerin, Guarquat, Cationic Polymer, Alkyl trimethyl ammonium chloride (ATAC), C10-C22 Dialkylmethylammonium Chloride (DDAC), Behenyltrimethyl Ammonium chloride (Behenyltrimethylammonium Chloride, BTAC), Stearyltrimethylammonium Chloride (STAC), Tricetylmethylammonium Chloride (TCMAC) may be used alone or in combination.
  • Glycerin, Guarquat, Cationic Polymer Alkyl trimethyl ammonium chloride (ATAC), C10-C22 Dialkylmethylammonium Chloride (DDAC), Behenyltrimethyl Ammonium chloride (Behenyltrimethylammonium Chloride, BTAC), Stearyltri
  • the fast disintegrating granular ring detergent of the present invention is a component that does not lower the cleaning power and foaming power of the cleaning agent in order to provide the appropriate volume feeling and to fill the mold, lactose, mannitol, starch, sorbitol, crystalline cellulose, It is possible to use at least one filler selected from polypyrrolidone and hydroxymethyl cellulose.
  • the fast disintegrating granule ring cleaner of the present invention may include additives commonly used in the art, and may include, for example, one or more additives selected from preservatives, flavoring agents, pH adjusting agents, viscosity adjusting agents, humectants, and fungicides. Can be. Such additives may be included, for example, within the range of 0.001 to 10% by weight, depending on the type of each additive based on the total weight of the fast disintegrating granular ring cleaner according to the present invention.
  • the fast disintegrating granule ring cleaner according to the present invention having the composition as described above is rapidly disintegrated through rapid water penetration into and out of the granular shell when contacted with water, and the hardness is low so that disintegration into granules is easy even with low force. After the creamy cream is generated.
  • Such fast disintegrating granule ring cleaning agent is divided and molded into one portion, preferably 1 to 5g, more preferably 2 to 3g in one portion. In this case, after contact with water at 25 to 35 ° C., little force is applied and the small granules rapidly react with water to form bubbles and have a disintegration time of 5 to 15 seconds, preferably 10 seconds or less.
  • the single dose may be made larger or smaller than the above range in consideration of hair length or thinning.
  • a fast disintegrating granule ring detergent in the form of a spherical ring it is possible to produce a diameter of 18 to 25 pies ( ⁇ ), and for short hairs to have a diameter of 20 to 22 pies using 2 to 3 g. Manufacture.
  • 1 phi ( ⁇ ) means a diameter of 1mm, it means that the batch disintegrating granules detergent may have a diameter of 18 to 25mm.
  • the fast disintegrating granule ring cleaning agent of the present invention is not limited in its use or shape, and any form can be used as long as it can be produced by the pharmaceutical wet granulation method.
  • the fast disintegrating granule ring cleaner is spherical, spherical, hemispherical, cylindrical, rugby ball type, conical, cylindrical, polygonal, trapezoidal, square shape, cuboid, etc., if any form can be satisfied with the user and excellent feeling It is not limited.
  • in the embodiment of the present invention was produced in a spherical shape.
  • the fast disintegrating granule ring detergent may be coated with a coating of the formulation with a material such as an oil having a water resistance, or a lubricant or silica to stabilize moisture of the formulation. It is also desirable to select a packaging material to maintain moisture stabilization and hardness in the packaging of the product. For example, a multi-pocket type packaging material in which a plurality of dosage forms are packaged, a dispenser packaging material in which one dosage form is discharged in one touch, or a peel off type plastic packaging material (eg, Blister Package) may be applicable.
  • Sokbung granules ring cleaner of the hair cleaning composition Manufacturing method
  • the fast disintegrating granule ring cleaner presented above has a form in which granules are bound by a binder, which is prepared in particular by pharmaceutical wet granulation.
  • the wet granulation process consists of the weighing and mixing of the raw material components, the assembling process, the assembly process, the drying process and the sizing process.
  • This wet granulation process has the advantage of ensuring the fluidity of the powder, increase the density of the raw material, and improve the compressibility.
  • the granules are first prepared, and the granules are prepared by using a binder for granulation. An amount of fast disintegrating granules ring detergent is prepared.
  • the fast disintegrating granule ring cleaning agent of the present invention is divided into granulation step and molding step, and since the disintegration occurs in contact with water, these processes are prepared in anhydrous formulations excluding the use of water.
  • Figure 2 is a flow chart showing the manufacturing process of the fast disintegrating granules ring cleaning agent according to the present invention
  • Figure 3 is an image.
  • a surfactant, a blowing agent, and a disintegrant are added to the mixer, and then mixed uniformly to prepare a mixture (see FIG. 3 (a)).
  • each composition is used within the composition and content range of the bar described above.
  • step (i) After the wetting agent is added to the mixture obtained in step (i), a dough is prepared through a kneading process (see FIG. 3 (b)).
  • an anhydrous binder liquid without water is used as a liquid material for evenly mixing the raw materials and bonding them.
  • the anhydrous binder solution at least one selected from ethanol, methanol, and acetone, which are relatively low in toxicity and volatile, may be used.
  • ethanol is used.
  • the humectant is used in an amount of 1 to 50 parts by weight, preferably 5 to 25 parts by weight, based on 100 parts by weight of the total composition of the granules. If the content is less than the above range, there is a possibility that the binding of the raw materials is insufficient, and the shape may be broken during the preparation of the granules.
  • Such a kneading process may use a known kneader, and for example, a kneader or ponymixer may be used.
  • granules are prepared by performing an extrusion granulation process and a drying process of passing the dough kneaded in step (ii) to a screen (see FIGS. 3 (c) and (d)).
  • a sieve of 0.5 to 1.5 mesh is generally used, and the particle size of the final granules varies depending on the size.
  • Drying is carried out at a temperature at which the wetting agent in the granules can be sufficiently removed, preferably at 25 to 80 ° C. for 0.5 to 5 hours. Such temperatures and times can be altered by one of ordinary skill in the art for the removal of humectants.
  • Granulator for producing the granules may be used granulators commonly used in the pharmaceutical field, it is not particularly limited in the present invention.
  • step (iii) the binder is added to the granules obtained in step (iii) and mixed uniformly (see FIG. 3 (e)).
  • the binder is used by weighing the raw material as described above.
  • the binder may be administered at once or divided doses.
  • the mixer is not particularly limited, and a high speed mixer, a double cone mixer, a cone blender, a ribbon blender, a shovel mixer, a pug mixer-Henschel mixer, a brabender, a biaxial mixer, or the like can be used.
  • step (iv) the mixture obtained in step (iv) is compression molded using a mold to prepare a fast disintegrating granule ring detergent of a pill formulation (see FIGS. 3 (f) and (g)).
  • the compression molding is performed by applying a pressure after injecting a mixture into a mold.
  • the applied pressure may be a level at which the mixture is sufficiently combined to be formed into a predetermined shape, and depends on the size of the mold. If the applied pressure is insufficient, so that the damage or cracking occurs when using or storing the fast disintegrating granular ring detergent is performed properly.
  • the fast disintegrating granule ring cleaner prepared by the above-described steps is prepared by applying a pharmaceutical wet granulation process, and is a form in which granules are aggregated together rather than powders in a conventional manner.
  • One pore is formed, and a water channel is formed, which breaks easily into small granules with little force upon contact with water, and these small granules disintegrate quickly to form creamy bubbles.
  • This allows the user to easily form the foam has the advantage of excellent ease of loosening, texture, etc. in the hand.
  • Sokbung granules were prepared in the composition of Table 1 below. At this time, each process follows the image shown in FIG.
  • Example 1 Comparative Example 1 Sodium Lauryl Sulfate (SLS) 13.4 15 Citric acid 6.35 7 Sodium bicarbonate 22.7 25 Starch 6.97 7.5 incense 0.13 0.15 STAC 80 (I) 0.45 0.5 Lactose 31 33.85 Guarco 2.3 2.5 glycerin 6.8 7.5 Silicone oil 0.9 One ethanol 9.0 - total 100 100
  • the average disintegration hardness was measured by a physical property analyzer, but the test speed was set to 2.00mm / sec, the target mode was set to Distance: 5.0mm, and the trigger type was set to Auto (Force): 0.049N.
  • the force required for ring disintegration was converted into mass (g), and the converted force according to the drop distance was shown in the data of FIG. 4.
  • the low hardness value measured here means that it can be easily collapsed with little force.
  • disintegration property and disintegration time were measured at the temperature (in water) of 30 degreeC.
  • Example 1 Comparative Example 1 Average Disintegration Hardness (g) 375 3250 Disintegration Disintegrates easily into granules Disintegrate into lumps Disintegration time 10 sec 20 minutes
  • the average disintegration hardness of the fast disintegrating granule ring cleaner is 375 g, which is light at about 1/10 of the disintegration hardness of the powder ring cleaner (Comparative Example 1). Disintegrated easily by force, the disintegrated image can be seen in FIGS. 5 and 6.
  • FIG. 5 is an image showing the properties after the preparation of the powder ring cleaner according to Comparative Example 1 of the present invention, when disintegrating and reacting with water.
  • the appearance After preparation of the powder ring cleaner of Comparative Example 1, the appearance has a dense and dense surface, and when disintegrated, a force expressed in mass of 3200 g was required, and the water disintegrated into a large mass, and the water penetrated into the disintegrated mass. It took a long time to dissolve completely for a difficult reason, and it was confirmed that it showed sticky feeling like porridge.
  • Figure 6 is an image showing the properties after the preparation of the fast disintegrating granules ring cleaning agent according to Example 1 of the present invention, when disintegrating and the reaction with water.
  • the rapid disintegrating granule ring cleaner of Example 1 forms pores on the surface and inside after preparation, and when disintegrated, it disintegrates into small granules with a force expressed by a mass of about 300 g, and in the water, small granules rapidly react with water. Foam was formed, it was confirmed that the loosening and foam formation in the hand is very excellent.
  • the fast disintegrating granular ring cleaner of the present invention is molded into a solid body while maintaining the intergranular voids due to granulation in the manufacturing process, the fast disintegrating granular ring detergent is significantly lower in hardness than the solid detergent compressed with the conventional powder, and disintegrates or dissolves in water.
  • the disintegration time can be shortened due to the small particle agglomeration phenomenon and excellent particle fluidity. Therefore, when the fast disintegrating granule ring cleaner of the present invention is divided into one portion and molded, portability, ease of use, and hygiene can be achieved.

Abstract

The present invention relates to a fast disintegrating granular hair cleansing composition in which a wet granulation process, which is a pharmaceutical preparation method, is introduced into a method for preparing a cleanser. The fast disintegrating granular hair cleansing composition is prepared by a wet granulation process so as to be readily disintegrated into granules by using small force, because of a low hardness thereof, and can easily form creamy foam since a large surface area comes into contact with water. In addition, portability, convenience of use and sanitation can be improved when molding is carried out in a single-dose in which the entire amount is used at one time.

