WO2016191824A1

WO2016191824A1 - Improved oxidoreductases for biocatalysis

Info

Publication number: WO2016191824A1
Application number: PCT/AU2016/050449
Authority: WO
Inventors: Elizabeth GILLAM
Original assignee: The University Of Queensland
Priority date: 2015-06-02
Filing date: 2016-06-02
Publication date: 2016-12-08

Abstract

Engineered ancestral P450 enzymes are provided, including engineered ancestral CYP1, CYP2, CYP4, and CYP4F enzymes. Also provided are methods for the production of these engineered ancestral P450 enzymes. The engineered ancestral enzymes may have one or more improved or enhanced properties relative to one or more existing P450 enzymes. These enzymes can be used to perform chemical reactions, such as for structure-activity relationship analysis; pharmacological testing; bioremediation; or biosensor technology.

Description

TITLE

IMPROVED OXIDOREDUCTASES FOR BIOCATALYSIS TECHNICAL FIELD

THE present invention relates to the use of oxidoreductases for biocatalysis. More particularly, the invention relates to isolated, engineered oxidoreductase proteins with improved characteristics for use in biocatalysis, and a process for developing these proteins.

BACKGROUND

Biocatalysis, the use of enzymes to perform chemical transformations of industrial relevance, is emerging as an attractive means of addressing bottlenecks in the synthesis and modification of new chemicals. The basic principle underpinning this is that enzymes can catalyse reactions with greater chemo-, regio- and stereo-selectivity than can be accomplished by purely chemical means. Additionally, biocatalysts have substantial utility in biosensor technology and for bioremediation. Oxidoreductases comprise a major proportion of biocatalysts exploited industrially. The P450 oxidoreductases are amongst the most versatile enzymes known, a property which has made them a high-priority target for exploitation as biocatalysts. Furthermore, P450 oxidoreductases can be used in the preparation of small quantities of metabolites for use as experimental standards, and P450 oxidoreductase-based biocatalytic assays have substantial potential for screening drug candidates.

In microorganisms, P450s tend to be specialized to interact in a highly efficient manner with a relatively small set of structurally related substrates. However, efficiency is generally markedly diminished when microbial P450 forms act on unnatural substrates. In multicellular organisms, certain P450s perform key roles in xenobiotic metabolism, including the metabolism of drugs. These P450s show unusual characteristics compared to other more typical enzyme catalysts in that they act on an extraordinarily wide spectrum of substrates; such xenobiotic -metabolizing P450s may therefore be useful in a broader range of biocatalytic applications. However, known xenobiotic-metabolizing P450s possess relatively poor catalytic efficiency and inefficient coupling of product formation to cofactor consumption when acting on any one substrate, as well as sub-optimal interactions with their principal redox partner, NADPH-cytochrome P450 reductase (referred to variously as NPR or CPR).

Process efficiency considerations mean that it is usually desirable to add high concentrations of substrates and generate high concentrations of product in bioreactors. Achieving high substrate concentrations may necessitate the use of organic solvents at concentrations that are deleterious to the activity or stability of most P450s. Another inherent difficulty with using P450s in an industrial context is their thermal and mechanical instability; this is particularly a problem for the lipophilic, membrane- bound, mammalian P450s, which typically need to be processed and stored in a high concentration of glycerol or some other cryoprotectant. Conducting reactions under increased temperature may also improve efficiency, however at temperatures above which a P450 is stable the deactivation of enzyme will negate efficiency gains.

The identification and/or development of P450s with enhanced properties for industrial applications is clearly desirable. To date, screening libraries of existing P450s for desired properties has been seen as more expedient than engineering a new catalyst from a nonspecialized precursor. However, improvements in protein engineering offer new scope to rapidly customize enzymes. Certain well- characterized and relatively efficient bacterial P450 forms have been engineered to redefine their substrate specificity, regio and enantio-selectivity, and catalytic efficiency. However, one potential limitation of substrate-specific microbial P450-derived mutant proteins, particularly for medicinal chemistry applications, is that they will be unlikely to produce many minor metabolites that may be of interest. Thus, the xenobiotic-metabolising P450s (e.g. mammalian enzymes), may be useful for engineering proteins that can produce a wider range of metabolites.

SUMMARY

The invention is broadly directed to the production of "engineered ancestral" P450 enzymes. It is a preferred object of the invention to provide "engineered ancestral" P450 enzymes that display or possess one or more desirable properties that are at least partly absent in extant P450 enzymes or are relatively enhanced compared to extant P450 enzymes.

The invention is broadly directed to an isolated protein comprising the amino acid sequence of a CYP1 protein, a CYP2 protein, a CYP4 protein and/or a CYP4F protein disclosed herein, or an amino acid sequence at least 80% similar to any one of these.

In a first aspect, the invention provides an isolated protein comprising the amino acid sequence set forth in any one of SEQ ID NOS: 1-159, or an amino acid sequence at least 80% similar to said sequences, or a fragment or derivative thereof.

In a second aspect, the invention provides an isolated protein comprising the amino acid sequence set forth in any one of SEQ ID NOS: 1-23, any one of SEQ ID NOS:64-94, any one of SEQ ID NOS: 142-151, or any one of SEQ ID NOS: 152-155, or an amino acid sequence 80% similar to any one of these or a fragment or derivative thereof, wherein each amino acid sequence comprises residues Xi - X_n> as defined with reference to Tables 1-4.

In one preferred embodiment of the second aspect, one or more of the residues Xi - X_n is selected from the respective group of variable amino acids as set forth in:

Table 1 with respect to SEQ ID NOS: 1-23;

Table 2 with respect to SEQ ID NOS:64-94;

Table 3 with respect to SEQ ID NOS:142-151; or

Table 4 with respect to SEQ ID NOS: 152-155.

In another preferred embodiment of the second aspect, each of the residues Xi - X_n is selected from the respective group of variable amino acids as set forth in:

Table 1 with respect to SEQ ID NOS: 1-23;

Table 2 with respect to SEQ ID NOS:64-94;

Table 3 with respect to SEQ ID NOS:142-151; or

Table 4 with respect to SEQ ID NOS:152-155.

In a third aspect, the invention provides an isolated protein comprising the amino acid sequence set forth in any one of SEQ ID NOS:24-63, SEQ ID NOS:95-125 or SEQ ID NOS: 156-159, or an amino acid sequence 80% similar to any of these, wherein said sequences comprise variations at one or more residues corresponding to Xi - X_n of a respective sequence set forth in SEQ ID NOS: 1-23, SEQ ID NOS:64-94, or SEQ ID NOS: 152-155, respectively. Also provide are fragments and derivatives of the isolated proteins of the second and third aspects.

Suitably, the isolated protein of the first to third aspects has P450 activity.

In a fourth aspect, the invention provides a method of producing or constructing an isolated protein, said method including the step of producing or constructing an engineered ancestral amino acid sequence of at least a fragment of a P450 protein from one or more P450 proteins comprising amino acid sequences that are different to the engineered ancestral amino acid sequence, wherein the engineered ancestral P450 protein is a CYP1, CYP2, CYP4 or CYP4F engineered ancestral protein.

Suitably, the engineered ancestral P450 protein displays or possesses one or more increased or enhanced properties compared to at least one of the one or more P450 proteins comprising amino acid sequences that are different to the engineered ancestral amino acid sequence.

This aspect also relates to an isolated P450 protein produced according to the method of this aspect.

In one embodiment, the isolated protein having P450 enzyme activity is the isolated protein of the first aspect. Preferably, the isolated protein comprises an amino acid sequences set forth in any one of SEQ ID NOS: 1-159.

In a fifth aspect, the invention provides a method of producing or constructing a modified engineered ancestral P450 protein, said method including the step of introducing one or more amino acid substitutions in an amino acid sequence of the engineered ancestral P450 protein to thereby produce or construct the modified engineered ancestral P450 protein, wherein the engineered ancestral P450 protein is a CYPl, CYP2, CYP4 or CYP4F engineered ancestral protein.

In certain preferred embodiments, the amino acid sequence into which the one or more amino acid substitutions is introduced is selected from any one of SEQ ID NOS: 1-23, any one of SEQ ID NOS:47-63, any one of SEQ ID NOS: 142-151, or any one of SEQ ID NOS: 152-155. In preferred embodiments relating to said sequences the amino acid substitutions are at one or more of the residues Xi - X_n, with reference to Tables 1-4, respectively.

In an embodiment of the fifth aspect relating to SEQ ID NOS:24-63, SEQ ID NOS:95-125, and SEQ ID NOS: 156-159, preferably the amino acid substitutions are at one or more residues corresponding to Xi - X_n of a respective sequence set forth in SEQ ID NOS: 1-23, SEQ ID NOS:64-94, or SEQ ID NOS: 152-155, respectively.

Suitably, the modified engineered ancestral P450 protein displays or possesses one or more increased or enhanced properties compared to the engineered ancestral P450 protein.

In certain preferred embodiments, said amino acid substitutions are non-conservative substitutions.

This aspect also relates to a modified engineered ancestral P450 protein.

In a sixth aspect, the invention provides an isolated nucleic acid encoding an isolated protein, fragment or derivative of the first to third aspects, or produced according to the fourth or fifth aspects.

In a seventh aspect, the invention provides a genetic construct comprising an isolated nucleic acid of the sixth aspect. In an eighth aspect, the invention provides a host cell comprising the genetic construct of the seventh aspect.

In a ninth aspect, the invention provides an antibody or antibody fragment which binds and/or is raised against an isolated protein of the first to third aspects, or produce4d according to the fourth or fifth aspects..

A tenth aspect of the invention relates to a composition for performing a chemical reaction, said composition comprising one or more isolated proteins of the first to third aspects, or produced according to the fourth or fifth aspect, and one or more buffers, solvents and/or other reagents suitable for performing the chemical reaction.

An eleventh aspect of the invention relates to a method of performing a chemical reaction, said method including the step of exposing one or more substrate molecules to one or more isolated proteins according to the first to third aspects, or produced according to the fourth or fifth aspects, or a composition of the tenth aspect, to thereby perform the chemical reaction.

A twelfth aspect of the invention relates to a reaction product produced according to the method of the eleventh aspect.

A thirteenth aspect of the invention provides for use of the isolated protein of the first to third aspects, or produced according to the fourth or fifth aspects, or the composition of the tenth aspect, for biocatalysis, preferably for structure-activity relationship analysis; pharmacological testing; bioremediation; or biosensor technology.

It will be appreciated that the indefinite articles "a" and "cm" are not to be read as singular indefinite articles or as otherwise excluding more than one or more than a single subject to which the indefinite article refers. For example, "a" protein includes one protein, one or more proteins or a plurality of proteins.

As used herein, unless the context requires otherwise, the words "comprise", "comprises" and "comprising" will be understood to mean the inclusion of a stated integer or group of integers but not the exclusion of any other integer or group of integers.

BRIEF DESCRIPTION OF THE FIGURES

In order that the invention may be readily understood and put into practical effect, preferred embodiments will now be described by way of example with reference to the accompanying figures.

Figure 1 sets forth amino acid sequences (in FAST A format) of 'AO' engineered ancestral CYP1 enzymes N9_A0; N13_A0; N18_A0; N14_A0; N27_A0; N20_A0; N207_A0; N72_A0; N98_A0; N25_A0; N58_A0; N53_A0; N52_A0; N17_A0; N21_A0; N134_A0; N223_A0; N224_A0; N29_A0; N46 A0; N45 A0; N128 A0; N127 A0. '-' represents a gap.

Figure 2 sets forth amino acid sequences (in FAST A format) of ΆΓ engineered ancestral CYP1 enzymes N9_A1; N13_A1; N18_A1; N14_A1; N27_A1; N20_A1; N207_A1; N72_A1; N98_A1; N25_A1; N58_A1; N53_A1; N52_A1; N17_A1; N21_A1; N134_A1; N223_A1; N224_A1; N29_A1; N46_A1; N45_A1; N128_A1; N127_A1.

Figure 3 sets forth amino acid sequences (in FAST A format) of Ά2' engineered ancestral CYP1 enzymes lAl Mammalia; lA2_Mammalia; lB Mammal; 1A4-Aves; lA5-Aves_&_lA4-Aves; 1A; 1A5-Aves; lA_Mamallia_&_lA_Reptile_&_lA_ Amphibia; lA-Actinopterygii; IAD; ID; 1ADBC; lD Mammalia; IC Actinopterygii; 1BC; lB Actinopterygii; IB.

Figure 4 sets forth amino acid sequences (in FAST A format) of 'AO' engineered ancestral CYP2 enzymes N3_A0; N8_A0; N13_A0; N24_A0; N38_A0; N54_A0; N81_A0; N82_A0; N118_A0; N159_A0; N200_A0; N312_A0; N117_A0; N157_A0; N196_A0; N37_A0; N77_A0; N112_A0; N23_A0; N35_A0; N47_A0; N69_A0; N70_A0; N140_A0; N98_A0; N218_A0; N133_A0; N134_A0; N169 A0; N170 A0; N97 A0. '-' represents a gap.

Figure 5 sets forth amino acid sequences (in FAST A format) of ΆΓ engineered ancestral CYP2 enzymes N3_A1; N8_A1; N13_A1; N24_A1; N38_A1; N54_A1; N81_A1; N82_A1; N118_A1; N159_A1; N200_A1; N312_A1; N117_A1; N157_A1; N196_A1; N37_A1; N77_A1; N112_A1; N23_A1; N35_A1; N47_A1; N69_A1; N70_A1; N140_A1; N98_A1; N218_A1; N133_A1; N134_A1; N169_A1; N170_A1; N97_A1.

Figure 6 sets forth amino acid sequences (in FAST A format) of Ά2' engineered ancestral CYP2 enzymes 2A_Mammal; 2AG; 2B_Mammal; 2BS; 2BSAG; 2Cl_Mammal; 2C2_Mammal; 2CE_Mammal; 2CE_Mammal_&_2C_Reptile_&_2C_Aves; 2CEH; 2E_Mammal; 2F_Mammal; 2FT; 2H; 2S_Mammal; 2C_Aves.

Figure 7 sets forth amino acid sequences (in FASTA format) of 'AO' engineered ancestral CYP4F enzymes N0_A0; N4_A0; N9_A0; N10_A0; N105_A0; N129_A0; N151_A0; N195_A0; N261_A0; N337_A0.

Figure 8 sets forth amino acid sequences (in FASTA format) of 'AO' engineered ancestral

CYP4ABXZ enzymes N2 A0; N4 A0; N122 A0; and N198 A0.

Figure 9 sets forth thermostability profiles of the CYP2 engineered ancestral enzyme and, where present, selected extant proteins, after heating for A) 10 minutes and B) 60 minutes. Data represent the mean +/- standard deviation (SD) of three biological replicates.

(I) CYP2 N312 A1 (labelled CYP2A) engineered ancestral enzyme compared to extant

CYP2a5, CYP2A6 and CYP2A13;

(II) CYP2 N157 A1 (labelled CYP2B) engineered ancestral enzyme compared to extant CYP2B6 and CYP2Bl;

(III) CYP2 N133 A1 (labelled CYP2C) engineered ancestral enzyme compared to extant proteins CYP2C8, CYP2C9, CYP2C11 and CYP2C19;

(IV) CYP2 N170 A1 (labelled CYP2E) engineered ancestral enzyme compared to extant protein CYP2E1;

(V) CYP2 N77 A1 (labelled CYP2F) engineered ancestral enzyme compared to and an extant protein CYP2F3;

(VI) CYP2 N196 A1 (labelled CYP2S) engineered ancestral enzyme compared to extant protein CYP2S1;

(VII) CYP2 N117 A1 (labelled CYP2ABGSFT), CYP2 N82 A1 (labelled CYP2ABGS), and CYP2 N24 A1 (labelled CYP2BS) engineered ancestral enzymes;

(VIII) CYP2 N69 A1 (labelled CYP2ABGSFTCEH), CYP2 N23 A1 (labelled CYP2CEH), and CYP2 N13 A1 (labelled CYP2CE) engineered ancestral enzymes. Figure 10 sets forth ligand binding curves for engineered ancestral CYP2 enzymes for clopidogrel, ticlopidine and ritonavir, or in the case of (V), binding to clopidogrel and ritonavir. (I) CYP2 N157; (II) CYP2 N117; (III) CYP2 N82; (IV) CYP2 N24; (V) CYP2 N13.

Figure 11 sets forth an overview of the processes used to generate engineered ancestral sequences from a pool of extant sequence data, for CYP4ABXZ. It will be appreciated that a similar process was used for generation of CYP1, CYP2, and CYP4F ancestral sequences. The sequences were first obtained by text and BLAST searching the Uniprot and NCBI databases. The resulting sequences were narrowed down to one sequence per gene per organism, both manually and through the use of the clustering website CD-HIT. Remaining sequences were aligned using the Clustal or MAFFT methods, and anomalous sequences were removed (i.e. those with sequencing errors, incomplete ORFs, internal gaps >10 residues, or <55% local or global identity to other forms). Insertions that were present in only a minority of sequences were removed. Sequences were then realigned with a closely related outgroup sequence from outside the clade of interest, and a phylogenetic tree was generated using ML with bootstrapping. The MSA and tree were sent to FastML for reconstruction using the Joint method, and the ancestral sequence for the node of interest was downloaded.

Figure 12 sets forth thermostability profiles of the CYP4ABXZ engineered ancestral enzyme and selected extant proteins.

Figure 13 sets forth a phylogenetic tree containing the sequences used to reconstruct the CYP4ABXZ ancestors.

Figure 14 sets forth an expanded view of the CYP4B clade (N4) from the previous the tree depicted in Figure 13. Although some sequences appear to be phylogenetically misplaced (labelled as unusual CYP4As), BLAST searching revealed that these sequences are actually highly homologous to CYP4B1 enzymes, and as such they are probably mis-annotated CYP4B1 enzymes.

Figure 15 sets forth amino acid sequences of engineered ancestral CYP4 proteins CYP4ABXZ (CYP4BXZ N2 A1); CYP4B (CYP4 ABXZ N4 A 1 ) ; CYP4A (CYP4 ABXZ N 122 A 1 ) ; CYP4XZ (CYP4 ABXZ Nl 98 A 1) .

BRIEF DESCRIPTION OF THE SEQUENCE LISTING SEQ ID NOS: l-23: Amino acid sequences of AO engineered ancestral CYPl enzymes N9 A0;

N13_A0; N18_A0; N14_A0; N27_A0; N20_A0; N207_A0; N72_A0; N98_A0; N25_A0; N58_A0; N53_A0; N52_A0; N17_A0; N21_A0;

N134_A0; N223_A0; N224_A0; N29_A0; N46_A0; N45_A0; N128_A0; and N127_A0

SEQ ID NOS:24-46: Amino acid sequences of Al engineered ancestral CYPl enzymes N9 A1;

N13_A1; N18_A1; N14_A1; N27_A1; N20_A1; N207_A1; N72_A1; N98_A1; N25_A1; N58_A1; N53_A1; N52_A1; N17_A1; N21_A1;

N134_A1; N223_A1; N224_A1; N29_A1; N46_A1; N45_A1; N128_A1; and N127_A1.

SEQ ID NOS:47-63: Amino acid sequences of A2 engineered ancestral CYPl enzymes lAl Mammalia; lA2_Mammalia; lB Mammal; 1A4-Aves; 1A5- Aves_&_lA4-Aves; 1A; 1A5-Aves; lA_Mamallia_&_lA_Reptile_&_lA_Amphibia; lA-Actinopterygii; IAD; ID; 1ADBC; lD Mammalia; lC Actinopterygii; 1BC; lB Actinopterygii; and IB.

SEQ ID NOS:64-94: Amino acid sequences of AO engineered ancestral CYP2 enzymes N3 0;

N8_A0; N13_A0; N24_A0; N38_A0; N54_A0; N81_A0; N82_A0; Nl 18 A0;

N159_A0; N200_A0; N312_A0; N117_A0; N157_A0; N196_A0; N37_A0; N77_A0; N112_A0; N23_A0; N35_A0; N47_A0; N69_A0; N70_A0; N140_A0; N98_A0; N218_A0; N133_A0; N134_A0; N169_A0; N170_A0; and N97 A0.

SEQ ID NOS:95-125: Amino acid sequences of Al engineered ancestral CYP2 enzymes N3 1;

N8_A1; N13_A1; N24_A1; N38_A1; N54_A1; N81_A1; N82_A1; N118_A1;

N159_A1; N200_A1; N312_A1; N117_A1; N157_A1; N196_A1; N37_A1;

N77_A1; N112_A1; N23_A1; N35_A1; N47_A1; N69_A1; N70_A1;

N140_A1; N98_A1; N218_A1; N133_A1; N134_A1; N169_A1; N170_A1; and N97_Al.

SEQ ID NOS: 126-141: Amino acid sequences of A2 engineered ancestral CYP2 enzymes

2A_Mammal; 2AG; 2B_Mammal; 2BS; 2BSAG; 2Cl_Mammal;

2C2_Mammal; 2CE_Mammal; 2CE_Mammal_&_2C_Reptile_&_2C_Aves;

2CEH; 2E_Mammal; 2F_Mammal; 2FT; 2H; 2S_Mammal; and 2C_Aves. SEQ ID NOS: 142-151: Amino acid sequences of AO engineered ancestral CYP4F enzymes N0 A0;

N4_A0; N9_A0; N10_A0; N105_A0; N129_A0; N151_A0; N195_A0;

N261_A0; and N337_A0.

SEQ ID NOS: 152-155: Amino acid sequences of AO engineered ancestral CYP4ABXZ enzymes

N2_A0; N4_A0; N122_A0; and N198_A0.

SEQ ID NOS: 156-159:: Amino acid sequences of Al engineered ancestral CYP4ABXZ enzymes

CYP4ABXZ (CYP4BXZ N2 A1); CYP4B (CYP4 ABXZ N4 A 1 ) ; CYP4A (CYP4 ABXZ N122 A 1) ; CYP4XZ (CYP4ABXZ N198 A1).

SEQ ID NOS: 160-162: Amino acid sequences N-terminal modifications.

DETAILED DESCRIPTION

This invention relates to the design and production of engineered P450 enzymes that represent enzymes ancestral to extant P450 enzymes. The invention is at least partly predicated on the surprising discovery that said engineered ancestral enzymes P450 enzymes may have one or more increased or enhanced properties relative to one or more extant P450 enzymes.

For example, in certain embodiments an engineered ancestral enzyme of the invention has substantially increased thermal stability. This is a highly surprising discovery because the temperature conditions to which the hypothetical engineered ancestral enzyme may have been exposed are likely to be substantially similar to the temperature conditions to which one or more corresponding extant enzymes are exposed.

In other particular embodiments, "engineered ancestral" CYPl enzymes have been created which are putative or hypothetical ancestors of extant P450 enzymes. In other particular embodiments, "engineered ancestral" CYP2 enzymes have been created which are putative or hypothetical ancestors of extant P450 enzymes. In other particular embodiments, "engineered ancestral" CYP4 enzymes have been created which are putative or hypothetical ancestors of extant P450 enzymes. In other particular embodiments, "engineered ancestral" CYP4F enzymes have been created which are putative or hypothetical ancestors of extant P450 enzymes.

Furthermore, amino acid residues in the engineered ancestral CYP1, CYP2, CYP4, and CYP4F P450 enzymes have been identified that may be modified to confer, modify or remove one or more properties of the P450 enzymes. These include substrate specificity or promiscuity, thermal stability, pH stability and kinetic properties, although without limitation thereto.

For the purposes of this invention, by "isolated" is meant material that has been removed from its natural state or otherwise been subjected to human manipulation. Isolated material may be substantially or essentially free from components that normally accompany it in its natural state, or may be manipulated so as to be in an artificial state together with components that normally accompany it in its natural state. Isolated material may be in native, chemical synthetic or recombinant form.

By "protein" is meant an amino acid polymer. The amino acids may be natural or non-natural amino acids, D- or L- amino acids as are well understood in the art.

A "peptide" is a protein having no more than fifty (50) amino acids.

A "polypeptide" is a protein having more than fifty (50) amino acids.

As used herein terms such as "oxidizing" and "oxidation" refer to increasing the oxidation state of an atom, molecule or ion through a loss or transfer of one or more electrons from the atom, molecule or ion. Typically, oxidation is accompanied by an associated reduction in oxidation state of another atom, molecule or ion through a gain or transfer of one or more electrons by or to the atom, molecule or ion. These associated or linked changes in oxidation state are referred to as "redox" reactions.

As used herein a "P450 enzyme" or a "protein having P450 enzyme activity" is a protein having one or more activities of a P450 enzyme. A preferred activity is monooxygenase activity according to the reaction: RH + 0₂ +NAD(P)H + H⁺ ROH +H₂0 +NAD(P)⁺ where R is a carbon-containing heteroatom. Particular, non-limiting examples of such reactions include hydroxylation at aromatic and aliphatic centres, epoxidation, N-, 0-, S-dealkylation and N-, and S-oxidation, acyl migration, oxidative dehalogenation, ring expansion, contraction and cleavage, C-C bond cleavage, denitrosation of N- mtrosamines, oxidative ester cleavage, aldehyde scissions (e.g to alkenes and HCOOH), ipso attack on aromatic ring substituents and N- or O-dearylation. One or more other activities may include NO synthase-like activity, reductase activity (e.g. reductions of alkyl halides, N-oxides, nitro compounds, inorganic molecules such as S0₂, Cr(VI) or NO, desaturations (e.g. dehydrogenations), one electron oxidations, isomerizations and/or phospholipase D activity (e.g phosphate ester hydrolysis). As used herein, "CYP1 protein" or "CYP1 enzyme" refers to another particular class or family of proteins having P450 enzyme activity. As used herein, "CYP2 protein" or "CYP2 enzyme" refers to another particular class or family of proteins having P450 enzyme activity. As used herein, "CYP4 protein" or "CYP4 enzyme" refers to a particular class or family of proteins having P450 enzyme activity. As used herein, "CYP4ABXZ protein" or "CYP4ABXZ enzyme" refers to a particular class or family of proteins having P450 enzyme activity. As used herein, CYP4F protein ' or CYP4F enzyme ' refers to a particular class or family of proteins having P450 enzyme activity.

Typically, a redox partner is required for redox activity of a P450 enzyme. As used herein, a "redox partner" is a protein that facilitates the transfer of electrons from an electron donor molecule to a P450 enzyme. Generally, the redox partner of a P450 enzyme is a P450 reductase, although without limitation thereto.

As used herein, a "P450 reductase^'" or a "protein having P450 reductase activity" is a protein having one or more activities of a P450 reductase enzyme. A preferred activity is the transfer of electrons from an electron donor molecule to a P450 enzyme. As used herein, "CPR protein" or "CPR enzyme" refers to the "cytochrome P450 reductase" class or family of proteins having P450 reductase activity. Generally, a CPR enzyme comprises a "flavin adenine dinucleotide" ("FAD") -binding domain and a "flavin mononucleotide" ("FMN") -binding domain. The general scheme of electron flow during redox reactions involving CPR and P450 enzymes is: NADPH→ FAD→ FMN→ P450→ 0_2, although without limitation thereto.

It will be appreciated that a P450 enzyme may have a diverse array of substrates including testosterone, progesterone, midozalam, nifedipine, tamoxifen, 9harmacodyna A, erythromycin, cyclophosphamide, paracetamol, lignocaine, ethosuximide, codeine, lovastatin, 7-benzyloxy-4- (trifluoromethyl)-coumarin, 7-benzyloxyresorufm, terfenadine, S-omeprazole and benzyloxyluciferin; pesticides such as organochlorine pesticide, an organophosphate pesticide, or a pyrethroid pesticide; solvents such as perchloroethylene (PCE) or trichloroethylene (TCE); and food contaminants such as carbamate or organophosphate pesticide residues, although without limitation thereto.

Isolated proteins

In some embodiments, the isolated proteins comprising the amino acid sequence set forth in SEQ ID NOS: 1-63, and variants thereof, may be referred to as proteins having P450 activity that is "ancestral" to one or more extant CYP1 proteins.

In some embodiments, the isolated proteins comprising the amino acid sequence set forth in SEQ ID NOS:64-141, and variants thereof, may be referred to as proteins having P450 activity that is "ancestral" to one or more extant CYP2 proteins.

In some embodiments, the isolated proteins comprising the amino acid sequence set forth in SEQ

ID NOS: 152-159, and variants thereof, may be referred to as proteins having P450 activity that is "ancestral" to one or more of extant CYP4 proteins, e.g. the proteins set out in Figures 13 and 14. The amino acid sequences (incorporated herein by reference to respective UniProt or NCBI accessions) used to generate the phylogenetic tree set forth in Figure 13, are the amino acid sequences of certain extant CYP4 (CYP4A, CYP4X, and CYP4Z) proteins of animals. The amino acid sequences (incorporated herein by reference to respective UniProt or NCBI accessions) used to generate the phylogenetic tree set forth in Figure 14, are the amino acid sequences of certain extant CYP4 (CYP4B) proteins of animals.

In some embodiments, the isolated proteins comprising the amino acid sequence set forth in SEQ ID NOS: 142-151, and variants thereof, may be referred to as proteins having P450 activity that is "ancestral" to one or more extant CYP4F proteins. Suitably, the isolated engineered ancestral CYP1 enzymes comprising any one of the sequences set forth in SEQ ID NOS: l-63, and variants thereof, have one or more improved or enhanced properties, as hereinbelow described, compared to one or more isolated extant CYP1 proteins.

Suitably, the isolated engineered ancestral CYP2 enzymes comprising any one of the sequences set forth in SEQ ID NOS:64-141, and variants thereof, have one or more improved or enhanced properties, as hereinbelow described, compared to one or more isolated extant CYP2 proteins.

Suitably, the isolated engineered ancestral CYP4 enzymes comprising any one of the sequences set forth in SEQ ID NOS: 152-159, and variants thereof, have one or more improved or enhanced properties, as hereinbelow described, compared to one or more isolated extant CYP4 proteins.

Suitably, the isolated ancestral CYP4F enzymes comprising any one of the sequences set forth in

SEQ ID NOS: 142- 151, and variants thereof, have one or more improved or enhanced properties, as hereinbelow described, compared to one or more isolated extant CYP4F proteins.

Non-limiting examples of the one or more improved properties of an engineered ancestral CYP1, CYP2, CYP4, or CYP4F enzyme as herein described include: thermal stability, stability in solvents (e.g. organic solvents), metabolite production, catalytic versatility, catalytic efficiency (e.g. the efficiency of coupling of product formation to cofactor consumption), substrate specificity (e.g. increased specificity or increased genericity, as desired) and enzyme kinetic properties (e.g increased V_max, lower K_m), although without limitation thereto.

Certain embodiments also relate to fragments of the isolated proteins disclosed herein.

In one embodiment, a protein "fragment" includes an amino acid sequence that constitutes less than 100%, but at least 20%, 30%, 40%, 50%, 60%, 70%, 80% or 90-99% of said isolated protein.

In another embodiment, a protein fragment comprises no more than 6, 10, 12, 15, 20, 30, 40, 50, 60, 70, 80, 90, 100, 120, 150, 200, 250, 300, 350 or 400 contiguous amino acids of the isolated protein.

In a preferred embodiment, the protein fragment has one or more activities of a P450 enzyme or P450 reductase enzyme as hereinbefore described.

In certain embodiments, the protein fragment does not comprise an N-terminal "membrane anchor" region, or comprise a partial N-terminal membrane anchor region.

In some embodiments, an isolated ancestral protein of the invention may comprise the N- terminal amino acid sequence MALLLAVFL (SEQ ID NO: 160), which may assist with protein expression, in place of a native N-terminal amino acid sequence.

In some embodiments, an isolated ancestral protein of the invention may comprise the N- terminal amino acid sequence: MALLLAVFLGPVAASPWLLL

LLVGGSWLLARVLAWTYTFYDNCRRLQCF (SEQ ID NO:161), which may assist with protein expression, in place of a native N-terminal amino acid sequence.

In some embodiments, an isolated ancestral protein of the invention may comprise the N- terminal amino acid sequence MAKKTSS (SEQ ID NO: 162), which may assist with protein expression, in place of a native N-terminal amino acid sequence.

In some preferred embodiments, the invention relates to the engineered ancestral CYPl sequences set forth in SEQ ID NOS: 1-23, which are herein referred to as CYPl 'AO' sequences, or fragments or variants thereof. It will be appreciated that these sequences were produced using the 'whole tree' approach as described in the examples, and feature gaps which relate to the alignment of the precursor sequences used to generate said sequences, and which gaps assist in defining preferred variation within the sequences, with reference to Table 1. It will be understood that an isolated CYP1 sequences with the sequence set forth in any one of SEQ ID NOS:l-23 possess the sequence of the amino acid residues, in consecutive order, without the gaps.

In some preferred embodiments, the invention relates to the engineered ancestral CYP1 sequences set forth in SEQ ID NOS:24-46, which are herein referred to as ΆΓ sequences, or fragments or variants thereof. It will be appreciated that these sequences were produced using the 'whole tree' approach as described in the examples, and correspond to the AO sequences with the same 'N' identifier (i.e. N9 A1 corresponds to N9 A0). However, the Al sequences set forth in SEQ ID NOS:24-46 differ from the AO sequences set forth in SEQ ID NOS:l-23, in that gap sequences are excluded, and the native N-terminal regions has been replaced with MAKKTSS, as hereinabove described.

In some preferred embodiments, the invention relates to the engineered ancestral CYP1 sequences set forth in SEQ ID NOS:47-63, which are herein referred to as CYP1 Ά2' sequences, or fragments or variants thereof. It will be appreciated that these sequences were produced using the 'subfamily' approach and are related to particular Al and AO sequences, as described in the examples. The relationship of CYP1 A2 sequences to CYP1 Al and AO sequences is set forth in Table 12.

In some preferred embodiments, the invention relates to the engineered ancestral CYP2 sequences set forth in SEQ ID NOS:64-94, which are herein referred to as CYP1 'AO' sequences, or fragments or variants thereof. It will be appreciated that these sequences were produced using the 'whole tree' approach as described in the examples, and feature gaps which relate to the alignment of the precursor sequences used to generate said sequences, which gaps assist in defining preferred variation within the sequences, with reference to Table 2. It will be understood that isolated CYP2 sequences with the sequence set forth in any one of SEQ ID NOS: 64-94 possess the sequence of the amino acid residues, in consecutive order, without the gaps.

In some preferred embodiments, the invention relates to the engineered ancestral CYP2 sequences set forth in SEQ ID NOS:95-125. It will be appreciated that these sequences were produced using the 'whole tree' approach as described in the examples, and correspond to the AO sequences with the same 'N' identifier (i.e. N13 A1 corresponds to N13 A0). However, the Al sequences set forth in SEQ ID NOS:95-125 differ from the AO sequences set forth in SEQ ID NOS:64-94, in that gap sequences are excluded, and the native N-terminal regions has been replaced with MAKKTSS, as hereinabove described.

In some preferred embodiments, the invention relates to the engineered ancestral CYP2 sequences set forth in SEQ ID NOS:126-141. It will be appreciated that these sequences were produced using the 'subfamily' approach as described in the examples, and are related to particular Al and AO sequences. The relationship of CYP2 A2 sequences to CYP2 Al and AO sequences is set forth in Table 13.

In some preferred embodiments, the invention relates to the engineered ancestral CYP4F sequences set forth in SEQ ID NOS: 142-151, which are herein referred to as CYP4F 'AO' sequences, or fragments or variants thereof. It will be appreciated that these sequences were produced using the 'whole tree' approach as described in the examples, and feature gaps which relate to the alignment of the precursor sequences used to generate said sequences, and which gaps assist in defining preferred variation within the sequences, with reference to Table 3. It will be understood that isolated CYP4F sequences with the amino acid sequence set forth in any one of SEQ ID NOS: 142-151 possess the sequence of the amino acid residues, in consecutive order, without the gaps.

In some preferred embodiments, the invention relates to the engineered ancestral CYP4ABXZ sequences set forth in SEQ ID NOS: 152-155, which are herein referred to as CYP4ABXZ 'AO' sequences, or fragments or variants thereof. It will be appreciated that these sequences were produced using the 'whole tree' approach as described in the examples, and feature gaps which relate to the alignment of the precursor sequences used to generate said sequences, and which gaps assist in defining preferred variation within the sequences, with reference to Table 4. It will be understood that an isolated CYP4ABXZ sequence with the amino acid sequence set forth in any one of SEQ ID NOS: 152-155 possess the sequence of the amino acid residues, in consecutive order, without the gaps.

In some preferred embodiments, the invention relates to the engineered ancestral CYP4ABXZ sequences set forth in SEQ ID NOS: 156-159. It will be appreciated that these sequences were produced using the 'whole tree' approach as described in the examples, and correspond to the AO sequences with the same 'N' identifier (e.g. CYP4ABXZ N2 A0 corresponds to CYP4 ABXZ N2 A 1 ) . However, the Al sequences set forth in SEQ ID NOS: 156-159 differ from the AO sequences set forth in SEQ ID NOS: 152-155, in that gap sequences are excluded, and the native N-terminal regions has been replaced, as hereinabove described.

Variants

Certain embodiments of invention also relate to variants of an isolated protein of the invention. In a preferred embodiment, the protein variant has one or more activities of a P450 enzyme as hereinbefore described.

As used herein "variant" proteins of the invention have one or more amino acids deleted or substituted by different amino acids. It is well understood in the art that some amino acids may be substituted or deleted without changing the activity of the protein ("conservative" substitutions). More substantial changes to activity may be made by introducing substitutions or deletions that are less conservative ^non-conservative" substitutions).

Preferably, protein variants share at least 70% or 75%, preferably at least 80% or 85% or more preferably at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% sequence identity with an amino acid sequence of the isolated protein.

In other preferred embodiments, protein variants share at least 80% or 85% or more preferably at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% sequence identity with an amino acid sequence of the isolated protein, excluding the N-terminal membrane anchor region of said protein.

In certain embodiments, the protein fragment does not comprise an N-terminal "membrane anchor" region. As will be understood by one skilled in the art, the N-terminal membrane anchor region of a P450 enzyme or P450 reductase enzyme of the invention may be substantially modified without substantially affecting the function of said protein.

Terms used generally herein to describe sequence relationships between respective proteins and nucleic acids include "comparison window", "sequence identity", "percentage of sequence identity" and "substantial identity". Because respective nucleic acids/proteins may each comprise (1) only one or more portions of a complete nucleic acid/protein sequence that are shared by the nucleic acids/proteins, and (2) one or more portions which are divergent between the nucleic acids/proteins, sequence comparisons are typically performed by comparing sequences over a "comparison window" to identify and compare local regions of sequence similarity. A "comparison window ' refers to a conceptual segment of typically 6, 9 or 12 contiguous residues that is compared to a reference sequence. The comparison window may comprise additions or deletions (i.e., gaps) of about 20% or less as compared to the reference sequence for optimal alignment of the respective sequences. Optimal alignment of sequences for aligning a comparison window may be conducted by computerised implementations of algorithms (Geneworks program by Intelligenetics; GAP, BESTFIT, FAST A, and TFASTA in the Wisconsin Genetics Software Package Release 7.0, Genetics Computer Group, 575 Science Drive Madison, WI, USA, incorporated herein by reference) or by inspection and the best alignment (i.e., resulting in the highest percentage homology over the comparison window) generated by any of the various methods selected. Reference also may be made to the BLAST family of programs as for example disclosed by Altschul et ah, 1997, Nucl. Acids Res. 25 3389, which is incorporated herein by reference. A detailed discussion of sequence analysis can be found in Unit 19.3 of CURRENT PROTOCOLS IN MOLECULAR BIOLOGY Eds. Ausubel et al. (John Wiley & Sons Inc NY, 1995-1999).

The term "sequence identity is used herein in its broadest sense to include the number of exact nucleotide or amino acid matches having regard to an appropriate alignment using a standard algorithm, having regard to the extent that sequences are identical over a window of comparison. Thus, a "percentage of sequence identity is calculated by comparing two optimally aligned sequences over the window of comparison, determining the number of positions at which the identical nucleic acid base (e.g., A, T, C, G, U) occurs in both sequences to yield the number of matched positions, dividing the number of matched positions by the total number of positions in the window of comparison (i.e., the window size), and multiplying the result by 100 to yield the percentage of sequence identity. For example, "sequence identity may be understood to mean the "match percentage" calculated by the DNASIS computer program (Version 2.5 for windows; available from Hitachi Software engineering Co., Ltd., South San Francisco, California, USA).

Certain preferred embodiments of the invention relate to variants of the AO CYPl ancestral sequences set forth in SEQ ID NOS: 1-23.

Preferably, variants of the CYPl ancestral sequences set forth in SEQ ID NOS: 1-23, comprise amino acid variation at one or more of the amino acid residues Xi - X_n, as set forth under the respective heading in Table 1. Detail regarding interpretation of the Table 1 data is provided in the table description below. By way of example, preferred variants of the CYPl AO ancestral sequence CYP1 N9 A0 comprise amino acid variation at one or more of the amino acid residues Xi - X^ set forth in Table 1 under the heading '(i) N9'.

Preferably, the amino acid at one or more of the amino acid residues Xi - X_n is selected from the group of consisting of the respective preferred amino acid variants given in Table 1. By way of example, at residue X₅, preferred variants of CYP1 N9 A0 comprise an amino acid selected from the group consisting of: a deletion; L; M; A; P; and T.

Certain other preferred embodiments of the invention relate to variants of the Al and A2 CYP1 ancestral sequences. Preferably, variation in the Al and A2 CYP1 sequences corresponds to that for the AO CYPl sequences, with reference to Table 1. It will be understood that variation corresponding to that set forth in Table 1 in relation to the AO CYPl sequences set forth in SEQ ID NOS: l-23 can be readily determined for the Al CYPl sequences set forth in SEQ ID NOS:24-46, and the A2 CYPl sequences set forth in SEQ ID NOS:47-63 in view of the relationship of the AO, Al, and A2 sequences, as herein described, for example using bioinformatic tools known to those skilled in the art.

Certain preferred embodiments of the invention relate to variants of the AO CYP2 ancestral sequences set forth in SEQ ID NOS:64-94.

Preferably, variants of the CYP2 ancestral sequences set forth in SEQ ID NOS:64-94, comprise amino acid variation at one or more of the amino acid residues Xi - X_n , as set forth under the respective heading in Table 2. Detail regarding interpretation of the Table 2 data is provided in the table description below. By way of example, preferred variants of the CYP2 ancestral sequence CYP2 N13 A0 comprise amino acid variation at one or more of the amino acid residues Xi - X444 set forth in Table 2 under the heading '(iii) N13 '.

Preferably, the amino acid at one or more of the amino acid residues Xi - X_n is selected from the group of consisting of the respective preferred amino acid variants given in Table 2. By way of example, at residue X₅, preferred variants of N13 A0 comprise an amino acid selected from the group consisting of: a deletion; G; S; and E.

Certain other preferred embodiments of the invention relate to variants of the Al and A2 CYP2 ancestral sequences. Preferably, variation in the A 1 and A2 CYP2 sequences corresponds to that for the AO CYP2 sequences, with reference to Table 2. It will be understood that variation corresponding to that set forth in Table 2 in relation to the AO CYP2 sequences set forth in SEQ ID NOS:64-94 can be determined for the Al CYP2 sequences set forth in SEQ ID NOS:95-125, and the A2 CYP2 sequences set forth in SEQ ID NOS: 126-141 in view of the relationship of the AO, Al, and A2 sequences, as herein described, for example using bioinformatic tools known to those skilled in the art.

Certain preferred embodiments of the invention relate to variants of the AO CYP4F ancestral sequences set forth in SEQ ID NOS: 142-151.

Preferably, variants of the AO CYP4F ancestral sequences set forth in SEQ ID NOS: 142-151 comprise amino acid variation at one or more of the amino acid residues Xi - X_n, as set forth under the respective heading in Table 3. By way of example, preferred variants of the CYP4F ancestral sequence CYP4F N0 A0 comprise amino acid variation at one or more of the amino acid residues Xi - X₃₉i set forth in Table 3 under the heading '(i) NO'. Preferably, the amino acid at one or more of the amino acid residues Xi - X_n is selected from the group of consisting of the respective preferred amino acid variants given in Table 3. By way of example, at residue X₇, preferred variants of CYP4F N0 A0 comprise an amino acid selected from the group consisting of: S; L; and V.

Certain preferred embodiments of the invention relate to variants of the AO CYP4ABXZ ancestral sequences set forth in SEQ ID NOS: 152-155.

Preferably, variants of the AO CYP4ABXZ ancestral sequences set forth in SEQ ID NOS: 152- 155 comprise amino acid variation at one or more of the amino acid residues Xi - X_n, as set forth under the respective heading in Table 4. By way of example, preferred variants of the CYP4ABXZ ancestral sequence CYP4 ABXZ N2 A0 comprise amino acid variation at one or more of the amino acid residues Xi - X₄ii set forth in Table 4 under the heading '(i) N2'.

Preferably, the amino acid at one or more of the amino acid residues Xi - X_n is selected from the group of consisting of the respective preferred amino acid variants given in Table 1. By way of example, at position Xi, preferred variants of CYP4ABXZ N2 A0 comprise an amino acid selected from the group consisting of: L; V; a deletion; F; I; and M.

Certain other preferred embodiments of the invention relate to variants of Al ancestral CYP4ABXZ sequences. Preferably, variation in the Al CYP4ABXZ sequences corresponds to that for the AO CYP4ABXZ sequences, with reference to Table 4. It will be understood that variation corresponding to that set forth in Table 4 in relation to the AO CYP4ABXZ sequences set forth in SEQ ID NOS: 152-155 can readily be determined for the Al CYP4ABXZ sequences set forth in SEQ ID NOS: 149-152, in view of the relationship of the AO and Al sequences, as herein described, for example using bioinformatic tools known to those skilled in the art.

Preferably, variants of CYPl, CYP2, CYP4F, or CYP4ABXZ sequences as herein described do not contain variation at one or more of the amino acid positions which are not listed as X residues in Tables 1-4. In some embodiments, such amino acid positions may be referred to as 'conserved' positions. Preferably, said variants do not contain variation at any of said conserved positions.

In some preferred embodiments, variants of CYPl, CYP2, CYP4F, or CYP4ABXZ sequences as herein described do not contain variation at one or more of the amino acid positions corresponding to Xi - X_n, wherein the most frequent amino acid residue in the alignment used to construct the AO sequence is 80% or less. In some embodiments, such amino acid positions may be referred to as 'semi-conserved' positions. Preferably, said variants do not contain variation at any of said semi-conserved positions.

In this respect, as hereinbelow described, the frequency of the preferred amino acid variants for a given AO sequence, at a given amino acid X residue, is presented in respective Tables 1-4.

By way of example with respect to CYPl variants, Table 1 sets forth that for CYP1 N9 A0, at residue X₂o4 (corresponding to amino acid position 225) the frequency of the most frequent amino acid residue ('R', with frequency of 85%) is greater than 80%. Therefore, in certain preferred embodiments, variants of CYP1 N9 A0 do not comprise variation at residue X₂o4- Furthermore, in certain preferred embodiments, variants of the Al and/or A2 CYPl sequences corresponding to CYP1 N9 A0 do not comprise variation at the respective positions corresponding to residue X₂₀4 of CYP1 N9 A0. By way of example with respect to CYP2 variants, Table 2 sets forth that for CYP2 N13 A0, at residue X₃₄₉ (corresponding to amino acid position 394) the frequency of the most frequent amino acid residue ('F' with frequency of 94%) is greater than 80%. Therefore, in certain preferred embodiments, variants of CYP2 N13 A0 do not comprise variation at residue X₃₄₉. Furthermore, in certain preferred embodiments, variants of the Al and/or A2 CYP1 sequences corresponding to CYP2 N13 A0 do not comprise variation at the respective positions corresponding to position X₃₄₉ of CYP2 13 A0.

The skilled person will readily appreciate the principle of the above examples also applies in the context of CYP4F and CYP4ABXZ sequences. Derivatives

Certain embodiments also relate to derivatives of an isolated protein of the present invention. In a preferred embodiment, the derivative protein has one or more activities of a P450 enzyme as hereinbefore described.

As used herein, "derivative" proteins have been altered, for example by conjugation or complexing with other chemical moieties, by post-translational modification (e.g phosphorylation, acetylation etc), modification of glycosylation (e.g. adding, removing or altering glycosylation) and/or inclusion of additional amino acid sequences as would be understood in the art.

Additional amino acid sequences may include fusion partner amino acid sequences which create a fusion protein. By way of example, fusion partner amino acid sequences may assist in detection and/or purification of the isolated fusion protein. Non-limiting examples include metal-binding (e.g polyhistidine) fusion partners, maltose binding protein (MBP), Protein A, glutathione S-transferase (GST), fluorescent protein sequences (e.g. GFP), epitope tags such as myc, FLAG and haemagglutinin tags.

For the particular purpose of fusion polypeptide purification by affinity chromatography, relevant matrices for affinity chromatography include glutathione-, amylose-, and nickel- or cobalt- conjugated resins respectively. Many such matrices are available in kit form, such as the QIAexpress™ system (Qiagen) useful with (HIS₆) fusion partners and the Pharmacia GST purification system.

Preferably, the fusion partners also have protease cleavage sites, such as for Factor X_a or Thrombin, which allow the relevant protease to partially digest the fusion polypeptide of the invention and thereby liberate the recombinant polypeptide of the invention therefrom. The liberated polypeptide can then be isolated from the fusion partner by subsequent chromatographic separation.

Other derivatives contemplated by the invention include, but are not limited to, modification to amino acid side chains, incorporation of unnatural amino acids and/or their derivatives during peptide, polypeptide or protein synthesis and the use of crosslinkers and other methods which impose conformational constraints on the isolated protein, fragments and variants disclosed herein.

Methods for producing engineered ancestral proteins

In another aspect, the invention provides a method of producing or constructing an isolated protein, said method including the step of producing or constructing an engineered ancestral amino acid sequence of at least a fragment of a P450 protein amino acid sequences from one or more P450 amino acid sequences that are different to the engineered ancestral amino acid sequence.

Suitably, the engineered ancestral P450 protein protein displays or possesses one or more increased or enhanced properties compared to at least one of the one or more P450 protein amino acid sequences that are different to the engineered ancestral amino acid sequence.

Non-limiting examples of the one or more increased or enhanced properties of the protein include thermal stability, stability in solvents (e.g. organic solvents), metabolite production, catalytic versatility, catalytic efficiency (e.g. the efficiency of coupling of product formation to cofactor consumption), ligand binding capacity (e.g. increased or decreased strength of binding; and/or increased or decreased specificity of binding, as desired), substrate specificity (e.g. increased specificity or increased genericity, as desired), enzyme kinetic properties (e.g. increased Vmax, lower K_m), ability to couple to a diversity of proteins (e.g. P450s and/or other electron acceptor proteins), and ability to use a diversity of electron donors (e.g. both NADPH and NADH, or NADH preferentially as an electron donor), although without limitation thereto.

Suitably, the engineered ancestral protein having P450 enzyme activity is distinct from any of a plurality of corresponding "extawi" enzymes encoded by respective genomes of different organisms, such as those proteins used to construct or produce the engineered ancestral protein. In this regard, it will be appreciated by persons skilled in the art that a protein comprising an amino acid sequence comprised by the engineered ancestral protein having P450 or P450 reductase enzyme activity may or may not ever have actually existed until its construction according to the method of the invention.

In some embodiments of the method, the step of producing or constructing an engineered ancestral amino acid sequence of at least a fragment of a P450 protein comprises the use of one or more computational methods for the reconstruction of engineered ancestral DNA and/or amino acid sequences. As will be understood by one skilled in the art, such methods can include "maximum parsimony" methods, "maximum likelihood" methods, and "Bayesian inference" methods. In some embodiments, said one or more computational methods include a "marginal likelihood" method and/or a "joint likelihood" method.

In some embodiments of the method, the construction of a sequence of a hypothetical engineered ancestral protein comprises the use of one or more software tools for the reconstruction of engineered ancestral DNA and/or amino acid sequences. Said software tools may include, although without limitation thereto, FastML (Ashkenazy et al. 2012), Phylobayes 3 (Lartillot et al. 2009) and/or one or more of those listed at http://topicpages.ploscompbiol.0rg/wiki Engineeredancestral_reconstruction#Software, incorporated herein by reference.

According to some embodiments of the method, "evolutionary intermediate sequences" may be calculated or constructed using one or more software tools, wherein said evolutionary intermediate sequences may or may not have ever existed prior to construction according to the method.

In some embodiments of the method, an evolutionary tree is constructed for the engineered ancestral P450 or P450 reductase protein using one or more of the aforementioned computational methods and/or software tools, and amino acid sequences which represent nodes within the evolutionary tree are identified. As used herein, a node" within an evolutionary tree represents a common ancestor of the descendants that share or are linked by the node.

In some embodiments, said sequence which represents a node within the evolutionary tree may be constructed based on the whole tree, and referred to herein as "whole tree" ancestor sequences. As hereinabove described, AO and Al sequences may be referred to as a "whole tree" ancestor sequences. By way of example, SEQ ID NOS:l-23 and SEQ ID NOS:24-46 may be referred to as whole tree CYP1 ancestor sequences.

In other embodiments, said sequence which represents a node within the evolutionary tree may be constructed based on subfamily sequences, and referred to herein as a "subfamily" ancestor sequence. As hereinabove described, A2 sequences may be referred to as subfamily sequences. By way of example, SEQ ID NOS:47-63 may be referred to as subfamily CYP1 ancestor sequences.

In one embodiment, the isolated protein having P450 enzyme activity produced according to the method is an isolated engineered ancestral CYP1 protein as hereinbefore described. In certain particular embodiments, the isolated engineered ancestral CYP1 protein comprises an amino acid sequence set forth in any one of SEQ ID NOS: 1-63

In one embodiment, the isolated protein having P450 enzyme activity produced according to the method is an isolated engineered ancestral CYP2 protein as hereinbefore described. In certain particular embodiments, the isolated engineered ancestral CYP2 protein comprises an amino acid sequence set forth in any one of SEQ ID NOS:64-141.

In one embodiment, the isolated protein having P450 enzyme activity produced according to the method is an isolated engineered ancestral CYP4F protein as hereinbefore described. In certain particular embodiments, the isolated engineered ancestral CYP4F protein comprises an amino acid sequence set forth in any one of SEQ ID NOS:142-151.

In one embodiment, the isolated protein having P450 enzyme activity produced according to the method is an isolated engineered ancestral CYP4ABXZ protein as hereinbefore described. In certain particular embodiments, the isolated engineered ancestral CYP4ABXZ protein comprises an amino acid sequence set forth in any one any one of SEQ ID NOS: 152- 159.

This aspect also relates to a modified engineered ancestral P450 protein produced according to the method of this aspect.

In yet another aspect, the invention provides a method of producing or constructing a modified engineered ancestral P450 protein, said method including the step of introducing one or amino acid substitutions in an amino acid sequence of the engineered ancestral P450 protein to thereby produce or construct the modified engineered ancestral P450 protein.

Non-limiting examples of the one or more improved or enhanced properties of the protein include thermal stability, stability in solvents (e.g. organic solvents), metabolite production, catalytic versatility, catalytic efficiency (e.g the efficiency of coupling of product formation to cofactor consumption), substrate specificity (e.g. increased specificity or increased genericity, as desired) and enzyme kinetic properties (e.g. increased V_max, lower K_m). In certain preferred embodiments, said amino acid substitutions comprise functional or functionally important amino acids comprised by an engineered ancestral P450 protein. In certain embodiments a functional or functionally important amino acid is one which is known or predicted to substantially affect a protein property or function, such as hereinbefore described.

In certain other preferred embodiments, said amino acid substitutions comprise amino acid positions wherein there is low prediction confidence within an engineered ancestral P450 protein sequence constructed using one or more computational methods and/or software tools, such as the computational methods and/or software tools as hereinbefore described.

Said modifications may comprise amino acid positions wherein there is variation amongst a plurality of hypothetical engineered ancestral protein sequences constructed for the P450 enzyme using different software tools and/or computational methods, although without limitation thereto.

In certain other preferred embodiments, said amino acid substitutions comprise amino acid positions wherein there is variation amongst extant and/or evolutionary intermediate sequences used to construct nodes within an evolutionary tree constructed for the hypothetical engineered ancestral P450 protein, as hereinbefore described.

In certain preferred embodiments, the modified engineered ancestral P450 protein is a modified CYP1 protein. In certain embodiments, the modified engineered ancestral CYP1 protein comprises a CYP1 AO sequence with preferred variations as hereinabove described, with reference to Table 1. In certain other embodiments, the modified engineered ancestral CYP1 protein comprises a CYP1 Al or CYP1 A2 sequence with variations corresponding to said preferred CYP1 AO variations, as hereinabove described.

In certain preferred embodiments, the modified engineered ancestral P450 protein is a modified CYP2 protein. In certain embodiments, the modified engineered ancestral CYP2 protein comprises a CYP2 AO sequence with preferred variations as hereinabove described, with reference to Table 2. In certain other embodiments, the modified engineered ancestral CYP2 protein comprises a CYP2 Al or CYP2 A2 sequence with variations corresponding to said preferred CYP2 AO variations, as hereinabove described.

In certain preferred embodiments, the modified engineered ancestral P450 protein is a modified CYP4F protein. In certain embodiments, the modified engineered ancestral CYP4F protein comprises a CYP4F AO sequence with preferred variations as hereinabove described, with reference to Table 3.

In certain preferred embodiments, the modified engineered ancestral P450 protein is a modified CYP4ABXZ protein. In certain embodiments, the modified engineered ancestral CYP4ABXZ protein comprises a CYP4ABXZ AO sequence with preferred variations as hereinabove described, with reference to Table 4. In certain other embodiments, the modified engineered ancestral CYPFABXZ protein comprises a CYP4ABXZ Al sequence with variations corresponding to said preferred CYPFABXZ AO variations, as hereinabove described.

In certain embodiments, an isolated engineered ancestral protein of the invention has enhanced thermal stability compared to one or more corresponding extant animal proteins.

In certain embodiments, thermal stability is the ability of a protein to resist "thermal deactivation". As used herein, "thermal deactivation" refers to the loss of a properly folded state of a protein as a result of exposure to heat, and/or the loss of enzyme activity of a protein as a result of exposure to heat.

A measure of thermal stability may be expressed as a ^XT₅₀ temperature (°C) or "T50" for folded protein, wherein 50% of protein is properly folded after exposure to said temperature for a duration of x minutes. For example, the ¹⁰T₅₀ for CYP4ABXZ N1 is about 69 + 1 (FIG. X). Another measure of thermal stability may be expressed as a ^XT₅₀ temperature (°C) or T50 for enzyme activity, wherein there is 50% of enzyme activity after exposure to said temperature for a duration of x minutes.

Thermal stability may also be measured as the percentage of properly folded protein (%) after exposure to a given temperature (°C) for a given duration (min), and/or the percentage of enzyme activity (%) after exposure to a given temperature (°C) for a given duration (min).

Yet another measure of thermal stability may be "thermal deactivation energy" (E_a) which can be defined as the minimum energy that is required to cause thermal deactivation of a protein.

In one particular embodiment, the isolated engineered ancestral CYP4ABXZ N1 protein of the invention has enhanced thermal stability compared to one or more extant CYP4 proteins, e.g. one or more of the isolated proteins comprising the amino acid sequences of the CYP4A, CYP4X, CYP4Z and CYP4B proteins set out in Figure 13-14.

As will be evident from Figure 12 and the examples herein, isolated CYP4ABXZ N1 displayed substantially greater thermal stability than certain extant animal CYP4 proteins.

It will be further evident from Figure 9 and the examples herein that certain isolated engineered ancestral CYP2 proteins possessed greater thermal stability than certain extant CYP2 proteins.

In certain particular embodiments, an isolated engineered ancestral protein of the invention has enhanced solvent stability compared to one or more of the corresponding extant animal proteins.

One measure of solvent stability may be the ability of a protein to adopt a properly folded state at a given concentration of solvent. Another measure of solvent stability may be the enzyme activity of a protein at a given concentration of solvent.

Preferably, said solvent is an organic solvent including, but not limited to: a polar protic solvent including an alcohol, e.g. ethanol, methanol, and isopropanol; a polar aprotic solvent e.g. dimethyl sulfoxide (DMSO), and acetonitrile; and a non-polar solvent including saturated and unsaturated hydrocarbon molecules and aromatic molecules.

In certain other embodiments, an isolated engineered ancestral protein of the invention has altered binding affinity for one or more ligands as compared to one or more corresponding extant animal proteins. By way of example, ligand binding for certain engineered ancestral CYP2 proteins is set forth in Figure 10.

One measure of ligand binding may be a "dissociation constant" (K_d) in molar units. As will be understood by those skilled in the art, K_d indicates the concentration of ligand at which the binding site on a particular protein is half occupied. Therefore, it will be understood that a lower K_d value indicates a higher binding affinity of a protein for a given ligand.

In some preferred embodiments, said one or more ligands comprise a macrolide (e.g. azithromycin, troleandomycin, clarithromycin, erythromycin, and telithromycin) and/or a benzodiazepine (e.g. 2-keto benzodiazepines such as diazepam, and imidazo benzodiazepines such as midazolam, although without limitation thereto).

In certain other embodiments, the activity of an isolated protein of the invention in a reaction comprising a given substrate produces a different metabolite profile, as compared to the activity of one or more extant animal proteins in a corresponding reaction comprising said substrate.

In certain embodiments, the different metabolite profile may comprise one or more metabolites that are present or absent, and/or a relative increase or decrease in one or more metabolites.

Isolated nucleic acids

Another aspect of the invention provides an isolated nucleic acid that encodes an isolated protein of the invention, inclusive of fragments, variants and derivatives of the isolated protein.

The term "nucleic acid" as used herein designates single-or double-stranded DNA and RNA.

DNA includes genomic DNA and cDNA. RNA includes mRNA, RNA, RNAi, siRNA, cRNA and autocatalytic RNA. Nucleic acids may also be DNA-RNA hybrids. A nucleic acid comprises a nucleotide sequence which typically includes nucleotides that comprise an A, G, C, T or U base. However, nucleotide sequences may include other bases such as inosine, methylycytosine, methylinosine, methyladenosine and/or thiouridine, although without limitation thereto.

A "polynucleotide " is a nucleic acid having eighty (80) or more contiguous nucleotides, while an

"oligonucleotide " has less than eighty (80) contiguous nucleotides.

A "probe" may be a single or double-stranded oligonucleotide or polynucleotide, suitably

21harmaco for the purpose of detecting complementary sequences in Northern or Southern blotting, for example.

A "primer" is usually a single-stranded oligonucleotide, preferably having 15-50 contiguous nucleotides, which is capable of annealing to a complementary nucleic acid "template" and being extended in a template-dependent fashion by the action of a DNA polymerase such as Tag polymerase,

RNA-dependent DNA polymerase or Sequenase™

Another particular aspect of the invention provides a variant of an isolated nucleic acid that encodes an isolated protein, variant, fragment or derivative disclosed herein. In a preferred embodiment, nucleic acid variants share at least 60% or 65%, preferably at least 70% or 75%, more preferably at least 80% or 85%, and even more preferably at least 90% or 95% nucleotide sequence identity with an isolated nucleic acid that encodes one or more of the isolated proteins of the invention.

In yet another embodiment, nucleic acid variants hybridize to isolated nucleic acids of the invention, under at least low stringency conditions, preferably under at least medium stringency conditions and more preferably under high stringency conditions.

"Hybridize and Hybridization" is used herein to denote the pairing of at least partly complementary nucleotide sequences to produce a DNA-DNA, RNA-RNA or DNA-RNA hybrid. Hybrid sequences comprising complementary nucleotide sequences occur through base-pairing between complementary purines and pyrimidines as are well known in the art. In this regard, it will be appreciated that modified purines (for example, inosine, methylinosine and methyladenosine) and modified pyrimidines (thiouridine and methylcytosine) may also engage in base pairing.

"Stringency " as used herein, refers to temperature and ionic strength conditions, and presence or absence of certain organic solvents and/or detergents during hybridisation. The higher the stringency, the higher will be the required level of complementarity between hybridizing nucleotide sequences.

"High stringency conditions " designates those conditions under which only nucleic acid having a high frequency of complementary bases will hybridize.

Reference herein to high stringency conditions include and encompass :- (i) from at least about 31% v/v to at least about 50% v/v formamide and from at least about 0.01 M to at least about 0.15 M salt for hybridisation at 42°C, and at least about 0.01 M to at least about 0.15 M salt for washing at 42°C;

(ii) 1% BSA, 1 mM EDTA, 0.5 M NaHP0₄ (pH 7.2), 7% SDS for hybridization at 65°C, and (a) 0.1 x SSC, 0.1% SDS; or (b) 0.5% BSA, ImM EDTA, 40 mM NaHP0₄ (pH 7.2), 1% SDS for washing at a temperature in excess of 65°C for about one hour; and

(iii) 0.2 x SSC, 0.1% SDS for washing at or above 68°C for about 20 minutes.

In general, washing is carried out at T_m = 69.3 + 0.41 (G + C) % -12°C. In general, the T_m of a duplex DNA decreases by about 1°C with every increase of 1% in the number of mismatched bases.

Notwithstanding the above, stringent conditions are well known in the art, such as described in

Chapters 2.9 and 2.10 of. Ausubel et ah, supra. A skilled addressee will also recognize that various factors can be manipulated to optimize the specificity of the hybridization. Optimization of the stringency of the final washes can serve to ensure a high degree of hybridization.

In other embodiments, isolated nucleic acid variants may be producing using a nucleic acid amplification technique. Suitable nucleic acid amplification techniques are well known to the skilled addressee, and include polymerase chain reaction (PCR); strand displacement amplification (SDA); rolling circle replication (RCR); nucleic acid sequence-based amplification (NASBA), Q-β replicase amplification and helicase-dependent amplification, although without limitation thereto.

As used herein, an "amplification product" refers to a nucleic acid product generated by nucleic acid amplification.

Particularly for analytical purposes, nucleic acid amplification techniques may include quantitative and semi-quantitative techniques such as qPCR, real-time PCR and competitive PCR, as are well known in the art.

Suitably, isolated nucleic acid variants may be producing using nucleic acid amplification techniques using one or more degenerate primers based on, or derived from, a nucleotide sequence of an isolated nucleic acid disclosed herein. By way of example, the degenerate primer(s) may be designed to anneal to one or more nucleotide sequences of a variant nucleic acid to thereby facilitate amplification of the variant nucleic acid, or a fragment thereof.

Genetic constructs Yet another aspect of the invention provides a genetic construct that comprises an isolated nucleic acid or variant as herein described and one or more additional nucleotide sequences.

Suitably, the genetic construct is in the form of, or comprises genetic components of, a plasmid, bacteriophage, a cosmid, a yeast or bacterial artificial chromosome as are well understood in the art.

Genetic constructs may be suitable for maintenance and propagation of the isolated nucleic acid in bacteria or other host cells, for manipulation by recombinant DNA technology and/or expression of the nucleic acid or an encoded protein of the invention.

For the purposes of host cell expression, the genetic construct is an expression construct. Suitably, the expression construct comprises one or more nucleic acid or variants disclosed herein operably linked to one or more additional sequences in an expression vector.

An "expression vector" may be either a self-replicating extra-chromosomal vector such as a plasmid, or a vector that integrates into a host genome.

By "operably linked' is meant that said additional nucleotide sequence(s) is/are positioned relative to the nucleic acid of the invention preferably to initiate, regulate or otherwise control transcription.

In one embodiment, the additional nucleotide sequences are regulatory sequences. Regulatory nucleotide sequences will generally be appropriate for the host cell used for expression. Numerous types of appropriate expression vectors and suitable regulatory sequences are known in the art for a variety of host cells.

Typically, said one or more regulatory nucleotide sequences may include, but are not limited to, promoter sequences, leader or signal sequences, ribosomal binding sites, transcriptional start and termination sequences, translational start and termination sequences, and enhancer or activator sequences.

Constitutive or inducible promoters as known in the art are contemplated by the invention. The promoters may be either naturally occurring promoters, or hybrid promoters that combine elements of more than one promoter.

In another embodiment, the additional nucleotide sequence is a selectable marker gene to allow the selection of transformed host cells. Selectable marker genes are well known in the art and will vary with the host cell used.

The expression construct may also include an additional nucleotide sequence encoding a fusion partner (typically provided by the expression vector) so that the recombinant polypeptide of the invention is expressed as a fusion protein, as hereinbefore described.

Isolated proteins of the invention (inclusive of fragments, derivatives and homologs) may be prepared by any suitable procedure known to those of skill in the art. Preferably, the isolated protein is a recombinant protein.

By way of example only, a recombinant isolated protein of the invention may be produced by a method including the steps of:

(i) preparing an expression construct which comprises an isolated nucleic acid of the invention, operably linked to one or more regulatory nucleotide sequences;

(ii) transfecting or transforming a suitable host cell with the expression construct; (iii) expressing a recombinant protein in said host cell; and (iv) isolating the recombinant protein from said host cell.

Suitable host cells for expression may be prokaryotic or eukaryotic. For example, suitable host cells may be mammalian cells, plant cells, yeast cells, insect cells or bacterial cells. One preferred host cell for expression of an isolated protein according to the invention is a bacterium.

Introduction of genetic constructs into host cells (whether prokaryotic or eukaryotic) is well known in the art, as for example described in CURRENT PROTOCOLS IN MOLECULAR BIOLOGY Eds. Ausubel et al, (John Wiley & Sons, Inc. 1995-2009), in particular Chapters 9 and 16.

The recombinant protein may be conveniently prepared by a person skilled in the art using standard protocols as for example described in Sambrook, et al, MOLECULAR CLONING. A Laboratory Manual (Cold Spring Harbor Press, 1989), in particular Sections 16 and 17; CURRENT PROTOCOLS IN MOLECULAR BIOLOGY Eds. Ausubel et al, (John Wiley & Sons, Inc. 1995-2009), in particular Chapters 10 and 16; and CURRENT PROTOCOLS IN PROTEIN SCIENCE Eds. Coligan et al, (John Wiley & Sons, Inc. 1995-2009), in particular Chapters 1, 5 and 6. Antibodies

Another aspect of the invention provides an antibody or antibody fragment which binds, or has been raised against, an isolated protein disclosed herein.

As used herein an "antibody" is or comprises an immunoglobulin. The term "immunoglobulin" includes any antigen-binding protein product of a mammalian immunoglobulin gene complex, including immunoglobulin isotypes IgA, IgD, IgM, IgG and IgE and antigen-binding fragments thereof. Included in the term "immunoglobulin" are immunoglobulins that are chimeric or humanised or otherwise comprise altered or variant amino acid residues, sequences and/or glycosylation, whether naturally occurring or produced by human intervention (e.g. by recombinant DNA technology).

Antibody fragments include Fab and Fab '2 fragments, diabodies, triabodies and single chain antibody fragments (e.g. scVs), although without limitation thereto. Typically, an antibody comprises respective light chain and heavy chain variable regions that each comprise CDR 1, 2 and 3 amino acid sequences. A preferred antibody fragment comprises at least one light chain variable region CDR and/or at least one heavy chain variable region CDR.

Antibodies and antibody fragments may be polycolonal or preferably monoclonal. Monoclonal antibodies may be produced using the standard method as for example, described in an article by Kohler & Milstein, 1975, Nature 256, 495, or by more recent modifications thereof as for example described in Chapter 2 of Coligan et al, CURRENT PROTOCOLS IN IMMUNOLOGY, by immortalizing spleen or other antibody producing cells derived from a production species which has been inoculated with an isolated protein or a fragment thereof. It will also be appreciated that antibodies may be produced as recombinant synthetic antibodies or antibody fragments by expressing a nucleic acid encoding the antibody or antibody fragment in an appropriate host cell. Recombinant synthetic antibody or antibody fragment heavy and light chains may be co-expressed from different expression vectors in the same host cell or expressed as a single chain antibody in a host cell. Non-limiting examples of recombinant antibody expression and selection techniques are provided in Chapter 17 of Coligan et al, CURRENT PROTOCOLS IN IMMUNOLOGY and Zuberbuhler et al, 2009, Protein Engineering, Design & Selection 22 169.

In some embodiments, the antibody or antibody fragment is labelled.

The label may be selected from a group including a chromogen, a catalyst, biotin, digoxigenin, an enzyme, a fluorophore, a chemiluminescent molecule, a radioisotope, a drug or other chemotherapeutic agent, a magnetic bead and/or a direct visual label.

It will be appreciated that the antibody or antibody fragment may be used for the detection and/or purification of an isolated protein disclosed herein. Methods of use of the isolated protein

Another aspect of the invention relates to a method of performing a chemical reaction, said method including the step of exposing a molecule to one or more isolated proteins disclosed herein to thereby perform a chemical reaction in the molecule.

An aspect of the invention also provides a composition suitable for performing the chemical reaction. The composition suitably comprises one or more buffers, salts, solvents and/or other reagents that facilitate or allow the reaction to proceed. It will be understood that such pH buffers, salts, solvents and/or other reagents are well known in the art and may be selected according to the particular type of chemical reaction.

Suitably, the method includes exposing the molecule to a protein having P450 activity and/or a redox partner for the protein having P450 activity.

In some preferred embodiments, said method includes the step of exposing the molecule to at least one of an isolated engineered ancestral CYP1 protein disclosed herein; an isolated CYP2 protein disclosed herein; an isolated engineered ancestral CYP4F protein disclosed herein; and an isolated engineered ancestral CYP4ABXZ protein disclosed herein.

In preferred embodiments, the redox partner for said isolated engineered CYPl, CYP2, CYP4F, and/or CYP4ABXZ protein comprises a P450 reductase protein as hereinbefore described, e.g. a CPR or NPR protein.

In other embodiments, the redox partner for said CYPl, CYP2, CYP4F, and/or CYP4ABXZ protein comprises any other suitable redox partner(s), which may include, but is not limited to one or more of: cytochrome b and cytochrome b5 reductase; and a ferredoxin (e.g. adrenodoxin) and a ferrodoxin reductase (e.g. adrenodoxin reductase) or flavodoxin reductase.

Particular, non-limiting examples of such chemical reactions include redox reactions, hydroxylation at aromatic and aliphatic centres, epoxidation, N-, 0-, S-dealkylation and N-, and S- oxidation, acyl migration, oxidative dehalogenation, ring expansion, contraction and cleavage, C-C bond cleavage, denitrosation of N-nitrosamines, oxidative ester cleavage, aldehyde scissions (e.g to alkenes and HCOOH), ipso attack on aromatic ring substituents and N- or O-dearylation, reductions of alkyl halides, N-oxides, nitro compounds, inorganic molecules such as S0₂, Cr(VI) or NO, desaturations (e.g. dehydrogenations), one electron oxidations, isomerizations and/or phospholipase D activity (e.g phosphate ester hydrolysis). These reactions may have applications for: the production of fine chemicals (e.g. pharmaceuticals, agrichemicals, fragrances, and dyes); gene therapy; bioremediation; biosensors; diagnostics; plant biotechnology; and/or medicinal chemistry (e.g. drug discovery and pharmacological testing). With particular regard to drug discovery, one embodiment of the invention contemplates using the isolated protein disclosed herein for structural diversification of molecules present in molecular libraries, such as natural product libraries, synthetic combinatorial libraries, and/or rationally designed structure-based libraries, although without limitation thereto.

As will be understood by those skilled in the art, structural diversification may facilitate structure-activity relationship ("SAR") analysis to thereby generate an array of improved lead compounds having one or more improved properties such as: enhanced pharmacodynamics properties; reduced toxicity; enhanced bioavailability; enhanced half-life; enhanced formulation properties; and/or reduced production cost, although without limitation thereto. As will be understood by those skilled in the art, in the aforementioned context a "lead" compound refers to a chemical compound that has pharmacological or biological activity likely to be useful for a given purpose; for example, for therapeutic and/or industrial application, although without limitation thereto; but may still have suboptimal properties for said purpose.

With particular regard to pharmacological testing, one embodiment of the invention contemplates using the isolated protein described herein to metabolize a xenobiotic, for example a drug, to produce metabolites that are produced during human metabolism of said xenobiotic. It is anticipated that said metabolites can be used for purposes including the assessment of toxicity to an animal, for example "general toxicity", "genotoxicity", "embryo-fetal toxicity", as will be understood by those skilled in the art; and "carcinogenicity", although without limitation thereto.

With particular regard to bioremediation, one embodiment of the invention contemplates using the isolated protein to metabolize an environmental pollutant, for example, although without limitation thereto, a hydrocarbon pollutant such as a diesel, a gasoline, or an oil; a pesticide pollutant such as an organochlorine pesticide, an organophosphate pesticide, or a pyrethroid pesticide; and a solvent pollutant such as perchloroethylene (PCE) or trichloroethylene (TCE). It is contemplated that that in some embodiments, the isolated protein is expressed by a microorganism or a plant, thereby allowing said microorganism or plant to metabolize an environmental pollutant, or improving the efficiency with which said microorganism or plant metabolizes an environmental pollutant.