Description

속붕해형 과립환 모발 세정용 조성물Sokbung granules ring hair cleaning composition
본 출원은 2015년 6월 30일자 한국 특허 출원 제10-2015-0092874호 및 2016년 6월 23일자 한국 특허 출원 제10-2016-0078679호에 기초한 우선권의 이익을 주장하며, 해당 한국 특허 출원의 문헌에 개시된 모든 내용은 본 명세서의 일부로서 포함한다.This application claims the benefit of priority based on Korean Patent Application No. 10-2015-0092874 filed on June 30, 2015 and Korean Patent Application No. 10-2016-0078679 filed on June 23, 2016. All content disclosed in the literature is included as part of this specification.
본 발명은 빠르게 붕해되고, 휴대성, 위생성 및 사용 편의성을 높인 속붕해형 과립환 모발 세정용 조성물에 관한 것이다. The present invention relates to a fast disintegrating granular ring hair cleaning composition which disintegrates rapidly and has increased portability, hygiene and ease of use.
두피와 모발의 오염에는 분비 배설된 피지 땀, 죽은 각질세포 두발 화장품의 잔류물 등이 있다. 두피의 오염이 심해지면 모낭이 막혀 모유두(hair papilla)의 기능이 저하되어 모발의 정상적인 발육이 방해되어 탈모를 일으킨다. 이러한 물질 등을 제거하여 모발을 청결하게 하고 모공을 막고 있는 물질을 없애줌으로써 혈행을 좋게 하며 산소 공급으로 모발과 두피를 건강하게 해 주기 위하여 샴푸를 사용한다.Contamination of the scalp and hair includes secreted sebum sweat and residues of dead keratinocyte hair cosmetics. Severe contamination of the scalp leads to clogged hair follicles (hair papilla) function is reduced, the normal growth of the hair is interrupted, causing hair loss. By removing these substances, the hair is clean and the pores that block the pores are removed to improve blood circulation, and oxygen is used to make hair and scalp healthy.
소비자의 니즈에 맞춰 다양한 형태의 샴푸가 시판되고 있으며, 일례로, 모발 타입에 따라 건성 모발, 지성 모발, 염색 모발, 중성 모발, 손상 모발 등에 적합한 샴푸가 있다. 또한, 탈모 방지를 위한 탈모 샴푸, 비듬 제거를 위한 비듬 샴푸 등 다양한 기능을 하는 기능성 샴푸가 있다.Various types of shampoos are commercially available in accordance with the needs of consumers, and for example, shampoos suitable for dry hair, oily hair, dyed hair, neutral hair, damaged hair, etc., depending on the hair type, are available. In addition, there is a functional shampoo having various functions such as a hair loss shampoo for preventing hair loss, a dandruff shampoo for removing dandruff.
통상 샴푸는 유백색의 액체 형태가 일반적이며, 스프레이 타입, 고체 타입 등의 사용이 간편한 다양한 형태의 샴푸 또한, 시판되고 있다. In general, shampoos are generally milky liquid forms, and various types of shampoos that are easy to use, such as a spray type and a solid type, are also commercially available.
스프레이 타입의 샴푸는 '드라이 샴푸'라고 일컬어지며, 두피에 스프레이 형태로 분사하여 사용한다. 이러한 스프레이 타입의 샴푸는 모발의 전체적인 유분감을 제거하기 위해 사용하는 것으로, 실질적인 모발 및 두피 세정은 이뤄지지 않는다. Spray-type shampoo is called 'dry shampoo' and is sprayed onto the scalp. This spray type shampoo is used to remove the overall oiliness of the hair, and there is no substantial hair and scalp cleaning.
고체 타입의 샴푸는 샴푸바(shampoo bar)의 형태로 제조되며, 사용이 간편하며 액체 샴푸처럼 샐 염려가 없다는 이점이 있다. 그러나 샴푸바의 경우 사용 후 뻣뻣한 느낌이 있으며 물에 취약하여 사용 시간이 길어질수록 형태가 뭉그러지고, 사용을 위해 물을 적셔 지속적으로 문질러야 하며, 반복 사용으로 인해 비위생적이라는 단점이 있다. Shampoo of the solid type is manufactured in the form of a shampoo bar, and has the advantage of being easy to use and free of worries like liquid shampoo. However, the shampoo bar has a stiff feeling after use and is vulnerable to water, and the longer the use time, the more the form is lumped, and the water must be constantly rubbed with water for use, and it is unsanitary due to repeated use.
최근에 고체 타입의 새로운 형태의 샴푸로서 바스밤(bath balm)이라는 발포형 고체 샴푸가 제안되었다. Recently, as a new type of shampoo of the solid type, a foamed solid shampoo called bath balm has been proposed.
발포형 고체 샴푸는 발포를 위한 발포제, 세정을 위한 계면세정제와 붕해제를 결합제와 함께 혼합하여 파우더 형태를 제조하고, 상기 파우더를 압축 성형 등의 공정을 통해 뭉침으로써 제조한다. 상기 제조된 발포형 고체 샴푸는 사용 전에 물과 혼합하여 거품을 발생시키고, 이 거품을 이용하여 모발 세정을 수행한다. The foamed solid shampoo is prepared by mixing a foaming agent for foaming, an interfacial detergent for washing and a disintegrating agent together with a binder to prepare a powder form, and agglomerating the powder through a process such as compression molding. The foamed solid shampoo prepared above is mixed with water to generate foam before use, and hair washing is performed using the foam.
이러한 발포형 고체 샴푸는 기존 고체 타입의 샴푸에서 발생하는 형태의 뭉그러짐 등의 문제를 해결한다는 점에서 이점이 있으나, 발포를 위해 사용하는 물이 고체 샴푸 내부로 침투되기까지 일정 시간이 소요되고, 이로 인해 물리적인 힘을 인가하여 깨뜨려야 하는 번거로움이 있다. Such a foamed solid shampoo has an advantage in that it solves problems such as agglomeration in the form of a conventional solid type shampoo, but it takes a certain time before water used for foaming penetrates into the solid shampoo. This causes the hassle of breaking physical force.
[선행기술문헌][Preceding technical literature]
[특허문헌][Patent Documents]
대한민국 특허등록 제10-123954호 (2013.02.27), 고형 샴푸 조성물Korea Patent Registration No. 10-123954 (2013.02.27), solid shampoo composition
본 발명은 상기의 과제를 해결하고자 상기 약제학적 습식 과립 제조법을 세정제 제조에 도입하여 안출된 것으로, 상기 약제학적 제형화 기술인 습식 과립 공정을 세정제 제조 공정에 도입하여 속붕해형 과립환 모발 세정용 조성물을 제조할 경우, 적은 힘으로 쉽게 붕해되어 세정 성분을 쉽게 용출시킬 수 있어서, 1회 사용 분량으로 성형할 경우에 휴대성, 사용 편의성 및 위생성을 향상시킬 수 있음을 새롭게 확인하여 본 발명에 이르게 되었다.The present invention was devised by introducing the pharmaceutical wet granules manufacturing method in the preparation of the detergent to solve the above problems, by introducing a wet granulation process of the pharmaceutical formulation technology into the detergent manufacturing process sokbung granules ring hair cleaning composition In the preparation of the present invention, it was easily disintegrated with a small force, so that the cleaning component could be easily eluted, and thus, it was newly confirmed that portability, ease of use, and hygiene could be improved when molded in a single use amount. .
따라서, 본 발명의 목적은 속붕해형 과립환 모발 세정용 조성물 및 이의 제조방법을 제공하는 것이다.Therefore, it is an object of the present invention to provide a fast disintegrating granular ring hair cleaning composition and a method for producing the same.
상기 목적을 달성하기 위해, 본 발명은 계면활성제, 발포제 및 붕해제를 포함하는 과립이 결합제에 의해 서로 결합되어 환(pill) 제형을 갖는 것을 특징으로 하는 속붕해형 과립환 모발 세정용 조성물을 제공한다. In order to achieve the above object, the present invention provides a fast disintegrating granular ring hair cleaning composition, characterized in that the granules comprising a surfactant, a blowing agent and a disintegrant are bonded to each other by a binder to have a pill (pill) formulation. do.
또한, 본 발명은In addition, the present invention
(i) 계면활성제, 발포제, 및 붕해제를 혼합하여 혼합 분말을 제조하는 단계;(i) mixing a surfactant, a blowing agent, and a disintegrant to prepare a mixed powder;
(ii) 상기 혼합 분말에 습윤제를 첨가하여 반죽을 수행하는 단계;(ii) adding a humectant to the mixed powder to perform a dough;
(iii) 얻어진 반죽물을 제립 후 건조하여 과립을 제조하는 단계;(iii) granulating and drying the obtained dough to prepare granules;
(iv) 상기 과립을 결합제와 혼합하는 단계; 및(iv) mixing the granules with a binder; And
(v) 얻어진 혼합물을 몰드를 이용하여 압축 성형하는 단계를 포함하여 제조하는 것을 특징으로 하는 속붕해형 과립환 모발 세정용 조성물의 제조방법을 제공한다. (V) provides a method for producing a fast disintegrating granules ring hair cleaning composition comprising the step of compression molding the resulting mixture using a mold.
본 발명에 따른 속붕해형 과립환 모발 세정용 조성물은 물과 접촉시 쉽게 분해되고 크리미(Creamy)한 거품을 형성할 수 있다. The fast disintegrating type granular ring hair cleaning composition according to the present invention may be easily decomposed and creamy bubbles when contacted with water.
또한, 습식 과립화 공정으로 제조되어 소정량으로 나누어 성형된 속붕해형 과립환 모발 세정용 조성물은 작은 힘으로 쉽게 과립으로 붕해되고, 물과 닿는 표면적이 넓어 빠른 붕해 과정이 이루어질 수 있다.In addition, the fast disintegrating granular ring hair cleaning composition prepared by the wet granulation process and divided into a predetermined amount is easily disintegrated into granules with a small force, and the surface surface in contact with water can be quickly disintegrated.
더욱이, 본 발명의 속붕해형 과립환 모발 세정용 조성물을 한 번에 전량을 사용하는 1회 분량으로 성형하면, 휴대성, 사용 편의성 및 위생성을 향상시킬 수 있다. Furthermore, by molding the composition for fast disintegrating granular ring hair cleaning of the present invention in one portion using a whole amount at a time, portability, ease of use and hygiene can be improved.
이에 나아가, 본 발명의 속붕해형 과립환 모발 세정용 조성물이 모발 컨디셔닝제 등의 기능성 첨가제를 추가하여 제조하면, 사용시 파우더 원료로 인한 뻣뻣한 사용감 등의 여러 추가 기능을 개선하거나 보완할 수 있다.Further, if the fast disintegrating granular ring hair cleaning composition of the present invention is prepared by adding functional additives such as a hair conditioning agent, various additional functions such as stiff usability due to powder raw materials may be improved or supplemented.
도 1은 본 발명에 따른 속붕해형 과립환 모발 세정용 조성물의 형상을 보여주는 이미지이다.1 is an image showing the shape of the fast disintegrating granular ring hair cleaning composition according to the present invention.
도 2는 본 발명에 따른 속붕해형 과립환 모발 세정용 조성물의 제조 순서를 보여주는 순서도이다.Figure 2 is a flow chart showing the manufacturing process of the fast disintegrating granules ring hair cleaning composition according to the present invention.
도 3은 본 발명에 따른 속붕해형 과립환 모발 세정용 조성물의 제조 공정을 보여주는 이미지이다. Figure 3 is an image showing the manufacturing process of the fast disintegrating granular ring hair cleaning composition according to the present invention.
도 4는 본 발명의 실시예 1에 따른 속붕해형 과립환 모발 세정용 조성물와 비교예 1에 따른 파우더환 세정제의 낙하 거리에 따른 경도를 나타낸 데이터이다.Figure 4 is a data showing the hardness according to the falling distance of the fast disintegrating granular ring hair cleaning composition according to Example 1 of the present invention and the powder ring cleaning agent according to Comparative Example 1.
도 5는 본 발명의 비교예 1에 따른 파우더환 세정제의 제조 후 성상, 붕해 시 성상 및 물과 반응 시 성상을 나타낸 이미지이다.5 is an image showing the properties after the preparation of the powder ring cleaner according to Comparative Example 1 of the present invention, when disintegrating and reacting with water.
도 6은 본 발명의 실시예 1에 따른 속붕해형 과립환 모발 세정용 조성물의 제조 후 성상, 붕해 시 성상 및 물과 반응 시 성상을 나타낸 이미지이다.6 is an image showing the properties after the preparation of the fast disintegrating granular ring hair cleaning composition according to Example 1 of the present invention, when disintegrating and reacting with water.
본 발명은 속붕해형 과립환 모발 세정용 조성물을 제공한다. 상기 속붕해형 과립환 모발 세정용 조성물은 약제학적 제조법인 습식 과립화 공정을 세정제 제조 방법에 도입하여 경도가 낮아 적은 힘으로도 쉽게 붕해를 유도함과 동시에 붕해 시간을 단축하고 휴대성, 위생성 및 사용 편의성을 높인다. The present invention provides a fast disintegrating granular ring hair cleaning composition. The fast disintegrating granular ring hair cleaning composition is a wet granulation process, which is a pharmaceutical manufacturing method, is introduced into the detergent manufacturing method, so that the hardness is low, and the disintegration time is easily induced even with a small force. Increase convenience