With particular regard to biosensor technology, one embodiment of the invention contemplates using the isolated protein to detect metabolites in a human blood sample, for example, drugs or drug metabolites; and/or food contaminants, such as carbamate or organophosphate pesticide residues, although without limitation thereto.

EXAMPLES

Example 1. Materials

Oligonucleotides and ancestrals gene were synthesized by Life Technologies (Mulgrave, VIC Australia). pCW'/lAlHis/hNPR, pCW71A2His/hNPR, pCW71A5His/hNPR, pCWVlBlHis/hNPR, pCW72A6His/hNPR, pCW72A13His/hNPR, pCW/2BlHis/hNPR, pCW72B6His/hNPR, pCW/2C8_FLHis/hNPR, pCW/2C9_FLHis/hNPR, pCW/2C18_FLHis/hNPR, pCW/2C19_FLHis/hNPR, pCW/2ElHis/hNPR, pCW/2F3¹His/hNPR, pCW/2S!His/hNPR, and pCW74AHHis/hNPR were available via previous studies in this laboratory and others ² \ pCW/hNPR was obtained from Professor F.P. Guengerich (Vanderbilt University, US), and the pGro7 plasmid encoding the GroES/EL molecular chaperone system was obtained from Professor K. Nishihara (HSP Research Institute, Japan)¹².

Restriction endonucleases (REs), Antarctic phosphatase (AnP), and T4 DNA ligase were purchased from New England Biolabs Inc./Genesearch Pty. Ltd. (Arundel, QLD Australia). Oligonucleotides and E. coli strain DH5aF'IQ cells were obtained from Life Technologies (Mulgrave, VIC Australia).

Example 2. CYP1

Method of construction of engineered ancestral CYP1 sequences

Sequences of cytochrome P450 family CYP1 proteins were collected from Uniprot, NCBI and the cytochrome P450-nomenclature homepage (http://drnelson.uthsc.edu/cytochromeP450.html) database. Only sequences that contain the conserved cysteine and proline-rich motif at the N-terminus were included. The sequences were aligned using MAFFT ¹³. The alignment was fine-tuned manually to improve its reliability at gap positions. Phylogenetic relationships of these P450 sequences were reconstructed using the Maximum Likelihood method under the JTT substitution model ¹⁴ with MEGA ¹⁵. The tree was determined by neighbour-joining (BIONJ) ¹⁶. For individual ancestral reconstructions using individual subfamilies of CYP1, two approaches were applied.

First, the deepest common ancestor of the extant sequences within the subfamily in question was inferred using a multiple sequence alignment and a phylogenetic tree generated from only those extant sequences in the subfamily in question. CYP1 ancestral sequences generated using this 'subfamily' approach are set forth in SEQ ID NOS:47-63 (referred to herein as Ά2' ancestral CYP1 sequences). Second, the inferences were obtained from analysis of the entire set of extant sequences within the family in question. CYP1 sequences generated using this 'whole tree' approach are set forth in SEQ ID NOS: l- 23 (referred to herein as 'AO' ancestral CYP1 sequences).

Ancestral prediction for all internal nodes in the tree was performed using an in-house bioinformatic tool (denoted bnkit). Briefly, ancestral states were jointly determined using Maximum Likelihood, given the amino acid states at extant nodes of the phylogenetic tree. To enable the exact inference of ancestral states at the scale of the aforementioned protein families, we made several, standard, assumptions, including that amino acid states are defined by a Markov process. Specifically, we assumed that evolution operates by substitution only, with transition probabilities from the aforementioned evolutionary model. Insertions and deletions were handled prior to inference by pruning the tree for that position in the alignment as determined by Maximum Parsimony ¹⁷. We assume substitutions at each position are independent of one another. We make the Markov assumption that substitution probabilities at a state t depend only on the preceding state (t - 1). Finally, the same Markov process with the same evolutionary rate applies to all positions.

Determining variation in engineered ancestral CYP1 proteins

Specific nodes that were of considered of particular interest (e.g. the last common ancestor of a subfamily) were chosen. For each node, the alignment of its corresponding parents and all 'descendent' sequences were first generated. Based on this alignment, variation at each position within the aligned sequence was identified. With reference to the CYPl AO sequences set forth in SEQ ID NOS: l-23, corresponding to individual nodes of particular interest, variation is presented in Table 1.

Furthermore, for each CYPl AO sequence, residues wherein no variation was present within the alignment were identified. These 'conserved' residues correspond to those residues not listed in Table 1. Additionally, with reference to Table 1, residues at which one amino acid variant was present at 80% or greater frequency within the descendent sequences can be identified. Such residues may be considered

'semi-conserved' residues.

It is hypothesized that it may be beneficial to avoid or minimize variation in such conserved and/or semi-conserved residues, in variant CYPl proteins according to the invention. By way of non- limiting example, such conserved and/or semi-conserved residues may be important for certain functional properties associated with CYPl enzymes, such as herein described.

Construction of expression plasmids for engineered ancestral CYPl proteins

Once ancestral nodes were inferred as above, a codon-optimized nucleotide sequence encoding amino acid of specific nodes was then synthesized by Gene Art (Germany). These sequence correspond to the CYPl Al sequences set forth in SEQ ID NOS:24-46. To produce the CYPl Al sequences the N- termini of the inferred CYPl ancestral sequence (i.e. AO sequences, excluding gaps) was replaced with a sequence encoding the peptide, MAKKTSS. Additionally, a C-terminal hexa-His tag was also added to the coding sequence of the ancestral protein linked to the C-terminal end of the P450 coding sequence by a Ser-Thr linker encoding a Sail site.

The ancestral P450 open reading frames were then subcloned into the pCW expression vector ²⁰ containing the human NADPH-cytochrome P450 reductase (hNPR) sequence using the Gibson Assembly

²¹ , 5' Ndel and 3' Xbal sites. The sequences of the open reading frames in the expression plasmid were verified by automated dideoxy sequencing at the Brisbane Node of the Australian Genome Research

Facility (St. Lucia, Australia).

Example 3. CYP2

Method of construction of engineered ancestral CYP2 sequences

Sequences of cytochrome P450 family CYP2 proteins were collected from Uniprot, NCBI and the cytochrome P450-nomenclature homepage (http://drnelson.uthsc.edu/cytochromeP450.html) database. Only sequences that contain the conserved cysteine and proline-rich motif at the N-terminus were included. The sequences were aligned using MAFFT ¹³. The alignment was fine-tuned manually to improve its reliability at gap positions. Phylogenetic relationships of these P450 sequences were reconstructed using the Maximum Likelihood method under the JTT substitution model ¹⁴ with MEGA¹⁵. The tree was determined by neighbour-joining (BIONJ) ¹⁶. For individual ancestral reconstructions using individual subfamilies of CYP2, two approaches were applied.

First, the deepest common ancestor of the extant sequences within the subfamily in question was inferred using a multiple sequence alignment and a phylogenetic tree generated from only those extant sequences in the subfamily in question. CYP2 ancestral sequences generated using this 'subfamily' approach are set forth in SEQ ID NOS:126-141 (referred to herein as 'Α2' ancestral CYP2 sequences). Second, the inferences were obtained from analysis of the entire set of extant sequences within the family in question. CYP2 sequences generated using this 'whole tree' approach are set forth in SEQ ID NOS:64- 94 (referred to herein as 'AO' ancestral CYP2 sequences).

Determining variation in engineered ancestral CYPl proteins

Specific nodes that were of considered of particular interest (e.g. the last common ancestor of a subfamily) were chosen. For each node, the alignment of its corresponding parents and all 'descendent' sequences were first generated. Based on this alignment, variation at each position within the aligned sequence was identified. With reference to the CYP2 AO sequences set forth in SEQ ID NOS:64-94, corresponding to individual nodes of particular interest, variation is presented in Table 2.

Furthermore, for each CYP2 AO sequence, residues wherein no variation was present within the alignment were identified. These 'conserved' residues correspond to those residues not listed in Table 2. Additionally, with reference to Table 2, residues at which one amino acid variant was present at 80% or greater frequency within the descendent sequences can be identified. Such residues may be considered 'semi-conserved' residues.

It is hypothesized that it may be beneficial to avoid or minimize variation in such conserved and/or semi-conserved residues, in variant CYP2 proteins according to the invention. By way of non- limiting example, such conserved and/or semi-conserved residues may be important for certain functional properties associated with CYP2 enzymes, such as herein described.

Construction of expression plasmids for engineered ancestral CYP2 proteins

Once ancestral nodes were inferred as above, a codon-optimized nucleotide sequence encoding amino acid of specific nodes was then synthesized by Gene Art (Germany). These sequence correspond to the CYP2 Al sequences set forth in SEQ ID NOS:95-125. To produce the CYPl A2 sequences the N- termini of the inferred CYPl ancestral sequence (i.e. AO sequences, excluding gaps) was replaced with a sequence encoding the peptide, MAKKTSS. Additionally, a C-terminal hexa-His tag was added to the coding sequence of the ancestral protein linked to the C-terminal end of the P450 coding sequence by a Ser-Thr linker encoding a Sail site.

The ancestral P450 open reading frames were then subcloned into the pCW expression vector ²⁰ containing the human NADPH-cytochrome P450 reductase (hNPR) sequence using the Gibson Assembly ²¹ , 5' Ndel and 3 ' Xbal sites. The sequences of the open reading frames in the expression plasmid were verified by automated dideoxy sequencing at the Brisbane Node of the Australian Genome Research Facility (St. Lucia, Australia).

Expression and thermostability measurement of the ancestral CYP2 proteins

Recombinant proteins were expressed as described previously²² with minor modifications. Starter cultures (5 mL LB media supplemented with 11.1 mM glucose, 100 μg/mL ampicillin and 20 μg/mL chloramphenicol, in 25 mL flasks) were inoculated from glycerol stocks or freshly transformed colonies and incubated overnight at 37°C, with shaking at 400 rpm. Expression cultures were set up in 100 mL flasks by inoculating 100 - 500 uL of starter culture into 10-50 mL Terrific Broth (TB) ²³ containing 100 μg/mL ampicillin, 20 μg/mL chloramphenicol, lmM thiamine and trace elements ²⁴ (TB expression medium). Cultures were incubated at 25°C with shaking at 180 rpm for an initial 5h. Recombinant protein expression was then induced by adding arabinose (4 mg/mL), δ-aminolaevulinic acid (0.5 mM) and isopropyl- -thiogalactopyranoside (IPTG) (lmM) and the flasks were incubated at 25°C with shaking at 180 rpm for a further 43 h. One or more of recombinant extant CYP2 proteins selected from the group consisting of CYP2A6, CYP2A13, CYP2B1, CYP2B6, CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2E1, CYP2F1, CYP2S 1, CYP4A11, CYPlAl, CYPlAl, CYP1A5 and CYPIBI were expressed in parallel as controls as appropriate.

Cultures were harvested by centrifugation at 3000 x g for 10 min then resuspended in whole cell assay buffer (WCAB: 100 mM potassium phosphate, 6 mM magnesium acetate, 10 mM (+) glucose, pH 7.4). The resuspended enzyme solution was heated at various temperatures (30-75°C) for lh in Bio-Rad MyCycler Thermal Cycler, cooled at 4°C for 5 min and equilibrated at room temperature for 5 min. The residual folded protein was then quantified by Fe(II) CO versus Fe(II) difference spectroscopy ²⁵. Results are set forth in Table 4 and Figures

Characterization of ancestral CYP2 enzyme activity

For comparisons of engineered ancestral CYP2 proteins with the respective extant P450 control forms (as indicated for individual experiments), membrane fractions were isolated from bacteria expressing either an ancestral or an extant protein, with or without hCPR. Recombinant enzymes were expressed in 50 ml cultures, harvested and fractionated according to established procedures ²⁶.

(i) HPLC analysis of steroid hydroxylase activity

Testosterone metabolic analyses were carried out with isolated membrane fractions as described previously using 1 μΜ P450 and 10 - 500 μΜ testosterone for 10 min ²¹. Reactions (250 y ) were quenched by the addition of 25 yL progesterone 1 mM (as internal standard) and metabolites were extracted with 1 ml of ethyl acetate prior to HPLC analysis on a C18 column (4.6 x 150 mm, 5 μΜ,

Agilent Technologies), initially equilibrated in 24% (v/v) acetonitrile:water at a flow rate of 1.5 mL/min.

The following gradient was used for elution of testosterone metabolites: 0 - 5.5 min, 24% acetonitrile; 5.5-12 min, linear gradient to 62% acetonitrile; 12-16 min, 62% acetonitrile; 16-18 min linear gradient to

24% acetonitrile; 18-22 min, 24% acetonitrile. Metabolites were detected by absorbance at 247 nm.

Under these conditions, the major metabolite, 6 -hydroxytestoterone eluted at approximately 7 min.

Products formed were identified by comparison to the previously calibrated retention times of 6β- hydroxytestosterone and other identified testosterone metabolites.

(i) Analysis of drug metabolism by LC-MS^5' Bacterial membranes containing 0.1 μΜ P450 were incubated with the substrates listed as follows, at 10 μΜ: Acetaminophen; Midazolam; Aminopyrine; Nevirapine; Amlodipine; Olanzapine; Amodiaquine; Omeprazole; Atorvastatin; Paclitaxel; Benzbromarone; Pioglitazone; Carbamazepine; Pravastatin; Celecoxib; Procainamide; Chlorzoxazone; Propranolol; Clopidogrel; Ritonavir; Clozapine; Rosiglitazone; Dextromethorphan; Sulfamethoxazole; Diclofenac; Tacrine; Diltiazem; Procainamide; Donepezil; Propranolol; Ethinylestradiol; Ritonavir; Erythromycin; Rosiglitazone; Fluoxetine; Tamoxifen; Flutamide; Ticlopidine; Furosemide; Tienilic acid; Imipramine; Valproic acid; Indomethacin; Valsartan; Levofloxacin; Warfarin (R, S and racemic); Metoprolol; Zafirlukast.

Incubations were prepared in 250 μΐ total volume of 0.1 M potassium phosphate buffer pH 7.4 and initiated by the addition of an NADPH-generating system consisting of 10 mM glucose-6-phosphate, 250 μΜ NADP+, and 0.5 U/ml glucose-6-phosphate dehydrogenase. Reactions were quenched at 0 and 30 mins by the addition of two volumes of ice-cold acetonitrile. Precipitated protein was removed by centrifugation and samples were lyophilized then resuspended in 50 % v/v acetonitrile in water for injection into a Waters ACQUITY UPLC liquid chromatography system coupled to a Waters Synapt HDMS instrument (Waters, Milford, MA, USA) with an electrospray ionisation (ESI) source. Separation was achieved with a 130 A, 1.7 μπι x 2.1 mm x 100 mm Waters ACQUITY UPLC BEH C18 column (Waters, Milford, MA) at a column temperature of 45 °C. Mobile phases consisting of ultra-pure water supplemented with formic acid (0.1% v/v; mobile phase A) and pure acetonitrile (mobile phase B) were employed at a flow rate of 0.5 mL min^"1.

The gradient used was as follows: 0.0-6.0 min (10-70% mobile phase B); 6.0- 6.7 min (70-90% mobile phase B), then a return to the initial mobile phase composition over 0.01 min. The MSE analysis was performed with a Waters Synapt HDMS operating in V-mode positive electrospray ionization (ESI) conditions. A routine method with two scan functions was used, comprising an m/z range of 80-1000, cone voltage of 20 V and scan time of 0.1 s. The trap collision energy (CE) in function 1 was 20 V; in function 2 an energy ramp of 15-45 V was applied, and the transfer cell CE was 12 V. Data were collected in a centroid mode. Leu-enkephalin (250 pg mL^"1) was used as a lock mass (m/z 556.2771) for internal calibration at a flow rate of 0.04 mL min^"1. The MSE data were processed in MetaboLynx 4.1 (Waters, Milford, MA) using the dealkylation tool and mass defect filter and the proposed metabolites were manually reviewed.

Example 4. CYP4F

Method of construction of engineered ancestral CYP4F sequences

Sequences of cytochrome P450 family CYP4F proteins were collected from Uniprot, NCBI and the cytochrome P450-nomenclature homepage (http://drnelson.uthsc.edu/cytochromeP450.html) database. Only sequences that contain the conserved cysteine and proline-rich motif at the N-terminus were included. The sequences were aligned using MAFFT ¹³. The alignment was fine-tuned manually to improve its reliability at gap positions. Phylogenetic relationships of these P450 sequences were reconstructed using the Maximum Likelihood method under the JTT substitution model ¹⁴ with MEGA¹⁵. The tree was determined by neighbour-joining (BIONJ) ¹⁶. For ancestral reconstructions, inferences were obtained from analysis of the entire set of extant sequences within the subfamily (F) in question. Ancestral CYP4F sequences generated using this 'whole tree' approach are set forth in SEQ ID NOS: 142-151 (referred to herein as 'AO' ancestral CYP4F sequences).

Determining variation in engineered ancestral CYP4F proteins

Specific nodes that were of considered of particular interest (e.g. the last common ancestor of a subfamily) were chosen. For each node, the alignment of its corresponding parents and all 'descendent' sequences were first generated. Based on this alignment, variation at each position within the aligned sequence was identified. With reference to the CYP4F AO sequences set forth in SEQ ID NOS: 142-151, corresponding to individual nodes of particular interest, variation is presented in Table 3.

Furthermore, for each CYP4F AO sequence, residues wherein no variation was present within the alignment were identified. These 'conserved' residues correspond to those residues not listed in Table 3. Additionally, with reference to Table 3, residues at which one amino acid variant was present at 80% or greater frequency within the descendent sequences can be identified. Such residues may be considered 'semi-conserved' residues.

It is hypothesized that it may be beneficial to avoid or minimize variation in such conserved and/or semi-conserved residues, in variant CYP4F proteins according to the invention. By way of non- limiting example, such conserved and/or semi-conserved residues may be important for certain functional properties associated with CYP4F enzymes, such as herein described.

Construction of expression plasmids for engineered ancestral CYP4F proteins

Once ancestral nodes were inferred as above, a codon-optimized nucleotide sequence encoding amino acid of specific nodes was then synthesized by GeneArt (Germany). To produce the sequences for expression, the N-termini of the inferred CYP4F ancestral sequences (i.e. AO sequences, excluding gaps) were replaced with a sequence encoding the peptide, MALLLAVFL. Additionally, a C-terminal hexa-His tag was added to the coding sequence of the ancestral protein linked to the C-terminal end of the P450 coding sequence by a Ser-Thr linker encoding a Sail site.

Example 5. CYP4ABXZ

Method of construction of engineered ancestral CYP4F sequences

A diagrammatic overview of the ancestral sequence construction process is shown in Figure 11. Sequences of cytochrome P450 family CYP4ABXZ proteins were collected from Uniprot, NCBI and the cytochrome P450-nomenclature homepage (http://drnelson.uthsc.edu/cytochromeP450.html) database. Only sequences that contain the conserved cysteine and proline-rich motif at the N-terminus were included. The sequences were aligned using MAFFT ¹³. The alignment was fine-tuned manually to improve its reliability at gap positions. Phylogenetic relationships of these P450 sequences were reconstructed using the Maximum Likelihood method under the JTT substitution model ¹⁴ with MEGA¹⁵. The tree was determined by neighbour-joining (BIONJ) ¹⁶.

For ancestral reconstructions, inferences were obtained from analysis of the entire set of extant sequences within the subfamilies (A, B, X, and Z) in question. Ancestral CYP4ABXZ sequences generated using this 'whole tree' approach are set forth in SEQ ID NOS: 152-155 (referred to herein as 'AO' ancestral CYP4ABXZ sequences).

Determining variation in engineered ancestral CYP4F proteins

Specific nodes that were of considered of particular interest (e.g. the last common ancestor of a subfamily) were chosen. For each node, the alignment of its corresponding parents and all 'descendent' sequences were first generated. Based on this alignment, variation at each position within the aligned sequence was identified. With reference to the CYP4ABXZ AO sequences set forth in SEQ ID NOS: 152- 155, corresponding to individual nodes of particular interest, variation is presented in Table 4.

Furthermore, for each CYP4ABXZ AO sequence, residues wherein no variation was present within the alignment were identified. These 'conserved' residues correspond to those residues not listed in Table 4. Additionally, with reference to Table 4, residues at which one amino acid variant was present at 80% or greater frequency within the descendent sequences can be identified. Such residues may be considered 'semi-conserved' residues. It is hypothesized that it may be beneficial to avoid or minimize variation in such conserved and/or semi-conserved residues, in variant CYP4ABXZ proteins according to the invention. By way of non-limiting example, such conserved and/or semi-conserved residues may be important for certain functional properties associated with CYP4ABXZ enzymes, such as herein described.

Construction of expression plasmids for engineered ancestral CYP4F proteins

Once ancestral nodes were inferred as above, a codon-optimized nucleotide sequence encoding amino acid of specific nodes was then synthesized by GeneArt (Germany). To produce the sequences for expression, the N-termini of the inferred CYP4ABXZ ancestral sequences (i.e. AO sequences, excluding gaps) were replaced with a sequence encoding the peptide, MALLLAVFL. Additionally, a C-terminal hexa-His tag was added to the coding sequence of the ancestral protein linked to the C-terminal end of the P450 coding sequence by a Ser-Thr linker encoding a Sail site.

Thermostability Measurement of CYPABXZJV2

Enzyme preparations were heated in a 96-well plate at various temperatures (30-80°C) for either 10 or 60 minutes using a Bio-Rad MyCycler thermal cycler, then incubated at 4°C for 5 minutes and room temperature (RT) for 5 minutes. The residual concentration of intact P450 protein was quantified and compared to an unheated control. ⁿT₅₀ values, i.e. the temperatures at which 50% residual enzymatic activity remained after n minutes, were calculated using the equation for sigmoidal melting in Graphpad Prism. Results are set forth in Figure 12. Throughout the specification, the aim has been to describe the preferred embodiments of the invention without limiting the invention to any one embodiment or specific collection of features. Various changes and modifications may be made to the embodiments described and illustrated without departing from the present invention.

The disclosure of each patent and scientific document, computer program and algorithm referred to in this specification is incorporated by reference in its entirety.

TABLES

Table 1. Variable residues Xi - X_n, and amino acid variation at each residue, of engineered ancestral CYP1 sequences corresponding to nodes (i) - (xxiv). For each of the ancestral sequences corresponding to nodes (i) - (xxiv), variable residues Xi - X_n are given in sequential order. For example, for (i) CYP1 N9, 476 variable residues are given: Xi - X₄₇₆. For each variable residue, the format of the data is as follows: [amino acid position]: [first amino acid variant] [percent frequency of first amino acid variant] ... [last amino acid variant] [percent frequency of last amino acid variant]. Position is given relative to the corresponding AO CYP1 sequence, as described herein. Frequency is relative to all sequences used to construct the AO ancestral node sequence. Note that '-' represents a 'gap' or amino acid deletion. By way of example, X₅ of (i) is given as 5:-71Ll 1M08A03P01T01, which sets forth that:

the amino acid position of the variant relative to the alignment to CYP1 N9 A0 is '5'; the first amino acid variant is a deletion;

the frequency of the first amino acid variant relative to all sequences used to construct CYPl_N9_A0 is 71%;

the second amino acid variant is 'L';

the frequency of the second amino acid variant is 11%;

the third amino acid variant is 'M';

the frequency of the third amino acid variant is 8%;

the fourth amino acid variant is 'A' ;

the frequency of the fourth amino acid variant is 3%;

the fifth amino acid variant is 'P' ;

the frequency of the fifth amino acid variant is 1%;

the last amino acid variant is 'T' ;

the frequency of the last amino acid variant is 1%

Only amino acid variants with frequency of 1% of greater are listed. Where the combined frequency of all listed amino acid variants is less than 100%, this is due to the presence of one or more additional variants with frequency of less than 1%. ) N9

:-87M 12 2:-86A10G01 3:-85Tll 4:-77S09M08G01 5:-71LllM08A03P01T01 6:-0S10L02A02N02D02G01K01Q01T01 7:-53M20P07A05L03l02S02V01 8:-50D16AllM06V05E02N01G01L01:-93T03 10:-94E04 11:-94F05 12:-94G05 13:-94V04 14:-94K05 15:-94G04 16:-98S01 17:-8L15D08S06M04F03A03G02V02E01 18:-41M 17S16P08T03A02V02L02H01 19:-0I 15L11V08A04W04M03Q02S02P02R01F01 20:-32L23M08P07l05Q04F04V03A02E02Y01S01D01 21:-2P21G11L07S06R05I04E03D01K01M01A01 22:-27F18S13LllE07l06M04Q03N02V01 23:-6P15S11I 11L07W05A04N03Q03D03G01V01F01 24:-20G 19L19l l0S08V06A02T02M02R01P01K01Q015:S30P21-18A11G06I03L02F02 26:I22V22-10T09F07Q07S06L04A04M03 27:S55Q11-8T06V05L03P02M02A01 28:A38V19Q17-05P04R04L02H01T01I01S01 29:T51S22P06-05G04A02M01N01 30:E66T09A06-05V02L02S01M01D01 31:L51V20S09-04G04I03F02A01 32:L77T07V06-04I01

33:L52V17A08I07T06-04S01 34:A57S14L11V05-04F02C02T01 35:L30S27A13M08F05V05-04I03T01 36:A37T15V15S12I08-04C02L01F01 37:V34I25T18L06F05-04A03 38:F47L35V06-04I02M02A01

39:C59A12V09F06-04L02T01 40:L55A14I07C05-04V03M03S02T01F01 41:V70L13I05-04M02G01T01 42:F43H18Y15L10E06-03 43:L36W29V13A07M06-03I02 44:V32L17G12I09C06F06A04W03-03T01R01 45:V28L23I19Q11R03-03M03K02T01F01 46:R44W22K13Q12-02L01 47:A28L21S16V08F04T04- 03G03Y02H01R01I01 48:L33W16F14R13S07-02M02Q02T02K01 49:R52Q20N07H05K03G03-02S01M01 50:Q28P24T14S08L07R05N03-02K01W01 51:R41K11Q11H10E10-04W03P02G01 52:V38I20R12- 12L07A01S01Q01D01 53:P61-15R14G04 54:K43-15E13Q13R06P01G01A01T01 55:G61-14P09K07L02R02 56:L60G07K06R04Q04A03W02T01-01H01V01F01 57:K47R20S12P04V03Q03L02-01

58:S46R25A08Q04N03G02K01T01P01E01 59:P68L30 61:G95E04 63:W35F27R17K12T02L01

64:G42P25A20S10 65:W58L18Y13F08 67:L51I30V14F02 68:I60L28V11 70:N74H23S01 71:V46A29L12M08I02 72:L69A17M07P01 73:E31T28Q26A07S03 74:L75V17M06I01 75:G83R12H01

76:K44S12Q11N08D06R05P05E02A01 77:N35A17D12M06H06K06S05T02Q02R02 78:P85T06S03A02I01 79:H84Y14 80:L86I08V04 81:S36A29T16V09Y07 82:L66F32 83:T47S25A19M05I01 84:R57K13A11E09Q05 85:L58M41 86:S60A26R09V01G01 87:Q42K29R18E04A01L01 88:R48K35Q09T02C01 89:Y96F02

91:D78N10H03P02S01 92:V97I02 93:F47L26M18Y07 94:Q77E13L06K01 95:I78V14L04M01

96:R60Q19K12H05T01 97:I59L38 99:S42M20T16C14N02R01 100:R38T28C11V06S06L02W02

101:P81D07T04N01R01A01 102:V91I08 103:V61L36 105:L92V06 106:S62N35G01 108:L46E15S07D06M05- 05N04Y03G01 109:D46E26R13S03N02A01Q01 110:T63A24M05V03S02 111:I75V22L01 112:R67K24H07 113:Q88E06K01H01 114:A93V06 116:V69I20L08T01 117:K44R32Q20 118:Q81H07D05K03 119:G88S08A03 120:D35E34A11T06S03L01V01P01I01N01 121:D57E18A11H05N01T01I01V01 123:A49K29M15S05 124:G86D11S01 127:D69N13P10S02R01E01 128:L61F32M05 129:Y54A12H12V05T05P04F02 130:S87T11 131:F96S02 132:R32T26Q22S11K04H01 133:F32L29V12Y10H06M05A02N01 134:I55V37L04F01

135:S46T19A16N12G02 136:D44G22N22E08 138:Q41K30R17D02T02H01E01N01 140:L54M41F01I01 141:A46T39S13 143:S52G20N20T05 144:P38-28T19V05E02S01 145:D60N14H04T03Q03K03S02G02P01R01 146:S44Y34Q11V03K02C01T01 147:G55S25A13T02V01 148:E39P30G15K05D05Q02

149:V57S09Q06W05R05H03L03A03I02 151:K46A28R21L01 152:A67L12V09T04M03 153:R62H24Q12 154:R89K09 155:K53R46 156:L64I14A11V07 157:A97C01 158:Q59H13Y11S05K02M02L02

159:N48S40D03G02K02A01T01 160:A68T25G02S01M01 161:L75V10M09I04 162:R53K35N09

163:S38T31A21M03N03 164:F98L01 165:S93A05 166:T34I32S10V07K04N03Q02M01L01

167:A54L13R11G08S05T01V01I01 168:S30E20N14P14Q11A01H01K01D01 169:D28S26P18G13A08 170:P45Q13R13K10T08S03H01A01 171:T43A22S20G04N04-01L01 172:S55R14K13P10A02

173:S37E14R12K11T09A04Q03G01L01V01 174:S41-29Y15C10A01 175:S55-28T14 176:C70-29

177:L29Y29V16A11T06M02I02 178:L84F14 180:E66Q11G10D02H01K01N01M01R01 181:H94Q03

182:V75I18L02A01 183:S45L17C13V08T07I03R01A01 184:K57G11A10S06E05C02T01D01N01

186:A74G09V09F02T02I01S01 187:E41R17D10S08T04K02M02L02N02Q02A02 188:Y38E32A14H05V03D02 189:L97M02 190:V54I30L14 191:S19K18T14A10E08G08R08Q06N02H01 192:K37L17V14R12Q08E03I02T01A01 193:F52L44I02 194:Q29L28V18N06T03A02S02H02R01M01K01 195:E35R20Q17K08T06S04N02A01D01G01 196:L48V17G 11Q07K06R04 197:M58S23T11C01G01-01A01 198:A44E15K13S11D05R03T02Q01 199:E32G28A11K10D05T03V02Q01R01S01

200:G23E15V13P09K08D08N06A04S03Q03 201:G53K15A13Q09R04 202:S28H18F14R13Y11G04C03K02A01 203:F82L13I02V01 204:D78N08E05Q05H01 205:P94L04 206:Y36F16R13A08N04T04V03M03S02H01G01 207:R46N12P09Q08H06S05T04G02K01D01 208:Y41H 14L09Q09E08P04A04S02V01N01

209:V30I27L26T09F03M01 210:V75T15L04I03 211:V80C06L03E02A01I01T01S01 212:S69A28T01

213:V86A07T05 214:A96T02V01 215:N97K01 216:V92I06 217:I67M23V09 218:C63S22G 14 219:A82G 15 220:M49L20V17I 11 224:K39R26Q18C11N01H01 225:R85H 11N02 226:Y85F13

227:D44S24P13G07N04E03T01 228:H78Q10Y06E01R01 229:D47N20S15E05H03G02K01 230:D75S13N05H04 231:Q44E22A13K05D03L03P03V01G01 233:L47F39M 12 234:L70R16V05Q03T01

235:S45E11N08T07R06G05Q05A02D02K02 236:L60I25V12 237:V67L21I09

238:N43K16S13G 11H02D02E02T02Q01R01 239:L37R14H 12N07S06T06V04I03M02K01

240:N41S40T06V04G01L01A01M01 241:D34N28E22H 10K01 242:E57D17Q11K08N02R01 243:F91L05V02 244:G60V19L08T07S01N01 245:E37R17Q17K14D10N01 246:V41T36A10I03S02N02L01

247:V47A35T08S06F02 248:G47A30S19T02 249:S55A40V01 250:G92A06 251:N64S31Y02H01

252:P64L26I05A01 253:A50V45S01 255:F70V26A01 256:I51F18M 17L12 258:I34W29V16C05L05F04A03 259:L90F07M01 260:Q49R44K04 261:Y71R09S06F05L04I01 262:L65F31M02 264:N62S30L05

265:P51R22S09T06K05Q03A01 266:-70V22l05 267:-70R23K05 268:-70T19S08A01

269:A34T27S12I10V06L02M01G01 270:M32L30F22Y06I06V01 271:K25Q18R18D14N10E06S01T01A01 272:A16K14R14N12L11E09T03S03I02Q02D02V02F01G01 273:F89P05M01Y01L01

274:K57E09R08V07M06Q04L03I02 275:D38Q14E12N09A07S06K03T02R01 276:L42F29I22V03Y01

277:N90Y06I02 278:R30Q20K17E09A06D05N03H02T01L01 279:R46K15E13N11A05D04S01

280:F86L09M02I01 281:N25S18Y16L14F07V05T03I01G01H01

282:N17S15Q09T07R07A07G06D05I04H03V03K03E02L02F01 283:F95L02Y01 284:V44L22I 17M 13T01 285:Q56L11K08R07A06E02H02 286:K57D22L05R03N02G01S01Q01A01 287:I33K29M 11T09H05L05N01R01 288:V76F14I07L01 289:Q26K25L13S08V07E04T03R03M01N01 290:E70R10Q08D06K02

292:Y61R25L05I02C01 293:E26K18T13Q12A09R08S03D03N01 294:T55S27D13 295:F58Y20L14I03M01 296:D53E19R10N08Q03V01K01 297:K64P23E05S04 298:G30N24D23E11S06

299:H29N24A13S12V08T04C02R01 300:I64A11V10T08M01G01 301:-85P14 302:R85Q14 304:I70M26V02 305:T73M 14S07V01 306:D85G13S01 307:A52S47 308:L71F21I06 309:I84F10L03

310:E27K15D14L10N08G04V04S03A03R02Q01H01 311:H53S10V08Q07A06L05T03I02

312:C53S12A11I07L06N02Q02V01Y01 313:E40Q28D07G06H05L04K02R01N01

314:D35E22K21N06H05Q04R01T01 315:K39R20G 13E05N04S04A02Q02I02-01L01

316:K37S15R10A10E05Y04-03Q03P02L01D01N01T01 317:L30A16V12-11R09D04T03E03S02G01

318:D34A14G 13-11E10K03T03N02S01V01 319:E38-13S11G09T08A06D05N02K01 320:N40-28S11D07K06P02 321:-87G07D02 322:-87D09E02 323:-37A28S15G 10T04V01 324:N36G27T07A05D05R03-03H03S02E01 325:I22V20A15G09S06T05D04P04L03N02H01R01 326:Q42L13R12T06G05P04S03H03A01K01E01V01 327:L57I20M09V07S01P01 328:S46P21D13T05N04E02G02 329:D40K19Q10L09N08E03H02V02M01 330:E69D16K04S03G01Q01 331:K59Y14E05N05F04H04Q03D01 332:I62V30T04A01 333:V49I22P16E07T01 334:N36G19S18A15P04H02T01 335:T36I32L20V09 336:V86I11L01M01

337:N49T20L09S06G05I02M02A01F01 339:L59I40 340:F92I06 341:G98A01 343:G78S20 344:F70Q26L02 345:D92E06 346:T97P01 347:V51I24L20M02 348:S50T44A03I02 349:T96A02 350:A82C05G05F02V01 351:L66I28M03 352:S59Q25Y05L03H02T02 354:S61L14I 13A05C02M01V01 355:L65V16I 10F06

356:M46L35I09V06 357:Y69L22F03I03V01 358:L80F12V04A01 359:V67I 12T10A07

360:T36R18A14K14L06H03S02Y02M01 361:Y60N17H06K04S04F02R01 363:E46D25N08R07K03S03H01G01 364:I60V32M03L01 365:Q97E02 366:K28R20A20E14T06V02Q02D01S01 367:K62R35 368:I55L30V13M01 369:Q76H13Y05F03 370:E55Q17A12K09D01R01 371:E91L04Q02 372:L67I23V07M02 373:D84K11E01 374:T25Q25E13R12K09G05D04A01 375:V57T15N11K09I02H01Q01 376:I54V43T01 377:G94D04

378:R65L14Q07M04S02K01P01 379:D33E23A18S07-06N04G01I01 380:R94K05

381:L30R29Q12T11P04S02W02M02K01 383:R58C15S11T04L03V02Q02 384:L64I 11F10M07A02V01T01 385:S58E23D08A03G02T01 387:R65Q20K13 388:P52G 11S11K06L04N04A03T02Q01

389:Q30N26H09T08M05S04I04K03R02D01 390:L96M03 391:P91A06H01 392:Y82L09F06

393:L38T26V17M 13103 394:E70M 18D07L01 395:A97S02 396:F97V01 397:I83L15 398:L59Y29N05S01 400:T31I 19M 15V14A08L05S04 401:F67M27L02Y01 403:H68F27Y03 404:S71T21A06 406:F94Y04L01 407:V52L39I04M02 409:F70V21L06 411:I98L01 414:S52C31A14 415:T97S01 416:T87S04I03V02

417:R33K30A14T09S07V01 418:D78N12A05S02 419:T84V07A06I01 420:S44T25V14A03F03I02N02 421:L72I14V12 422:N62L11M08K05E04S04G01 423:G97S02 424:Y61F32L06 425:Y45F27H18T03P01L01 428:K93R04Q01 429:D53G 17E12N09K05 430:T61R29C03L03H01 431:C69V29 432:V81I 14T04 434:I51V48 436:Q92M06 437:W90Y08 438:Q69S29H01 439:V70I26L01 443:P52E24Q17

444:K38E17T10V09A07L05Q03S03D02 445:L56K22I08V04Q03M02 447:K37G20P10D08S07E07V02Q02 448:D63N23E07H03Q01 450:S47E20F08H06D05N04L03Q01 451:E23S14T14D11V10A07L07K03N02I01 453:R32N30D24L02S02Q01K01I01 455:E57D14A11S07T03Q02G01 458:L97I01 459:D30T28N22S14G01 460:A40E20K12P11D03Q02S02T02L02 461:D52N19E08S06A04T01G01K01Q01H01 462:G91R03N01D01 463:-52T41S02 464:E33A18T17F10S05L02K02Q02G01D01M01 465:I45L31V21 466:N78D16S04 467:K87R11 468:D27T19A13V09L09S06M03E03N02P01I01 469:L61E23D08A01K01 470:S36T20G20A14V06I01 471:E63S20D07N05 472:K70S18N07R02 473:V94M03I02 474:M52L29I 14V01T01

475:I47L24V14T05A04M01S01 477:G70S29 478:L45M33V12T04A03 480:K89I06R03 482:R75K24

484:I86L11V01 486:E89D08 487:E20V20T18S08Q08D07A04P02I02N02G01 488:I55L31V07P01F01M01 489:A58S21G19 490:R57K41 491:W33M 17N17L12V08S03I01A01 492:E72Q24L02 493:V58L20I 16M04 494:F93Y06 495:L89I06V02M01 497165116T10F02S01V01 498:A61S20T17 499:I63T23L05V04A01 500:L80I08M05V05 501:L66A15I09V07 502:Q66H33 503:Q71R14K08E02N01 504:L56C28V10I01M01 505:E44N 16K09H08S06R06Q02T02D01 506:F85L07I06 507:S43E11K11T08R07H05Q03Y02N01L01 508:V36A21K10S07L06N04T03E02I02P01G01 509:P21N18C14S09L06R05D05M05T02K02V02I01-01H01 510:P76D08A04Q04-01L01S01 511:G66D08N07S04A03E03R02K01

512:E39V23Q09K07A05T03H02R02D01G01M01S01 513:K40P25E10D07Q04M02T02S01R01A01 514:V46L29S09P08A02F01 515:D70K12T08S04N02 516:M52L37I06 517:T67D18S05N05E01

518:P68F14C07Y05T01S01 519:I24E15S15T14Q09N06L06V02D02H01 520:Y97F02 523:T84S06A05V02 524:M63L20I 15 525:K97R02 526:H49P38Y07-03 527:K51A19L07P05-04H03T02R01N01

528:R46P12S12K05H05-04A03D03C02N01T01 529:C60F20Y14-04 530:-54E40K03Q01

531:H45K12Q07T05S05R05C04-04Y02L01A01V01 532:F30l23V19L19-04 533:Q47N11R09S06T05A05- 04K03H03G01 534:V44A37I06-05M03T02 535:K23T23R16S11Q09-05E03H02A01W01 536:L45M 13P11Q09- 05K05V03A01R01 537:R92-05

(ii) N13

1:-98M01 2:-96A01M01 3:-95G01T01 4:-92M05L01 5:-88M05P01T01 6:-88N01K01L01E01 7:- 67M21A04I01S01 8:-62A16M08V07G01l01 17:-60L21M06F04P01G01 18:-50M24S14A02L02T01V01W01 19:- 49I 15V11A05L05M04S02P01Q01F01 20:-38L31M llF06V04A03Y01l01 21:- 37P21G14S06I05L04E02M02K01V01 22:-30F24L14S10Q05l05M03E01 23:-

29I 15S12P12L06Q04A03D03N03G01V01F01 24:G27-21I 13L10V08S05T03M03A02K01Y01 25:P28S26- 18A14I05F02L01E01 26:I30V30F10-07L06M04Q03T02A01S01 27:S77T09-05M03L02 28:A53V27P06L04- 02T01I01S01 29:T56S26G06M02-02E01L01 30:E93D01S01-01 31:L37V29S13G06I04F04A01-01 32:L83T10- 01F01 33:L55V23I 10T06-01 34:A79S08V07T01-01 35:S37A19L19M 10I04V03T02-01

36:A50T16V12I 10C02F02-02L01 37:I33V30T25A04-01L01 38:F65L13V09I04M03A01-01 39:C83V08T01- 01A01S01 40:L76I09V04M04-01T01 41:V79I07L04G02-01T01M01 42:F60Y21L14-01 43:W40L37M08V07I02- 01 44:V45L23I 12F07A05T02-01 45:V39I27L22M04T02F01-01 46:R59K19Q16

47:A39S22F06T05L05G03Y03V02H02R01-01Q01 48:L28W23F19S11R04M03T02K01-01

49:R49Q26H07K04G03S01M01N01W01 50:P33Q21T19S11N04R02K01-01V01

51:R32Q15K15H 14E14W02P01A01 52:V53I29-10L02D01A01 53:P86G06R01-01H01

54:K58E18R06Q04A02G02P02T01-01 55:G85K10D01 56:L84Q06R01F01H01 57:K65R15V05Q04P03L01S01 58:S58R22Q05N04K02P02T01 59:P70L28 61:G93E06 63:W49R23K17T03M01S01 64:G59P23S13A03 65:W42L25Y19F11 67:L48I42V04F03M01 68:I55L39V04 70:N64H33S01 71:V63L17M 12I03A01 72:L95F01I01 73:E42T39Q14S01D01 74:L83V13M02 75:G76R18H01S01 76:K61S12D08N05R03E03A01

77:N48D16H09K08S06Q03R03T01 78:P87T09I01M01 79:H77Y21 80:L93V04 81:A39S35V13T11 82:L92F06 83:T60S25M06A05I01 84:R50A15E13K10Q07S01 85:L51M48 86:S84R13G01 87:Q54K28E06R05A01L01 88:R49K31Q13C01H01T01 89:Y95F03 91:D86H04P03S02N01 92:V96I02 93:L36F36M26 94:Q68E18L08K02 95:I74V20L03M01 96:R55Q24K10H06T01 97:I83L13M01 99:S36M28T22C10 100:R44T40V09L03K01 101:P96T01 103:L51V46I01 105:L90V09 106:S87N 10G01 108:L65S10M08N06Y05I01 109:D58E35N03 110:T87M07V03 111:I65V32L02 112:R68K30 113:Q95K01H01 114:A90V08 116:V68I 18L09T01

117:K53R42Q03 118:Q89D08 119:G95A03 120:D50E47N01 121:D72E14H06N01A01S01 123:K41A30M21S06 124:G97S01 127:D87N09E01 128:L86M08F04 129:Y76H 16F03P01 130:S82T16 131:F94S03

132:T36R25S16Q13K04H01 133:F38L36Y11H08A02 134:I66V24L06F02 135:T27S26A21N18G03

136:D61N23E11G01 138:Q57K35T02H01E01 140:L52M44F02 141:T46A33S19 143:S70N26G02

144:P54T27V08E03S02 145:D84N09K03E01 146:S60Q16Y13K03C01T01 147:G77A18V02 148:P41E35G20D01 149:V80S10A03I03 151:A40R28K26L01V01 152:A82L12T02 153:R85H12 154:R86K12 155:K58R41 156:L87I 11 157:A96C02 158:Q65Y13S07K03M03L03H01 159:N68S23D05K03 160:A95G03 162:K50R34N13

163:S53T42N02 164:F97L01 165:S92A06 166:I45T19V10K06S05N04Q02L01M01 167:A65L18S07T02V01I01 168:S41E28P20A02D01K01Q01 169:D39S27G 18A10P02N01 170:P63K14T11S04Q02R01

171:T39A30S14N05G04-02L01D01 172:S77P14A03L01 173:S52E19T12A06L02G02V01

174:S57Y21C15A02T01 175:S78T20 177:Y40L35V10A07M03 178:L97V01 180:E93D03M01 181:H96Q01 182:V78I19 183:S63C19T07I03R01 184:K80E07A04T02Q01N01R01 186:A74G 12V08T02

187:E58D14S11L03N03A02K01Q01 188:Y53A17E11H08V04C01 189:L96M02 190:V47I38L13

191:S26K24T21G10E05R04N02Q02 192:K51R16Q11V10E04T01I01 193:F54L42I03

194:Q42L23N08T04V03A03H03S03R02M01K01 195:E48Q21T08K07S05N03D02 196:L61V24Q09-01R01 197:M82T07S05-01A01 198:A37E20K15S12D07T02-01 199:E36G22A14K14T04V03R01S01

200:E19V17P13K12D10N09A06S05Q01G01T01 201:G74K19Q02E01 202:S40H23R18G05C03K03A02 203:F96I01L01 204:D87E07N04 205:P93L05 206:Y50F23R07N06V04T01A01S01

207:R58N17S07Q05G03K02D01I01 208:Y50H20Q13A06P02S01L01E01V01 209:V41I35L20M02T01

210:V84T10L03M01 211:V72C08L04E02A02T02I02S01G01M01 212:S89A08T01 214:A94T03V01 215:N96K02 216:V98I01 217:I87V12 218:C77G 19S02 219:A76G22 220:M69I 15L13 224:K42R30Q25N01H01

225:R80H15N03 226:Y79F19 227:D62P18S11E04N02 228:H78Q14E02R02Y01 229:D36N27S21H05E03K02 230:D65S19N08H06 231:Q61E25K07D04 233:L66M 17F15 234:L90V08I01 235:S63N12R07G06T04K03D02 236:L54I35V08F01 237:V84I13L02 238:N61K20D03E03T02H02R01S01M01

239:L53N10S09T09V06I04M03E01 240:S56N28T08G02A01 241:N39D29H14E11K01S01

242:E66D24Q04N03K01 243:F88L07V03 244:G52V27L11T02N01S01M01A01 245:E44K16Q15D14R04N02A01 246:V58A13T12I05S03N03L01 247:A49V26T11S08F03 248:A41G27S26T03 249:S77A16V01N01T01G01 250:G89A08 251:N90S03Y03H01 252:P90L05A02 253:A71V24S01T01 256:I72F26L01

258:I48V23C08L07F05A05 259:L87F10M01 260:R61Q33K04 261:Y88F07I01L01 262:L92F03M03I01 264:N48S41L08 265:P31R30S12T09K07Q04A01 269:A34T33S17I07G02N01K01 270:M46L43I08V01 271:K32Q22D15N14R05E03S02T02A01 272:K20R20A20L16T05I04V03N02S02F01G01

273:F85P08M02Y01L01 274:K61V10M09R08L05I03Q01 275:D50E14A09N08S08Q04R01T01K01

276:F41I27L25V02Y01 277:N86Y08I03 278:Q25K21R16A08D08E07N04H02T01 279:R65K21A06N01Q01Y01 280:F81L13M03I01 281:N35L20Y16V08S07T03I02M01H01

282:S19Q13R10T08N07A05H05I05K04L04V04G03F02E02D02 283:F94L04 284:V34L31M 18I 13T01

285:Q76A08R04E03K03H01 286:K80L06R05N02D01Q01 287:I46M 16T13H07L07N02R02C01 288:V87I 10L01 289:Q36K36S10T04E03R03N01 290:E88D09 292:Y86L07I03 293:T18K18Q17E12A12R10D03S02N01 294:T62D19S15K01 295:F73Y26 296:D68E23N07 297:K90E07 298:N33D30G22E09S03

299:H40N34S16C03R02Y01 300:I85V12L01M01 302:R80Q20 304:I96V03 305:T94V02I01 306:D80G18S01 307:S66A33 309:I79F15L04 310:E38K21D20N08A04G02Q01S01 311:H74Q10T04L04V02I01

312:C75S16N03Y01 313:E40Q38H07L06K03 314:D49E27K13N08 315:K47R28G09N06S04D01

316:K48S20R10Y06Q04P03E01N01H01 317:L42V17R13A10E02D02S01T01M01Q01-01G01I01

318:D48A19E10G09T03N03S01V01 319:E54S12A08T07-03G03N02D01K01 320:N56-20D10K09E01S01 323:A38-33S18T06V01 324:N51G 15T10A08H04R03S03 325:I31V24G 12A07T06D05S02L02P01R01M01 326:Q58L16T07P05H04A01V01 327:L47I28M 13V09P01 328:S61P28N06L01 329:D56Q13N11K09H04E02 330:E74D08K05S04Q02G01 331:K83E07Q04N01S01 332:I88V07T04 333:V67I31 334:N51G21S19H04T02 335:I44L28T13V13 336:V93I06 337:N68L13S05I03M03F01T01Y01 339:L73I26 341:G98A01 345:D90E09 346:T95P02S01 347:V66I33 348:T61S30A04I03 349:T95A03 350:A81C08G07T01 351:L59I39

352:S83Y07Q03T02L01 354:S86A07C03G01 355:L66V19F09I03 356:M65L24V06I01G01 357:Y97L02 358:L89V06A01 359:V77I 12A08 360:T51A19L08H04K03S03Y03M01 361:Y51N24K06S06H04F02R01W01 363:E47D20R11N10S04K03G01H01 364:I73V22M01 365:Q96E03 366:K36R27E20A06T02D02V01 367:K73R24 368:I76L21V01 369:Q71H15Y08F04 370:E62Q20K11R01A01D01 372:L76I21M01

373:D78K16E01R01 374:T36Q20E18G07R06D05A01 375:V42T21N15K12H02Q01I01 376:I76V21T01 378:R54L20Q09M06S03K01 379:E30A26D21-09S04N02I01G01V01 380:R92K07

381:R41Q16T15P06L04S03W03M02K01N01 383:R81L04V03T03Q03C01 384:L83F15 385:S80E10A03T02 387:R83K15 388:P45G 15S09K09L05N05T03A02I01 389:Q38N20T12M08I06K03H03S02D01L01 390:L96M03 392:Y77L11F09 393:L42T37M19 394:E98D01 395:A96S03 396:F97V01 398:L83N08S02Y01T01F01 400:T30I27M21V12L06 401:F95L02Y02 403:H96Y03 404:S77T12A08V01 405:S98T01 406:F92Y06L01 407:L52V38I04M03 411:I97L01 414:S56C42 415:T96S02 416:T88S06I04V01 417:R47K42A06V01

418:D86A08N03 419:T97I01 420:S41T25V19A05I04N03 422:N84K07S05 424:Y56F43 425:Y59F37H02 428:K91R06Q01 429:D45G24E17K08N03 430:T45R41C05L04H01 432:V87T06I05 434:I55V43 436:Q90M09 437:W87Y12 438:Q96H02 439:V64I33 443:E34P34Q25I01 444:K54E24T12D02A01Q01N01S01

445:L79I10V05Q04 447:K43G29D10E10V03Q01 448:D78N11E08 450:S66F12N06L05D04E03Q01

451:E32S20T14A09L09V05K04M01 453:R46N36L03S03Q02K02I02D01W01 455:E76D20Q01

459:T39N31S20D02G02 460:A56P13E11D04S03T03L03K01 461:D55N14E08A06S06G02T01H01K01 462:G89R04N02D02 463:T58-33S03 464:E47T23A16Q03S02K01G01D01 465:I45V29L24 466:N81D10S06 467:K85R13 468:T27A18V13L12S09M05E03P02I02D01N01 469:L50E32D11A01 470:S51G28V08T05A04 471:E88D11 473:V91M04I03 474:M42L32I20V02T01 475:L33I28V19T07A06M02S01 478:L54M44 480:K86I09R03 482:R65K33 484:I81L15V02 486:E96D02 487:V28T25S12D08A06P04I03N03G02E01L01 488:I67L15V09P02F02M02 489:A72G27 490:R81K17 491:W47N24L14S05M02A01F01 492:E92Q06 493:V75I19M04 494:F90Y09 495:L87I08V03 497:L91I07 498:A69T22S07 499:I61T33A01V01M01

500:L76I07M07V07 501:L81I13V04 502:Q93H06 503:Q62R20K12N01G01H01 504:L79V14I02M02 505:E62K13H08R07Q04N01 506:F86L09I03 507:S60H07K06E06Q04Y03R03N02L02T01

508:V49K11L09N05S04A04E04I03T03P01G01 509:P29C17S11L09R08M07T04K03V03I02A01Q01

510:P73D12A04L01Q01S01E01 511:G92R04K01 512:V32E27Q10A07K07T04H03M01D01L01

513:K56E14P14Q05M03R01T01 514:V63L31P02A01 516:M52L36I09 517:T94S03 518:P96T01

519:I33E21Q13T12L08V02D02N01 520:Y96F03 523:T83S08A04V03 524:M89L08 525:K97R02

526:H69P14Y09-04N01 527:K50A27P07-05T03R02G01 528:R63P10K08-05H04C03I01T01 529:C84Y08-05 530:E56-35K04Q01 531:H63Q10C06-05Y03R02L02A01S01 532:F43L26V18-06I05 533:Q67R12- 06K04T03S01G01 534:A45V32I09-07M04 535:K23R23Q13T10S09-07E04H03A02W01

536:L27M19P16Q13K07-07V04A01R01S01 537:R90-07Q01

(iii) N14 1:-58M41 2:-59A34G05 3:-59T39 4:-40S33M 19G03A01 5:L38-28M 17A09E01T01R01V01 6:S34- 27A07D06L05G04N04Q02T01M01P01 7:P26-19M 17L12A08S04I03T02V01G01 8:D57- 19E06N05L03K02P01W01 9:-79T13S03A02 10:-80E 16L01 11:-80F19 12:-80G 17 13:-80V16L01 14:-80K17R01 15:-80G 15S03 16:-95S03 17:D27S20-18A09V07G06E03L03K01Q01 18:P29S21- 18T09H05V04A04E01I01R01L01 19:L28-18I 17W13Q06R05A02P02S02F01 20:P23- 18Q16I 15E07L05D03S02A01G01M01R01 21:P22-18L17R16S05D05E05A03G02K01M01 22:S21E19- 18N09I08M05L04F02A02T02V02G01 23:P23-19W18S11L09N05A05D02G01I01T01 24:L40- 19S16R05P04A04Q03K01T01G01 25:S42G20-19P05L04A03D02F01 26:T26-18S17Q15A12I04V02 27:Q39V19- 16L09P06A04T01 28:Q60-14R14H04V01G01P01 29:T38P19-14S13A06N04K01 30:T33A23- 14V09L07M05E01I01S01 31185-12V01 32:L61V22-12I01A01 33:L44A27-12T05V05S03F01 34:L38S30- 10F09C07A01T01V01 35:L56F18-10V09M02A01 36:S39V23T13-10C04A04I02L01 37:V43F19L18- 10I02C02A01 38:L87-10 39:A38F21V12-10L06C02M02I01T01 40:A48C20-10S07L03T02F02I02V02

41:V47L32-09I03M03F02 42:H61E20-08F04W02L01Q01 43:L33V29A24-07M02I01R01 44:G42C22W12- 08R04A02F01V01L01S01 45:Q39L28R12-08K08 46:W74R08-07L03S02T01H01Q01 47:L60V21- 08I03S02A01G01 48:L46R36-05Q04C01H01K01 49:R59N24-05Q04E01L01G01W01 50:Q45L23R11- 06W04H02N02F01K01 51:R62-13W05P03G02S02K02T02I01Q01 52:R43L21-16S04Q04A02N01H01K01F01 53:-50R44Q02W01 54:-49Q33K06R04P01G01L01S01 55:-49P31L08R05K01Q01 56:G26K22R13A10W09T04- 03V02H01L01S01C01 57:S41R31P09K04-03L02A01C01F01G01

58:R33A27S14G08E03T03Q02C01N01L01W01 59:P63L34V01 63:F95L04 64:A63P30Q03S02 67:L58V39I01 68:I71V27 71:A95V02L01 72:A61M22L08P02S02V02 73:Q57A26S09E04T02 74:L55V25M 16102

76:Q35P17N16S12R09K03H01T01 77:A59M23T06L02Q01S01Y01V01 78:P80S11A06 80:L68I25F02V02 81:S40T26Y24A06L01 82:F94L03C01 83:A52S24T15C02M02G01I01 84:R72K24D01T01 85:L74M25

86:A90V06R01S01 87:R47K33Q13S02G01 88:K47R45T04A01 91:D59N31A02T02E01S01 92:V97I02 93:F76Y23 94:Q97K01T01 95:I90L07M01 96:R70K16Q06H05 99:S60C23N08R04T01W01 100:C40R27S20W06N02Q02 101:P43D23T12N05A04R04Q01K01S01 102:V72I27 105:L98V01 106:N98S01 108:E52D21-20G02Y01A01 109:R47D16S10A05E04Q04K02G02T02L01 110:A83S08V05T01 112:R63H25K10 113:Q70E21K02P01G01H01 116:V71I22L05 117:Q60K23R09H03E02 118:Q63H24K10 119:G70S26A03

120:A39T22S12L05V04P04I03E02G01K01N01 121:A36E26D21T04I04V03H01Q01 123:A97S02

124:G60D38S01 127:P34D26N24S06R05K01 129:A42V20T18P10L02S01Y01 132:R50Q45K02

133:V39F19M 16L10Y06N01A01E01S01T01 134:V70I29 135:S94A04 136:G73N19D04A01

138:R60K19D09L02N02Q02H01 139:S97G02 140:L58M34I03V03 141:A76T21 143:G63T19S10N05 144:- 98T01 145:N28H16T13Q12S07G06P05R04K03C01 146:Y85V10S02F01 147:S84T10G04

148:E51K19D15Q06P01G01T01 149:Q23W17R17H 12L10S09A02N02 151:K93R04Q01

152:A31V29M12L11T10I01 153:H53Q41R04 154:R98K01 155:R58K40 156:A39I23V23L10S01

158:Q44H42Y07F03 159:S81G08A04T03N01 160:T85S05M04I02A02 161:V35M32L16I 14

163:A71M 13N08T05S01 165:S95F01A01T01 166:T72S21-02M02 167:R38G29A27-01V01

168:N49Q34H05S04-01K01E01G01 169:P58S26L03A02I02-01M01V01 170:R41Q40H05A04K02-01G01D01 171:T54S35G06A01P01 172:R49K47S01Q01 173:R41K38Q11T01G01H01N01S01 174:-98C01 175:-98S01 176:-98C01 177:V32T22A19L15I05C01P01R01 178:L49F48I01 179:E97Q01A01

180:G37Q37H06N05R04K04E03 181:H88Q08N01R01 182:V68I 17L09A05 183:L58V27T06A02I02Q01 184:G37A26S20C09D03N01 186:A73V11F07I03G02S01 187:R60T12M09Q06K05G02 188:E83D07A06F01 190:V70L17I11 191:A35R17E17Q16G04H03K03 192:L58V24I05A03R02K01S01G01 193:L49F48M01 194:V53L41A02S01 195:R67K08E06Q04A04N02G01S01W01 196:G39K20L17R11Q04H01M01E01

197:S68T19C06G04 198:A58S12R10K09T02E02Q02 199:G42E20D17Q05N02A02H02R02K01T01S01 200:G76Q07E05D01H01V01R01M01 201:A45Q28R13K06G02S01T01 202:F48Y37H04C02V02G01P01 203:F50L41V04I03S01 204:D56N18Q18H03Y01E01 205:P98L01 206:R28A27T12M 10S05G05H04L02V01C01 207:P30H21R17Q13T13N01 208:L30E25Y17P10S04N02V02D01Q01H01 209:L40T30F10I 10V04A01C01 210:V51T28I 12L04K01 212:A79S19 213:V54A24T17N01S01 214:A98C01 216:V78I 18T02 217:M79I 19 218:S69C28T01 220:V59L36I02 224:C40K34R16M03N02H01Q01 227:S56G23N09A02D02T02Q01

228:H80Y17F01 229:D76E 10G07N02S02 231:A45E15L10P09V05G03K02I02Q02S01M01

234:R57L25Q10T03K01A01 235:E38Q16T16A09R06G04N02S02D01 236:L75V21I02 237:L69V27I03

238:S42G38K06H04Q04R01E01 239:R48H40K05L01Q01N01 240:N76V13L05M03I02 241:E49D47N02 242:E38Q27K25R06 244:G78T20 245:R49Q20E17K11N01 246:T94A04S01 247:V98A01 248:G98A01 249:A98S01 252:L79I 18M01 255:V90A05F01I01 256:M58L39I01 259:L97M02 260:Q89R04K04L01

261:R31Y29S20L11N02T02C01 264:N94S04R01 266:V75I 19M02L01 267:R81K17 268:T65S27A06

269:A33V21I 17T11L08M05S01 270:F76Y21L01 271:R51E13D13Q11K06G01A01

272:N35E32Q09A06D06S05T02K01 274:K46E32Q11R06M01 275:Q41K10N10D08E08T05A04R03S02H01 276:L84I09V04 278:R61E 13Q08K06L04H01W01Y01 279:E45N35D13S02R01 280:F96L02

281:S44F23Y17T04N03G02C01L01 282:N38D14G 11A11T05S05E04V02Q02K01I01 283:F97Y02 284:V68I30 285:L38K21R16Q08H06F02Y01S01E01 286:D71G05N05S04A02E02K02L02T01 288:F49V49

289:L46V24E06M04R03F02A02K02S02I01D01T01 290:R36E28Q26K04H01L01 292:R88C05Q03H01

293:E59K19R06S05G02D02Q01A01 294:S57T40 295:L47F21I 13Y08M06V01

296:R34D19Q12N09E08V05K04T01L01H01S01 297:P82S13Q01 298:G53E16S15D05C02K02Q01R01 299:A46V27T16L02I02D01H01S01 300:A40T28I 15V06G04M02P02 301:-50P48 304:M88I08L02V01

305:M49S26T23 307:A97C01 308:F73I21L02V01 309:I98M01 310:L35V16G09N09R08S06H05I02A01M01Q01 311:S36V21A20L10H03I03T01G01 312:A36I25L23Q06V05S01 313:E39D24G23Q06R02N02

314:K39H17Q15E13R04T04A02N01 315:G21K19E17A08I07Q07-05L05S03R01 316:A34E15K12- 10R10L05D04G02T01S01 317:-37A30D09T08E04S04N01G01 318:-37G23E12K12T03R02A02S02D01V01 319:- 36G25D15T08S07A01M01N01R01 320:-49S35P06N03G01 321:-56G26D07S03E02Q01 322:-56D31E06G01 323:-45G34S09A02D02V02K01 324:G56D17-08E04R02P02N01F01S01T01

325:A34S16P11V10L06N05H04T02F02E02 326:R41G20S11L04K04E03T03A03-02Q01 327183S06- 02P01V01Q01T01 328:D46T16S10E07G07P04Q02-02A01 329:K41L32V08E05M03D02A01R01T01

330:E56D36A02G02-01 331:Y47F15H 15N14D04-01 332:V87T06A04I01 333:P56E26T06V05S03

334:A53S16P15G 12V01 335:T94V02I01S01 336:V69I23L03M03 337:T69G 16S06A05N01 339:I72L25V02 340:F74I23L01 343:S71G28 344:Q89L07F01M01 345:D98E01 347:L70V15M07I03T03 348:S98A01

349:T97S01 350:A84F06V04T02I01 351:L84M 10K02F01 352:Q78L09H09T02 354:L47I43M04V04 355:L63I25V09F01 356:L62I28V07F01 357:L71F10I 10V04Y02 358:L59F39 359:V41T36I 13A04L01M01 360:R59K39 361:Y84H11F02 362:P97S02 363:E45D37K05N05H02S02Q01 364:V54I31M08L03K01

366:A52T15K07Q06V06S04R02E01L01 367:R60K36Q02 368:L51V41M05I01 369:Q88H10R01

370:A39E39Q11K04L02D01 371:E72L16Q06D02 372:L42I28V24M03 374:Q38K30R28L01N01 375:V92I05 376:V95I02A01 377:G85D13 378:R92P02Q02K01 379:D64S15N08E06H01G01Q01 381:L96V02

383:C48S39T08R02A01 384:I37M26L15A08V06T03F02 385:E54D27G08S05A03 387:Q71R20K08

388:P67S15A08Q03V01C01G01N01 389:N41H25Q12S09R05K03E01 390:L96M02 391:P76A20S01H01 392:Y94L04 393:V58L28I 10T02 394:M64D23L05E03Q01T01 396:F96V03 397:L52I46V01 398Ύ97Η01 400:T32A30V18S13I01M01 401:M93L04F02 403:F93Y05H01 404:S55T43I01 407:V87L08I02T01

409:V73L21I02F02 411:I98L01 414:A49S43C05 416:T87V06N02I01A01 417:A34T30S25K04V02D01 418:D59N32S06 419:T50V26A22 420:S52T26F13V04C01L01 421:I48V42L08 422:L39M27E16N08G03D02S01 423:G91S07 424:Y73L21F05 425:H55Y10T10P05L04A03F02R02S02Q01 429:D73N23G02 432:V65I34 434:V60I39 436:Q98M01 437:W97F02 439:V85I08L04S01 441:H98Q01 442:D97N01 443:P96G01

444:V32A21L20S09Q08T04 445:K78M08I04L02N02T02 447:P36S26K22D04Q03A02T01L01

448:N52D26H10Q06E03 450:E63H23D08G02Q01 451:D39V24T12N06I06A02L02E02K01 453:D79N18E02 455:A37S24E10T10Q07G03L02V01 458:L95I03M01 459:D97N01 460:E43K38Q07P06A01D01

461:D44N32E07S05Q04K01T01 463:-98T01 464:F34A22S13L08K04E03G02C02M01Q01T01 465:L51I45F01 466:N70D29 467:K91R06S01 468:D89E03N03A02T01 469:L85K04R02A01I01F01M01V01 470:T58A37I02V01 471:S68N20T02A01C01D01G01F01 472:S61N25R06G03K02 473:V97F01 474:M77L22 475:I94L03V01 477:S98G01 478:V42L23T13A10M05I01S01 480:K95R04 482:R98K01 486:E72D22N01S01T01

487:E67Q28D03 488:L71I24V04 489:S73A26 490:K96R01M01 491:M56V28L08I05T01 492:Q65E22L09H01 493:L69V16I08M04T01 495:L94I02M01V01 496:F95L02Y01 497:I38T36F09S04V04L03A02 498:S52A43T03 499:I65L19V12T01 500:L88I09F02 501:A53L28V14I01T01 502:H98Q01 503:Q93E06 504:C97A01

505:N54S20T07H06D03R03K02I01 506:F85I 13 507:E25T24K23R19S01A01I01L01

508:A62S16K06T04V03G01N01P01R01 509:N61D17C06S05-04H04 510:P81Q09-04A04

511:D28N26S15A11E09K05G01 512:E70R07K06Q05S02V02G01D01 513:P53D24S05T05E03A02L01I01 514:S31L26P23A05V04F03-02W01 515:K43T28S15N07E02V01 516:M53L41I01V01

517:D61N17S11E04G02K01 518:F49C24Y20S04G01 519:S51N19T17K02E01H01V01D01I01 520:Y97H01S01 523:T88A06S03 524:I49L47M01 525:K97R01 527:K55L24H11N03-01Q01 528:S39P17A13D09H06R05N04- 01T01 529:F69Y26L01-01 530:-98E01 531:K42T17S15R10V03G02A02H01-01 532:I67V23L05M01-01 533:N40S20A16H10T09-01 534:V74A15T07-01M01 535:T54K22S19-01A01 536:L89P03A02V01-01 537:R98- 01

(iv) N17

1:-98M01 2:-98A01 3:-97M01T01 4:-93M05G01 5:-90M05P01T01 6:-90N02K02E01T01 7:-66M24A04l01 8:- 60A18M10V07I01 17:-58L24M06F05P01S01 18:-47M27S16A02T01W01L01V01 19:- 46I 17V12A06L06M05Q01P01S01 20:-42L34F06V05M04A03Y01 21:-41P24G 16S07L04E01R01 22:- 33F23L13S11Q06I05M04 23:-31ll7P14S12L06Q05A03V01F01G01 24:G31-

23I 15V09L06S04T03A02M01Y01N01 25:P32S27-19A08I05F02L01 26:I30V27F12-07L07M04Q03T02S01 27:S85-05M03L02T02 28:A61V32-02T02I01 29:T64S26M02-02L01P01 30:E96-01

31:L42V21S15G07I05F04A01-01 32:L95F01-01 33:L62V24I11-01 34:A88V06T01S01-01

35:S43A22M11L08I05V03T03-01 36:A58T17V13I05-01F01S01 37:I32V32T29A03-01

38:F73V10L05I04M03A01-01 39:C95-01 40:L85I06V04T01-01 41:V82I05L03G02M01T01-01 42:F59Y24L12-01 43:W46L41M07-01 44:V51L26I14A02T02M01 45:V37I26L24M05T02F01 46:R56K21Q19

47:A37S25F07T06L05Y04G02H02R02Q01V01 48:W26L23F22S12M03T03R02K01-01

49:R51Q30H09K03S02N01W01 50:P38Q25T22S03R02K01N01V01 51:R35Q17E15H15K09W02P02

52:V61I33L02A01 54:K64E21Q05A02P02G01 57:K73R17Q05S01 58:S55R25Q06N05K02P02T01 59:P68L30I01 61:G92E07 63:W47R25K19T02S01M01 64:G67P23S05A03 65:W44L27Y21F05 67:L52I37V04F03M01 68:I54L44 70:N59H38S02 71:V73M13L07I03A01 72:L96I01M01 73:E48T45Q01S01D01 74:L84V14

75:G73R20H01S01 76:K70S14N05R04A01Q01 77:N55D19K10S07R03T01 78:P88T10 79:H84Y15 80:L93V05 81:A45S35V15T03 83:T64S29A06 84:R56A17K10Q08E05S01 85:L55M44 86:S96R02G01

87:Q62K22E06R06A01 88:R56K24Q12C01H01T01 89:Y95F04 91:D85H05P04S02N01 92:V97I02

93:L42M30F27 94:Q76E21 95:I77V22 96:R60Q27H07T01K01 97:I96L03 99:S38T26M22C12 100:R50T46K01 103:L55V42I01 106:S96G02N01 108:L73S12N07Y03 109:D65E30N03 110:T95V03 111:I71V25L02 112:R76K22 113:Q98K01 116:V74I21T01L01 117:K51R44Q04 119:G94A04 120:D57E40N01 121:D82E17

123:K47M24A20S07 124:G98S01 127:D96N01 128:L95F04 129:Y85H10P01F01 130:S93T05 131:F94S03T01 132:T42R29Q15K05S04H01N01 133:L41F34Y13H09N01 134:I75V24 135:T31S29N20A12G03

136:D68N23E05G01 138:Q65K29H01E01 140:L53M46 141:T48A38S12 143:S66N30G02 144:P62T31S02 145:D97E01N01 146:S69Q19K04Y01T01C01 147:G74A21V02 148:P45E28G23D01 149:V92I03A01

151:A46R32K19 152:A93T02L01 153:R97H01 155:K52R47 156:L97I01 158:Q75Y15M03L03H01

159:N67S25D06 160:A95G04 162:K57R26N16 163:S57T39N01 165:S92A07 166:I52T22V12S06L01N01M01 167:A63L21S08V01I01T01 168:S47P22E19A02D02K02Q02 169:D45S30G21N01 170:P72T13K05S05Q02 171:T45A34S06N05G02-02L01D01 172:S75P16A04L01 173:S59E22A06T03L02V01 174:S66Y24C05T01 175:S77T21I01 177:Y46L27V11A08M03 178:L97V01 180:E92D04M02 182:V77I21 183:S73C16T02R02I01 184:K92T02Q01N01R01 186:A80G14T02S01 187:E66D17L04N04K02S02Q01 188:Y61A20H09V05C01 190:I43V40L15 191:S30T21K20G11R04E03N03Q01 192:K58R19Q13E04T02 193:F52L45I01

194:Q48L26N09H03S03T02K01M01D01R01 195:E42Q25T10K08S06N03D01G01 196:L59V27Q08R01-01A01 197:M94T01-01S01 198:A40E22K17D08S04T02-01 199:E40G25A16K04T04V03R01S01

200:E20V20P15D12K11A07S05N03G01T01Q01 201:G74K21Q02 202:S38H27R21C03K03G01 204:D88E07N04 205:P92L06 206:Y58F26N07V03T01C01 207:R67N12S06Q06K02G01D01 208:Y57H22Q16E01

209:V46I28L20M02 210:V93L04M01T01 211:V83L05E03A02I01G01M01 214:A93T03V01 215:N95K02 217:I98V01 218:C74G22S02 219:A73G25 220:M80I18 224:K34R33Q29N01H01 225:R77H17N03 226:Y76F22 227:D58P21S12E03N02 228:H76Q16E02R02 229:D41N26S16H05E03K02R01 230:D61S21N09H07

231:Q69E19D05K03 233:L76M20F02 234:L89V09 235:S71N13G06D02R02 236:L61I27V08F01 237:V84I12L02 238:N68K13D03E03T03R01S01M01 239:L60N11S10V07M03E01T01 240:S65N18T09G02A02V01

241:N41D24H15E13K01S01T01 242:E70D18Q05N03K01 244:G60V30T02N01S01A01

245:E51Q18D16K05N02R02A01 246:V65T14I05S04A04N03G01 247:A55V30T12 248:A43G30S21T03 249:S87A07N01T01 250:G98A01 251:N89S04Y03H02 252:P93A02L02 253:A67V27S01T01 256:I72F26L01 258:I53V23L08F06A05 259:L96M02 260:R56Q38K05 261:Y87F08I01L01 262:L93M03F01 264:N55S42 265:P31R30S13T10K08A02Q01 269:T38A38S15G02N01K01 270:M52L46

271:K35Q25D17N07E03S03R02T02A01 272:R23K20L19A13T06I04V03N02F02S01G01 273:F97Y02 274:K69M10V09L05I03 275:D57A10N10S09E07R01Q01T01 276:F35I31L29V02

278:K24Q22R16A09D09E08N04T02 279:R70K24N01Y01 280:F92L05I01 281:N27L22Y18V09S08T03I03M01 282:S20R11Q10T10N07A06I06H05K04L04V04F02D02E01 283:F93L04 284:V39L35M 18I04T02

285:Q88R04K03E01H01 286:K91N02R02D01 287:I52M 18T15L08R01 288:V90I07L01

289:K40Q32S12T05R03N02E01 290:E96D01N01 293:K20Q20E14T13R11A11D03S02I01 294:T57D21S17K01 295:F79Y20 296:D64E26N08 297:K90E07 298:N32D26G25E10S03 299:N38H36S19R02 300:I86V13 302:R77Q22 304:I96V03 305:T94V03I01 306:D77G21S01 307:S75A23 309:I77F17L05

310:E43K25D23G03Q01N01A01 311:H85Q11Y01 312:C72S19N03Y02 313:Q43E42L07K03

314:D51E30K13N02 315:K44R28G 10N07S05D01Y01 316:K53S23R12P03Q03

317:L48V19R15A02D02T01M01Q01-01G01I01 318:D53A16G 11E10N02V01T01-01S01 319:E62S14A09- 04N03G02T01D01 320:N63-23D09S01 323:A44-23S21T07V01 324:N57G 18A09H05R03S03