본 발명에서 언급하는 '속붕해 발포형'의 용어는 물에 의해 쉽게 거품으로 전환되는 것을 의미하며, '모발 세정용 조성물'은 모발 세정을 위한 샴푸 조성물을 의미한다.The term 'fast disintegrating foam' referred to in the present invention means being easily converted to foam by water, and 'hair cleaning composition' means a shampoo composition for hair cleaning.
또한, 본 발명에서 언급하는 '속붕해형 발포형 모발 세정용 조성물'은 환 제형으로 제조되며, 이때 상기 조성물은 '환 제형 고체 샴푸','속붕해형 과립환 세정제', '속붕해형 과립환 세정제', '속붕해 발포형 과립환', '발포환 고체 샴푸','샴푸환' 또는 '샴푸 발포환'으로 일컬어질 수 있다. 이하 편의를 위해 '속붕해형 과립환 세정제'라 한다.In addition, the 'fast disintegration type foam hair cleaning composition' referred to in the present invention is prepared in a ring formulation, wherein the composition is 'ring formulation solid shampoo', 'fast disintegration type granule ring cleaner', 'fast disintegration granules' It may be referred to as ring cleaner, 'blow disintegration foam granule ring', 'foamed ring solid shampoo', 'shampoo ring' or 'shampoo foam ring'. Hereinafter, it is referred to as 'fast disintegrating granule ring cleaner'.
본 명세서에서 언급하는 '속붕해형' 또는 '속붕해'의 용어는 본 발명에서 제시하는 속붕해형 과립환 세정제가 신속하게 용해되어 발포한다는 요건을 만족시키기 위한 특성을 의미한다. 속붕해형 특성은 18 내지 25mm, 바람직하기로 20mm의 직경을 갖는 속붕해형 과립환 세정제가 25 내지 35℃, 바람직하기로 30℃의 온도 내에서 완전히 분해될 때까진 붕해 시간의 측정을 통해 얻어질 수 있으며, 이때 붕해 시간이 20초 이내, 바람직하기로 10초 이내의 수치를 만족할 경우 속붕해성을 나타냄을 의미한다. The term 'fast disintegrating type' or 'fast disintegration' referred to herein means a property for satisfying the requirement that the fast disintegrating granule ring cleaner proposed in the present invention is rapidly dissolved and foamed. The fast disintegrating property is obtained by measuring the disintegration time until the fast disintegrating granular ring detergent having a diameter of 18 to 25 mm, preferably 20 mm, is completely decomposed within a temperature of 25 to 35 ° C., preferably 30 ° C. If the disintegration time is within 20 seconds, preferably within 10 seconds, it means fast disintegration.
본 명세서에서 언급하는 '경도'는 제형 유지와 사용감과 관련된 것으로, 속붕해형 과립환 세정제의 붕해시 필요한 힘을 의미한다. 상기 경도는 과립환의 입경 및 입도 분포를 통해 조절이 가능하며, 성형 시 중량 대비 압축에 요구되는 힘의 설정시 적용될 수 있다. 본 발명에서의 경도는 질감 분석기(Texture Analyzer, TA) 이용하여 측정하여 g의 수치로 얻어지며, 500g 이하, 바람직하기로 450g 이하 50g 이상, 더욱 바람직하기로 300g 이하 100g 이상의 수치를 갖는다. 이때 상기 경도 수치가 높을수록 붕해시 속붕해형 과립환 세정제에 요구되는 힘이 높아짐을 의미하며, 그 수치가 낮을수록 적은 힘에서 붕해가 가능함을 의미한다. 그러나 경도가 너무 낮을 경우 환 형태의 유지가 어려우므로 최소한의 수치를 만족시키는 것이 바람직하다.As used herein, the term "hardness" refers to maintaining the formulation and feeling of use, and refers to the strength required for disintegration of the fast disintegrating granular ring detergent. The hardness can be adjusted through the particle size and particle size distribution of the granular ring, it can be applied at the time of setting the force required for compression compared to the weight during molding. Hardness in the present invention is measured by using a texture analyzer (TA) to obtain a numerical value of g, 500g or less, preferably 450g or less 50g or more, more preferably 300g or less 100g or more. In this case, the higher the hardness value, the higher the force required for the disintegrating granule ring detergent during disintegration, and the lower the value, the lower the disintegration is possible at a lower force. However, if the hardness is too low, it is difficult to maintain the ring shape, it is desirable to satisfy the minimum value.
이하 본 발명을 더욱 상세히 설명한다.Hereinafter, the present invention will be described in more detail.
속붕해형 과립환 모발 세정용 조성물Sokbung granules ring hair cleaning composition
속붕해형 과립환 세정제는 세정을 위한 계면활성제, 발포를 위한 발포제 및 붕해를 위한 붕해제를 결합제와 함께 혼합하여 파우더 형태를 압축하여 제조하였으나, 상기 샴푸 내부로 물의 침투가 용이하지 않아 사용이 불편하다는 문제가 있었다. 이에 본 발명에서는 파우더 형태가 아닌 과립 형태로 제조한 후 이를 압축 성형하여 환(pill) 형태로 제조한다. The fast disintegrating granule ring detergent is prepared by compressing the powder form by mixing a surfactant for cleaning, a blowing agent for foaming and a disintegrating agent for disintegration with a binder, but it is inconvenient to use because water is not easily penetrated into the shampoo. There was a problem. Therefore, in the present invention, it is manufactured in the form of granules, not in powder form, followed by compression molding to form a pill form.
과립 형태로 1차 제조 후 이를 뭉쳐 제조된 속붕해형 과립환 세정제는 구조 내에 상기 과립으로 인한 다수의 성근 워터 채널(water channel)을 형성하여 일정 수준 이상의 공극을 유지한다. 상기 공극 및 이로 이루어진 워터 채널로 물이 빠르게 침투 및 이동하여, 상기 물로 인한 과립의 붕괴가 환 제형 전체에 거의 동시에 일어나 붕해 시간을 크게 단축시킬 수 있을뿐만 아니라 경도가 낮아 적은 힘으로도 쉽게 작은 과립으로 붕해되어 상기 붕해 시간을 더욱 단축시킬 수 있다. The fast disintegrating granule ring detergent prepared after the first preparation in the form of granules forms a plurality of sex channel water channels due to the granules in the structure to maintain a certain level of voids. Water quickly penetrates and moves into the voids and the water channels therein, causing the granules to disintegrate due to the water to occur almost simultaneously throughout the ring formulation, greatly reducing disintegration time, as well as low granules, making the granules less easily with less force. Disintegration into may further shorten the disintegration time.
먼저, 과립을 구성하는 조성은 계면활성제, 발포제 및 붕해제를 포함한다. First, the composition constituting the granules includes a surfactant, a blowing agent and a disintegrant.
구체적으로, 본 발명의 계면활성제는 세정력을 부여하는 조성물로서, 물에 녹기 쉬운 친수성 부분과 기름에 녹기 쉬운 소수성(친유성) 부분을 가지고 있는 화합물을 의미한다. 이러한 계면활성제는 음이온성 계면활성제, 양이온성 계면활성제, 양쪽성 계면활성제, 비이온성 계면활성제 또는 이들의 혼합물을 세정제의 용도를 고려하여 선택할 수 있다. 음이온계 계면활성제는 물속에서 해리될 때 음이온이 되는 것이고, 양이온계 계면활성제는 양이온이 되는 것이며, 양쪽성 계면활성제는 분자 내에 음이온 또는 양이온 가능 부위를 모두 가지고 있기 때문에, 용액의 pH에 따라 양이온 또는 음이온이 되며, 비이온 계면활성제는 친수성 부분이 비전해질, 즉 이온화하지 않는 친수성 부분인 것을 의미할 수 있으며 또한, 염(Salt) 상태가 아닌 산(Acid) 상태인 지방산들을 포함할 수 있다.Specifically, the surfactant of the present invention means a compound having a hydrophilic part which is easily dissolved in water and a hydrophobic (lipophilic) part which is easily soluble in oil as a composition for imparting cleaning power. Such surfactants may be selected in consideration of the use of detergents, anionic surfactants, cationic surfactants, amphoteric surfactants, nonionic surfactants or mixtures thereof. Anionic surfactants are anions when dissociated in water, cationic surfactants are cations, and amphoteric surfactants have both anion or cationizable moieties in the molecule. Anionic, nonionic surfactant may mean that the hydrophilic portion is a non-electrolyte, i.e., a hydrophilic portion that does not ionize, and may also include fatty acids in the acid state rather than the salt state.
바람직하게는 기포력이 양호하면서도 세정력이 우수한 음이온 계면활성제로서 C12(라우릴) 내지 C18(스테아릴)의 탄소수를 가지는 알킬 설페이트 또는 여기에 2 내지 5개의 폴리옥시에테르기가 부가된 설페이트를 주로 사용할 수 있으며, 이 외에도 기포력과 세정력이 우수한 음이온 계면활성제가 본 발명의 조성물에 사용될 수 있다. 구체적으로, 기포력과 세정력이 우수한 음이온 계면활성제로서 알리파틱 설포네이트, 아로마틱 설포네이트, 알킬 설페이트, 알킬 에테르 설페이트, 알킬 설포석시네이트, 알킬과 아실 타우레이트, 알킬과 아실 사코시네이트, 설포아세테이트, C8∼C22 알킬 포스페이트, 알킬 포스페이트 에스테르와 알콕시 알킬 포스페이트 에스테르, 아실 락테이트, C8∼C22 모노알킬 석시네이트와 말레이트, 설포아세테이트, 아실 이세티오네이트(acyl isethionate), 폴리카르복실레이트 등이 사용될 수 있다.Preferably, as an anionic surfactant having good foaming power and excellent detergency, an alkyl sulfate having a carbon number of C12 (lauryl) to C18 (stearyl) or a sulfate added with 2 to 5 polyoxyether groups can be mainly used. In addition, anionic surfactants having excellent foaming power and detergency can be used in the composition of the present invention. Specifically, anionic surfactants having excellent foaming power and detergency include aliphatic sulfonates, aromatic sulfonates, alkyl sulfates, alkyl ether sulfates, alkyl sulfosuccinates, alkyl and acyl taurates, alkyl and acyl sacosinates, and sulfoacetates. , C8 to C22 alkyl phosphates, alkyl phosphate esters and alkoxy alkyl phosphate esters, acyl lactates, C8 to C22 monoalkyl succinates and maleates, sulfoacetates, acyl isethionates, polycarboxylates, and the like. Can be.
예컨대, 음이온 계면활성제에 추가하여 양쪽성 계면활성제, 비이온 계면활성제 등을 혼합하여 사용할 수 있으며, 세정용 조성물에 사용되는 것으로 기포력 증진 효과가 있는 것이라면 특별히 한정되지 않는다. 예컨대 양쪽성 계면활성제로는 알킬 베타인, 알킬 설테인, 알킬 아미도프로필 베타인, 알킬 아미도프로필 하이드록시 설테인, 알킬 암포아세테이트, 알킬 다이암포아세테이트(alkyl diamphoacetate) 등을 사용할 수 있다. 또한, 사용 가능한 비이온 계면활성제로는 예컨대 알킬 글루코스 아마이드, 알킬 글루코스 에스테르, 폴리옥시에틸렌 에스테르, 지방산 알킬아마이드, 알킬 아민 옥사이드, 알킬 폴리글루코사이드, 폴리옥시에틸렌 에스테르 지방산 등을 사용할 수 있다.For example, an amphoteric surfactant, a nonionic surfactant, etc. can be mixed and used in addition to an anionic surfactant, and it is used in a cleaning composition, If it has a bubble enhancement effect, it will not specifically limit. For example, as the amphoteric surfactant, alkyl betaine, alkyl sulfate, alkyl amidopropyl betaine, alkyl amidopropyl hydroxy sulfate, alkyl ampoacetate, alkyl diamphoacetate and the like can be used. In addition, usable nonionic surfactants include, for example, alkyl glucose amides, alkyl glucose esters, polyoxyethylene esters, fatty acid alkylamides, alkyl amine oxides, alkyl polyglucosides, polyoxyethylene ester fatty acids, and the like.
상기 계면활성제는 속붕해형 과립환 세정제 총 중량에 대하여 5 내지 55 중량%, 바람직하기로 7 내지 30 중량%로 함유되는 것이 세정 효과를 확보하는데 바람직하다. 그 함량이 상기 범위 미만이면 충분한 세정 효과를 확보할 수 없고, 이와 반대로 상기 범위를 초과할 경우 과도한 세정력으로 인하여 피부에 유해할 수 있으며, 눅진한 사용감을 주고, 피부 또는 모발에 잔여할 가능성이 높다.The surfactant is preferably contained in 5 to 55% by weight, preferably 7 to 30% by weight based on the total weight of the fast disintegrating granular ring detergent to ensure a cleaning effect. If the content is less than the above range, a sufficient cleaning effect cannot be secured. On the contrary, if the content exceeds the above range, it may be harmful to the skin due to excessive cleansing power, giving a damp feeling of use, and likely remaining on the skin or hair. .
본 발명에 적용되는 발포제는 무기탄산염과 약산이 반응하여 이산화탄소(CO2)를 발생시키는 원리로, 속붕해형 과립환 세정제가 수중에서 신속하게 발포하며 붕해될 수 있도록 해준다. 무기탄산염으로는 중탄산나트륨(NaHCO3), 중탄산칼륨(KHCO3), 중탄산칼슘(Ca(HCO3)2), 탄산나트륨(Na2CO3), 탄산칼륨(K2CO3), 탄산칼슘(CaCO3) 또는 이들의 혼합물이 가능하며, 바람직하게는 중탄산나트륨(NaHCO3)을 적용한다. 또한, 약산은 구연산(Citric acid), 주석산(Tartaric acid), 인산(Phosphoric acid), 아세트산(Acetic acid), 말레산(Maleic acid), 푸마르산(Fumaric acid) 중 선택되는 1종 이상이 가능하나, 본 발명에서 이를 제한하는 것은 아니지만, 바람직하게는 구연산을 적용한다.The blowing agent applied to the present invention is a principle in which the inorganic carbonate and the weak acid react to generate carbon dioxide (CO 2 ), so that the fast disintegrating granule ring detergent can be rapidly foamed and disintegrated in water. Inorganic carbonates include sodium bicarbonate (NaHCO 3 ), potassium bicarbonate (KHCO 3 ), calcium bicarbonate (Ca (HCO 3 ) 2 ), sodium carbonate (Na 2 CO 3 ), potassium carbonate (K 2 CO 3 ), calcium carbonate (CaCO 3 ) or mixtures thereof, preferably sodium bicarbonate (NaHCO 3 ) is applied. In addition, the weak acid may be at least one selected from citric acid, tartaric acid, phosphoric acid, acetic acid, maleic acid, and fumaric acid. Although not limiting in the present invention, citric acid is preferably applied.
상기 발포제는 속붕해형 과립환 세정제 총 중량에 10 내지 50 중량%, 바람직하기로 15 내지 45 중량%로 함유되며, 이때 무기탄산염 및 약산은 각각 5 내지 45 중량%로 사용하고, 더욱 바람직하기로 무기탄산염: 약산은 1:0.1 내지 1:0.6의 중량비로 사용하는 것이 이산화탄소를 발생시켜 기포력을 확보하기에 바람직하다. 만약 발포제의 함량이 상기 범위 미만이면 충분한 기포 형성이 어려워 사용감이 저하되고, 이와 반대로 상기 범위를 초과할 경우 과도한 기포 형성으로 인해 이 또한 저하를 가져온다.The blowing agent is contained in 10 to 50% by weight, preferably 15 to 45% by weight of the total weight of the disintegrated granule ring detergent, wherein inorganic carbonate and weak acid are used in 5 to 45% by weight, respectively, more preferably Inorganic carbonate: It is preferable to use a weak acid in a weight ratio of 1: 0.1 to 1: 0.6 in order to generate carbon dioxide and to secure a foaming force. If the content of the blowing agent is less than the above range, sufficient bubble formation is difficult and the feeling of use decreases. On the contrary, if the above foaming range is exceeded, this also causes a decrease due to excessive bubble formation.
본 발명에 적용되는 붕해제는 제약분야에서 일반적으로 사용되는 것으로 수분에 의해 부피가 팽창된다. 상기 붕해제는 전분류(Starches), 미결정 셀룰로오스(Microcrystalline cellulose), 크로스포비돈(Crospovidone), 저치환 하이드록시프로필셀룰로오스(Low-substituted hydroxypropyl cellulose), 크로스카르멜로오스(Croscarmellose) 중 선택되는 1종 이상이 가능하나 이에 한정되지 않는다.Disintegrants applied in the present invention are generally used in the pharmaceutical field and are expanded in volume by moisture. The disintegrant is at least one selected from starches, microcrystalline cellulose, crospovidone, low-substituted hydroxypropyl cellulose and croscarmellose. This is possible but not limited to.
상기 붕해제는 속붕해형 과립환 세정제 총 중량에 1 내지 25 중량%, 바람직하기로 5 내지 20 중량%로 사용한다. 만약 그 함량이 상기 범위 미만이면 과립환의 붕해 속도가 느리고, 이와 반대로 상기 범위를 초과하면 붕해 속도 조절이 용이하지 않다.The disintegrant is used in an amount of 1 to 25% by weight, preferably 5 to 20% by weight, based on the total weight of the fast disintegrating granular ring detergent. If the content is less than the above range, the disintegration rate of the granule ring is slow, and if the content exceeds the above range, it is not easy to control the disintegration rate.
상기 계면활성제, 발포제 및 붕해제를 포함하는 과립은 후속에서 설명하는 약제학적 제조법인 습식 과립화 공정을 이용하여 제조되며, 다양한 형태로 제조된다.Granules comprising the surfactant, blowing agent and disintegrant are prepared using a wet granulation process, which is the pharmaceutical preparation described below, and is prepared in various forms.
바람직하기로, 상기 과립은 구형, 또는 실린더형(또는 펠렛형)일 수 있으며, 워터 채널 형성이나 기공 특성 등을 고려할 때 실린더형이 보다 유리하다. 이러한 과립은 구형의 경우 입경이 0.1 내지 3.0mm, 바람직하기로 0.5 내지 1.5mm를 갖는다. 또한, 실린더형의 경우 입경이 0.1 내지 3.0mm, 바람직하기로 0.5 내지 1.5mm이고, 길이가 0.2 내지 5.0mm, 바람직하기로 0.7 내지 3.0mm를 갖는다. 만약 과립의 입경 및 길이가 상기 범위 미만이면 과립화 공정에서 유동성이 저하되어 과립 간 뭉침 현상이 발생하고, 이와 반대로 상기 범위를 초과하면 물과 닿는 표면적이 줄어들어 완전히 용해되기까지 시간이 걸릴 뿐만 아니라 크리미한 기포력이 저하되기 때문에 바람직하지 못하다. 이때 과립의 크기 및 형태는 습식 과립화 공정 중 과립을 만들기 위해 체(sieve)를 통해 압출시키는 제립 공정에서 조절이 가능하다. Preferably, the granules may be spherical or cylindrical (or pelletized), and cylindrical is more advantageous when considering water channel formation or pore characteristics. These granules have a particle diameter of 0.1 to 3.0 mm, preferably 0.5 to 1.5 mm in the case of spheres. In addition, the cylindrical type has a particle diameter of 0.1 to 3.0 mm, preferably 0.5 to 1.5 mm, a length of 0.2 to 5.0 mm, preferably 0.7 to 3.0 mm. If the particle size and length of the granules are less than the above range, fluidity decreases in the granulation process, and agglomeration between granules occurs. On the contrary, if the particle size and length exceed the above range, the surface area in contact with water decreases and it takes time to completely dissolve. It is not preferable because one bubble force falls. In this case, the size and shape of the granules can be controlled in the granulation process of extruding through a sieve to make granules during the wet granulation process.
이러한 과립은 결합제에 의해 결합되어 속붕해형 과립환 세정제를 형성한다. These granules are bound by a binder to form a fast disintegrating granule ring detergent.
결합제는 과립들 간의 부착을 도와주고 압축 후 제형 상태를 유지하기 위해 사용한다. 사용 가능한 결합제로는 글리세린, 실리콘오일류, 폴리올류 및 이들의 조합으로서, 1,3-부틸렌글리콜, 디프로필렌글리콜, 프로필렌글리콜, 폴리에틸렌글리콜 및 그 외 액상의 폴리올류 중 선택되는 1종 이상을 사용하는 것이 가능할 수 있다.The binder is used to aid adhesion between the granules and to maintain the formulation after compression. As the binder which can be used, one or more selected from 1,3-butylene glycol, dipropylene glycol, propylene glycol, polyethylene glycol and other liquid polyols may be used as glycerin, silicone oils, polyols and combinations thereof. It may be possible to.
상기 결합제는 속붕해형 과립환 세정제의 과립환에 의해 일정 수준의 기공 및 워터 채널을 유지하되, 상기 기공 및 워터 채널이 최종 성형 공정에서 유지할 수 있도록 그 함량을 한정한다. 바람직하기로, 상기 결합제는 속붕해형 과립환 세정제 총 중량에 대하여 1 내지 30 중량%, 바람직하기로 5 내지 20 중량%로 사용한다. 만약 그 함량이 상기 범위 미만이면 과립 간의 결합 또는 부착이 어려와 환으로 성형 공정 시 붕괴의 위험이 있으며, 이와 반대로 상기 범위보다 과량 사용할 경우 기공 및 워터 채널이 감소하여 속붕해 특성을 확보할 수 없으며 눅진한 사용감을 갖는다. The binder maintains a certain level of pores and water channels by the granule rings of the fast disintegrating granule ring cleaner, and limits its content so that the pores and water channels can be maintained in the final molding process. Preferably, the binder is used in an amount of 1 to 30% by weight, preferably 5 to 20% by weight, based on the total weight of the fast disintegrating granular ring detergent. If the content is less than the above range, there is a risk of collapse during the molding process due to difficulty in bonding or adhesion between granules. On the contrary, when used in excess of the above range, pores and water channels decrease, so that fast disintegration characteristics cannot be obtained. It has a loose feel.
또한, 본 발명의 속붕해형 과립환 세정제는 필요에 따라 추가적으로 상기한 바와 같은 세정제 조성물의 점도를 조절하기 위한 점증제나 기포를 안정화하기 위한 기포 안정제와 같은 첨가제가 더 포함될 수도 있다. 여기서, 점증제라 함은 물 또는 유기용매에 녹아 고점도의 점액질을 형성하는 것으로, 세정제의 점도를 높이기 위한 것으로, 벤토나이트, 클레이, 실리카, 아크릴계 고분자, 비닐계 고분자, 셀룰로오스 및 검 등을 사용할 수 있으며, 기포 안정제로는 라우르산을 사용할 수 있다.In addition, the fast disintegrating granule ring cleaning agent of the present invention may further include an additive such as a thickener for adjusting the viscosity of the cleaning composition as described above or a bubble stabilizer for stabilizing the bubbles as necessary. Here, the thickener is to form a high viscosity mucus by dissolving in water or an organic solvent, to increase the viscosity of the detergent, bentonite, clay, silica, acrylic polymer, vinyl polymer, cellulose and gum can be used, Lauric acid can be used as a bubble stabilizer.
본 발명의 속붕해형 과립환 세정제는 모발용 세정제인 경우, 모발에 윤기, 부드러움, 정전기방지 및 탄력을 부여하는 모발 컨디셔닝제를 추가적으로 포함할 수 있다. 모발 컨디셔닝제는 글리세린, 양이온 폴리머인 구아코트(Guarquat), 탄소수 C10∼C22 알킬트리메틸암모늄클로라이드(Alkyl trimethyl ammonium chloride, ATAC), C10∼C22 디알킬메틸암모늄클로라이드(Dialkylmethylammonium Chloride, DDAC), 베헤닐트리메틸암모늄클로라이드(Behenyltrimethylammonium Chloride, BTAC), 스테아릴트리메틸암모늄클로라이드(Stearyltrimethylammonium Chloride,STAC), 트리세틸메틸암모늄클로라이드(Tricetylmethylammonium Chloride, TCMAC)를 단독으로 또는 조합하여 사용할 수 있다. 기존 액상의 모발용 세정제는 조성물이 용해되어 있기 때문에 원료 자체의 감촉은 고려하지 않아도 되지만, 파우더 원료를 과립화하여 고형화하는 본 발명의 속붕해형 과립환 세정제의 경우 파우더 특유의 뻣뻣한 사용감을 가질 수 있으므로, 상기 모발 컨디셔닝제를 추가 함유함으로써 사용감을 개선할 수 있다.When the fast disintegrating granule ring cleaner of the present invention is a hair cleaner, it may further include a hair conditioning agent that imparts shine, softness, antistatic and elasticity to the hair. Hair Conditioning Agents Glycerin, Guarquat, Cationic Polymer, Alkyl trimethyl ammonium chloride (ATAC), C10-C22 Dialkylmethylammonium Chloride (DDAC), Behenyltrimethyl Ammonium chloride (Behenyltrimethylammonium Chloride, BTAC), Stearyltrimethylammonium Chloride (STAC), Tricetylmethylammonium Chloride (TCMAC) may be used alone or in combination. Existing liquid hair cleanser does not have to consider the texture of the raw material itself because the composition is dissolved, but in the case of the fast disintegrating granule ring cleaner of the present invention to granulate and solidify the powder raw material may have a stiff feeling unique to the powder By further containing the hair conditioner, the usability can be improved.
또한, 본 발명의 속붕해형 과립환 세정제는 적당한 부피감을 부여하여 충진하며 몰드 성형하기 위하여, 세정제 본연의 세정력과 기포력을 저하시키지 않는 성분으로서, 유당, 만니톨, 전분, 솔비톨, 결정성 셀룰로오스, 폴리피롤리돈, 하이드록시메틸셀룰로오스 중에서 선택되는 1종 이상의 필러를 사용하는 것이 가능하다.In addition, the fast disintegrating granular ring detergent of the present invention is a component that does not lower the cleaning power and foaming power of the cleaning agent in order to provide the appropriate volume feeling and to fill the mold, lactose, mannitol, starch, sorbitol, crystalline cellulose, It is possible to use at least one filler selected from polypyrrolidone and hydroxymethyl cellulose.
이외에도 본 발명의 속붕해형 과립환 세정제는 당업계에서 통상적으로 사용되는 첨가제를 포함할 수 있으며, 예를 들어 방부제, 향료, pH 조절제, 점도 조절제, 보습제, 및 살균제 등에서 선택된 하나 이상의 첨가제를 포함할 수 있다. 이와 같은 첨가제들은 본 발명에 따른 속붕해형 과립환 세정제 전체 중량 기준으로 각 첨가제의 종류에 따라, 예를 들어 0.001∼10 중량% 범위 내에서 포함될 수 있다.In addition, the fast disintegrating granule ring cleaner of the present invention may include additives commonly used in the art, and may include, for example, one or more additives selected from preservatives, flavoring agents, pH adjusting agents, viscosity adjusting agents, humectants, and fungicides. Can be. Such additives may be included, for example, within the range of 0.001 to 10% by weight, depending on the type of each additive based on the total weight of the fast disintegrating granular ring cleaner according to the present invention.