325:I36V28G14T06D03L02R02M01N01P01 326:Q67L16P06H05A01 327:L39I32M 15V10P01 328:S65P32L01 329:D53Q16K11N10H04E02 330:E84K06Q03D02G02 331:K95N01S01 332:I87V07T05 333:V75I23

334:N58G25S10T02H02 335:I50L32V14T01 336:V92I07 337:N73L15M03F02I01S01Y01T01 339:L78I21 341:G98A01 345:D98E01 346:T96P02S01 347:V66I33 348:T70S25A04 350:A92G05T01 351:L53I44M01 352:S95T02Q01 354:S86A07C03G01 355:L72V22I03 356:M75L13V06I01G01 357:Y96L02 358:L87V07A02 359:V88A10 360:T58A22L10S03M02K01 361:Y47N28K07S07H05R02W01

363:E43D20R12N11S04K03G02H01 364:I70V25M02 365:Q96E03 366:K42R31E23 367:K71R27

368:I74L24V01 369:Q70H 15Y09F05 370:E61Q19K12R02D01A01 372:L88I09M02 373:D76K18E01R01 374:T41Q22E18R06D05A01S01 375:V49T24K11N08Q01I01 376:I73V24T01 377:G98D01

378:R62L15Q11M06K01S01 379:E35A27D24S03N02I02G01V01 381:R47Q19T18W03M03K02L01S01N01 383:R80L05V04T03Q03C02 384:L95F03 385:S90A03T02C01E01 387:R83K15

388:P48G 18S11L06N06T04A02I01 389:Q43N20T14M08H03K02S01L01R01 392:Y76L13F08 393:L48T28M22 394:E98D01 395:A96S03 396:F97V01 398:L96T01H01 400:T34I25M25L07V06 401:F95Y02L02 403:H96Y03 404:S87T09A02 406:F94Y03L01 407:L53V40M03I03 411:I98L01 414:S65C34 415:T96S03 416:T86S07I04V01 417:R52K47 418:D87A09N02 420:S46V22T20A06N03I01 422:N82K08S06C01 424:Y50F49 425:Y68F28H03 429:D48G27E20N02K01 430:R47T37C05L05H02 432:V94I05 433:F98L01 434:I50V49 435:N98S01

438:Q96H02 439:V59I38 443:P39E28Q28 444:K62E27T03Q01N01S01A01 445:L85V05Q05I02

447:K47G31E10D03V03Q01 448:D85E10N04 450:S72F14L05N02E01D01Q01 451:E37S22T16A11V04K03L01 453:R42N41L04S02K02I02D01W01Q01 455:E77D21 458:L98I01 459:T44N26S23D01A01

460:A64P13D04T04S03E03L03N01 461:D63E09A07N06S04G02T01H01K01 462:G93N03D02 463:T67-24S04 464:E43T26A19S03K01G01D01 465:I51V33L14 466:N79D12S07 467:K83R16

468:T30A21V15L14M06P03I02E01 469:L44E37D13A02 470:S58G32A05T02 471:E88D11 472:K98Q01 473:V90M04I03 474:M46L25I23V02T02 475:L38V22I 18T08A07M02S01 477:G98S01 478:L61M37 480:K96R03 482:R71K27 484:I93L03V02 487:V32T29S14A07P04I04N03L01 488:I75L17P03M02 489:A68G31 490:R78K20 491:W54N17L13S06M02A01F01 492:E91Q07 493:V83I15M01 494:F89Y10 495:L98M01 498:A78T12S08499:I70T27V01 500:L84M08I07 501:L79I15V04 502:Q96H03 503:Q61R21K13N02H01 504:L76V16I03M02 505:E71H10R05K05Q04N01 507:S69H09Y03Q03R02L02E02K01N01T01

508:V57L10S05A04E04I03T03K02N02P02G01 509:P33S12C10L10R09M08T04K04I02A01Q01

510:P71D14A04L02Q02E01N01S01 512:V36E31Q08K08T05H03M01L01 513:K61P16E10M03Q02R02T01 514:V72L21P02A01 516:M59L28I10 517:T97S01 519:I38E24Q15L10T07N01V01 523:T89S08 524:M88L09I01 526:H79Y11P07N01 527:K50A31P08T04G01 528:R72K09H05C03P02I01T01Q01S01 529:C97Y01 530:E64- 26K05Q02 531:H72C07Q07Y02L02-01A01S01 532:F49L23V21l02-02 533:Q73R14K04-02G01S01T01 534:A47V33ll0M04-03 535:R26K26Q15T12S07H04-03A02W01 536:L29M21Q14P14K08V04-03A01 537:R95- 03Q01

(v) N18

1:-94M05 2:-78M08A06R03V01W01 3:-78T08G07S02A01R01 4:-76M10L06V04P01T01 5:- 73M11I05K04R02L01T01V01 6:-73L12N06M05P01W01 7:-73S08M06V04A02T02F01l01 8:- 73G10D05A03V03F01N01P01Y01 9:-95T04 10:-95L04 11:-94F05 12:-94G05 13:-94V05 14:-94K05 15:-94G05 16:-94S05 17:-73L08Y04R03T03G02C01F01I01K01 18:-68L11S08M06V02I01Y01 19:-68S10L08F07P03N01 20:M56L14-13I05A03T03F01P01Y01 21:I42M15-11E11K11T02V02A01F01G01L01 22:F30L24E14S12- 11D05N01V01 23:D28N22S20-11G04H04A03E01F01I01R01V01 24:L32S14T13M11-08K07I04V03P02A01Q01 25:A47S21-08E08F04K04C01H01T01V01 26:V42I30A10T06-04K03M02G01 27:T54S21L06P05- 04A03I02N01V01 28:P45L27S06V06-04A04F02I01T01 29:G43S33E08-04K03M03C01R01Y01 30:E72S12D08- 04G02 31:V88-04M03A02L01 32:T80L06-04M04A03I01 33:T50V24I07-04A03F03P03L02M01 34:S60A17V08- 04M03T03C01I01 35:L88-04A03F02R01 36:I44C17L11F10V07-04T04 37:I42V25L12A07-04K03T03M01 38:L74F12-04A03I03M01V01 39:V60T14C06-04A04S03I02M02L01N01 40:I35M33L17V07-04A01

41:V52I24L12-04S03A01G01T01 42:F68L26-04 43:V51L17I 12M12-04F01T01 44:F53A22V07S06-04T03I01L01 45:V52l26L16-04 46:R78-04T04K03L03H02N01V01W01 47:A46V13G11S11-04E03L03T02C01I01K01M01 48:L66R17K05-04V03I01Q01 49:R34G27K12M12Q05-04W03 50:S61N24Q06-04R02K01

51:K48R21H08A06I03-02E02Q02M01N01T01V01 52:-77D10L10G01N01 53:G51R13H08- 07D04N04W03S02V02E01T01 54:R44K23T12G07-05Q02A01N01P01S01 55:K80D06R06-03A01G01V01 56:Q45R12F10H08V05-03E03A02I02Y02G01K01L01P01 57:V38P22L11K10N05M04G02I02-01R01T01 58:S76F04N04H02L02P02R02T02V02A01 59:P84L12A03 60:P98A01 61:G98S01 63:W63T11R08F05K05- 02L01M01N01 64:S65P28A05 65:F53W30L13V03 66:P97A01S01 67:I73L18V07 68:I70V27L02 69:G95E03Q01 71:L91F04M04 72:L87F07P03R01 74:L76M12V08I01P01 75:G97E02 76:D64E24K06A02N02 77:H66Q27Y05 78:P78I12M06L01V01 79:Y58H35F05 80193106 81:T62S36M01 82:F50L50 83:M51T40I07Q01

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94:L63Q18K12T03C01M01 95:I54L26M12V06 96:K72R24H03 97:L86F06M06 99:M62S26L04V04T02 100:V65L22R06M03E01I01 101:P76T11Q05V04L02 102:V95I03A01 103:V77L22 104:V94I05

105:V68L28A01M01 106:N72S27 108:M56Y22L10I04T02-01A01H01V01 109:E74D08N08S04A02T01 110:M58T33A06P01 111:V71I28 112:K84R15 113:Q75E06H06R05K03-02 114:V65A30G03I01

116:L61V28H06A01F01I01 117:K71R27Q01 118:D61Q28E04N04H01 119:G94A03R01T01 120:E97D01N01 121:H48D13N13A10S10K02L01Y01 122:F98Y01 123:A98P01 124:G93D03-02R01 125:R95-04 126:P96-02S01 127:N55D24E10K05H03A01 128:M62L24F13 129:H58F20Y17M02T01 130:T83S12C02F01I01 131:F96I02N01 132:S90Q06P02I01 133:F66A18L07V05Y01 134:L51V18F16I 12M01 135:A81S13G04P01

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227:D85E11G01N01S01 228:H86Y12-01 229:S51N32D06F03H03-01G01T01 230:D98N01 231:E61K35Q03 232:E97D01K01 234:L94I05 235:R38T25K20N08S04G01Q01 236:I83L10V05M01 237:V74I24F01

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279:A50R31Q07S03-02V02K01M01Y01 280:L72M21F03P01V01Y01 281:N94H03S01Y01

282:G27Q26N11S08E07R07D06H01K01L01 283:F98Y01 284:I74M21L02V02

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312:C92V05G01S01 313:H57E20Q12K03N03D01R01Y01 314:N45D30E12K07-02G02 315:K73R26

316:Y44K17E12H08N06Q05G01R01S01T01 317:A57E18S11V04K03-02I01T01

318:A36D18T16N08S06E05V03-02G01 319:T48K10D08G07A05R04H03S03-02I02E01Q01W01

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491:N70L22M06I01 493:I47M33V15L02T01 494:F97C01L01 495:I60V23L15T01 496:F92I06L01

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163:A61M 18N11T07S01 165:S95F02A01T01 166:T94-03P01 167:R53G39A04-02 168:Q47N31H08S05- 02K02E01G01 169:P79L04A03I03S03-02M02V02 170:R55Q22H07A06K02-02G02D01N01

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186:A66V15F10I04G03T01 187:R82K07Q06G03 188:E86A09D01F01Q01 190:V65L23I 10

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224:C55K27R12N03H01 227:S73N13A03D03T03Q01R01 228:H73Y24F01 229:D74E11G 10S03

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244:G70T28M01S01 245:R66K15Q15N02 246:T92A06S01 247:V97A02 248:G98A01 249:A98S02

252:L72I25M02 255:V88A07F02M01 256:L52M45I02 259:L96M03 260:Q92R06K01 261:R42Y39L15C02H01 264:N92S06R02 266:V67I26M04L02 267:R75K24 268:T84A08S06 269:A46I20T15V08L05S02M01

270:F89Y08L02 271:R65D18E07Q04G02A01 272:E44N20Q13A09D07T02K01S01 274:E43K31Q14R09M01 275:Q56K14E10D04T04A03R03N02S01 276:L92V06I01 277:N99L01 278:R81L06K04Q04H02Y01

279:N49E27D17S03R02 280:F97L02 281:S61Y21T05N04G04C02 282:N49D17G09S06E05V03Q03A02K02 284:V63I36 285:L52R21H08Q08F03Y02E01S01 286:D75G07K03S03A02E02L01N01T01Q01 288:F67V32 289:L59V20R05F04K02M02I02S01T01A01 290:R50E28Q13K05L01 292:R84C08Q04H01L01

293:E53K26R07S07G04N01 294:S67T30R01 295:L65I 17M09Y03F02V01

296:R47Q16E11V07D05K04L02H01S01N01 297:P75S19Q01D01L01 298:G70S20C03K01R01A01

299:A63T21V05L03D01H01S01I01 300:A54I21V08G05T04M03P02 301:P66-32 304:M93L03I02V01

305:M67T32 307:A98C01 308:F96L03C01 309:I98M01 310:L49V22R09H07I03A02S02M02Q01

311:S49A26L14I04H03T02 312:A50L28Q09V07I03S01 313:G31D29E25Q08R04

314:K48Q18E13T06R05H03A03 315:K27E24G 10I 10Q10-07L07S01D01 316:A46R14-13K08L07E06T02S01V01 317:A42-16D13T11E06S05N02K01 318:G30E17K16-16T04R03A03S03D01V01P01Q01 319:G34D20- 13T12S09A02M02N01R01E01 320:S48-31P09N04G01A01K01T01 321:-41G36D10S04E03Q01R01T01 322:D43-42E08G01H01T01Y01 323:-39G39S11D03V03N01 324:G73-11R04P03N02F01S01T01

325:A47P15V12L09S05H04F03-01R01 326:R51S16G 11L06-04A03Q02F01K01P01Y01 327:L79S09- 03P02V02Q01T01G01 328:D63E10G 10P06Q03S03-03 329:L45K28V09M05E04A02D02T02 330:E70D25- 02A02K01 331:Y54N19H14D06-02F02S01 332:V97I02 333:P76T08V08S04 334:A57P21S15G05

335:T94V03S01A01 336:V63I30L04M02 337:T72G22S03A02 339:I95V03L01 343:S97G03 344:Q97F02 347:L96I03 350:A97T02 351:L92K03M02Q01 352:Q86L13 354:L64I30V04 355:L66I28F02V02M01

356:L49I39V10F01 357:L60F14I 14V06Y03 358:F54L45 359:T50V32I 15M02 360:R80K19 361:Y95F04 362:P96S03 363:E54D34K07H01N01 364:V69I22M07 366:A61K08T08Q07V07E02L02M01 367:R80K16Q03 368:V56L34M07I02 369:Q97H02R01 370:A53E27Q08K05L04D02 371:E96D03 372:L55V34I07M03

374:Q51R28K19 375:V90I08 376:V94I04A01 377:G80D18 378:R96K01H01 379:D64S19E07N03H02Q01 381:L95V03 383:C63S23T08R03A02 384:M35I31L21A08F03V01 385:E41D35G 11S07A04 387:Q96R02K01 388:P86A06Q03S02 389:N42H28Q16K05R04E02S01 390:L98M01 391:P97H02 393:V77I 15L04T03

394:M87L07E03T01V01 396:F98V02 397:L70I27V01 398Ύ97Η02 400:A41V25S18T09I02F01M01

401:M94F03L02 403:F97H02 404:S71T28 407:V83L11I03T01 409:V70L23I03F02 411:I98L02 414:A65S26C07 416:T82V09N03I02A01 417:A46T42K05V03D02 418:D45N45S09 419:T69A30 420:S69F17T05V03C02L01 421:V51I37L10F01 422:L53M37N08 423:G94S05 425:H49Y13T13P07L06A04F04Q01 426:I99V01

429:D64N32G03 431:V99I01 432:V53I46 434:V76I24 436:Q98M01 439:V80I 12L05S01

444:V43A30S11T06Q05E01G01L01 445:K79I05M05L04N03T03 446:W99F01

447:P49S34D05A03Q02L01T01H01V01 448:N69H14Q08D04R01S01 450:E85D11G03

451:D54T16N09V07A03E03I03K02 453:D76N21E02 455:A47E15Q10T10S06G05L03V01N01 459:D96N02 460:K52E25Q10P09D01A01 461:D59N22E05Q05S03K02T01 463:-97T02

464:F47A14L12S08K05E04C03M02I01 465:I62L35F02 466:N90D10 467:K97S02 468:D85E04N04A03T02 469:L95K02M01 470:T50A45V02I01 471:S87T03A02D02G02N01 472:S61N25R09K03G02 473:V97F02 474:M72L28 475:I92L05V01P01 477:S97G02 478:V55L32M07A02T01Q01 480:K93R06 486:E97D03

487:E92D05Q02 488:L93I04V03 489:S97A03 490:K97R02 491:M76L08I07V06T02 492:Q80L13E03H02 493:L93M06 495:L98M01 496:F95L03Y01 497:I53T34V06L04F02 498:S71A24T04 499:I68L26V03T02 500:L85I13F01 501:A73V19L04T01 502:H97Q02 503:Q91E09 504:C98A01 505:N74H08D04R03K02S02T02I02 506:F81I 19 507:T33K32R26S02A02I01L01E01 508:A82T06V04S03P02G01 509:N69D14-06H05S04

510:P80Q13-06 511:N34D31A14E13K05 512:E70R10K08S03V03G02D01 513:P61D16S08T07E03L02 514:S43P28L12A07V03-03W01 515:K59T19N10E04S04V01P01 516:M68L26I02V01P01

517:D60S16N13E06G03K01 518:F68Y24S04G02C01 519:S38N26T21K03H02E02V02D01L01 523:T95S03A01 524:I67L28M02 527:K75H 15N04Q01L01R01 528:S53P19A18D03N03T01 529:F87Y11L01 530:-97E02 531:K51T15S14R07V05A03H02Y01 532:I69V22L07M01 533:N54A22H14S08 534:V97M01 535:T71S26A01 536:L91P03V02A01H01

(vii) N21

1:-98M01 2:-97A02 3:-96M01T01 4:-91M06G01 5:-87M07P02T01 6:-87K02N02E01T01S01W01 7:- 84A06M03I02W01 8:-76M llA06V01l01D01 11:-98F01 12:-98G01 13:-98V01 14:-98K01 15:-98G01 16:-98S01 17:-72M09F06L04P01S01G01 18:-62S21M09W01A01V01 19:-61V10A08L08M04Q02P02 20:- 55L14F09V06M05A04Y02 21:-54G21S10L06E01R01V01 22:-44S14L13F12Q08M05 23:- 42P19S16Q07A05L02G01M01R01 24:-30l20V12G09L08S05T03A03M02Y01N01 25:P31- 25S21I07A05F03L02N01 26:I33V19F16-10M06Q05T02L02S01 27:S81-06M04L02T02 28:A80V11-02T02I01 29:T84S05M03-02P01 30:E96-01 31:L57V25I07F06A01-01 32:L95-01 33:L82I 10V05-01 34:A84V09T02S01-01 35:S57A29T04L02-01V01I01 36:A72T11V08-02F01S01 37:I43V41T09A04-01 38:F96L01-01 39:C94-01A01F01 40:L91I05-01 41:V77I06L04G03M02T02-01 42:F78L17-01 43:W62L27M05-01 44:V68L24A02I02

45:V48I32L10T03F02A01 46:R64Q24K07 47:A50S31T08G03R02 48:W35L27S16F11R03T03-01

49:R56Q34K04S01W01 50:P51Q33T06S03V01 51:R46Q22H20W03K03P02 52:V82I 11L03A01 53:P97R01 54:K84Q06P02E02H01 55:G97K01 56:L95R01T01 57:K92R06 58:S74R14N07K01T01 59:P89L09I01 61:G90E09 63:W63R33M01F01 64:G90S04P02A01 65:W60Y28L07F03 67:L65I21V06F04M01 68:L59I39 70:H51N45S02 71:V70M 18I04L04A02 73:T60E33Q02S01M01 74:L97V01 75:G71R27S01 76:K93S03R02

77:N59D25S10T02Q01 78:P85T14 80:L92V07 81:A60V20S14T04 83:T52S38A08 84:R74K12Q11 85:L74M25 86:S96R02 87:Q81R07K05E02A02 88:R45K33Q16T01 92:V98I01 93:L55M40F03 94:Q69E28 95:I71V28 96:R80H08Q04T02K01S01 97:I95L03 99:S50T30C16M01 100:T62R33K02 101:P98Q01 103:L74V25

106:S98N01 109:D83E11N03 110:T98A01 111:I92V05L02 112:R72K26 113:Q97K01 116:V98I01

117:R59K35Q05 119:G93A05 120:D60E37N01 121:D96E02 123:K63M32A03 127:D96N02 128:L93F06 129:Y82H12P02F01 130:S92T07 131:F94S04 132:T56R20Q12S05H02K01N01 133:L54F15Y14H12N01 134:I66V33 135:T42S33A16G04I01 136:D66N28E02G01 138:Q87K07H02E02 140:M61L37 141:T62A22S14 143:S55N40G03 144:P83T10S02R01Y01 145:D96E01N01 146:S93T02C02Y01 148:P61E37D01

149:V93A02R01 151:A61K26R10 152:A96L01 153:R97H01 155:R63K36 156:L97I01 159:N84D08S05 160:A93G05 162:K76N21R01 163:T49S47N02 165:S97A02 166:I67V16T09L02M01S01 167:A85S10T01G01 168:S63P30A03E01 169:D60S38N01 170:P96K01L01 171:A46T39N04G03-03S02 172:S93A03

173:S79A09L03T02V02 174:S88C07T01 175:S69T28I01 177:Y62L35 178:L96V02 180:E90D06M02

181:H97N01 182:V95I03 183:S86T03R02I02K01N01 184:K90T03Q02N01R01 186:A98V01

187:E64D22N05S02K02Q01 188:Y54A26H08V07C01 190:V39I39L20 191:S40T28G 15R05N03K02I01Q01 192:K78R17T02 193:F69L30 194:Q62L35 195:E55Q33K08D01 196:L78Q11V06R01 197:M94-01S01I01T01 198:A54E24D07S06K03-01T01 199:E53G34K05R01 200:V26E21P21K13A09G02S02T01Q01 201:G65K29Q03 202:H36R27S26C04E01 204:D86E07N06 205:P89L08A01 206:Y76N09F04V04T01C01H01

207:R56N17S09Q08K03G02D02 208:Y67Q21H07E01 209:V61L27I06M03 210:V90L06M01T01

211:V77L06E04A03I02G01M01 212:S98A01 214:A91T04V02 215:N94K03S01 217:I98V01 218:C65G30S03 219:A96G02 220:M76I21 224:K45Q38R12N01H01 225:R69H23N05 226:Y69F30 227:D59P28E04S03N02 228:H69Q22E03R03 229:D38N26S22E04K03R01T01 230:D51S29N10H09 231:Q64E25K04D03

233:L68M26F03 234:L96V02 235:S76N14D03R02P01 236:L52I34V11M01 237:V79I 16L03

238:N60K18D04E04R02S02M01T01G01H01 239:L51N15S14V09E01M01T01 240:S56N24T12G03V01 241:N55H19E12D06K02S01T01 242:E66D18Q06N04K02 244:G56V34T03A01 245:E68D22N03K02A01 246:V57T19S05A05N04I04G01M01 247:A69V16T12 248:A54S25G 14T04 249:S86A09 250:G98A01

251:N86S05Y05H02 252:P92A03L03 253:A56V36S01T01L01 256:I63F35L01 258:I56V29L09F02W01 260:R58Q34K06 262:L91M04F02 264:N62S35 265:P41R33S17T05 266:-98V01 269:A48T26S17G02N01P01 270:L61M37 271:Q34D23K18N09E04S04T02R01A01 272:R26L25A15K07I06T04V04F03G02S01 273:F96Y03 274:K92I03M02L01 275:D61A12S08E08N05Q01T01 276:F47L35I 12V03 278:K31Q30R18E11D03T02 279:R61K32N02Y01T01 280:F90L07I02 281:L30Y24N 13V12S08I02M01H01

282:S24R14Q13H07I07A06L06V04F03D03N02K02 283:F92L05S01 284:L47M22V22I05T02

285:Q87R06E02K01H01 286:K91D02N02R01 287:I40M24T20L08R01A01K01 288:V86I 10L02

289:K52Q43E01R01 290:E95N01K01 291:H98C01 293:K27Q26E14R12T12S03 294:T49D29S17K01

295:F88Y11 296:D59E35N04 297:K87E10P01 298:N39G33E 13D07S05R01 299:H49S25N18R03V01

300:I81V18 302:R69Q30 304:I94V05 305:T92V04I01 306:D69G28S02 307:S67A31 308:L98F01 309:I69F23L07 310:E57K33G03Q02A01 311:H80Q15Y01 312:C62S25N04Y02V01 313:Q55E26L09K04M01

314:E40D35K18N03 315:K57G 14N09S07R06D01Y01 316:K38S31R16P05Q05 317:L33V24R21A03D03T02Q02- 01G01M01I01K01 318:D37A22G 14E14N02V02T01-01S01 319:E49S19A12-06N04G03T02D01V01 320:N51- 31D12S01 321:-98G01 322:-98E01 323:A50-32T09S03V01 324:N42G24A12H06R05S04D01

325:I35V20G19T08D05R02M01N01P01A01 326:Q57L22P08H06A01 327:L52I41M02V02P01 328:S53P44L01 329:D37Q21K14N13H06E03 330:E79K08Q04D03G02 331:K93N01S01H01Q01 332:I89T06V04 333:V67I31 334:N78S13T03H02G01 335:L44I34V19T01 336:V90I09 337:N63L20M05F03I02S02Y01T01 339:L70I29 341:G97A02 345:D97E02 346:T94P03S01 347:V82I17 348:T92A06S01 350:A93G04T01S01 351:I59L39 352:S94T03Q01 354:S93C03G01V01 355:L94I04 356:M77L18I02 357:Y96L03 358:L85V10A03

359:V84A13M01 360:T76L13A03M03K02S01 361:N37Y33K10S09H03R03W01

363:E29D22R17N15S06K04G02H02 364:I65V30M02 366:K53R42E02 367:K91R07 368:I97V02 369:Q91H08 370:E76K16A02D02Q01 372197102 374:T55Q30R08A02E01 375:V65T30I01 376:I92V05T02

378:R81Q14S01W01 379:E43A37D08S04G02V02 381:R63Q26W04K02L01 383:R93Q04 384:L96F02 385:S93A02T01E01 387:R98K01 388:P51G24S11L08A02 389:Q58T19M 10H04N01L01 392:Y97L01

393:T36L33M29 395:A98S01 396:F97V01 398:L96H01 400:T44M32I 12V07L03 401:F96Y03 403:H95Y04 404:S83T13A03 406:F97L01 407:V53L38I04M03 411:I97L01V01 414:S87C11 416:T95I03V01 417:R68K30 418:D84A12N01 420:S31V29T27A05N04I01 422:N76K11S08C01 424:F63Y36 425:Y87F08H03

429:G36D33E27K02N01 430:R63T16C07L07H03I01 431:C96V01 432:V93I06 433:F98L01 434:V61I38 435:N98S01 438:Q95H03S01 439:V68I29 443:Q38E38P20R01 444:K80E09T03Q02N02S01 445:L85V07Q05I02 447:G41K35E10D05V04P01 448:D88N06E04 450:S66F16L07N02E02D01Q01 451:E50T21A13V06K04S02 453:R56N29L04D02K01W01Q01 458:L98I01 459:T57N25S10A01D01 460:A58P18S05T05L04D03E02N01 461:D52E11A10N08S06G03T02H02K01 462:G91N04D03 463:T62-32S02 464:T33E30A25S03K02G01M01 465:I65V25L09 466:N73D16S09 467:K80R18 468:T39A27V16P04I03E02F01N01 469:L59E21D12A02 470:S77G 15A03T02M01 471:E84D14 472:K97Q01 473:V90I04M04 474:M39I30L24T02V02

475:L49I19V11T07A06M02S02 477:G98S01 478:L67M31 480:K98R01 482:R62K36 484:I93L04V01

487:T39V22S15P06I05N04A02L01E01 488:I67L23P04M03 489:A70G29 490:R72K27 491:W73L18M03S02F01 492:E89Q10 493:V78I20M01 498:A72T15S11 499:I62T36 500:L89M09I01 502:Q95H04 503:Q80R16H01 504:L68V22I04M03C01 505:E94H01Q01K01 507:S87R03N02K01T01F01H01 508:V76L14I05K01S01

509:P44S15C14R12T06L02Q01A01 510:P62D18A06L02Q02E01N01S01 511:G97K01

512:V48E21K10T06Q04M02L01G01 513:K79E12R02Q02P01T01 514:V93L03A02 516:M51L32I 14

517:T96S01D01 518:P98S01 519:I51Q19L13T09V01N01H01 520:Y98F01 523:T86S11 524:M84L12I01V01 526:H73Y15P09 527:A42K35P11T06G01 528:R64K12H07C04P03I02T01Q01S01N01 529:C97F01Y01 530:E86K06Q02-01D01 531:H83C09Y01A01S01 532:F66V26L03I03 533:Q96S01T01 534:V40A37I 14M06-01 535:K34R34Q20H06W02-01T01 536:L30Q18P15M 13K11V05-01T01 537:R98-01

(viii) N25

1:-92M07 2:-92A07 3:-90T08A01 4:-61M36L01 5:M35-33A29N01 6:-33A22L19Q09N08S02T01W01 7:M33L30-25T04I02S01W01 8:D60-25E11N01T01 9:T45-28S12A11E01G01 10:E61-28L05D02S01 11:F73- 25Y01 12:G66-28E02C01D01 13:V63-28L07M01 14:K66-25R04E02N01 15:G60-25S12I01 16:-84S14G01 17:S57-25G08L07N01 18:S74-25 19:I60-25L09S04 20:I54-25L08M07Q02T01 21:R59-25K05M05E02A01 22:E64-25S07A01G01 23:W63-28S08 24:S60-28T07R02G01 25:G63-28S08 26:Q59-28I07H02S02 27:V61- 25L09I02 28:Q49-25H18V07 29:P63-25S08A01T01 30:A67-25E07 31:L70-22V07 32:V60-22L09I07 33:A67- 22V09 34:S76-16T04A01F01 35:F54L22-16A04V01 36:V71-16I08L02 37:F67-16V08I07 38:L83-16 39:F66- 16C08V07S01 40:C67-16F07I07A01 41:L71-16I07V04 42:E73-16F07H01Q01 43:A74-16L08 44:C74-16V07R01 45:L81-16F01 46:W76-16T05R01 47:V70-16S07L02A01F01 48:R84L07K04-02Q01 49:N87R05W04-02 50:L83Q09F04K02 51:R73-08T08K07N02 52:L80-08F04H04I01Q01 53:-92R07 54:-92K05R01 55:-92K05R01 56:K84R14-01 57:R81K16-01 58:R94N05 59:L90P09 64:A88P11 67:V85L14 68:V91I08 71:A92L07 72:M80L19 76:Q90K07H02 77:M88Q07L02T01 80:I88L09T01 81:T90S08I01 82:F91L08 83:S57A30T11

84:K83R09T04A01E01 85:L90M09 86:A91R07S01 88:K98R01 91:N74D19E04S01 93:Y88F11 94:Q95T04 96:R91H04K04 99:C81S11W04R02 100:S78R11N09 101:D81N11Q07 102:I54V45 105:L95V04

108:D74G08E05Y05A04-01 109:R40A15Q12K11E08T08S01V01 110:A76V18S05 112:R88K07H04

113:E50Q40K08 116:I56V36L07 117:Q80K09E08R01 118:H88Q09R01 119:S84G 11A04 120:T74I 12E07A04S01 121:E90D08A01 127:N87D12 128:F98L01 129:V76L11Y07I02S02 132:Q98R01

133:M60F18N05A04S04T04L01V01 134:I53V46 136:G91N07D01 138:R54K40N02T01 139:S97G02

140:M50L47S01 141:T81A14S02V01 143:T74S12N07G02I01M01 144:-94T05 145:N81S16T01 147:S87G 12 148:K74E14Q08N01T01 149:Q87R12 151:K87R12 152:M42A32L08I05T05V05 154:R98K01 155:K94R05 156:I64L22V12 159:S83T09N07 160:T74S16A07K01 161:L52I47 163:A91T07D01 165:S98T01 166:S83T09M07 167:A88G09F01 168:N91E04K02T01 169:S97K01T01 170:Q90K07H01R01 172:K88S05R04-01 173:K87T05- 01E01I01Q01S01 174:-92C07 175:-92S07 176:-92C07 177:A60T21L05P04V04N02S01 178:F92I05L01 180:Q81H09E07K01 181:H64Q30R04 182:I57V42 183:V47T22L08A07I07Q05C01

184:A60G 19D12M02Q02V01 186:A92S05C01 187:T49M35Q11L02N01 188:E73D21F04K01 190:V92I07 191:Q47E35K12R04 192:V53I 19A12K07S05T01 193:F88L11 195:R47K29Q14E07S01

196:L56Q15R14H07M05Y01 197:S87G 11N01 198:A60S26T11G01 199:D38Q18N09H08E07K07R07T04 200:G95R02N01 201:Q60R39 202:Y67H15C07P04A02D01F01 203:F95S04 204:N59D25H12Y02 205:P95L04 206:A73S12T07V04E01G01 207:H81R09Q05N01Y01 208:E91Q07K01 209:L43F40I07A04V04 210:T92K07 211:V97E01I01 212:A98T01 213:A87V08S04 214:A95C04 216:V64I35 217:I63M35V01 220194105

224:K59R28M 12 227:G88D07S02A01 228:H97-01L01 229:D80E09N08-01

231:L36V18A08I08K07P07Q07M04F01H01 234:R77T12L07K01Q01 235:T60A19N11D05C01E01

236:L92V04I01M01 237:L92I07 238:G23K23H18Q18R05E04N02S01T01 239:R63K19L07Q05S02H01 240:V49L19M12N09I08 241:D87N08E04 242:K63R18E07Q07M02L01 244:G97M02 245:E64Q25N05K02R01 247:V92A07 255:V92F07 256:M92I07 259:L94M05 260:Q80K12R07 261:S73Y09N08T04F01L01R01 264:N92R05S01 267:R98-01 268:S84T11-01N01R01 269:V52M 15L14I08S07G01T01 270:Y56F36L07 271:Q35E30K23R09 272:N77S12T09 274:K90M05E04

275:N33D15T09Q08H07S07A05R04E02K01L01V01W01 276:L63I33P01S01 277:N95L02Q01

278:E49Q28K14R07T01 279:E85R07D05A01 280:F91L07V01 281:F88N07Y02L01

282:A35T19G 18D09N08I04S01V01W01 283:F88Y09L01 284:V74l22-02 285:K74Q18-02R01S01T01 286:D60N15K07S07L04-02G01H01 288:V98L01 289:V38E23L12K08M08D05I01Q01 290:Q59E35K04G01 292:R97L02 293:E76R09D07A04Q02 294:T67S32 295:F74Y25 296:D63N30T05

298:E56D21G09K05Q04H01N01 299:V97I01N01 300:T88I09V01 301:-94P05 304:M71I23V04 305:S91T08 307:A94C04S01 308:I80F14V04M01 310:N38G32S15A07R05E01 311:V80H09A04G04L01 312:I81L11V07 313:E71D09N09Q07S01 314:H53E21K16N04Q02R01 315:G49A25S09K07R05E01N01 316:E35K32D18- 05G04A01Q01S01 317:-94K02T02 318:-94D04G01 319:-95D04 320:-95N04 321:-91G08 322:-91E08 323:- 60G 18S15K04T01 324:D67E15G07N07-02 325:S49N16T11P07E04V04H02C01G01Y01

326:G35E12K12R12T12A11M01S01 327:L98I01 328:T60S33A04D01 329:K76D08E08V04N01R01

330:D59E26G08A04S01 331:F53H25Y19N01 332:V54T23A14I07 333:E91V07P01 334:A43G30S21V04 336:V90I05M04 337:T66S18A15 339:L94I05 340:I90F09 344:Q57L28F07M07 345:D95E04

347:V56M28I 14T01 349:T95S04 350:A42F22V15T08I07C01L01S01 351:L60M35F04 352:Q64H35

354:I74M 15V07L01S01 355:L53V29I 16 356:L97H01I01 357:L92Y07 359:V69A18I05M05L01 360:K98R01 361Ύ60Η39 363:D45E28N 14S08H01I01Q01 364:I61V14M09L07K05Y01 366:T33A29S15K05R05E04V04H01 367:K95R02T01 368:L91V05I02 369:Q59H40 370:E76Q22K01 371:L64Q25E09 372:I92L04M02

374:K60R33N04Q01 375:V98A01 376:V92I07 378:R84Q09P05 379:D70N16E04S04G02Q01 380:R97-02 383:S81C08R07T02 384:I56V19T14F07M01S01 385:E97D01G01 387:R76K23

388:S50A18P14C04N04Q04G02V01 389:N45S32H14R08 390:L92M07 391:A77P16S05 392:Y84L15 393:L90T07V02 394:D90E09 396:F85V14 397:I98V01 398Ύ92Η07 400:T92I07 401:M92F07 403:F76Y16H07 404:T84S09I05 406:F98Y01 409:V74L16F08 411:I95L04 414:S97A01L01 417:S91K07T01 418:D98G01 419:V91T08 420:T84V09S05 421:I74V18L04F02 422:E63N15G 12D04S04 423:G84S14D01 424:L80F09Y08V01 425:H70S09R08F07T04 426:I98T01 428:K98R01 429:D94G05 432:V98I01 434:I83V16 436:Q95M04 437:W91F08 438:S98P01 441:H95Q04 442:D94N05 443:P97H01S01 444:L74Q18S07

445:K69M16L07I02Q02R01 446:W97F02 447:K76P08Q07S04R02T01 448:D88E11 449:P97A01H01 450:H83D08Q07E01 451:V63I 15L08K05A04T02 453:D78N16E04 455:S70T12A08E07M01 458:L83I 12M04 459:D95N04 460:E98A01 461:N70S12E11T02H01Q01 462:G97-01X01 463:-92T07

464:A46S29G11E07D02V02 465:L98F01 466:D74N25 467:K80R14S05 468:D91T07E01

469:L59K15R11I05F04V02A01 470:T84A11I04 471:N73S15D07C04 472:S61N28K07G02 473:V94F05 474:M94L05 475:I94L02P02 477:S92G07 478:T49A38V05S04I02 482:R95K04 484:I98P01

486:D66E14N07S07T05 487:Q91E08 488:I81L09V08 489:A97S02 490:K91R07M01 491:V88M09A01 492:E84Q15 493:V61I25M07T04L01 494:F98Y01 495:L83I09V04M02 496:F97I01Y01 497:T35F30S15A09L08 499:I52V39T07M01 501:L95I04 502:H92Q07 504:C97L02 505:S69T15K11R04 507:E94K05

508:S59K25N05R05A04 509:N32D29C23S14 510:P83A15S01 511:S59D21K09G05N04

512:E70Q21K02D01L01N01V01 513:D46P33E09A07N01T01 514:L71F14V08P04I01 515:T50S45V04 516:L92M07 517:D64N32E01G01 518:C80S11Y08 519:S88T11 521:G95-02S01 522:L97-02 523:T77A16- 02S01V01 524:L90M07-02 525:K94-02R02 526:P97-02 527:L81K08-05W02F01 528:D26H22R19N12P08- 05Q02Y01 529:Y60F26-05L04C01H01 530:-92E07 531:T21R19S19K18H07-05G05C01N01 532:l63V23L07-05 533:S53T36-05R02A01 534:A56T28V09-05 535:K83T09-05R01 536:L83Pll-05 537:R94-05

(ix) N27

1:-85M 13Q01 2:-88All 3:-86TllA01 4:-60M37D01 5:-45M44E08T01 6:-45D29N13A06V03E01 7:M44- 19L11I08V04F03S03T03R01 8:D52-19L14P04Q03G01R01S01 9:-93T06 10:-93L06 11:-90F09 12:-90G09 13:- 90V09 14:-90K09 15:-90G09 16:-90S09 17:V32-16G 13L13A09E04Q04I01K01Y01 18:T26V19- 16S16A09I06H01K01P01 19:L50-16A11F04I04S04M03R01V01 20:E26-16D16L08P08G06Q06R04A03T01V01 21:S22D18E18-16G 11M06A04I01 22:M21-16L16F13S13V08A04I04E01 23:N24S21- 16L13D09G04I04P01T01V01 24:P19-16A16R14Q11T08G03C01H01K01L01S01W01 25:L19- 16G 16P14A13S11F06V01 26:S32T22A18-13I08E01M01N01 27:L31P31A16-13T04D01K01 28:R63- 13V08G06Q04E01K01 29:S39A26N21-13 30:V39L29-13E08A04I04 31:L85V08-06 32:L65V22-06A04 33:A39T26V14S11-06L01 34:S47C34Lll-06 35:L39V34M 13-06A06 36:T54V21A16-06S01 37:L65V14C11- 06F01 38:L91-06V01 39:L29V22F19M09C08-06A01T01 40:A39S32L11I08-06V01 41:L36V22M 13F11I08- 06A01 42:H60F18-06W06L03R03Q01 43:L88R04-03F01W01 44:W45R14-09F08V08C04A01I01L01M01S01 45:R50L34-09K03T01 46:W60R13SllT06Q04-03 47:L54S11-09V09I06G04F01R01 48:R50- 13Q11C08L08W03G01P01V01 49:R68-13G04Q04W04E01P01 50:R45Q19-16N08W04C03L01 51:R42- 19P14S09G08W03K01 52:-49S18AllL09N06D01H01K01 53:-88Rll 54:-88K06R03P01 55:-88K06R03G01 56:A32T18R13V09-08H08P03G01I01L01S01 57:P39R19S11-08K06G03H03L03C01D01T01

58:G34R24S09C08N06L04Q04W04T01 59:P49L42V06I01 63:F80L18R01 64:A62P27S09 67:V75L19I03F01 68:I96V03 71:A91L08 72:A68P13L09V03M01S01T01 73:Q93E06 74:L90M04V03I01

76:N65K13S09T04D01H01Q01R01 77:A55T24Q08S06L03Y01 80:L83F11I04 81:Y86S13 82:F78L13C08 83:T52S31M 11A04 84:R90K09 85:M95L04 86:A60V29R08S01 87:K34Q32R29H01S01 88:K95R03H01 89:Y98F01 91:D45N39T09E01H01P01 92:V98I01 94:Q93T04R01 95:I93M04V01 96:K62Q31H04W01 99:S86C08N03A01 101:T45A19N 11Q08D06P03K01R01S01 103:V98L01 107:G98C01 108:-88Y06E03D01 109:D75E14G09 110:A65S32T01 112:R52K47 113:Q67E19P08G01S01T01 116:V73I26 117:K93Q03H01R01 118:Q63K32N01R01 119:G88A11 120:L26P18V14A09S09E08T06F03K01Y01 121:D86E06H04N01 123:A91S08 127:D98N01 128:F98L01 129:T68A21Y08S01 132:R45Q44K09 133:F65Y31H01I01 134:I62V37

135:S77A19F01G01 136:N75D11G06A01C01H01S01 138:D42K31Q09N06R06E01H01 139:S91G08

140:M54L39I06 143:G72S14N13 144:-93T06 145:T52N39D01K01P01R01S01 146:V45Y36F08S08A01 147:S50T37G 11 148:D62E21Q06G04P04 149:W80R11S06G01 152:V37T31L22A03M03S01

153:H95L01Q01R01 155:K57R42 156:V67I 18L11A03 157:A98T01 158:Q75H24 159:S88N08A01T01

160:T90A08S01 161:V86L09I01T01 163:M60T21N09A06K01 165:S98T01 166:T96A01V01 167:G86A11S01 168:N90E04K03D01 169:P63I 11S09M06A04L01V01 170:Q62H21K08D03N03R01 171:T98S01 172:K90S06- 01R01 173:K59Q13R11T08N03-01E01H01 174:-91C08 175:-91S08 176:-91C08 177:T73A11L04P04V04 178:F88I08L03 179:E98K01 180:Q36N24H16K11E08R01S01 181:H95R04 182:V81I 16L01

183:L54V32Q06C01I01R01T01 184:S44C31A13M03Q03G01N01V01 186:V34F32I 13A09G09 187:R52K24G 11Q11 188:E93F04Q01 189:L98M01 190:L70I21V08 191:R40G 19H14Q13K08A01S01

192:L78R08A04V04I01Y01 193:F91L08 194:L62V32M03T01 195:R34A19E19N11G06H03K01L01V01 196:K83L09E04M01 197:T81S18 198:R47K34S08Q04A01E01N01 199:E75A09K08G01Q01R01T01

200:Q34E19G11D08H08V08M04L03R01 201:Q63K16R13G06 202:Y63F24P04A03H01Q01

204:Q80D11E04H01R01 206:M45H18G 11L11T08A03C01 207:T60R32A03N01Y01

208:Y75D08Q08N03E01F01L01 209:L86I08V04 210:V83T16 212:S86A13 213:T75V22M01 214:A95C04 216:V47I40T11 217:M86I 11T01 218:S85C09T04 220:V81I11L06 224:K80N11R08 227:S70A11T09D08 228:Y77H14F04-01N01 229:D59E36-01G01N01 231:E55A36K08 234:R42Q37L14A04 235:Q72E11A08N08 236:V88L11 237:V88I08L03 238:G91K04N03 239:R91L08 241:D93E04Y01 242:Q75K16E08

244:T85G08M03S03 245:K44Q44N06E01M01R01 247:V91A08 252:I81L11M06 255:V91F08 256:M91I08 259:L88M11 260:Q90R09 261:Y98D01 264:N91R06S01 266:I83V14M01 267:K80R18-01 268:T86S09-01N01 269:I63L18S08M04V04 270:F91L08 271:D59E22Q11G04L01 272:N59Q18D14T08 274:K95M04

275:K40E22Q13N08A04R04D01S01T01 277:N96L03 278:R52L18K13Q11A01E01V01 279:E77D14R08 280:F91L08 281:S40Y16N 14G 13T06C04F01V01 282:D44E18V11Q09A08K04M01N01 284:I98V01

285:R34Q26H21E04L04A01G01S01V01Y01 286:D65S09K08L04N03T03A01E01Q01

289:V60K08M08I04S04T04A03E01F01L01 290:E93Q04A01 292:R96L03 293:K86R09S03 294:T83S14M01 295:I50M29Y09L04F01K01V01 296:E36Q29D18L06S04K03R01 297:S57P36L03D01M01

298:S67G 14C11K04R01 299:T54V13A09L09H04I03S03F01 300:I63V21M 11T03 301:-93P06 302:R98G01 304:M90I04V04 307:A93C04S01 308:F93L06 310:V72A08M06S04L03I01K01Q01 311:A83H09S03I01T01 312:L86V08I03M01 313:D88Q08E03 314:Q55K16H11E08R08 315:I32G27L22K08S04N01P01

316:R45L21K16T08S03G01M01Q01 317:D40T16E14S11N08-03K03A01 318:K45G24TllS09D04-03 319:T37S24G 11M08-04A04D04P01R01 320:-63S14P09N08T03 321:-88G 11 322:-90E09 323:-90S09 324:G85N08-03E01R01 325:V37L26A18P08-03H03N01R01 326:S44L19-13A08F03P03Y03H01Q01T01 327:L40S29-09P06V06G03E01M01 328:G31D22E21S11-09R01W01 329:K85D08E01N01Q01T01

330:D65E32K01 331:Y85H08F04I01 332:V91I08 333:P31T27V26S11E01I01 334:P68S29G01

336:I47V34L11M06 337:G72T13S08A06 339:I85V09L04 343:S90G09 344:Q91F08 347:L88I09T01 349:T98S01 350:A91T06F01 351:L75K11M08Q03V01 354:I91V08 355:I78L09V06M03F01 357:I42L26V21Y08M01 358:L96F01I01 359:V90M06I01T01 360:K62R37 361:Y85F13H01 362:P96Q01S01

363:E72D18H04A01G01N01 364:I67M24V06L01 366:K27Q24V18T11L06E04A01M01N01R01

367:R86K11Q01 368:L90I04V04 369:Q91H06R01 370:E44Q26K16L13 371:E86D11G01 372:V88I 11

373:D96A01G01 374:K49R47L01N01 375:V96A01K01 376:V86I08A04 377:D60G36A01Y01

378:R93H03G01S01 379:S62E18D11N04Q01T01 380:R96H01Q01 381:L86V11F01 383:S62T16A08R08C03I01 384:I88F09M01 385:E83A11D01Q01S01 386:D98P01 387:Q90R08K01 388:P57A21Q11S06K01L01

389:Q52H24E08N08R03D01S01 390:L98V01 392:Y98W01 393:V65I 18L08T08 394:M88E09T01 395:A98S01 396:F93V06 397:I86L11V01 398Ύ91Η08 400:V83I08M03A01S01T01 401:M90F09 403:F91H08 404:T86S13 406:F98L01 407:V85I09T04 409:L68V22F08 411:I95L04 414:S80C18A01 416:T62V29I06L01

417:T83K13A01V01 418:D98N01 420:S80V09T08A01 421:I83L11F03V01 422:M70N26D01Q01 423:G81S18 425:T42P24A14F08H06R01S01 426:I96V03 427:P98L01 429:N54D34G 11 431:V96I03 432:I80V19 434:I68V31 435:N98S01 436:Q95M04 437:W98R01 439:I39V36L18S04T01 442:D95A01N01S01 444:A39S37T16Q04K01 445:K31I16M16L13N09T09R01V01 446:W96F03 447:S47D18P13A09T04V03G01H01

448:H44Q26D13N11R03E01 450:E57D36G06 451:T52V22I09A06K06S01 453:D73N26 455:E49Q34L08S04N03 459:D93N04S01 460:E34Q31P29A03K01 461:N32D19E16Q16S11T03 462:G98S01 463:-91T08

464:A45K18E14S11M08T01 466:N96D03 467:K93S06 468:D91T08 469:L90K06M01Q01 470:T85A06I04V03 471:S68T11A08D08G03 472:N57S32K08R01 473:V91F06M01 474:L88M11 475:I78L14P03V03

476:F96L01Y01 477:S91G08478:L75V08A06M06Q03 480:K88R11 484:I98V01 487:E75D16Q08488:L90V09 489:S91A08 490:K91R08 491:M60L26I13 492:Q83E09H06 493:L90M08I01 496:F88L08Y03 497:T73V18L08 498:A70S16T13 499:L83T08V04I03 500:L57I42 501:A59V22L09T03G01I01S01 502:H91Q08 504:C93A04S01 505:N47H22R09K08S04T03D01L01 506:I55F44 507:T68K14A06S06E03 508:A55T21S09P06V03D01G01 509:D44-19H18N09S08 510:P80-19 511:A44E36K09D04N03L01 512:R34K26E16S11V09T01

513:P45T24S11E08D03A01L01M01Q01 514:P63L22V09E01T01 515:T54K22S08N04V04P03I01

516:L77M18I04 517:D73E18G08 518:Y78S13C04F01G01 519:T27N26S13K11E04H04V04L03M01Q01 524:L91M08 527:H50K24N14L03R03C01T01 528:A52P18D11N11T03G01S01 529:F63Y36 530:-91E08 531:S39K16V16A09H08T03Y03F01N01 532:I68V22L08 533:A73S22H01N01 534:V98L01

535:T50S42A03E01N01 536:L72P11V08A04H03 537:R98L01

(x) N29

1:-98M01 2:-97A02 3:-96M01T01 4:-92M05G01 5:-88M07P02 6:-88K02E01N01T01W01 7:-85A06M03l02 8:- 77M11A06V01D01 11:-98F01 12:-98G01 13:-98V01 14:-98K01 15:-98G01 16:-98S01 17:- 73M09F07L04P01S01 18:-63S21M09W01A01V01 19:-62V10A08L08M04Q02P02 20:- 56L14F09V06M05A03Y02 21:-55G21S10L06E01R01V01 22:-45S14L13F12Q08M04 23:- 42P19S16Q07A05L02G01R01 24:-30l20V12G10L08S05T03A02M02Y01N01 25:P32-26S21I07A05F03L02 26:I34V19F16-10M06Q05L02T01S01 27:S82-07M04L02T01 28:A81V11-02T02 29:T84S05M03-02P01 30:E96- 01 31:L58V25I07F05A01-01 32:L95-01 33:L83I10V04-01 34:A85V08T02S01-01 35:S57A29T04L02-01V01I01 36:A73T11V07-02F01S01 37:I43V40T09A04-01 38:F96L01-01 39:C95-01F01 40:L92I04-01

41:V77I07L04G03M02T02-01 42:F78L17-01 43:W63L26M05-01 44:V68L24A02I02 45:V49I32L10T03F02A01 46:R64Q25K07 47:A50S30T08G03R02 48:W35L28S16F11R03T03-01 49:R55Q34K04S01W01

50:P52Q34T06S03 51:R47Q22H20W03P02K01 52:V83I10L03A01 53:P97R01 54:K85Q06E02P01H01 55:G97K01 56:L96R01 57:K92R06 58:S75R14N07T01 59:P90L07I01 61:G90E09 63:W64R33F01

64:G91S05A01P01 65:W60Y27L07F03 67:L66I21V05F04M01 68:L60I38 70:H52N45S02 71:V71M18I04L03A02 73:T61E33Q02M01 74:L97V01 75:G71R28 76:K93S03R02 77:N59D26S10T02Q01 78:P85T14 80:L92V07 81:A60V21S13T04 83:T52S38A08 84:R74K12Q11 85:L75M24 86:S96R02 87:Q82R07K05A02E01

88:R46K33Q16 92:V98I01 93:L56M40F02 94:Q68E28 95:I71V28 96:R81H08Q03T02K01S01 97:I95L03 99:S50T29C16M01 100:T63R34 101:P98Q01 103:L74V25 106:S98N01 109:D84E10N03 110:T98A01 111:I93V05 112:R73K25 113:Q97K01 117:R58K35Q05 119:G93A05 120:D60E37N01 121:D97E01

123:K63M32A02 127:D96N02 128:L93F06 129Ύ83Η12Ρ02 130:S93T06 131:F94S04

132:T57R19Q12S05H02K01N01 133:L54F16Y14H13N01 134:I67V32 135:T43S33A16G03I01

136:D66N28E02G01 138:Q87K07H02E02 140:M61L37 141:T62A22S14 143:S55N40G03 144:P84T10R01Y01 145:D96E01N01 146:S93T02C02Y01 148:P62E36D01 149:V93A02R01 151:A62K26R09 152:A96L01

153:R97H01 155:R62K36 156197101 159:N84D08S05 160:A93G05 162:K75N21R01 163:T48S47N02 165:S98A01 166:I68V16T08L02M01S01 167:A86S09T01G01 168:S63P29A03E01 169:D60S37N01

170:P96K01L01 171:A46T38N04G03-03S02 172:S93A03 173:S79A09L03T02V02 174:S88C07T01

175:S69T28I01 177:Y63L34 180:E90D06M02 182:V96I02 183:S87T03R02I01K01N01 184:K91Q02T01N01R01 186:A98V01 187:E64D22N05S02K02Q01 188:Y53A27H08V07C01 190:I39V39L20

191:S41T28G 15R04N03K02I01Q01 192:K78R17T02 193:F68L31 194:Q62L35 195:E55Q33K08D01

196:L78Q11V06R01 197:M96-01S01T01 198:A55E24D06S06K03-01T01 199:E53G35K05R01

200:V27E21P21K12A09G02S02T01Q01 201:G65K29Q03 202:H37R28S26C04 204:D85E07N06

205:P89L08A01 206:Y75N09F04V04T01C01H01 207:R56N17S09Q08K03G02D02 208:Y67Q21H07E01 209:V60L28I06M03 210:V90L06M01T01 211:V77L06E04A03I02G01M01 212:S98A01 214:A91T04V02 215:N94K03S01 217:I98V01 218:C64G30S03 220:M75I22 224:K44Q39R12N01H01 225:R69H24N05 226:Y68F30 227:D60P28E04S03N01 228:H68Q22E03R03 229:D38N26S22E04K03R01T01 230:D50S29N 10H09 231:Q65E24K04D03 233:L68M27F03 234:L96V02 235:S77N13D03R02P01 236:L53I35V10M01 237:V79I 16L03 238:N60K18D04E04R02S02M01T01G01H01 239:L51N16S14V09E01M01T01 240:S57N25T11G03V01 241:N55H19E12D05K02S01T01 242:E66D18Q06N04K02 244:G55V35T03A01 245:E69D22N03K02

246:V57T19S05N04I04A04G01M01 247:A69V16T13 248:A54S25G 14T04 249:S86A09 250:G98A01

251:N86S05Y05H02 252:P92A03L03 253:A56V37S01T01L01 256:I62F35L01 258:I56V29L10F02W01 260:R59Q33K07 262:L91M04F02 264:N63S34 265:P42R33S16T05 266:-98V01 269:A49T26S16G02N01P01 270:L62M37 271:Q34D24K17N09E04S04T02R01A01 272:R27L26A14K07I06T04V04F03G02S01 273:F96Y03 274:K92I03M02L01 275:D62A12S08E07N05Q01T01 276:F47L35I 12V03 278:K31Q30R18E11D03T02 279:R62K32N02Y01T01 280:F89L07I02 281:L30Y25N 13V12S08I01M01H01

282:S25R14Q14H07I07L06A06V04F03N02D02K02 283:F92L05S01 284:L47V22M21I05T02

285:Q86R06E02K01H01 286:K91D02N02R01 287:I41M25T20L07R01A01K01 288:V87I 10L02

289:K52Q44E01R01 290:E95N01K01 291:H98C01 293:Q26K26E14R13T12S03 294:T49D29S17K01

295:F88Y11 296:D58E35N04 297:K87E10P01 298:N38G33E 13D07S05R01 299:H48S25N18R03V01

300:I81V18 302:R69Q30 304:I94V05 305:T92V04I01 306:D68G28S02 307:S67A31 308:L98F01 309:I68F23L07 310:E57K34G03A01 311:H80Q16Y01 312:C63S25N04Y02V01 313:Q55E26L09K04M01 314:E39D35K18N03 315:K56G 14N10S07R06D01Y01 316:K38S32R15P05Q05 317:L33V23R21A03D03T02Q02-01G01M01I01K01 318:D36A22G 14E14N02V02T01-01S01 319:E48S19A12-06N04G03T02D01V01 320:N51-31D12S01 321:- 98G01 322:-98E01 323:A51-32T10S02V01 324:N42G24A12H07R05S04D01

325:I35V19G19T08D05R02M01N01P01A01 326:Q56L22P08H06A01 327:L51I41M02V02P01 328:S53P44L01 329:D38Q21K14N12H06E03 330:E80K08D03Q03G02 331:K93N01S01H01Q01 332:I89T06V04 333:V66I32 334:N78S13T03H02G01 335:L44I33V20T01 336:V90I09 337:N63L20M05F03I02S02Y01T01 339:L70I29 341:G97A02 345:D97E02 346:T94P03S01 347:V82I17 348:T92A06S01 350:A92G04T01S01 351:I60L38 352:S94T03Q01 354:S93C03G01V01 355:L94I04 356:M76L18I02 357:Y96L03 358:L85V10A03

359:V84A13M01 360:T77L13M03K02A02S01 361:N38Y34K10S09R03H01W01

363:E29D22R17N14S06K04G02H02 364:I64V31M02 366:K53R42E01 367:K91R07 368:I97V02 369:Q91H08 370:E77K17A02Q01 372:L97I02 374:T56Q29R08A02E01 375:V64T30I01 376:I92V05T02 378:R81Q14S01W01 379:E42A37D08S04G02V02 381:R62Q26W04K02L01 383:R93Q04 384:L96F02 385:S93A02T01E01

387:R98K01 388:P52G24S11L08A01 389:Q57T19M 10H04N01L01 392:Y97L01 393:T35L34M29 395:A98S01 396:F97V01 398:L97H01 400:T44M31I 12V07L03 401:F96Y03 403:H95Y04 404:S83T13A03 406:F97L01 407:V53L39I04M02 411:I97L01V01 414:S88C10 416:T95I03V01 417:R69K30 418:D84A13N01

420:S31V29T27A05N04I01 422:N76K11S08C01 424:F64Y35 425:Y88F07H03 429:G35D33E27K02N01 430:R64T16C07L07H03 431:C96V01 432:V93I06 434:V61I38 435:N98S01 438:Q95H03S01 439:V67I30 443:Q39E38P19R01 444:K81E09T03Q02S01 445:L85V07Q05I02 447:G42K35E10D05V04P01 448:D88N06E04 450:S66F16L07N02E02D01Q01 451:E50T21A13V06K03S02 453:R57N29L04D02K01W01Q01 458:L98I01 459:T58N24S10A01D01 460:A59P18S05L04T04D03E02N01 461:D51E11A10N08S06G03T02H02K01 462:G91N04D03 463:T61-32S02 464:T33E31A25S03K02G01 465:I66V24L09 466:N73D16S09 467:K80R18 468:T39A27V17P04I03E02F01N01 469:L60E21D13A02 470:S78G 15A03T02 471:E84D14 472:K97Q01 473:V90I04M04 474:M39I31L25T02V02 475:L50I 18V11T07A06M02S02 477:G98S01 478:L67M31

480:K98R01 482:R61K37 484:I95L04 487:T40V22S15P06I05N04A01L01E01 488:I67L24P04M03 489:A71G28 490:R71K27 491:W73L18S02M02F01 492:E89Q10 493:V78I20M01 498:A73T14S11 499:I63T35

500:L90M08I01 502:Q95H04 503:Q80R16H01 504:L69V22I04M02C01 505:E95H01K01

507:S88R03N02K01T01H01 508:V77L14I05S01 509:P45S16C14R12T06L02A01

510:P63D17A06L02Q02E01N01S01 511:G97K01 512:V49E20K10T07Q04M02L01G01

513:K78E12R02Q02P01T01 514:V94A02L02 516:M50L33I 14 517:T97D01 518:P98S01

519:I51Q18L13T09V01N01H01 520:Y98F01 523:T85S11 524:M84L12I01V01 526:H73Y15P09

527:A42K34P11T06G01 528:R64K12H07C04P03I02T01Q01S01N01 529:C97F01Y01 530:E87K06Q02D01 531:H82C10Y01A01S01 532:F66V25L03I03 533:Q97S01 534:V40A36I 14M06-01 535:R34K33Q20H06W02- 01T01 536:L29Q19P15M 13K11V05-01T01 537:R98-01

(xi) N45

1:-98M01 2:-97A02 3:-97T02 4:-95M04 5:-93M06 6:-93N03W01T01 7:-89M05l03S01 8:-77M 17D01A01V01 9:-98T01 10:-98L01 11:-98F01 12:-98G01 13:-98V01 14:-98K01 15:-98G01 16:-98S01 17:-77F10L06P02S01 18:-61S23M 14 19:-59V16A12M06L02 20:-51L19F13M08Y03A01S01 21:-49G 18S13L09R02V01E01F01M01 22:-33L20F18Q13M06S05W01 23:-30S25P22A08L03G02Q02R01F01 24:I31V18L13- 12S06T04M03A02Y02N02 25:P48S31-11F04I02 26:I35F25M09-09Q08L02T02S02V02P01 27:S79M07- 04L04T02W01 28:A87V06T03-02 29:T86M05S03-02P01V01 30:E98D01 31:L87F08V02I01 33:L96V03 34:A93V02T02S01 35:S78A09T05V02I02L01 36:A69T16V10F02S02 37:I63V25T10A01 38:F97L02 40:L91I07 41:V87G04I03M02 42:F80L18 43:W95L03Y01 44:V94A01I01L01M01 45:V73I13L07F03A01 46:R86K09T01 47:A76T09G05S05V01 48:W54S24L11T04F02-01Y01 49:R50Q37K06S02W02 50:P77T09S05Q04

51:R69Q20W04K02G01 52:V90L04I03A01 53:P97R01 54:K91Q07 55:G97K01 56:L96R01 58:S86N08R03T01 59:P98L01 61:G86E13 63:W96F01R01 64:G87S07A02P01 65:W92L06Y01 67187F07I03V02 68:L53I45 70:H79N20 71:V67M22I05L02A01 73:T93Q02M01E01 74:L98V01 75:G97R02 77:N77S16T03Q01 80:L88V11 81:A70S14V13T01 83:S59T29A11 84:R73K16Q08 85:L77M22 86:S96R03 87:Q84K07A03E02R01

88:R65Q23K07H01C01L01 92:V98I01 93:L86M09F04 94:Q92E05T01 95:I92V07 96:R84H11Q02K01 97:I94L04 99:S70C25T02 100:T95 03I01 101:P98Q01 103:L66V33 106:S97N01 107:G97R01S01 108:L95Y01M01V01 109:D88E05N04 110:T97A01 111:I91V08 112:R89K08 113:Q97E01 117:R82K08Q08 119:G95A03S01 120:D89E08N02 123:K96A02 127:D96N03 128:L90F09 129Ύ98Η01 130:S91T08 131:F93S06

132:T86S07Q03N01 133:L82F16 134:I75V24 135:T53S32A08G01I01M01 136:D67N25E03G02

138:Q85K09E01H01 140:M92L06 141:T72S20A05 143:N61S34G03 144:P93T05 145:D97N02

146:S94Y02C01T01 148:P94E05 149:V94R01A01L01 151:A95K02V01R01 152:A96L02 153:R96H02

155:R93K04H01 156:L98I01 158:Q97L01M01 159:N83D12S02K01 160:A90G08 162:K64N32R02

163:S66T30N01A01 166:I69V12T11L03M02 167:A94S03G01 168:S95E01 169:D92S05N02 170:P97K02 171:A71T14G05S03-03N01 172:S97L01 173:S70A13L05T04V03M01 174:S87C07T02F01 175:S96T02 176:C98- 01 177:Y96L02P01 178:L98I01 180:E86D08M03K01 181:H98R01 182:V97A01I01

183:S83R04T02I02K01N01Q01C01 184:K93Q02R02 187:E86N06K03Q02D01 188:A41Y30H11V11C01E01F01 190:I55L31V12 191:S60G23N05K03T02R01Q01 192:K66R27T04A01V01 193:F60L39 194:Q93L04M01 195:E82K13Q02D01 196:L77Q16R02-01A01 197:M95S02-01T01 198:A83S09E02-01K01T01

199:G53E33K06R02A01S01 200:V41P32A14S03K02T02G02 201:G97Q01 202:H56R29C06S02P01A01G01 204:D83E08N07 206:Y84V06F03T02H01S01 207:R48N25S12K04G03D03 208:Y50Q32H12E02L01

209:V82I08L05M02 210:V86L09M02T02 211:V69L10E06A06G02M02S01 212:S97A01 214:A88T06V03C01 215:N91K05S01R01 217:I97V02 218:C48G46S04 219:A98V01 220:M73I24 224:Q59K19R18H02

225:R54H35N08L01 226:Y53F46 227:D51P44S02 228:H53Q34E05R05 229:D43S33N09K05R02T01E01-01 230:S45D26H 14N14 231:Q48E36K07D05 233:L51M41F05K01 234:L94V03 235:S83N06D03P01T01R01 236:L68I28V02 237:V70I24L04 238:N44K28E07D05R03M02S02T02G01H01 239:L52N24S18T01G01H01 240:S70N18T09G01 241:N60H28D04K03S02 242:E63D25N07K01 244:G50V46A01 245:E91K03D02N01 246:V38T28S08N07I06A04G02M01 247:A60V23T15 248:S38A36G 15T07I01 249:S95A02N01T01 250:G97A01 251:N83S08Y07 252:P91A06L02 253:V54A39L01S01M01 256:F53I43L02 258:I83V11F03W01 259:L96F01M01 260:R76Q11K10 262:L88M07F02I01 264:N88S08R01T01 265:P64S23T08R02 266:-98V01 267:-98R01 268:- 98S01 269:A63S17T09G04P01K01 270:L93M06 271:Q41D32N10K09R02S01T01

272:R40A19K06T06L05V05F04I04G03N01S01D01 273:F95Y04 274:K97M01R01

275:D51A18S13N07E04Q02T02 276:L49F47V02 278:Q44K25E16R06D05N01 279:R48K46N03T01

280:F87L09I03 281:Y38L28V17S05N03H01F01R01 282:S25Q20R18I 11V06L06N04D02A01K01 283:F97S01 284:L46M32V09I06T04 285:Q84R09K02H01 286:K95N02I01 287:M34T30I 19L11K01 288:V82I 14L02 289:K51Q45R01 290:E96K01 291:H97C01 292:Y96N01R01 293:Q40K39R19 294:T49D45K02N01 295:F97Y02 296:E48D45N05 297:K84E12P01 298:G50N39S06R01D01 299:H47S38R05N03V01C01 300:I72V27 301:- 98P01 302:R53Q46 304:I97V02 305:T88V06I02A01 306:D52G43S03 307:S50A48C01 308:L98F01

309:I52F35L11 310:K51E44A02 311:H97Y01 312:C52S31N07Y04V01R01T01 313:Q52E39K07

314:D47K27E17N06 315:K43G22S10N09R09D02Y01 316:S32K26R23P07Q07

317:L49R32D05Q03G02K01V01T01 318:D51A33N04V02T02S02P01 319:E50S29-07N06G03D02 320:N52-46 321:-98G01 322:-98E01 323:A49-48S01 324:N52G37S06A01D01 325:I40G29V11D07R04N02P02S01 326:Q48L34H09A02R01F01K01 327:L49I43M03V02 328:S55P41L02 329:D50Q33H09E04R01

330:E78K11D05Q02 331:K94H01Q01N01 332:I84T09V05 333:V74I25 334:N79S13T04G01 335:L39V30I28T02 336:V85I14 337:N48L30M07F04I03S02T02 339:L60I39 341:G96A03 344:F98L01 345:D96E03 346:T93P05S01 347:V75I24 348:T97S01A01 350:A97T01 351:I91L06 352:S92T04Q02 354:S94C02V01G01 355:L94I04F01 356:M68L26I03 357:Y93L06 359:V98M01 360:T88M04A03K03 361:N56K16S14R04Y03W02

363:E39R26N12S09K06G04D01 364:I50V45M01K01 366:R63K31E02L01S01 367:K98R01 368:I96V03 369:Q91H08 370:E73K24Q01R01 372:L97I02 374:T85R07A03 376:I88V07T03 378:R95S02

379:A56E13D13S07G03V03 381:R45Q40W07L02K01P01Y01 383:R91Q06W01 384:L95F04

385:S91T02A02E02C01 387:R97K02 388:P71S14L11A01T01 389:Q88H07N02 392:Y97L01 393:L51M44T03 395:A98S01 396:F96V02S01 398:L96H02 400:T66I 18V07L04M01 401:F95Y04 403:H93Y06 404:S75T19A04 407:V78L15I05 411:I97V01L01 414:S96C03 416:T92I05V01 417:R88K11 418:D96A01N01

420:S46T41N07V03I01 422:N65K17S13C02G01R01 424:F96Y03 425:Y87F07H05 428:K97E01R01

429:G51E41D03K03 430:R78C11H04T03 431:C95V01Y01L01 432:V90I09 434:V66I33 435:N98S01

436:Q98M01 438:Q92H05S01 439Λ/53Ι45 443:Q59P28E08R01 444:K77E14Q03S01T01 445:L80V11Q07I01 447:G64E14D07V07K03P01 448:D89N09 450:S67F24N04D02 451:E77V09A07K04 453:R84L07N03W02Q01 458:L97I02 459:T86S05N02D01V01A01 460:A43P25S07L06T05D04E02N01V01

461:D65N12S08E03H03K02G01Y01 462:G86N06D04S01 463:-49T45S03 464:T50A39S04E02G01

465:I80V09L09 466:N71D23S03 467:K96R01S01 468:T37A33V12P06I04F01N01H01R01 469:L91A04Q01E01 470:S95T03 471:E95D03 472:K97Q01R01 473:V88M06I03F01 474:I47M39L08T03V01 475:L75I21M02 477:G98S01 478:L50M47A01 482:R55K43 484:I98L01 487:T49V34I07L02N02E01S01 488:I50L36P06M06 489:A81G 18 490:R59K39 491:W62L27M03F02S02 493:V79I 18M02 498:A97T01 499:I93T04 500:L97M02 502:Q92H07 503:Q74R23H01 504:L54V34I06M02C01 505:E97K02 507:S85R04K02N02H01T01E01

508:V91I04S01N01 509:P68S18T09L02 510:P75A09L04Q04D02S02R01 511:G96K01D01

512:V73T09E07M03L02 513:K91E03R01T01Q01 514:V95L03 515:D98V01 516:M49L49 517:T97D01 518:P97S01 519:I75T14L02N02V01A01Q01 520:Y98F01 523:T97S01 524:M91L04I02V01 526:H83P13Y02 527:A65P17T08K03G02Q01V01 528:R68H11C07P04I03T02S01N01 529:C97F01 530:E83K09Q04H01 531:H96Y01Q01 532:F50V38I04L04M01 533:Q97S01 534:A54V34M08-02 535:R48Q29H09K05W03-02T01 536:L44P21M20V08-02T01 537:R97-02

(xii) N46

1:-94M05 2:-94A05 3:-90M03T03A01 4:-81M 13G03 5:-74M16P07A01K01 6:-74K07N05E05S02Q01A01 7:- 73A16M06E01 8:-73A17D03V03E01M01 9:-97T02 10:-97L02 11:-96F03 12:-96G03 13:-96V03 14:-96K03 15:- 96G03 16:-96S03 17:-63M24L05A02I01 18:-63S21W04A03V03L01 19:-63L21Q06P05V01A01 20:- 63V18L10A05M01 21:-64G25E03S03M02 22:-64S35 23:-61Q16P13S06H01 24:-61G27T06S03A01 25:- 51I 17A14S07L06V01 26:V50I34-12L01 27:S84-10L03 28:A67V25-03S01T01 29:T78S14-03A01G01 30:E94-03 31:V70I 18A04-03L01M01 32:L87-03F02I02M01V01 33:L55l27V12-03 34:A67V19S04-03T01M01

35:A67S17L07-05T01 36:A80V07-06T03I01N01 37:V72A09T06l05-05 38:F92-03L03 39:C89-05F02L01S01 40:L89-05I05 41:V56I 15L13T06-05M02 42:F76L14-05S01V01 43:L73M 14-03I02T01V01 44:L64V23A03I03- 02F01 45:l66L18T09V03-02 46:Q69R24K02T02-01 47:S79R07T06W02-01P01 48:L61F29R07-01

49:R66Q28W02-01K01 50:Q90P03-02R01 51:H56Q23R08P06K02-01N01 52:V65I24L05A01-01T01

53:P94R03-01 54:K74E07Q05P04H02-01Y01 55:G93K03-01E01 56:L94R03-01 57:K80R16-01Q01 58:S50R38N07-01K01 59:P77L18I03 60:P98S01 61:G98E01 63:R92F03W01 64:G94P03S01 65:Y76L09F07W03I01 67:I56L25V13M04 68:L69I28V01 70:N92S07 71:V76M09L08A03I02 73:E92Q05D01 74:L96V02 75:R72G27 76:K82S10R05G01 77:D71N24Q03 78:P58T40 81:A39V32S17T10 83:T96A01N01 84:R73Q16K09E01 85:L67M32 86:S91R05G02 87:Q74R19K05 88:K85R09Q03E01 91:D98E01 92:V98I01 93:M94F05 94:E68Q25M01T01G01 95:V66I33 96:R71T06H05Q05K04S03W01A01 97:I94L04

99:T78S16M03A01 100:R94K02Q01 101:P95Q03R01 103:L84V15 106:S95N03G01 108:L96Y02

109:D73E23N01 110:T96A03 111:I97L01 112:K60R40 113:Q94E02K02 117:K87R12 119:G87A12 120:E92D05 121:D94E04V01 123:M89A05K01L01V01 127:D96-01 128:L94F03-01 129:Y56H32P05C01-01 130:S97-01T01 131:F97S01 132:R53Q34H06K03 133:Y40H35F20N03 134:I54V44 135:S38A30T23G07 136:D60N37

138:Q87K05H03E03 140:L92M07 141:A55T41G01S01 143:S94G04 144:P64T23R03Y03H01S01

145:D90E04N04 146:S86T04Y04C03 147:G98E01 148:E96D03 149:V89A03R03M02S01 151:K74R25 152:A93L03V01 153:R95H03 155:K96R03 156:L93I03V02 158:Q98R01 159:N88S11 162:K94R04N01 163:T83S11N03 165:S97A02 166:I62V21T06S04A01L01 167:A66S23T05G03L01 168:P81A09E03S01K01 170:P90K04L03S01 171:T85N11-01 172:S85A08T02C01 173:S91T03L01P01 174:S85C12-01 175:T72S21I03 177:L96P02 178:L94I02V02 181:H97R01 182:V92I05 183:S89T03Q02C01F01 184:K85T05N03Q02A01M01 186:A97V01 187:D59E22S07N03Q03A01 188:Y92H02E01F01 189:L98V01 190:V92I07

191:T74R09K05I03S03A01 192:K96A01V01 193:F80L20 194:L93Q04M01 195:Q87E10R01 196:L81V16Q01 197:M94S03-01 198:E63D18K08S03T01-01R01 199:E85K10-01Q01 200:E58K30G06Q03 201:K81Q10G05N01 202:S70R24A01P01 203:F96L02I01 204:D91E05N02 205:P72L23A02I01 206:Y57N27F05T04C02H01 207:R72Q23S02 208:Y96Q03 209:L67V18I06M05T02 210:V94T03 211:V93I06 212:S96A03

214:A94C01T01V01 218:C96S01 219:A97G02 220:M77I 19L01 224:K92N05R01 225:R98H01 226Ύ97Η02 227:D76E12S07N01T01 229:N54D31E10S01 230:D96N03 231:Q94K04E01 233:L95F04