전술한 바의 조성을 갖는 본 발명에 따른 속붕해형 과립환 세정제는 물과 접촉시 상기 과립포환의 내/외부의 빠른 물 침투를 통해 속붕해가 일어나고, 경도가 낮아 적은 힘으로도 쉽게 과립으로 붕해된 후 크리미한 거품을 발생시킨다. 이러한 속붕해형 과립환 세정제는 1회 분량으로 분할 성형하며, 바람직하기로 1 내지 5g, 더욱 바람직하기로 2 내지 3g을 1회 분량으로 한다. 이 경우 25 내지 35℃의 물과 접촉 후 적은 힘 가하고 작은 과립이 빠르게 물과 반응하여 거품을 형성하고 5 내지 15초, 바람직하기로 10초 이내의 붕해 시간을 갖는다.The fast disintegrating granule ring cleaner according to the present invention having the composition as described above is rapidly disintegrated through rapid water penetration into and out of the granular shell when contacted with water, and the hardness is low so that disintegration into granules is easy even with low force. After the creamy cream is generated. Such fast disintegrating granule ring cleaning agent is divided and molded into one portion, preferably 1 to 5g, more preferably 2 to 3g in one portion. In this case, after contact with water at 25 to 35 ° C., little force is applied and the small granules rapidly react with water to form bubbles and have a disintegration time of 5 to 15 seconds, preferably 10 seconds or less.
상기 1회 분량은 머리 길이나 숱 등을 고려하여 상기 범위보다 크거나 작게 제작할 수 있다. 일례로, 구형의 환 제형으로 속붕해형 과립환 세정제를 제조할 경우 직경을 18 내지 25 파이(Φ)로 제조가 가능하며, 짧은 머리의 경우 2 내지 3g을 사용하여 20 내지 22 파이 직경을 갖도록 제조한다. 이때 1 파이(Φ)는 1mm의 직경을 의미하며, 상기 1회분 속붕해형 과립환 세정제는 18 내지 25mm의 직경을 가질 수 있음을 의미한다.The single dose may be made larger or smaller than the above range in consideration of hair length or thinning. For example, when preparing a fast disintegrating granule ring detergent in the form of a spherical ring, it is possible to produce a diameter of 18 to 25 pies (Φ), and for short hairs to have a diameter of 20 to 22 pies using 2 to 3 g. Manufacture. At this time, 1 phi (Φ) means a diameter of 1mm, it means that the batch disintegrating granules detergent may have a diameter of 18 to 25mm.
또한, 본 발명의 속붕해형 과립환 세정제는 그 용도나 형상의 제한은 없으며 약제학적 습식 과립법으로 제조 가능한 형태면 어느 형태는 가능하다. 일례로, 상기 속붕해형 과립환 세정제는 구형, 편구형, 반구형, 실린더형, 럭비볼형, 원추형, 원통형, 다각형, 사다리꼴, 각주형, 직육면체 등 사용자에게 만족감 및 우수한 사용감을 수 있는 것이면 어떤 형태는 한정하지 않는다. 일례로, 본 발명의 실시예에서는 구형으로 제작하였다. Further, the fast disintegrating granule ring cleaning agent of the present invention is not limited in its use or shape, and any form can be used as long as it can be produced by the pharmaceutical wet granulation method. For example, the fast disintegrating granule ring cleaner is spherical, spherical, hemispherical, cylindrical, rugby ball type, conical, cylindrical, polygonal, trapezoidal, square shape, cuboid, etc., if any form can be satisfied with the user and excellent feeling It is not limited. For example, in the embodiment of the present invention was produced in a spherical shape.
더불어, 제형의 습기 안정화를 위하여 상기 속붕해형 과립환 세정제는 내수성을 가지는 오일이나, 활택제 또는 실리카와 같은 물질로 제형의 피막을 코팅할 수 있다. 또한, 제품의 습기 안정화와 포장 내 경도를 유지하기 위한 포장재를 선택하는 것이 바람직하다. 예컨대, 다수의 제형이 포장되는 멀티 포켓형 포장재, 원터치로 1개의 제형이 토출되는 디스펜서(Dispenser) 포장재 또는 필 오프(Peel off) 타입의 플라스틱 포장재(예, Blister Package) 등이 적용 가능할 수 있다.In addition, the fast disintegrating granule ring detergent may be coated with a coating of the formulation with a material such as an oil having a water resistance, or a lubricant or silica to stabilize moisture of the formulation. It is also desirable to select a packaging material to maintain moisture stabilization and hardness in the packaging of the product. For example, a multi-pocket type packaging material in which a plurality of dosage forms are packaged, a dispenser packaging material in which one dosage form is discharged in one touch, or a peel off type plastic packaging material (eg, Blister Package) may be applicable.
속붕해형 과립환 세정제 모발 세정용 조성물의Sokbung granules ring cleaner of the hair cleaning composition 제조방법Manufacturing method
상기 제시한 속붕해형 과립환 세정제는 과립이 결합제에 의해 결합된 형태를 가지며, 이는 특히 약제학적 습식 과립법을 통해 제조한다.The fast disintegrating granule ring cleaner presented above has a form in which granules are bound by a binder, which is prepared in particular by pharmaceutical wet granulation.
습식 과립 공정은 원료 성분의 칭량 및 혼합 공정, 연합 공정, 조립 공정, 건조 공정 및 정립 공정 순으로 이루어진다. 이러한 습식 과립 공정은 분체의 유동성을 확보하고, 원료 물질의 밀도를 증가시키며, 압축성을 향상시키는 이점이 있다. 본 발명에서는 상기 습식 과립 공정의 원료로 모발 세정에 사용하는 전술한 바의 계면활성제, 발포제, 붕해제, 및 기타 첨가제를 사용하여 과립을 먼저 제조하고, 상기 과립을 조립을 위해 결합제를 사용함으로써 1회 분량의 속붕해형 과립환 세정제를 제조한다.The wet granulation process consists of the weighing and mixing of the raw material components, the assembling process, the assembly process, the drying process and the sizing process. This wet granulation process has the advantage of ensuring the fluidity of the powder, increase the density of the raw material, and improve the compressibility. In the present invention, by using the above-described surfactant, blowing agent, disintegrant, and other additives used for washing hair as a raw material of the wet granulation process, the granules are first prepared, and the granules are prepared by using a binder for granulation. An amount of fast disintegrating granules ring detergent is prepared.
특히, 본 발명의 속붕해형 과립환 세정제는 크게 과립화 단계와 성형 단계로 나누며, 물과 접촉시 붕해가 일어나므로, 이들 공정은 물의 사용을 배제하는 무수 제형으로 제조한다. In particular, the fast disintegrating granule ring cleaning agent of the present invention is divided into granulation step and molding step, and since the disintegration occurs in contact with water, these processes are prepared in anhydrous formulations excluding the use of water.
구체적으로, 속붕해형 과립환 세정제는 Specifically, the fast disintegrating granule ring cleaner
(i) 계면활성제, 발포제, 및 붕해제를 혼합하여 혼합 분말을 제조하는 단계;(i) mixing a surfactant, a blowing agent, and a disintegrant to prepare a mixed powder;
(ii) 상기 혼합 분말에 습윤제를 첨가하여 반죽을 수행하는 단계;(ii) adding a humectant to the mixed powder to perform a dough;
(iii) 얻어진 반죽물을 제립 후 건조하여 과립을 제조하는 단계;(iii) granulating and drying the obtained dough to prepare granules;
(iv) 상기 과립을 결합제와 혼합하는 단계; 및(iv) mixing the granules with a binder; And
(v) 얻어진 혼합물을 몰드를 이용하여 압축 성형하는 단계를 거쳐 제조한다.(v) The resulting mixture is prepared by compression molding using a mold.
이하 상기 제조 방법을 도면을 참조하여 각 단계별로 상세히 설명한다. 도 2는 본 발명에 따른 속붕해형 과립환 세정제의 제조 순서를 보여주는 순서도이고, 도 3은 이미지이다.Hereinafter, the manufacturing method will be described in detail with reference to the drawings. Figure 2 is a flow chart showing the manufacturing process of the fast disintegrating granules ring cleaning agent according to the present invention, Figure 3 is an image.
(i) 혼합 분말 제조 단계(i) Mixed Powder Manufacturing Step
먼저, 혼합기에 계면활성제, 발포제, 및 붕해제를 첨가한 후 균일하게 혼합하여 혼합물을 제조한다(도 3(a) 참조).First, a surfactant, a blowing agent, and a disintegrant are added to the mixer, and then mixed uniformly to prepare a mixture (see FIG. 3 (a)).
이때 각 조성은 전술한 바의 조성 및 함량 범위 내에서 사용한다. At this time, each composition is used within the composition and content range of the bar described above.
(ii) 반죽 단계(ii) kneading step
다음으로, 상기 (i) 단계에서 얻어진 혼합물에 습윤제를 첨가한 후 반죽 공정을 통해 반죽을 제조한다(도 3(b) 참조).Next, after the wetting agent is added to the mixture obtained in step (i), a dough is prepared through a kneading process (see FIG. 3 (b)).
이때 사용하는 습윤제에 의해 계면활성제, 발포제 및 붕해제의 물리적인 결합을 위해 사용한다. 특히, 계면활성제, 발포제 및 붕해제가 물과 만나면 곧바로 반응(붕해)이 일어나는데, 본 발명에서는 상기 원료를 고루 혼합하고 이를 결합시키기 위한 액상 물질로 물을 배제한 무수 결합액을 사용한다. 상기 무수 결합액으로는 독성이 상대적으로 낮으며 휘발성이 있는 용매인 에탄올, 메탄올 및 아세톤 중 선택되는 1종 이상이 가능하며, 바람직하기로는 에탄올을 사용한다.At this time, it is used for the physical bonding of the surfactant, the blowing agent and the disintegrating agent by the humectant used. In particular, when a surfactant, a blowing agent and a disintegrant meet water, a reaction (disintegration) takes place immediately. In the present invention, an anhydrous binder liquid without water is used as a liquid material for evenly mixing the raw materials and bonding them. As the anhydrous binder solution, at least one selected from ethanol, methanol, and acetone, which are relatively low in toxicity and volatile, may be used. Preferably, ethanol is used.
상기 습윤제는 과립 조성의 총 합 100 중량부 대비 1 내지 50 중량부, 바람직하기로 5 내지 25 중량부로 사용한다. 만약, 그 함량이 상기 범위 미만이면 원료의 결합이 충분치 못하여 과립 제조시 형태가 부서질 우려가 있고, 이와 반대로 상기 범위를 초과하여 과도하게 사용할 경우에도 과립 제조가 불가능하다. The humectant is used in an amount of 1 to 50 parts by weight, preferably 5 to 25 parts by weight, based on 100 parts by weight of the total composition of the granules. If the content is less than the above range, there is a possibility that the binding of the raw materials is insufficient, and the shape may be broken during the preparation of the granules.
이러한 반죽 공정은 공지의 반죽기를 사용할 수 있으며, 일례로 니더(Kneader) 또는 포니믹서(Ponymixer)가 사용될 수 있다.Such a kneading process may use a known kneader, and for example, a kneader or ponymixer may be used.
(iii) 과립 제조 단계(iii) granule manufacturing step
다음으로, 상기 (ii) 단계에서 반죽된 반죽을 스크린에 통과시키는 압출하는 제립 공정 및 건조 공정을 수행하여 과립을 제조한다(도 3(c) 및 (d) 참조).Next, granules are prepared by performing an extrusion granulation process and a drying process of passing the dough kneaded in step (ii) to a screen (see FIGS. 3 (c) and (d)).
이때 스크린은 통상 0.5 내지 1.5 메쉬의 체(sieve)가 사용되며, 그 크기에 따라 최종 얻어지는 과립의 입경이 달라진다.In this case, a sieve of 0.5 to 1.5 mesh is generally used, and the particle size of the final granules varies depending on the size.
건조는 상기 과립 내 습윤제가 충분히 제거될 수 있는 온도로 수행하며, 바람직하기로 25 내지 80℃에서 0.5 내지 5시간 동안 수행한다. 이러한 온도 및 시간은 습윤제의 제거를 위해 이 분야의 통상의 지식을 가진 자에 의해 변경 가능하다.Drying is carried out at a temperature at which the wetting agent in the granules can be sufficiently removed, preferably at 25 to 80 ° C. for 0.5 to 5 hours. Such temperatures and times can be altered by one of ordinary skill in the art for the removal of humectants.
본 과립 제조를 위한 과립기는 약제학 분야에서 통상적으로 사용하는 과립기가 사용될 수 있으며, 본 발명에서 특별히 한정하지 않는다.Granulator for producing the granules may be used granulators commonly used in the pharmaceutical field, it is not particularly limited in the present invention.
(iv) 과립 및 결합제 혼합 단계(iv) mixing granules and binders
다음으로, 상기 (iii) 단계에서 얻어진 과립에 결합제를 첨가하여 균일하게 혼합한다(도 3(e) 참조).Next, the binder is added to the granules obtained in step (iii) and mixed uniformly (see FIG. 3 (e)).
상기 결합제는 전술한 바의 원료를 칭량하여 사용한다. 또한, 상기 결합제는 한꺼번에 투여하거나 수회 분할 투여할 수 있다.The binder is used by weighing the raw material as described above. In addition, the binder may be administered at once or divided doses.
이때 혼합기는 본 발명에서 특별히 한정하지 않으며, 고속혼합기, 더블 콘 믹서, 콘 블렌더, 리본 블렌더, 셔블 믹서, 퍼그믹서-헨셸믹서, 브라벤더, 2축 혼련기 등을 사용할 수 있다. In this case, the mixer is not particularly limited, and a high speed mixer, a double cone mixer, a cone blender, a ribbon blender, a shovel mixer, a pug mixer-Henschel mixer, a brabender, a biaxial mixer, or the like can be used.
(v) 압축 성형 단계(v) compression molding step
다음으로, 상기 (iv) 단계에서 얻어진 혼합물을 몰드를 이용하여 압축 성형하여 환(pill) 제형의 속붕해형 과립환 세정제를 제조한다(도 3(f) 및 (g) 참조).Next, the mixture obtained in step (iv) is compression molded using a mold to prepare a fast disintegrating granule ring detergent of a pill formulation (see FIGS. 3 (f) and (g)).
상기 압축 성형(Compression Molding)은 몰드 내에 혼합물을 주입한 후 압력을 인가하여 수행한다. 이때 인가되는 압력은 혼합물이 충분히 결합되어 소정 형태로 성형될 수 있는 수준이 가능하며, 몰드의 크기에 따라 달라진다. 인가되는 압력이 부족할 경우 속붕해형 과립환 세정제의 사용 또는 보관시 손상 또는 깨짐이 발생하므로 적절히 수행한다.The compression molding is performed by applying a pressure after injecting a mixture into a mold. At this time, the applied pressure may be a level at which the mixture is sufficiently combined to be formed into a predetermined shape, and depends on the size of the mold. If the applied pressure is insufficient, so that the damage or cracking occurs when using or storing the fast disintegrating granular ring detergent is performed properly.
이때 몰드는 도 1에 나타낸 바와 같이, 환(Pill) 제형으로 성형이 가능한 것이면 어느 것이든 사용 가능하다.At this time, as shown in Figure 1, as long as the mold (Pill) can be molded in any form can be used.
전술한 바의 단계를 거쳐 제조된 속붕해형 과립환 세정제는 약제학적 습식 과립 공정을 응용하여 제조된 것으로, 종래와 같이 파우더끼리 결합된 형태가 아닌 과립끼리 뭉쳐있는 형태로서, 표면 및 내부에 랜덤한 기공이 형성되고, 워터 채널이 형성되어 물과 접촉시 적은 힘으로도 쉽게 작은 과립으로 부서지며, 이들 작은 과립이 빠르게 붕해되어 크리미한 거품을 형성한다. The fast disintegrating granule ring cleaner prepared by the above-described steps is prepared by applying a pharmaceutical wet granulation process, and is a form in which granules are aggregated together rather than powders in a conventional manner. One pore is formed, and a water channel is formed, which breaks easily into small granules with little force upon contact with water, and these small granules disintegrate quickly to form creamy bubbles.
이에 사용자로 하여금 거품 형성이 용이하여 편의성과 함께 손에서의 풀림성, 감촉 등이 우수한 이점이 있다.This allows the user to easily form the foam has the advantage of excellent ease of loosening, texture, etc. in the hand.
이하, 본 발명을 실시예에 의해 보다 상세히 설명하고자 한다. 하지만, 본 발명은 하기 실시예에 의해 한정되는 것은 아니며, 본 발명의 기술 사상 범위 내에서 여러 가지 변형 또는 수정할 수 있음은 이 분야에 통상의 지식을 가진 자에게는 명백한 것이다. Hereinafter, the present invention will be described in more detail with reference to Examples. However, the present invention is not limited by the following examples, and it can be apparent to those skilled in the art that various changes or modifications can be made within the technical idea of the present invention.
[실시예]EXAMPLE
실시예 1Example 1
하기 표 1의 조성으로 속붕해형 과립환을 제조하였다. 이때 각 공정은 도 3에 나타낸 이미지를 따른다. Sokbung granules were prepared in the composition of Table 1 below. At this time, each process follows the image shown in FIG.
1. 과립화 단계1. Granulation step
소듐라우릴설페이트(SLS), 구연산, 중탄산나트륨, 전분, 향, STAC 80(I), 유당, 구아코트를 균일하게 혼합한 후, 에탄올을 첨가하여 반죽형태의 혼합물을 1.0mm의 체에 일정 크기로 압출시킨 후 건조하여 상기 에탄올이 제거된 건조 과립체를 제조하였다.After homogeneously mixing sodium lauryl sulfate (SLS), citric acid, sodium bicarbonate, starch, fragrance, STAC 80 (I), lactose and guar coat, add ethanol to mix the dough-type mixture into a 1.0 mm sieve. Extruded into and then dried to prepare a dry granules from which the ethanol was removed.
2. 성형 단계2. Molding Step
상기 제조된 건조 과립체에 글리세린과 실리콘 오일을 첨가하여 혼합한 후, 구 형상의 몰드에 혼합물을 압착하여 성형된 속붕해형 과립환 세정제(직경: 20 파이)를 제조하였다.Glycerin and silicone oil were added to the dry granules prepared above, followed by mixing. Then, the mixture was pressed into a spherical mold to prepare a fast disintegrating granule ring cleaner (diameter: 20 pies).
비교예 1Comparative Example 1
소듐라우릴설페이트(SLS), 구연산, 중탄산나트륨, 전분, 향, STAC 80(I), 유당, 구아코트를 균일하게 혼합한 후, 글리세린과 실리콘 오일을 첨가하여, 구형 몰드에 혼합물을 압착 성형된 파우더환 세정제를 제조하였다.After homogeneously mixing sodium lauryl sulfate (SLS), citric acid, sodium bicarbonate, starch, fragrance, STAC 80 (I), lactose and guar coat, glycerin and silicone oil were added to compress the mixture into a spherical mold. Powder ring detergent was prepared.
조성(중량%)Composition (% by weight) 실시예 1Example 1 비교예 1Comparative Example 1
소듐라우릴설페이트(SLS)Sodium Lauryl Sulfate (SLS) 13.413.4 1515
구연산Citric acid 6.356.35 77
중탄산나트륨Sodium bicarbonate 22.722.7 2525
전분Starch 6.976.97 7.57.5
향incense 0.130.13 0.150.15
STAC 80(I)STAC 80 (I) 0.450.45 0.50.5
유당Lactose 3131 33.8533.85
구아코트Guarco 2.32.3 2.52.5
글리세린glycerin 6.86.8 7.57.5
실리콘 오일Silicone oil 0.90.9 1One
에탄올ethanol 9.09.0 --
총합total 100100 100100
실험예 1Experimental Example 1
과립으로 압축성형된 속붕해형 과립환 세정제(실시예 1)와 파우더로 압착 성형된 파우더환 세정제(비교예 1)를 평균 붕해 경도, 수중 붕해 성상, 수중 붕해 시간에 대하여 테스트한 결과를 하기 표 2에 나타내었다. The results of testing the average disintegration hardness, the disintegration properties in water, and the disintegration time in water of the fast disintegrating granule ring cleaner (Example 1) and the compression-molded powder ring cleaner (Comparative Example 1) powdered into granules 2 is shown.
이때 평균 붕해 경도는 물성 측정기(Texture Analyzer)로 측정하되, Test speed는 2.00mm/sec, Target mode는 Distance: 5.0mm, Trigger type은 Auto(Force): 0.049N로 설정하였다. 환 붕해 시 필요한 힘을 질량(g)으로 환산하였으며, 낙하 거리에 따른 환산된 힘을 도 4의 데이터에 표시하였다. 이때 측정된 경도 수치가 낮은 것은 적은 힘으로도 쉽게 붕괴가 가능함을 의미한다. 또한, 붕해 성상 및 붕해 시간은 30℃의 온도(수중 내)에서 측정하였다.At this time, the average disintegration hardness was measured by a physical property analyzer, but the test speed was set to 2.00mm / sec, the target mode was set to Distance: 5.0mm, and the trigger type was set to Auto (Force): 0.049N. The force required for ring disintegration was converted into mass (g), and the converted force according to the drop distance was shown in the data of FIG. 4. The low hardness value measured here means that it can be easily collapsed with little force. In addition, disintegration property and disintegration time were measured at the temperature (in water) of 30 degreeC.
테스트 항목test item 실시예 1Example 1 비교예 1Comparative Example 1
평균 붕해 경도(g)Average Disintegration Hardness (g) 375375 32503250
붕해 성상Disintegration 과립으로 쉽게 붕해Disintegrates easily into granules 잘 풀리지 않는 덩어리로 붕해Disintegrate into lumps
붕해 시간Disintegration time 10초10 sec 20분20 minutes
상기 표 2 및 도 4에 나타난 바와 같이, 속붕해형 과립환 세정제(실시예 1)의 평균 붕해 경도는 375g으로 파우더환 세정제(비교예 1)의 붕해 경도 3250g에 비해 약 1/10 수준으로 가벼운 힘으로도 쉽게 붕해되었으며, 붕해된 이미지를 도 5 및 도 6에서 확인할 수 있다. As shown in Table 2 and FIG. 4, the average disintegration hardness of the fast disintegrating granule ring cleaner (Example 1) is 375 g, which is light at about 1/10 of the disintegration hardness of the powder ring cleaner (Comparative Example 1). Disintegrated easily by force, the disintegrated image can be seen in FIGS. 5 and 6.
또한, 수중에서의 붕해 성상은 도 5 및 도 6에 도시된 바와 같으며, 과립환 세정제(실시예 1)의 경우 파우더환 세정제(비교예 1)에 비하여 매우 쉽게 붕해되었으며, 붕해 시간도 10초로 파우더환 세정제(비교예 1)의 20분(=1200초)에 비하여 1/120로 단축되었음이 확인되었다.In addition, the disintegration properties in water are as shown in Figs. 5 and 6, the granular ring cleaner (Example 1) was disintegrated very easily compared to the powder ring cleaner (Comparative Example 1), the disintegration time is 10 seconds It was confirmed that it was shortened to 1/120 as compared with 20 minutes (= 1200 seconds) of the powder ring cleaner (Comparative Example 1).
도 5는 본 발명의 비교예 1에 따른 파우더환 세정제의 제조 후 성상, 붕해 시 성상 및 물과 반응 시 성상을 나타낸 이미지이다. 비교예 1의 파우더환 세정제의 제조 후 성상은 치밀하고 빽빽한 표면을 가지며, 붕해될 때는 3200g의 질량으로 표현되는 힘이 필요했으며, 큰 덩어리로 붕해되고, 물에서는 붕해된 덩어리 내부로 물이 침투하기가 어려운 이유로 완전히 용해시키기까지 시간이 오래 걸렸으며, 죽처럼 끈적끈적한 사용감을 보이는 것을 확인하였다.5 is an image showing the properties after the preparation of the powder ring cleaner according to Comparative Example 1 of the present invention, when disintegrating and reacting with water. After preparation of the powder ring cleaner of Comparative Example 1, the appearance has a dense and dense surface, and when disintegrated, a force expressed in mass of 3200 g was required, and the water disintegrated into a large mass, and the water penetrated into the disintegrated mass. It took a long time to dissolve completely for a difficult reason, and it was confirmed that it showed sticky feeling like porridge.
한편, 도 6은 본 발명의 실시예 1에 따른 속붕해형 과립환 세정제의 제조 후 성상, 붕해 시 성상 및 물과 반응 시 성상을 나타낸 이미지이다. 실시예 1의 속붕해형 과립환 세정제는 제조 후 표면 및 내부에 기공이 형성되며, 분해될 때는 약 300g의 질량으로 표현되는 힘으로 작은 과립으로 붕해되고, 물에서는 작은 과립이 빠르게 물과 반응하여 거품을 형성하였으며, 손에서의 풀림과 거품 형성이 매우 우수한 것을 확인하였다.On the other hand, Figure 6 is an image showing the properties after the preparation of the fast disintegrating granules ring cleaning agent according to Example 1 of the present invention, when disintegrating and the reaction with water. The rapid disintegrating granule ring cleaner of Example 1 forms pores on the surface and inside after preparation, and when disintegrated, it disintegrates into small granules with a force expressed by a mass of about 300 g, and in the water, small granules rapidly react with water. Foam was formed, it was confirmed that the loosening and foam formation in the hand is very excellent.
본 발명의 속붕해형 과립환 세정제는 그 제조공정에 있어서 과립화로 인하여 과립 간 공극을 유지한 채 고형체로 성형되므로, 기존의 파우더를 압축시킨 고형 세정제에 비하여 경도가 현저히 낮으며, 수중 붕해 또는 용해시 입자간 뭉침 현상이 적고 입자 유동성이 우수하기 때문에 붕해 시간을 단축할 수 있다. 따라서 본 발명의 속붕해형 과립환 세정제를 1회 분량으로 나누어 성형하면, 휴대성, 사용 편의성 및 위생성을 도모할 수 있다.Since the fast disintegrating granular ring cleaner of the present invention is molded into a solid body while maintaining the intergranular voids due to granulation in the manufacturing process, the fast disintegrating granular ring detergent is significantly lower in hardness than the solid detergent compressed with the conventional powder, and disintegrates or dissolves in water. The disintegration time can be shortened due to the small particle agglomeration phenomenon and excellent particle fluidity. Therefore, when the fast disintegrating granule ring cleaner of the present invention is divided into one portion and molded, portability, ease of use, and hygiene can be achieved.