235:S61N29R03D03K01 236:I47L25V23M02 237:V92I05 238:N90D03K01H01 239:L52V26S05E04M03I02A01 240:N38S30T16G09V03 241:N44E34D13H03T03 242:E72Q18D04K02 244:G67V12T09E01I01N01A01M01S01 245:D58E25N10K03 246:V90A04T04 247:A87T08V03 248:A85G 14 249:S67A25G02V02 251:N87H07S03 252:P90L09 253:A86V08S02T02 258:V61L26I06W03M01 259:L97M02 260:Q72R27 262:L94F05

264:S83N12R02 265:R87P06Q02H01S01 266:-96V03 267:-97R02 268:-97S02 269:T58A20S17N03

270:M92L06 271:K32Q23E11S09D07N07T03A03 272:L62K10I09A06T04V02M01S01 274:K80I09M06L03 275:D80E11Q05A01 276:F46I33L13V05 277:N98L01 278:K42R38Q07T05A02Y01 279:R90Y04K02S01 280:F91L07 281:N36L30S14I05M03D02V02G01T01 282:S24H21A13F10R07L06D05K03I01M01

283:F84L13Y01 284:V47L45I06 285:Q91E04H02 286:K84D07N02R02T02 287:I79M07R04A03K03N01 288:V96I01 289:K55Q39E03 290:E94N03D01 292:Y95R01L01 293:E40T34S09R06A02K02D01I01V01 294:T50S49 295:F69Y30 296:D85E09N03 297:K89E06P03 298:N37E36D18G05S01 299:H49N43V03S01Y01 300:I98V01 301:-98P01 304:I89V10 307:S96A01C01 308:L96F03 310:E80G 10A04D01Q01

311:H49Q44E02Y01 312:C82S11V03A01 313:Q63L26M03-02V02 314:E80D14-02K01 315:K83N09E01R01S01 316:K63S29N02-01T01 317:V65A09T05-05I03M03L03K01 318:G40E40Dll-03 319:E44A34T05-05D03V03G02 320:N50D34-05S05T01 321:-96G03 322:-96E03 323:A52T27S07V05-03G02 324:A30N26H19R14- 02S01C01V01 325:V33I27T23M04P03A03L02 326:Q70P22A03L01S01 327:L58I35P04V01 328:S50P47L01 329:K41N34D18E02S02 330:E84G07Q05K02 331:K87S04H03N02Q01 332:I98V01 333:V55I43M01

334:N71S16H07G02T01 335:L52I43T04 337:N90Y03T03G01S01 339:L89I 10 343:G97A01 346:T97S02 347:V92I07 348:T80A14S05 350:A82G 11T03S01 352:S94Q03 354:S88C07V03G01 355:L95I03

356:M89L07V01I01 358:L61V27A08I01 359:V58A36M02S01 360:T53L37K04S03 361Ύ92Η04Ν01

363:D61N17E12H06K01 364:193M02V02T01 366:K94R03E01 367:K80R19 368:I98V01 369:Q90H09 370:E84A06K03D02N01Q01 372:L93I06 374:Q81R12E03 375:T83V06I04N02R01 376:I98V01

378:R56Q38W03 379:E96D03 381:R91L03K03 384:L95F03 385:S94E03A01 388:G67P17S06A04L03 389:T53M29N04L03S02V01K01Q01 390:L98M01 392Ύ98Η01 393:T95M02 396:F97V02 398:L94H03 400:M85V06I04T03 404:S98T01 406:F93L03Y01 407:L81V10M06I01 410:T97A01 411:I95L03 414:S70C27-01 417:K67R30 418:D64A33 420:V80A14S03I01 421:L98F01 422:N98K01 424:Y96F03 425:Y87F11H01 426:I97V02 429:D89G06N03 430:T44R34L20 431:C96V03 434:V54I45 436:Q98M01 438:Q96S03 439:V97A01 443:E90P07K01 444:K84T07S03N02 445:L94I05 446:W98F01 447:K93P03E01 448:D87E12

450:S61L21E05Q04D03F01 451:T60A26S07K03R01 453:N81D06K05R04S01 455:E96K01

459:N65S20T03D02R02A01C01H01 460:A85P05E04T01D01 461:A29E26D24G07T05N04S01 463:T93K02- 01A01 464:E85K05G02R01T01 465:V50I37L12 466:N76S20D02 467:K49R47S02 468:T45V25A16E06D01M01 469:E58D36L02N01K01 470:S45G40A09T03 471:E62D37 473:V91I05F02 474:L54M41V03

475:V32T21A18I 14S06L03M02P01 478:L94A02M02 480:K94R05 482:R75K23 484:I89L10

487:S41T21P18N09A03E03 488:I95L03 489:A52G47 490:R94K05 491:W89M05S01G01 492:E70Q29 493:V72I23M04 498:T38S30A29V01 499:T95I03 500:L78M 18103 501:L98V01 503:Q92K02R02E01

504:L96C03 505:E89H04K03Q01 506:F96I02 507:S91K02N02E01T01 508:V48L39I06S03N01

509:C40R34S16A04Q01 510:D45P43E04N03G01 511:G94K03-01 512:E48K29Q11V02G01S01-01A01T01 513:K52E31R05Q04P03 514:V88A06L05 515:D96V01T01 516:M50I39L05V02 517:T95D03 518:P96S03 519:Q50L32I05T03H03R01V01 523:T66S29V01L01 524:M72L26 526:H52Y38P04N02F01 527:K95E01T01 528:R54K35Q03N03P01 529:C93F03Y03 530:E95D02K01 531:H59C27A04S04Y01 532:F93L05 533:Q94S03 534:V52I39A04M03 535:K85R08Q03T03 536:Q52K31P09L02R01

(xiii) N52

1:-96M03 2:-95A04 3:-95T04 4:-95M04 5:-95M04 6:-95N04 7:M87-12 8:A51V24-12M06D03P01 9:-97T02 10:-97L02 11:-96F03 12:-96G03 13:-96V03 14:-96K03 15:-96G03 16:-96S03 17:L85-14 18:M77A06T06S05- 01I01L01 19:I64V17M07L04D02S02-01 20:L94I02-01 21:P93E02M02-01 22:F55I22L11S05V03-01

23:I68L15V06S04F03-01 24:G91T06-01 25:S48P32A18 26:V51I25L23 27:S95L04 28:V93I04A02

29:S89L04T02C02 30:E95H03 31:S57G28V12 33:V81I14L04 34:A96S03 35:M45L26I 15V10A02

36:T34V33I 18A12 37:T86V08M02A01 38:V41L18I 16M13A06F02 40:L64V14I 12T06F02 41:V93I04A02 42:Y93F06 43:L84M 14 44:I49L31T08V04A02M02F01 45:L67M 18I08V02G01 46:K61R30T03Q02W02 47:F27L21Y17S10H09Q05N03V02 48:F53L15M 15K04T04A03S02 49:R36H34Q16N04S03W02Y02

50:T67R07K05Q04N04D03S02V02A01E01 51:E61K26R04D03Q02G01 52:I95L04 53:P95R03

54:E77A08K08G04 55:G95K03 56:L95R03 57:R49K21Q17S04H02L02C01 58:R59Q23K06P05N02L01 59:L91P08 63:K74T10S05R04F03Q01 64:P87A06S05 65:L81F10W04Y02 67:I83L12V04 71:V77L18I02M01 72:L91I05M02 73:E91Q04G02D01 74:V49L44I03M02 75:G83H07S02Y02A02 76:S45N22R10K06A06Q04- 01G01L01 77:N42K38R13Q03-01 78:P98-01 79Ύ57Η40-01 80:L97-01Q01 81:S98T01 83:T97S02

84:A68E18K07S03 86:S93R04 87:K76E18Q04 88:R85C05K04H02Q01 89:Y82F17 91:D44H20P17S10N04Q02 92:V94I05 93:F96Y02 94:Q95K02T02 95:I95V03 96:Q92H04K02 97:I92L06 99:M83T12S04 101:P96Q03 103:V93I04A02 106:S87G06N05 108:S46N28Y12L04G02I01M01T01 109:E88D10 110:T83V13A03

111:V83I13L02 112:R84K14 113:Q96E02 116:I77V08T07L05-01 117:K97E01 119:G97A02 120:E54D44-01 121:E58D41 123:A72S27 124:G94S05 128:L95F04 129Ύ95Η04 131:F93T04S02 132:R53Q26K16S02 133:F90Y08 135:N79S20 136:D73N12E11A02 140:L95M04 141:A89S06T04 144:T94S04 145:D95N04 146:Q75K16Y06H02 147:A83V10G06 148:G91E06N02 149:V82I 13R03 151:R95K04 152:A81T10L04G02H02 153:R94H04 155:K98R01 156197102 158:Y59M 13L12Q09H04 159:S81N18 163:S85T12F02 165:S76A23 166:T64S20N06I05-01 167:L81I06V06G03D01S01 168:E71D08K08Q08N02 169:G82S12D02-01

170:T51K18S17Q09P02-01 171:T67S16L07N06D02 172:P65S20A06G03L02 173:E87T05G02Q01 174:Y95C04 177:V42A34M 15L03P02T01 178:L97I02 180:E97M02 181:H97R02 182:I74V24 183:C63S32Q02L01 184:K93A01M01Q01 186:G57A28T10S02 187:E73L16Q04D02K02M01 188:Y81H12E02F02C01 190:I55V44 191:K76E14R03N02Q02 192:Q51R23E18A02K02V02 193:L90I05F03

194:N38H13S12T10Q06D04K03L03M02R02E02C01 195:T39S24N13E08K06G03D02 196:V90L05A02I01 197:M89S04T04L02 198:K57E14D10T05S04Q03R02 199:A61T15V14K05S02 200:D46E18S12N11K05G03 201:G96Q03 202:S70K14G04C02A02P02R02T02 204:D94E05 206:F89Y06T04 207:R97P02

208:H65Y26Q04N02 209:I96V03 210:V95T04 212:S95A03 214:A97C02 219:G93A06 220:M88I 10L01 224:R93K06 227:D61S34N03 229:D50N26H21 230:D90N06H03 231:Q79D09E04K04R01 233:L95F04 234:L69V30 235:S57G26N 14R02 236:L89F05I05 237:V95I04 238:N90T07K02 239:L88M 10 240:S87A08N04 241:D78E14H03N02 242:E80D18 244:G71V19N04S03M01 245:Q70K16R10N02 246:V88I06T03A01 247:V70A16T12 248:G81A10S08 249:S89N04A03T02 251:N95S03 252:P93L05 253:A95V03

258:I42A22F18V07L06W03 259:L91M08 260:R51Q48 261:Y57F28I06L04M02 262:L95F03 263:P97L02 264:S65N30R02 265:K31T26R21A06P05S04Q03 266:-96V03 267:-97R02 268:-97S02

269:T69S14A06K03D02N02 270:M93L04I02 271:K86R04Q03T03E02 272:K57T14R11N08A05S03

274:V36M35L18K03Q03I02 275:D43N24S12R06E04Q04A03G01 276:I84L12M02 277:N97L01

278:A35D26N14R08Q04T02E02K02G01S01V01 280:F95L04 281:N68T10S10I06Q02

282:T35N22K12S07E06A04V04D03Q02 283:F96L03 284:V87M06I06 285:Q92K06 286:K93R05N01 287:I85L10K03 289:S47T20R11K10N06G01 290:E97D02 292:Y95R02L01 293:A41T16E14D13R10I02 294:T82S16 295:F51Y48 296:D79N19 297:K95P03 298:D79N14G03E02 299:N94V03H02 301:-97P02 304:I97V02 307:S95A02C02 308:L96F03 310:D88A04N04E03 312:C96V03 313:E90Q08 314:D95E04 315:R91K08 317:L93V03-01K01 318:D98-01 319:E95D02-01 320:N97-01 321:-96G03 322:-96E03

323:S75A22C01 325:V52I34L06P04T02 326:Q93A04 327:M52V34I06L06 331:K95H03 332:I83V16

334:G91S07 335:I95T04 337:N96T03 339:L97I02 347:I79V20 348:S95T04 350:A87G07T03F02 351:L97M02 352:S95Q04 354:S65A29V03G01 355:V85L11I03 356:M66V24G04L04 358:L94F03M02 359:V96M02 360:A78S08T06K04V02 361:Y87H11 363:E88D10 364:I85V10M02L01 365:Q84E15 366:E87K09N03 367:R82K15 368:L91I06V02 369:Y36H34F20Q08 370:Q71E20R06 372:L59I32M08

373:K72D08E06R04N02M02T02 374:E65D21R04S03V02N02 375:K44N31T06Q06V06S03 376:V78I21 377:G95D03 378:L58M24R08N02Q02T02P01 379:D73E10I08N08 381:T69M10L05N04S03K02R02

383:R39L18V16T14C08S02 384:L89F07I02M01 385:S77A06T04E04C02L02V02 387:K56R43

388:P39N22T14S08A06I06 389:N80K06S04D03E02R01 391:P96I02 392:L49F33Y14 393:L91T08 394:E96D03 395:A89S10 396:F93Y03V02 398:L90T04H04 400:I67L20M04T02V02S01 401:F91L08 406:F86Y13

407:L91V06M02 411:I97L02 414:C96S03 415:T87S11 416:T61S27I08V01 417:K95R04 418:D94N05

420:S88A05V05 421:L98F01 424:Y93F06 425:F90Y08 428:K97N02 429:D92N04G02 431:C96V03 432:V97I02 434:I84V15 436:Q97M02 438:Q96S03 439:I62V35T01 441:H97R01 444:E79K07S04A03D02T02

445:L87Q05I02V02M01 446:W98F01 447:K81E09Q04P03 448:D74E25 450:S89F04D04T02

451:S78L07A03M03K02D02T01 453:N79I07S07K03L02 454:P97I02 455:D80E19458:L97V02

459:S61N27T06D04 460:A77E10D08T01 461:D93N04E01 463:T84S08V03M02I01 464:E85T06D04S02G01 465:V58L32I09 466:N98K01 467:K88R08S02 468:L56M19T09V08A02I01Q01 469:E79D14L03K02

470:G81A11T04S02 471:E96D03 473:V90M06F02 474:M68L25V03T02 475:V52I18T11A10L04M02P01 478:M53L42A02 479:G95D03 480:K90R09 484:I93V06487:V60A21S10E03I02Y02 488:I96L03 489:A67G32 491:N67S15A06M05H02T02 492:E98G01 493:V95M04 494:F59Y40 495:L95M04 498:A97T02 499:I90T05V04 500:L69I24M05 501:I59L26V14 503:K49R36N08Q06 504:L96C03 505:H33R20K19Q12E04N04C03S02 507:H31S15Q14Y14L09E07K05R01 508:E18S18A18T12P08K07N06G06Q03 509:L32M32K14I08S06V02P02 510:P97G01 511:G95K03 512:E63Q19H12D03 513:P59M14E07K06Q03L02A02T02 514:L75P11V11M02 515:D96V02T01 516:M81L18 517:T96D03 518:P96S03 519:E91T04N02Q02 526:H93P04N02 527:K95-02S02 528:R90-02N02D02P02 529:C91F03-02Y01 530:-95E04 531:H44Q26L09Y06-05F02N02R02M01 532:L85- 08V04 533:R53K17-08G07S06Q03C02 534:A73V16-08 535:T48S28-08A08K03R02 536:M45L25P14-08A04V02 537:R84-09Q05

(xiv) N53

1:-80M20 2:-32M32A24R04V04W04 3:-32G28T28A04R04S04 4:M36-24L24V08P04T04 5:M40- 20I20K08R08L04 6:L44N24-20M12 7:S32M24-20T08V08A04F04 8:G36-20D20A12V08F04 9:-84T16 10:-84L16 11:-80F20 12:-80G20 13:-80V20 14:-80K20 15:-80G20 16:-80S20 17:L28-20Y16T12G08C04I04K04R04 18:L40S28M20-04I04V04 19:S36L28F20P08-04N04 20:L52I20A12T08-04P04 21:K40E28M16-04A04L04T04 22:E44S28D20-04N04 23:S52N20G 12-04D04F04I04 24:S44T32L08P08-04Q04 25:S80F08-04C04H04 26:I40A32T20G04M04 27:S48L24P20A08 28:L68V24F04T04 29:S96C04 30:S44E36D12G08 32:T76L24 33:V80F08L08M04 34:A48V28S20I04 35:L88A12 36:C60V24F16 37:L44V32A20T04 38:L52F40I08

39:T48C24V12A08I04N04 40:L60I28V12 41:I52L44G04 42:L72F28 43:L48M44I04V04 44:A72V28

45:I48L48V04 46:R72T16H04V04W04 47:S40G32V20A04C04 48:R48L28K20Q04 49:K40R28Q20W12 50:S52Q24N16R08 51:H32R32A16E08K04Q04V04 52:D36-28L28G04N04 53:R36H28-12D12G04N04V04 54:T44K40-04A04P04S04 55:K72D16-04A04G04 56:F36R24V16Y08-04A04G04L04 57:P56K32-04N04T04 58:S52N16R08T08H04L04P04V04 59:P88A12 63:T36F20K20R20N04 64:P84S16 66:P96A04 67:L48I28V24 68:V60I40 71:L88M08F04 72192F08 74:L36M36V28 75:G96E04 76:D48K24E20N08 77:Q84H08Y08 78:P40I32M24V04 80:L96I0484:K44R40G04L04N04Q04 85:L60M40 86:R80G20

87:L40K28M12E08A04R04V04 88:Q56K40I04 89Ύ96Η04 92:V96I04 94:K44Q44T12 95:M44I36V12L08 96:R52K36H12 97:L60F20M20 99:S88M08T04 100:L68R24V08 101:T36P24Q20V16L04 104:V80I20 106:S76N24 108:Y76I08L08-04H04 109:E32N32S16A08D08T04 110:T80A20 111:I96V04 112:R52K48 113:Q80E20 117:R68K32 118:Q96H04 119:G88A12 120:E96D04 121:D48A36S12N04 127:D60E36N04 128:L68F32 129:F64Y36 130:T72S24I04 132:S76Q24 133:A64F28L08 134:V60I40 135:A64S28G08

136:N76D24 138:T68K32 141:T80A20 143:S96N04 144:E76T20-04 145:K68N32 146:Y96F04 148:P52E48 149:A56R20S20V04 151:L40K32V16I04M04T04 154:K76R24 155:K92R08 156:L64I36 157:C64A36

158:K76Q24 163:S52T48 165:S96T04 166:Q68T24K04R04 167:A52G20T20S08 168:E88K08A04

169:P56S28A16 170:R52K40Q08 171:G48T24N12S08D04E04 172:S88-04F04P04 173:G44T36D08N08-04 174:A56C40T04 175:T52S48 177:L88P12 178:L84I 16 181:H64Q20R16 182:V64I32M04 183:C84Q16 184:A72M08Q08F04T04V04 187:A52Q24T12S08I04 188:E76F12G08D04 189:M64L36 190:V96L04 191:E52K36G04Q04T04 192:V72A16M08T04 193:I48L48M04 194:R44L20M20W08K04Y04 195:E96A04 196:L40Q40E 12H04K04 197:S52A36G04P04V04 198:A44S28E24C04 199:K88A08E04

200:E40G20N16K08S08F04V04 201:G24E20Q20H12D08N08R04S04 202:G64A24P12 203:I44F36L16V04 206:V40T36A24 207:I32R24V20E08G04K04Q04T04 208:P44Q24S24L04T04 209:L56I40V04 210:V64T36 211:T60V28S12 212:S68A20T12 214:A88C12 217:V64I36 219:A96T04 220:L84I 16 224:K80R20 227:D96S04 228:H60Y36-04 229:N68D20S08-04 231:K96Q04 235:T68N32 236:I80L20 237:V72I28

238:N48H32K12D04Q04 239:I68L24V08 241:N64D28H08 243:V72F28 244:L64M20G 16 245:K48R36N16 246:L40I20T20A16V04 247:F72A28 248:A80G20 249:A84S16 251:N76S20T04 252:L84M 16 253:A80V20 256:F72I28 258:V60I20W20 259:F76M 16L08 262:F64L36 264:S84R16 265:P96L04 266:-80V20 267:-84R16 268:-84S16 269:S96G04 271:R64Q20K16 272:K60T20A08S08E04 273:M52F24L20I04 274:V64K16M 12108 275:Q96E04 276:Y36L24F20H16C04 277:I72N16L08V04 278:Q52H20R16E04N04S04 280:M68L32

282:G40D20N20S16R04 284:M68I28L04 285:E48Q24A16K12 286:R64K32H04 287:N52R24K20S04 288:I72V28 289:E56K28Q12M04 292:I40L28Y16R12M04 293:N40R24T20D04E04H04V04 294:T96N04 295:F80Y20 297:K76P20T04 298:N76G20D04 299:C60V20H08Y08R04 301:-88P12 304:I88V12 307:A88C12 308:L80F20 311:L72H24M04 312:C80V20 313:E64Q32D04 314:D68E28G04 315:R72K28 316:E44K36Q16H04 317:E60V16K12-08T04 318:D48N32-08S08E04 319:K32D20R16-08H08E04G04Q04S04 320:D48N24E16- 08K04 321:-80G20 322:-80E20 323:-80S20 324:T48N40M04P04S04 325:S44P28A24C04 326:L40A28V24M08 328:S88T12 329:N60D36K04 330:S52E36D04K04T04 331:Q80H20 333:I52V48 334:H60S36N04 335:T88S12 337:I60T20N16V04 339:I88L12 341:G96S04 348:I72S20T08 349:A60T40 350:G72T16A12 354:S72V20C08 359:I76M 16V08 360:K88Q12 361:F60Y40 363:D60E36N04 364:I92V08 366:D52E12K12T12A04R04V04 367:K84R08E04H04 368:I76V24 369:H48Q48V04 370:Q72E28 374:E52D24R20N04 375:H52V24K16Q08 376:I92V08 378:S60R24I04K04M04P04 379:A52D28S12N04P04 380:R96Q04 381:L96M04

383:R76G12M04N04Q04 385:E52S36A04K04P04 386:D96N04 387:K52R48 388:P72A24S04 389:N56K40S04 390:M68L32 392:F52Y48 395:A96S04 396:F84V16 397:I92L04M04 398:Y32H24F20N20S04 400:V72I28 404:S44A28T28 405:S96A04 406:Y72F28 407:V96M04 411:I88L12 414:C80S20 417:R44K36E12Q08 418:D60N36H04 419:T64I36 420:T40I36V24 421:L88F12 428:K96R04 429:D80G 16N04 431:C80V20 434:I68V32 436:Q88M 12 437:Y76W24 438:Q80S20 443:I32P24V20E12D04K04L04 444:D56S20T12A08E04 445:L96I04 446:W92F08 447:G56K20P20D04 450:D60E40 451:K60L12A08Q04R04S04T04V04

453:R68N24C04Q04 455:E64Q20A04D04H04R04 458:L88Q12 459:G52D32N12T04 460:E40P32K12S08H04L04 461:S52N36C04E04L04 463:-76T24 464:Q52E32L12H04 465:L96S04 467:K84S16 468:E44D24T24S08 469:L92K08 471:E76D24 473:V84F16 474:M52L44Q04 475:I84L08P08

478:M56L20A16V08 480:K96I04 484:L76I24 486:D68E32 487:G56E24N12D08 488:F56L24I16V04

491:L72M28 495:V60L24I16498:T76A24 502:H72Q28 503:G36Q36R28 504:L72C20F04T04

505:R52K36C04H04Q04 506:I72F24L04 507:E80K20 508:N80S20 509:V64S28L08 510:P96H04 511:G80K20 512:Q80E20 513:E88K08Q04 515:D80V12T08 517:S60D20T12G04N04 518:T52S24P16A08 519:D60T32N08 520:F56Y44 526:P96-04 527:R56K36-04H04 528:P80N16-04 529:Y76F20-04 530:-76E24 531:R56H28K12-04 532:l68L28-04 533:T52S28Q08-04K04M04 534:V76l l2A08-04 535:S64T20K08-04I04 536:P56S28Q12-04 537:R96-04

(xv) N58

1:-92M07 2:-90A09 3:-90T09 4:-90M09 5:-85M12V01 6:-85N09M03W01 7:-85M09V04 8:-85D07A04Y01 9:- 93T06 10:-93L06 11:-92F07 12:-92G07 13:-92V07 14:-92K07 15:-92G07 16:-92S07 17:-85L12F01 18:-85S14 19:-85L14 20:M73-14L11F01 21:I60M19-11E06T01V01 22:F38L34S14-11V01 23:D39N23S15-11H06G01V01 24:L42M15T14K11-07I06S01 25:A68S11E09-07T01V01 26:V57I31-06A01M01T01 27:T71L07- 06S06I03A01N01V01 28:P63S09V09-06L06A04 29:G60S14E12-06K04R01 30:E93-06 31:V88-06A03L01 32:T79L09-06A03I01 33:T68V12I07-06A03F01 34:S84-06A06C01T01 35:L85-06A04F01R01 36:I61V11L09- 06T06F04 37:I60V30-06M01T01 38:L90-06F03 39:V77C09-06M03A01L01 40:M47I44-06V01 41:V73I19- 06A01 42:F90-06L03 43:V71L12l09-06 44:F76V09-06A03S03L01 45:V66ll5Lll-0646:R82-06T06K03N01 47:A65S11V07-06E04T03G01 48:L92-06R01 49:R39G38M11-06W04 50:S60N23Q09-06 51:K68R26-03Q01 52:-88Lll 53:G69R14-04N04S03D01E01 54:R63K19G11-04Q01 55:K85R09-04 56:Q65R12H07- 04E04I01K01P01 57:V53L15K11M06P04G03-01I01R01 58:S80F06N06R03A01P01 59:P88L11 60:P98A01 61:G98S01 63:W79F07R07-03L01 64:S82P14A03 65:F76L12W11 66:P98S01 67:I82V09L07 68:I90V07L01 69:G93E04Q01 72:L90P04F03R01 74:L96I01P01 76:D66E20K09A03 77:H90Q07Y01 78:P98L01 79:Y77H14F07 81:T82S15M01 82:F63L36 83:M73T20I06 84:E88K11 86:R93K04S01 87:K98R01 88:K98Q01 89:Y95-03C01 90:G96-03 91:D96-03 92:V95-03I01 94:L85Q07T04M01 95:I63L33V03 96:K80R14H04 97:L98F01

99:M80S07V06T03L01 100:V87R09E01L01 101:P92Q07 102:V98A01 103:V68L31 105:V85L11A01M01 106:N95S04 108:M77L06Y06T03-01A01I01V01 109:E98D01 110:M79T11A07P01 111:V88I11 112:K98R01 113:Q71H09E07K04-03R03 114:V82A11G04I01 116:L76V11H09A01F01 117:K93R04Q01 118:D80Q11N06E01 119:G92A04R01T01 121:H69N14D09K03L01Y01 122:F98Y01 123:A98P01 124:G95-03R01 125:R93-06 126:P95-03S01 127:N69D17K06H04A01 128:M82F12L04 129:H77Y17M03T01 130:T84S11C03F01

131:F95I03N01 132:S85Q09P03I01 133:F90V07Y01 134:L73F12I11M01V01 135:A82S15P01

136:E77N15G03D01W01 137:G92H03A01K01T01 138:K96M01N01 139:S95E03K01 140:L60F22M12E04 141:S85A07T06 142:F95Y04 143:S95A03V01 144:V79T09F04E03-01P01 145:N96H01S01 146:Y93-03C01F01 147:G98E01 148:E98D01 149:S87R07N04 151:K98T01 152:L96H01I01 153:H95Q04 154:K84R09-06 155:K96R03 156:I92L04M01N01 157:A98S01 158:S79Q09I06K03M01 159:N68K23S07 160:A98S01 162:R92- 03Q03K01 163:T87S09A01N01 164:F84L14S01 165:S98P01 166:K65N25T09 167:A84G07S06T01 168:E96K03 169:A88S09T01 171:S87T09A03 172:S98-01 173:T96-01S01 174:C98R01 176:C98S01 177:L90P04I03V01 178:L93I06 180:E96K03 181:H87Q07R04 182:V92I07 183:T58I20C09Q06A01L01V01 184:E82A07M03Q03G01S01 186:V80A17I01 187:S88Q09A01 188:E93F04V01 189:L96M03 190:V96I03 191:K71T23H01R01S01 192:V80I09A06F01L01 193:F82L17 194:A33V31T14L07-03M03E01G01K01S01 195:E87K07-03R01 196:L95-03S01 197:T61S34-03 198:S92L03A01Q01T01 199:K92E04T03

200:N58K19G07Q07S04R01 201:G88Q07D01S01 202:S69G 14A09P04N01 203:F96L03 204:D82E15N01 206:R80T14K04 207:N63S15G 11R09 208:A66Q09V09S07P04L01 209:I98L01 211:C84V12S03

212:A87T06V04S01 213:V95M04 214:A95C04 215:N98S01 216:V96I03 217:V85I 14 219:A93T04F01 220:L92I06F01 221:C98R01 226Ύ96-03 227:D84E14G01 228:H98-01 229:S66N14D09F04-01G01T01 230:D98N01 231:E80K15Q03 232:E96D01K01 234192107 235:R53K28N11S03Q01T01 236:I85L07V06 237:V73I25F01 238:K88N07Q01R01 239:T84L09I06 240:N95D04 241:D93E04H01 242:D73E26 243:L77F20I01 244:L87G06M06 245:K93N06 246:A90T07V01 247:S87A12 248:S84G07A04N01R01 249:A84V07S04I01P01 250:A80G 12V04S01 251:N92S07 252:P85L14 253:A88V09T01 254:D98N01 258:C82W07I04F01S01Y01 259:F65L28M06 260:R90H06C01W01 261:Y96H01S01 262:L90F09 263:P98I01 264:L84R06S06M03

265:R42Q33P17K03G01S01 266:-92V07 267:-93R06 268:-93S06 269:I77S12A04V03G01 270:I82L11V06 271:N82Q07K06H01R01 272:A82T07G06H01S01 273:P84F09L04S01 274:R79K07M04Q03F01L01W01 275:E77Q14K04S01V01 276:F87L09T01Y01 277:Y85N06I04L03 278:Q58R22H15C01Y01 279:A71R12Q07- 03M01V01Y01 280:L95P01V01Y01 281:N96S01Y01 282:Q36G23E11R09D07N06H01K01L01 283:F98Y01 284:I98L01 285:A71Q09T09E03F01K01M01S01 286:L68K12Q11R04G01S01 287:H80K07C03N03Q03I01 288:V96I01R01 289:Q82K11R03P01Y01 290:D80E17K01 291:H98I01 292:L66I 19Y09R04

293:T60A23R09K01L01S01V01 294:T93R03I01Q01 295:Y88F06H03C01 296:D98P01 297:K88P07E01Q01 298:D73N14G 12 299:H88V07C01Y01 300:I74M 14L09T01 301:-95P04 302:R95Q04 304:I95V04 307:A95C04 308:L90F07V01 309:I92V04F01L01 310:N74A12S11T01 311:T44V25I 12H09A04L03 312:C92V07

313:H80Q15R01Y01 314:N63D14KllE07-03 316:Y63K14H11N07R01S01 317:A82S06-03K03V03T01 318:A52T22DllS06V04-03 319:T69D09A07-03G03I03K01S01 320:K85N07-03E01Q01 321:-92G07 322:- 92E07 323:-92S07 324:T80N12-03A01I01 325:A53D22P15T04G01S01 326:T77A14I06S01

328:N71S22T03K01P01 329:D96E01N01 330:D57S25E11N06 331:E84H07Q04K01T01 332:I93V06

333:I85V11K01L01 334:S96N03 335:T98V01 336:V98M01 337:S46N39T09C01G01H01 338:D98Y01

339:L55I44 340:F98V01 344:F98V01 345:E84D15 346:T95I04 347:V79I 19A01 348:S95T04 349:T95A03G01 350:C80A06T06F04Y01 351:L93I06 352:Y76Q11N06L03F01H01 354:S92V07 355:F85L14 359:I88M06V04 360:H46Y30K12R04N03C01Q01 361:Y98F01 363:E98D01 364:I98V01 366:A66V12T11E04K04 367:K90R07T01 368:I93V06 369:Q88H11 370:E96A01G01 373:D93G04N01 374:G71R15E07A03K01 375:N82V09K06I01 376:I98T01 377:G98A01 378:L74R09M06F03S03Q01V01 379:-88D09N01 380:K76R23 381:P63S25L11 383:R96T03 384:F98L01 385:E96D01K01 386:D98N01 388:K88A07P03 389:I60N22M 11H01L01S01V01 390198F01 391:P98L01 393:T98A01 396:F93V06 397:I96V03 398:N66S22H09T01 400:I57V41L01

401:F98C01 403:H98Y01 404:A57T19S12V11 405:S92T07 407:L58I20V15F04 408:P96A01L01 409:F95L04 411:I95L04 414:C92S07 415:T96A03 417:A68K15V12T03 420:T66I 12S11V09 421:L96F03 422:N96K03 424:Y95-03F01 428:R58K31Q09 429:K73N12D07G06 430:T98I01 431:C92V07 432:T71V25I03 434:I84V11F04 436:M88Q06I03L01 437:Y87W09-03 438:Q92S07 443:E88P09K01 444:T92S07 445:I80L17T01 446:W96F03 447:D77E09P07K04 448:N76D17H03K01T01 450:N46S30D22T01 451:L73V11K06S06A03 452:F95L04 453:R61Q14S11N09I01K01 455:E76D23 456:R98G01 457:F98V01 459:N85D11T03 460:E84K12D01Q01 461:N95K03D01 462:G49R49Q01 463:-90T09 464:E95K03Q01 465:L98M01 466:N98D01 467:K93S06 468:S79T11N07G01 469:L93K03V03 470:V79T14I06 471:E77D22 473:V92F06I01 474:L82M12F04

475:I90L03P03A01T01 478:M90A06L01V01 480:I88K11 481:R93Q04W01 482:K88R11 484:L90I09

485:G95R04 487:D85E14 488:V84L07I06G01 490:R95Q04 491:N88M11 493:I61V20M12L03T01

494:F96C01L01 495:I73L22V03T01 496:F98L01 497:I76L23 498:T85A12V01 499:T66A15M11S04N01 500:V76L12I11 501:L98M01 503:Q95H01K01L01 504:L88C07F03 505:K90T06R01S01 506:L90F09

507:K60N11Q11E09R06S01 508:K85S07N03Q01T01 509:C82S12H01L01R01 510:P95S03R01

511:G42R42K07V03E01M01 512:A77E07V06Q04D01I01 513:E41Q31K25A01 515:D92V04T03

517:T90D07A01 518:P92S07 519:T79V09M04A03K01R01 520:Y96C01F01 523:A42V26T23S06 524:M98T01 525:K76R23 526:P57-41N01 527:K58-41 528:P52-41N06 529:Y49-41F09 530:-90E09 531:-41Q41H15E01 532:L57-41I01 533:-41Q33E07S07K03T03l01P01 534:A44-41V14 535:E44-41T07K04A01 536:-41P36L14R07 537:R57-41H01

(xvi) N72

l:M79-20 2:A66-21G10S01 3:T78-20 4:S65-15G07M05A03 5:L74-15M05R02V01 6:S65-14G09N07R01 7:P52A15-14M04S04L02I01V01 8:D62-14N10E05K05 9:-97T02 10:-97L02 11:-95F04 12:-95G04 13:-95V04 14:-95K04 15:-95G04 16:-95S04 17:D53-14A11S09E04L04G02 18:P56-14H10S05T04A03R02L01 19137W25- 14Q12R08 20:P41Q27-14L10S05 21:P42L33-14E03M02 22:S41N18-14I14T04A03G02 23:P45S16- 14L12A08T01 24177- 14T03R02 25:S81-14P03 26:T41A15-14S13I09V05 27:Q77-12L08 28:Q86-10V03 29:T75S12-10A01 30:T66-10M10A05E03S03I01 31186- 10V03 32189-10 33183- 10V06 34169F12-10S05V02 35182-10F03A02V02 36:S76-10C05V04T01 37:V82-10L06 38189-10 39:A73V10-10C03 40:A76-10T05I04V02 41:V80-07I07L05 42:H92-04F03 43:V56L30A05-04M04 44:G82A05-04V03W02S01 45:Q77KllL05-04 46:W73R10L06-04T02H02 47189-04S03 48190-04Q03 49:R86-04Q04L02W02 50:Q83-05H02R02L02W02 51:R72-11W10Q02C01H01 52:R83-05Q05L04K01 53:R87-06Q05 54:Q64K12R07-06G02L02P02

55:P60L16R07-06Q03K02S01 56:G50W19R15A06-03C02L02 57:S73R08L04-03K02A02F02C01P01

58:A53S21E07R05T05N02-01 59:P97-01L01 64:A49P42Q06 67193V06 71:A92L03V03 72:A87L04S04V02 73:A51Q19S18T05E04 74:V48M28L21 76:P35Q22S18R15K04N02 77:A89Q03T02N01V01 78:P61S22A13 80194V05 81:S76A10Y09L03 82:F95L04 83:A84T07S04G02 84:R95K04 85193M05 86:A96R03

87:R79Q08K05S03G02 88:R80T09K05A02I01 91:D92A05S01 92:V96I03 94:Q94K02T02 95:I86L13

96:R84H10K04 99:S76N13R05T02G01 100:C79W12R08 101:P84R08Q03T02 102:V79I20 106:N97S02 108:E94Y02Q01 109:R71S18E05Q02H01 112:H47R47K03-01 113:Q86E10G02-01 114:A98-01 115198-01 116:V90L05I02-01 117:Q75R13K05H03-01 118:Q96K02-01 119:G91S05A02 120:A69S18E04N02T02V02 121:A69T09I07D06V06 124:D74G22S02 127:P67S13R10D06 129:A74P18Y03T02 132:R75Q21

133:V76L15F06E01 134:V91I08 136:G88N07A02D01 138:R84K05L05H02G01 140169M22V05I01

143:G84S14 144:-97T02 145:H32Q24G10P09K06R06N05T02S01 147:S94G03 148:E88Q06A01D01P01 149:R26H25L16S15A05N04Q01T01 151:K96Q02 152:V39A36L15T04E01 153:Q76H14R07 155:R92K05S01 156:A76V09L05I04S02-01 157:A98-01 158:H64Y15Q10F06-01 159:S72G15A05N03T01 160:T82M07I05A04 161:M63V26L05I02 163:A82N11T03S02 165:S93F02A02 166:T93-04P01 167:R76G 19-02 168:Q67H11S07- 02N02E02G02K02 169:P81L05S04-02A02V02 170:R77A08K03-02G02Q02 171:S66T13G 12A03P02

172:R93K02S02 173:R71Q15G02T02K02H01S01 174:-96C03 175:-96S03 176:-96C03 177:V56L25I 11P02R02 178:L93F02I02 179:E97Q02 180:G73Q13R07E03 181:H95R02P01 182:V70L17A10I02 183:L84V12Q02 184:G59S20A12C05M01Q01 186:A92V05T01 187:R92Q06 188:E84A12F02 190:V93I03L02

191:A66E15R12K03 192:L76V19A02 193:L93M03F02 194:V89L06A04 195:R89E03Q02S02W02

196:G76R15L04K02 197:S86C12 198:A82S12E02K02 199:G77D15K03E02S01 201:A87Q04S02K02T02 202:F82V05Y02C02G02P02-01A01 203:L79V07F06I06 204:D97N02 206:R55T21A12S05G02M01

207:P56Q23R19 208:L56P21S08V05Q03N02 209:T59I18L16V03A01 210:V60I24L08T05 211:V98L01 214:A97C02 217:M94I05 218:S94C05 220:V77L17I02A01 224:C79R12K05H02 227:S73N18D04R01

229:D82G11S04 231:A69P15G05K03E02S02 234:R51L44Q04 235:E69R12G08N03A01S01 236:L96I03 237:L82V13I04 238:S79G 16K02N01 239:H79R16L03 241:E91D07 242:E75Q17K03R02D01 244:G98M01 245:R92K02N02Q02 246:T91A08 247:V96A03 248:G97A02 249:A97S02 255:V83A10F03M01 256:L74M22I03 259:L97M02 260:Q89R07K01 261:R58L21Y16C02H01 264:N88S08R02 266:V90M05L03 268:T82A11S05 269:A65T22V07S03 270:F84Y11L03 271:R92Q05A02 272:E63A13Q11T03D02N02K02

274:E61Q17R13K03M02 275:Q77D05E05T05K02A02R02 276:L90V07I01 277:N98L01 278:R92Q04H02 279:N70D16S04E03R03 280:F96L03 281:S69Y19T05N03 282:N69G 12S09D07 284:V87I 12

285:L72R13F05Q05H01S01 286:D79G 10K03A02E01 288:F94V05 289:L79R07F05V04K03 290:R71Q15K07E03 292:R77C11Q06H02L01 293:E76R10S06G05 294:S89T07R01 295:L91Y04I02F01 296:R66Q10V10D04K04H02 297:P96S02 298:G97R01 299:A86T05V04D02 300:A77G07I05P03T02V01 301:P94-03 304:M92L04V02I01 305:M92T07 307:A97C02 308:F97C01L01 309:I97M02 310:L69R13H07A03I03S02 311:S69L20H04T02I02 312:A71Q13V09I02S02 313:G42E35Q12R05D02 314:K62E15T08A04R04Q02 315:K38E31Q14-10G02 316:A66-17E07K06V01 317:A58-22T10E02S02K01 318:G34E25-22R05A04D02K01P01Q01T01 319:G44D29- 18S02A01E01R01 320:S63-18P08N05A01K01 321:G53-16D15S06E04R01T01 322:D62-19E11G02T01 323:G56-17S14D05V04 324:G66-13P05R05N03S02T02 325:A60P21S07F05H02L02 326:R73G 15A04S02Q02 327:L95Q02T02 328:D79P08Q05S04E02 329:L64V13M07E05D03K02T02A01 330:E87D05-02A02

331:Y39N28H 17D08-02S01 332:V96I03 333:P94V03 334:A82S10G07 335:T92V04S02A01 336:V76I22L01 339:I97L02 343:S95G04 344:Q96F03 347:L94I04 350:A97T02 352:Q80L19 354:L92V04I02 355:L94I02F02 356:I55L30V14 357:L76F16Y03I02 358:F77L22 359:T71I20V05M02 360:R95K04 362:P96S03

363:E46D41K10N01 364:V93I05 366:A85T05K02V02E02 367:R75K19Q04 368:V80M 10L07I01 369:Q97H02 370:A76E23 372:L79I 10V09M01 374:Q74R20K04 375:V89I 10 376:V96I03 379:D89H03N02E01

383:C86S05R04T03 384:M48L30A11F03I03V02 385:D48E23G 15S09A01 387:Q95R03 388:P95A04

389:N58H28K06R05 391:P96H02 393:V82I 12T04 394:M82L10E04V01 396:F97V02 397:L92I06 398Ύ96Η03 400:A57S24T13I03 401:M93F03L02 403:F95H03 404:S97T02 407:V82L16 409:V89F03I03L02 411:I97L02 414:A90S07 416:T91N05A02 417:A64T23D03K03V03 418:N62D23S12 419:T56A43

420:S63F25V05C02T02L01 421:V72I 15L10F01 422:L76M 18N03 425:H66Y19L08F05 429:D74N22G02 432:V69I30 434:V96I03 436:Q97M02 444:V61A25S03Q02E01G01L01T01 445:K96L03 446:W98F01 447:P69S26Q02L01 448:N91D05S01 450:E95D04 451:D76N13A02K02E02 453:D76N20E02

455:A67T14G06S05E03V02 459:D97N01 460:K74E23Q01 461:D76N18K03 463:-96T03 464:F66L16C05S05E03A01I01 465:I85L10F02 466:N87D12 467:K96S02 468:D79E06N06A04T03

469:L96K01M01 470:A61T38 471:S92D03G02N02 472:S71R12N08K04G02 473:V97F02 475:I95L02P01 477:S96G03 478:V75L11M07A03T02 480:K95R04 486:E97D02 488:L94I05 489:S95A04 490:K96R03 491:M85V08T02I02 492:Q75L19E03 493:L89M09 497:I75T15L05F02 498:S91A08 499:I93T03V02 500:L97F02 501:A79V15L04 502:H96Q03 503:Q87E12 505:N84D05K03T02H02S01 506:F97I02 507:K42R38T12I02L02E01 508:A91V05S03 509:N94S05 510:P80Q18 511:N46D42K07E02 512:E96G03 513:P67D20S06E03L02

514:S61P12A10L08-04W02 515:K74N10E05T05V02S01 516:M89L07V02 517:D56S23N18 518:F94S03 519:S48N25T22 523:T95S02A01 524:I92M03L02 527:K97Q02 528:S76P17N02A02 529:F97L01 530:-96E03 531:K66T20R08H03S01 532:I66V22L10 533:N74H20S05 535:T79S18 536:L96P03

(xvii) N98

l:M91-08 2:A75G 11-10S01 3:T90-09 4:S75G08M06A04-03 5:L85M06-02R02V01 6:S75G 10N08-01R01 7:P60A18M05S05L03-01I01V01 8:D72N11E06K05-01 9:-96T03 10:-96L03 11:-95F05 12:-95G05 13:-95V05 14:-95K05 15:-95G05 16:-95S05 17:D61A13S10E05L04G02-01 18:P65H12S06T05A04R02-01L01

19:L43W29Q15R10-01 20:P47Q31L12S05-01 21:P49L39E04M03-01 22:S46N21I 16T05A04G02-01

23:P51S19L14A10-01T01 24:L90T04R03-01 25:S93P04-01 26:T46A18S16I 10V05-01 27:Q89L08-01

28:Q94V04-01 29:T86S09-01A01 30:T75M 11A05E04-01I01 31:L94V04-01 32:L98-01 33:L90V07-01

34:L76F13S05V02-01 35:L89F04A02V02-01 36:S88V05-01C01T01 37:V95-01L01 38:L98-01 39:A80V12C04-01 40:A83T05I05V02-01 41:V90I04L03-01 42:H95F04 43:V65L24A05M05 44:G86A04V04W02S01 45:Q89L05K03 46:W85R10T03 47:L95S04 48:L95Q04 49:R96W02 50:Q89R03L02W02-01 51:R77W11-08C01

52:R90L05Q03K01 53:R96Q01 54:Q71K14R05L02P02 55:P69L19R05K03S01 56:G57W22R09A07L02 57:S85K03A02F02R02C01P01 58:A57S25R06T06N03 59:P96-01L01 64:A55P35Q07 67:L92V07 71:A91L04V04 72:A85L05S05V03 73:A59S21Q08T05E04 74:V55M33L10 76:P40Q25R17S07K05N02 77:A90Q04N01V01 78:P55S25A15 80:L94V05 81:S82Y10L04A02 82:F95L04 83:A87T06S05 84:R95K05 85:L92M06 86:A95R04 87:R84Q10K05 88:R93K06 92:V98I01 94:Q95K02T02 96:R82H12K05 99:S81N15G01 100:C90R07W01 101:P82R10Q04T02 102:V76I23 108:E93Y03Q01 109:R69S21E06H01 112:H55R40K04 113:Q89E10

116:V94L05 117:Q86K06H04R02 118:Q97K02 119:G90S06A03 120:A65S21E04N02T02V02

121:A67I09T08D07V07 124:D86G 10S03 127:P65S15R09D07 129:A85P06Y04T03 132:R87Q10

133:V87F07L02E01 134:V90I 10 136:G86N09A02D01 138:R88K06H02G01 140:L65M25V06I01 143:G85S14 144:-96T03 145:H37Q28P10K07R06N05S01 147:S94G04 148:E87Q07D01P01

149:R30H29S17A05N05L04Q01T01 152:V45A41T05L04E01 153:Q81R09H08 155:R92K05

156:A84I05V04S03L02 158:H63Y17Q09F07 159:S77G15N04T01 160:T82I06M06A04 161:M73V15L05I03 163:A82N 13T04 165:S94F02A01 166:T95-01P01 167:R88G10 168:Q77H13N04E02K02 169:P84L06S05V02 170:R90K04Q03 171:S76G 15T08 172:R92K03S03 173:R69Q17G03T03K02S01 174:-95C04 175:-95S04 176:- 95C04 177:V65L17I 13P02 178:L93F03I03 179:E97Q02 180:G85Q06E04R02 181:H97R02 182:V81A11L04I02 183:L86V09Q03 184:G59S22A09C05M01Q01 186:A91V06T01 187:R95Q05 188:E97F02 190:V95I04 191:A70E18R05K04 192:L72V22A03 193:L92M04F03 194:V90L07A01 195:R92E04Q02 196:G75R16L05K02 197:S85C13 198:A81S12E02K02 199:G74D17K04E02S01 201:A85Q05S03K02T02 202:F80V05Y03C02G02P02- 01A01 203:L80F07I07V04 204:D97N02 206:R64T24A06G02M01 207:P64Q27R08 208:L65P25Q04N02 209:T68I21L04V04A01 210:V55I28L09T06 214:A97C02 217:M94I05 218:S93C05 220:V89L05I03A01 224:C91K06R01 227:S70N21D05 229:D93G03S02 231:A74P18K04E02 234:R55L39Q05

235:E80G 10N04A01S01 237195105 238:S90G04K02N01 239:H90L04R04 241:E90D09

242:E87Q05K03R02D01 244:G98M01 245:R93K03N03 247:V95A04 248:G96A02 249:A96S03

255:V93F04M01 256:L70M25I04 259:L96M03 260:Q90R05K01 261:R54L25Y19H01 264:N95R03

266:V90M05L04 268:T95S04 269:A60T25V09S04 270:F95L04 271:R93Q06 272:E73Q13T04D03N03K02 274:E71Q20K04M02 275:Q85T05K03E02R02 276:L89V08I01 277:N98L01 278:R91Q05H02

279:N81S05D04R04E03 280:F95L04 281:S80Y06T05N04 282:N80D08S08 284:V85I14 285:L83F05Q05H01S01 286:D91K04E01 288:F93V06 289:L79R08F05K04V02 290:R80K08Q05E04 292:R82C13L01Q01 293:E88S05R05 294:S89T09 295:L90Y05I02F01 296:R63Q12V11D05K05 297:P95S02 298:G96R01 299:A86T06V05

300:A76G09I06P02T02V01 301:P95-04 304:M93L02V02I01305:M91T08 307:A97C02 308:F97L01

309:I96M02 310:L80H08A04I04S02 311:S80L07H05I03T02 312:A83V10I03S02 313:G49E41Q04D02 314:K71T09E06R05A04Q02 315:K45E36-11G02Q01 316:A76E08K07-05V01 317:A66T11-10E03S03K01 318:G40E28-10R05A05D02K01P01Q01T01 319:G50D34-06S02A01E01R01 320:S73P10-06N05A01K01 321:G60D17S07E05-04R01T01 322:D71E13-07G02T01 323:G65S15D05-05V05 324:G76P05R05N04S02T02 325:A70P09S08F05H03L02 326:R72G15A05S03Q02 327:L95Q02T02 328:D91S05E02

329:L58V15M08E05D04K03T02A01 330:E85D06-03A03 331:Y45N32D10H05-03S01 332:V95I04 333:P93V04 334:A79S11G08 335:T90V05S02A01 336:V73I25 339:I96L02 343:S95G05 344:Q95F04 347:L94I05

350:A96T03 352:Q77L22 354:L90V05I03 355:L95F02I02 356:I51L31V16 357:L88F05Y04I02 358:F89L10 359:T81I09V05M03 360:R95K05 362:P95S04 363:E50D48 364:V92I05 366:A88T04K03E02 367:R86K08Q05 368:V92L05I01 369:Q96H03 370:A88E11 372:L90I06M01 374:Q85R13 376:V95I04 379:D88H04N02E01 383:C86R05S04T04 384:M56L35F04I04 385:D55G18E12S10A01 387:Q95R04 388:P95A05

389:N68H18K07R05 391:P96H03 393:V85I09T05 394:M80L12E05 396:F96V03 397:L90I07 398Ύ95Η04 400:A65T15S 14104 401:M95F04 403:F95H04 404:S96T03 407:V80L19 409:V88F04I04L03 411:I96L03 414:A91S06 416:T90N05A02 417:A68T20D04K04V01 418:N66D17S15 419:A50T49 420:S68F23V05L01 421:V84I07L06F01 422:L89M05N04 425:H73Y22F04 429:D70N25G03 432:V78I21 436:Q97M02

444:V68A18S04Q03G01L01T01 445:K95L04 446:W98F01 447:P76S18Q02L01 448:N92D06 450:E95D05 451:D74N15A03K03E02 453:D79N20 455:A75G07T06E04S04V02 459:D97N01 460:K85E11Q01

461:D89N08K02 463:-95T04464:F64L16C05S05E04A01I01 465:I88L06F03 466:N85D15 467:K95S03 468:D75E07N07A05T04 469:L95K01M01 470:A69T30 471:S90D04G02N02 472:S70R14N07K05G03 473:V96F03 475:I95L02P01 477:S95G04 478:V84M08A04T02 480:K95R05 488:L93I06 489:S95A05

490:K95R04 491:M90V04T03I02 492:Q72L22E04 493:L88M10 497:I84L06T05F03 498:S92A07 499:I93T04V01 501:A90L05V03 502:H95Q04 503:Q85E15 505:N81D06K04T03H02S01 506:F97I02 507:K49R43T03L02E01 508:A90V05S04 509:N93S05 510:P77Q21 511:D48N41K06E03 512:E95G04 513:P78D07S07E04L02

514:S64A11L10-05P05W02 515:K70N11E06T06V02S01 516:M87L08V02 517:D50S26N21 518:F93S04 519:S55N30T10 523:T95S03A01 524:I92M04L02 527:K97Q02 528:S87P05N03A02 529:F97L01 530:-95E04 531:K76R10T07H04S01 532:I76V18L04 533:N72H22S05 535:T77S21 536:L95P04

(xviii) N127 1:-96M03 2:-95A04 3:-95T04 4:-93M06 5:-90M09 6:-90N06T01W01 7:-90M06l02 8:-90A03D03M01 9:-97T02 10:-97L02 11:-96F03 12:-96G03 13:-96V03 14:-96K03 15:-96G03 16:-96S03 17:-90L07F01 18:-63M27S09 19:- 59A21M08V05L04 20:-59L36A03 21:-57S27G04L03F02M02E02 22:-43Q25M 13S10F02W02 23:- 38S25A14P09Q04L03F02 24:V26-20L19S12T08Y04I04N02 25:P43S30-20I04 26:F45-17Q15I09S04L04P02 27:S61M 13-09L08T03W02I01 28:A82V08T04-03S01 29:T79M09S04-03P03 31:L90V04I03F01 33:L93V05 34:A90V04S03T01 35:S77A09T09L02 36:A79T10V05F02S02 37:I65V24T08A02 38:F95L04 40:L85I 13 41:V92I06M01 42:F77L20 43:W91L06Y02 44:V95M02A01 45:V72L13I06F03A02 46:R81K15T02

47:A69G 11T10S09 48:W56L18S18F04-01 49:R45Q40K07W03S02 50:P75T09Q08S05 51:R69Q21K03W03G01 52:V86L07I04A01 53:P95R03 54:K91Q07 55:G95K03 56:L94R03 58:S88N05R04 61:G81E18 63:W93F03R02 64:G84S10P03 65:W92L04Y02 67:L83F08I04V03 68:L59I39 70:H72N27 71:V71M20L05I02 73:T90Q04E02S01 74:L97V02 75:G96R03 77:N72S18Q03T03H01 80:L88V11 81:A66S18V13T01 83:S59T32A07 84:R70K20Q09 85:L76M23 86:S95R04 87:Q82K11A03R01 88:R63Q20K11L02H01 92:V98I01 93:L86M07F06 94:Q93E04T02 95:I93V06 96:R79H13Q03K02 97:I93L06 99:S71C22T04 100:T92R06 101:P96Q03 103:L70V29 106:S95N03 107:G95R02S02 108:L94Y02M01 109:D85E08N03H01 110:T95A03 111:I92V07 112:R88K10 113:Q96E02 117:R74Q13K12 118:Q97K01 119:G95A03S01 120:D85E11N03 123:K93A05M01 127:D97N02 128:L94F05 130:S92T06 131:F88S11 132:T84S07Q06 133:L86F13 134:I67V32 135:T79S09A06G02N01 136:D77N18E02 138:Q79K15H02Y01 140:M91L07 141:T74S15A09 143:N63S36 144:P87T11 145:D95N04 146:S92Y04C02 148:P91E08 149:V93R03 151:A91K04R02V02 152:A95L04 153:R93H04 154:R98K01 155:R90K06H02 156:L97I02 158:Q95L02M02 159:N77D18S02K01 162:N59K34R04 163:T56S41A01 166:I70V16T09L01M01 167:A92S04G03 168:S93E03K01P01 169:D88S08N03 170:P95K04 171:A63T17S07G06-02N02

173:S70A08T07V06L04 174:S85C11F02Y01 175:S96T03 176:C98-01 177:Y93L04P02 178:L97I02

180:E79D13M06 181:H97R02 182:V95A02I02 183:S83R04I02Q02T02C02N01 184:K90R04Q02A01M01 186:A98V01 187:E83N10Q04K02 188:A66H18V04Y04E02F02C01 190:L40I36V22 191:S65G 18K05T04R01 192:K53R42A02V02 193:L52F47 194:Q89L08M02 195:E76K15Q04D03 196:L72Q20R04A02 197:M92S04T02 198:A80S12E03K02 199:G53E34K07S01 200:P31V31A22G04K04S02T02 201:G95Q03

202:R40H36C11S04A02G02P02 204:D85E13 206:Y76V11T04F03H02S02 207:N50S25R09G07D06

208:Q63H22E05Y04L02 209:V85I 11M02 210:V77L17T04 211:V43L20E13A11G04M02S02R01 212:S95A03T01 214:A89V06C02T01 215:N82K10S03R02G01 218:G90C08 219:A97V02 220:M95I02L01 224:Q64K28H04R02 225:H70N15R12 226:F90Y09 227:P86D09S03 228:Q68E11R10H09 229:S64K11D10R04T03-02H01N01 230:S84D08N07 231:E68K13D11Q04-01 233:M80L12F04K02 234:L90V06F01 235:S79N10P03T02R02 236:L75I22V02 237:V66I24L08 238:K55E14N09R06M05S03T02H02 239:N46S36L08T03G02H02

240:S77T18N04 241:H54N26K06D05S05 242:D49E47I01 244:V89G06M01 245:E93K02N02

246:T55S17N14I05V04 247:A85V14 248:S75T13A04G03I02 249:S91A04N02T02 250:G96A02 251:N89S10 252:P84A11L04 253:V91A04L02 256:F89I09L01 258:I84F06V05W03 259:L94F02M02 260:R59K20Q18H01 262:L79M14F03I02 264:N83S11R02T02 265:P95S03 266:-96V03 267:-97R02 268:-97S02

269:A67T11S08G07P03 270:L96M03 271:Q81K16 272:R79K11A04T03 273:F93Y06 274:K97M02

275:A35S25N15D13Q04T04 276:F91L06I01 277:N98L01 278:Q75D10K07E04N02 279:R63K27N06T03 280:F82L15I02 281:L55V32N06F02R02 282:Q40R34L11S04D03K02W01 283:F95S03 284:L86V09I04 285:Q79R18W01 286:K92N04I02 287:T59I23M13K03 288:V93I06 289:Q88K08R02 290:E94K03 291:H95C03 292:Y95R02H01L01 293:Q79R17K02E01 294:D88T09N02 295:F95Y03 296:D87N10E02 297:K72E20P03R01 298:N75S13G05R03D02 299:S75R08N06H05V03 300:V52I47 301:-97P02 302:Q89R10 304:I95V04

305:T77V12I05A02M01 306:G84D08S06 307:A93S04C02 308:L96F03 309:F69L21I08 310:K90A04E04 311:H97Y02 312:S61N13C09Y06V03R02T02I01 313:E77K13Q09 314:K54D20E13N11

315:G43S20N19K09Y03D02 316:S61K20P15T01 317:R63D10Q06G04K03V02L02T02-01N01S01

318:A65N08D06V05T04S04P02-01 319:S56-13N12G07D04E04 320:-90N06G01 321:-96G03 322:-96E03 323:- 93A03S03 324:G72S11N08A03D03 325:G57D15R08I04N04P04V02S02 326:L62H18Q06A04R02F02

327:I84L08M06 328:P80S16L02 329:Q64H19D08E04R02 330:E87K10-01 331:K93H03N01 332:I81T18 333:V95I04 334:N86S13 335:L75I18T04V02 336:V74I25 337:N93T03L02 339:I75L25 341:G93A06 344:F97L02 345:D95E04 346:T86P11S02 347:V57I42 348:T94S03A02 350:A97T02 351:I89L10 352:S85T09Q04

354:S93V03C02 355:L89I09F01 356:M67L25I06T01 357:Y88L11 359:V96M03 360:T90K05A04

361:N52K28Y07W04R04 363:E72K11N09G02D02R01 364:I81V14K02 366:R76K18E02L02 368:I97V02 369:Q86H13 370:E54K41R02Q01 372:L95I04 374:T77R14A04E01Q01 375:V97M01 376:I81V12T06

379:A59D20E08G06T01V01 381:R51Q38L04K02Y02 383:R93Q03W02 384:L94F04 385:S92E04A03

388:P77L10S09A03 389:Q93N04 392:Y95L03 393:L46M45T07 395:A96S03 396:F93V04S02 398:L95H04 400:T49I32L08V06M02 401:F90Y09 403:H87Y12 404:S65T34 407:V84L13I02 411:I95V02L02 414:S96C03 416:T91I06V02 417:R84K15 418:D96A01N01 420:T77S13V06I02 421:L98F01 422:N81K18 424:F92Y06 425:Y75F14H10 428:K95E02R02 429:E79G09D06K05 430:R70C18T06H02 431:C91V03L02Y02 432:V86I13 434:I63V36436:Q97M02 438:Q86H09S03 439:V96I02 443:P47Q35E14R01 444:K74E11Q06S03T01

445:L63V20Q15 446:W98F01 447:G68E21K06P03 450:S50F44D04 451:E77V09A07K04 453:R90N06Q02 457:F98L01 459:T86D03N03V02S02 460:A71D08S08E05N03T01V01 461:D59N20H06E05K04Y02

462:G74N12D09S02 463:T88S07-01N01 464:A61T24S08E04 465:I91L06V01 466:N79D12S06 467:K95S02R01 468:T65P11I08A04F03N03 469:L83A08E02Q02K01M01 470:S95T04 471:E93D06 473:V79M10I06F02 474:M75L14I09 475:L77I19M02P01 477:G96S03 478:M65L31A02 482:R97K02 487:V65T13I08L04E03S02 488:L70P12M 11105 489:A91G08 490:K76R22 491:W89M05S03 493:V61I34M04 498:A96T03 499:I90T08 502:Q96H03 503:Q64R31H02 504:L93C03I02 505:E95K04 507:S94K02E02 508:V93S03N02L01

509:P91S06L02 510:P75A18D04 511:G95K03 512:V80T05E04L04I01M01Q01 513:K88E06Q01T01

514:V93L06 515:D96V02T01 516:L92M07 517:T96D03 518:P96S03 519:I65T25N04Q02S01 520:Y97F02 525:K98R01 526:H71P27L01 527:A45P24T13K06G04Q02V02 528:R65H12P07I06T04N02S01 529:C95F03 530:E75K13Q06H01 531:H94Q02Y02 532:V70I09L09F08M02 533:Q95S03 534:A88V06-04 535:R76W06K06- 04T03Q02 536:L52P41-04 537:R95-04

(xix) N128

1:-96M03 2:-95A04 3:-95T04 4:-93M06 5:-89M09 6:-89N06W02T01 7:-82M 11106 8:-59M32A03D03 9:-97T02 10:-97L02 11:-96F03 12:-96G03 13:-96V03 14:-96K03 15:-96G03 16:-96S03 17:-59F20L10P04S03M01 18:- 56S42 19:-56V29L04M04A02 20:-39F25M15L08Y07S02 21:-36G34L14R04V03E02M02 22:L38F33-20S06 23:P33S30-20G05L03R03A01 24:I57V09T08L06M06A04-04N02 25:P51S37F09-01 26:I69M18T05V02F02L01 27:S95L03 28:A88V09T02 29:T90S05V02M01 30:E97D01 31:L78F14V04I02 33:L93V05 34:A93S03T02 35:S75A11V04I04L02T01 36:A55T20V18F02S02 37:I59V29T11 38:F96L03 40:L93I06 41:V81G09I05M03 42:F84L15 43:W93L06 44:V95L02A01 45:V70I22F03L03 46:R91K04T02 47:A79T08S07V02-01

48:W47S30T08L06F04-01R01 49:R56Q31K05W02S02 50:P76T09Q07S05 51:R69Q19W06K03

52:V88I04L04A01 53:P95R03 54:K91Q06R01 55:G95K03 56195R03 58:S77N14R04T02 59:P97L02 61:G91E08 63:W93F03R02 64:G87S06P03 65:W90L06Y02 67:L86F05V04I03 68:I54L45 70:H81N18 71:V61M23I07L04A02 73:T89Q04E02M02 75:G98R01 77:N79S12Q03T02 80:L88V10 81:A70S16V12 83:S54T30A14 84:R75K17Q06 85:L73M26 86:S95R04 87:Q84K08A03E02R01 88:R63Q25K09C01H01 92:V97I01 93:L81M 10F07

94:Q90E06T02 95:I93V06 96:R84H09Q03K02 97:I91L07 99:S66C27T04 100:T92R06I01 101:P96Q03 103:L60V39 106:S96N03 108:L93Y02V02 109:D86E07N06 110:T96A03 111:I91V08 112:R84K13 113:Q97E02 117:R84K11Q04 119:G94A04 120:D90E08 123:K93A05M01 127:D95N04 128:L83F16 129Ύ97Η02

130:S90T09 132:T85Q06S04N02 133:L74F25 134:I84V15 135:S58T22A09G03I03M02 136:D54N35E04G04 138:Q88K08E02 140:M95L03 141:T72S22A04 143:N56S38G04 144:P92T06 145:D95N04 146:S93Y04 148:P92E07 149:V91R03L02A01 151:A93K04R02 152:A94L04 153:R95H04 155:R93K06 156:L97I02

159:N90D06S02K01 160:A82G 16 162:K90R04N03 163:S87T09N02 166:I65T18V07L04M03 167:A93G03S03 168:S91E03K01L01P01 169:D91S07 170:P95K04 171:A75T18G04-02 172:S96L02 173:S66A18L05T04M02V01 174:S86C06T04 175:S97T02 176:C98-01 177:Y93L04P02 178:L97I02 180:E93D03K02 181:H97R02 182:V97I02 183:S81K03R03Q02T02C02N02 184:K92Q04A01M01 187:E86Q04K04D02N02

188:Y59V17A13H02E02F02C01 190:I71L20V08 191:S53G25N09K06R02 192:K77R10T08A02V02 193:F70L29 194:Q91L03M02R01 195:E88K10 196:L85Q12 197:M95S04 198:A82S11K02T02 199:G50E31K11R04A01 200:V47P31A04S04K04G03T02 201:G96Q03 202:H72R17S02A02P02C01 204:D81N14E03 206:Y91T04F02C01 207:R90K09 208:Y94Q04 209:V77I 10L10M02 210:V93T04M02 211:V97M02 212:S95A03 214:A86T11C02 217:I95V04 218:C91S07 220:M51I45L01 224:Q50R33K15 225:R97L02 229:D79N17E02 230:D48H27N19S04 231:Q90K04E02 233:L89F10 235:S84N07D06 236:L61I36V02 237:V72I27 238:N81D10G02K02S01

240:S61N36G02 241:N92D07 242:E84N13 244:G95A02M01 245:E85K05D04N02A01

246:V72A08I07G04T03M02 247:A38V31T29 248:A68G30 249:S95A04 251:N75Y14S09 252:P95L04

253:A74V15S02G01I01M01T01 256:I81F14L04 258:I79V15W03 259:L96M02 260:R95Q04 262:L95F04 264:N89S06R02 265:S40P36T16R04A01 266:-96V03 267:-97R02 268:-97S02 269:A57S30T10 270:L88M 11 271:D62N20K06Q03R02S02 272:A37T11L10V10F09I08G06S02N02D01 273:F97Y02 274:K97M02

275:D87E07Q04 276:L93V04I01 277:N97L01 278:K45E26Q13R12 279:K63R36 280:F90L06I02

281:Y74S10N07H03V02 282:S48I21V13N07D04A02T01 284:M63I 12V09T07L06 285:Q90K04H02E01 287:M54L20I 17K03 288:V72I22L04 292:Y93N02R02L01 293:K72R27 294:T95K02 295:F96Y03 296:E92D06 297:K93P03E02 298:G95N04 299:H92V03R02 301:-97P02 304:I96V03 307:S95A02C02 308:L96F03

310:E84K09A04 312:C94V03Y02 313:Q97R01 314:D76E22 315:K80R17D02 316:R45K37Q14S02 317192V02- 01K01 318:D98-01 319:E95D02-01 320:N98-01 321:-96G03 322:-96E03 323:A94S03-01 325:I77V18P04 326:Q91A04K02L02 327:L93V04 328:S97L02 330:E73D10K09Q04R01 331:K92H03Q02 332:I88V10

333:V54I44 334:N69S18T09G02 335:V56I38T04 336:V96I03 337:L59M 15F09S04I04T04N02 339:L95I04 345:D98E01 347:V89I 10 348:T96S03 350:A96T02 351:I87L09M01 352:S95Q04 354:S93V03C02

356:M67L31S01 359:V97M02 360:T86M09K04 361:N59S28Y06R04 363:R50S18N13E08G05D02 364:V74I22M03 366:R47K45E04S02 367:K97R02 368:I95V04 369:Q96H03 370:E93K05 372:L95I04

374:T88A03R03E01Q01 376:I97V02 378:R93S04 379:A51E19S14D09V04 381:R40Q40W12L04P01

383:R90Q09 384:L92F07 385:S87T05E04C02 387:R97K02 388:P64S18L11A03T01 389:Q79H14N04

393:L53M39T06 396:F96V03 398:L93H04M01 400:T79I08V08M02L01 404:S86A09T03 406:F98L01

407:V72L18I06M01 411:I97L02 414:S94C05 416:T94I04V01 417:R86K13 418:D97N01 420:S76N13V06T02 421:L97F01 422:N50S25K15C04G02R02 424:F93Y06 425:Y94F05 429:G93D03E02 430:R80H06T06C04 431:C95V03 432:V93I06 434:V98I01 435:N97S02 436:Q97M02 438:Q95S03 439:I84V13 440:N98D01 442:D98N01 443:Q81P12E02R02 444:K78E15S03T02 446:W98F01 447:G54D15V13E07P03K02S01

448:D81N18 450:S82N08D04F02 451:E72A11V08K06 453:R72L14N06W04Q01 455:E98T01 458:L95I04 459:T83S06N05D02A01 460:P49A16L13T09S06E04 461:D70S16N08G02T01 463:-91T08 464:T76A15E04G02 465:I66V18L15 466:N65D33 467:K95S02R02 468:A60V22T11H02R02 469:L95E02K01 470:S90T07G01 471:E95D04 472:K95Q03R01 473:V94F02M02 474:I81M08T04V02L02 475:L70I26M01P01 478:L68M28A02 482:K81R15N01 484:I97L02 487:T80I06N04E03S02V01 488:I94L04 489:A70G29 491:L54W32M06F04S01 493:V94M04I01 498:A95T03 499:I91T07 500:L95M04 502:Q91H08 503:Q86R13 504:V68L15I09C03M02 505:E95K04 507:S71R09K04N04H03T02E02 508:V84I09S03N02 509:P40S36T18L03 510:P79L08Q08R02 511:G95K03D01 512:V61E14T13M05K01Q01 513:K89E05R02T01 514:V92L06 515:D96V02T01 516:M92L06 517:T95D03 518:P96S03 519:I80T07L05A02Q02V02 523:T95S02 524:M84L09I04V02 526:H91P04Y04 527:A81P08K06T02 528:R70C14H09N02P02 529:C95F03 530:E92K04Q01 531:H98Y01 532:F88L05V05 533:Q96S03 534:V65A18M 15 535:Q54R17H16K06T03 536:M39L31V17P08T02

(xx) N134

1:-94M05 2:-93A06 3:-89M04T04A02 4:-81M 13G04 5:-73M15P07A01K01 6:-73K08N06E04S02Q02A01 7:- 72A16M06E02 8:-72A18D03V03M01 9:-97T02 10:-97L02 11:-96F03 12:-96G03 13:-96V03 14:-96K03 15:- 96G03 16:-96S03 17:-61M25L06A02 18:-61S22W04A04V03L01 19:-61L21Q06P05V02A01 20:-61V18LllA06 21:-63G25E04S03M02 22:-63S36 23:-60Q15P14S06H01 24:-60G27T06S03A01 25:-49l l8A15S08L06 26:V53I32-11L02 27:S83-11L03 28:A72V20-04S01T01 29:T77S14-04A01G01 30:E94-04 31:V75I 13A04-04M01 32:L86-04F02I02M01V01 33:L59l23V12-04 34:A68V19-04S04T02M01 35:A72S14-05L05 36:A79- 06V06T03I02N01 37 :V70A10T06106-05 38:F91-04L04 39:C90-05F01S01 40:L88-05I05 41:V61I 13L13-05T04 42:F77L13-05V01 43:L78M 12-04102 44:L69V18A03I03-02F01 45:I65L18T09-02V02 46:Q74R20T02-01 47:S78R08T06W02-01P01 48:L65F25R07-01 49:R67Q27W02-01K01 50:Q91P04-01 51:H60Q18R08P06K02- 01N01 52:V70I19L04A02-01T01 53:P94R03-02 54:K77E07Q05H02P02-02 55:G93K03-02 56:L94R03-02 57:K79R16-02Q02 58:S54R34N08-01 59:P83L12I04 63:R92F03W02 64:G93P03S02 65:Y75L10F08W04I02 67:I60L20V14M04 68:L75I22V02 70:N91S08 71:V77M09L08A04 73:E93Q06 74:L96V02 75:R77G22

76:K86S07R04G01 77:D77N18Q03 78:P55T43 81:A41V35S15T07 83:T97A02 84:R76Q12K09E01 85:L72M27 86:S91R05G02 87:Q72R20K05 88:K84R09Q03 91:D98E01 93:M94F05 94:E73Q20M02T02G01 95:V71I28 96:R72T06H05K04Q03S03W02A01 97:I95L04 99:T76S18M04A01 100:R93K02Q02 101:P95Q03R01 103:L83V16 106:S95N03G01 108:L95Y02 109:D75E24 110:T96A03 111:I97L01 112:K59R40 113:Q94E02K02 117:K86R13 119:G89A10 120:E93D05 121:D94E04 123:M90A05K01L01 127:D97-01 128:L94F04-01 129Ύ56Η34Ρ06-01 130:S97-01T01 131:F97S01 132:R52Q36H06K03 133:Y43H33F19N03 134:I52V46 135:S41A29T25G03 136:D61N37 138:Q86K06H04E02 140:L93M06 141:A59T38G01S01 143:S97G02 144:P67T22Y03R02H02 145:D90E04N04 146:S86T04Y04C03 148:E95D03 149:V89A03R03M02 151:K79R19 152:A94L04 153:R95H04 155:K96R03 156:L95I04 158:Q98R01 159:N88S11 162:K93R04N01 163:T82S12N04 165:S97A02 166:I66V17T06S04A02L01 167:A70S18T05G03L02 168:P82A09E03S02K01 170:P90K04L03S01 171:T88N09 172:S88A06T02C01 173:S92T04P01 174:S84C13-01 175:T70S23I04 177:L96P02 178:L94I02V02 181:H97R02 182:V93I04 183:S90T04Q02C02 184:K85T04N03Q02A01M01 186:A97V02

187:D57E22S08N04Q04A02 188:Y93H02E02F02 189:L98V01 190:V93I06 191:T77R06K05I03S03A01 192:K95A02V02 193:F81L18 194:L94Q03M02 195:Q87E10R02 196:L82V17 197:M93S04-01

198:E64D20K05S04T02-01R01 199:E84K11-01Q01 200:E61K27G06Q04 201:K81Q11G05 202:S72R22A02P02 203:F95L02I01 204:D91E04N02 205:P72L25I01 206:Y54N29F05T04C02H01 207:R71Q24S02 208:Y95Q04 209:L71V15I06M04 210:V94T04 211:V95I04 212:S95A03 214:A95C02T01 218:C96S02 220:M75I20L02 224:K93N04R01 226Ύ97Η02 227:D78E13S07 229:N59D29E09S02 230:D96N03 231:Q93K04E01 233:L95F04 235:S58N31R04D03K01 236:I49V25L25 237:V92I05 238:N90D03K02H01 239:L50V28S06E04M04A01 240:N36S30T17G09V04 241:N40E37D14H03T03 242:E71Q20D04K02 244:G64V13T09E02I02N02A01M01S01 245:D59E23N11K02 246:V90T04A04 247:A86T09V03 248:A84G 15 249:S65A27G02V02 251:N86H08S04 252:P89L09 253:A85V09S02T02 258:V62L27I04W03M01 259:L97M02 260:Q70R29 262:L95F04

264:S83N13R02 265:R87P06Q02H01S01 266:-96V03 267:-97R02 268:-97S02 269:T56A20S18N04

270:M93L06 271:K27Q25E11S10D08N07T04A03 272:L67K11A06T04I03M02V02S01 274:K79I09M06L04 275:D79E12Q05A01 276:F49I36L07V06 277:N97L01 278:R40K38Q06T06A02Y02 279:R90Y04K02S01 280:F90L07 281:N36L33S13I05M04V02T02D01G01 282:H22S20A13F11R08L06D05K03I02 283:F85L12Y02 284:L48V43I06 285:Q95E02 286:K84D07T02N02R02 287:I78M07R04A03K03N02 288:V97I02 289:K52Q42E03 290:E93N03D02 292:Y95R02L01 293:E43T33R06S06A02K02D01I01 294:T51S47 295:F66Y33 296:D84E10N03 297:K88E06P03 298:E39N38D15G05 299:H50N43V03S02Y01 300:I98V01 301:-97P02 304:I88V11

307:S95A02C02 308:L96F03 310:E79G 11A04Q02D01 311:H47Q47E02 312:C81S12V03A02 313:Q61L28M03- 02V02 314:E82D12-02K02 315:K82N10E01R01S01 316:K61S31N02-01T01 317:V65A10T06-05L03M03I02K01 318:G43E42D06-04 319:E43A36T06-05D03G02 320:N50D36-05S02T01 321:-96G03 322:-96E03

323:A48T29S07V05-03G02 324:A33N21H20R15-02C01S01V01 325:V35T25I22M04P04A03L02

326:Q68P24A04L01 327:L55I38P04V01 328:S50P48 329:K43N37D14S02 330:E87G08K02Q01

331:K88S04H03Q01 332:I97V01 333:V52I45M01 334:N72S16H07G02 335:L52I43T04 337:N90Y04T03S01 339:L88I11 343:G97A02 346:T97S02 347:V92I07 348:T79A15S04 350:A83G 10T04S02 352:S95Q04

354:S89C05V03G01 355:L95I03 356:M90L06I01 358160V29A09 359:V55A39M02S01 360:T50L40K04S04 361Ύ91Η04Ν02 363:D63N18E08H06K01 364:I93M02V02 366:K95R02E02 367:K79R20 368:I97V02

369:Q93H06 370:E86A06K03D02Q01 372193106 374:Q81R13E03 375:T85V06I03N02R01 376:I98V01 378:R54Q40W03 379:E95D04 381:R92L04K02 384:L95F04 385:S93E04A02 388:G72P15S06A04

389:T56M27N04L03S02K01Q01 390:L98M01 392Ύ97Η01 393:T95M02 396:F97V02 398:L95H04

400:M86V06I04T01 404:S97T01 406:F93L04Y01 407:L84V10M04 410:T97A02 411:I95L04 414:S76C21-01 417:K66R31 418:D63A36 420:V81A13I02S01 421:L98F01 422:N98K01 424:Y97F02 425:Y89F09H01

426:I97V02 429:D90G06N02 430:T46R36L15 431:C96V03 434:V52I47 436:Q97M02 438:Q96S03 439:V97A02 443:E91P06K01 444:K85T06S04N02 445:L94I05 446:W98F01 447:K93P03E02 448:D88E11

450:S59L23E06Q04D04 451:T60A25S08K03R02 453:N81D06K05R04 455:E96K01

459:N65S20T03D02R02C02H01 460:A86P06E04D01T01 461:A31E24D22G08T06N04S01 463:T94K02-01A01 464:E86K06R02T02 465:V50I36L13 466:N75S21D02 467:K53R43S02 468:T49V25A12E06D02M02

469:E54D38L02N02K01 470:G43S42A10T04 471:E61D38 473:V91I05F02 474:L57M38V03

475:V34T20A19I 13S06L03P01 478:L93A02M02 480:K95R04 482:R76K23 484:I88L11

487:S39T22P18N08A04E03 488:I95L04 489:A52G47 490:R95K04 491:W90M05G01 492:E68Q31

493:V75I20M04 498:T35S33A29V02 499:T95I04 500:L76M20I03 503:Q93R02E02 504:L95C03

505:E88H04K04Q01 506:F96I02 507:S91K02N02E02 508:V47L40I05S03N02 509:C38R35S16A04Q01 510:P46D42E04N04G01 511:G95K03-01 512:E47K30Q10V02G02S02-01A01T01 513:K50E33R05Q04P03 514:V90L05A03 515:D95V02T01 516:M53I37L06V02 517:T95D03 518:P95S03 519:Q47L34I06T04H03R01V01 523:T63S31V02L01 524:M70L28 526:H53Y40P04 527:K97T02 528:R55K34Q04N03P01 529:C95F03Y01 530:E95D02K01 531:H58C29A04S04 532:F93L06 533:Q95S03 534:V54I36A04M03 535:K84R09T03Q02 536:Q50K34P09L02R02

(xxii) N207

1:-68M31 2:-68A31 3:-63T36 4:-57M42 5:-52M42L05 6:-47N47S05 7:-47M31l lOS10 8:D52-47 9:-78T21 10:- 78L21 11:-68F31 12:-68G31 13:-68V31 14:-68K31 15:-68G31 16:-68S31 17:-47L26G 15E10 18:-47S31T21 19:- 47L36W15 20:-47L26Q21P05 21:-47E26M21P05 22:-47A26S26 23:S52-47 24:-47T26R21L05 25:-47S31P21 26:-47l26S26 27:L63-36 28:Q52V26-21 29:S78-21 30:A31E26-21S21 31:L52V26-21 32:L78-21 33:V47L31-21 34:S36-21F21L21 35:L63-21A15 36:C36V31-21T10 37:V52L26-21 38:L78-21 39:A31C26-21V15I05 40:A52I26- 21 41:I47L21-15V15 42:H57F26-15 43:L84-15 44:G36V26-15W15C05 45:K52L31-15 46:L31W26T21-15R05 47:L47S26-15A05V05 48:L57Q21-15V05 49:R47Q21-15W15 50:Q52-15H15W15 51:R63-15Q15H05 52:R42L31-15K10 53:R63-21Q15 54:R42-21K21G 15 55:R36-21K21Q21 56:R84-15 57:R42K21-15L10S10 58:R31A26E21N21 67:L63V36 71:A73L26 72:A68L26M05 76:S57K26N10Q05 77:A68Q26L05 81:S84A15 82:F73L26 83:A52T26S21 84:R68K31 85:L57M42 86:A73R26 87:R36K31S26G05 88:T47K42R10 91:D68A31 94:Q84T15 95:I52L47 96:R52K31H15 99:S68R31 100:W52R47 101:P52Q26T15D05 108:E68Y21-05D05 109:R57E42 111:I94M05 112:R63K26-10 113:Q68E21-10 114:A89-10 115:L89-10 116:V89-10 117:R47K42-10 118:Q73K15-10 119:G84A15 120:A73E26 121:A52D47 127:P52D47 129:P52Y26T15S05 133:L52F47 134:V73I26 136:G73N26 138:K42L31R26 140:L57M42 143:G73S26 144:-78T21 145:G52N36S10 147:S73G26 148:E89D10 149:R52L47 152:L68V26F05 153:H78Q21 154:R94W05 155:R57K36S05 156:I31A21V21L15-10 157:A89-10 158:H47Q42-10 159:S42A31N26 160:T73A26 161:V68L31 163:A73T26 165:S94F05 166:T94-05 167:G94-05 168:S42N26E 15K10-05 169:P63S31-05 170:A42K26Q21-05R05 172:R52K21S21-05

173:R57T21K15-05 174:-73C26 175:-73S26 176:-73C26 177:L57V21P15M05 178:L63I21F15 180:Q42R31E26 181:H84R15 182:L47V36I 15 183:V42L31Q21C05 184:G57A15M 10Q10S05 186:A89V10 187:R68Q31 188:A47E36F15 190:V73I21M05 191:R42A31K26 192:L68A15V15 193:L78F21 194:V52L47 195:R68E26S05 196:G52L31K15 198:A57S26K15 199:G57K26E15 201:A52Q31K15 202:F52Y21P15A10 203:L52F47

206:A42T31S26 208:V31Q26S21N15E05 209:L73I26 210:V57T36L05 214:A84C15 217:M68I31 218:S68C31 220:L78I21 224:R57K42 227:S73D26 228:H94-05 229:D52G42-05 231:A42G31K26 234:L68Q21R10 235:R47N26A10S10G05 236:L73I26 237:V47I26L26 238:G73K15N10 239:R73L26 241:E52D47 242:Q73E26 244:G89M10 245:R57K21N21 246:T63A36 247:V73A26 253:V94L05 255:A47F26V26 256:L52I26M21 259:L78M21 260:Q73R26 261:R57Y42 264:S42N36R21 266:V94I05 267:R94-05 268:A47S26T21-05

269:A52S26V21 270:Y42F31L26 271:R57Q42 272:A47T26N21D05 274:R47K26M15Q10 275:Q63D31E05 277:N89L10 278:R73Q26 279:D52R26E21 280:F73L26 281Ύ73Ν26 282:G52D47 284:V57I42 285:R52Q36H10 286:G47D26K26 288:F57V42 289:L63K26V10 290:Q73E26 292:R57Q31L10 293:R63S26G10 294:S52T47 295:L52Y31I15 296:R52D31K15 299:A57V31T10 300:A52I42T05 301:P73-26 304:M73V15I10 305:M63T36 307:A84C15 310:R47A26S15H10 311:L47H31I21 312:Q47V31I21 313:Q42R31D10G10E05 314:E84Q15 315:Q47K26G15E10 316:-52K47 317:-63T21K10A05 318:-63D15G15E05 319:-68D15S15 320:-68N31 321:- 52G47 322:-63E31D05 323:-57S42 324:-52N26G21 325:P78H21 326:R47A26S21W05 328:Q31S31D21P15 329:L52D26K21 331:H73Y26 332:V73I26 333:P68V26E05 334:A52S47 339:I84L15 343:S68G31 344:Q73F26 347:L68I31 350:A78T21 354:L52V26I21 355:L84I15 356:I52L47 357:F63Y26L10 359:I52V26M21 360:R68K31 363:E47K36D10N05 364:V63I36 366:A63K21E15 368:M42L31V15I10 369:Q78H21 372:I47V42M10 375:V57I42 376:V73I26 383:C57R26S15 384:A31F26I21V15M05 387:Q68R26K05 388:P68A31 389:H73N26 393:V42I31T26 394:M68E31 396:F78V21 397:L63I36 398Ύ73Η26 400:S68I26T05 401:M73F26 403:F73H26 409:V73F26 411:I84L15 414:A57S42 417:T52K26A21 418:D68N31 420:S36F31V31 421:I73L15F10

422:M68N26D05 425:L42H31F26 429:D78G21 432:V52I47 436:Q84M15 444:A42S26Q21V10 445:K73L26 446:W89F10447:P57S42 448:N63D36 450:E68D31 451:D57A21K21 453:D57N42 455:T42E26S21A10 459:D89N10 463:-73T26 464:F47E26A10L10S05 465:I63L36 467:K78S21 468:D73T26 469:L89K10

471:S73D26 472:S73K26 473:V78F21 475:I78L10P10 477:S73G26 478:L42V36A21 489:S73A26 490:K73R26 491:M73V26492:Q73E26 493:L68M26I05 497:T63L26I10 498:S68A31 499:I73T26 501:V68L31 502:H73Q26 505:N52K26T21 507:T68K21E10 508:A73S26 509:N73S26 511:N68K31 513:D73E26 514:L47P36S15 515:K52T31V15 516:M52L47 518:F63S26C05Y05 524:I63M26L10 528:P78N21 530:-73E26 531:T73H26 532:L57I26V15 533:N68S31 536:L73P26

(xxiii) N223

1:-92M07 2:-90A09 3:-82T09M07 4:-70M23G04L01 5:-62M25P09K03 6:-62N14E07K07S04A01G01 7:- 60A18M15E04 8:-60A23D07V06M01 9:-93T06 10:-93L06 11:-92F07 12:-92G07 13:-92V07 14:-92K07 15:- 92G07 16:-92S07 17:-57M 18L15A04S01V01 18:-57S26V07W04L03 19:-57L21Q07P06V04A01 20:- 57V17L15A09 21:-57G28E06M06S01 22:-57S42 23:-54P15S14Q12H03 24:-54G28T15A01 25:- 48A15S14I 12L07V01 26:V43l32-23 27:S68-21L07W01 28:A71V20-06S01 29:T71S20-06G01 30:E93-06 31:V73I12-06A06M01 32:L82-06F04I01M01P01V01 33:L56V20I15-06R01 34:A57V21S07-06T03K01M01 35:A76S09-06L06K01 36:A76V10-09N01T01 37:V78T07A06-03I03S01 38:F89L07-03 39:C89-06F03S01 40:L79I12-06E01 41:V64l l7L12-06 42:F78L14-06C01 43:L85-06M06R01 44:L70V20A04-03R01 45:I60L23T09- 03M01V01 46:Q75R15T06-03 47:S78R09T07-03W01 48:L67F20R09-03 49:R67Q23W04-03K01 50:Q90P06-03 51:H64Q12R09K04P04-03N01 52:V70I14L09-03A01T01 53:P87R07-04 54:K81E07-04Q04R01 55:G87K07-04 56:L87R07-04 57:K76R17-04Q01 58:S54R29N10-03T01 59:P93L06 63:R89F07H01W01 64:G87P07S04 65:Y71L10W09F06I01 67:I67V17L09M06 68:L78I20V01 70:N89S10 71:V71L10M10A06 72:L98R01 73:E89Q10 75:R79G20 76:K95R03G01 77:D79N10Q07H01 78:P51T46M01 81:A57V21S20 83:T96A03 84:R79K17E01Q01 85:L73M26 86:S85R09G04 87:Q70R18K10 88:K87R09Q03 91:D98E01 93:M87F12 94:E78Q17T04 95:V73I26 96:R70K07T07H04Q04S04 97:I90L09 99:T75S18M04A01 100:R96Q03 101:P90Q07R01 103:L75V25

106:S90N07G01 108:L90Y06-01W01 109:D68E31 110:T92A07 112:K59R40 113:Q89E06K04 115:L98P01 117:K87R12 119:G87A12 120:E90D09 121:D96E03 123:M85A12K01 125:R98G01 127:D96-03 128:L87F09-03 129:Y78H17-03Q01 130:S95-03T01 131:F95S03H01 132:R78Q18H01S01 133:H53F29Y15N01 134:V64I35 135:T45A34S12G06V01 136:D87N12 138:Q89K10 140:L85M14 141:T57A40S01 144:P68T26-01H01L01 145:D90N09 146:S79Y10T09 149:V85R07M04S01 150:W98M01 151:K89R10 152:A90L09 153:R90H09 155:K95R04 156:L95I04 159:N89S10 160:A98V01 162:K87R10N01 163:T79S10N09 166:I71T15V06A03F01S01 167:A76S12G07T03 168:P76A09E07K03L01S01 170:P82K10L04S01 171:T98-01 172:S89A07-01C01

173:S89T09-01 174:S79C18Y01 175:T64S29I04P01 176:C98P01 177:L93P04A01 178:L93I06 181:H95R04 182:V92I07 183:S81T07Q06C04 184:K84N06A03M03Q03 186:A98S01 187:D57E20Q09S09G01N01

188:Y90E04F04 189:L96V03 190:V98I01 191:T82K12A01I01S01 192:K90A04V04 193:F84L15 194:L92M04Q03 195:Q79E17R03 196:L85V14 197:M85S09-03T01 198:E62D15K09S09-03 199:E76K20-03 200:E62K23G 12Q01 201:K78Q15G06 202:S81R09A04P04 204:D92E07 205:P98L01 206:Y82T09H03C01F01N01 207:R96K01Q01 208:Y90Q09 209:L70I 12V09M06T01 210:V90T09 211:V98I01 212:S90A07T01 214:A92C04T03 216:V98I01 220:M67I29L03 224:K96R03 227:D87E10N01 228:H98-01 229:N59D28E09-01S01 230:D96N03

231:Q89K09E01 233:L90F09 235:N59S29D04R04K01 236:I65L21V12 237:V90I09 238:N93K04A01

239:V45L31S14E07T01 240:S54N17T15V09A01P01 241:E54D29N09H04Q01 242:E48Q43K04A01D01 243:F98L01 244:G34V26T20N04A03E03M03S03D01 245:D51N25E17K04I01 246:V87T09A03

247:A85T07V04G01 248:A90G09 249:S51A42V06 251:N90S07Y01 252:P87L12 253:A87V09T03

258:V59L23I09W07 259:L93M06 260:Q73R26 262:L92F07 264:S93R06 265:R84P14C01 266:-92V07 267:- 93R06 268:-93S06 269:T32A29S29N07 270:M90L09 271:K29S23N17D12T09Q07 272:L76A07T07I06S01 274:K70I 15L09M04 275:D85Q09A01E01H01 276:F79L15I03Y01 277:N96L03 278:K73Q15R10 279:R85Y10S03 280:F84L14M01 281:L53N21I09M09V06 282:H48S25D12K07G01N01Q01R01 283:F92L07 284:L75V14I09Q01 285:Q98K01 286:K87T06R04A01 287:I70R10A07K07M01N01 288:V96I01L01 289:K85E06Q06D01

290:E98D01 292:Y92R04L03 293:E64R15T07K06D03A01Q01 294:T95S04 295:Y75F25 297:K76E15P07 298:N85G07D04H01 299:N73H14V07Y03S01 300:I96V03 301:-95P04 304:I81V18 307:S90A04C04

308:L92F07 310:E85A09Q03D01 311:Q78H21 312:C92V07 313:L62Q21M07V06T01 314:E75D23K01 315:K95E03R01 316:K95N04 317:V59-09A07L07M07K03T03I01 318:E67D15G09-06A01 319:A53E14T14- 06D06G04V01 320:N85-06S06T01 321:-92G07 322:-92E07 323:T59A18S14G04-01F01 324:A73N21V03T01 325:T54I 14M 10P09A06L03K01 326:Q89A09E01 327:I76L21V01 328:P78S21 329:K71D18N07R01 330:E98K01 331:K89H07N01Q01 332:I95V03T01 333:V90I09 334:N89S10 335:L82T09I07 337:N92T07 339:L84I15 343:G95A04 345:D98N01 346:T98S01 347:V85I 14 348:T90S07A01 349:T98N01 350:A73G20T06 352:S90Q09 354:S92V07 356:M85L12I01 359Λ/93Μ06 360:T87K10I01 361:Y84H09N04D01 363:D39N39E09H07K03S01 364:I93M04V01 366:K93E04R01 367:K75R25 368:I95V04 369:Q89H10 370:E85A07K03D01Q01 372187112 374:Q75R18E03H01K01 375:T79V14I04R01 378:R54Q43W01 379:E90D09 381:R90L09 384:L90F09

385:S90E09 387:R98Q01 388:G76P12A07S03 389:T64M18N 10Q03S03 392:Y98R01 393:T98M01 396:F93V06 398:L90H09 400:M87I09V03 404:S96C01T01 406:F98Y01 407:L78V12M07I01 408:P98T01 409:F98L01 410:T93A04L01 411:I92L07 414:S82C14-03 417:R60K35Q01T01 420:V98A01 421:L96F03 422:N98K01 424:Y98F01 425:Y81F17H01 426:I93V06 429:D90G09 430:R78T15L04C01 431:C92V07 434:V76I23

436:Q95M04 438:Q92S07 439:V96A01T01 443:E84P15 444:K89S07R01T01 446:W96F03 447:K92P07 450:L50E14S14Q10D09M01 451:T68A21K06S03 453:N96D01R01 455:E98G01 459:N64S28D06T01

460:A87E09D03 461:E50D37N09G03 462:G98R01 464:E75K10R04T04G01M01Q01 465:V76L15I07

466:N96D01K01 467:K84R09S06 468:V54A15E14T12L01S01 469:D71E18L06K03 470:G60A17S12T09 471:E92D07 472:K98Q01 473:V93F06474:L62M32V03Q01 475:V54I14T14A06L04P03M01S01 477:G98S01 478:L89A06M03V01 480:K95R04 482:R57K42 484:I96L01P01 487:P40N17S15T14E07A01D01H01

488:I90L07F01 489:A87G 12 490:R90K09 491:W81M12G03C01S01 492:Q68E31 493:V76I14M09

498:S67A14T14V04 499:T96I03 503:Q95R03K01 504:L92C07 505:E90K09 507:S89K06E04 508:V79I07S07N04 509:C70S15R12Q01 510:D64P15E09N07G01K01 511:G92K07 512:K60E20G04Q04S04T03R01 513:K79E12R07 514:V79L12A07 515:D92V04T03 516:M90L09 517:T89D07A01K01 518:P90S07Q01

519:L59I14Q12T09A01R01V01 520:Y98F01 521:G98A01 523:S62T32A01F01L01 524:L64M34V01

526:H89P09N01 528:R89N06P03K01 529:C90F07Y01 532:F87L12 533:Q92S07 534:V89A09T01

535:K81R10T07 536:Q68P15K07L06A01

(xxiv) N224

1:-88M11 2:-87A12 3:-86T08A04M01 4:-75M20G04 5:-68M23P05A02 6:-68N12K09Q04E02A01S01 7:- 66A18M13G01 8:-66A23D06M01V01 9:-94T05 10:-94L05 11:-93F06 12:-93G06 13:-93V06 14:-93K06 15:- 93G06 16:-93S06 17:-58M25L13A01E01 18:-58S25A08W05E01R01 19:-58L23Q06P05V04A01 20:- 58V23L13A02S01 21:-61G20E05M05S05A01 22:-61S38 23:-58P15S13Q12 24:-58G25T13A01S01 25:- 44A16I16S13L06T01 26:V65I26-04L04 27:S88L06-02M01 28:A76V18-02S01T01 29:T75S19-02G01P01 30:E95- 02V01 31:V83I09-02A01L01M01 32:L93-02F01M01V01 33:L68V18111-02 34:A68V19S08-02M01 35:A79S08- 05L05G01 36:A77V11-05T04N01 37:V63A15-08T06I05 38:F86L08-05 39:C93-05S01 40:L83111-05

41:V66ll5L12-05 42:F80L12-05P01 43:L90M05-02A01 44:L75V18-02F02A01 45:I62L22T09-02V02

46:Q80R13T05 47:S76R08T06W04P02C01 48:L80F12R06 49:R65Q29W04K01 50:Q95P02R01

51:H62R15P09Q05K04A01N01 52:V76I11L08A02T01 53:P91R06-01 54:K81E08Q05-01A01S01 55:G90K06- 01E01 56:L91R06-01 57:K77R18Q02-01 58:S58R27N12P01 59:P94L05 63:R93F06 64:G88P06S04

65:Y66F11L11W08I02 67:I63V20L11M04 68:L79I18V02 70:N93S06 71:V86L09A02M01 73:E90Q09

75:R81G18 76:K97G01R01 77:D81N09Q06H01 78:P55T44 81:V50A31S18 83:T98A01 84:R81K13Q02E01 85:L77M22 86:S90R08G01 87:Q69R20K09 88:K83R11Q04L01 91:D98E01 93:M88F11 94:E76Q15T04G02R01 95:V75I25 96:R72K06T06H04Q04A02S02 97:I90L08V01 99:T73S23M02 100:R97Q01W01 101:P91Q06R01 103:L79V20 106:S91N06G01 108:L93Y05-01 109:D70E27H01 110:T93A06 111:I97L01V01 112:K61R38 113:Q94E05 117:K87R12 119:G87A12 120:E91D06Q01 121:D95E04 123:M84A11I01K01L01 127:D97G01K01 128:L91F08 129:H52Y33P12F01 131:F98W01 132:Q68R22K06H01L01 133:Y69F25H05 134:I75V23F01 135:S80A08G05T05 136:N72D25S01Y01 138:Q79K12H08 140:L87M12 141:A79T18G01S01 143:S97G01N01 144:P72T18Y06-01H01 145:D81E09N08 146:S81Y09C06V01 148:E93D06 149:V83A06R06M01S01

151:K87R12 152:A91L08 153:R90H08L01 155:K94R05 156:L95I04 158:Q97R02 159:N87S12 162:K88R09N01 163:T84S13A01 166:I70V12T11L02S02 167:A70S13T08G06 168:P76A09E06K02S02V01 169:S98T01 170:P87K09L01S01 171:T94N02-01R01 172:S88A06-01C01V01 173:S88T08-01P01 174:S77C18-02Y01 175:T63S31I02C01 177:L95P04 178:L94I05 181:H95R04 182:V93I05T01 183:S88Q05C04T01

184:K81Q05T05A02M02N01 187:D43E31Q08S06N05A04 188:Y91E04F04 190:V98I01 191:T80K11S05A01I01 192:K91A04V04 193:F87L12 194:L93M04Q02 195:Q83E15R01 196:L88V11 197:M91S08 198:E55D26K09S08 199:E79K16Q02D01 200:E66K20G09Q02 201:K76Q16G05R01 202:S72R16A04P04G01T01 203:F95I02L01 204:D93N05E01 205:L48P48I02 206:N56Y29T09C01F01K01 207:R51Q41S05N01 208:Y91Q08 209:L77I11V11 210:V88T08I01M01 212:S91A06T01 214:A95C04 218:C98W01 220:M75I20L02T01 221:C98F01 223:G98A01 224:K98Q01 225:R98H01 226Ύ98Η01 227:D83E16 228:H98-01 229:N58D29E08S02-01 230:D97N02 231:Q91K08 233:L91F08 235:S75N20D01H01K01 236:V40L37I22 237:V88I08L01M01

238:N87K04D02G01H01S01T01 239:L87M08D01F01I01 240:N66G 19S13 241:N80D11T06H01 242:E94D05 244:G97M02 245:D61E26N05K04M01S01 246:V87T06A05 247:A93T04P01V01 248:A72G27 249:S69A25G05 251:N76H16S06 252:P91L08 253:A84V06S05T02 258:V48L33I08W06M02 259:L94M05 260:Q55R44 262:L93F06 264:S86N08R05 265:R84P12H02 266:-93V06 267:-94R05 268:-94S05 269:T76A12S09N01 270:M91L08 271:Q50E23K12A06D04H01R01 272:L65A12I08T08V04S01 274:K95M04 275:D91Q08

276:I70L13V12F02 277:N97L02 278:R69K12Q08A05T02G01 280:F88L11 281:N68S26D02G02

282:A26F23S20L13D06I04C01M01N01 283:F97L02 284:V86I 13 285:Q93E05H01 286:K97N02 287:I91K06N01 288:V98I01 289:Q77K19E01R01 290:E90N06D02 292:Y91R04L02F01 293:T66S13R12A04I02 294:S70T27G01 295:F93Y06 296:D97N02 297:K91P06R01 298:E77G09N08D04 299:H93V06 301:-95P04 304:I88V11 305:T98M01 307:S91A04C04 308:L93F06 310:E65G23A08D01Q01 311:H95N01Q01R01 312:C93V06 314:E87D11K01 315:K84N08S02R01T01Y01 316:S63K29T02G01N01Q01 317:V68T11A09I04-02K02G01 318:G76D13E04-02R01V01 319:E86D06-02A01G01K01 320:D73N18-02E01G01T01V01 321:-93G06 322:- 93E06 323:A72S09V08T05-01G01P01 324:H41R31N20C02Q01S01 325:V69I 18P08L02A01

326:P47Q40A08L02S01 327:L83P09I05V01 329:N66D29K02S01 330:E94K02G01Q01 331:K79S09H06Q02M01 333:I77V19M02 334:N44S33H 15G04A01T01 335:I83T09L06 337:N80Y08T06S02G01 339:L95I04 347:V86I 13 348:T59A30S09 349:T98S01 350:A91T06G01 351:L98I01 352:S90Q08T01 354:S80C09V06G02

355:L91I05M01V01 356:M86L11A01I01 358:V59L20A18S01 359:A77V13M05S02 360:L79T11K08S01 363:D80E09H06N02 364:I94V02M01T01 366:K91E04R04 367:K84R15 368:I95V04 369:Q91H08

370:E86A06D02K02Q01 372:L90I09 373:D98G01 374:Q79R16E04 375:T81V12I02A01R01 376:I98V01 378:R51Q40W05C01G01 379:E91D08 381:R90L08K01 384:L91F08 385:S91E08 388:G76P11A06S05

389:T55M22N08S04K02Q02A01I01R01 392Ύ97Η02 393:T94M04L01 396:F94V05 398:L91H08

400:M81I08V05T02A01 406:F91L06I01 407:L84V15 411:I93L05V01 414:S84C13R01 417:K97R02 418:A72D27 420:V72A26T01 421:L97F02 422:N98K01 424:Y98F01 425:Y86F12H01 429:D84G 11N04 430:T93L04R02 431:C93V06 434:I66V33 435:N98S01 436:Q95M04 438:Q93S06 439:V97A02 440:N98H01 443:E83P13K02 444:K75T11S08N04A01 445193106 446:W97F02 447:K90P06E01Q01 448:D93E06 450:S90D08L01

451:T47A38S08K05 453:N79K11R08S01 455:E95K02Q01 459:N79S09D05T04G01 460:A76P12E08T02 461:A62D13T12N08S02 463:T95A02-01 464:E93T04K02 465:I70L20V08 466:N55S43D01 467:R84K09S05 468:T83A09M04I01P01 469:E91L05K02 470:S75G 12T08A04 471:D75E25 473:V94F05 474:M63L31V04 475:A31T25I 19S12V05L02P02 478:L90A05M02V01 480:K95R04 484:I88L11 487:S66T16E06A05D01F01P01 488:I93L06 489:G83A16 491:W88M 11 493:V69I22M08 498:A52T41S05 499:T94I05 500:L52M40I06 503:Q97H01R01 504:L93C06 505:E77H09K08Q01R01T01 506:F93I05V01 507:S88K05E04N01

508:L79V08S06N04F01 509:R59S15C11A09L01Q01V01 510:P93D05G01 511:G91K06-01 512:E83Q09A02- 01K01V01 513:E61K16Q09P06R02A01H01 514:V88L11 515:D93V04T02 516:I72L11M 11V04A01 517:T93D06 518:P93S06 519:Q88T08H02 522:L98F01 526Ύ80Η 11Ρ08 528:K65R15Q08N06P02S01 529:C90F06Y02 530:E91D05K02 531:C58H 19A09S09L01R01 532:F88L11 533:Q91S06A01 534:I70V18M06A04

535:K80R06T06Q05 536:K59Q19P16R04

Table 2. Variable residues Xi - X_n, and amino acid variation at each residue, of engineered ancestral CYP2 sequences corresponding to nodes (i) - (xxxi). For each of the ancestral sequences corresponding to nodes (i) - (xxxi), variable residues Xi - X_n are given in sequential order. For example, for (iii) CYP2_N13_gen, 444 variable residues are given, which correspond to Xi - X444. For each variable residue, the format of the data is as follows: [amino acid position] : [first amino acid variant] [percent frequency of first amino acid variant] ... [last amino acid variant] [percent frequency of last amino acid variant]. Position is given relative to the corresponding AO CYP2 sequence, as described herein. Frequency is relative to all sequences used to construct the AO CYP2 sequence. Note that '-' represents a 'gapVamino acid deletion. For example, Xn of (iii) is given as 14:V29L23A21F15I04T02-01, which sets forth that:

the amino acid position of the variant relative to the alignment to produce node CYP2 N13 A0 is ' 14';

the first amino acid variant is a 'V;

the frequency of the first amino acid variant relative to all sequences used to construct CYP2 N13 A0 is 29%;

the second amino acid variant is 'L';

the frequency of the second amino acid variant is 23%;

the third amino acid variant is Ά';

the frequency of the third amino acid variant is 21%;

the fourth amino acid variant is 'F';

the frequency of the fourth amino acid variant is 15%;

the fifth amino acid variant is T;

the frequency of the fifth amino acid variant is 4%;

the sixth amino acid variant is 'T';

the frequency of the sixth amino acid variant is 2%;

the last amino acid variant is a deletion;

the frequency of the last amino acid variant is 1%

Only amino acid variants with frequency of 1% of greater are listed. Where the combined frequency of all listed amino acid variants is less than 100%, this is due to the presence of one or more additional variants with frequency of less than 1%.

(0 N3

4:M95-04 5:E36D36A08L08-02V01G01S01M01 6:L41P21A18F03S03V02-02G01T01M01 7:- 48L23S13G05A04W01T01 8:-51G42S01E01 9:-59A14L10T06M03V03l01 10:-95W03 11:- 32T14S10L10A08I08V06F03G02 12:T35V21F10L10S06A05-04I02G01M01 13:V41L26I 18T06A01F01M01-01 14:V28L23A21F15I05T02-01 15:L88I04F02V02-01 16:L41V38A08G03-02T01F01

18:L36V19I16A15T04F02G02-01 19:C50L19W08S03V03G03F02T02-01Y01A01I01 20:L62I 15V13F02M02A01 21:S50L13T12A11V04I02-01C01F01 22:C49G 10V07F06A05L05T05I03S02-01 24:L79M08F04V02W01-01 25:L67V13I11F03A01M01 26:L61F11I06S05V03C02A02W02T01-01 27:L59F15I09M07V04S01 28:S51A13L11F10I04V01-01M01T01W01 29:L38V17A16I07T06F03S03-01R01

30:W74R10P03T02K01L01Q01V01 31:R39K30G11N08L02Q01S01T01

32:Q45K10H09S08R08G05T03N02W01-01 33:S26R22P10I10N05G04M03K03T03V02-01L01 34:-93A03T01 35:-94R03 36:-98G01 37:-90Y05H02 38:S40K18H07R06Y06-04N03Q03A02T01P01

39:G29A12S11K10R06Q06L05-04T03E02N01V01 40:R29K29W11H06G06-04S02Q02Y02L01 42:G72- 10R07E03K02S01 43:-98G01 44:K60R14H10N08Q01 45:L86M06Q02E01F01

50:T58R11F07A07I05V02M01P01W01 51:P90A05T02 52:L89F06I04 54:I50F23L22V03 55:I50L37V09F02 58:L37I32Y09V07F06M04A01T01 59:L88F07M01 61:L52I21V14M10 62:D44N25R11K10E03G01S01 63:T19V16P13R11L11I08S06F03K02M02A01 64:K56G08R07E06Q04D04W04S03N02T01

65:N34D26G 11A08Q06E05K01H01R01 66:I37L30M14T06V04P02F02

67:S25P18L16Y12F07A04D02R01T01V01C01G01N01 68:K53Q11N09E05S04T04R02A02D01L01

69:S82T07G03A01C01H01 70:L60F29I07 71:T24S17M17L14K05Q05R03V02C01E01H01I01N01

72:K45N18R13E08Q04M04A01S01 73:L73F14I08M02 74:S58A19R14Q02G02 75:K48E42Q02D02R01A01 76:K33V19R16E11T07D03Q02A02 77:Y93F04W01 79:P80D10S07 80:V95I03 81:F86Y10M02

83:V52L32I13F01 84:Y68H27R01 85:L65F26M04V01I01 87:P36S22M21T06L06W01R01Q01 88:-95W04 89:R43K27Q14E04D04N01H01 90:P60R33K04 91:V49T28I11A06M01S01 92:V97I01L01 93:V85M08I04 94:L94V03M01 95:H45C28Y12V06S04 97:Y71H15T07Q01 98:E55D22K10Q07N01 99:A80V11T05I02 100:V80I13L04 101:K82R14Q02 102:E96D01Q01 103:A91V07 105:V43I40L09G03D01 106:D88G04N02L01 107:Q47H17L12R11Y03K03N03 108:A46G41K06S03 109:E64D26N07 110:E66D13A11V02N01I01K01 111:F98L01 112:S78A13L02T01G01 113:G86A06D02E01 115:G89A04T01S01

116:S20E19T10H08K07D06N05R05P04A02I02M01Q01 117:F24I20L18M12Q09V04Y03S02N01

118:P65A29S01 119:V33I 17T16L12A06S05M03F03 120:F29L16I14A12V12G04S03T01M01

121:D37E35Q08K04F03H02N02R01S01Y01 122:R28K27P08W08N05A04D03E02Q01G01V01M01T01L01 123:I19L15V14A12T12F06N05H05Y03S01M01 124:F37N24T12K06S05Q02A02V02I01R01L01

125:K41Q27N08-07R06D03E01H01 126:G83D07N02E02 127:Y28L22H14N06F06K05T05R02Q02S01 129:I55V37L06 130:V34I30A18F04L04G03T02 131:F80L06T04I02S01M01 132:S72A17N07T01

133:N87S04H02T01 134:G93N04 135:E59K16N08P07D04T01R01 136:R60T18K05E03I02S02Q01V01L01 137:W90A08 138:K79R14L04 139:Q43E22A08D08V05T04I03H01 140:L52T16I13M11V05

142:R90K03H01N01Q01 143:F97L01 144:S70T14A13 145:L78I11V05M02T01

146:T35M30A12S07L04Q03G01 147:T72I10V09A05 148:L89M09 149:R95K03 150:N53D40S02E01 151:F74L12M07Y05 153:M88V08L01 155:K94R03 156:R70K19Q06 157:S61G18T11E03N02

158:I70V11N07G03M03L02 160:E62D26Q02A02S01N01H01 161:R88L03W02K01Q01 162:I73V26 163:Q89L05K03 164:E85R06A03K01Q01 166:A83S04T04G02V02I01

167:Q29R21G12H10L06S05E04C02K02A01P01 168:C47F29Y13H04S01 169:L97M01

170:V61L24I08M02R01 171:E83A04K03Q02D02G01 172:E60A23R07S01V01Q01 173:L70F17I10

174:R69K12Q08N04H02S01 175:K70G09N08E02D02A01S01T01 176:T83S08Y02F01

177:K31N27Q14E09H07R05 178:G69A19E07S01 179:S28A23Q16R07K06T05L04E03G01

180:P82L07F05S01Y01 181:F40C31I12L08V02Q01 182:D89N07E02 184:T77S08G03I01R01V01Q01L01H01 185:F75L07Y04N03S02I01R01 186:L30I28F21V06Y05M04T01 187:L79F12I06V01

188:S36G33A06H05Q04T03V03I02N01D01 189:C50R18H06S06Q05A02F01K01Y01N01L01G01

190:A63T15I07V06S05G01 191:P42V37T16S01 192:S44C40A10Y01F01 194:V73I26 195:I96V02

196:C75S17A05N01 197:S86D07C02T01 198:I72V18L07 199:V50I32L14T01 200:F98L01

201:G55Q25H08R05N03 202:N27K20D19E13S08L02Q02R02H01 203:R92H06 204:F90Y07L01

205:D74E08S03P03N03G01H01Q01A01 207:E31K29N09D08T07S05Q03R02G01 208:D96N02

209:K43Q21E18P08R03 210:K24E22Q14T10N08D07R05H01 211:F85L07C03G01 212:L83Q09V01H01I01 213:T22R17N16S15A10K06H03Y02D01E01Q01 214:L81I07F04V03M02 215:L40M36I 16V04Q01

216:E21R16D12K12N11Q05S05H04G03Y01T01A01 217:L36M 16K16Y07N05R04A04I03V01

218:F32L23I 18M16A03V03T01 219:N55L07Y07H06E03D03S03G03T01F01

220:E58G 10Q08D08N05K02S01R01 221:N52S19I 10T09V01 222:F56L11V09N06I05A02T02S01G01 223:R22K17Q14E10S06Y05L04I04A03T02H02N01V01 224:I36L30F11E07M04G03Q01

225:L35M18I 12T08V06Q05F04A02S02N01 226:S68N16A09G02T01R01 227:S66T28K01

228:P57S10F10I04H02L02R02T02A02V02G01 229:W70S08T06Q04M02Y01L01

230:G31I24S11L08A07T06M04V02C01 231:Q89E06A01 232:L50V26I07M07T02F02A01

233:Y58C22F12L02H01 234:N59E22D08Q03S03 235:M26N17L14I 11F09A09T04S03V01

236:F83Y08L03W02I01 237:P61S28Y04H01A01 238:S25G12A11T07I05K04N04V04D03W03F03L03R02P01 239:L43I18V15F15Y05 240:L39M32l22-03 241:D38K24Q09H09R06E05N02Y01

242:Y65H16W06P02R01F01C01V01 243:L59F24I05C04V04M01 246:P39S32T08R05A02I02E02K02 247:H87Q10Y01 248:N29R22Q16H11K10T05S01 249:K38Q22R14T08E04N02A01V01H01I01

250:L30I29V16A08F08M04 251:F38L19Y15I09S05M04V01A01T01

252:K63R05Q04N04T03Y03A03G02E02S02H01 253:N63E11L06H05I03R02D02K01Y01

254:L23F20I 19V15Y05M04T03S03A01 255:Q18A18E18D09S07G06T05N05K03L01Y01I01V01

256:E33Y13G09K09D07A04F04T03L02R02N02C01 257:L35I26V15Q07M06T02F02A01

258:K50R12E10N06A04D03L03I01H01Q01 259:D25S17A13N10K09E07Q04T02V02H01R01 260:F62Y33L03 261:I55V20T07A06L04F03M01 262:L39A19S09G08T04M04V03I02K02R01E01F01

263:E56K13R08Q05H04S03D02A02 264:K44R21S11E08Q06I04N01 265:V64I25A04T02L01

266:K56E19Q08R06A03N01M01 267:E51K11Q09R05M05I05D03A02H01L01T01S01 268:H80N18 269:Q66R13E08K06L02H01 270:E43A21K09R07Q07D04G03S01 271:S55T39N01 272:L92F02R01M01 273:D93E01N01Q01 274:P56I 14V08L04T02M02A02H01S01F01 275:N49S29T08D02Q02A01G01H01 276:N43S25C15A06G03D01E01F01 278:-95A04 279:R86Q11K01 280:D96N03 281:F83Y07V04L04 282:I87T06V05 284:C52Y13S12A11T08 285:F78Y12L06M01 287:I60L15S06N05T03M03V02D01

288:K61R22E07Q06H01 289:M88I04L02R01 290:E52Q16D08A07H04K03R02N01 291:Q49K33E16 292:E89D06A01 293:K79Q05N04E03R02-01 294:H31Q14S10K09N09D07G06E05Y01-01

295:N69D13S07H02I02K01 296:P50Q17K09G04A03S03E03H01D01L01T01

297:Q24N21H 14E12D04K04S04L03A02T02 298:S55T29P06L04M01

299:E73H05S03V02K02M01G01L01Q01D01 300:F88Y09 301:T46H23N12Y06D02S02Q01I01

302:M28L21111H09V06Y04T04E04F02D02Q01 303:E44K28D16Q04R02 304:N79T10S05H02G01 305:L89I07M02 306:V34I21L12A11S06T05M04E02F01

307:M17I 15L14T12V10A08R05N02S02G02F01Y01H01 308:T79S11C03A01N01

309:V36T33I 10A08G03S03L02 310:L36S10A10F08T07W06H05V05I04N02M01 311:D53N28S11Y03 312:L89V05M02I01 313:F88L10 314:F48G 16S07L06I06A05V05T02 315:A92G07 317:T95S02I01

318:E86G06V02M01Q01 319:T97S02 320:T66V25S04I01 321:S93G04T01 322:T70S17I03A03L01N01 324:L83I06M05V03 325:R90K05 326:Y85H08F06 327:G74A19S02T02 328:L64F32I02 329:L95S01 330:L68I20V06F02 331:L90M07I01 332:L55M33Q04I03 333:K97R01 334Ύ52Η45Ν01 335:P97T01 336:E59H 13D11K09Q03 337:V68I31 338:T31E27Q23A09V03S01 339:A54E40K01 340:K85R12

341:V68I14L09M04A02 342:Q56H35R03Y02 343:E76K16Q03A02 345:I93L05 346:D75E11N04T02H01 347:R58Q18H09C03S03T01A01N01 348:V95E04 349:I72V22L04 351:R58P14S08K07Q03A03H02 352:H38N24S14D07G04A03E02T01 353:R93Q04 354:S42I11Q09L08A05R04P04V03C03M02K01T01 356:C44A16S14K07T05N02R02G02Q01 357:M48L19V11I09F07Y01 358:Q31E25K12A11D10G03S01N01 360:R92K05H01 361:S39A18T09L07V05M04K03N03G02Q01I01

362:K27R19H 15Q14S06E06A02N02D02C01 363:M89L10 365:Y95F04 366:T84M 12L01S01 367:D78E15N04 369:V90M05T01L01 370:I50V35L13 371:H96C01N01 373:I76V17A03 376:F57Y30L08V01

377:I54A11S09G08L07T05V02 378:D73N10S06A05T03 379:L66I 15F06V06M05 380:V38I34L19A04T01 382:M25L19T17S11N10I 10F02V02 383:G39N38S18A01 384:L57V33I05M02 385:P87A07L01 386:H82R17 387:A41R13T11E08K04M04S03N03V02Y02I02 388:V75A13L04T04I01 389:T73I 12N03L02V02A01S01 390:K31R30Q16C15H01S01T01 391:D91T03N03 392:T60I23V13

393:K39H14Q07C04S04E04R03T03V03M02L02A02P02N01I01 394:F94L04 395:R94Q02K01

396:G47N23D12E10Q06 397:Y83F14H01 398:L40F17V15T11I09H02 399:I72L27 401:K94Q04

402:G84D11N04 403:T96M01 404:T34E23D12V08N05M04A02L01S01I01F01 405:V53I44L01

406:F34I24L20Y13M03V02 407:P64T27A03I02V01 408:S29L26I 14M 11T07V05 409:L96I01M01

410:T31S28G 18D07N04H03C01K01V01 411:S87T08P02 412:V76A12L06I03 413:L91H05M01

414:H51Y17R11K08F02N02T01Q01L01 415:D95E02N01 416:P37S21D19N07E04K01C01G01R01 417:K62Q11R05T04E03S03H03N01 418:E54Y14Q09F08H03V03M01 419:F96W02

420:P53E13S11K08R04A03L03 421:N56K09D09T06Q05Y03S02E01H01R01

423:E50D18Q07N06K05R02G01T01Y01W01H01 424:K20E14T12Q09D08V08A08S04I03M03R02C01 426:D45N39K07Y05H02 428:G50E16Q14D09A02N01R01S01T01 429:H91R04N04 432:D82N16

433:E51A22K12D07G01Q01 434:N48S20K13D06Q04E02G01R01 435:G95Q02

436:N32K12A10R10T10Q09S08C02H01E01 437:F87L11 438:K83R13Q02 439:K88Y07R01S01

440:S65N24T03Q02H02 441:D65E22P06N03 442:Y44A41F06H04G01 444:M57V18L08K07I06445:P82A16 447:S98A01 448:A48I 15T14L08S08M02P01 450:K95R04 452:I41V23A09M08Y06L04N02S01F01

454:L35V31A18F07P04I01 456:E96A01 457:G75S14A08 458:L86I08M04 460:R94K01

461:M82A05T03N03S02 463:L88I09 465:L89I09 466:F71L13Y08I05V01 467:L65F26I05V01

468:T84A05S04V04 469:T56A18S17N03I01 470:I92L03V02 471:L94M04 473:N62H14K09S04A03R02D01 475:T36S23N16R07K07H02C02Q01 476:L81F11V05I01 477:K68S05Q05R05A05E04T01L01G01

478:S55P37C02T01A01 479:L43P26V19S02T01E01Q01A01 480:V63Q07G06I04C03K02M02T02L01E01 481:D48A17P12E05S04H03G02N02L01 482:P84L04H03T02R01 483:K53E18Q11A05D03G03N01R01T01 484:D74E11N04A03S02 485:I78L18V01 486:D80N10S05E01 487:L30I29T26V09F01P01

488:T59S23K05Q03A02I02N01 489:P94A01S01 490:V22K17I 14L10Q08A06T05E05R03M01N01

491:V21A11E11L10T07S07H06I05Y03P03N02F02M01C01 492:S41N22V10T07I06K04C01L01

493:G85S05T04F01A01 494:F51L27V07I05T04M01 495:G42A28V07S04F04T03L03I03N01

496:N37S27K11T08R07H03C01 497:I37V36L16M04A01 498:P96L01 499:P72R19Q02K01H01

500:P20S17T10F09A08N07H05V04R03L03E02K01D01I01 501:Y80F17 502:Q50K20E16T08R01

503:L62I16M 11V06F02 504:C63S17R08Q03I02Y01 505:F61V15L13A07 506:I40L29V14R06T03Q01M01 507:P85A10S02 508:R62V24I02L02H01S01A01

(ii) N8

1:-93M06 2:-93A06 3:-93L06 5:E87D12 6:F59L32S04T02V02 7:S79Y10C04F04T02 8:-95S04 9:-95V04 10:- 95W04 11:T46A26G08S08V08L02 12:T69S26A02M02 13:L83V10F06 14:I65L30V04 15:L95T02V02 16:A51V38S06I02L02 17:-87L12 18:G63L14V12A08T02 19:L89V06A02I02 20:I63L14T14V08 21:L53- 12T12A08S06V06I02 22:A53V26G 10L06S02T02 23:-93L06 24:L91F04C02V02 25:L87M06F04C02

26:W87L12 27:L53F24I 12M 10 28:L51F34I06R06V02 29:S46N30L12W06G02T02

30:V38L20R16G08W06I04A02F02Q02 31:K63R30H02N02Q02 32:N53K12S12-08R06H04T02Y02

33:R24N18-16K14S10E06T06D02G02 34:-97S02 35:-97K02 36:-93G06 37:-95K04 38:R65Q16N06K04S04T04 39:K57R18N16G06H02 40:Y40L16H 12W12R10Q06T02 41:-93L06 42:-95G04 43:-93G06

44:R71H12N06S06A02C02 45:L97F02 50:T34S18P14A10N10L06R06 51:A55P30G 12T02 52:L95F02I02 53:P97S02 54:L91I04F02V02 55:I81L16V02 58195V04 59:L83P14H02 60:Q91T06L02 61:L51I38M06V04 62:D75N14K06E02G02 63:K87T08N02R02 64:K44N32D06S06R04T04A02 65:A73E08Q06V06G04R02 67:F91Y06S02 68:K83R14L02 69:S73T26 70:F48I20L20Y04C02M02V02 71:V42L38M 12F02R02T02 72:K57E42 73:F55L38W06 74:S97R02 75:E42K40Q14D02 76:T83K08S04N02Q02 77Ύ97Η02 79:P95S04 81:M91F06L02 83:V53F16I 14L14M02 84:Y67N14H08W04A02F02K02 85:L75M22I02 87:W71P18S06L02T02 88:-93W06 89:Q97K02 90:R93P06 91:T59V24A10M06 92:V97M02 93:V79A14F04I02 95:V83T08C06L02 98:D81E18 99:A79T16V04 102:E93D06 106:D93N04E02 107:Q91H08 108:A93G06 109:D87E12 110:D93E06 112:T67V18A06S06I02 113:G93S04P02 115:A73G 18M06Q02 116:P91A06R02 117:L36I34T12V08M06F02 118:P97A02 119:F79L12V08 120:L83I08M04F02T02 121:H44Y14F10V10L06N06Q06M02 122:K48R36N14 123:A61P14V14I 10 124:T75N14S04V04L02 125:K61R36N02 126:G85K14 127:Y93F04S02

129:L48I44V04M02 130:G67A20V10I02 131:I73S14V10T02 135:E91S04D02N02 136:R97C02

138:R89K06Q04 144:T97A02 145:L91M08 146:T75S24 149:R97K02 150:D93N06 151:F97L02 155:R93K06 156:K93R06 157:G85R06S06K02 158:M93I06 159:E97D02 160:E77Q20A02 161:W93R06 162:I97V02 164:E97N02 165:E91V06S02 166:S91A06D02 167:K51E20R20Q06S02 168:H83Y12D02V02

169:L79M14I04F02 170:R61V22L06T06F02M02 171:A69D06K06Q06T06G02L02V02

172:R44H30S08A06C02G02K02Q02Y02 173:I77F14M08

(iii) N13

4:M95-04 5:D37E35A09L08-02V01G01S01M01 6:L42P21A18S03V02F02-02G01M01T01 7:- 49L23S11G05A04W01T01 8:-50G43S01E01 9:-58A14L10T06M04V03l01 10:-95W03 11:- 33T14S11L10I08A08V06F03G01 12:T34V21F11L10S05A05-04I02G01M01 13:V41L25I18T06A01M01-01G01 14:V29L23A21F15I04T02-01 15:L87I04F02V02-01 16:L42V38A07G04-02T01F01 18:L37V19I16A16T04F03- 01 19:C52L18W08S04G03V03F02T02-01Y01A01I01 20:L64I13V13F02M02A01

21:S52L12T12A11V04I02C01-01F01M01 22:C50G10V07F06L05T05A04I03S02-01 24:L79M08F04V02W01- 01 25:L66V13I 11F03A01M01 26:L62F11I06S05V03C03A02T01-01 27:L59F15I09M07V04S01

28:S53A14L10F09I04V01-01M01T01W01 29:L39V18A16I07T06F03S01-01R01 30:W76R10P03T02K01Q01 31:R39K29G 12N08L02Q01S01T01 32:Q47K10H09R08S08G05T03W01-01

33:S27R22P10I10N04G04M03T03K03V02-01L01 34:-93A03T01 35:-94R03 36:-98G01 37:-90Y05H02 38:S41K18H07Y06R05-04N03Q02A02T01P01 39:G29A13S11K09R06Q06L05-04T03E02V01

40:R30K30W11H06G06-04S02Q02Y01 42:G74-08R07E03K02S01A01 43:-98G01 44:K61R13H10N08Q01 45:L86M07Q02E01F01 50:T59R11F07A07I05V02M01W01P01 51:P92A03T02 52:L88F06I04

54:I51F23L20V03 55:I49L38V09F02 58:L35I33Y09V07F06M04A01T01 59:L89F07M01 60:Q96H01 61:L52I21V14M10 62:D43N25R12K10E03G01S01 63:T20V17P13R11L11I08S06F03M02A01

64:K56G08R07E07Q04W04D03S03N01T01 65:N35D27G11A07Q06E05K01H01R01

66:I38L31M14T06V05F02 67:S26P18L17Y12F05A05D02R02T01V01C01G01N01

68:K52Q12N09E05S05T04A02R02D01L01 69:S83T06G03A01C01H01 70:L61F29I06

71:T24S18M17L13K05Q05R03C02E01H01I01N01 72:K45N18R13E07Q04M04A01S01 73:L74F13I09M02 74:S57A20R15Q03G02 75:K48E42D02Q01R01A01G01 76:K34V19R16E11T05D04Q02A02 77:Y93F04W01 79:P80D10S07 80:V95I03 81:F88Y10 83:V52L33I13 84:Y68H27R01 85:L65F27M04V01I01

87:P36S23M22T06L06R01Q01 88:-95W04 89:R44K28Q12E04D04N01H01 90:P61R31K04

91:V50T27I11A05M01S01 92:V97I01L01 93:V85M09I04 94:L94V03M01 95:H47C29Y12S04V03

97:Y70H16T07Q01 98:E56D21K10Q07N01 99:A80V11T04I02 100:V80I13L04 101:K82R15Q02

102:E96D01Q01 103:A91V07 105:V42I41L09G03D01 106:D88G05N02L01 107:Q45H18L12R11Y03K03N03 108:A45G42K07S03 109:E66D24N07 110:E68A11D11V02N01I01K01 111:F98L01 112:S80A13L02G01 113:G86A06D02E01 115:G91A03T01S01 116:S21E20T10H08K08D06N05R05A02I02P01M01Q01

117:F24I20L17M12Q09V04Y04S02N01 118:P64A30S01 119:V33I17T17L12A06S05M03F01

120:F30I 15L14A13V12G04S03T01M01Y01 121:D38E36Q08K04F02N02H01R01S01

122:R28K26P08W08N05A04D03E02Q01G01V01M01T01L01S01

123:I19L15V14T12A11F06N05H05Y03S01M01 124:F38N24T10K06S05Q02A02V02I01R01L01

125:K40Q28N08-07R06D03E01H01 126:G83D07N02E02 127:Y26L23H15N07F06K05T05R03Q02S01 129:I55V38L04 130:V34I31A18F05L04T03G01 131:F82L06T04M01S01 132:S71A17N07T02

133:N87S04H03T01 134:G93N04 135:E58K16N08P07D04T01R01 136:R59T19K05E03I02S02Q01V01L01 137:W90A08 138:K81R12L04 139:Q42E23A08D08V05T04I03H01 140:L51T16I13M11V05

142:R90K03H01N01Q01 143:F97L01 144:S72A13T12 145:L78I12V05M02T01

146:T35M31A13S06L05Q03G01 147:T72I10V10A06 148:L88M10 149:R95K03 150:N55D39S02E01 151:F73L12M07Y05 153:M88V08L01 155:K96R01 156:R72K17Q06 157:S62G16T11E04N02

158:I71V11N07G04L02M01 160:E61D27A02Q02S01N01H01 161:R91L03K01Q01C01 162:I72V27

163:Q88L05K03 164:E85R06A03K01Q01 166:A85T05G02S02V02I01 167:Q30R21G 12H10L07S05E03C02A01P01K01D01 168:C48F30Y13H01S01 169:L97M01

170:V62L25I08M02 171:E85K03A02Q02D01G01 172:E61A24R06V01Q01S01 173:L72F17I09

174:R70K12Q08N03H01 175:K71G09N08E02D02A01S01 176:T85S08Y01K01 177:K29N28Q14E09H07R06 178:G69A19E07S01 179:S28A24Q16R07T05K05L04E03G01 180:P81L07F05S01Y01

181:F39C32I 12L08V02Q01 182:D89N07E02 184:T77S08G03I01R01V01H01L01Q01

185:F75L07Y04N03S02I01R01 186:L30I29F20V06Y05M04T01 187:L78F12I06V01

188:S35G34A06H05Q04T03V03I02N01D01 189:C49R18H06S06Q05A02F02K01Y01N01L01G01

190:A64T13I07V07S05G01 191:P43V36T16S01 192:S43C41A11Y01F01 194:V72I26 195:I96V02

196:C74S17A05N01 197:S88D07T01 198:I74V19L05 199:V49I33L15T01 200:F98L01

201:G54Q26H08R05N03 202:N28K21D19E12S08L02R02H01 203:R92H06 204:F89Y07L01

205:D75E08P03N02S02G01H01Q01A01 207:E30K30N09T07D07S05Q03R02G01 208:D96N02

209:K42Q22E19P09R03 210:K24E23Q12T11N08D07R06H01 211:F84L07C03G01 212:L83Q09V01H01I01 213:T23R17N16S15A10K05H02Y01D01 214:L80I07F04V03M02 215:L38M37I 16V04Q01

216:E22R16D13K11N11S05Q05H04G03Y02A01T01 217:L37M 16K16Y07N05R04A04I02V01

218:F33L23I 17M16A03V03T01 219:N56L08Y07H06E04D04G03S01T01F01Q01

220:E59G 11Q08D08N05K02R01S01 221:N53S19T09I09V01D01 222:F57L10V09N06I05A03T02S01 223:R21K17Q14E10S06Y06L04I04A03T02H02N01V01 224:I37L30F09E08M04G03Q01

225:L36M18I 12T08V07Q05F04A02S02 226:S68N16A09G01T01R01 227:S66T29K01

228:P56S10F10I04H02L02R02T02A02V02G01 229:W71S09T06Q04Y01M01F01G01L01

230:G29I25S11L08A07T06M04V03C01 231:Q90E06A01 232:L51V27I07M05T03F02A01

233:Y57C23F13L02H01 234:N58E23D08Q03S03 235:M26N18L14I 10F09A09T04S04V01

236:F82Y08L03W02I01 237:P60S28Y04H01A01 238:S26G12A12T07I06N04K04V04D04F03L03R02W02P01 239:L42I18F16V16Y05 240:L40M30l22-03 241:D38K25Q10H09R06E03N02Y01

242:Y67H16W06P02F01C01V01 243:L58F24I05C04V04M01 246:P39S32T08R05A03I02E02K02

247:H87Q09Y01 248:N30R23Q16K11H09T05S01 249:K39Q22R14T06E04N02V01A01H01I01

250:L31I29V15A09F08M04 251:F36L19Y16I 10S05M04V01A01T01

252:K65R05Q05N04T03Y03E02G02S02A01H01 253:N64E11L06H05I03R02D01

254:L24F21I 17V15M05Y04T03S03A01 255:A18Q18E16D09S08G06T05N05K03L01Y01I01V01

256:E32Y14G09K09D07A04F04T03L02R02N02C01 257:L36I26V15Q07M06T02F02

258:K51E10R10N06A04D03L03I02H01Q01 259:D26S17A13N10K09E07Q05T02V02H01R01 260:F61Y33L03 261:I55V20T07A06L04F03M01 262:L40A19S10G08T04V03M03I02R01F01

263:E57K13R08Q05H04S03D02A02 264:K42R21S12E08Q06I04N01 265:V66I23A04T02L01

266:K57E19Q06R06A03N01M01 267:E50K11Q09R05I05M05D03A02H01L01T01S01 268:H80N18 269:Q67R13E08K05L02H01 270:E44A22K09R07Q06G03D02S01 271:S56T37N01 272:L92F02R01M01 273:D93E01N01Q01 274:P55I 14V08L05T03M03A02H01S01F01 275:N51S27T08Q03D03A01G01H01 276:N44S23C15A06G03E01D01F01 278:-95A04 279:R85Q11K01 280:D96N03 281:F84Y05V04L04 282:I86T06V05 284:C51Y13S12A11T08 285:F78Y13L07M01 287:I59L15S06N05T03M03V02D01

288:K62R20E07Q06H01 289:M89I03L02R01 290:E53Q17D08A07H04K04R02 291:Q48K34E16 292:E89D06A01 293:K79Q05N04E03R02-01 294:H31Q14S10K09N08D06G06E05Y02-01

295:N69D13S07H02I01K01 296:P49Q18K09G04A03E03S03H01D01L01T01

297:Q24N22H 15E13K04D04S03L03A02P01 298:S56T28P06L04M01

299:E72H06S03V02K02M01G01L01Q01D01I01W01 300:F88Y09 301:T47H22N13Y06D03S02Q01I01F01 302:M29L22111H09V06T04E04F02D02Y02Q01 303:E45K28D15Q04R02G01 304:N78T10S05H02G01 305:L88I07M02 306:V33I22L12A11S06T05M04E02

307:M18I 15L15T13V10A07R05N02G02F01S01Y01H01K01 308:T79S11C03A01N01

309:V35T34I 10A08G03S03L02 310:L36S11A11F08T07W06H05V05I04N02 311:D55N26S11Y03

312:L89V05M02I01 313:F88L10 314:F49G 16S08I06A05L05V05T02 315:A91G07 317:T95S02I01 318:E86G06V02M01 319:T97S02 320:T65V26S05I01 321:S92G05T01 322:T72S15I04A03L01N01 324:L85M05I04V03 325:R89K05 326:Y85H08F06 327:G75A17S03T03 328:L63F32I02 330:L69I21V04F02 331:L90M07I01 332:L57M34Q04 333:K97R01 334Ύ52Η45Ν01 335:P97T01 336:E61H13D11K08Q03 337:V69I29 338:T32E27Q21A09V03S02L01 339:A55E39K01 340:K85R12 341:V70I 15L09A02M02 342:Q55H36R04Y02 343:E77K16A02Q01 345:I93L05 346:D75E12N04T02H01

347:R60Q19H09C04S02A01N01 348:V95E04 349:I72V22L04 351:R58P14S08K07Q03A03H02

352:H38N25S15D07G04A03E01T01 353:R93Q04 354:S43I11Q09L09A05R04P04V03M02K01T01 356:C45A17S14K07T05G02R02N02Q01 357:M46L20V11I09F07Y01 358:Q31E24K13A12D10G03S01N01 360:R92K05H01 361:S40A19T09L07V05M04N03G02Q01I01P01

362:K28R19H 16Q14E06S04A03N03D02C01 363:M92L07 365:Y98F01 366:T84M 12L01 367:D78E15N05 369:V89M05T01L01 370:I49V36L13 371:H96C01N01 373:I78V15A03 376:F56Y31L08V01

377:I55A11S09G08L05T05V02 378:D72N10S07A05T03 379:L67I 14F06V06M05 380:V37I35L19A04 382:M25L18T18S11N11I 10V02F01 383:G40N39S16A02 384:L57V34I04M02 385:P87A08L01 386:H81R17 387:A42R13T11E08K04M04S04N03V02I02 388:V77A11L05T04I01 389:T75I 13N03V02A02S01

390:R31K31Q16C15H01S01T01 391:D91T04N03 392:T62I22V13

393:K40H14Q07C05E04R03V03T03M02L02A02P02S02N01I01 394:F94L04 395:R94Q02K01

396:G46N23D12E10Q06 397:Y83F15H01 398:L42F17V15I 10T09H02 399:I71L27 401:K94Q04

402:G85D09N04 403:T96M01 404:T34E24D12V06N05M04A02S01L01I01F01 405:V54I43L01

406:F34I23L20Y14M03V02 407:P63T28A03I02V01 408:S30L25I 14M 11T08V06A01 409:L96I01M01 410:T31S29G 19D07N04C01K01V01 411:S87T08P02 412:V76A12L06I03 413:L91H06M01

414:H53Y18R11K06F02N02T01Q01L01 415:D97N01 416:P38S21D19N07E03K02C01G01R01

417:K62Q11R05T04E03S03H03N01 418:E56Y15F09Q08H03V03M01 420:P54E13S11K08R04L03A01 421:N58K10D09Q05T04Y03S02E02H01R01 423:E52D18Q07N06K05G01T01R01Y01H01

424:K21E15T12Q09D08V08A08I03M03R02S02C01 426:D46N37K07Y05H02

428:G51E16Q12D09A02N01R01S01T01 429:H91R04N04 432:D81N17 433:E52A23K12D07G01 434:N47S21K13D06Q04E02G01R01 435:G95Q03 436:N30K13A10R10T10Q09S08C02H01E01 437:F87L11 438:K83R13Q02 439:K88Y07R01S01 440:S67N22T03Q02H02 441:D67E22P04N03 442:Y46A40F06H04 444:M58V18K07L07I06 445:P82A16 447:S98A01 448:A47I 16T14L08S08M02P01 450:K95R04

452:I42V23M08A07Y06L04N02S01F01 454:L36V29A19F07P04I01 456:E96A01 457:G77S12A08 458:L86I09M04 460:R94K01L01Q01 461:M82A06T03N03S02 463:L88I09 465:L91I07 466:F70L13Y08I05V01 467:L66F27I03V01 468:T86A05S04V01 469:T57A19S15N03I01 470:I94V02L01 471:L94M04

473:N63H14K09S04A03R02 475:T35S23N17R07K07H02C02Q01 476:L83F09V05I01

477:K69Q05R05A05E04S03L01G01T01 478:S56P38T02 479:L45P25V19S01T01Q01E01

480:V64Q07G05I04C03K03M02T02L01 481:D49A17P12E05S04H03N02L01K01 482:P84L04H03T02R01 483:K55E18Q11A05G03N01R01T01 484:D76E11N04A03 485:I78L19V01 486:D81N09S05E02

487:I29L28T26V10F01P01 488:T60S23K05Q03A02N01I01 489:P94A01S01

490:V23K17I 14L10Q08A06T06R03E03M01N01

491:V21A11E11L10T07S07H07I05P03N02F02M01C01Y01D01 492:S39N23V11T08I06K04C01L01

493:G87T04S03F01A01 494:F50L28V07I05T04M01 495:G43A27V07S04F04T03I03L03N01

496:N35S28K11T09R07H03C01 497:I38V36L14M04A02 498:P96L01 499:P74R17Q02K01H01

500:P21S16T11F09A09N07H05V04L03R02E02K01D01I01 501:Y81F17 502:Q51K20E16T08R01

503:L63I14M 11V07F02 504:C65S18R08Q03Y01 505:F62V15L13A05I01 506:I41L29V15R06Q01M01T01 507:P85A10S02 508:R61V25I02L02H01S01A01

(iv) N23

4:M96-03 5:D51E25A12-02S01V01G01Y01 6:L44P31A12V03-01S01F01 7:-55L38W01S01 8:- 55G39E01V01S01 9:-68AllM05T04V04L03l02G01 11:-54T20I 10A06V02G01S01

12:T41V22F18A06S02L02G01I01-01 13:V55I20L12T04A01M01 14:V47A18F15L08I06G01-01

16:V57L31G05A01T01 18:L39V30I 19F03T02A01-01 19:C64W13S06G04T03V01I01-01F01

20:L52V19I19M04F01A01 21:S65A18T05V03L02C01F01I01 22:C69F10T08I03S03V01-01 24:L91W02- 01M01F01 25172115V04F03M01 26:L69F16S07-01 27:L54F24I 12V04S02 28:S65A15F11L02V01T01 29:L52A12I 11V09T07F02S01K01R01 30:W95R02L01 31:R47K36N12T01 32:Q58K11G08S08R04H03 33:S39R15I 15N08G05K03V03T03M01H01 37:-86Y09H03 38:S64H10Y09A03T02R01P01F01N01

39:G44S14A10Q09K06R06E04T01N01 40:K39R36W12G03S03N01 41:-98L01 42:G64-14R10E05K03A01 43:- 97G02 44:K78N11R07 45:L81M09Q04E02 47:P98S01 50:T64F13I08A07V03M01 51:P88A05T03S01 52:L88F10 54:I83L07V05F02 55:I62L18V16F02 58:I52L17V10F06M06A02T01 59:L83F11M02 60:Q96L01 61:L53I30V13M01 62:D52N26K11E03G02 63:V27L18P13T12I 12F05M03A01G01S01

64:K82W06R02T02N02S01 65:N57D36E01H01S01 66:I62L23V07M03F01

67:S43P30A08T03R02D02G02N02C01Q01 68:K65Q12E08A04R01T01S01N01L01G01 69:S82T10H01C01A01 70:L65F23I07M01V01 71:T33S30K08Q06R03C03H02E02N01V01D01G01A01

72:K38N31R09E07M07S02D01 73:L76F19I02M01 74:S64A33G01 75:K62E31Q02R01A01

76:V32K16E14R12T07D06A03Q01S01I01 77:Y92F06 79:P95S03 80:V93I05 81:F90Y08 83:L52V37I09 84Ύ80Η16 85:L53F40V02I01M01 87:M37S30P09L08T07R02Q01 89:K44Q19R13E07D07N03H01

90:P66R24K07 91:T46V31I09A06M02S01 92:V98I01 93:V95I03M01 94:L91V05M02 95:H78Y17I01C01N01 97Ύ91Η07 98:E60D19K15N02Q01 99:A76V17I03T01 100:V89I05L03M01 101:K96R03 102:E96Q01 103:A86V12 105:I64V18L13D02 106:D89N04G02Q01 107:H27Q20L20R17Y06N03 108:G64A16K11S05R01 109:E56D30N12 110:E78D10V04I01N01K01 111:F98L01 112:S71A20L04M01 113:G78A10D03E02S01 114:R98K01 115:G90A03S01N01T01 116:S33H12N09E09R09D06T03I03K03P02A01Q01V01 117:F40L18I 16M12S03V03N02 118:P91A01S01F01 119:V37I24L20A09M05F01

120:F27A21I16L08G08V06S06T02M01N01 121:E40D31Q11K06H02R02S01A01

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135:E42K26N12P11T02R01S01 136:R36T31K08E05I04V02Q02L01S01G01P01 138:K86L07R04

139:Q39E38D13T02A01H01 140:T27I23L19M18V09 142:R95H01Q01 143:F96L02 144:S67A18T11C01 145:L94V02I01 146:M51T34S09L01N01 147:T78V12I05A01 150:N74D20S03 151:F64L13M12Y09 156:R62K25Q08E01 157:S64T16G12N04 158:I79N12L03V02 160:D45E39A03S03Q02N02H01

161:R94K01C01 162:I55V44 164:E83R11K02Q02 166:A85T07S03I02V01

167:R30Q19H17L11E06C04P02S02K01D01 168:C52F24Y14H02S02W01 170:V74L20M02

171:E90K03D02Q01 172:E62A21R11Q01 173:L81I12F05 174:R69K17N06Q01S01H01

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184:T79S07G05Q01H01I01 185:F78N05L04Y04S03I01 186:I46L28F10M06V06T01 187:L85I09F02V01 188:G56S20T05A04V04I03N01F01 189:C74H10F03Y02A02L02G01S01 190:A87V08G01S01

191:P72V20T03S01 192:C68S25Y02F02 194:V87I11 196:C82A08S07 197:S83D12 198:I84V14T01 199:I50V27L20 200:F98L01 201:Q44G24H14R09N05 202:N42K26D15E07R02H02S01 203:R88H10 204:F87Y10 205:D81E09Q02N02H01K01 207:K39N15E15T09S08D05R02Q01 208:D97N01

209:K39Q33E20P03R01 210:K38T16N14D11E06Q03R01H01S01I01 211:F81C05L05G03A01

212:L84Q06V03I01M01H01 213:T30N25R13A08S06K04Y02D02H01G01 214:L82F07I06M02

215:M58I20L15Q02V01A01 216:E35K17N14S07D05G05R03H02Y02M01T01A01

217:L33K27Y12N09R07I02M01H01W01 218:F39L36M09I07V04 219:N70H08E06D06L01R01

220:E83N06D04K02 221:N80I10S02D01C01 222:F42V13L11I09N08A04T04S02M01G01

223:R27K27E17Y10Q04H03N02S01T01L01D01 224:I52L32M07Q02V01R01

225:L56Q09M08V07F07I03S03A02 226:S63N27G02T02R01A01 227:S70T25K01A01

228:P69I06H04S04F02V02R02L02A01G01 229:W86Q07G01I01 230:I42L14G 13T09M07V05A03C02N01 231:Q93E02A01 232:L50V31I11F02M02 233:Y52C37F03H02L01A01 234:N87S05Q05

235:N30F15A15M09L07I06S06T05 236:F86W04L03Y02V01I01 237:P83S14A01

238:A19S16T11I10V07F06N05K05L05D03P02G01R01 239:L56I14F10Y09V07 240:I38L30M20-06R01F01 241:D56H16R07E04K04Q03Y02N01V01C01 242:Y83H05C02W02F02V01 243:L62F18C08I06M01V01Y01 246:S52P24T06E03I02K02R02N01C01 247:H96Y02 248:N42R18K14Q10H10T01

249:K59T11R05E04Q04N03A02V02I01 250:L36I21V18F14M06A01 251:F36L26I15M07S04A02V01Y01T01 252:K77T05E03A03N03Q02R01S01 253:N81E07R03I01Y01H01 254:F27V22I20L04M04Y04T04S04A02H01 255:A29D14E12S12T08N08K02Q02Y02I01V01L01 256:E26Y23K10D07A07F06L04N04G01W01C01H01 257:I28L21V20Q12T04F03M03S01A01C01 258:K68R11D06Q02H02N01E01I01F01

259:S27N15K14A09E09Q08D07H02R01Y01 260:F49Y49 261:I40V28T10L07A06F05 262:L67S13M06A03R02T02F01 263:E84K05D03A03R01 264:K54R20E14I07Q01 265:V52I32A07T04M01 266:K80A05R02E02N02M01Q01T01 267:E78M05K02A02I02D02S01L01R01T01 269:Q77K05E05L03R03H02 270:E54A19K12Q08D02 271:S77T19 272:L95M01 273:D93N02E02 274:P36I24V14L07M05H02A02F02S01 275:N57S18T14D04A02H01 276:N60C24S11D01 279:R82Q16 281:F85Y08L03V02 282:I84T11V02L01 284:C61Y22A10S01T01 285:F78L11Y08M01 286:L97F01 287:I65S10N08M05V03L02T01

288:K78E12R05Q02 289:M86I03R03L03G01Q01 290:E71Q11K06D02R02G01A01 291:Q58K28E13 292:E91A02D01-01 293:K82N07Q03R02-01 294:H51Q08G08D07E06N06Y03K03