Claims (11)

  1. 계면활성제, 발포제 및 붕해제를 포함하는 과립이 결합제에 의해 서로 결합되어 환(pill) 제형을 갖는 것을 특징으로 하는 속붕해형 과립환 모발 세정용 조성물.A fast disintegrating granular ring hair cleaning composition, wherein the granules including the surfactant, the blowing agent, and the disintegrant are bound to each other by a binder to have a pill formulation.
  2. 제1항에 있어서,The method of claim 1,
    상기 속붕해형 과립환 모발 세정용 조성물은 총 중량 내에서 계면활성제 5 내지 55 중량%, 발포제 10 내지 50 중량%, 붕해제 1 내지 25 중량%, 및 결합제 1 내지 30 중량%를 포함하는 것을 특징으로 하는 속붕해형 과립환 모발 세정용 조성물.The fast disintegrating granular ring hair cleaning composition comprises 5 to 55% by weight of surfactant, 10 to 50% by weight of blowing agent, 1 to 25% by weight of disintegrant, and 1 to 30% by weight of binder in the total weight. Sokbung granules ring cleaning composition for hair.
  3. 제1항에 있어서,The method of claim 1,
    상기 계면활성제는 음이온성 계면활성제, 양이온성 계면활성제, 양쪽성 계면활성제, 비이온성 계면활성제 및 이들의 혼합물로 이루어진 군에서 선택된 1종을 포함하는 것을 특징으로 하는 속붕해형 과립환 모발 세정용 조성물.The surfactant is a fast disintegrating granular ring hair cleaning composition, characterized in that it comprises one selected from the group consisting of anionic surfactants, cationic surfactants, amphoteric surfactants, nonionic surfactants and mixtures thereof. .
  4. 제1항에 있어서,The method of claim 1,
    상기 발포제는 무기탄산염 및 약산인 것을 특징으로 하는 속붕해형 과립환 모발 세정용 조성물.The blowing agent Sokbung granules ring hair cleaning composition, characterized in that the inorganic carbonate and weak acid.
  5. 제4항에 있어서,The method of claim 4, wherein
    상기 무기탄산염과 약산의 중량비는 1:0.1 내지 1:0.6으로 함유되는 것을 특징으로 하는 속붕해형 과립환 모발 세정용 조성물.The weight ratio of the inorganic carbonate and the weak acid is 1: 0.1 to 1: 0.6 fast disintegrating granular ring hair cleaning composition, characterized in that it is contained.
  6. 제4항에 있어서,The method of claim 4, wherein
    상기 무기탄산염은 중탄산나트륨(NaHCO3), 중탄산칼륨(KHCO3), 중탄산칼슘(Ca(HCO3)2), 탄산나트륨(Na2CO3), 탄산칼륨(K2CO3), 탄산칼슘(CaCO3) 및 이들의 혼합물로 이루어진 군에서 선택된 1종을 포함하는 것을 특징으로 하는 속붕해형 과립환 모발 세정용 조성물.The inorganic carbonate is sodium bicarbonate (NaHCO 3 ), potassium bicarbonate (KHCO 3 ), calcium bicarbonate (Ca (HCO 3 ) 2 ), sodium carbonate (Na 2 CO 3 ), potassium carbonate (K 2 CO 3 ), calcium carbonate (CaCO 3 ) and a fast disintegrating granular ring hair cleaning composition comprising one selected from the group consisting of these.
  7. 제4항에 있어서,The method of claim 4, wherein
    상기 약산은 구연산(Citric acid), 주석산(Tartaric acid), 인산(Phosphoric acid), 아세트산(Acetic acid), 말레산(Maleic acid), 푸마르산(Fumaric acid) 및 이들의 혼합물로 이루어진 군에서 선택된 1종을 포함하는 것을 특징으로 하는 속붕해형 과립환 모발 세정용 조성물.The weak acid is citric acid (Citric acid), tartaric acid (Tartaric acid), phosphoric acid (Phosphoric acid), acetic acid (Acetic acid), maleic acid (Maleic acid), fumaric acid (Fumaric acid) and one selected from the group consisting of Sokbung granules ring-shaped hair cleaning composition comprising a.
  8. 제1항에 있어서,The method of claim 1,
    상기 붕해제는 전분류(Starches), 미결정 셀룰로오스(Micro crystalline cellulose), 크로스포비돈(Crospovidone), 저치환 하이드록시프로필셀룰로오스(Low-substituted hydroxypropyl cellulose), 크로스카르멜로오스(Croscarmellose) 및 이들의 혼합물로 이루어진 군에서 선택된 1종을 포함하는 것을 특징으로 하는 속붕해형 과립환 모발 세정용 조성물.The disintegrants include starches, micro crystalline cellulose, crospovidone, low-substituted hydroxypropyl cellulose, croscarmellose, and mixtures thereof. Sokbung granules ring hair cleaning composition comprising one selected from the group consisting of.
  9. 제1항에 있어서,The method of claim 1,
    상기 결합제는 글리세린, 실리콘오일류, 폴리올류 및 이들의 혼합물로 이루어진 군에서 선택된 1종을 포함하는 것을 특징으로 하는 속붕해형 과립환 모발 세정용 조성물.The binder is fast disintegrating granular ring hair cleaning composition, characterized in that it comprises one selected from the group consisting of glycerin, silicone oils, polyols and mixtures thereof.
  10. 제1항에 있어서,The method of claim 1,
    상기 과립은 입경이 0.5 내지 1.5mm인 것을 특징으로 하는 속붕해형 과립환 모발 세정용 조성물.The granules are fast disintegrating granular ring hair cleaning composition, characterized in that the particle diameter of 0.5 to 1.5mm.
  11. 제1항에 있어서,The method of claim 1,
    상기 환 제형은 입경이 18 내지 25mm인 것을 특징으로 하는 속붕해형 과립환 모발 세정용 조성물.The ring formulation is fast disintegrating granular ring hair cleaning composition, characterized in that the particle diameter of 18 to 25mm.
PCT/KR2016/006756 2015-06-30 2016-06-24 Fast disintegrating granular hair cleansing composition WO2017003137A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2017568067A JP2018527307A (en) 2015-06-30 2016-06-24 Quick disintegrating granule round hair cleaning composition
CN201680048775.3A CN107920962A (en) 2015-06-30 2016-06-24 The Clean- fater disintegration type graininess ball composition of hair
US15/740,339 US20180193231A1 (en) 2015-06-30 2016-06-24 Fast disintegrating granular hair cleansing composition