295:N73S12H04I02K01R01E01 296:Q27P24K15G07E06A06S04D01T01H01L01

297:Q38E17H11N09K07D05A02P01S01 298:S68P10L08T07M01

299:E66S06V04K03M03L03G02Q01I01W01D01A01 300:F82Y16 301:T72H11N06D04S02I01

302:M26L25117V10T05F04Y03N01E01 303:E69D19K07G01H01 304:N75S09T07H03G02

305:L84I11M01V01 306:I25V22A19S09T08L05M03E01F01K01

307:T21V18I 17A12R09M04N03G03S02F01Y01C01 308:T73S13C05A01L01V01

309:V42T19I 14A10G06L04S01 310:S18A18L14F12W10T09V05N04I02 311:D91N06E01 312:L84V08M04I01 313:F93L04 314:G27F19S13A09I08V07L07T03D01 315:A97G02 317:T94S02I02 318:E84G 11Q01D01 319:T97S02 320:T93S01V01M01L01 321:S96T01 322:T76S09I06L02V01N01A01 324:L83M07I05V02 325:R88K08 326:Y85F08H05 327:G74A20S03 328:L93F03I02 329:L98M01 330:L68I26V03M01 331:L97I02 332:L64M24Q07H01I01 334:H53Y44 335:P96T02 336:E78K07H06D05Q01 337:V60I39

338:T46E22Q15V06A04S03 339:A59E36 341:V66I 14L12A03M01 342:Q69H26R02Y01 343:E85K12 346:D76E14H02N02 347:R65H14Q07C06S03N01 349:I71V27 351:R76P13K03Q03H02

352:H41S23N18D11E02T01 353:R95Q04 354:S65I 12R07K03M02V02L01C01 356:C73A11S10R01

357:M74V11I10 358:Q52K20A19E03S01 360:R91K08 361:S58L11T08N04G04Q03M03A01I01

362:H26Q21R19E10K06S05D04N03C01 363:M96L03 365:Y98F01 366:T77M 19L02 367:D88E06N04 369:V84M09L02T02 370:V61I25L12 373:I79V19 376:Y51F46 377:I89V03L02A01 378:D68N13S09T05A02 379:L85F08I05 380:V43I28L21A03G01 382:T30L21S18N18I04V01M01F01 383:N56S23G 13A03P01 384:L71V24I01M01 385:P92L02 386:H92R07 387:A63E14T12S03K01M01V01 388:V74A19T05

389:T77I08N04A03V03S02 390:R25C25Q24K17H02S02T01 391:D95N04 392:T41I34V22L01

393:K56Q06H05V04M04R04C03E03P03T02I01S01 394:F94L05 395:R93Q03K02 396:N38G22E15D11Q10 397:Y97F01 398:L40V24F18I07T03H01 399:I98L01 402:G90D08 403:T97A01

404:T55V11M06N04A04D03S02L02I02E01H01G01Q01 405:I65V30L02 406:L33I28F24M05V04Y02 407:P48T40A03I03V02 408:S50T13L11V06I05M05A01D01C01 410:T52S28D12K01N01 411:S95P03 412:V84L08I04A01 413:L97M01 414:H61Y24F03K02R02L01 415:D96N02

416:S34D31N12E05K03P03C03G02R01 417:K79Q14R02T01 418:E93Q01Y01A01 420:P90S03K02A01 421:N80D12E02K01H01 422:P98A01 423:E71D07N06K06T02G01H01Y01Q01

424:K33Q15V13E11T08M06I05R03 426:D73N13K11 428:G73E15A03Q02R01H01 432:D70N28

433:E61K20A10D03G02 434:N51S34D04K03G02R01 436:N48K20T16S07A03C01 437:F98L01 438:K82R17 439:K85Y12 440:S91T04N03 441:D85E07N04 442:Y77F10H07A03 444:M72K12V07I03L02F01 445:P73A24 448:A70T19I05L02S01 452:I44V27A12M 11S02N01 454:V47A32L09P07I02 457:G85S08A05 460:R96K01 461:M97V01 463:L83I12M01V01 465:L89I09 466:F71L18I08V01 467:L85F06I05M01 468:T79A09S07V03 469:T58A18S16N03I01 470:I97V01 473:N60H22K15Q01 475:T50N27K11S03I01V01H01 477:K97Q01 478:P49S47 479:L56V30P02T02Q01I01E01A01 480:V81I06T03G03L01 481:D79E07H04N04P01

482:P80H06L04T03R01V01 483:K81Q07E05N02R01 484:D76E14N05K01H01 485:I74L23V01

486:D80N12E03S01 487:T43I35L13V03P01M01 488:T66S19K08I01N01A01 489:P92A03S02N01

490:V38I24L10T09A04E03M01N01K01S01 491:V26A18T12L12S05H04N03F03P02I02D01Q01E01

492:N35S29I10T09K08V03 493:G79T07S06F02A01 494:F50L25T07I07V04N01M01

495:G36A27V11S06I05L04T03N01 496:S46N29H06K05R05C03T01A01 497:V48I24L12M07A03R01 498:P97L01 499:P79R12K03Q01H01 500:P24S23F13H09A06L04R03E02V02T02N01K01Y01D01Q01 501:Y87F11 502:Q48K27E20R01 503:L75V09I07M03F02 504:C83S09R03Y01F01 505:F67V17A08L06 506:I65L18V12T01 508:R43V42L03I03S02A01

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1:-98M01 3:-98L01 4:M93-05 5:E50L21D15-03A03M02G01V01 6:L38A28P06S06F03G03- 02T02W01M01V01D01I01 7:-41S26G12A10T02L02V01 8:G50-42S01W01 9:-42L20A19T10V02M02 10:- 89W09 11:L25S25V11A10F08T05I04-02G02M01 12:L23T23V19S11-10A04I02M02G01

13:L44V21I15T08A02-01S01F01G01 14:L46A26F15T05V02-01I01 15:L73I10F05V05-01M01 16159A15V11- 04F02G02T01 18:A37L34I11T07V02F01-01 19:L43C34V05F05Y03A02-01G01 20:L81I05F04V03-01A01 21:S31L27T23V06I03M02-01A01 22:G26C23V16L13A10I04F01-01T01 23:-98L01 24:L61M19F09V04I01H01 25:L57V26I06A04F01T01 26:L53I14C06A06V06T04F03S02 27:L67M18I03V03F02Y01 28:S35L24A11I09F06- 03M03W02V02 29:V31A23L21T05F05-03S02W01R01I01E01 30:W47R22P07T07K04Q02-02S01

31:G29R29K19L05Q03N02-01A01S01F01W01 32:Q29H18R14K10T08S07W03-01Y01G01

33:R33P26S09M06G03T03I03-02K02L02A01V01W01Q01 34:-85A08T03 35:-86R09Q01 36:-95G02 37:- 95A01T01 38:K45-10R10S07N07Q06H02Y01T01A01L01W01 39:A17L14K12- 11G09S08R07T05I02Q02V01F01H01D01P01 40:R22H16K15G10-10W08Q04Y02S02L01A01E01

42:G88R03S03E01K01 44:K36H24R21N04Q03A02C01 45:L94M03F01 50:T51R28A07W02K02M01P01H01 51:P97A01 52189109 54:F54L38I03Y01V01 55:L67I29F02 58:L63Y21F06I03V03M01 60:Q96H01

61:L50M24V15I08 62:D30R28N22K10E03S01G01 63:T32R28S14P12I02H01L01V01A01

64:G20K18E17R14Q10D09S05N01T01 65:G28A18Q16D13E11K03N03R02H01 66:L43M30T14F04I02V02P01 67:L41Y30F13V03D03I01R01S01 68:K34N22Q12S10T09R03D03L01 69:S83G09A02C01T01 70:L55F37I05 71:M43L32T11Q03I02R01E01 72:K56R19Q09E07A04 73:L70I19F05M02 74:S47R37Q07G03K01H01 75:E60K27D04G02Q01 76:K60R23E07Q03H01T01 77:Y95W02H01 79:P58D27S12 80:V97M01 81:F86Y13 83:V74I18L04F01 84:Y50H44R01W01 85:L82M08F07 87:P76S12T04L03 88:-88W10 89:R90K03Q02S01 90:P55R41Q01 91:V78I13A05C01 92:V94I02L02 93:V70M20I07 94198101 95:C70S11V09Y05W01

96:G97S01 97:Y39H30T18Q03V01P01A01 98:E52D24Q15K03A01S01 99:A85T09V02 100:V66I25L06 101:K61R32Q05 102:E96D03 105:V79G09I07L02 106:D86G08L03 107:Q82K07H05N02R02 108:A87G11 109:E81D17 110:E54A26D11T02V01 112:S93G02A01 115:G93A03T01

116:E36T20K14D07A04M04H02Q02S01P01G01 117:I27Q23L16M13Y08V05F01N01 118:A71P24

119:T42V29S13I07A03M01L01 120:F35L23V22I12Y01T01M01 121:D48E29F07N04Q03K01Y01S01 122:R25P21W18N08K05Q04G04T03S02A01M01 123:L21I17T15V14F13N12W01Y01 124:F76T13V03S02M01 125:Q42K33D08R04N03H02E01 126:G91D03E02S01 127:Y54H22N14F04T01 129:V75I16L06 130:A40V28I12F10T03N01G01 131:F81L12M01Y01 132:S52A43G01T01 133:N89S05T02 134:G96W02 135:E81D09K02N01P01 136:R92S02E01 137:W76A21S01 138:K74R23 139:Q46A17V13I09T08 140:L98M01 142:R84K09N03H01Q01 144:S79T13A06 145:L53I27V09M05T03

146:T36A32L10Q09S03G03V01I01 147:T62I17A13V06 148:L73M25F01 149:R89K09 150:D66N26E03S01 151:F87L11 153:M74V21L02 155:K94T02R02 156:R88K05Q02 157:S60G23E09T05 158:I60V25G10M02L01 160:E95K01 161:R86L09Q01 162:I98V01 163:Q75L12K09 164:E88A09D01 166:A85G07V03T01S01 167:Q47G29S08R06A03 168:C41F39Y13H01N01 169:L96M01 170:V45L32I19M01

171:E78A06Q04K04G03D01 172:E61A28S02M02V02T01 173:L58F37I03 174:R70Q19K04H02

175:K58G19N04A04E04S03D02T01 176:T71S19Y04V01 177:K33Q21E17R12N03H02G01C01I01V01 178:G93E05 179:A56K10E06R06Q03T03G02S02L02V01H01N01 180:P61L16F13Y03N01S01

181:F37I31L17V06Q04M01 182:D89E05N04 183:P97L01 184:T74S11R02L02I02V01K01

185:F71L11Y05R03M01N01S01I01 186:F37L33Y13V07I04P01 187:L68F27I01

188:S56H13Q12A09D02V01N01 189:R44S14C13Q13K04A03N03H01 190:T32A31I18S11V04M01

191:V58T36G01 192:S70A27C01 194:V51I47 195:I91V05M01 196:C64S32N02 197:S95T02 198:I60V26L12 199:V81I07L06T03 201:G98D01 202:D26E20S19K13N07L07Q01R01I01 204:F93Y03L02

205:D67P07E07S05G03N03A02H01 207:E53K15D10Q07T04R03G02S01 208:D95N03

209:K46P17E17R06Q05H01T01 210:E47Q26R12K05T02D02 211:F89L09 212:L81Q15H01R01

213:S28R24A13T13K08N03H03E01 214:L78I09V08M03 215173110V08M06

216:R36D24Q11N07H05E03K03G02S01Y01 217:L43M39A10I02F01K01V01 218:I31M26F24A09L04T01V01 219:N36Y19L17G09F03S03H03T02Q01 220:G27E24Q21D13N03K03S02R01 221:S45T22N14I08V02M02F01 222:F80L09N03V02W01 223:Q28S13R12I10L09A07V04K03T03E01W01 224:L28F23E20I16G09

225:M35I25T20V06L05A03 226:S75A21 227:S61T33K01 228:P37F21S19T04L03R03A03V01

229:W49S21T16Y03M03F01L01 230:G53S28A14T02 231:Q85E12 232:L51V21M10T07F03I02A02

233:Y65F27L03C01Q01 234:E57D21N16F02 235:M52L25I16T02F01V01 236:F76Y17L02

237:S49P26Y11H04A01V01W01 238:S41G29W05R05D04N03K02C01A01P01 239:V28I25F24L21

240:L54M45 241:K55Q20D13R05N02 242:Y43H31W13P06F01K01R01 243:L51F33V08I05

246:P61T12R11A06S03I01 247:H75Q24 248:R30Q24T13N12H07K05S01V01 249:Q49R29K09E04H02 250:I42L23A20V11M01 251:Y37F36L09S06I02Q01V01 252:K47R11Y09Q09N06H04G04S02D01

253:N40E16L16H10I05D03K01M01 254:L53I13F12V05M05Y05T02S01

255:Q43E22G15K05A02L02S02R01D01N01T01 256:E42G21T08K07D07R05C01A01V01 257:L57I22M11V07 258:K27E23N13A11L09R08I02H01 259:D53A19T05V05E04N03L01K01S01R01 260:F79Y10L09

261:I78V07A05T03M03 262:A44G20V09T08S05I04E01D01L01 263:K24R18E18Q13H12S09

264:S29K25R24Q14N04I01 265:V86I10L02 266:E45K24Q14R11

267:K25Q22R12I10E08M05D04H04A01L01T01 268:H53N45 269:Q52R28E12K04

270:E30A26R17G07Q04K04S03D02 271:T65S25N04M01L01 272:L88F06R03 273:D93Q04

274:P84T07A03S02L01 275:N42S41Q07G03E01 276:S41N22A15G09E03F02C01 278:-88A10 279:R90Q04K02C01 280:D92N06 281:F83V07L05Y02 282:I90V09 284:C37S27T19A12 285:F78Y21 287:I50L34T07D03V01A01N01 288:R43K39Q11H04 289:M94I04 290:E27Q25A17D15H09Y01R01

291:K43Q34E22 292:E86D12 293:K74Q09E08R02-01 294:S26Q24K19N12D04E03G02H01-01A01

295:N63D32K01 296:P86Q04H02S02L01 297:N40H20L08S08E06D04Q03G01A01T01K01 298:T58S38 299:E81H 14 300:F97L01 301:H38N22Y14T11Q04S02F02D01 302:M32H21L16E08D06Q03I02T02Y01V01 303:K60Q11E09D08R07 304:N83T15 305:L94M03I01 306:V48L22I 16E04M04S01T01

307:M38L36I 13H02K02N01Y01 308:T87S08N02 309:T57V26S06A05I02L01 310:L68H12I06T04V04F02 311:N56S29Y09 312:L97V01 313:F79L19 314:F94I01L01 315:A83G 15 317:T96S02 318:E88V05M04 319:T96S01 320:V63T23S09I02 321:S87G 11 322:T66S25A06 324:L87V05I03M02 325:R91C01H01K01L01 326:Y85H11F02 327:G77A13T06S02 328:F76L20I01 329:L97R01 330:L72I 12F06V06A01 331:L79M 18 332:M49L46V01 333:K95R03 334Ύ64Η32Ν02 336:E35H25D20K08Q08 337:V83I 16 338:E35Q31A17T10L02 339:A48E44K03Q01V01 340:K66R31 341:V76I 15L05M02 342:H52Q35R06Y04 343:E64K23A05Q03 345:I85L13V01 346:D72E08N08T06I01M01 347:R52Q36A02H01S01 348:V88E10 349:I74V14L10

351:R30S20P17K12A07Q03H02T02 352:N35H35G 10A07S03D01T01Q01 353:R91Q04H01

354:Q22L20A13I 10S09P09V05T03M01R01 356:A25S19K17T12N05G04Q03R03C03M01

357:L48F18V11I08M05Y03S01A01 358:E55D27G07N03S01K01 360:R94H03K01

361:A46S12T11V11M06L02P01G01I01N01R01 362:K59R20A07Q04N02S02H01 363:M86L13 365:Y98F01 366:T95M03 367:D63E29N05 370:I84L14 371:H91C03N02Y01 373:I76V11A09M01 376:F71L21V02C01 377:A25S22G21T11L10I05V01C01 378:D78A10N06S03 379:L41I28V14M 11F03 380:I43V29L16A06T01 382:M61I 18L14V02 383:G79N 12S06D01 384:V49L37I09M03 385:P79A18S01 386:H66R33

387:R34A12T10M08N08K07V04I04S04C01L01 388:V81L12I03T02 389:T74I20N01M01 390:K51R41Q03C02 391:D84T10N02H01 392:T94I03 393:H27K17Q09C07L06A06E05T03R03S03N02P01Y01 394:F95L03 395:R96Q01 396:G81D13E02N01 397:Y61F34H02 398:L43T19F16I 13H03V02 399:L66I32 401:K88Q10 402:G78D10N10 403:T94M01L01 404:E59D25N05T04F02 405:V89I 10 406:F50Y31I 15 407:P85T10A02 408:L47I27M 18V05 409:L92I04M02 410:G47S30N10C04V02T01H01 411:S76T22A01 412:V63A29I02L02S02 413:L82H14Q01M01 414:H41R24K12Y09T03N03Q01 415:D98E01 416:P91S03T01R01

417:K37T10R10S09H09E08Q06A02N02C01 418:Y35F22Q17H08V08M03K01I01

420:E33S22K17R10L06A03P02Q02 421:N24K22Q14T10Y09D06S06H02R01C01E01

423:D36E23Q17N06K04R03G02Y01 424:D22A20E20T17S04K03C03V02N01I01 426:N74Y12D05H05 428:Q28D22G 19E17N03T03S02K01 429:H78R11N09 433:A43E39D13T01 434:N41K28Q11D09E05S01R01 435:G89Q07R01 436:R25Q23A21S10N03C03E03H03K02T01 437:F71L27 438:K85R08Q04

439:K91S03R02N01T01 440:N52S30Q06H05P01I01 441:E44D40P09A01N01 442:A96G02

444:M37V36L14I 11 445:P94A04 446:F98Y01 447:S95A04 448:I31S19L16A14T06M05P03V02 450:K89R09 452:I39V18Y16L11M04N03F03A01 454:L75F19V03P01 456:E92A03D02 457:G64S17A14P01

458:L67I22M09 460:R91K02L02Q01 461:M59A14T08N08S06 463:L94I04 464:F98W01 465:L94I04 466:F70Y20L07I01 467:F59L38V01 468:T97A01 469:T57A20S15N04I01 470:I90V04L02M01 471:L88M 10 473:N69S10A09R06H01K01 475:S53R18T12C05H03Q02K01 476:L59F22V13I04

477:K29A13R13Q11S09E09L03G03T02D02H02 478:S68P21T04F02G01 479:P57L28S04V02T01E01 480:V40Q17G09C09K06M05L02E01S01T01I01 481:A42P29S11D05L02K02E01Q01H01 482:P89L04F01R01 483:E39Q16K15A13G07T02D01S01 484:D75E08A07N03T02 485:I83L13D01 486:D82S10N04

487:L51I21V20F02T01E01 488:T52S30Q09A03K01 489:P97H01 490:K41Q20L11A09R07E03M01T01 491:E27V14S11H11I10L07M03P03C02Y01A01 492:S55V21N06T05C03L03F01I01 494:F51L31V11I03 495:G53A27F09T04S01L01I01 496:N45K20T19R10S02 497:I58V19L18M01 498:P94I02 499:P65R26Q03I01 500:T24P16N15A12V07S06F04E02K02D01I01R01L01 501:Y71F27 502:Q56T21E10K08R01

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31:R46K37N12T01 32:Q59K11S08G07R03H03 33:S40R16I15N07G05V03K03T03M02H01 37:-86Y09H03 38:S64H11Y09A03T02R02P01F01 39:G44S14A10Q09R05K05E04T01N01 40:K40R36W12G03S03N01 41:- 98L01 42:G65-14R11E05K01 43:-96G02 44:K79N09R07 45:L81M09Q04E02 47:P98S01

50:T63F13I08A07V03M01 51:P89A04T03S01 52:L89F09 54:I85L06V05F02 55:I63L16V16F02 57:N98S01 58:I52L17V10F06M06A02T01Y01 59:L83F12M02H01 60:Q96L01 61:L53I30V13M01 62:D53N26K11E04G02 63:V28L18P14I12T11F05M03A01G01S01 64:K83W07R02N02S01T01 65:N57D37H01S01

66:I62L23V07M03F01 67:S44P29A08T03R02D02G02N02C02Q01 68:K66Q12E09A04R01T01L01G01 69:S82T10H01C01A01 70:L65F23I07M01V01 71:T34S30K08Q06R04C03H02E02N01D01G01A01

72:K38N32R09M07E06S02D01 73:L76F19I02M01 74:S64A33 75:K62E31Q02R01A01

76:V33K16E14R12D06T06A03Q01S01I01 77:Y92F06 79:P95S03 80:V93I05 81:F91Y07 83:L51V37I09 84Ύ81Η16 85:L52F41V03I01M01 87:M37S30P09L08T07R02Q01 89:K45Q19R13E07D07N03 90:P66R23K07 91:T47V31I10A06M02 93:V96I02 94:L91V05M02 95:H80Y17C01 97Ύ91Η07 98:E61D17K15N02Q01 99:A76V17I03T01 100:V89I05L03M01 101:K96R03 102:E96Q01 103:A85V12 105:I64V17L14D02

106:D89N04G02Q01 107:H27L21Q21R17Y06N03 108:G64A16K12S04R01 109:E56D29N12

110:E79D11V02I01N01K01 111:F98L01 112:S70A21L04M01 113:G80A10E02D02S01 114:R98K01 115:G89A03S01N01T01V01 116:S34H12N09R09E08D06T03I03K03P02A01Q01V01L01

117:F40L18I 16M11S03V03N01 118:P93A01S01F01 119:V37I24L20A09M05

120:F27A21I16L08G08V06S05T01M01N01 121:E40D31Q11K06H02R02S01A01

122:K41R31D05A05E04N03V02L01W01 123:I21A18V15L12T10H09Y05F02M01S01N01

124:N42K11F10T09S07Q04A03R02I01V01L01 125:K44Q18-13N11R07E01 126:G79D10N03E02

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135:E41K26N12P12T02R01S01 136:R35T32K08E05I04V02Q02L01S01G01P01 138:K86L07R04 139:E39Q39D14A01H01 140:T28I23L19M16V10 142:R95H01Q01V01 143:F96L02 144:S68A19T10C01 145:L94V02I02 146:M52T34S08L01N01 147:T78V13I05A01N01 150:N74D20S03 151:F63L13M12Y09 156:R61K25Q08E01 157:S64T16G12N04D01 158:I80N13L03V01 160:D46E37A03S03Q02N02H01 161:R94K01C01 162:I54V44 163:Q97R01 164:E82R11K02Q02 166:A85T07S03I02V01

167:R30Q19H17L11E06C04P02S02K01D01G01 168:C53F25Y14H02W01 169:L97M01 170:V74L21M02 171:E90K03D02Q01G01 172:E62A20R11Q01 173:L83I 12F03 174:R70K17N06Q01S01H01

175:K80N11G01D01E01S01 176:T96S01K01 177:N45K26H10Q10E04R01 178:G53A32E09S01

179:S47Q25R08T06L06K02A01M01 180:P95S01L01A01 181:C55F39L01 182:D89N09

184:T80S07G05Q01H01 185:F79N05L04S03Y02I01 186:I47L26F10M06V06T01 187:L85I09F02V01 188:G56S20T05A04I03V03N01F01 189:C76H10F03Y02A02G01S01 190:A86V08G01S01T01

191:P74V19T03S01 192:C69S24Y02F02 194:V88I10 196:C81A08S07 197:S83D12 198:I84V14T01

199:I50V27L21 200:F98L01 201:Q45G22H15R09N05 202:N43K27D15E05R02H02S01 203:R88H10 204:F87Y10 205:D81E09Q02N02H01K01 207:K40N15E13T09S08D05R02Q01 208:D97N01

209:K40Q33E18P03R01 210:K37T16N14D11E06Q03H01R01S01I01V01 211:F81C05L05G03A01

212:L85Q06V03I01H01 213:T29N26R13A08S05K04Y03D02H01G01Q01 214:L82F07I06M02

215:M59I20L14Q02V01A01 216:E35K17N15S07D05G05R03H03Y02T01A01

217:L33K27Y11N09R07I03M01H01W01T01V01 218:F40L35M09I07V04 219:N71H09E06D06L01

220:E83N06D04K02 221:N81I09S02D01C01G01 222:F42V13L11N08I08A04T04S02M01G01

223:R27K26E17Y10Q04H03N02S01T01L01D01 224:I52L31M07Q02V01R01

225:L56Q10M08V07F07I03S02A02 226:S64N26G02T02R01A01Q01 227:S69T25K01A01

228:P70I06H04S04V02R02L02A01G01F01 229:W87Q07G01 230:I43L14G12T09M07V05A03C02N01 231:Q94E02A01 232:L50V32I12F02M02 233:Y53C38F02H02A01 234:N87Q05S05

235:N31A15F14M09I07L07S06T05 236:F86W04L03Y02V01I01 237:P83S14A01

238:A20S16T11I10V07F06K05L05N04D03P02G01R01 239:L56I14F10Y09V07 240:I38L30M21-06R01 241:D57H16R07E05K04Y02Q02N02V01 242:Y83H05C02W02F02V01 243:L63F18C08I04M01V01Y01 246:S53P23T06E03I03K03R02N01C01 247:H96Y02 248:N43R18K14H10Q09T01

249:K60T11R05E04Q04A02V02N02I01D01H01 250:L36I20V18F14M06A01

251:F35L26115M07S04A02V01Y01T01 252:K78T04E03A03N03Q02R01S01 253:N82E07R03I01H01D01 254:F26V22I20M04L04Y04T04S04A03H01 255:A30D13E13S12T08N07K02Q02Y02I01V01L01

256:E26Y24K09D07A07F06L04N04G01W01C01H01 257:I29V21L20Q12T04F03M03S01A01C01

258:K68R11D06Q02H02N02E01I01F01 259:S28N15K14A09E08Q08D07H02R01Y01 260:Y50F48

261:I41V27T10L07A06F05 262:L68S13M06A03R02F01T01 263:E85K05A03D02R01G01

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267:E79M05K02I02D02A01L01R01T01Q01 269:Q79E05K04L03R03H02 270:E55A19K12Q08D01

271:S79T17 272:L95M02 273:D93N02E02 274:P37I25V14L07M05H02F02A01S01

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282:I84T11V02L01 284:C60Y22A11S01T01 285:F77L12Y08M01 286:L96F01 287:I65S11N08M05V03L02T01 288:K79E12R04Q02 289:M86I03R03L03G01Q01 290:E71Q11K06D02R02G01A01 291:Q58K28E12 292:E90A02D02-01G01 293:K82N07Q03R03-01 294:H52Q08G08D07E06N05Y03K03C01

295:N72S12H04I02K02R01E01 296:Q27P23K15G07E06A06S04D02T01H01L01N01

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299:E65S06V04K03M03L03G02Q02I01W01D01A01 300:F81Y16 301:T73H09N06D03S02I01

302:M27L26I 18V10T05F04Y02E01 303:E69D19K07G01H01 304:N74S09T07H03G02 305:L84I 12M01V01 306:I26V23A19S09T09L05M04E01K01 307:T21V18I 17A12R10M05N03G02S02F02Y01C01

308:T74S14C05A01L01I01M01 309:V43T19I 13A10G06L03S01 310:S19A18L13F11W10T09V05N04I02G01 311:D91N06E01 312:L84V09M04I01 313:F93L04V01 314:G27F18S13A10I08V08L07T03D01 315:A97G02 317:T94S02I02 318:E84G 11Q01D01 319:T97S02 320:T93V01M01S01L01 321:S96T01

322:T78S09I06L02N01A01V01 324:L83M07I05V02 325:R88K08S01 326:Y84F08H05 327:G75A19S03 328:L94I02F02 329:L98M01 330:L69I25V03M01 331:L97I02 332:L63M25Q07H01I01 334:H54Y43F01 335:P96T02 336:E78K07H06D05Q01 337:V61I38 338:T47E22Q13V06A04S03 339:A61E35

341:V66I14L13A03M02 342:Q70H25R02 343:E86K11 346:D76E14H02N02A01 347:R66H14C06Q06S03N01 349:I70V28 351:R78P13K03H02Q01 352:H41S23N17D10E02T02 353:R95Q04

354:S67I 12R07K03M02V02L01 355:P97A01 356:C75A11S09R01G01 357:M75I 10V10L01

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362:H26Q22R19E10S05K05D04N03C01 363:M96L03 365:Y98F01 366:T77M 19L02 367:D89E04N04 369:V84M09L02T02 370:V62I24L12 373:I80V18 376:Y52F46 377:I91V03L02T01 378:D67N13S09T05A02 379:L86F08I03 380:V43I29L21A03G01 382:T30L21S19N18I04V01F01M01 383:N57S24G 11A03P01 384:L71V24I01M01 385:P93L02V01 386:H92R06 387:A62E14T12S03K01M01V01 388:V75A18T05 389:T78I08N04A03V03S01 390:R26C25Q24K16H02S02T01 391:D95N04 392:T40I35V22L01

393:K57Q06H06V05M04R04C03E03P03I01S01T01 394:F94L04 395:R93Q03K02 396:N39G20E15D11Q11 397:Y97F02 398:L41V25F19I08T03H01 399:I98L01 402:G90D08 403:T97A01

404:T56V11M06N05A04D03S02I02L01E01H01G01Q01 405:I65V31L02 406:L34I29F22M05V04Y02 407:P47T40A04I03V02 408:S51T13L11I06V05M05A01D01C01 410:T51S29D13K01N01Q01 411:S95P03 412:V84L08I04A01 413:L97M01 414:H62Y24F03R02L01K01N01 415:D95N02

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18:L91A02F02T01 19:L88G05A03C01 20:L82I08A01C01S01 21:L88S05I02A01 22:A63L26G03C02 23:-95L04 24:L72V17F02I02M02 25:L37V33I14T10 26:C49A20L08S08Y05V02F01M01 28:F44A22L14S12V02M01 29:L73W11R09A01S01V01 30:T52W20R09I06A02M01Q01 31:L38G19R18F09M02W02S01

32:S41W19G07K07T07N05R03A01H01V01 33:S58G25R05A02L01P01V01 34:-70A23V01 35:- 74R13Q05K03H02 36:-68G20R06Q02 37:-68A10T10K05S01 38:R62Q16K07W07-01

39:G48T16R13D07M04S02-01 40:K64R21Q10 41:-95L04 42:G83S06K02R02E01 43:-95G04

44:R49Q19A12K06G04D02H01 50:R48T25K17A07M01 51:P98A01 52:L98F01 54:L69F13I13V02 55:L95F01 58:L98Y01 60:Q96-01 61:L95F01I01 62:R60E16D10Q05N02 63:S84T09P04 64:Q58R18G12K08

65:D60R15E04G04H04A03N03Q01 66:M53L42P03 67:L63D24Y03V02F01H01 68:T60R20K10S02N01Q01 69:S75A15V05 70:L93F04Y01 71:T63M34 72:K74E24 73:L97V01 74:S95T01 75:K65G14E06S04R03Q02 76:E50R23K21 77:Y75W21F01 79:S59P34A02 80:V95M03 81:Y53F43-01 84:H47Y26R13W11 87:P80S14T01 88:-94W05 89:R82Q10G01K01L01 90:R57P39Q01 91:V75A21 92:V96I02 95:S65C33

98:Q59E16A08S08D01T01 99:A78T20 100:V75L24 101:K74R25 102:E75D24 106:D73L23N02

107:Q82K10H06 108:G59A38 109:E68D30 110:E62A12D10T10-01 115:G96A02 116:D47A22S11E08K02- 01G01H01 117Ύ63Μ24Ι04-01 118:P75A20-01 119:V86A03-01S01 120:F91L06V01

121:F52E19Y08D06L04Q04 122:N60R31 123:F91I05L01 124:T96F02 125:K71R19H04Q01 127:N90Y06 129:I90L05V03 130:A70V27 131:F97V02 133:N95D02S01 134:G96R01 135:E46D27P13R05H01N01 136:R94K03 138:K73R17L03H01Q01 139:V48T22A17Q06I03 142:R68N22K06T01 143:F95L01Y01 144:S69A25T04 145:V47L38I10M02 146:Q65G23T08H01 147:I59A23T16 148:L97-01 149:R73K22-01H01 150:N72E21D02K01 151:F93L04 152:G97R01 153:M76L13V08 155:K73T17N03R03 156:R91S03K02 157:S78T20 158:I92L01M01V01 160:E92A01D01K01 161:R91Q04H01 162:I95V04 163:L81Q15

166:G52A38S03V01 167:S49A22R10Q09G02D01 168:F65C27Y05 169:L96V03 170:L80V12I03M01 171:A33E33G 18Q06D04 172:E85V09A03 173:L67F31 174:R64Q27S03K01 175:K69A23E02G01N01 177:E57K10I07V06D04Q03M02T02A01 178:G97A01 179:E36K26A25Q04T02V02 180:P98L01 181:F96L02 182:D86N10 184:T50R21V10K06L05-01I01 185:F71R21Q02S01 186:V50L32I07M05 187:L96I01V01 188:S74D21G01R01 189:R69N23C05 190:S65A33 192:S96A01C01 194:I66V33 197:S95T02A01 198:V93I05 199:V45L28I25 202:S62K13N09E07Q02R01 204:F75Y24 205:D73G17H04E01N01 207:D53E27G14T01 208:D98-01 209:E58P24K08D03-01A01 210:R64E22D03K03Q02-01 211:L64F33-01 212:L93R02-01 213:T72R23A01N01 214:I63L35 215:I62L33V01 216:R38D24H19N08Q02S02 217:L80F11I03V01 218:I71F25L01M01 219:N81H12S05 220:D83E15 221:N92I01T01Y01 223:Q69R22K02S01 224:I93L03F02 225:M93L02V02 227:S92G04T01 228:P70R22Q01 231:E90Q07 232:M50L37I02T02F01W01 234:N96H01 235:I88L06M02V01 238:S82G06N03R03 239:L89F05V02I01 240:L88M 11 241:D93N02 242:W92H05 243:V50L36I10 248:R50H31Q14N01 249:R89K06 250:L54I37M06 252:Q58R25K07A03 254:F76Y18V03 255:G57E12A08T07Q04R04K03 256:R36E22C12G 10K10S02N01 257:M50L39V10 258:K70R27Q01 259:D61V19A05E05L02H01 260:L65F33 262:A67S25R02T01 263:R48E32H09C02G02 264:S60Q24R07I05 265:V70I28 266:R61Q24H04K03E02C01 267:E34D31R22M02Q02W02 269:Q84R13 270:A50Q20D13E12 271:S65T29 272:L72R23F01I01 273:D75Q24 274:P92T02A01S01 275:N52G 19S12E05R04D03

276:S72E22C01 278:-94A05 279:R96Q01 281:F95Y03 284:C97Y01 285:F98-01 287:T52D22I 12N06A01S01 288:K74Q24R01 289:M92I07 290:A63D21E12T01 291:Q69K23E07 293:K73Q22H01 294:Q81K09E07 295:D92N06 296:P96A01L01 297:L54E21H08N05Q04 298:S97T01 299:H92E05Y01

301:H45Q28Y09N07F05C01 302:M71E15D05L03Y02 303:D61E37 304:T94N05 306:L62V36 309:T97V02 310:H92L03F02 311:N97D01 313:L61F33I04 315:G92A06 318:E97K01 320:V64T33 321:G61S37 322:T98I01 324:L96M02 325:R96H01 326:H61Y36F01 327:A56G29S06T06 328:F71L27 330:I44V44A07L02 331:L95M04 332:M67L27Q01 334:Y98F01 336:K55E35H03Q02 337:V87I 11 338:Q74A25 339:A86E07V04 340:R64K32 341:V94I02 342:Q92H07 343:E75A19Q02K01 344:E98-01 345:I77L20-01 346:D98-01 347:R66A19S05- 01C01L01 348:V96T02 349:V88I 10 351:R94H01Q01 352:A57S16T07N05M04D03E01 353:R95H01W01 354:L51A13T09S08M07R05P01 355:P98A01 356:A27T23S21R18C04-01 357:L81M06V06-01

358:E81D09A02-01G01K01 359:D97-01 361:A67S07V07E05K03P02T02 362:A52R22S10K04H03N02C01 363:M75L25 367:D75N24 369:V96-01M01 370:I77L22 372:E98-01 373:V65I33 377:A66I29L02 378:D74S25 379:V65I32L01 380:I64L25V06-01 382:M75L24 383:N62G29S07 386:H76R23 387:R65A28M02 388:V74L25 389:T73I25 390:R94Q04 392:T95V02A01 393:A42H25P09N08V03D02E01Q01T01 394:F77L22

395:R92H02K01Q01 396:G93N02S02 397:F67Y16H 15 398:L67F21T07 399:L68I30 400:P94H03

402:G95D02S01 404:D65F20N06T04M01 405:V82I17 406:I96F02 407:T66P33 408:L98V01

410:N65V19S09A01M01 411:T66S32 412:V75A16S07 413:H93L06 414:Y61R21H 10Q04 416:P91S08 417:S55T29D06K05 419:F97W02 420:L48K43V02Q01R01 421:T52D25K11N07 423:Q56D22E09K02R02H01 424:E58C15K06H04A03S03T03 428:E64T18G04N04D03A01S01 429:H75N24 433:A56D29E11

434:N66K24R03S02 435:Q54G31R06E01S01 436:S68E21A02C02T01 438:K75Q23 439:K73S16N08 440:S59N37 441:P65D28E04 447:S74A25 448:A74P23L02 450:R62K33S01 452:L60M25I07Q02V02 456:E73A25 457:S53G31P12A01 460:R96-01 461:M75S22 463:L73I25 465:L95I03 466:Y54F45 467:L80F19 468:T96A01S01 469:A73T15S10 470:I92L04T01 473:S40N25R18K07H03-01 475:S47T31C16R01 476:L95F04 477:Q62L23H03K03R03E01 478:P97S01 479:L74V18T02-01 480:G66V19E08-01C01

481:A57S20D07E06K02N01 483:E76A20S01 484:D63N18E12S03 486:D94N05 487198101 488:T96S02 490:L61Q25E03I03A01R01 491:S64C18V06Y06G01 492:S71T27 494:L93F05 496:N96K02

497:L54V28I12M03 499:R74P25 500:P75A19S02 501:F89Y10 502:Q90E07 503:L85M 11 504:C57R31H06S01 505:L68V14M08A05I01 506:R54V28I04S03L02 507:A62P19T05I02E01L01M01

(viii) N38

1:-98M01 2:-98A01 3:-98L01 4:M95-03 5:E57L24D06A03-02M01G01 6:L43A32P07F04W02T01V01D01G01- 01101 7:-32S29G14A12T02L02V02 8:G58-33S02W01 9:-33L23A22T12V02M02 10:-88W10

11:S28L28A11F09V08T03I03G02-01W01 12:L26T25V22-12A04S04I03 13:L50V24I17-01F01G01

14:L52A20F17T02V02-01 15:L82F06V03I02-02M01 16:L54A18V12-05F02G02T01 18:A42L26I13T08V03- 01F01M01S01 19:C39L36V06F06Y03-02A01 20:L81F05I04V04-01A01 21:S36T26L17V07I03M02-02A01 22:G30C26V18L11I04F01A01-01T01 23:-98L01 24:L59M21F10V02I01H01 25:L61V24A04I04F01

26:L60I16V06T05A03F03S01 27:L62M21I03V03F03Y01 28:S38L26I11A09-03M03W02V01T01

29:V36A26L13T06F05-04S02I01E01 30:W52R24P09K04Q02-02S02 31:R31G30K22Q04N02-02A01S01 32:Q33H21R15K11T08-02S01Y01W01 33:R38P30M07T04I04-03K02L02Q01W01A01S01V01 34:-88A06T04 35:-88R09P01 38:K51-12S08N08Q04H03R02Y02T01A01L01 39:A19L16K14- 13S08R07T04G02I02Q02V02F01H01P01 40:R23H18-12G12W10K07Q03Y03S02L02A01E01

42:G89R03S02E01 44:K41H28R18N05C01Q01 45:L93M03F02 50:T56R25A07W03P01M01H01I01 51:P97A01 52188111 54:F60L34I01Y01 55:L63I33F02 58:L58Y24F07I04V03M01 60:Q96H01

61:L43M28V17I09 62:D34N25R23K11S01E01G01 63:T36R32P13S03I02H02L01V01A01Q01

64:G21K20E19R13D11S05Q02N01T01 65:G32A21Q19E12D05K03N02 66:L43M26T17F04I03V02P01 67:L38Y35F15V03I02R01S01 68:K38N25Q13S11D03L01R01T01 69:S84G11C01T01 70:L49F43I06

71:M45L37Q03T03I03R02E01K01 72:K53R22Q11A05E05 73:L66I22F06M03 74:R42S39Q08G03K02H01 75:E68K21D05Q02 76:K67R22Q03T01H01 77Ύ98Η01 79:P62D30S04 80:V97M01I01 81:F93Y06

83:V70I20L05F02 84Ύ55Η43 85:L80M09F08 87:P75S13T05L03 88:-87W12 89:R90K03Q02S01

90:P57R38Q01 91:V78I15A02C01 92:V94I02L02 93:V66M23I08 94:L98I01 95:C77V11Y06S02W01 96:G97S01 97:H34Y31T21Q04V01P01A01I01 98:E58D27Q08K03 99:A87T07V03 100:V65I28L03

101:K59R33Q06 105:V76G10I08L03 106:D88G09 107:Q81K06H05N02R02 108:A94G04 109:E83D15 110:E53A28D11V01 112:S93G02A01N01 115:G92A03T01 116:E40T23K16M04H02A02Q02D01P01 117:I31Q26L19M11V06F01N01 118:A79P16T01V01 119:T48V20S15I08A03M01L01

120:L26F26V25I14Y02T01M01 121:D54E30N05Q04K01S01 122:R25P24W21K06Q05G04T03S02A02M01 123:L24I19T17V17N14W01F01Y01S01 124:F87V03S03M01I01T01 125:Q49K28D09N04H02E02R02 126:G89D04E03S01 127:Y63H25F04T02N01 129:V86L06I05 130:A34V29I14F11T04N01G01S01

131:F78L14M01Y01 132:A50S45G02T01 133:N88S06T03 134:G96W02 135:E87D06K03N01

136:R92S03E01C01 137:W73A24S01 138:K74R24 139:Q53A17I10V07T06P01 140:L97M01

142:R86K09H01Q01 144:S80T15A03 145:L56I29M05T04V03 146:T41A36L12S03V01I01 147:T69A11I10V07 148:L69M28F01 149:R92K06 150:D76N19E01S01 151:F86L12 153:M73V23F01 155:K97R01

156:R88K06Q02 157:S57G26E11T02 158:I55V29G11M02 160:E95K01 161:R85L10Q01 163:Q85K10L01 164:E86A10D01 166:A93V03T01 167:Q54G33R05S02A01 168:C43F35Y15H01N01R01 169:L97M01 170:V51L24I21M01 171:E85K04Q04A01D01 172:E57A32M02S02T01 173156F38I04 174:R70Q18K05H03 175:K56G22N05E04S03D03A01T01 176:T67S22Y05V01 177:K37Q24R14E10N04H03G02C01 178:G92E05 179:A61K07R07Q04T03G03S03L02E01H01N01 180:P55L19F15Y03N02S01A01 181:I36F28L20V07Q05M01 182:D89E05N03 183:P97L01 184:T78S12I02L02 185:F71L13Y06M01N01I01S01V01 186:F42L34Y15I03P01 187:L64F31I01M01 188:S54H15Q13A10V01N01 189:R40S16C15Q15K05A04H01

190:T37A31I21V05S02M01C01 191:V52T41G02M01 192:S66A30C01 194:V55I44 195:I90V06M01 196:C59S37N02 197:S95T02L01 198:I69V15L14 199:V87I04T03L03 201:G98D01

202:D30E22K13S12L08N07Q01I01R01 204:F96L02 205:D66P09E08S06A03N03G01H01

207:E58K17Q08T05R03D03S01 208:D95N04 209:K52P16E10R07Q06H02T01

210:E51Q30K05R03T02D01C01 211:F98L01 212:L79Q17H01 213:S33R25A15K09T04N03H03E01Q01 214:L85V09M03I01 215:L79V09M07I02 216:R35D24Q13N08H03E03K03G02Y01S01A01

217:M45L36A11I02K01 218:M30I25F24A11L04T02V01 219:N29Y22L19G 10F04T03S02Q01H01M01 220:G31E26Q24N03K03S02R02D02 221:S51T25I09V03M02N02F01L01 222:F77L10N03V02W02K01 223:Q21S15I 11R11L10A08V05K04T04E01W01 224132F27E23G 11103 225:I29M26T23V07L05A04G01 226:S72A24 227:S57T38K01 228:P33F25S22T05L04A03V01I01 229:W41S24T19Y04M03F01L01

230:G46S32A16T03 232:L54V24T08M03F03A02I02 233:Y59F31L04C01Q01 234:E66D24N04F02

235:M59L28I05T02F01V01 236:F73Y20L03I01 237:S57P15Y13H05A01V01W01E01

238:S34G32W06R05D05K03N03C02P01A01 239:V32I28F27L10 240:M50L48 241:K64Q23R06N02D01 242:Y50H36P07F01K01R01 243154F38I04V01 246:P56T14R12A07S03I01 247:H71Q27

248:R27Q26T15N13K06H04S01V01 249:Q57R19K10E05H03 250:I43A23L18V12

251:Y43F26L10S07I02Q01V01T01 252:K53Y10R09N07H05G05S03D01Q01

253:N31E19L18H 12I06D03K02M01 254:L61I 15V06M05Y03T02F01S01

255:Q49E24G08K05L02S02D01A01N01 256:E44G23T10D08K07A01V01 257:L61I25V07M05

258:E27K21N15A13L10R05I02H01 259:D52A21T06E04N03V03K01L01S01R01 260:F87Y12

261:I75V08A06T04M04 262:A40G23V10T09I05E02S01D01L01 263:K28E16Q15R14H 12S10

264:K29R26S24Q12N04 265:V89I07L02 266:E52K28Q13R03 267:K29Q25I 11R11M06H04E04A02L01T01 268:N51H46 269:Q47R30E14K05 270:E33A22R20G08K04S03Q02D01 271:T71S18N04M01L01 272:L91F07 273:D96Q01 274:P82T07A03S02L01C01 275:S45N41Q08 276:S37N25A17G 11F02C01H01 278:-86A12 279:R89Q04K03C01 280:D92N07 281:F81V07L06Y03 282:I88V11 284:S31C28T22A14V01 285:F75Y24 287:I57L39V01 288:R49K34Q09H04 289:M94I03 290:E29Q28D14A10H10Y01R01 291:K45Q28E24 292:E84D14 293:K74E09Q07R02-01 294:S30K21Q15N14D05G03E02H02-01A01 295:N73D22K01 296:P84Q05H03S02 297:N46H22S09D04E03Q03G01A01T01K01L01Y01 298:T67S30 299:E93H02

300:F97L01 301:H37N24Y15T13S03F01D01 302:M26H25L18E07D06Q04I02T02Y01V01F01

303:K69Q13R08E06T01 304:N96T02 305:L93M03I01 306:V51I 18L16E05M04S01T01

307:L42M29I 15H02K02N01Y01 308:T85S10N03 309:T50V30S07A06I03L01 310:L78I07T04V04F03 311:N50S33Y11 312:L97V01 313:F87L12 314:F93I02L01 315:A95G03 317:T96S02 318:E86V06M05 319:T96S02 320:V62T22S11I03 321:S95G03 322:T61S28A07N01 324:L85V06I03M02

325:R90C02K01H01G01L01 326:Y93H03F02 327:G84T06A06S02 328:F76L20I02 329:L97R01 330:L82I08F07 331177M21 332150M46V01 333:K94R04I01 334Ύ59Η37Ν02 336:E35H28D23Q08 337:V81I 17

338:E41Q24A16T12L02 339:E50A42K03Q01 340:K72R25Q01 341:V74I 17L05M02 342:H59Q27R07Y05 343:E63K27Q03A02 345:I86L11V01 346:D69E09N09T07I01M01 347:R51Q42H01S01 348:V87E11 349:I85L11V02 351:S23R21P19K14A09Q04H03T02 352:H40N40G 12D02Q01S01 353:R91Q05H01 354:Q26L15A13I 11P10S10V06T02H01 356:A25K20S19T11N05G05Q04C03R01M01

357:L42F21V12I09M06Y04S01A01 358:E51D29G08N03S02K01 360:R93H03K02 361:A43S13T12V11M07L02I01N01R01G01P01 362:K68R20Q05N02 363:M88L11 365:Y98F01 366:T95M03 367:D61E33N02Q01 370:I85L13 371:H90C03N03Y01 373:I83A11V02M01 376:F67L24V03C01Y01 377:S25G24A18T13L12I01V01C01 378:D79A11N07 379:L48I27M13V06F03 380:I40V34L15A07T01 382:M59I21L13V03 383:G86S06N04D01 384:V56L27I10M04 385:P76A21S01 386:H64R34

387:R29T12A10M09N09K09V05I05S04C02L01 388:V82L10I03T02 389:T74I19N01M01 390:K59R32Q03C02 391:D82T11N02H01 392:T94I04 393:H28K20Q10C08L07E06R03S03T03N01Y01 395:R97Q01

396:G79D16E02N01 397:Y69F29 398:L39T21F15I15H03V02 399:L65I33 401:K87Q12 402:G75D12N11 403:T94M02L02 404:E67D19N05T04 405:V90I09 406:F57Y36I03 407:P94A02T01L01 408:L39I31M21V05 409:L91I05M02 410:G54S34C04T02N01H01 411:S83T14A01 412:V61A31I02L02S01 413:L94Q02M01H01 414:H46R24K14T04N04Q01Y01A01F01 415:D98E01 416:P91S02T01R01

417:K43R11H10E09Q07T07A02N02S02C01 418:Y40F25H10V09Q05M03K01I01

420:E38S26K13R11A03P02Q02 421:N27K23Q16Y10S07T03D02H02R02C01E01

423:D38E26Q11N07K04R03G02Y01T01 424:D25A23T20E14S04K02V02N01I01C01 426:N70Y14D06H06 428:Q32D25G22E10N02S02K01 429:H79R13N07 433:E44A40D11T01 434:N37K28Q13D10E06S01 436:R29Q26A24N04H03C03K02S01 437:F67L31 438:K87R10Q01 439:K94R02T01

440:N54S25Q07H06P02I01 441:E50D42A01N01P01 442:A95G02 444:V41M27L17I13 445:P94A05 446:F98Y01 448:I36S21L18T07M06A05V02 450:K98R01 452:I43V21Y18N04F03L03A01M01

454:L72F22V03P01 456:E95D02K01 457:G69A16S11M01 458:L62I26M10 460:R90K03L02Q01

461:M57A17T10N09S04 463:L98I01 464:F98W01 465:L94I04 466:F74Y15L08I01 467:F65L31V02

468:T97A01 469:T64S15A11N05I02 470:I89V04L02M02 471:L86M12I01 473:N75A10S05R04H01K01 475:S54R20T09H04C03Q02K01N01 476:L53F25V15I04 477:K33A15R14S10E10Q03G03T03D02H01 478:S78P09T05F02G01 479:P66L22S05E01T01 480:V43Q20C10K07M06L02S01T01I01

481:A40P33S09D05L03K02Q01H01 482:P87L05F01R01T01 483:E34Q19K17A11G09T02D02

484:D76E08A08T02N01 485:I81L15D01 486:D81S12N04Y01 487:L43I24V23F02T02E02

488:T45S34Q10A04K01 489:P97H01 490:K47Q19A11R08E03L02M01T01

491:E31V16H12I12L08M04P04S02A01N01Y01 492:S53V24N07C04L04T01F01I01 494:F59L21V13I03 495:G46A31F10T05S01L01I01 496:N38T23K22R11S03 497:I65V17L12M01Y01 498:P94I02L01

499:P71R19Q03I01 500:T27N18A11V08P07S07F05E02K02D02I02R01L01 501:Y81F17

502:Q51T25E11K09R01H01 503:L40I28M24V02F02 504:C36S35R13Q11 505:F64L17V13A02I01M01 506:L53V17R08I07Q05M03W01 507:P73A19S05 508:R87T02H02I02A01L01

(ix) N47

4:M97-02 5:D53E25A12S01V01-01G01Y01 6:L45P32A12V03S01-01F01 7:-56L38W02S01 8:-56G39E01V01 9:-69A10M05V04L03T03l01G01 11:-56T20I10A06V02S01 12:T40V23F18A06S02L02G02I01-01

13:V56I20L11T05A01M01 14:V48A18F14I07L07G01-01 16:V57L32G05A01 18:L40V30I20F03T02

19:C64W14S06G04T03V01I01F01 20:L53I19V17M04F01A01 21:S67A18T04V03L02C02

22:C70F10T09S03I02V01 24:L91W02-01M01F01 25:L73I15V04F03M01 26:L70F16S07-01V01

27:L53F24I 13V04S02 28:S66A16F11L02T01 29:L53A11I11V09T07F02S01R01 30:W95R02L01

31:R46K37N12T01 32:Q60K10S08G07R03H03 33:S40R16I15N07G05K03T03V02M02H01 37:-86Y09H03 38:S65H11Y09A03T02R02P01F01 39:G45S14A10Q09K05R05E04T01N01 40:K40R35W12G03S03N01 41:- 98L01 42:G66-13R11E05K01 43:-96G02 44:K80N09R07 45:L82M09Q05E02 47:P98S01

50:T63F13I08A07V03M01 51:P89A05T03S01 52:L89F09 54:I85L05V05F02 55:I63L16V16F02 57:N98S01 58:I53L17V10F06M06A02T01Y01 59:L83F12M02H01 60:Q96L01 61:L53I30V13M01 62:D54N26K10E04G02 63:V28L18P13I12T11F05M03S01A01G01 64:K84W07R02N02S01 65:N57D37H01S01 66:I62L23V07M03F01 67:S44P29A08T03R02D02G02N02C02Q01 68:K66Q12E08A04R01T01L01G01 69:S83T10H01C01A01 70:L65F23I07M01V01 71:T34S31K08Q06R03C03H02E02N01D01G01A01 72:K38N32R09M07E06S02D01 73:L76F19I02 74:S63A34 75:K62E31Q02R01A01 76:V33K15E14R12D06T06A03Q01S01I01 77:Y92F06 79:P96S03 80Λ/94Ι05 81:F91Y07 83:L52V37I09 84:Y81H16 85:L53F40V03I01M01

87:M37S30P09L08T07R02Q01 89:K45Q19R13E07D06N03 90:P67R23K07 91:T47V30I10A06M02 93:V96I02 94:L91V04M02 95:H80Y16C01 97Ύ91Η07 98:E61D16K15N02Q01 99:A77V16I03T01 100:V89I06L03M01 101:K96R03 102:E97Q01 103:A86V12 105:I64V17L14D02 106:D89N04G02Q01 107:H27L21Q21R17Y06N03 108:G64A16K12S04R01 109:E56D29N13 110:E79D11V02I01N01K01 111:F98L01 112:S71A21L04M01 113:G81A10E02D01S01 114:R98K01 115:G89A03S01N01T01V01

116:S34H12N09R09E08D06T03I03K03P02A01Q01V01L01 117:F40L18I16M11S03V03N01

118:P93A01S01F01 119:V37I24L20A09M05 120:F27A21I16L08G08V06S05T01M01N01

121:E40D31Q11K07H02R02S01A01 122:K40R31D05A05E04N03V02L01W01

123:I21A18V15L12T10H09Y05F02M01S01N01 124:N41K11F11T09S07Q04A03R02I01V01L01 125:K44Q18- 13N11R07E01 126:G79D10N03E02 127:L38H10K09T08F07Y06R04Q03S02N01A01 129:I82V12L04 130:I42V40L06A03T02G01F01 131:F85T07S02L01 132:S84N13T02 133:N85H04S03V01Q01

134:G90N07A01 135:E40K26N12P12T02R01S01 136:R35T32K08E05I04V02Q02L01S01G01P01

138:K86L07R04 139:E40Q39D14A01H01 140:T28I23L19M16V10 142:R95H01Q01V01 143:F96L02 144:S68A19T10C01 145:L94V02I02 146:M52T33S08L01N01 147:T78V13I05A01N01 150:N74D20S03 151:F63L13M12Y09 156:R62K25Q09E01 157:S63T16G12N04D01 158:I79N13L03V01

160:D46E37A03S03Q02N02H01 161:R94K01C01 162:I54V45 163:Q97R01 164:E82R11K02Q02

166:A85T07S03I02V01 167:R30Q19H17L11E05C04P02S02K01D01G01 168:C53F25Y14H01W01

169:L97M01 170:V75L21M02 171:E91K03D02Q01G01 172:E62A21R11Q01 173:L83I13F03

174:R70K17N06Q01S01H01 175:K80N11G01E01D01S01 176:T97S01 177:N45K26H11Q10E04R01 178:G53A32E09S01 179:S47Q24R08T06L06K02A01M01 180:P95S01L01 181:C55F39L01 182:D90N09 184:T80S07G05H01Q01 185:F80N05L04S03Y02I01 186:I47L26F10M06V06T01 187:L86I09F01V01 188:G57S20T05A05I03V03F01N01 189:C76H10F03Y02A02G01S01 190:A87V08G01S01T01

191:P74V19T02S01 192:C70S23Y02F02 194:V88I10 196:C82A08S07 197:S84D12 198:I84V14T01

199:I50V28L20 201:Q45G22H15R09N06 202:N43K27D15E05R02H02S01 203:R88H10 204:F86Y10 205:D81E09Q02N02H01K01 207:K40N15E13T09S09D05R02Q01 208:D97N01 209:K40Q33E18P03R01 210:K37T17N15D12E06Q03H01R01S01I01V01 211:F81C05L05G03A01 212:L85Q06V03I01H01

213:T29N26R13A08S06K04Y03D02H01G01 214:L82F07I06M02 215:M59I20L13Q02V01A01

216:E36K17N15S07D05G05H03R03Y02T01A01 217:L33K27Y11N09R07I03M01H01W01T01

218:F40L35M09I07V04 219:N72H09E06D06L01 220:E83N06D03K02 221:N82I10S02D01C01 222:F42V13L11N08I08A04T04S01M01G01 223:K27R26E17Y10Q04H03N02S01T01L01D01

224:I53L31M07Q02V01R01 225:L57Q10M08V07F07I03S02A02 226:S63N26G02T02R01A01Q01

227:S69T26K01A01 228:P71I06H04S04R02L02V01A01G01F01 229:W88Q07G01

230:I43L14G 11T09M07V05A03C02N01 231:Q94E02A01 232:L49V32I 12F02M02 233:Y52C38F02H02A01 234:N87Q05S05 235:N31A15F13M09I07L07S06T05 236:F86W04L03Y02V01I01 237:P83S14A01

238:A20S16T11I 10V07F06K05L05N04D03P02G01 239:L56I 14F10Y09V07 240:I39L30M20-06R01 241:D56H16R07E05K04Y02Q02N02V01 242:Y83H04C02W02F02V01 243:L63F18C08I04M01V01Y01 246:S54P22T06E03I03K03R02N01C01 247:H96Y02 248:N43R18K15H10Q08T01

249:K60T10R05E04Q04A02V02N02I01D01H01 250:L36I21V18F14M06A01

251:F35L27115M07S04A02V01Y01T01 252:K78T04E03A03N03Q01R01S01 253:N82E07R03I01H01D01 254:F26V22I20L04M04Y04S04T04A03H01 255:A30D13E13S12T08N07K02Q02I01V01Y01L01

256:E27Y24K09D07A07F06L04N04W01C01G01H01 257:I29V20L20Q12T05F03M03S01A01C01

258:K68R11D06H02N02E01I01Q01F01 259:S28N15K14A09E08Q08D07H02R01Y01 260:Y50F48

261:I41V27T10L07A06F06 262:L68S13M06A02R02F01T01 263:E86K05A03D02G01 264:K55R20E13I07Q01 265:V52I33A06T05M01 266:K81A05R02M01N01E01Q01T01 267:E79M05K02I02D02A01L01R01T01Q01 269:Q79K04E04L03R03H02 270:E55A19K12Q08D01 271:S79T17 272:L96M02 273:D93N02E02

274:P37I25V14L07M05F02H02A01S01 275:N56S18T13D04A02H01 276:N61C23S11D01 279:R82Q16 281:F85Y08L03V02 282:I84T11V01L01 284:C61Y22A10T01S01 285:F77L12Y08M01 286:L96F01

287:I65S11N08M05V03L02T01 288:K79E13R04Q02 289:M86I03R03L03G01Q01

290:E71Q11K06D02R02G01A01 291:Q58K29E12 292:E90A02D02-01G01 293:K82N07Q03R03-01 294:H53G08Q08D07E06N05Y03K03C01 295:N72S13H04I02K02R01E01

296:Q28P22K15G07E06A06S04D02T01H01L01N01 297:Q39E18H11N08K07D05A02P01S01

298:S69P10L08T05M01 299:E65S06V04K03M03L03G02Q02I01W01D01A01 300:F81Y16

301:T73H09N07D03S02I01 302:M27L26I 18V10T05F04Y02E01 303:E68D19K07G01H01

304:N74S09T07H03G02 305:L84I 12M01V01 306:I26V23A19S09T09L05M03E01K01

307:T21V18I 17A12R10M04N03G02S02F02Y01C01 308:T74S14C05A01L01I01M01

309:V43T19I 13A10G06L03S01 310:S19A19L13F11W10T09V05N04I02G01 311:D91N06E01

312:L83V09M05I01 313:F93L04V01 314:G28F17S13A10I08V08L07T03D01 315:A97G02 317:T94S02I02 318:E84G 11Q01D01 319:T97S02 320:T93V01M01S01L01 321:S96T01 322:T77S09I06L02N01A01V01 324:L84M07I05V02 325:R88K08S01 326:Y84F08H06 327:G76A19S03 328:L95I02F01 330:L69I25V02M01 331:L97I02 332:L63M25Q07H01I01 334:H54Y44F01 335:P96T02 336:E78K08H06D04Q01 337:V61I38 338:T47E22Q13V06A04S03 339:A60E35 341:V67I 13L13A03M02 342:Q70H26R02 343:E86K11

346:D76E15H02N02A01 347:R65H 15C06Q06S03N01 349:I70V28 351:R77P13K03H02Q01

352:H41S24N17D10T02E01 353:R95Q04 354:S67I 12R07K03V02M02L01 355:P97A01

356:C75A11S09R01G01 357:M75V10I 10L01 358:Q54K20A20E01S01 360:R90K08

361:S58L11T08N04G04M03Q03A01I01V01 362:H27Q22R19E09S06K05D04N03C01 363:M96L03 365:Y98F01 366:T77M 19L02 367:D90N04E04 369:V84M09L02T02 370:V62I23L12 373:I81V18 376:Y53F46 377:I92V03L01T01 378:D67N14S09T06A02 379:L86F08I03 380:V42I29L21A03G01 382:T31L20S19N18I04V01F01M01 383:N58S24G 11A03P01 384:L71V24I01M01 385:P94L02V01

386:H93R06 387:A63E15T12S03K01V01 388:V76A17T05 389:T78I08N04A03V03S01

390:C25R25Q24K16H02S02T01 391:D95N04 392:T40I35V22L01

393:K57Q06H05V05M04R04C03P03E02I01S01T01 394:F95L04 395:R93Q03K02 396:N39G20E16D11Q11 397:Y98F01 398:L41V25F19I07T02H01 399:I98L01 402:G90D08

404:T56V11M06N05A04D03S02I02L01E01H01G01Q01 405:I65V30L02 406:L34I29F22M05V04Y02 407:P47T41A04I03V02 408:S51T13L11V05I05M05A01D01C01 410:T51S28D13K01N01Q01 411:S95P03 412:V85L08I04 413:L97M01 414:H62Y24F03R02L01K01 415:D95N02 416:S35D32N13E05K03C03G02R01 417:K79Q14R02T01 418:E96A01Q01 420:P92S03 421:N81D11E02K01H01 422:P98A01

423:E72N06D06K06T02G01H01Q01 424:K34Q13V13E11T09M06I05R03 426:D74N12K12

428:G74E15A03Q02R01H01 432:D69N29 433:E61K20A10D03G02 434:N51S35D03K02G02R01H01 436:N49K21T17S06A03C01 438:K81R17 439:K85Y13 440:S94T04N01 441:D86E07N04 442:Y79F11H07 444:M72K13V07I03L02F01 445:P73A25 448:A70T19I05L02S01 452:I45V26A12M 11S01

454:V48A31L08P07I02 457:G85S08A05 460:R95K01 461:M97V01 463:L83I 12M01V01 465:L90I08 466:F70L19I08V01 467:L85F06I04M01 468:T78A09S07V03 469:T57A18S16N03I01 470:I97V01

473:N61H23K13Q01 475:T52N28K12S03V01H01 477:K97Q01 478:P50S48 479:L57V31P02Q01I01E01 480:V81I06T03G03L01 481:D80E07H04N04P01 482:P82H06L04T02R01 483:K83Q07E03N02R01

484:D77E14N05H01 485:I74L23V01 486:D81N12E03S02 487:T44I34L13V03P01M01

488:T65S19K08I01N01A01 489:P92A03S02N01 490:V39I24L10T09A04E02M02N01K01S01

491:V26A19T13L13S05H04N03F03I02D01Q01E01P01Y01 492:N35S28I 11T10K07V04R01

493:G80S06T06F02A02 494:F51L26T07I07V04M01 495:G36A27V12S07I05L04T03N01

496:S45N28H06K05R05C03T01A01 497:V49I24L13M07A03 498:P97L01 499:P81R10K03Q01H01

500:S24P23F13H09A07L04R03E02V02T02N01K01Y01D01 501:Y87F11 502:Q49K27E20R01

503:L77V10I07F02M02 504:C85S09R03Y01 505:F67V16A07L07 506:I67L18V11T01

508:V43R42L03I03S02A01

(x) N54

1:-98M01 2:-98A01 3:-98L01 4:M95-03 5:E57L24D06A03-02G01M01 6:L42A32P07F04W02T01D01V01G01- 01101 7:-32S30G 14A12T02L02V01 8:G58-33S02W01 9:-33L23A22T12V02M02 10:-88W10

11:S28L28A12F10V08T03I02G02-01W01 12:L25T25V22-12A04S04I03 13:L51V24I 17-01F01G01

14:L51A20F18T02V02-01 15:L82F06V03I02-02M01 16:L54A18V12-05F02G02T01 18:A43L25I 13T08V03- 01F01M01S01 19:C38L37V06F06Y04-02A02 20:L81F05I04V04-01A01 21:S36T26L17V07I03M02-02A01 22:G30C26V18L11I04F01A01-01T01 23:-98L01 24:L60M22F10V02H01 25:L61V25A04I04F02

26:L60I16V06T05A04F03S01 27:L63M21I04V03F03Y01 28:S38L26I 11A09-03M03W02V02T01

29:V36A26L13F06T06-04S02I01E01 30:W52R24P09K04Q02-02S02 31:G31R31K22Q04N02-02A02S01 32:Q33H21R15K11T08-02Y01S01W01 33:R38P30M07T04I04-03K02L02Q01W01A01S01V01 34:-87A06T04 35:-88R09P01 38:K51-12S08N08Q04H03R02Y02T02A01L01 39:A20L16K14- 13S08R07T04G02I02F02V02H01Q01P01 40:R22H18-12G 12W10K07Q03Y03S02L02A01E01

42:G89R03S02E01 44:K41H28R18N05C01 45:L93M04F02 50:T55R25A07W03P01M01H01I01 51:P97A01 52:L88I11 54:F61L34Y01I01 55:L62I33F02 58:L58Y24F06I04V03M01 60:Q96H01 61:L43M28V17I09 62:D34N25R23K11S02E01G01 63:T36R31P13S03I02H02L01V01A01 64:G21E20K19R13D11S06Q02N01T01 65:G32A21Q19E12D05K04N02 66:L43M26T17F04I03V02P01 67:L38Y35F15V03I02R01S01

68:K38N25Q13S11D03L02R01T01 69:S84G11C01T01 70:L48F43I06 71:M45L38Q04T03I02R02E01K01 72:K53R22Q11A05E05 73:L66I22F06M03 74:R42S39Q08G04K02H01 75:E68K21D05Q02

76:K67R23Q03T01H01 77Ύ98Η01 79:P61D31S04 80:V97M01I01 81:F93Y06 83:V70I21L05F02 84Ύ54Η43 85:L80M10F08 87:P75S13T05L02 88:-87W12 89:R91K04Q02S01 90:P58R38Q01 91:V78I15A02C01 92:V94I02L02 93:V66M23I08 94198101 95:C76V11Y06S02W02 96:G97S01

97:H34Y30T21Q04V01P01A01I01 98:E58D27Q08K03 99:A87T07V03 100:V65I29L03 101:K59R33Q06 105:V75G10I08L03 106:D88G10 107:Q81K06H05N02R02 108:A94G04 109:E83D15 110:E53A28D12V01 112:S93G02A01N01 115:G92A03T02 116:E41T23K16M04H02A02Q01D01P01

117:I30Q26L19M11V06F02N01 118:A79P15T01V01 119:T49V20S15I08A02M01L01

120:L26V26F25I14Y02T01M01 121:D55E30N05Q04K02 122:R25P24W21K06Q05G04T03S02A02M02 123:L24I19T17V17N14W01Y01F01S01 124:F87V04S03M01I01T01 125:Q49K28D09N04H02E02R02 126:G90D04E02S01 127:Y63H24F04T02N02 129:V86L06I04 130:A35V28I14F12T04N01G01S01

131:F78L14M01Y01 132:A49S45G02T01 133:N88S06T03 134:G96W02 135:E87D06K03N01

136:R92S03E01C01 137:W72A24S01 138:K74R24 139:Q52A18I10V07T06P01 140:L97M01

142:R86K09H01Q01 144:S80T15A03 145:L56I29M05T04V02 146:T40A37L12S04V01I01 147:T69A11I10V07 148:L69M29F01 149:R92K06 150:D77N19E01S01 151:F86L12 153:M73V23F01 155:K97R01

156:R88K06Q02 157:S57G26E11T02 158:I55V29G11M02 160:E95K01 161:R85L10Q01 163:Q85K10L01 164:E86A10D01 166:A93V03T01 167:Q53G33R05S02A01 168:C43F35Y16H01N01R01 169:L97M01 170:V50L24I21M01 171:E85K04Q04A01D01 172:E56A33M02S02T02 173:L55F38I04 174:R71Q18K05H03 175:K56G22N05E04S03D03A01T01 176:T67S22Y05V01 177:K38Q23R14E10N04H03G02C02 178:G92E05 179:A61K08R07Q04T03G03S03L02E01H01N01 180:P55L19F15Y03N02S01A01 181:I36F27L20V07Q05M01 182:D89E06N03 183:P97L01 184:T78S12I02L02 185:F71L13Y06M01N01I01S01V01 186:F42L34Y16I04P01 187:L64F31I02M01 188:S54H15Q14A10V01N01 189:R40S16C15Q15K05A04H01

190:T37A30I21V05S02M01C01 191:V52T41G02M01 192:S66A30C01 194:V55I44 195:I90V06M01 196:C58S37N02 197:S95T02L01 198:I68V15L14 199:V87I04T03L03 201:G98D01

202:D30E22K13S12L08N06Q02I01R01 204:F96L02 205:D66P09E07S06A03N03G01H01

207:E58K18Q08T05R04D03S01 208:D95N04 209:K53P16E10R08Q06H02T01

210:E52Q30K05R03T02D02C01 211:F98L01 212:L79Q17H01 213:S33R25A15K09T04N03H03E02Q01 214:L85V09M03I01 215:L80V09M07I02 216:R36D24Q13N08H03E03K02G02Y01S01A01

217:M45L36A11I02K01 218:M30I24F24A11L04T02V01 219:N29Y22L19G10F04S02T02Q01H01M01 220:G31E26Q24N03K03S02R02D02 221:S52T26I09V03M02N02F01L01 222:F77L10N03V02W02K01 223:Q22S15I12L10R10A08V05K04T04E01W01 224:L32F27E23G 11103 225:I29M26T23V07L05A03G01 226:S72A25 227:S57T38K01 228:P32F25S22T05L04A03V01I01 229:W41S25T19Y04M04F01L01

230:G46S33A15T03 232:L54V24T08M04F03A02I02 233:Y59F31L04C01Q01 234:E66D24N03F02

235:M60L28I05T02F01V01 236:F73Y20L03I01 237:S57P14Y13H05A01V01W01E01 238:S34G32W06R06D05K03N03C02P01A01 239:V33I28F27L10 240:M50L48 241:K64Q23R06N02D01 242:Y51H37P07F01R01 243:L54F39I04V02 246:P56T14R12A07S03I01 247:H71Q27

248:R27Q26T15N13K06H04S01V01 249:Q57R19K10E05H03 250:I43A23L18V12

251:Y44F27L10S07I02Q01V01T01 252:K53Y10R09N07H05G05S03D01Q01

253:N31E19L19H 12I06D04K02M01 254:L61I 15V06M06Y03T02F01S01

255:Q48E24G08K05S02L02D01A01N01 256:E45G23T10D08K07A01V01 257:L61I25V07M05

258:E27K21N15A13L10R05I02H01 259:D53A21T06E04N03V03K02L01R01S01 260:F87Y12

261:I75V08A06T04M04 262:A41G23V10T09I05E02D01S01L01 263:K28E16Q15R14H 12S10

264:K29R26S24Q12N04 265:V90I06L02 266:E52K28Q12R03 267:K29Q25I 12R11M05H04E04A02L01T01 268:N52H46 269:Q47R30E14K05 270:E34A22R20G08K04S04Q02D01 271:T72S18N04M02L01 272:L91F07 273:D96Q01 274:P83T07A03S02L01C01 275:S45N41Q08 276:S37N25A17G 11F02C01H01 278:-86A12 279:R90Q03K03C01 280:D92N06 281:F81V08L06Y02 282:I88V11 284:S31C28T22A14V01 285:F75Y24 287:I57L39V01 288:R49K34Q09H04 289:M94I04 290:E29Q29D14A10H10Y01R01 291:K46Q28E24 292:E84D14 293:K74E10Q08R02-01 294:S31K21Q15N14D05G03E02H01-01A01 295:N73D22K01 296:P84Q05H03S02 297:N46H22S09D04E03Q03G02A01T01K01L01Y01 298:T68S29 299:E93H02

300:F97L01 301:H38N24Y15T13S02F01D01 302:M25H25L18E07D06Q04T02I02Y01V01F01

303:K70Q13R08E05T01 304:N96T02 305:L93M03I01 306:V50I 18L16E05M04S02T01

307:L42M29I 15H02K02N01Y01 308:T86S10N03 309:T50V30S07A06I03L01 310:L79I07T04V04F02 311:N50S34Y11 312:L97V01 313:F87L12 314:F93I02L01 315:A95G03 317:T96S02 318:E87V06M05 319:T96S02 320:V62T23S11I02 321:S95G03 322:T61S29A07N01 324:L85V06I04M02

325:R90C02K02H01G01L01 326:Y93H03F02 327:G84T06A06S02 328:F76L20I02 329:L97R02 330:L82I07F07 331:L77M21 332:L49M46V01 333:K94R04I01 334Ύ58Η37Ν02 336:E36H29D23Q08 337:V81I 17

338:E41Q24A16T12L02 339:E50A42K04Q01 340:K72R25Q01 341:V74I 17L05M02 342:H58Q27R07Y05 343:E63K27Q03A02 345:I86L12V01 346:D68E09N09T07I01M01 347:R50Q42H02S01 348:V87E12 349:I85L11V02 351:S23R21P19K14A09Q04H03T02 352:H41N40G 11D02Q01S01 353:R91Q05H01 354:Q26L15A13I 11P10S10V06T02H01 356:A25K20S19T10N06G05Q04C03R01M01

357:L42F21V11I09M06Y04S01A01 358:E51D29G08N03S02K01 360:R93H03K02

361:A43S12T12V11M08L02I01N01P01R01G01 362:K69R19Q05N02 363:M87L11 365:Y97F02 366:T95M03 367:D61E34N02Q01 370:I86L12 371:H90C04N02Y01 373:I83A11V02M01 376:F67L24V03C01Y01 377:S25G25A18T13L12I01V01C01 378:D79A11N08 379:L48I27M 13V06F03 380:I40V34L14A07T01 382:M59I21L13V03 383:G87S06N04D01 384:V56L27I10M04 385:P76A21S01 386:H64R35

387:R29T12M10A09N09K09V05I05S04C02L01 388:V82L10I03T02 389:T74I 19N02M01 390:K59R32Q03C02 391:D82T11N02H01 392:T94I04 393:H27K20Q10C08L07E06R03S03T03N01Y01 395:R97Q02

396:G79D16E02N01 397:Y68F29 398:L39T21F15I 15H03V02 399:L66I33 401:K87Q12 402:G75D12N11 403:T93M02L02 404:E68D19N05T04 405:V90I08 406:F58Y35I03 407:P93A02T01L01 408:L39I32M21V05 409:L91I05M02 410:G55S34C04T02N01H01 411:S83T14A01 412:V61A31I02L02S01 413:L95Q02M01 414:H46R24K14T04N04Q01A01 415:D98E01 416:P92S02T01R01

417:K43R11H 10E09Q07T07A02N02S02C01 418:Y40F25H09V09Q05M03K01I01 420:E38S26K13R11A03P02Q02 421:N27K24Q16Y10S06T03D02H02R02C01E01

423:D38E25Q11N07K04R03G02Y01T01 424:D25A23T20E14S04K02V02N01I01C01 426:N70Y14H06D06 428:Q33D25G21E10N02S02K02 429:H79R12N07 433:E44A40D11T01 434:N37K28Q13D10E06S01 436:R29Q26A24N04H03C02K02S01 437:F66L31 438:K87R10Q01 439:K94R02T01

440:N55S25Q07H06P02I01 441:E50D42A02N01P01 442:A95G02 444:V42M27L17I 13 445:P94A05 446:F97Y02 448:I36S22L19T07M06A05V02 450:K98R01 452:I44V21Y18N04F03L03M01A01

454:L72F22V03P01 456:E95D02K01 457:G69A16S11M01 458:L62I26M 10 460:R90K03L02Q01

468:T97A01 469:T64S16A11N05I02 470:I89V04L02M02 471:L86M 12I01 473:N76A10S05R04H01

475:S54R21T09H04C03Q02K02N01 476:L53F25V16I04 477:K33A15R14S10E10Q03G03D02T02H01 478:S78P10T05F02G01 479:P66L22S05E01T01 480:V43Q20C10K07M06L02S01T01I01

481:A40P33S09D05L03K02Q01H01 482:P87L05F02R01T01 483:E34Q19K17A11G09T02D02

484:D77A08E08T02N01 485:I81L15D01 486:D81S11N04Y01 487:L43I24V23F02T02E02

488:T45S34Q10A03K02 489:P97H01 490:K47Q19A10R08E04L02M01T01

491:E31V15H 12I12L08M04P04S02A01N01Y01 492:S53V24N07C04L04T01F01I01 494:F59L21V13I04 495:G46A31F10T05L01S01I01 496:N38T23K22R11S03 497:I66V16L12M02Y01 498:P94I02L01

499:P72R19Q03I01 500:T28N18A11V08P07S07F05E02K02D02I02L01R01 501:Y81F17

502:Q51T25E11K09R01H01 503:L40I29M24V02F02 504:C36S36R13Q11 505:F64L16V12A02I01

506:L53V17R08I07Q05M03W01 507:P73A19S05 508:R87T02H02I02A01L01

(xi) N69

4:M97-01 5:D58E17A14S02V01G01Y01-01 6:L44P32A13V03S02-01 7:-62L31W02S02 8:-63G32E01V01 9:- 78A08V03L03I02T01G01M01 11:-63I 12T10A07V03S01 12:T33V26F21A07L02S02G02I01-01

13:V60I 14L12T05A01M01 14:V54A21I07L06F05G01-01 16:V61L28G06A01 18:L45V26I 19F04T02

19:C59W16S07G05T04V01I01F01 20:L60V17I 13M04F01A01 21:S63A20T04V03L02C02

22:C67F11T10S03I03V01L01 24:L92W02M01F01 25:L70I17V04F03M01S01 26:L72F14S08V01P01 27:L57F18I 14V05S02 28:S71F12A10L02T01 29:L60I 13A09V09F02R01T01 30:W95R02L01 31:K42R39N14T01 32:Q67G08K08H04R04S02 33:S45R16I 11N08G05K03V02H01T01 37:-84Y10H04

38:S62H 12Y10A03T02R02F01 39:G47S16A11K06R05E04Q03T01N01Y01 40:R39K38W14G04N01 41:-97L01 42:G68-15R12K02 43:-96G02 44:K77N10R08 45:L88M10 47:P98S01 50:T69F15A08I02V01M01 52:L93F06 54:I86V05L04F03 55:I66L18V11F03 58:I54L17V10F06M04A02Y01S01 59:L83F11M02H01 60:Q96L01 61:L49I32V15M01F01 62:D60N19K12E04G02 63:V32L19I 14T11P08F05M03A01G01S01 64:K91N02S02R01 65:N54D41H01 66:I69L14V07M04F02 67:S49P22A08T03R03D02G02N02C02Q01

68:K74Q10A04E01R01T01N01 69:S84T11C01A01 70165F25I06 71:T38S34Q07R03C03N02H01K01G01A01 72:K37N36R10M07S02D01 73:L74F22I02 74:S59A38 75:K63E33Q02

76:V37E16R14D07K07T05A04Q01S01I01 77:Y91F07 79:P97S02 80:V96I02 81:F90Y08 83:L58V39

84Ύ84Η13 85:L48F45V03I01M01 87:M42S30L08T08R03P03Q01 89:K50R14Q14D07E05N03 90:P75R22 91:T53V23I 10A06M02F01 93:V96I02 94:L90V05M03 95:H89Y08C01 97Ύ92Η07 98:E65K17D10N03Q01 99:A83V11I01T01P01 100:V88I06L03M01 101:K96R03 102:E97Q02 103:A85V13 105:I62V17L15D02 106:D89N04G01Q01E01 107:H30L21R19Q14Y06N03K01 108:G67K13A12S04R01 109:E62D21N14 110:E85D05V02I02K01N01 111:F97L02 112:S67A24L04M01 113:G79A11E03D01S01 114:R98K01 115:G88A03S01N01T01V01 116:S36H14E09R09D06N05I03K03P02T02A01Q01L01

117:F45I 18M11L10S04V04N01Y01 118:P93S01F01A01 119:V42I27L10A10M05G01

120:F26A23I16G09V07L06S05T02M01N01 121:E42D33Q12H02S02R01K01A01

122:R35K34D06A06E05N03V02L01W01 123:I22A20V17T11H10Y05L04F02S01M01N01

124:N46K12T10S07Q05F03A02R02I01V01L01 125:K45-15N13Q13R07E01 126:G77D11N04E01

127:L43H11K11F08Y07R04Q04N02S01A01M01 129:I80V13L04 130:I46V35L07T03A02G01F01

131:F92S02L02A01 132:S83N14T01 133:N84H05S03V01Q01R01 134:G89N08A01

135:E33K30N14P13T02R01S01 136:R37T28K09E06I05V02L02G01Q01S01 138:K86L08R03Q01

139:E44Q32D15A01H01V01 140:T31I26M18V11L09 142:R94H01Q01V01 143:F96L02 144:S76T11A10C01 145:L94V03I02 146:M58T26S10L01N01 147:T76V14I06A01 150:N80D14S03 151:F59L15M14Y10 156:R69K16Q10E01S01 157:S62T17G12N05D01 158:I78N14L04V01M01 160:D52E31A03S03Q03N02H02 161:R93K02C01Q01 162:V50I48 163:Q97R01 164:E80R13K02Q02 166:A85T05S03I02V02

167:R31Q21L13H12E06C04P03S02K01D01 168:C60Y16F16H02W01L01 170:V72L23M02

171:E90K03D02Q02G01 172:E70A23Q02V01 173:L87I08F03 174:R68K18N07Q01S01H01

175:K90G02E01N01D01 176:T96S01 177:N51K29Q11E04R01 178:G57A36S02E01

179:S53Q25T07L06A01M01K01 180:P95L01S01 181:C62F33T01 182:D96N02 184:T88S05H01Q01A01 185:F90L02Y02S02 186:I53L28M07V07T01 187:L84I10F01V01 188:G64S23A04T03F01N01

189:C85F03Y03A02G02S01 190:A86V08G02S01T01 191:P84V09T03S01 192:C79S14Y02F02 194:V96I03 196:C80A10S07 197:S82D14 198:I83V14T01 199:I54L22V21 201:Q51H17G12R10N06K01

202:N48K30E05D05R03H02S01T01 203:R86H12 204:F85Y12 205:D79E10Q03N02H01K01

207:K45N17T11S10D05E03R02Q01 208:D98N01 209:Q36K34E20P03R02

210:K31T19N15D13E07Q03H02R02I01V01S01 211:F79C06L06G03A01 212:L87Q07I01H01V01

213:N29T22R15A09S06K04Y03D02H02G01 214:L80F08I06M03 215:M67L15I11Q02A01V01

216:E35K19N14S08G05D03H03R03Y02T01A01 217:K31L27Y12N10R08I03M01H01T01V01

218:F45L32M10V05I04 219:N80H10D03E01L01 220:E82N07D03K02 221:N80I11S02D01C01

222:F48V15L12I09A05T04M01S01 223:R28K21E19Y11Q04H03N02S02T01L01 224:I59L23M08Q02R01V01 225:L64M09V08F07I04S03A02 226:S70N23G02T02A01 227:S67T29K01A01

228:P77H05S04R02L01G01A01V01 229:W96G01 230:I48L16G12M08V05A02C02N01T01 231:Q96E02 232:L44V36I13F02M02 233:Y47C43F03H02A01L01 234:N86Q06S05 235:N35A17M10I08L07S07T06F03Y01 236:F86W04L03Y02V01 237:P81S16A01 238:A22S18I10V08F07K06L06N04D04T03P02G01

239:L60I14F11Y10V01 240:I44L33M11-06R01 241:D55H18R08K04Y02Q02E02N01V01

242:Y83H05C03W02V02F01 243:L62F21C09I02M01Y01V01 246:S60P13T07E04I03K03R02N01C01 247:H95Y02 248:N49R20K14H10Q01T01 249:K60T10E05R04Q03A03V03N03I02D01H01

250:L36I22V20F15M02A01 251:F36L29I09M07S04A02V01Y01T01 252:K76T05A03E03N03Q02R01S01 253:N80E08R04I01D01H01V01 254:F27V25I19M05L05Y05S03A02T01H01

255:A34D14S13T09N08E04K02Q02I01V01Y01L01 256:Y27E26D08A08F07L05N04K03W01C01G01H01 257:I31L22V16Q14T05M04S01F01A01C01 258:K77R10E02I01H01Q01F01N01

259:S31N17K13A10E09D08Q03H02Y01 260:Y57F41 261:I44V27L08A07F06T04 262:L69S14M06A02F01R01 263:E86K06A03G01 264:K61R19E14Q02 265:V53I31A06T05M01 266:K88R03E01Q01A01

267:E82M03K02D02I02L01R01Q01 269:Q80E04L04R03H03K02 270:E55A21K09Q09D01 271:S84T11 272:L96M02 273:D93N03E02 274:P31I28V16L07M05F02H02S01A01 275:N61S18T07D05A03H01 276:N69C14S13D01 279:R80Q18 281:F83Y09L03V03 282:I83T13V01L01 284:C68Y25T02S01

285:F74L13Y09M02 286:L97F01Y01 287:I69S12M05V03L02N01T01 288:K77E14R04Q02

289:M85R03L03I02G01Q01 290:E68Q12K06D03R02G01A01 291:Q55K32E11 292:E90A03D02-01 293:K83N08R02-01S01 294:H59Q08D08E06N05Y03G02K01C01-01 295:N69S14H04I02K01R01E01D01 296:Q31P25K17E07A06S02G01T01H01L01N01D01 297:Q42E20N09K08H06D03A03P01S01

298:S67P11L09T05M02R01 299:E66S07M03L03V03G03Q02K02W01I01A01D01 300:F79Y18

301:T72H11N05D04S03I01 302:M30L29I 19F04T04V03Y03C01 303:E67D20K08H01G01 304:N82S08H04G02 305:L83I13V01M01 306:I29V22A21T08L05S03M03E01K01 307:T24V20I 19A14M04N04G02S02F02Y01C01 308:T75S11C06A02L01I01M01 309:V48I 14A11T09G07L04S01C01

310:S21A21F13W12T10L06N04V04I02G01 311:D92N07 312:L81V10M05I01 313:F93L04V01

314:G31F17S14A11I09V07T04D01 315:A97G02 317:T94S02I02 318:E94Q01D01 319:T97S02

320:T94M01V01L01 321:S96T01 322:T83S10I01L01A01 324:L82M08I06V02 325:R89K08S01 326:Y92F06 327:G75A20S04 328:L96F01 330178118V02M01 331:L97I02 332:L67M28Q03I01 334:H60Y39 335:P96T02 336:E77K08H07D04Q01 337Λ/68Ι31 338:T53E20Q14A04S03 339:A67E28 341:V71L14I09A03

342:Q71H25R02 343:E93K04 346:D73E16H02N02A01 347:R70H16Q06C01N01S01 349:I67V31

351:R75P15K03H02Q01 352:H46S23N19D04T02E01 353:R94Q05 354:S64I 14R08K03V02M02L01

355:P97A01 356:C75A13S09 357:M72V12I 12L01 358:Q61K23A12E01R01 360:R89K09

361:S54L13T09N04G04M03Q03A01I01V01 362:H30R21Q13E11S06K05D04N03C02 363:M95L03

366:T74M21L02 367:D89N05E04 369:V82M 11L03T02 370:V64I20L13 373:I79V20 376:Y57F41

377:I93V03T01 378:D67N 14S10T06A01 379:L94I03F01 380:V45I32L16A02G01 381:P98S01

382:T34S21N21L13I03V01M01 383:N56S27G09A03P01 384:L79V16I01M01 385:P93L03V01 386:H94R05 387:A62E16T11S03K01V01M01 388:V73A19T06 389:T84N04A03V03I01S01 390:C29Q27R23K11H02S02T02 391:D94N04 392:I39T36V22L01 393:K56Q07V05M05R04C03H03P03E03I02S01T01 394:F97L02

395:R94Q04 396:N44G22E17Q09D05 397:Y98F01 398:L46V26F13I08T03H01 399:I98L01 402:G98D01 404:T59V12N05A05D04S02I01E01H01G01Q01 405:I61V34L03 406:L38I32F14M05V05Y02

407:T46P41A04I04V02 408:S57T14L12I06V04C01D01 410:T54S28D14 411:S97P02 412:V86L09I02 413:L98M01 414:H62Y25F04R02L02N01 415:D96N02 416:D36S28N14E05K03C03G03R01

417:K78Q16T01N01 418:E95A01Q01 420:P92S04 421:N79D13E03H01K01 422:P98A01

423:E70N07D06K06T02G01H01Q01 424:K30V15E12Q11T10M07I06R04 426:D75K13N10

428:G71E16A03Q02R02H01 432:D74N24 433:E65K22A03D03G03 434:N45S39D03K03G02R01H01 436:N56K23T11S07C01 438:K80R19 439:K83Y14 440:S93T05N01 441:D84E08N05 442:Y79F10H07 444:M70K14V07I03L02F01 445:P69A28 448:A68T20I06L03S01 452:I40V29A13M 12S02

454:V52A27L08P08I02 457:G83S09A05 460:R95K01Q01 461:M97V01 463:L85I 10M01V01 465:L97I01 466:F70L20I07V01 467:L83F07I05M01T01 468:T76A10S08V03 469:T63A15S14N03I01 470:I96V01 473:N56H26K15Q01 475:T46N31K13S03V01H01 477:K96Q01E01 478:S53P45A01

479:L63V25P03Q02E01I01 480:V81I05T04G03L01D01 481:D79E07H05N04P01 482:P89L04T03

483:K81Q08E04N02R01 484:D75E16N05H01 485:I71L26V01 486:D79N13E03S02

487:T49I26L14V03P01M01 488:T70S13K09N01A01I01 489:P91A03S02N01

490:V42I25T10L05A04M02N01K01E01S01 491:V24A21L14T12S05H04N03F03D01Q01E01Y01

492:N39S24I 12K08T07V04R01 493:G90S03T02A02 494:F57L21T08I08V01M01

495:G40A23V11S06I05L04T03N02F01 496:S50N21H06K06R06C03T02A01 497:V55I25L14M01A01 498:P97L01 499:P91R03H01Q01 500:S25P17F15H10A07L05R04E02V02T02N02K01Y01 501:Y86F12 502:Q52K30E14R01 503:L82I08V03F02M02 504:C92S03R02 505:F67V15A08L07 506:I74L13V09T01 508:V48R35L04I03S02A01H01

(xii) N70

1:-96M03 2:-96A03 3:-96L03 4:M92-07 5:E88D07-03 6:L51P29A07F05-03V01 7:L91S04-03 8:G92-03E01S01 9:M39A28T16V10L03 10:-98W01 11:T96P02 12:T92S03A02 13:I62V23L09G02H01 14:F85L08I04

16:L61V31A03M01 17:-97L02 18:V64I27L05 19:C96L03 20:I71V22L03F01 21:S96A01 22:C94L02 23:-95L04 24:L88-11 25:L93F05 26:L57F31-09 27:F68L26I03 28:A57S31F03L03T02 29:T54A29S05V05L03 30:W95R03 31:R96-01K01 32:S58K33R03M02N01 33:I46R18T18M10V04 36:-96G03 37:-97K02 38:S84P09R03 39:Q57G26R11S02 40:K56S25R09T05N03 41:-93L06 42:G49E45R02-01 43:-93G06 44:K94R04

45:Q42L35E19 50:I51V22T16M03L02A01F01 51:A42T30P15S07R02 52:L59F36I03 54:I78L18V02

55:V56I33L07A02 57:N91S08 58:I42L16M 15T11V09A03 59:L87F12 60:Q96H03 61:L87I 11

62:N82R07D05S02 63:P53T19L11K04E03I02M02 64:W57K27R12 65:N80S07D04A03K02E01 66:L92P03M02 67:P85A03S03M02F01Y01 68:E58Q23K08L04D02G02 69:S80H15T02 70:L64I 18M06F04V04Y01

71:K60E11H10D08M04R03 72:K50E46M01 73:L96I03 75:K50E23A11R11M01Q01 76:K85T12 79:P90S09 80:V77I21 83:I76V21L02 84:Y53H38S03W01 85:L92F03M02V01 87:P61S33T02L01Q01 88:-96W03 89:Q65E23K03R03L02 90:K63R30P04 91:V88I07A03 93:V97I02 95:Y80H11C07 97:Y88H03Q03R02 98:D61E38 99:V52A32I 14 100:V96L02 102:E98D01 105:I79V20 106:D84G 11N03 107:Q73L15H06N02R01 108:A51G47 109:D84E15 110:D50E38N07A02T01 113:G92A03R03 115:G96A02

116:N41T16S14K07I04R04V03A03E01 117:L75M 18I05 118:P95A04 119:L91I03V03 120:F39L31I21A06 121:K48E23D15R07Q03 122:K87R07V02T01 123:L68I 16A07M03F01V01 124:F68A12T11S04I01N01 125:Q57K34R03E02 126:G93E03 127:T73S11Y04R03A02P02L01 129:I96L01V01 130:V80I07A06L03G02 131:T63F29I03V02 132:S89T07A02 133:N96-01S01 136:T62R21Q07P03M02 138:K89R10 139:Q96K02E01 144:A84T07S03V02I01 145:L96I01V01 146:T95M03 147:T91N07 150:D72N27 155:K97R02 156:K94R05 157:S80G 12T07 158:I95V03 160:E88A03D02K02M02 161:R98-01 163:Q98L01 166:A81T18

167:H57R23N07Q06C02G02 168:F93Y06 169:L96M03 170:V97L01 171:E96Q02D01 172:R93E03A02 173:I47L47F04 174:R82K13S03 175:N88K04E02S02 177:H86K05N02Q02C01 178:E69G27A01

179:R65Q21K11 180:P97S02 181:F88L11 182:N57D42 184:G47T24S20R03N02

185:N40L18S13I 11F06K03G01V01 186:F81L11P03C03 188:V32I29T22A06S06N01 189:H92C06

190:A89V07S02 191:V96F03 192:S97A02 194:I69V30 198:I90V08 199:V80I 19 202:D92E03Q02 205:D98E01 207:E96D01 208:D96E03 209:K85Q08E05 210:K83N08S04Q02 212:L73V19I03R02 213:T91D03S02A01 214:L98F01 215:I90L05V03 216:E42N26D20S03K02Q02 217:L82W10I04M02 218:L53I37T03M02V02 219:E49D31N08L07Q01V01 220:E95D02 221:N92T03I01Y01 222:N74G 11F06S03D01

223:K69R13E04W03D03N01S01 224:L88V04F03Y03 225:Q85V04F03L03M01

226:N49S15R14Q08G03I02T02L01 227:S92D03R02A01 228:I54P26V07L04F03A01 229:Q61W28L07H01 230:T68G10A07I07V05 231:Q80A13V03 232:L92V02-01I01M01 233Ύ96-01 234:N95S03 235:F94I03V01 236:F92I03L03 238:T77I06N04S04A03R03 239:V53L30I 12F03 240:M96L03 241:D67E26N02S02

242:Y80H07F06R03 243:L73I21V03M01 248:Q63K21H13 249:K64Q10R10T07G03E01

250:M40L36I 16V03A02 251:I60F28L05M03V01 252:K88E07A02 253:N93L02I01S01

254:I26T24F23A07S07V07 255:E83D04G03L03Q03 256:K60E29N03T03A02 257:V55F23I 11L08

258:D56R22N08K07H03 259:Q43K24D08R08S07N02E01I01 261:T50V27I20A01

262:L57T13S10G05R05A03Q03 263:E84D15 264:I64R34Q01 265:V53I46 266:A41K21N12M 10T06E03I01 267:E53M25A07T04I02R02K01 269:Q73K24R01 270:E56K32A05L02 271:T62S37 272:L94F02W02 274:P89L04A03R01 275:T59N23S16 276:C93S06 278:-96A03 281:F96Y03 282:I96V03 284:A89C06S02V01 286:L92I06 287:N61I37 289:M90I07V01 290:E90Q05D01K01 291:Q79E20 292:E97G02 293:K73Q21R03 294:G55K15Q15E07R03 295:N96K03 296:G51S21D09P06V03A03I02H01 297:H50Q19D19N04Y02K01 298:S92T03-03 299:E63K13V07D05-03I03N01 301:T72N23H03 302:V59T17I07E07M04Y02 303:E82D11G04 304:T62S20N15 305:L96M03 306:S51V29T11L06 307:R84M06Q03G03 308:T68S30 309:T96V02

310:L76V16I04F01 311:D81E10N04G03 314:L59F26V11I02 315:A96G03 318:G92E07 319:T97S02 320:T88S08V02 322:I37T37N07V07L05H02 323:T96A02 324:L97M02 325:R79K09Y04C02D02

326:H46Y29F23 327:G85A11S02 328:L80I 14F03V02 329:L94V03 330:I84V09L03T02 332:Q46L38H13M01 334:Y86F07H05 336:E88D06H03 337:I96V02 338:V52E35Q07A02T01 339:E95A03 341:I46V37M 16 342:Q63H36 343:K65E29Q04 347:C40R35S18H03 349:I96V03 351:R94Q05 352:D60S24N10E03

354:S96Q02R01 356:C73R12S08A03G02 358:A80S09E05V03 361:S92G03A03 362:Q91K05R03 363:M96L02 365:Y89F10 370:I50V46L03 373:I94V03 376:F82Y15 377:I79L09V07M02 378:D72N11A06T05S03

379:F63L29I07 380:L57V30A06I05 382:L71I 10M07F07 383:N67G26S06 384:V80L11I04F02 386:H88R11 387:A70T23S03M02 389:I57T38A02 390:K53R45 392:T73V23I03 393:K64H24R07E01Q01 394:F76L22I01 395:R84K15 396:D57Q26G09E03N01 398:F61V18L07I05T05M01 400:P95S03 402:D67G30

404:M52T34L06I04V01 405:I93V06 406:F87I07L03-01 407:P93-04 408:M46V15A12L08T05-04S03D02 409:L95-04 410:S34T26K15Q08-04R04N03 411:S80P15-04 412:V75l l8-04 413:L95-04 414:H65Y21- 04Q03K02 415:D95-04 416:S83P05N04C02-01R01 417:K82R17 418:E94Q05 419:F97W02 420:P93K05 421:N95K04 423:E96Q01 424:K62Q30T03E02 426:D64N34 428:G96E03 432:N64D35 433:A59E32K03P02 434:N97D02 436:T61A26S08D02 438:K95R04 439:K96R03 440:S94N05 442:Y73F16A05H03

444:M93V03I02 448:A84T12I01 452:I82M08V07 454:A64V19L12I03 463:L69I30 465:I60L38V01

466:F73I 16L04V03 467:L92F05 468:T97I01 469:A42S29T15M05V04I02 470:I96L03 473:N95K03

475:T93S03N01 476:L96F03 477:K96R02 478:P90S09 479:V73L16T03I03A01 480:V84I08K03E02

481:D91E07 482:H55P33R09L01 483:K92E05 484:D89N04E03 485:I96V03 487:I91L04T03 488:S61T33I02 489:P96S03 490:L45I20V15E11A03F01 491:V49I21T18P07S03 492:S63T30C02-01 493:T37S31F19G06L02A01 494:L64V23F06M03A01 495:A56V15S13G 11I01L01 496:N93S03L02

497:M53A19I11V05L03H02 499:R70K25Q03 500:P72S15D05H05 501:Y96F03 502:E65Q29R02A01 503:V62L34I01 504:S61C26R06G02Y02 505:F69V25A03 506:L61V26I 11 507:P92Y03C03

(xiii) N77

1:-92M07 2:-90A07M01 3:-90L09 4:M98A01 5:D85E11L01S01 6:S59G 17L17A02N01T01W01 7:-93S06 8:- 94G02S02 9:-94V03A01 10:-97W02 11:V40I 18T15L10M07S02A01F01R01 12:S80T07N05G02V02L01 13:T80L10A02M02I01P01V01 14:A80I05L05T03V02G01P01 15:I77L13V06A01F01 16:L88V09F02 17:-96L03 18:L93F03A02 19:L86G07A02C02 20:L84I 11A01C01F01 21:L89S07A01T01 22:A82G05C03L03F01I01T01 23:-93L06 24:L81V10F03I03 25:V46I 19L18T13A01S01 26:C64L10S10Y07F02V02I01 27:L96F01M01V01 28:F59L19S13A03M01V01Y01 29:L93A02V02S01 30:T71W10I09A02M02Q01R01V01

31:L51R22F13M03I01K01N01Q01S01T01W01 32:S55G 10K10T10N06H02A01R01V01

33:S78R07A03G02P02-01L01W01 34:-94A03S01 35:-97K02 36:-89G 10 37:-92K06H01

38:R77W10K09N01S01 39:G64R14D10S03T03L01Q01 40:K85R11E01H01 41:-93L06 42:G89S06-01A01E01 43:-93G06 44:R61Q26K07H02T01 46:P98S01 50:R60K23T11A02M01 51:P98A01 52:L98F01 53:P98S01 54:L63F18I 17V01 55:L94F01I01M01V01 58:L97Y02 60:Q94-02H01L01 61:L93F02I02M01

62:R80D11N03C01H01S01 63:S85T13R01 64:Q78K11R07E01 65:D80A05E05N05Q02G01 66:M68L26P05 67:L86Y05V03F02M01 68:T81K11S03N02 69:S98L01 70:L90F06Y02 71:T84M 14L01 72:K97E01R01 73:L97F01V01 74:S96T02R01 75:K85E10Q03 76:E67K28D01R01V01 77:Y98F01 79:S78P14A03C01D01 80:V94M05 81:Y72F26S01 83:V98L01 84:H60Y36W02 87:P81S15T02 88:-92W07 89:R85Q10K02G01 90:R78P18Q02 92:V96I03 93:V98M01 95:S85C14 96:G98R01 97:Y96C01F01V01 98:Q81E15D02 99:A73T26 100:V98I01 101:K97R01T01 102:E97D02 106:D96N03 107:Q76K14H09 108:G81A15D01R01

109:E92D06K01 110:E84D13A01S01 114:R98Q01 115:G96A03 116:D60S14E11A06K03H02

117:Y85I06M05Q01V01 118:P96A03 119:V88A03I01L01M01N01S01T01 120:F89L09V01

121:F72Y07L06D05Q05N01S01 122:N81R10D01H01K01P01S01W01 123:F90I07L01 124:T94F03N01 125:K96R03 127:N88Y09D01S01 128:G98T01 129:I86L07V05 130:A88V10I01 131:F96V03 132:S97A01G01 133:N93D03S02 134:G97D01W01 135:E60D36N02 136:R97K02 137:W98A01 138:K97Q01R01

139:V63A23Q09I03 140:L98F01 141:R98K01 142:R89K09Q01 143:F96Y02W01 144:S94T03A01

145:V61L21I14E01M01 146:Q86T11H01 147:I81T17A01 148:L98M01 149:R97H02 150:N96D03

151:F96L02I01 152:G98R01 153:M97V02 154:G98R01 155:K94N05 156:R94K03Q01 157:S97G01T01 158:I93F01L01M01N01V01 159:E98D01 160:E96K01N01Q01 161:R92Q06L01 163:L81Q15I01M01 164:E96G01K01Q01 166:G72A17S05V02E01I01 167:S64R13Q11G03A01D01H01N01T01 168:F88Y06C05 170:L80V11I05M02 171:A46E46Q03D01T01V01 172:E80V13A05S01 173:L88F10C01 174:R88S05Q03K02 175:K92E03N02G01 176:T96M01N01S01 177:E77K11D05Q03H01 178:G98A01 179:E50K36Q06A05S01 180:P98L01 181:F96L02S01 182:D86N10I01S01 184:T68V14K09L05-02 185:F96L01S01Y01

186:V68I10L10M07F01T01 187:L97I01V01 188:S98R01 189:R92C06L01 190:S88A10T01 191:V98L01 192:S97C02 194:I89V10 195:I98V01 197:S98A01 198:V92I07 199:L39I35V25 202:S82E06Q03K02R02T01 205:D90H06E01N01 207:D73E23H01S01 208:D97-02 209:E78K13D05-02 210:R86K06Q03-02 211:L86F10- 02 212:L96-02H01 213:T94N02A01K01 214:I86L13 215:I84L10V02S01T01 216:R52H25N11Q03S03K01T01 217:L76F15I05P01V01 218:I97L01M01 219:N98S01 220:D81E18 221:N89I02T02Y02K01S01 222:F98L01 223:Q86R05K03S02E01 224:I90L05F03 225:M93V03I01L01 226:S98N01 227:S89G06T02C01

228:P94A01H01R01S01 230:G98S01 231:E89Q09K01 232:L48M43F02W02I01R01 234:N94H02D01T01 235:I90L07V01 238:S80G07N05R05A01 239:L94I02V02 240:L89M 10 241:D92N03E01H01Q01

242:W90H07C01 243:V68L25I05M01 246:P97L01S01 248:R69Q18H10K01 249:R88K07C01H01S01 250:L73I15M09V01 252:Q68R18K06A03E01H01 254:F68Y25V05L01 255:G77E10R06K03A01

256:R48C17G 14K10S03N02H01L01 257:M67L18V14 258:K96R03 259:D82E07A05H01S01T01

260:L88F10I01 262:A89R03S02D01F01T01 263:R64H13E10C03G03L01N01V01 264:S81I07R07Q02 265:V94I05 266:R80H06K06C02E02Q01 267:E46D43R06M03 270:A67D18E11I01T01 271:S82T15N01 272:L94F02I02 274:P98S01 275:N71S17D05R03E01T01 276:S97C02 277:P98L01 278:-92A07

279:R97Q01S01 281:F93Y05V01 283:D98H01 284:C97Y02 285:F97-02 287:T72I 14N09S02A01 289:M90I09 290:A85E10T02V01 291:Q92E07 292:E98K01 293:K93Q03A01H01 294:Q84K11E03 295:D89N09S01 296:P98L01 297:L72H11N07Q03D01F01M01 298:S98T01 299:H90E07Y01 301:H57Y11Q10N09F07C02 302:M92L03Y03 303:D84E14N01 304:T92N07 306:L85V13E01 307:M96I01K01T01 309:T96V03

310:H89L05F03Q01 311:N98I01 313:L82F10I06 315:G89A09S01 316:G98S01 317:T97L01S01

318:E97K01Q01 319:T98P01 320:V86T10I01L01 321:G82S15V01 322:T97I02 324:L96M03

325:R96H01L01T01 326:H82Y15F01 327:A76T09S07G06 328:F94L05 329:L98Q01 330:V59I25A10L03T01 332:M88L07Q02T01 334:Y98F01 335:P98Q01 336:K75E17H05Q02 337:V86I 13 339:A84E09V05N01 340:R85K10G01H01S01 341:V96I03 342:Q92H07 343:E93K02Q02A01 347:R88S05C02L02H01

349:V88I10L01 350:G98R01 351:R97H02 352:A61S21N06D03E02G01Q01T01 353:R98W01

354:L71S11M 10R05Q01 355:P97A02 356:A38T30S26-02C01L01 357:L78M09V07-02P01 358:E80D13- 02K02G01 359:D97-02 361:A71V09S07P03T03K02G01 362:A71S13K06N03R03T01 363:M98L01 364:P98H01 367:D98N01 369:V98M01 372:E97-02 373:V88I10A01 375:R98C01 377:A89I06L03

379:V56I40L02 380:I86V07-02L01M01 382:M98L01 383:N84S10G05 384:L97F01Y01 387:R88A06M03H01 388:V97I01L01 389:T64I34S01 390:R94Q05 393:A56P11N07H06D03V03E02Q02T02L01 395:R97H01Q01 397:F89Y10 398:L88T09Q01V01 399:L57I42 401:K97E01R01 402:G94D03S01 404:D88T06N03E01 405:V77I22 406:I96F03 407:T89P10 408:L98V01 410:N88S11 411:T88S10A01 413:H90L09

414:Y81H14Q02S01 416:P89S10 417:S75D09K07T05E01N01 418:Q98L01 419:F96W03

420:L65K23V03Q02M01P01R01 421:T71K15N10A01M01 423:Q76E10K03R03H02N01W01

424:E78K09A05T05D01 428:E86G07D02A01N01 432:D98V01 433:A76E11D09S01V01 434:N90K05S03 435:Q73G 10R09E02H01K01M01 436:S92C03A01E01T01 438:K98T01 440:S80N19 441:P88D10S01 443:F98Y01 450:R84K10S02H01P01 452:L81M06I05Q03V02 454:L97M01V01 456:E98Q01

457:S71P17G 10A01 459:A98R01 460:R98S01 461:M97G01K01 462:E98A01 463198F01 465194105 466:Y73F26 467:L82F17 468:T94A02S02 469:A71S14T13G01 470:I93L05T01 473:S55N35K03-02R01T01 475:S59T39L01 476:L94F05 477:Q81H05K05R05E02 478:P98S01 479:L97Q01T01 480:G67V25E05A01C01 481:A75D11E09K02S01 484:D84E11S02N01 485:I98A01 486:D98N01 487:L97I02 488:T98S01

490:L82E05I05A02Q02R01 491:S85V09G02C01T01 492:S96T02P01 494:L90F07P01 495:G97C01N01 496:N94K03H01 497:L73V13I07M05 499:R98G01 500:P96S03 501:F86Y13 502:Q90E09 503:L82M 15V01 504:C77R18S02T01 505:L60V17M11A06I02F01 506:R75I06V06S05L02C01H01Q01

507:A55P19T07I03E02L02M02K01Q01S01V01 508:R98C01

(xiv) N81

1:-71M28 2:-78A21 3:-78L21 4:M92-07 5:E50D46M03 6:L50F35I10S03 7:S57L28-03G03N03P03 8:G75S14- 10 9:A42T28-10V10I03P03 10:-92W07 11:T39L28V17F07I03S03 12:T46S39A10V03 13:L60I28V07G03 14:L60I17V17F03 15:L96I03 16:V64A25L07F03 17:-89L10 18:I42L25M25F03V03 19:C64L21A10F03 20:L53V35I07A03 21:S75F07M07L03T03V03 22:C50F17Y17L14 23:-71L28 24:L96M03 25:L96S03

26:L71F10N10I03M03 27:L82T10F03M03 28:S53L14I10-07N07H03W03 29:T25A17L14F10Q10S10-07W03 30:W60-14S10V10K03 31:R67I10S10K07A03 32:K67Q21R07N03 33:R42K32M17-03L03 34:-89A07S03 35:- 92K07 36:-78G21 37:-89K10 38:K42Q28R28 39:R35G28-21T07D03H03 40:R60W17K10Y07F03 41:-82L17 42:G82S07-03R03T03 43:-82G17 44:R50A17K10H07N07L03T03 45:L82M17 50:T67P17A07S03V03 52:L85I14 54:F50L46Y03 55:L78I21 58:L53M32F10I03 59:L92H07 60:Q96R03 61:V60L32I07

62:D46E25K25R03 63:V25T21L17G 10R10I07A03P03 64:K75R17E03N03 65:E60D25A14

66:L53M17P14V10F03 67:I35L21F17R17Y07 68:K92P03Q03 69:S96A03 70:L85F07Y07

71:M53R28L10D03V03 72:K75E21D03 73:L85I10F03 74:S92G03K03 75:E60K32Q07 76:K53T35R10 77Ύ96Η03 79:P96S03 80:V57M28I14 81:Y64F35 83:F42V35I10L10 84:Y50H42W07 85:L96F03

87:S75M10P10A03 88:-71W28 89:R64Q25E10 90:P89R10 91:V50C35T14 92:V96I03 93:V96I03 95:C64S35 96:G89S07N03 97:Y89F07C03 98:Q46E28K14D10 99:A46V35I14T03 100:V57L42 102:E92D07

105:I50V28L10N10 106:D92N07 107:K32Q32H21N10R03 108:A71G28 109:E92D07 110:E78A10D03T03V03 112:S89G 10 113:G85A10S03 115:G89A10 116:D35E35A14H07K03Y03 117:F42M32I14Q10 118:P85A14 119:A42V32L14T10 120:V46L39F10A03 121:Q57D35E07 122:M42R32K10T10H03 123:I53W39M03Y03 124:S57T21A10F07L03 125:K57H25Q10N07 127:Y46N39H10D03 129:I64V28L07 130:V82A10I03T03 131:Y42F32A10V10G03 132:S57G42 133:N57T42 136:R96C03 137:W89A10 138:K57R42 144:A50S39T10 145:I53L46 146:T85I07M03S03 148164F35 149:R57K42 150:N96S03 153:M89V10 157:S85G10T03 158:I78M17L03 160:E96K03 162:I96V03 163:Q57K39R03 166:A96T03 167:Q75H17R03T03

168:Y50F32C14I03 170:V67I10L10A07T03 171:E35A28S14Q10K07N03 172:E78A21 173:F85L14

174:R64S14H10K10 175:K53N21E10G10Y03 176:T92A03S03 177:E42K42Q10N03

179:K50Q21A14E07L03M03 181:F89V10 185:F96Y03 186:F53L25Y14C03G03 187:L85F14 188:S96G03 189:C71R14K10S03 190:A96T03 191:G50V50 194:I57V42 196:C96S03 197:S57T42 198:L50I42V07 202:E50D39Q10 205:E53D46 207:E46T46N03R03 208:D96N03 209:K50E21Q17H03P03T03 210:K64E17Q17 211:F96Y03 213:T75R10F03M03N03S03 215:L96M03 216:N64D17G07H03K03Y03 217:L75I14F03M03N03 218:I89L10 219:N96T03 220:S39E35Q10N07K03R03 221:N46T25I07S07V07Y07 222:W50F46L03

223:R46K42S07H03 224:L71F17G10 225:M75V17F03T03 226:S92A03N03 227:S96T03 228:T57P28V10A03 231:Q96V03 232:L92M03V03 233:L53Y42F03 234:F60N39 235:T53I39V07 237:P96D03 238:K67S17R10N03 239:I75L14V10 241:R53D25G 10C03K03Q03 242:H82K10L03W03 243:L39V32I28 248:R50H32N10K03Q03 249:K46Q42T07M03 250:I96A03 251:Y53F42M03 252:K82A10Q03T03 253:N85S10H03 254:Y53V25F17L03 255:L53E28D07V07N03 256:K85S07D03V03 257:L96I03 258:A50K35Q07G03H03 259:E35A32D28K03 261:V60I39 262:G46A28R10M07K03Q03 263:E82Q10K07 264:R67Q32 265:L53V35I10 266:K64E17N10R07 267:M82R10E03L03 268:H64N32S03 269:K60Q35R03 270:E89Q10 271:T71L25I03 274:P96I03 275:N89S10 276:S57N42 278:-71A28 279:R96Q03 280:D96H03 281:F85Y14 282:I96L03 289:I50M46L03 290:Q67E32 291:Q89E10 293:K96Q03 294:Q32H25N21D10K07E03 295:N89V10 297:N75D10Q10H03 298:T53S46 299:H50E46Y03 301:N57H39T03 302:M39D25E21Y14 303:E82D07Q07L03 304:T53N35G 10

305:M53L35A10 306:S46V39L10I03 307:K57M28N10G03 308:T96S03 309:T85V10A03 310:V53L28F17 311:N89D10 312:L92M03V03 314:F89G 10 320:V78T21 321:S96G03 322:S53T46 325:R92K07 327:G89S10 328:L71F25I03 329:L53R46 330:I89V10 332:L92Q07 333:K53R46 334:H67Y28W03 336:E71H17D10 337:I57V42 338:E64Q35 339:E96G03 340:K85R14 341:L46V39I 14 342:H78Q21 343:E71K17Q07G03 347:R82S10D03K03 348:V96I03 351:R53P42V03 352:N60H25D10Q03 353:R96Q03 354:S85A10C03 356:C67A14S14K03 357:M85I14 358:E96D03 361:S78A17I03 362:R71K25Q03 367:D96E03 371:H96Y03 374:Q96L03 376:F96Y03 377:A53S14I 10L10T07V03 379:I92L07 380:V78I21 382:M96T03 383:G82S17 384:V53L42I03 387:T60A17K10M 10 388:V92A03L03 390:R96Q03 392:I64T35 393:Q35E32H25D03T03 395:R89Q10 397Ύ96Η03 398:T82S10F03R03 399:I50L50 402:G53D46 403:L50T46M03 404:N67T28D03 405:I53V46 406:I60F25Y10M03 407:P96A03 408:L89M 10 409:L96I03 410:C53S42T03 411:T60S39 412:V46S28A25 413:Q53L46 414:H42A25F17Y07K03S03 416:P96V03 417:T50K42E03S03 418:Q92K03V03 419:F89W10 420:K96Q03 421:N89Y10 423:E35N25T25D07A03Y03 424:A32C25T21S10E03I03N03 426:D53N46 428:G46S25E14T10A03 429:H96R03 431:L89I07V03 433:E96K03 435:G96M03

436:R57S25K10D03I03 437:F96L03 438:K64R32C03 439:K71R28 440:N96S03 441:D92E03Q03 442:A85G 14 445:A53P46 448:A89S10 452:V46I35M 17 454:L82V14P03 457:G67S28N03 460:R46L39Q07N03V03 463:L96I03 465:I50L50 467:L50F39I10 468:T96S03 469:T67A25N03S03 470:I78L17V03 473:N82K14S03 474:F96Y03 475:T71K21N03Q03 476:L85F14 477:K50R42I03S03 478:P50T25S17A03R03 479:L75P21T03 480:V60M28E10 481:D67A25P03S03 482:P85T10S03 483:E39A28K21D03R03V03 484:E50D46N03 485:I85L14 487:I71L25V03 490:E89A07H03 491:S53V32L10I03 492:S89T10 493:G96S03 494:L53F42S03 496:N53S42H03 497:I78M 14L03V03 499:R96C03 500:P85S10E03 502:Q78K21 503:L50F46M03

505:L71A14F10V03 506:L50I35V14

(xv) N82

1:-98M01 2:-98A01 3:-98L01 4:M96-03 5:E58L25D05A03-02G01M01 6:L43A33P07F02W02T01D01V01G01- 01 7:-34S29G15A12T02V01L01 8:G57-34S01W01 9:-34L24A21TllV03M02 10:-87W11

11:S29L28A12F10V07T03I02G02-01W01 12:L26T24V23-12A04I03S03 13:L51V25I 17-01F01G01

14:L51A21F18T03-01V01 15:L82F06V03I02-02M01 16:L55A17V11-05F02G02T01 18:A44L26I 11T09V03- 01F01S01 19:L38C37V07F06Y04-02A01 20:L83F05I04V02-01 21:S35T27L17V07I03M02-02A01

22:G31C25V19L12I04A01-01T01 24:L59M22F10V02H01 25:L60V25A04I04F02 26:L60I 16V07T05A04F02S01 27:L62M22I04V03F03Y01 28:S38L26I 11A09-03M03W02V02T01 29:V37A26L14F05T05-04S01I01E01 30:W52R25P09K04Q03-01S01 31:G32R30K22Q04N02-02A01S01 32:Q34H22R16K10T08-02Y01S01W01 33:R38P31M06T04I04-03L02K01Q01W01A01S01V01 34:-87A06T04 35:-87R09P01 38:K51- 12S09N08H03Q03R02Y02T02A01L01 39:A20L16K14-12S09R06T03I02F02V02Q01H01G01P01 40:R22H19- 12G 12W09K07Q03S03Y02L02A01E01 42:G89R03S02E01 44:K42H29R17N05C01 45:L93M03F02

50:T55R26A07W03M01H01I01 51:P96A01 52:L88I 11 54:F60L34I01Y01 55:L62I34F02 58:L59Y25F06I04V03 60:Q96H01 61:L44M29V15I10 62:D34N26R23K10S02G01 63:T37R32P14S03I02H02A01

64:G22E20K18R13D11S06Q02N01T01 65:G33A21Q19E10D04K04N02 66:L43M26T17F04I03V02P01 67:L38Y36F15V03S01 68:K36N26Q14S12D03L02R01T01 69:S84G11C01T01 70:L47F45I06

71:M45L38Q04T03I03E01K01 72:K53R23Q11A05E04 73:L66I23F06M03 74:R44S37Q08G03K02H01 75:E68K21D05Q02 76:K68R23Q03H01 77Ύ98Η01 79:P60D32S04 81:F95Y03 83:V72I21L05 84Ύ55Η43 85:L79M10F08 87:P77S11T05L03 88:-86W12 89:R91K04Q02S01 90:P57R39Q01 91:V80I15A02

92:V94L02I02 93:V65M24I08 94198101 95:C77V11Y06W02 97:H36Y29T22Q04V01P01A01I01

98:E60D28Q06K03 99:A88T07V01 100:V66I30L02 101:K57R34Q07 105:V78G11I06L02 106:D87G10 107:Q83K05H05R02N02 108:A94G04 109:E83D15 110:E53A29D12V01 112:S93G02A01N01

115:G92A03T02 116:E41T23K16M05A02H02Q01P01 117:I31Q26L19M11V06N01 118:A81P13T01V01 119:T50V21S16I08M01 120:L26F26V24I15Y02T01M01 121:D55E31N05Q02K02

122:R26P25W22K05Q05G04T03S02A02 123:L25I19T18V17N14F01S01Y01 124:F90V04M01I01T01 125:Q50K28D10N03E02R02H01 126:G90D04E02S01 127:Y64H25F04T02 129:V88L07I02

130:A35V26I14F12T04N01G01S01 131:F80L15M01 132:A51S45T01 133:N90S06T01 134:G96W02 135:E87D06K03N01 136:R92S03E01 137:W72A25S01 138:K76R23 139:Q51A18I11V07T06P01 140:L97M01 142:R86K09H01Q01 144:S82T15 145:L57I28M05T04V03 146:T39A38L12S03V01 147:T68A12I10V07 148:L69M30 149:R94K05 150:D79N16E01S01 151:F85L12 153:M73V24F01 155:K97R01 156:R87K06Q02 157:S56G27E11T02 158:I54V30G12M01 160:E95K01 161:R85L11Q01 163:Q86K09L01 164:E86A11D01 166:A93V03T01 167:Q53G34R05S02A01 168:C44F34Y15H01N01R01 169:L96M01 170:V50L24I22M01 171:E87K04Q04D01 172:E55A33M02S02T02 173:L57F37I04 174:R71Q18K05H03

175:K56G23E05N04S03D03A01T01 176:T66S23Y05V01 177:K38Q24R14E09N04H03G02C02 178:G92E05 179:A63R07K06Q03T03G03S03L02E01H01N01 180:P53L19F15Y03N02S01A01 181:I37F26L21V07Q05M01 182:D89E06N03 183:P96L01 184:T77S13I02L02 185:F70L13Y06M01N01I01S01V01 186:F41L35Y15I04P01 187:L63F32I02M01 188:S53H16Q14A11V01N01 189:R41S17Q15C13K04A04H01

190:T38A28I22V05S02M01C01 191:V53T43M01 192:S65A31C01 194:V56I42 195:I90V07M01

196:C57S38N02 197:S97L01 198:I70V15L12 199:V87I04T03L03 201:G98D01

202:D29E22K13S12L08N06Q02I01R01 204:F96L02 205:D67P09S06E05A03N03G01H01

207:E59K18Q08R03D03T03S01 208:D95N04 209:K53P16E09R08Q06H02T01

210:E53Q31R03K03T03D02C01 211:F98L01 212:L78Q17H01 213:S34R25A15K09H03N03E02T02Q01 214:L84V10M03I01 215:L79V10M07I02 216:R37D24Q13N07H03E03K02G02Y01S01A01

217:M46L34A12I02K01 218:M31F25I22A11L04T02V01 219:N27Y23L20G11F04S03T02Q01H01M01 220:G33E26Q25K03N03D02R02S01 221:S53T26I09V02M02F01L01 222:F78L10N03V02K01

223:Q22S16I12L11R10A09V05T04K02E01W01 224:L31F28E24G 11103 225:I30M24T24V07L05A03G01 226:S72A25 227:S55T40K01 228:P34F26S23L04A03T03V01I01 229:W39S25T19Y04M04F01L01

230:G45S34A16T03 232:L52V25T08M03F03A02I02 233:Y60F32L01C01Q01 234:E69D25N03

235:M61L29I04F01 236:F72Y21L03I01 237:S59Y13P11H05A01V01W01E01

238:S35G33W07R06D05N03C02P01A01 239:V33F28I26L11 240:L50M49 241:K66Q23R04N03D01 242:Y52H35P07F01R01 243:L55F40I02 246:P54T15R13A07S03I01 247:H70Q28 248:Q27R26T15N13K06H03S01V01 249:Q57R20K09E05H03 250:I41A24L19V13

251:Y43F27L11S07I03Q01V01T01 252:K52Y11R10N07H05G05S03D01Q01

253:N30E20L19H 12I06D04K02M01 254:L63I 16V06M06T02F01S01 255:Q50E25G09K05S02A01D01N01 256:E46G24T10D08K05A01V01 257:L60I25V07M05 258:E28K21N16A11L11R05I02H01

259:D54A21T06N03V03E02K01L01R01S01 260:F86Y12 261:I77A06V06T04M04

262:A42G22V11T09I05E02D01S01L01 263:K29Q15R14E14H13S10 264:K30S25R25Q12N04 265:V92I06 266:E53K27Q13R03 267:K30Q26I 12R11H05E04M03A02L01T01 268:N52H46 269:Q48R31E15K02 270:E32A23R21G09K04S04Q01D01 271:T72S19N05M02 272:L90F07 273:D96Q01

274:P82T07A03S02L01C01 275:S46N39Q09 276:S37N24A17G 11F02C01H01 278:-86A12

279:R90Q03K03C01 280:D92N06 281:F80V08L07Y03 282:I88V11 284:S33C25T23A14V01 285:F74Y25 287:I56L40V01 288:R51K31Q09H05 289:M96I01 290:E30Q26D15A10H10Y01R01 291:K47Q25E25 292:E83D14 293:K73E10Q08R02-01 294:S32K21Q15N13D05G03E02-01A01 295:N72D23K01

296:P84Q05H03S02 297:N45H23S09D04E03Q02G02A01T01K01L01Y01 298:T67S29 300:F97L01

301:H38N23Y16T13S02F01D01 302:H26M25L19E06D05Q04T02I02Y01V01F01 303:K72Q13R08E03T01 305:L96M01I01 306:V51I 19L16E05M05T01 307:L44M30I 15H03Y01 308:T85S10N03

309:T49V31S07A06I03L01 310:L81I07T05V02F02 311:N48S35Y11 312:L97V01 313:F86L12 314:F93I02L01 315:A95G03 317:T96S02 318:E86V06M05 319:T96S02 320:V61T23S11I03 321:S95G03 322:T62S27A07N01 324:L85V07I04M02 325:R90C02H01K01G01L01 326:Y92H03F02 327:G84T07A06S02 328:F78L18I02 330:L85F07I04 331:L76M21 332:L48M47V01 333:K96R02I01 334Ύ60Η35Ν03 336:E34H29D23Q08 337:V82I16 338:E39Q24A16T12L02 339:E48A44K04Q01 340:K72R26Q01 341:V76I 17L03M02

342:H57Q27R07Y05 343:E62K27Q03A02 345:I85L12V01 346:D67E09N09T07I01M01 347:R50Q44H02 348:V87E12 349:I84L12V02 351:S24R20P18K15A09Q04H03T02 352:H41N40G 12D02S01Q01

353:R91Q05H01 354:Q27L15A13112P11S07V06T02H01 356:A26K20S20T10N06G05Q04R01M01 357:L44F21V12I09Y04M04S01A01 358:E50D30G09N03S02K01 360:R93H03K02

361:A44T13V12S10M08L03I01N01P01R01G01 362:K71R17Q05N03 363:M87L12 365:Y97F02 366:T95M03 367:D60E34N02Q01 370:I86L13 371:H90C04N03Y01 373:I82A11V02M01 376:F66L25V03C01

377:G25S25A16T13L12I01V01C01 378:D78A12N08 379:L50I24M 14V06F03 380:I41V32L15A07T01 382:M58I22L13V03 383:G87S06N04D01 384:V56L27I10M04 385:P75A22S01 386:H63R36

387:R30M10A10T09N09K09V05I05S05C02L01 388:V82L10I03T02 389:T73I20N02M01 390:K61R30Q03C02 391:D81T12N02H01 392:T96I01 393:H27K21Q10C08L07E05R03S03T03N01Y01 395:R97Q01

396:G78D16E02N01 397:Y68F30 398:L40T19F15I 15H03V02 399:L66I33 401:K86Q12 402:G76N12D10 403:T96M02 404:E70D19T04N03 405:V92I06 406:F59Y36I01 407:P93A02T01L01 408:L37I33M22V05 409:L91I05M02 410:G56S34C02T02N01H01 411:S85T12A01 412:V62A31I02L02 413197M01

414:H47R25K14T04N04Q01 415:D98E01 416:P92S02T01R01 417:K44R12H10E09Q07T05A02N02S02C01 418:Y42F26H 10V09M03Q02I01K01 420:E40S27R11K10A03P02Q02

421:N25K24Q16Y10S07T03D03H02R02C01E01 423:D39E26Q12N06K04R03G02Y01

424:D26A23T21E14S04K02V02N01I01 426:N72Y15H06D03 428:Q34D26G20E10N02K02S01

429:H79R12N07 433:E42A42D11T01 434:N35K29Q13D11E06S01 436:R27Q27A25N04H03C03K02S01 437:F65L32 438:K88R09Q01 439:K95R01T01 440:N53S26Q07H06P02I01 441:E51D41A02N01P01 442:A96G02 444:V43M24L17I 14 445:P96A03 446:F97Y02 448:I37S22L19T08M06A02V02 450:K98R01 452:I44V19Y19N04F03L03A01M01 454:L72F23V02P01 456:E95D02K01 457:G69A17S10M01

458:L61I27M 11 460:R92K03L01Q01 461:M55A17T10N09S04 463:L98I01 464:F98W01 465:L96I02 466:F73Y15L08I01 467:F67L30V02 468:T97A01 469:T64S16A10N05I02 470:I89V04L02M02 471:L86M 12101 473:N76A10S05R04H01 475:S56R21T07H04C03Q02K01 476:L51F26V16I04

477:K33A15R13S11E10Q03G03D02T02H01 478:S80P09T04F02G01 479:P67L20S05E01T01

480:V43Q21C10K07M05L03S01T01I01 481:A40P34S09D04L03K02Q01H01 482:P88L05F02R01

483:E34Q19K17A11G09T02D02 484:D77A09E07T02 485:I81L15D01 486:D81S12N04Y01

487:L44V23I22F02T02E02 488:T44S35Q10A03K02 489:P96H01 490:K49Q20A11R09L03M01T01E01 491:E32V16H 13I12L08M04P04A01N01Y01 492:S52V25N07C04L04T01F01I01 494:F60L19V13I04

495:G44A32F11T05L01S01I01 496:N38T23K23R11S01 497:I65V17L12M02Y01 498:P94I02L01

499:P74R17Q03I01 500:T29N19A11V08S07F05P04K02E02D02I02L01R01 501:Y80F18

502:Q50T26E11K08R01H01 503:L40I30M25V03 504:S37C34R13Q11 505:F66L14V13A02I01

506:L53V17R09I07Q05M03W01 507:P72A20S05 508:R86T02H02I02A01L01

(xvi) N97

4:M98-01 5:D65A16E08S02V02G01Y01-01 6:L40P34A14V03S02-01 7:-71L22W02S02 8:-71G23E01V01 9:- 88L03V03I02 11:-71I 13T09V02 12:V29T25F24A07L03G02S02I02 13:V57I 16L13T06M01A01

14:V52A24I08F05L04-01G01 16:V66L22G06A01I01 18:L51I20V18F04T02G01

19:C55W17S08G06T04V02I01F01L01 20:L68V19M05I02A01F01 21:S68A14T05V04L02C02

22:C63F12T11S04I03V01L01 24:L91W03M01F01 25:L67I20V04F03M02S01 26:L79F15V01P01

27:L64I15F12V05 28:S81F13L02 29:L68I 14V09A02F01R01 30:W95R02L01 31:K41R37N16T01

32:Q77K08H04R03G02 33:S51I 12N09R09G05V03K02H01T01 37:-82YllH04

38:S60H 14Y11T02R02A01F01G01N01 39:G43S18A13K07E05R05Q02T02 40:R44K32W16G03 41:-97L02 42:G67-17R13 43:-98G01 44:K74N11R09Q01 47:P98S01 50:T75F17I02M01 52:L93F06 54:I85V06L04F03 55:I72V12L11F03 58:I61L18F07V04M04Y01S01 59:L81F13M02H01 60:Q96L01 61:L51I37V08M01F01 62:D68N22E05G02 63:V36L21I 16T09F06M03A01S01R01 64:K93R01N01 65:N52D46 66:I79V08M04L03F02 67:S55P25T03R03G02N02C02Q01A01 68:K75Q09A05E01T01R01G01N01S01 69:S95C02T01

70:L62F27I07M01 71:T44S38R04C02N02G01K01A01 72:N41K28R12M08S02D01 73:L73F25 74:S54A43 75:K71E24Q02 76:V42R16E09D08T05K05A04Q02S01I01 77:Y90F08 79:P97S02 80:V96I02 81:F89Y09 83:L63V35 84Ύ92Η05 85:F48L44V03I02 87:M46S24L09T08R03P03Q01 89:K57R16Q15E03N02T01W01 90:P73R24 91:T60V14I 11A06M02F01 93:V97I02 94:L89V06M03 95:H89Y08C01 98:E71K20D03N03Q01 99:A90V04I02T01P01 100:V89I05L03M01 101:K95R04 102:E96Q02 103:A83V15 105:I65L17V12D02 106:D88N05G01Q01T01 107:H34L24Q14R10Y07N03K01M01 108:G73K15S05A03R01 109:E69N14D13 110:E85D04V03I02K01N01 111:F97L02 112:S76A14L05M02 113:G90E03A02D01 114:R97K01

115:G88A02S02N01T01V01 116:S41E11R09H07D07N06I03P02T02A02Q01L01

117:F51119L12S04V04N02M01Y01 118:P93S02F01A01 119:V48I21A12L09M06G01

120:F29A26I15V07L07S06T02N01M01 121:E46D26Q14H03S02R02K01A01 122:K35R30D07A07E05N03V03W01L01 123:I24V18A14H11T11Y05L04F02S02M01N01

124:N42K14T11S07Q06A03F02R02V02L01I01 125:K49-17Q14R08N05E01 126:G75D13N04E02R01 127:L39H13K10F09Y08R05Q04N02S01A01M01 129:I78V15L05 130:I43V37L08T03A02G01F01

131:F91S03L02A01 132:S81N16T01 133:N82H06S04V01Q01R01 134:G97A01

135:K32E26N15P15T03R01S01 136:R39T31K10I06V03S01G01L01Q01N01 138:K93R04Q01

139:E50Q23D18A02H01V01 140:T36I29M21L06V04 142:R94H01V01 143:F95L03 144:S85T11A01C01 145:L93V03I02 146:M66T23S04L01N01 147:T74V16I07A01 150:N78D15S03 151:F53L17M16Y11 156:R68K15Q11E01S01 157:S57T19G14N05D01 158:I75N16L04V01M01 160:D59E22A04S04Q03N02H02 161:R93K02C01 162:V57I41 164:E79R14Q02K02 166:A93V02I02S01 167:R35Q20L14H13C04P03S03K02 168:C68F17Y06W02H01L01 170:V81L14M02 171:E89K03D02Q02G01 172:E70A26V01 173:L97F02 174:R76K20 175:K93E02G01N01Q01 176:T96S01 177:N58K20Q12E05R01H01 178:G54A41S02

179:S60Q26L07A01 180:P95L01S01 181:C71F24T01N01 182:D96N03 184:T89S06Q01A01

185:F91L03S02Y01 186:I60L28V08T01 187:L84I12V01 188:G72S15A05T03F01 189:C84F04Y03A03G02S01 190:A87V09G02 191:P95S02V01 192:C89S03Y02F02 196:C78A11S08 197:S80D16A01 198:I82V15T01 199:I60L25V13 201:Q58H19R11N07K01G01 202:N55K21E06D05R03H02S02T01 203:R87H11

205:D77E11Q03N03H02K01 207:K42N18T12S11D05E03R03Q01 208:D98N01 209:Q41K26E22P04R02 210:K23T21N17D15E08Q04H02R01I01V01S01 211:F76C07L06G04A02 212:L87Q06I01H01V01

213:N33T23R17K05S05Y03D02H02G01I01 214:L81F08I06M02 215:M64L16I11Q02A01V01

216:E39K21S09N07G06R03H03D03Y02 217:K35L28Y14R09I03N02M01H01T01V01 218:F52L36V05I04 219:N80H11D03E01L01T01 220:E91D02K02R01 221:N88I02D02S01C01 222:F42V17L14I09A05T05M02S01 223:R32K24Y13E10Q05H03N03S02T02L01 224:I65L25Q02R01T01 225:L71V08F06I04S03A02M02 226:S78N14G02T02 227:S62T33K02A01 228:P86S05L01G01R01 229:W96G01

230:I54L18M10V05C02A02N01T01G01 231:Q95E03 232:L40V37I15F02M02 233:C49Y45F02L01

234:N95S03 235:N40A19I08S08L07T05F03M02Y01 236:F84W05L04Y02V01I01 237:P86S10A01

238:A24S18I12V09F08L07D04P02T02K02G02N01M01 239:L66Y12F11I07C01V01 240:I50L29- 07M07R02V01 241:D53H20R09K05Q02Y02N01V01 242:Y85H05C03F01V01 243:L60F23C10M02Y01 245:G98W01 246:S69T08E04I03K03R03N02P01C01 247:H95Y02 248:N45R23K15H09T01Q01S01 249:K62T12E05A03V03Q03R03I02D01 250:L41V21F17I15A01M01

251:L33F31110M08S05A02Y02T01V01H01 252:K85E04N03Q02R01T01 253:N88R04I02D01H01V01 254:V28I21F20M06L05Y05S03A02T01H01 255:A38S15T11N09D06E04K02I02Q02Y02F01

256:Y31E29D08F08L06N04W01K01C01H01G01A01 257:I35V17Q16L14T06M04F01A01

258:K75R11I02H02Q02E01F01N01 259:S35N19K14D08E07Q04H02A02Y01 260:Y65F33

261:I48V19L09A08F07T05 262:L77S07M07F02R02A01 263:E85K06A04G01 264:K70R21E03Q02G01 265:V50I36T06A05 266:K88R03Q01E01A01 267:E91D02K01R01Q01 269:Q82E04L04H03K02

270:E62A12K11Q10D01 271:S86T09I01 272:L95M02 273:D92N03E02

274:I32P22V18L08M06F03H03S01A01 275:N67S10T08D05A03H02 276:N78C16S01D01 279:R87Q11 280:D98G01 281:F82Y10L03V03 282:I81T15V01L01 284:C64Y28T02S01H01 285:F71L15Y10M02

287:I75S07M06V03L02T01A01 288:K75E16R04Q03 289:M84R04L04I02G01Q01 290:E77K07Q05R03G01A01 291:Q58K37E03 292:E88A03D02-01 293:K82N09R03-01S01

294:H65Q08D07N05Y04G02K01C01-01 295:N73S16I03K01E01

296:Q35K20P19A07E05S02T02G01H01L01N01 297:Q47E23K08H07D03N02P01S01

298:S63P13L10T05M02R01 299:E71M04L04V04G03Q02K02W02I01A01D01 300:F76Y21

301:T79N05D05S03H02I01 302:L33M23I21F05V04T03Y03C01S01 303:E71D23H01G01

304:N80S08H04G03A01 305182115V01 306:A24V23I23T10L05S04M04E02K01

307:V23I22T16A15N04M04G03S02F02Y01C01 308:T83C04S03A02L01I01M01 309:V55I 16A11G08L05T02 310:S24A24W13T12N05F04L04V04G01I01 311:D91N08 312:L79V11M06I01 313:F92L05V01

314:G33F19S16A12V08T04I02D01 315:A97G01 317:T93I02S02 318:E93Q01D01 319:T97S02

320:T94M02V01L01 321:S95T02 322:T81S11I02L01A01 324:L88M09I01 325:R89K08S01 326:Y91F07 327:G71A22S04 328:L97F01 330178117V02M01 331197102 332165M32I01 334:H67Y31 335:P95T03 336:E83H08D04K01Q01 337:V77I22 338:T60E20Q06A05S04 339:A77E19D01 341:V69L17I08A04 342:Q67H27R03 343:E93K04 346:D70E19H03N03A01 347:R71H18Q03C02N02S01 349:I75V24

351:R73P17K04H02 352:H53N21S14D05T02E01 353:R93Q05 354:S71I 16V03R02L01T01 355:P97A01 356:C74A15S09 357:M78I 13V04L01 358:Q69K26E01R01 360:R88K11

361:S60L14N05M04Q04T02G02I01V01A01 362:H34R23E12S07K06D05N04C02Q02 363:M95L04 366:T71M24L03 367:D87N06E05 369:V80M 12L03T03 370:V63I20L14 373:I76V22 376:Y65F33

377:I93V03T01 378:D76N 16T06 379193I03F01 380:V46I28L18A02G02 382:T39S24N24I04L03V01 383:N64S25G06P02 384179V16M01I01 385:P92L03V01 386:H94R05 387:A68E19T03K02S02V01M01 388:V69A22T06 389:T87N05V02A02I01 390:C33Q30R26H03S02T02 391:D94N05 392:I44T27V25L01 393:K64Q08V06M05R04E03H02I02T01 394:F97L02 395:R94Q04 396:N50G22E13Q09D03 397:Y97F01 398152V19F15I06T02H02 399:I97L01 404:T54V14N06A05D04S02I02E01H01G01Q01L01 405:I58V37L03 406143I37M06F05V05 407:T52P33A05I05V02 408:S65T16L12C01D01 410:T58S23D16 411:S97P02 412:V84L11I02 413197M01 414:H57Y27F04R02L02N01K01 415:D95N02S01

416:D41S20N15E06K04C03G02R01A01 417:K76Q18T01 418:E95A01Q01 420:P91S04

421:N76D14E03H01K01 422:P98A01 423:E78K07D07G02N01Q01 424:K34V17Q12T11M08I07R04E02 426:D81K15N02 428:G70E16A04R02Q02H01S01 432:D84N15 433:E66K21A04D04G03

434:S44N41K03G03R02H01D01 436:N63K26S07C01 438:K90R08 439:K81Y16 440:S92T05N01

441:D91N04E02 442:Y87H08C01 444:M67K16V08L03I02F01 445:P65A32V01 448:A64T22I06L03S01 452:I33V32A15M 13S02 454:V59A28L08I02M01 457:G82S10A06 460:R94K01Q01 461:M97V01 463194M02V02I01 465197101 466:F74L16I07 467191F06 468:T82S09A03V03 469:T62A17S13N04 470:I96V01 471198V01 473:N51H29K17Q01 475:T42N36K12S03V01H01 477:K96Q01E01 478:S58P40 479169V20P03Q02E01 480:V83I05G04T01L01D01 481:D79E08H06N02P01 482:P87L05T03

483:K89E04N02R01 484:D82E08N06H01 485:I76L21V01 486:D84N08E04S01

487:T56I 18L15V03P01M01A01 488:T70S13K09N01A01I01 489:P90A04S02N01

490:V47I28L06A04T03N02M01K01S01 491:V27A24T14S06H05L04N04F04D02Q01Y01

492:N44S15I 14K09T08V05R01 493:G92T02A02S01 494: F65L23I07V01

495:G35A26V13I06S05L05T03N01F01 496:S57N11H07K07R06C04T02A01 497:V52I27L15M02A01 498:P96L01 499:P94R02H01Q01 500:S28F17P15H11L05R04E03N02T02A01K01Y01 501:Y85F13

502:Q49K32E15R01 503:L82I09V03M02 504:C92S03R02 505:F76V13L08 506:I82L07V06T01

508:V55R26L04I04S03A02H01M01

(xvii) N98

1:-95M04 2:-95A04 3:-95L04 4:M95-04 5:E87D06-01G01M01 6:L72P20T02-01 7:L91S04Q02 8:G92E02S01 9:A62T12G09M08V02I01 10:-98W01 11:A52T20S08C05V05G02I02-01 12:T85S08-03A02

13:V79A07L06G02I02-01 14:V61L25F08I04 15:L95V03 16:L70V29 17:-97L02 18:V77L10I09T02

19:C90W05L03 20:I87L06F02V02 21:A62S33F02 22:C90F06L02 23:-95L04 24:L97F02 25:L97F01

26:S64L24F11 27:F57S22L10V04I04 28:A81T07S04L03V02 29:A65T10V08F05S04L03I02 31:R57K41 32:G52S18K16R08A01V01 33:R73K12G08Q05 36:-95G0437:-97K02 38:S70A15M04R04P02-01

39:G72R08N07Q05Y05 40:K73R12G05N04Q02 41:-92L07 42:G75K14R06-01E01 43:-73G22T02R01 44:K95R04 45:M84L15 50:A58T29V05S02W02 51:P95S04 52:L93F05 54:I90L08 55:L70I26F02

58:V50A18L16M 10104 61:V62L36I01 62:K91D04N03 63:P62T26G09 64:K80S09N07H02

65:N65H14Y06D05A03S03E01 66:L88W05P03M02 67:A58D21S08P03T02F01Y01 68:K69Q17L05R04E01 69:T75A08S08E04V02 70:L85F11I01Y01 71:Q57C12H09E06S05M04N02 73:L83I13M02 74:S93G03H02 75:E91K04Q03 76:E64K28T04S01 79:P95S04 80:V97I01 83:V75L21F02 84:H71Y26W01 85:L78F17M02V01 87:S74M13T08F01P01 88:-95W04 89:D58E17N08Q07K05A02 90:P89R10 91:V89A10 93:V94M04 95:H78Y08N07C04 96:G97R01 97:H52Y46 98:D62E26G03S03N02Q02 99:V62A36 100:V85I13 102:E97D01 105:V58I38L03 106:D94E03N01 107:R76H13Q09 108:A73G26 109:D75N13E10 110:E80D16K02

112:A83S13V02 113:A66S12G10P04F03V01 115:G87A11 116:H58K17R12A03N02E01I01

117:M79I 15V02L01 118:P93A04H02 119:I69L21V06 120:G67I20L04V04A01M01 121:D79E15Q03 122:R67K31 123:A57T11I09L06V06Y04F02 124:N75S08F06T04I02 125:N64K23Q03R03E02S01 126:G97S01 127:L68K13G05Y04Q02A01F01 129:I94V04L01 130:I66V30M02 131:F97V02 134:N63G35 135:E82K13N02 136:E50R25T08P05L04Q04G01 138:L63K35 139:Q93E05 140:V58L33A04I03 142:R91Q08 144:A73S15T11 146:T53S46 147:T96A02 148197F02 150:N97S02 156:R75K25 157:S96T02 158:I95V02T01 160:E95M03 161:R95K02Q02 163:Q90H04R04 164:E90K04G02D01 166:T42A34S19I03 167:E50Q36D12

168:Y91H04C02F01 169:L95F02 170:L84V15 171:E94K02Q02 172:E70Q16K05R04A02 173:I63F18L17 174:N57S10H08Q08R08T03D02 175:K66N09D08S06G05E03 177:K91Q06N01 178:G76E09K06Q04R03 179:T52Q24K08M08A05E01 180:P94A04S01 184:T84H12 185:F83Y12N01 186:M56L35T05I02

187:L86F08M04 188:S83G05N05I04T01 189:C95N04 190:A85S09T04 191:V75T17I06 192:S98A01 193:N95S04 194:V82I17 196:C93G06 197:S97C01 198:I91V05T01 199:V86I12 201:G98A01

202:K88E04N03Q03 203:R83H 13-01 204:Y90F07R02 205:D89G06E04 207:K66E14D08N08 208:D98N01 209:K96R03 210:K90R04Q02N01 212:L86Q13 213:A69T18S11 214:L81I07F05M05 215:M81I08L08 216:N64T10A09D06G03K02S01 217:N63L23I05K02Q02S01 218:M80I09L06T03 219:N86V05D04I02 220:N58E25D10S02T02 221:I69N20S05T02Y01 222:F87I08T01 223:E76H06R05D04Q03S01

224:M64I 16L11V03F02 225:M56F15L14V06I03T02 226:N80S13T03A02

228:H42P16R12Y06A05I04G02Q02V02F01L01 229:W96C02 230:G95A04 232:L75V20F04

233:Y66H16A09F05 234:Q50N26S20Y02 235:M69L10T09I04A03F02 236:F98Y01 237:S54P45 238:K34N24S20A08R04T04 239:I62L22F13V01 240:L56M43 241:D77E13Y04N03 242:Y66W19H06V04L01 243:L75I16F04V03 247:H96Y02 248:N68H21Q07K02 249:K52N16R12H08Q06Y02 250:I75V12M10L02 251:F75I08V06G05A03 252:T33A24K16S08R04D03G02I02Q02 253:E63N28G04S01

254:F72S08V05Y05L04I03 255:D68E13V08L04A03 256:A56K22D05E05R04S02 257:L79S10C06A01V01 258:K91E04R01 259:A67E19D08K03 261:V77I21 262:S57L17A16M05R02 264:E92R05Q01

265:V73A16M07L02 266:K92E07 267:M29I17E16L12K08A05T05R02V01 269:Q70R21E04K03

270:A78E12D04Q04 271:S66T33 273:D96E02 275:S72N23T03 276:S97C02 278:-95A04 279:Q66R33 281:F92Y04L01 282:I96V02 284:C97L02 285:F98Y01 286:L83F08Y08 287:S47I32N11C04T03R01

288:K91R08 290:Q60D21E15H02 291:E65Q33 292:E97D02 294:E48H16D15Q12N04K01

295:N42H35R12D05C01K01 296:P70E20D05G02A01 297:N65A19K08S03P02 298:S97T02

299:S58E35N01T01 301:H69T21Y04N04 302:M79T04I04L04E02Y02V01 303:K61E38 304:N96S03 305:L89M06S02V01 306:I70V23L05 307:T78M17 308:S66T18C15 309:T64A14S08C08V03 310:F69L19I10 311:D93N05 314:I58G18F07S05T04L04 315:A95G03 317:T98S01 319:T95S04 322:T95S04 324:L41I39V19 325:R94K05 327:G97S02 328:L94F05 330:L68I26V04 332:L75Q23 334Ύ94Η04 336:K61E29H03D02-01Q01 337:197-01 338:Q75E23-01 339:E97-01 341:V88I10 342:Q91H08 343:E93K04Q01 347:R62Q28H04F02W02 349:V82I16 351:R94Q04 352:S85N04A02D02M02T02 353:R97Q02 354:R44K20M14S13L04 355:P97A01 356:C79S10G06A03 357:V61M33A02 358:A93E05 359:D96N02 361:T55G16S12A06R05I01P01

362:Q87R06K05 366:T96I02 368:A98T01 370:V67I26L04 377:I91V04L02M02 378:S79A09D07T03 379:L94I03V02 380:I50V41L03A02T01 381:P93S06 382:L83V07M05I02 383:S37G32A30 384:L79V18I02 386:H95R04 387:T65A18S13M02 389:T65A10V08S05D04I02N01 390:K83Q07R07N01