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR20150092874 2015-06-30
KR10-2015-0092874 2015-06-30
KR1020160078679A KR20170003414A (en) 2015-06-30 2016-06-23 Fast soluble type granule pill composition for hair washing
KR10-2016-0078679 2016-06-23

Publications (1)

Publication Number Publication Date
WO2017003137A1 true WO2017003137A1 (en) 2017-01-05

Family

ID=57609532

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2016/006756 WO2017003137A1 (en) 2015-06-30 2016-06-24 Fast disintegrating granular hair cleansing composition

Country Status (1)

Country Link
WO (1) WO2017003137A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2603592A (en) * 2020-11-30 2022-08-10 Henkel Ag & Co Kgaa Powder system for the care of hair

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20070094666A (en) * 2005-02-25 2007-09-20 에프. 호프만-라 로슈 아게 Tablets with improved drug substance dispersibility
KR20080076260A (en) * 2007-02-15 2008-08-20 주식회사 엘지생활건강 Tablet or pellet type of personal care product
KR20090028985A (en) * 2007-09-17 2009-03-20 주식회사 엘지생활건강 Pack composition containing terra alba, loess, gypsum, mud or their mixture
WO2010123184A1 (en) * 2009-04-24 2010-10-28 제주대학교 산학협력단 Composition for preventing and treating alopecia disorder containing norgalanthamine compounds as an active ingredient
KR20120136853A (en) * 2011-06-10 2012-12-20 주식회사 엠비오라 Eco washing tablet lot and manufacturing method thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20070094666A (en) * 2005-02-25 2007-09-20 에프. 호프만-라 로슈 아게 Tablets with improved drug substance dispersibility
KR20080076260A (en) * 2007-02-15 2008-08-20 주식회사 엘지생활건강 Tablet or pellet type of personal care product
KR20090028985A (en) * 2007-09-17 2009-03-20 주식회사 엘지생활건강 Pack composition containing terra alba, loess, gypsum, mud or their mixture
WO2010123184A1 (en) * 2009-04-24 2010-10-28 제주대학교 산학협력단 Composition for preventing and treating alopecia disorder containing norgalanthamine compounds as an active ingredient
KR20120136853A (en) * 2011-06-10 2012-12-20 주식회사 엠비오라 Eco washing tablet lot and manufacturing method thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2603592A (en) * 2020-11-30 2022-08-10 Henkel Ag & Co Kgaa Powder system for the care of hair
GB2603592B (en) * 2020-11-30 2023-05-10 Henkel Ag & Co Kgaa Powder system for the care of hair

Similar Documents

Publication Publication Date Title
KR20170003414A (en) Fast soluble type granule pill composition for hair washing
US8920836B2 (en) Particulates
US6387401B2 (en) Use of lipids as adjuvents in the production of solid medicinal forms by the melt extrusion process
US6303108B1 (en) Solid warming pulverulent composition to be hydrated for caring for or cleaning the skin
PL206595B1 (en) Pharmaceutical preparation comprising an active dispersed on a matrix
EP2170273B1 (en) Pharmaceutical formulation for the production of rapidly disintegrating tablets
FI108401B (en) Procedure for Preparation of an Orally Administerable, Solvent-Free Pharmaceutical Preparation with Delayed Release of Active Substance
TWI285117B (en) Medicinal compositions quickly disintegrating in the oral cavity and process for producing the same
KR100759720B1 (en) Tablet rapidly disintegrating in mouth
JPH0439444B2 (en)
WO2017003137A1 (en) Fast disintegrating granular hair cleansing composition
JP3430456B2 (en) Hydrating solid foamable powder composition for skin care or cleansing
HUP0105048A2 (en) Biodegradable polymer encapsulated serotonin receptor antagonist and method for preparing the same
US6451327B1 (en) Skin cleansing composition
JP2013523834A5 (en)
EP3324920B1 (en) Cosmetic composition in the form of a compact powder, manufacturing process and uses thereof
DE19749749A1 (en) Process for the preparation of stable and rapidly disintegrating detergent tablets
KR20010080239A (en) Tablet for crunching with masked taste and instant release of active principle and method for making same
KR102176410B1 (en) Manufacturing method for bath bomb comprising natural surfactant
JP2018002608A (en) Method for producing granula skin cleanser composition
CA2322629A1 (en) Method for producing solid, spherical forms containing pharmaceutical active agents in a binder matrix
KR100731891B1 (en) In-situ melting and gelling tablet composition for oral care
KR101544943B1 (en) Tablet composition for modeling pack and method for preparing a modeling pack using thereof
JP2021167306A (en) Method for producing disintegrative particle
JP2005502630A (en) Pharmaceutical preparation containing LTB4 antagonist

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 16818170

Country of ref document: EP

Kind code of ref document: A1

ENP Entry into the national phase

Ref document number: 2017568067

Country of ref document: JP

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 16818170

Country of ref document: EP

Kind code of ref document: A1