393:C30P26H14S10Y04R03L02E01N01Q01V01 395:R97G02 396:E47G26D16Q08 398:V69I20T08L01 402:G94D04-01 403:T98-01 404:T95S03 405:I80V18 406:F80Y11I03V03L01 408:I47V33L14S03

410:S68T21D04N02 414:H94Y04 416:S80G09P05 417:K97N02 418:E93Q05 419:F97W02 420:P91K05R01 421:N97D02 422:P96A02 423:N49T20E13H09D03 424:E83Q09T03K02 426:N75D24 428:G75E17Q06 432:N84D07K04S02 433:E62K30P03A02D01 434:N74D22S03 436:T84S12A02 438:R87K12 440:S93N05 441:E48D37N10K01 442:F72Y20A05L01 444:M90V04I04 452:I87M05V04L01 454:P62A20L14V03 457:G92S07 458:L95M04 463:I70L29 465:L97M02 466:L48F43I04V02 467:I38L27F12M09T08V03 468:A56T35V06S01 469:T75S20I03A01 470:I95L04 473:N93K04 475:T77K21 476:L96F03 477:K96R03 478:P83S12A04 479:V60L28I06F02T02 480:V63T20I08M03E02 481:D80N18 483:Q67K24E08

484:E71D25K02 485:L61I38486:N51D41S07 487:I84L11V04488:T70S13K05M04A02I02

490:T59E09A05H05L04M04R04Q02V01 491:L79V08E04K04M03 492:S91K04G03 493:G80S12P04N01 494:T62F10I09M08L07V01 495:G78S08N08M02T01 496:N94R04 497:V71I12F05L04M03A01 498:P98S01 499:P66R20Q06H02K02S01 500:A49P31V12S04 501:Y96F03 502:Q77K12E05R04 503:L86F13 504:C98R01 505:A68V22L04F03 506:L50V30I16F02 508:R96C03

(xviii) N112

1:-81M18 2:-81A18 3:-81L18 4:-51M48 5:-39E21M18V09D06L03N03 6:-27L27M24T09A03F03G03l03 7:- 84S15 8:-87G06S06 9:-87V09A03 10:-93W06 11:T57-21C09G03I03L03M03

12:M45T18S12L09A03D03E03G03I03 13:A33L24S24V06F03G03T03W03 14:T51I21L15A06C03V03 15:L45V39G06T06S03 16:L66V27F03T03 17:-90L09 18:L87T06A03P03 19:L87A06C06 20:L87S06C03P03 21:L72S18I09 22:L81A09C06F03 23:-84L15 24:L54V30M09A03T03 25:L96M03 26:A60L21C09M06V03 28:A60S15L12V06M03W03 29:W33R30L27A06S03 30:W63R27A03G03Q03 31:G57R30A03C03S03W03 32:W60K27R06Q03V03 33:G72R15V06-03L03 34:A69-12V06L03R03S03T03 35:R42-21Q18H09K09 36:G63R21Q09S03V03 37:A33T33K18-09S03V03 38:Q51R36-03G03K03L03 39:T42R33M 15-03I03P03 40:R60Q33G03P03 41:-84L15 42:G72K09R09-03E03S03 43:-84G 15 44:A39R30G 15D09P03V03

50:T69A21R06M03 51:P96A03 52:L96F03 53:P96G03 54:L90V06Q03 61:L93I06 62:E48D27Q18G03R03 63:S66T24P09 64:G36R36K21Q03S03 65:R48E15A12H 12G09D03 66:L75M 12P12 67:D72L12F06Y06H03 68:R60K30C03H03Q03 69:A48S27V18R03T03 70:L87F06Y06 72:E69K30 73:L96V03 74:S96E03

75:G45E15S15R09K06Q06P03 76:R63K27H03N03S03 77:W66Y27F03S03 78:G96S03 79:P93F03S03 80:V96L03 81:F93-06 82:T96E03 83:V96M03 84:R39W36Y12H09G03 85:L96Q03 87:P63S27A03L03R03 88:- 81W18 89:R60Q30G03H03L03 90:P96T03 91:A66V27F03P03 92:V96G03 93:V96C03 95:C90S06N03 96:G93E03S03 97:Y93S03W03 98:E36A27S27T06H03 99:A96P03 100:L72V27 101:R72K27 102:D75E24 105:V96L03 106:L69D21N06R03 107:Q84H15 108:A84G 15 109:D75E24 110:A36T33E27-03 112:S96G03 114:R96P03 115:G87A09R03 116:A66D09-06E06G03S03T03V03 117:M75I 12-06H03T03 118:A54P33- 06D03G03 119:V84-06A03C03S03 120:F75L24 121:E60Q15D12Y09R03 122:R93L03T03 123:F75I 18C03L03 125:R48K27H15C03L03S03 126:G96R03 127:N78Y18K03 129:I87L06V06 130:V78A18L03 131:F90V09 132:S96F03 134:G93R06 135:P42E27R18A03H03L03Q03 136:R93A03L03 137:W96L03

138:R45K27L12H06A03P03Q03 139:T66Q18V09K03S03 142:N66R27T06 143:F93L06 144:A66S15T15H03 145:L93M03V03 146:G69T18Q09N03 147:A66T30V03 148:L93-06 149:K63R27-06E03 150:E66N27A03K03 151:F87L09E03 152:G93L03R03 153:L42M33V21R03 155:T51K30R12A03S03 156:R87S09L03 157:T60S39 158:I93M03V03 160:E90D06K03 161:R93H06 162:I84V15 163:L66Q30R03 166:A96T03

167:A63Q27D03S03V03 168:C78Y18A03 169:L87V12 170:L66V30P03 171:G54E15Q15D12S03 172:E90A09 173:F96L03 174:Q72R12S12A03 175:A69K18E09V03 176:T96I03 177:I24K24V21M09T09A06Q06

178:G96E03 179:A66K09T09V09Q06 180:P96L03 181:F96L03 182:D90N06G03 184:R66T24I03L03Q03 185:R63F24Q09S03 186:L96H03 187:L96I03 188:D66S27G03R03 189:N69C15R12S03 192:S93A06 197:S90T09 198:V78I 18M03 201:G96R03 202:K36N27E21Q09H03S03 204:Y72F27 205:G51D42N03T03 207:E51G45T03 209:P72K24A03 210:E69K15Q09D06 212:L87R09Q03 213:R69T30 216:D69N27E03 217:L87I12 218:F72I24L03 219:N45H39S15 220:D72E27 221:N81I06T06Y06 223:R69Q18S06C03H03 224:I78L12F09 225:M87V09L03 228:R66P27K03Q03 230:G96A03 231:E72Q24L03 232:M54L27T09I06A03 235:I87M09V03 238:S87R09T03 239:L75F18I06 240:L63M36 242:W81H18 243:L75I21F03 248:H96N03 249:R78K18Q03 251:F96L03 252:R36Q30K18A09G03S03 254:F87V12 255:E33A24T24Q15K03 256:E69K30 258:R69K24Q06 259:V60D27L09A03 262:S72A18R09 264:Q69R24E03K03 265:I72V24T03

266:Q69K15E06R06P03 267:R66M09Q09W09K03S03 269:Q54R39K03W03 270:Q63E36 271:T81S12L03R03 272:R69L27Q03 273:Q72D27 274:P78T09A06L03S03 275:G60N24E09R06 276:E66S27K03V03 277:P96A03 278:-81A18 279:R96H03 280:D96N03 281:F87Y12 284:C96F03 287:D66I27A03E03 288:Q72K27

289:M96I03 290:D66E33 291:K69Q21E09 293:Q60K30H03P03R03 294:Q78E 15K03N03 295:D81N18 296:P90A06L03 297:E66N 18Q09K03R03 298:S93G03T03 299:H81E18 301:Q66H21N06R03Y03 302:E48D18M 18Y09L03R03 304:T81N18 309:T90V09 310:H81L12F06 311:N93D06 315:G78A21

318:E96K03 323:T96A03 324196103 325:R96H03 327:G90S09 328:L81F15I03 330:I90V09 331:L84M15 332:L78M09Q06P03V03 334:Y96F03 336:E81H12N03Q03 337:V78I 18M03 338:A75Q24 339:A78E21 341:V90A03L03M03 342:Q81H18 343:A57E27K06Q06S03 344:E93-06 345:L63l30-06 346:D93-06 347:A60R27-06E03S03 348:V87T09M03 349:V69I30 351:R93Q03W03 352:A33T21N18M 15D09S03 353:R87H06L03W03 354:A39S27T27P06 356:R57S18A12C06N03V03 357:L75M 18I03Q03 358:E90A06G03 359:D96N03 360:R96H03 361:A57E18S15D03K03V03 362:R69K15H12C03 363:L72M27 367:N69D27S03 369:V90-06M03 370:L69I30 371:H96R03 376:F96L03 377:I90L09 378:S75D24 379:V72I21L06

380:L72V18I09 382:L69M30 383:G87S12 386:R69H30 387:A84M09I03T03 388:L72V27 389:T96I03 390:R96Q03 392:T84V09A06 393:H78N09E06Q06 394:L69F30 395:R87H06C03K03 396:G81N09S09 397:Y51H45C03 398:F63T21L09I03S03 399:L78I 18V03 400:P81H12R03T03 402:G96S03

404:F63N15T15M06 405:V96I03 406:I90F09 410:V57S27A06M06I03 412:A48V27S24 413:H78L21 414:R66H27Q06 416:P96S03 417:T81K18 419:F90W09 421:D75N24 423:D69E30

424:C48H 15A12T12S06N03R03 428:T57G 12E09N09D06A03S03 429:N72H27 433:D69E30

434:K63N18R09E03H03Q03 435:G96S03 436:E63S27A03K03N03 438:Q66K30R03 439:S51K24N21T03 440:N96K03 441:D87E12 444:M96L03 447:A72S24G03 448:P66A24L09 451:R93L03P03 452:M78I 18V03 456:A72E24T03 457:G96S03 460:R90-06H03 461:S69M30 463:I72L24M03 464:F96I03 465:L96F03 467:L57F42 469:A63T36 470:181L12T03V03 472:Q96H03 473:R51K24N15H06Q03 475:C51T30S09R06H03 476:L87F12 477:L69K12R09Q06C03 478:P93A03S03 479:V54L27-06T06E03M03 480:G51E21V18-06K03 481:S57D21A06N06G03K03R03 483:A60E30S06T03 484:N54E30D06S06R03 485:I96V03 486:D84N15 487:L93I06 488:T90S06N03 490:Q72E12A06H03K03R03 491:C51V21Y21R03S03 492:T75S24 494:L81F18 497:V54I33M 12 498:P96S03 499:P72R27 500:A60P21S09G03T03V03 501:F75Y24 502:Q93E03L03 504:R51C24H21Y03 505:L84A12V03 506:V81I 12K03M03 507:A69P30

(xix) N117

1:-95M04 2:-97A02 3:-97L02 4:M94-04 5:E83A04M03G02-02D02 6:L50A25P16F03-01T01 7:- 71A19S03T03V01 8:-72G21S03 9:-72T23A02V01 10:-74W24 11:S64A22T06G02-01L01 12:V49- 25A08I06T04L03S01 13:L88I04V02-02F02 14:L95-02I01 15:L82F13-02V01 16:L68V12-08A05F03 17:-98L01 18:A48L24T14I06V02-01S01 19:L76V15C02A02F01I01 20:L87F08T01 21:L35T31V14I05M04S03A03-01 22:G67L23S02C01-01A01V01 23:-98L01 24:L69F22V04-01 25:L90V06F01 26:L60T12V09A08S03I02F01P01 27:L97F02 28:L57A19-06M06V03S02W02T01 29:V28L27A20F10-08T02I01 30:R53P20W08Q05K04S03- 02L01 31:G69R18-04A04S02 32:H46T17Q11R05K04Y03-03S02C01P01 33:P67R22S02T02W02A01 34:- 73A14T09 35:-73R20P02G01Q01 36:-97G02 37:-98K01 38:K58-26N04T03R03A02 39:A44- 26S11T07R03I01G01P01 40:H41-26R20Q04Y04 41:-98L01 42:G94S01-01R01 43:-98G01

44:H62R26N03C03Y01Q01 45:L97F01 50:R56A16T12W07H03P01S01 51:P96V01 54:L49F44I03 55:L98F01 58:L86I08V04 60:Q97H01 61:M61L31I05 62:D65R25N06 63:R63P24H05T02Q01L01

64:G36K29R27N02S02Q01 65:G69A25E02 66:L88F09P01 67:L66Y24V03F03

68:K51N18S17L04R02Q01A01P01 69:S71G24T01 70:F66L25I05 71:L61M 19Q08I05R02K01

72:R50Q21K19A05L01 73:L78F14I05M01 74:R56S29Q12 75:E59K26D08Q02G01 76:K95Q03R01 77Ύ97Η02 79:D68P29 83:V91L04I03M01 84Ύ62Η35 87:P80S14Q01L01R01T01 88:-70W27R01 89:R90K05Q03T01 90:P73R24S01 91:V91A05 93:M51V36I 11 94:L97I02 95:C65V25Y06W02

97:T48H22Y13V04P03A02I02Q01R01 98:E74D12K06Q05 99:A84T14 100:I60V37M01 101:R73Q15K11 105:V73G24L01 106:D75G21E01N01 107:Q87H07N04K01 108:A95G02 109:E91D07

110:A61E29D02S02V02T01 112:S95A01N01 115:G94A03T01 116:T42K27M 11H05P03A02E02I01R01 117:I64L20V12M02 118:A94P03T01 119:V45T29I 16M03S03A01 120:V43L36I 11T03M02A01F01

121:D55E31Q05K04H01 122:P54R11G 10Q07A05K04S04L01 123:V34I33T29L01

124:F83V06M02T02I01L01Y01 125:Q62D21K05R03N02M01E01G01 126:G82D09E04S02

127Ύ63Η26Τ04Ρ01 129:V87L08I02M01 130:V34I29F26N03A01L01G01 131:F96L01V01 132:A69S28V01 133:N95S03 135:E78D08K07N03 136:R87S07H02C01 138:K75R23 139:A40Q29T14V13I01 142:R76K21Q01 143:F96C01L01 144:S67T31 145:L71M 12T07V05Q01 146:A58L26T10V03 147:T74A23S01 148:M65L34 149:R93K06 150:D92N04E02 151:F72L26 153:M98I01 155:K97R02 156:R92Q04P01 157:S69E25T02 158:V59G26I 11M02 160:E95K02D01Q01 161:R71L24Q02 163:Q83K15R01 164:E74A24 166:A89V07T01 167:Q86R11K01 168:C86H02N02R02Y02S01F01 169:L95M03 170:V92L03I03 171:E93Q03K01 172:E71A25 173:L70F27M01 174:R62Q26K07S01 175:K67G 14E07N06R01S01T01 176:S49T39Y07M01

177:Q48K29E18R01A01 179:A59R15G07Q06H02S02T01D01K01V01 180:P49L39Y06A01F01

181:L43F28Q12V11M02 182:D94N04 183:P97N01 184:T58S26L05I03K02H01V01 185:F67L26M03S01 186:L70F23Y03I01 187:F69L30 188:H35Q31A24S04N02 189:S36Q26C24A09R01 190:I48A35V11M02 191:T91V04M02A01S01 192:A67S30C01 194:I82V16 195:I83V14 197:S95L02T01 198:I70L26T01V01 199:V76I09T07L05 200:F98L01 201:G96D03 202:E45K24L19Q04I02R02 203:R98C01 204:F93L05

205:D44P20S14A07N05G03H03E01 207:K38E23Q15R08T06D05S01 208:D97N01

209:P35R17E16K13Q06H04G01T01 210:E44Q41R05K02V01D01 211:F97L01 212:L71Q25R01

213:R53A24H06K04T03Q02E01N01 214:L69V21M05I02 215:L73V21I04M01 216:D49R18N14Q08H03E02 217:L65A25M04I01 218:F50A25I 10L08M03T01 219:Y48G18N12F09S06C01 220:Q49G25E11K05D02R02 221:T49S31I 13V02Y01 222:F67L21V05A01S01Y01 223:S35L21A20V06T05I03R02D01M01E01N01 224:L63G23I08E01F01 225:I59V16L08M08G02T01S01 226:S97G01 227:S97T01 228:F56P28L09I01T01V01 229:S54W29Y09F03G01P01 230:S61G32T04A01 232:V53T18L11M08A04S01 233:F67Y28L02

234:E94N02Q01 235:L64M26I04F02 236:F86Y06L05 237:S82P11H03R01

238:G41W14S13D11R11N04Q01A01 239:F54I22L17V05 240:L94M05 241:K73Q19R04D02

242:Y47H30P15R02F01L01 243:F69L30 246:P36T33A16S06I03V02K01 247:H97Q01

248:R54T25K06V03H03S02A01 249:Q71R10E09K03H02D01 250:I48L32V18 251:Y45L21S15F06Q03T02N01 252:K50R19G 11S06H06N03A01 253:N61H25K04I03M02 254:L69V10I07M04F03T01

255:Q64G 18E06S04D02K01 256:E68T22K03I02V01 257:I54L29V14M01 258:N31A25L22K10I03E02G01S01 259:A42D31T14N03V02R02S01E01 260:F76Y23 261:I69A14T09V06

262:G47V16A12T07I04D03S02E01N01R01 263:Q28H27R25E13K02 264:S54Q26N10R03V01I01K01 265:V91I07 266:E68Q25K03G01R01 267:K54R23Q12E05M02T01 269:R66Q26K03E01

270:E49G 19A16K06Q02R02D01V01 271:T67S14N11M04R01 272:L95F01V01 273:D93Q02G01H01E01 274:P72T17A06C02S01 275:S89N07T01A01 276:A34G24N22S12T01V01 278:-70A27P01 279:R82K07Q05C03 281:F64V17L14Y02I01 282:I74V25 284:T50A30S09C05V02 285:Y54F44 287:L87I10V01 288:R62K29H05C01 289:M97I01 290:E41D33A23 291:K78Q19E01 292:E88D09 293:K74E14R04S01 294:S63Q25A02L01E01K01G01 295:N51D44 296:P73Q12H06S03L01 297:N37H32E08S07D06G04Q01Y01 298:T70S25V01M01 299:E96Q01 300:F95L03 301:H64T25S03D02N02Q01

302:H56E14D10Q09Y02M02A01F01L01N01 303:K55Q27R09E05 304:N97D01 305:L96M02F01

306:I38L28V22M 10 307:M35I32L18H06Y02N02F01 308:T73S19N06 309:V64T13A09S09L01

310:L70I13T10V03F02 311:S66Y24N05A01T01 313:F73L26 314:F96L01 315:A97G01 318:E73V14M12 319:T96S03 320:T49S24V22I04 321:S93G06 322:T79A16N02S02 324:L75V15I08T01

325:R87C05G02H02L02S01 326:Y94F02H01 327:G70T14A11S02 328:F67L31 329:L98V01

330:L82F09I06V01 331:L55M43 332:L93M04V01 333:K96R02 334Ύ90Ν04Η04 336:H62Q18E08D06G01R01 337:V74I24 338:A33Q28T28L04R01I01V01 339:E87K08Q02 340:R54K41Q02 341:V93I05

342:Q55H23R15Y05 343:K58E31A05V01 345:I72L26 346:D53E19T15I04M03N02 347:Q61R34E02 348:V73E26 349:I71L26V02 350:G96P01 351:S50A20P19R05E01T01 352:H61G25D03N03Q02Y01S01 353:R85Q09H02C01 354:L30A27P23Q07V04S03G01 355:P98R01 356:A42T20S19G 12E01N01V01 357:L95M03 358:D46E20G19N04S04K01Q01 360:R98Q01 361:A57T27S05V05I02P01

362:K65R27N04Q01H01 363:M73L26 365:Y98F01 367:D78E21 370:I71L28 371:H86C08Y02R01

373:I70A24M02V01 376:F71L27Y01 377:S33L27A21G15I01 378:D73A26 379:L91I07V01

380:V37I29L23A04T03S01 382:I48M36L07V04F01T01 383:G95S04 384:V64L13I 11M08A01 386:H76R23 387:A18M 17K12V11T11I09R07S05C04 388:V75L21I02 389:T88I07M02 390:K70R21Q06 391:D68T25H03 392:T97I01 393:H35C19L16R07S07N02Y02M01Q01P01V01 395:R98Q01 397:Y88F09H01

398:I29T29L23H07V03F03Y01 399163135 401:K75Q23 402:G58N26D15 403:T97I01 404:E85T08D02N01 405:V93I05 406:Y52F44I01 407:P94L02T01 408:I59L34V04F01 409:L90M05I03 410:S61G26T04N03H03 411:S84T14A01 412:A60V32I05 414:H86N08R02 416:P95S02L01

417:H22R21E17Q15K07C04A03N02S01T01L01 418:Y52V20H 17I03Q02F01 419:F98W01

420:E84K06Q04D01G01 421:K48Q35N07E02H02R01T01 423:D57E34N03G01Y01

424:T41E26A17D04S03V03K01I01 426:N83Y07H06D01 428:D57G31E07N01 429:H72R27

433:A88E05T03D01 434:N49D22K11E10Q03S01 435:G98E01 436:A55R20N09K05S03T02H01Q01 437:L62F34V02 438:K79R16Q03 439:K95T02R01 440:N43S16Q15H13P04T01I01M01 441:E82D12K02P01 442:A95V01G01T01 444:M41L31I26 446:F95Y04 448:L36I32M 13T10A03S02V01 450:K97R02

452:I63V24L06M02F01T01 454:L98P01 457:G88S10 458:I59L40 459:A97V01 460:R92K02Q02H01 461:A37T21N21S10M06 462:E98Q01 463:L97I02 464:F96W03 465:L97I02 466:F81L16I02 467:F87L09V02 468:T97A01 469:T72A21S05 470:I85L05V04M04 473:N73A23T01K01 475:S86T08N02 476:L51V35I 10F01 477:A34S23E20G07D05R02T02K02 478:S83T09G03P02 479:P87S05L02N02 480:V50C23M 11K08S02E01L01 481:A62P29D05 482:P93L03S01 483:E51K20G20D04A01S01 484:D71A17T05E03 485:I73L26

486:D72S25N01 487:L88F05I04 488:T59Q23S11K02R01 490:Q29A24K23R10M03E02T02I01

491:E59V28I05N01R01K01A01 492:S67N11C08V06I02F01 494:L39V29F20I08A01 495:G65F23A05S01T01 496:K49N32R15T02 497:I41V29L22M03P01 498:P98A01 499:P87Q07R03S01

500:T30A24V16P08E04D03S03I03L02K01N01 501:Y63F36 502:Q88K08E01R01 503:I57L38V03 504:C30R27Q24S11H02G01L01N01 505:F75V19A02L02 506:L67R19V04W03Q02I01H01 507:P73A18S06

508:R81T05H04A03-01C01

(xx) N118

1:-97M02 2:-98A01 3:-97L02 4:M97-02 5:L45E37D07A03-02G01 6:A40L38W04D03T02V02F02G02M01- 01101 7:S53G27A07T02L02V02-01E01R01 8:G87W03-02D01E01V01Y01 9:L44A37V05M04-02C01I01T01 11:L49F17V13I05A03G02T02W02-01 12:L45T42S05-01G01V01 13:V43I26L21G02-01M01A01F01

14:A38F33L14T05V02-01I01 15:L82V05I04M03-01 16:L43A28V11G04T03-02F02E01I01

18:A40L29I 15T04V03F02-02S01 19:C67F10Y07L06-03S01A01 20:L80I07V04-02F02A01 21:S64T23- 02L02I01V01 22:C46V33I08L03T02F01-01A01G01 23:-98L01 24:L51M41H02I01V01

25:V41L35A08I08F02M01 26:L61I28V04F03 27:M40L35I07V07F03Y02 28:S68I20W02L02A01F01-01 29:V44A33T07L04S03E02I02F01 30:W90K05R01-01 31:R42K40Q08N04W01 32:Q52R24K16W02-01T01 33:R53M12I08T06-06L03K02Q02V02A01 36:-98G01 38:K44S16N11H06Q05Y04R04L02-01

39:L30K26R11S06F03I03Q03H03V03G02P02 40:R25G22W17K12S05L03A02E02Q02Y01P01 41:-98L01 42:G85R05S02E02A01K01 43:-98G01 44:K76R12N06S01 45:L90M06F02 50:T92M02I02 51:P97A02 52:L79I20 54:F72L23Y02 55:I61L33F03 58:Y46L37F10V02I01 59:L96F01M01 60:Q95H01E01

61:L55V28I14M01 62:N42R21K19D10S03G01 63:T68R06S06I04P04A01K01N01V01

64:E37D21K11G 10S09Q04T01R01 65:Q36A19E18D08K07N04G02H01S01 66:M47T32I06L05V03P02 67:Y46F25L16V04S02C01P01 68:N32K25Q24D07S06T01 69:S94C02P01T01 70:L65F26I07

71:M69L18T06E02I01 72:K82E07A05Q03 73:L56I37M04 74:S46R33G06Q05K04H02 75:E76K15D03Q02 76:K46R40Q04H03C01I01 79:P87S08 81:F92Y07 83:V57I35L06 84Ύ49Η48 85:L64M 18F15

87:P72S11T08L04 88:-97W02 89:R90Q03K02S02H01 90:R51P45Q02 91:V71I28 92:V90L04I04

93:V90I06M01F01 95:C88Y05W02S01 96:G96D01S01 97:H46Y44Q06 98:E48D40Q07R01 99:A93V03T02S01 100:V91I04L03 101:K97R02 105:V82I 11L04 106:D97G01 107:Q79K08H05R04N01 108:A92G06 109:E77D21 110:E74D20Q01A01N01 112:S91G03A02C01 113:G97D01 115:G90A04T02 116:E74T07K07A04Q02G01 117:Q48M20L19I04N03K01V01 118:A69P24V01S01T01 119:T66S26V02I01 120:F46L20I 18V08Y04 121:D55E30N09Q01 122:W40R40K06T05Q04S01 123:L44N26I08T08V03Y02F01S01A01 124:F94T02V01 125:K48Q39N04E02H02R01 127:Y66H23F08 129:V88L06I03E01 130:A63V22T07I02G01S01

131:F66L26M03T01 132:S61A34T02 133:N86S09T01 134:G94W04 135:E95D04 136:R95E02

137:W49A45S03 138:K77R22 139:Q70I 19P02V02H01K01S01 140:L96M02 142:R94H03 144:S94T02A01 145:I50L45T01V01 146:T65A21S06I01M01K01 147:T64I 19V13A02 149:R94K04 150:D67N28S01 151:F97L01 153:M53V43F02L01 155:K98R01 156:R84K11C01 157:G48S46T02 158:I91V05-01L01 159:E97-01 161:R96- 01K01 163:Q89K03L03 164:E96D02 166:A95T02I01 167:G63Q26S04A02 168:F62Y26C08

170:L42I37V16M02 171:E80K07Q06D02G01 172:E42A40M04S04T03K01V01 173:F47L44I07

174:R77Q11H04K02S01 175:K47G29D06S05E04A02N02T01 176:T89Y03V02S01

177:K46R25N08H05Q04C03G03 178:G86E10A01 179:A66K11L05T05S04E02N02Q02

180:P57F27N04L02S02 181:I67F25V03L01T01 182:D85E11N02 183:P96L02 184:T93S02A01I01

185:F73Y11L02N02I02K01S01V01 186:F56Y26L07I06P02 187:L92I03M02V01 188:S94V02

189:R75K08Q06C05H02 190:T69A24S04C02 191:V95T02 192:S95A01C01T01 194:V91I08 195:I96M02 196:S70C24N05 198:I71V27 199:V96A01L01 202:D53S23N11K04E03Q01 205:D88E09N01

207:E90D02Q02S01K01 208:D93N06 209:K88Q05E03 210:E58Q22K05T05D02C02R02 212:L84Q11H02 213:S62K13A08N05T03E02R01Y01 214:L97M01 215:L86M12

216:R51Q17K04E04H03G03D03N02S02Y02A01 217:M80L09I04K02V01-01 218:M54I34F04T02V02 219:N42L36T05G04Q03H02M02D01 220:E40G38N06Q04D01K01R01S01A01

221:S70T07I06M04V03F02L01A01 222:F89N06K02L01 223:Q41I 19R18K04V04L02T02W02E02

224:F51E42L04D01 225:T42M39A06I06L03V01 226:S51A46N01 227:T71S21K02I01M01

228:S42P40A06T04G01V01 229:W49T35M07L02R01S01 230:G57A28S10T02 231:Q97L01 232:L88F06I03 233:Y88F03C02Q02L01 234:D46E45N06 235:M89I06F01V01 236:F60Y33L02I01

237:S39Y24P14H06A03V03W03E02 238:S55G26C04R02P02N01T01A01D01 239:V56I30F06L06

240:M86L11 241:K59Q27N05R04D02 242:Y55H41F01 243:L77F15I05V01 246:P71R24S02G01 247:Q51H48 248:Q49N25H07T06K06R01S01 249:Q44R28K17H04E02Y01N01 250:A43I37V08L07

251:F46Y40I05L02V02D01P01 252:K53Y20N10H04D03R02Q01T01A01 253:E36L35I08D07N05H02V01 254:L56I23M07V04T03S01Y01F01 255:E42Q37K08A02N02R01S01G01 256:G43E26D14K08A01R01V01 257:L87M08I01V01 258:E48K32R09N03H02L01I01 259:D75N04E03K03V03A03L03 260:F95Y03

261:I84M07V06 262:A66T11I06V05E02L02 263:K51S19E16Q05R04 264:K55R44 265:V93I04A01

266:K48E41R05Q02 267:Q36I22H09K08M05A04E04R02L02V01T01 268:N95H03 269:Q67E25K02H01R01 270:R37A28E19S07K02Q01C01D01 271:T77S22 272:L87F12 274:P91S03L02 275:N68Q16S08K01

276:S60N26F05A03C02H01 278:-97A02 279:R97Q02 280:D86N11 281:F94Y04 284:S51C44A01Y01 287:I96V01 288:R41K35Q17H04E01 289:M96I02 290:Q48E22H19Y03R02K01 291:E45Q32K20 292:E80D18 293:K73Q14E06-02R01 294:K38N24D09Q09G05S05-02E02 295:N90D04K02H01 296:P93S02V01

297:N53H15S11Q04A03D02T02L02K01Y01 298:T63S34 301:N40Y29H17T03F03S02I01

302:M46L34T05I04V02Y01F01R01 303:K84R07E03Q01T01 305:L96I02 306:V77E10L05I02T01

307:L64M27I01A01E01T01 308:T96S02 309:T79S05I05V04A03 310:L90F02I02V02 311:N86S08Q01G01H01 312:L95V02I01 314:F91I03L01V01 315:A94G05 317:T93S05 319:T97S01 320:V92T03I02 321:S97T01 322:T48S48 324:L94M04 325:R93K03H01 326:Y91H04F02 327:G94S02A01 328:F86L08I03M01

330:L86F06I04V01 331:L94M03F01 332:M83L11I01V01 333:K95I02R02 334:H60Y37N01

336:E56D37H02K01 337:V88I 11 338:E72Q22A02 339:A79E17G01 340:K98R01 341:V61I27L06M04 342:H86Q04Y04R01 343:E88Q07K01 345:I97V01 346:D80N15E01 347:R63Q28H03S01 349:I96V03 351:R34K28P17Q07H05T03S01 352:N71H23D02S01 353:R95Q01H01 354:Q42I22S13V08T04L03H02A01 355:P97A01 356:K37S21A14N10Q08R02M02T02 357:F39V22I 16Y07M06S02A02T01 358:E76D16N03K01 360:R88H06K04 361:A34V17S15M 15L05R02N02G01P01T01 362:K75R10Q08N01S01 365:Y97F02

366:T91M06V01 367:D47E45N04Q02 371:H94N04 373:I92V03C01T01 376:F62L23V06C02M01

377:G34T24S19A11I03V02C02L01 378:D83N15 379:I41M26L14V11F06 380:I51V29A09L07 382:M77L18V02 383:G80N08S08D02 384:V47L40I09 385:P56A40S02 386:H53R46 387:R48N17T08K05S04A04M04I01L01 388:V88T04I04 389:T61I31N03M01K01V01 390:K51R40C04E01Q01 391:D93N04 392:T96I02

393:K38H22Q17E10T06N01 394:F98L01 395:R97Q02 396:G61D30E04N02 397:Y51F47 398:L54F25T13I03 399:L67I32 401:K96Q03 402:G93D06 403:T95M04 404:E56D33N05T02 405:V92I06 406:F72Y22I02C01 407:P93A04T01 408:L41M40I10V06 409:L91I06 410:G80S13C04 411:S87T09A02 412:V88A06L05 413:L95M02H01 414:R43K26H15T08Q02 415:D97E02 416:P89T02R02S01A01Y01

417:K76T08R03N02E02S02A01Q01 418:F47Y32M06Q04H03K03 420:S48R21K16A05P04E01

421:N42Y19S13D05T05K04R03C02H02 423:D23Q21E21N08K08R06G03Y02F01S01

424:D44A28S05T05E03K03N02V02G01I01 426:N64Y21H06D05 428:Q62E13G12N04K03S01 429:H85N13 433:E75D20A02 434:K44N25Q21E03R01D01S01 436:Q49R34H05C05S02G01 437:F93L06 438:K95R02 439:K95S01R01 440:N63S33I01 441:D67E24A03N02 442:A96G03 444:V78M12L05I03 445:P93A05V01 447:S97A01 448:I41S38T06A04L04V03 450:K98R01 452:Y35I28V15N08F06A01M01L01 454:L50F42V05P01 456:E92D04K01 457:G54A31S10M02N01 458:L79M20 459:A97T01 460:R92K04L01 465:L95I03

466:F67Y28L01I01 467:F51L46V02 469:T58S25N09I03A01F01 470:I92V04L01 471:L75M22I02

473:N78S10R08H02 474:F98L01 475:R39S29T08H07C06Q04K02 476:L51F48 477:K60R23Q07H03T02E02 478:S77P16F04 479:P50L37S04E02T02Q01 480:Q38V37K06L04T03I02M01S01

481:P37A20S17D05L05K04Q02H02E01 482:P83L06F03R02T01 483:Q35E21A19K13T04N01

484:D82E13A02N01 485:I88L04D02S01V01 486:D88N06Y02 487:V43I38L08T04E04P01

488:S55T32A07K01N01 489:P95H03 490:K69Q12R08L04E02T01

491:H24I18L14E09M08P08V08A02Y01F01S01 492:V41S40L07N03T02F01 494:F95L02

495:A54G28T08L02I01S01V01 496:N44T41R08S02K01 497:I84V06L03Y02M01 498:P90I04L02V01 499:P61R31I03T01L01 500:N33T27S12F09K03P03R02I01V01D01E01 501:Y96F02

502:T47Q20E20K08H01R01 503:M45L43I06V02F01 504:S57C39R01 505:F56L26V07A04I02M01

506:L40V29I12Q08M05 507:P72A20S04 508:R91I04L01H01

(xxi) N133

4:M98-01 5:D85E03A02V02Y02-01 6:L47P43A04S03-01 7:-96S03 8:-96V01G01 9:-96V02 11:-96T03 12:V39F32A10L04T03G03I02-01S01 13:V63I15L10T05M01 14:V67I11F07A05L05G01 16:V83G09L04A01 18:L68I22F05V01 19:C66S09G08T06V02I02L01 20:L91V03I02 21:S91C03T01-01 22:C79F09S05I03 24:L89W04M02V01 25:L68I22F04V03 26:L87F08P01 27:L77F16I03V01 28:S82F12L03

29:L87F02A02I02R02V01 30:W94R03L02 31:R45K32N19 32:Q84K04R03G03 33:S65N12R12K02H02G02T01 38:S59Y15H15A02T02R01F01N01 39:G58A17E07R06Q03S02V01 40:R53K42G02 41:-98L01 42:G82R15 43:- 98G01 44:K86R05N04T01 47:P97S02 50:T92I02M01 52:L91F08 54:I82V07L06F02 55:I70V14L13F01 58:I75F10L04M02V02Y01S01 59:L91F05H01 60:Q96L01 61:I49L38V09M01 62:D73N22G03

63:V48I16T13L06M05F04A01R01S01 64:K94R01N01 65:N51D47 66:I83V07M02L02F02

67:S74R04T04G03N03C03P02Q01 68:K80Q12E01R01G01N01 69:S96C03 70:L74F13I09M01

71:S40T39R05C02N02K02G01H01 72:N56K21M11S03D02V01 73:L65F33 74:S73A24 75:K83E14

76:V57D11T07E06A06K02S02I01L01R01 79:P98S01 81:F97Y02 83154V44 84Ύ96Η02 85:F61L35V01 87:M62L12S08T07R05Q01 89:K76Q09E04R04N03 90:P93R06 91:T71I09A07V05M03L01S01 93:V96I03 94:L92V04M02I01 95:H87Y10C01 98:E89K04D02N01 99:A94V02T02 100:V86I07L04M01 102:E96Q03 103:A94V03 104:L97F01 105:I78V16D03 106:D97G01 107:H34L32R13Q09N04M01 108:G88S07A03 109:E94D04 110:E88V04D02K02 112:S80A19 113:G91A04E02D01 114:R97K02 115:G86S03N02T01V01A01 116:S55R11H08N05I04T03D02A02Q01L01V01 117:F67L12S06I04V02M02H01Y01 118:P95S02 119:V58I17L12M08F01A01 120:A35I14F13V09L09S08T03N01G01 121:E55D30Q06S02K02A02

122:K47R41N04W02 123:I33V23A18T08L05S02M02Y01F01N01 124:N56T15S09A03F03K03V01I01G01R01 125:K58Q19R08N07E01 126:G89D02E02R01 127:L53H16F13Y05K02N01A01Q01M01 129:I78V16L04 130:V45I37L07A03G02F01 131:F89S04L03A01V01 132:S97T02 133:N84S04H03V02T01K01Q01

134:G98A01 135:K43E25N20T04S02R01 136:R45T20K13I08V04L02Q01N01S01

139:E66Q22D03A02H01N01 140:T35I33M21L08 141:R98K01 142:R94H02V01 144:S82T13C01A01 145:L92V04I03 146:M77T15L02N02 147:T76V20I02 150:N91S04D01 151:F56M22L20 156:R77K19S01 157:S64T25N08D01 158:I94L02V01 160:D79E10N03H03S02 161:R91K02C02H01 162:V69I30 164:E95Q03 166:A97V01 167:R44L20Q14C06H06S04K02 168:C85Y07W02H01 170:V93M02L02 171:E92K04Q01D01 172:E75A22 173:L97F01 174:R74K24 175:K95E02 176:T97S01 177:N75K20 178:A49G47S01

179:S82L10A01Q01 180:P95L02S01 181:C96F02 182:D96N02 184:T87S08Q01 185:F89L03S03Y01 186:I70L24V01F01 187:L96I01 188:G70S15A05T04F02 189:C90A04Y03S01 190:A85V13 191:P95S02V01 192:C94S04 196:C93S05 197:S96A01F01 198:I78V20 199:I81V17 201:Q78H13R04G01K01

202:N74K13D03H03S02T01 203:R94H04 205:D83E15 207:K50T14S13N08R03D03E02

209:Q55E17K16P05R01N01 210:N23D20K18T10E09Q04H03R02I01V01S01 211:F91L06V01

212:L87Q06I02H01V01 213:N44T31K07S04D03G01H01I01 214:L79F12I06M01 215:M61L18I14A02V02 216:E53K27G07N06H01D01R01 217:K47Y19R12L05I03N03H02T01M01V01 218:F48L36V07I05

219:N73H15D04E01L01T01 220:E92D03R01 221:N86I03S02C02D01 222:F25V22L18I12A07T06M02S01 223:R40K30E14Q02S02L02N02T02 224:I87L07T01N01V01 225:L70V09F05S04A03M03I01

226:S79N13G03T01A01 227:S75T22A01 228:P88S06L01 229:W95G02I01

230:I60M13L09V07A02T01C01G01 231:Q94E04 232:V49L29I16F02 233:C67Y26F03L01 234:N94S04 235:N36A26S10I09T08M02F02L01 236:F91Y02L02V01I01 237:P97S02

238:A29116V13S11F11L09P04M01T01Y01 239:L82I08F07V01 240:I58L20-10M07V01

241:D72H18R02Y02N01 242:Y87C04V02F02H02 243:L50F31C14Y01 245:G98W01

246:S71T10I05R03P02C01K01N01 247:H94Y03 248:N61K15H12R05T01S01

249:K59T16E05V04I03Q02R02D01A01N01 250:L47I16F15V15A01Y01M01

251:L40F37I08Y02A02T02V01S01H01 252:K83N05E04Q02T01 253:N92I02D01H01V01

254:F27I26V14M08Y07S04A02H02T01L01 255:A49T14N11D08I03E02S02F01K01Q01V01Y01

256:Y42E12F12L08D06N04W02C01H01K01A01G01 257:I27Q21V15L15T08M05F02

258:K69R13I02Q02E02F02H02N01 259:S46N21K18D03H03E02Q01T01 260:Y65F33 261:I53V21L13F10C01 262:L78M08S04R03F02 263:E85K08A02G01 264:K85R07E04Q02 265:I48V41T07A01

266:K84R04Q02E01I01M01V01 267:E93R02K01 269:Q88E05K02A01 270:E73A16K06Q01D01 271:S88T09 272195M03 273:D96N03 274:I43V24L09M08P04F04H01 275:N68T11D07S06A03H02 276:N94S02D01I01 279:R89Q09 281:F96Y02 282:I97V01 284:C58Y39H01 285:F87Y10L01 287:I94M03 288:K91R04Q03 289:M82R05L03I02G02Q02W01 290:E77K10R03G02Q01S01 291:Q69K27E02 292:E88A04-01D01V01K01 293:K80N12-01S01D01 294:H68Q08D07N05G03Y02C01-01 295:N86I04S03E01K01

296:Q47K24P14E06H02N01L01 297:Q60E11H09K08N02P02S01 298:S71L14T07M03A01

299:E85K03Q03I02A01D01V01 300:F88Y09N01 301:T87S04N04I02 302:I29M24L21F06T05Y04V04C01H01 303:E75D19H02G01 304:N80S10H06A01 306:I30V29A13T08L07M05E02K01S01

307:I29A18T18V08N06G04S03F03M02Y02C02 308:T86S04A03L02M01I01 309:V59I21A14T02L01 310:S25W18T16A09N07F06L06V04G01I01M01 311:D97N02 312:L73V15M07I02 313:F94L02V01I01 314:G44S16A15V10F03T03I02D02 315:A97G02 317:T92I03S03 318:E93Q02D01 319:T96S02

320:T92M02L01V01 321:S97G01 322:T86S08I02L01 324:L85M 12101 325:R88K10 326:Y92F07

327:G63A29S06 330:L94M01V01I01 332:L81M16I01 334:H78Y20 335:P94T04 336:E78H11D06Q01 337:V84I15 338:T81A07S06Q01 339:A93E02V01 341:V86I07A05 342:Q91R04H03 343:E92K04A01 346:D61E26H04N02A01Q01 347:R64H24Q04C03N03 349:I68V31 351:R92K06 352:H70N20D06E02 353:R97Q01 354:S93R02T01 355:P97A01V01 356:C95S03 358:Q92K03E02 360:R93K06

361:S81N07T03G03K01 362:H46R32S10N04C03K01 366:T87M12 367:D88N08E01 369:V73M16L04T04 370:V58I27L13M01 373:I72V27 376:Y80F18 377:I92V03L01S01T01 378:D89N09 379:L92I03F01M01 380:V44I33L13A03G02 382:T53N32I05S02L01V01M01 383:N54S32G08P02I01 384:L74V21I01M01 385:P95L02V01 386:H93R06 387:A83E04T02S02K02M01V01 388:V83T08A08 389:T93A02N02

390:C44Q26R18H03S03T03 391:D92N07 392:I56V33T07L01M01 393:K78Q08R05E04H01

396:N68E17G07D04Q02 397:Y98F01 398:L66F17I05V04H03T02 401:K97N01

404:T62A07N07D06S03E02H02G01Q01I01 405:I70V24L03 406:L52I31M09V03F01 407:T71P10A06I06V03 408:S88L05C02D02H01 410:T78S20 412:V96A01 414:H77Y14R03N01K01 415:D94N03S01

416:D54S17N12E08G02A01K01P01 417:K91Q03T02R01N01 418:E94Q01A01G01 420:P92S04L01K01 421:N91D02H02K01R01 423:E77K10D06G02N01 424:V23K21T14Q11M11I10R05E01 426:D97N02 428:G86A05R03H01S01 433:E65K18A05D05G04 434:S57N28G04K03R02 436:N85K12S02 438:K94R05 440:S97T01N01 441:D91N05E02 442Ύ90Η06Α01Ν01 444:M87L03V03I02F01 445:P68A29T01

448:A65T28I04S01 450:K98R01 452:I45V20M18A11S01N01 454:V54A34L06I03M01 457:G81S09A09 460:R95K01 463:L94M02V01 465:L97I02 466:F75L12I10V01 467:L95F03 468:T95V04 469:T71S16N05A03 470:I97V01 471:L98V01 473:N57K22H17Q01 475:T52N26K16H02 477:K95Q01E01 478:S59P39

479:L65V22P03Q03E02 480:V85I05T02L01D01A01 481:D82H08N03E02P01 482:P85L07T04I01 483:K93E04 484:D85N08H02E01 485:I73L23V02 486:D88N09E02 487:T70I18V03P02M01A01 488:T93A01I01S01 489:P90A05S03 490:V60116L06A04T04K01E01F01M01S01

491:V32A25S06L06T05F04N04H04D02Q02E01Y01 492:N58S20K12T04R01I01 493:G90T03A03S02 494:F60L25I09V02 495:G32A29V16S07L05I04T02N01 496:S69H10R06N03T02K02A02C01L01

497:V64L19I11M02A01 498:P96L02 499:P94H02R02 500:S36F23P14L07T03N03E02H02A02K01V01 501:Y86F12 502:Q63E20K13 503:L77I13V04M03 504:C91S04R02Y01 505:F97L01 506:I86V08L02T01 508:V75L06I05S04R03A02M01

(xxii) N134

1:-97M02 2:-97A02 3:-97L02 4:M96-01 5:A51E23D09S08G03T02 6:A43L24V13P10F02R02 7:L82W09S03- 01101 8:G87E05-02S02 9:-64L14V09l07A02F01 11:I49T31V10P03A02-01 12:T87S07V03W01

13:V38L26I17T08P03F02A01G01 14:A75V11I03-02L02T02F01 15:L96F02I01 16:L71V23I02T01M01 17:- 98L01 18:V65I 13T07G03A03L03F01 19:W62C25S04F03L02A01 20:V63M20L05A04F02I02

21:A50V14T14L08S07I02 22:T42C21F17V05I04A03L03 23:-97L02 24:L98F01 25:L63I13V10M07S03 26:L55F36I02V02C02 27:I48L33V13A03F01 28:S76F16L02W02Q01 29:I47V31L14A03M03 30:W97I01 31:K65R20N06T05S01W01 32:Q53K23H16R03E02N01 33:I47G 14V11S10R03M03L02N01D01K01 36:- 97G02 37Ύ44-36Η17Κ01 38:S65H12R07T04G03F03Y01 39:S60K24T05R04G01N01Y01

40:W61R21G08K05A01 41:-90L07A01 42:-63G29R04A01 43:-96G03 44:K41N31R22Q03L01 45:L98F01 50:F62T27I03A02P02 54:I89F05L02V01 55:I73L10V08F06 58:L58I23V10M06 59:L52F35M 10 60:Q96N02 61:L85V06F03I02M01 62:D57N23E17 63:L62I 15F10T04W01H01P01S01 64:K92W02N01R01S01

65:N55D41A01 66:I66V12L09M07F02P01 67:P88A03F02T01 68:K65A20T06S03E01M01 69:S94T04F01 70:F66L31Y01 71:T53S32A03G02M02D01C01H01 72:K49R44E02Q02 73:L97M02 74:A94S05 75:E55K35Q08 76:R58K17E16Q07 77:Y66F32 79:P95S04 80:V90I08 81:F68Y30C01 82:T97S02 83:L84V13I02 84:Y83H12R02 85:L72F10V09I06M01 86:G98A01 87:S74P10T09L01W01 88:-97W02 89:R49Q36W03H02N02T02S01 90:R74P18T02I02L01 91:V44T29I17F03M02A01 93:V98I01 94:L81V10M06 95:H93Y03C03

98:K61E20N06D06Q03 99:A79I07V07P03 100:V95L02M01 101:K85R14 102:E97D02 103:A51V45M01 105:L65I28V03C02 106:D66N19Q05T03G02 107:H35Q27Y26K03L02-01R01 108:K57G34R04A03

109:N54D38E03V02 110:E78I08D07N04 111:F93L06 112:S65L19M07G03A02 113:G86E07D02Y01N01 115:G91A07 116:E41D20N10P07H05A03R03K02I01Q01 117:I60L11V10N06F05M03T01Y01

118:P86F06A02H02Y02 119:A41I33V18G03M01 120:F72I20L02M02Y02 121:Q37D19E19H11R07S02 122:D27A24E21V11L03N02R02K01M01F01 123:H43T19Y16I05F04A03V03N02

124:K45Q20R06L06I03T03V03F02N02E01A01H01 125:-62K29R06G01 126:D42G36N14E01Q01S01 127:K31R20Y18Q13H04N04S03L02 129:I78V12L08E01 130:I57V16T10L09F03S01 131:F96N01V01 132:N60S38 133:N77H13R03S02Q01 134:G96S02A01 135:P57E33D02N02R01 136:T57R27G05K04S03W01 137:W98S01 138:K81R13Q04 139:D58Q31E03L02V02H01T01 140:T36M 19I 19V15L06H01N01 141:R98M01 142:R96G01 143:F85L10S02A01 144:S91T05A02 145:L98R01 146:T48M32S15R01 147:T69I20V05A02M01 149:R97A01 150:D54N43T01 151:F46Y43L07W02 153:M98T01 154:G98D01 155:K98N01

156:R44Q42E05K03L01H01 157:G52S39T03A02R02 158:N62I24L09V01M01 159:E98S01

160:E58A14Q13S07D03I01 162:I74V24M01 164:R55E36K06 165:E98I01 166:A82I07V04S03T01

167:Q39H34P13R08G03 168:F65C20Y07L03H02 170:V48L46M02I01 171:E81Q06D05G03K01

172:E55A39V03 173:L92F06 174:R82K09Q02S02T01 175:K85G06N03Q02E01 176:T94S02M01

177:Q43K22E17N07H03R03 178:G76A19S03 179:Q95R02K01 180:P98F01 181:F87T04N03L02V02 182:D95N03 184:T93A03V02 185:F95L02V01 186:L41I28V24T04 187:L51I40V05F01 188:G73S19A05 189:C67F16G08Y03L02 190:A91G06T01 191:P91V03S02T02 192:C73Y10F09S03L02 194:V96I02

196:A41C36S19F02 197:D61S37K01 198:I95T02V02 199:L94V05 200:F98L01 201:H35R30N27G03 202:K43E24R12D11Q03H01S01N01 203:R68H31 204:F92L02V02A01S01 205:D64Q10N09H06K05P02 207:N44K18D11E07T06S05Q02M01 208:D94N04 209:K55E36Q03R03D01 210:T51K39Q03E03M01 211:F38C27G15A07L07I02S01 212:L89Q04H02R01V01 213:R62Y12S08T05H03N03Q01 214:L85I07M06 215:M71L15Q10I02 216:S34N15R11Y10H09D07K03G03T02M01 217:L91I03M03A01 218:F59L35I02Y02 220:E89K07A02 221:N92D04T01 222:F93L02S02 223:Y48R13H11Q10K06N04S03

224:L77Q10R06I02K01F01 225170111V08F07 226:S76N20T03 227:T62S29K07

228:P79G05R03V02F02L02S02 229:W98M01 230:L43I35N06C05G03A02T01 231:Q98L01 232:L72I10M08V04A02F02 233Ύ96Η02 235:N48L22F10I10Y03S03M01 236:F66W19L08Y02V01

237:P58S34A05G02 238:S38D16A08K08T07G06N05Q02R01I01W01 239:Y45L23F21I04C03

240:L55I24M 10R07 241:R27H25K20Q08V06D03Y02N02C01 242Ύ76Η18Ρ02 243:L89M06F01

246:S58E17K10P04N03R02T01 248:R71K17Q03H03W03I01 249:K70A10E05R04Q03S02T01

250:V37F23L21I 16M01 251:M31F17S16I 15L15A01N01 252:K89R03A02E01S01 253:N79R18I01

254:V65L15I07A04F02T01N01 255:S50E13A08K06Q05N04Y04D02T02L01 256:E74D14N04K03G01 257:I55V23L16A02C01 258:K89R05H02 259:D27E19N14Q10A07Y05S04C03K02V01R01 260:Y61F37 261:I34A30T20V13 262:L72S17A04F02M01R01 263:E85A10D01 264:R62K25G03Q03E01M01

265:V78A15I02T02L01 266:K96A02 267:E81D09K02M02Q02R01 268:H97N01 269:Q65L18H12E02 270:Q34E33K24R02T01 271:S77T13I03V02L01 272197P01 273:D83E09N03K02A01

274:P73H07S05L05A03Q02I01 275:N67S20A04E01G01D01K01 276:C59N32S04Q02 277:P95L02 278:- 97A02 279:R82Q16 280:D94G03N01 281:F41Y33V12L12 282:T55I38L04 284:C82T09S06

285:L53F28M09Y08 287:S27I22M13V13L09A03T02D01H01R01 288:E59K32R04Q03 289:M89L06I03 290:E75Q16A03R02H01 291:K61Q31E06 292:E92D04G01 293:K86R10Q01N01

294:H55Q14Y10D06N05K03L01 295:S51N39K03T02G01R01 296:P37A26G06K06T06S06Q03L02E01 297:E55D11Q11K10N02M02Y02A01 298:P49S42R04I01 299:E33M 15L14G 13V10W08A01Q01

300:Y51F45H01 301:T55D18N12H10 302:L63M24V03Y02F02S02 303:E63D33Q01 304:N82G 11S03D01E01 305:I57L37V04 306:A54T13S12V11I04K01L01 307:V63M 11T11A08I03N01 308:T77C16V02S01

309:V44G30L15T03A03I02 310:A65S20V05L04F02 311:D73N25 312:L96M02 313:F86L13

314:F65S16T06A06V03 317:T96V01 318:E96V02 320:T97V02 321:S92T05N02 322:T69S20A04I02L01N01 325:R92S04K02 326:Y89F08L02 327:G93A04S01 328:L96F03 330:I62L31V04 331:L89I 10 332:M74L23 334Ύ64Η35 336:E96H01K01 337:V56I43 338:E75Q24 339:E66A28S01D01 340:K97R01 341:L62V24I 12 342:H96Q02 343:E94K03 345:I96L02 346:D93N03G01 347:R92S03K01Q01 349:I95V03L01

351:P62R23H08C02S01 352:S52N27T07H05D03E01 353:R83Q16 354:I57S14V11L03M03P03R03K01 356:A55S27C15 357:I49M27V17L02F01 358:K88R03E03Q02 360:R76K23 361:L54M 15Q15V04A03I03S02 362:E46K21D20Q07N02 363:M84L15 366:M58T28L11V01 367:D84E15 370:V75L18I05 371:H97N02 373:I89V10 374:Q98L01 376:F77Y21 377:I95T01L01 378:D39N33T23A01H01 379:L94I05 380:V52L31I14F01 382:S83L11M02F01 383:N89S07G02 384:L94M02V02 385:P85L06F02S02N01 386:H96R03

387:E57A29T04V02K01I01L01M01 388:A60V34M02T01 389:T70N13V09I03A02 390:R53Q41K03H01 392:T87I 10V01 393:K22V22M21Q09I08H08T03E01 394:F92L07 395:R82Q17 396:G65Q27D02E01K01 397:Y96F02 398:V59L11I 10F08T07 399:I95L04 403:T97A02 404:V51T33I04L03N03 405:V70I25L03 406:I51F17L17V09Y03 408:T62L34M01 410:D59S35T02Y01 411:S90P09 412:V52L38I08 413:L95M04 414:Y62F17L07H06C02R01M01 416:S31N24C13K12D06R04P03Q02 417:Q60K36 418:E94Q03A01 419:F98W01 420:P87S04A03K03T01 421:D47N38E12K01 422:P97A01 423:E82D10Q02G01Y01

424:K70Q16T05E04R02 426:K56D36N05M01 428:E62G26Q07N02 429:H98N01 432:N55D43

433:E68K29G01 434:N79S09D03E02H02K02 436:K65S24C05N02R01 437:F95L02V01 438:K80R17Q01 439Ύ62Κ37 440:S77T17N04 441:D92E05K02 442:Y76H14C03A03F02 444:K62V19M 13103 445:P59A39V01 448:A63I 14L13T06M01 452:V62A27S04I02M01L01 454:V72L16A10 457:G87S12 460:R94K02Q01 461:M95V04463:L93V04I02 465:L98P01 466:F71L28 467:L79F18I01 468:T48S33A13C03I01

469:A54T37S05I02 470:I91V03L03T01 473:H62N33K04 475:N61T19S11V06 476:L97F01 477:K97R01 478:S54P43T01 479:L79V14P03M01 480:V79G13I04E01K01 481:D71E26S02 482:P93T02Q01R01 483:K77N08E06R04M02 484:D71E27 485:I84L15 486:D76E09S05N03R01V01 487:L58I20T14V03F01 488:S45K36T08N04R02D02 489:P91N05T01 490:I58V11N07L04A04E03M03S02G01T01

491:T36A19V18H09N04S04Y01F01R01 492:I48T19V19N06S05 494:F80L15I03

495:G47A18I12T06L05V04F02N01S01 496:N35S23K20C11R07T01 497:I72V17L04M03 498:P97R01 499:P89R04Q03S01 500:H36P20R16S07E05Y04I03D02K01 501:Y84F15 502:K83Q13R02 503:L97F02 504:C94R03S01 505:V50L28F18A01 506:I71L21V04T01 508:R93H04C01

(xxiii) N140

1:-94M05 2:-94A05 3:-94L05 4:M88-11 5:E90-04D04L01 6:L68A11F07P05-04V02 7:L87S06-04P01 8:G91- 05S02E01 9:M54T16V14A07L04-01G01 10:-97W02 11:T95P03A01 12:T92S04A02G01 13:I85L07V04H02 14:F80L12I06R01 15:L98S01 16:L86V11M01Q01 17:-96L03 18:V84L07I04A01C01T01 19:C94L04N01 20:I87L05V03F02T01 21:S95A02C01L01 22:C93L03-01F01N01 23:-93L06 24:L84- 14101 25:L94F05 26180- 13F05A01 27:F82L11I05C01 28:A80S10L04T03F01R01 29:T66A20S07L04R01 30:W96C01Q01R01 31:R95- 02K01T01 32:S81K11R04N02T01 33:I60R24T07V03M02-01K01 34:-97A01S01 35:-98K01 36:-94G05 37:- 96K03 38:S92R05A01L01 39:Q81R14G03H01 40:K77R12T06S02N01 41:-91L08 42:E62G33-02K01Q01 43:- 91G08 44:K94R05 45:Q58E27L11M01P01 50:I65T23M05A02F02L01 51:T43A22P22S11V01

52:L76F17I04V01 54:I85L10V03F01 55:V70I15L11A03 57:N91S08 58:I58L23V13M02T02 59:L82F17 60:Q95H04 61:L82I16V01 62:N91D07R01 63:P74L13T11M01 64:W80K12R06M01 65:N86A04D03K03E02 66:L92P04I01M01V01 67:P83A05M03F02S02Y02L01 68:E82K11G03Q03 70:L85F06M04Y02I01

71:K84M06H03R03E02 72:K64E32M02T01 73:L97I01M01 75:K70E26Q02M01 76:K97E01N01 78:G98S01 79:P93S06 80:V94I05 82:T98K01 83:I70V30 84:H52Y41W02K01N01Q01S01 85:L96V02F01

87:P84S11L02Q02 88:-94W05 89:Q92K05R02 90:K87P06R04E01 91:V87I06A04M01 95:Y93C06

97:Y97C01S01 98:D83E16 99:V67A27I03T01 100:V97L02 102:E97D02 105:I80V20 106:D97N02

107:Q86H08N03R01 108:A70G30 109:D86E13 110:D66E16N11A03T02 115:G95A03S01

116:N53T22I06S05A04E02V02H01K01Q01 117:L90M05I04 118:P98A01 119:L91V05I03 120:L44I30F25 121:K67R10D07E06Q05L01T01 122:K91R08 123:L84I12F02V01 124:F90T06N02S01 125:Q75K16R04E03 126:G98D01 127:T87Y06L02A01K01S01 129:I95L02V02 130:V95L04 131:T87F06V03I01N01 133:N98S01 136:T86R10I01S01V01 138:K87R12 139:Q98E01 140:L98M01 144:A84T08S04I01V01 145:L97I01V01 146:T97A01L01 147:T98A01 150:D88N11 151:F98L01 155:K96R03 156:K92R07 157:S72G17T10 158:I98V01 159:E98R01 160:E88A04K03D02Q01 161:R97-02 166:A97T02 167:H67N10Q08R06G03C02S01 168:F91Y08 171:E95Q03D01 172:R91E05A03 173:I63L30F06 174:R76K18S04 175:N88K06E03D01 176:T98K01 177:H83K07Q03N02C01D01R01 178:E83G14A01R01 179:R60Q24K13E01H01 181:F85L14 182:N77D21R01 184:G66S17T11N03V01 185:N55S15F08I05K05G02V02E01H01L01R01 186:F90L08C01

188:V45I36S08A03T03L01M01 189:H91C08 190:A98S01 191:V98A01 192:S97A02 194:I87V12

198:I91V07T01 199:V74I25 202:D91E05Q03 205:D98E01 207:E97D01K01 210:K86S06Q03N02G01 212:L87I05R03V02Q01 213:T88D04S03A01I01N01 214:L98F01 215:I87L07V03M01 216:E58D25N12Q03 217:L77W14I04M03 218:L70I26M03 219:E45D42N12 220:E95A01D01K01Q01 221:N91T04I02Y02 222:N85F08S03D01E01 223:K67R18W05S02A01D01H01N01Q01 224:L91Y04F03I01 225:Q91L03V03M02 226:N68S21T03G02L02A01M01 227:S94R03A02 228:I75P11V08L02F01T01 229:Q85W11H02T01

230:T80G08A04I04P01V01 231:Q97H01L01 232:L92-02I02V02A01 233Ύ96-02Τ01 235:F92I05V02 236:F92I05L02 238:T68I08N06S06A04R04 239:V70I 16L13 240:M94L05 241:D63E36

242:Y76H10F05R04I01N01S01 243196103 246:P97C01G01 247:H98Y01 248:Q66K26H05N01

249:K73Q14T10L01R01 250:M54L33I 12 251:I81F11M04A01L01V01 252:K84E10A03G01Q01 253:N98S01 254:I36T33F18V10A01 255:E90G04D03H01K01 256:K81E05N04T04A02M01Q01 257:V76I 11L10A01F01 258:D77N10K08H02R01 259:Q61K22D12E02H01R01 261:T70I25A02V02 262:L57T18S13A04R03F01K01 263:E81D17Q01 264:I88R08Q02 265:I61V38 266:A57M14K10T07E03I02L01R01S01V01

267:E75A10M07R03K02D01 270:E51K45A01G01Q01 271:T87S12 272:L92F03W03R01

274:P93A03L01R01S01 275:T77S11N10G01 276:C91S08 278:-94A05 281:F95Y04 282:I95V04

284:A85C08S03V02 286:L91I08 287:N85I 13T01 289:M96I03 290:E96D01H01Q01 291:Q97E02 293:K98E01 294:G76Q10E07R05 295:N95K04 296:G47S24D12P08A04H02 297:H70D13N06Y03K02Q02L01R01 298:S92- 04T02A01 299:E73K15-04A01D01H01I01N01V01 301:T87N07H04 302:V72I 11T07M05Y03 303:E91D07G01 304:T83N10S06 306:S72T14V11I01R01 307:R88M08K01Q01 308:T93S06 309:T95V03A01 310:L97F02 311:D93N05E01 314:L75F24 318:G91E08 321:S98G01 322:I48T30N10V06L03M01 323:T95A03S01 325:R98I01 326:H54Y30F14N01 327:G80A16S03 328:L72I20F04V03 329:L92V05M01R01 330:I96V03 332:Q64H18L15M01 334:Y91H07F01 336:E90H04D03K01Q01 338:V73E13Q08A03T01 339:E98G01 340:K98G01 341:I60M23V16 342:Q87H 12 343:K84E08Q06 347:C53S21R20H04A01 349:I96V03

351:R95Q04 352:D83N08E04S02G01 354:S97R02 356:C74R17A04S03 358:A77S13E07L01 361:S94A04N01 362:Q88K07R03 363:M95L03I01 365:Y85F14 370:I51V48 371:H98R01 373:I95V04 376:F83Y16

377:I95L03V01 379:F86L08I04 380:L76V16I06 382:L74I08F06M05A01N01T01V01 383:N90G05S04 384:V88L11 386:H94R05 387:A58T32S05M03 389:I80T16L01M01V01 390:K66R32Q01 392:T90V05I04 393:K88H05E02Q02R01 394:F90L08I01 396:D80G 13Q03N02E01 398:F85T07I03L02Y01 400:P93S05R01 402:D84G13K01N01 404:M72T13L08I03V02 405:I94V05 406:F87l05L04-02 407:P93-06

408:M64L12T07V07-06A01 409193-06 410:S47T36-06N03R03C01H01 411:S72P21-06 412:V70I21- 06A01L01 413193-06 414:H83-06Q04K03Y02 415:D93-06 416:S82P07C03-02N02R02 417:K98R01 418:E92Q07 419:F96W03 420:P92K07 423:E98K01 424:K87Q06T04A01 426:D88N11 428:G96E03 432:N88D11 433:A82E13P03T01 434:N96D03 435:G98D01 436:T85S12A02 437:F98L01 438:K93R06 439:K95R04 440:S92N07 441:D98N01 442:Y85A07H04C01F01 444:M98L01 448:A84T13I01V01

452:I81V11M07 454:A85L07V05I01 461:M98I01 463162137 465:I83L14V02 467191F06I01V01

468:T96I02A01 469:A46S40T11V02 470:I95L04 473:N94K04S01 475:T92S05A01N01 476195F04

477:K96R03 478:P88S11 479:V81L11T04A02I01 480:V87K04E03I03M01 481:D97A01N01

482:H73R13P12L01 483:K92E07 484:D86N06E05A01 485:I97V02 487:I90L05T04 488:S82T15R01V01 490156I24E08V05A02F02 491:V66I28T02A01P01 492:S67T30G01R01 493:T52S35G08A02I01

494187F08A02M01 495:A77V13G08 496:N95S03H01 497:M70I 16V06L04F01T01 498:P98S01 499:R95Q04 500:P74S08D07H07L01 502:E84Q14D01 503:V86L11I02 504:S84C11G03A01 505:F94A04L01 I 506:L50V36I12C01 507:P98S01

(xxiv) N157

1:-95M04 2:-97A02 3:-96L03 4:M95-04 5:E80A06M04G03D02 6:L67P22F04A03 7:-96S03 8:-97G01 9:- 97A01V01 10:-98W01 11:S86T06G03 12:V66A11I08T05L04S01 13:L86I06V03F02 14:L96I01 15:L79F18V01 16:L90F04V04 17:-98L01 18:A65T18I09L03S01 19:L73V18C02F01I01 20:L84F11T02

21:T42V18L16I07M06S04A03 22:G91S02C02L01 23:-97L02 24:L68F30 25:L91V06F01 26:L82V12I02F01 27:L97F02 28:L75M08-07W03S02V01 29:V38A26F14-10L05T02I01 30:R72WllQ07K05-02 31:G84R10S02 32:H63Q14R07Y05K04C02P01 33:P86R03T03S02A01 36:-97G02 37:-98K01 38:K79N06T04R04A03 39:A61S15T10R04I01G01P01 40:H56R27Q06Y06 41:-97L02 42:G95-01R01S01 43:-97G02

44:H55R33N04C03 45:L97F02 50:R75W10H04T03A01S01 54:F61L32I03 55:L98F01 58:L82I 11V05 60:Q98H01 61:M83I08L07 62:D88N08K01 63:R85H07T02Q02 64:K40R36G 15N03Q01S01 65:G94A02E02 66:L84F13P01 67:L90V04F02 68:K69N24R02Q01S01 69:S96T02 70:F88I07L03 71:L52M23Q11I07R02K02 72:R39Q25K24A07L01 73:L70F19I07M01 74:R76Q17S04 75:E80D11K03Q02G01 76:K94Q03R01 77Ύ97Η02 79:D93P04 83:V91L05I01M01 84Ύ66Η32 87:P75S17Q02L01T01 88:-95W04 89:R86K07Q04T01

90:P95S01R01 91:V88A08 93:M70I 15V13 94:L96I03 95:C88Y09W02 97:T66Y15V05P05A03I03

98:E78D12Q05K03 99:A79T19 100:I81V15M01 101:R85K13 105:V98L01 106:D94G02N01E01

107:Q83H08N05K01 108:A94G03 109:E88D10 110:A83E06S02V02D02T01 112:S97A01 115:G91A05T01 116:T39K36H07P04A02E02M01I01 117:I86V08M02L01 118:A91P04T01 119:V62I21T07S04A01M01 120:V59I14L14T04M03A01F01 121:D42E40Q07K05H02 122:P74A07Q05S05R04L01 123:V46I45T04L01 124:F77V08M03T02I02L01Y01 125:Q83K08R04M02E01 126:G79D12E06 127Ύ86Τ06Ρ01

129:V83L10I03M01 130:V46I39N04A02F01G01 131:F95V01L01 132:A84S13V01 133:N94S03

135:E72D11K09N05 136:R83S09H02C01 138:K96R03 139:A55T18V18Q04I01 142:R97Q02 144:S91T07 145:L91V06Q01 146:A78T13V04L01 148:M88L11 149:R91K08 150:D91N06E01 155:K96R02 156:R93Q05 157:S94T03 158:V79I 16M03 160:E96K01 161:R96Q02 163:Q78K21 167:Q91R07 168:C93Y03F01

169:L94M05 170:V91I04L03 171:E93Q03K01 172:E97A01 173:L90F07M01 174:R78K10Q07S01

175:K87N08E01T01 176:S66T19Y10 177:Q63K30E02R01 179:A79G 10T02D01S01K01V01

180:L53P33Y09F01 181:L58Q16V15F04M02 182:D97N02 183:P97N01 184:T79L07I05K02H02V01 185:F92L04S01 186:L59F32Y04I02 187:F93L05 188:H47Q42S04N03 189:S49C33A12R01

190:I65V15A13M03 191:T88V05M03A01 192:A90S08 194:I90V08 197:S96T01 198:I95T02V01 199:V95I03 202:E61K33Q04 203:R98C01 205:D59S13A10N07G04H04 207:K52Q21R11T07E05S01

209:P49R24Q09H06K05G02T01 210:Q55E28R08K03V01 211:F97L02 213:R73H09K06T03Q03E01N01 214:L91M05I02 215:L98M01 216:D67N19H05E03R01 217:L89M06I02 218:F67I 15L12M04

219:Y66N15F13C02 220:Q66E15K08D03R03 221:S43T40I 12V01 222:F91L02S02Y01

223:S48A26T06I05R03V02D01E01L01N01 224:L85I11F01 225:I60L11M 10V08G03S01T01 226:S96G01 227:S97T01 228:F76L12P04I01V01 229:S74Y12W06F04P01 230:S83G08T05 232:V72L15M 11

233:F91Y05L02 234:E92N03Q02 235:L86I06F02 236:F81Y09L07 237:S76P15H04R02

238:G55S18D14N06R02A01 239:F63I27V07L02 240:L92M07 241:K95D03 242:Y62H34F01 243:F93L06 246:T45A22P16S06I04V02K01 248:R72T08V05H04K04S03 249:Q65E12R11K04H03D01 250:I65V25L09 251:Y61S21F08T02N01 252:K68R15S07N05A01 253:N83K06I05M03 254:L68I10M05F05V04T02

255:Q87E08K01 256:E93K04 257:I73V16L07M02 258:N42L31K14I04E03S01

259:D42A28T13N04V03R02S02E01 260:F67Y31 261:I93V05 262:G64A11T07D04S02E02I02N01R01 263:H37R30E14Q11K03 264:S74N14R04V01I01 265:V90I08 266:E91K04Q02 267:K72R12E06Q03M02T01 269:R81Q14K01 270:E61A21K09Q02R02D01V01 271:T89M06N02S01 274:P95C03 275:S87N09T01 276:A46N31S14G02T02 278:-95A04 279:R82K10Q07 281:F85L10Y03 284:T67S12A08C07V03 285:Y74F25 287:L83I13V02 288:R84H07K06C01 290:E54D45 291:K95Q03E01 292:E85D13 293:K87R06S02

294:S86Q04A03L01 295:N63D33 296:P66Q16H09S03 297:H43N29E10D05S05Q01Y01 298:T63S34 299:E95Q01 301:H86S04N03D03Q01 302:H75Q12Y03E02M02F01 303:K41Q37R12E06 306:I52V29M13L03 307:I44L24M12H08Y03N02F01 308:T63S26N08 309:V53T16S12A12L02 310:L95F02V01

311:S90N04A02T01 313:F98L01 314:F95L02 315:A97G02 319:T95S03 320:T65S33V01 322:T93N02S02 325:R89C05L02H02 326:Y93F02H02 327:G95S03 328:F88L09 329:L98V01 330:L75F12I09V01 331:M59L39 332:L96V01 334Ύ88Ν06Η05 336:H82D08E04G02Q01 337:V66I32 338:A44T38L06Q04R02I01V01 340:K56R43 341:V92I06 342:Q66H24Y07 343:K79E08A07V02 346:D73E25 347:Q77R17E02 349:I97V02 351:S68P20R06A02 352:H84D04N04Q03Y01 353:R94H03C01 354:L40P31Q10A09S04V01 355:P98R01 356:A57T28S08E01N01V01 357:L93M04 358:D63E26N06K01 360:R97Q01 361:A49T34S06V04I02 362:K88N06R02Q01 367:D71E28 370:I97L01 371:H81C12Y03R01 373:I95M03 376:F95L02Y01

377:S44A29G20I01L01 379:L88I09V01 380:I37L31V16A06T04S02 382:I66M14L09V05F01T01 383:G94S05 384:V75L18I03A01 386:H93R05 387:M24K17I12V12R10S07C06T04A03 389:T87I09 390:K85Q06R06 391:D92H04 392:T96I01 393:H47L22S08C03N02Y02M02Q02P01V01 397:Y83F12H02

398:I40L31H09T06V05F04Y02 399150148 402:G43N35D20 403:T97I01 404:E81T12D02N01 405:V92I07 406:Y70F25I01 407:P92L03T01 408:I80L11V05F01 409:L91M07 410:S83T05N05H04 411:S78T20A01 412:A82V16414:H83N11R02 416:P93S03L01 417:H31R29Q21K07C05L01S01 418:Y70H24Q03 419:F98W01 420:E90K05D01G01 421:K64Q25N06T01H01 423:D77E13N04Y01G01 424:T56A24D06S04V04E02I01 426:N83Y10H04D01 428:D68G 17E10N01 429:H96R03 433:A92E04T01D01 434:N66K16E10Q04S01 435:G98E01 436:A75N12S04T02R01 437:L80F16V02 438:K85R14 439:K94T02R02

440:N57S22Q08P02T02I01H01M01 441:E80D16P01 442:A94V02G01T01 444:M57I35L07

448:I44M17L15T14A03V02S01 450:K97R02 452:I82L08V03M02F01 454:L98P01 457:G85S14 458:I80L18 460:R95H01 461:N29T24A21S12M09 465:L97I02 466:F96I02 467:F89L10 469:T91S05A02

470:I82L06M05V05 473:N98K01 475:S83T11N02 476:V48L34I14F01 477:A46S31G10R03T03K02

478:S85T07P02G01 479:P84S07L03N02 480:V67M15K11E01L01 481:A85D07P05 482:P95L02S01 483:E70K27 484:D91E05 487:L84F08I06488:T80S15 490:Q39K32R13M05E02A01I01

491:E80V08N02R02K01I01 492:S56N16C11V08I02F01 494:V40F25L20I11A01 495:G88A04S02T01 496:K67R21N08T02 497:V39L30I23M04P02 498:P98A01 499:P90Q04R03S01

500:T38V22P10E05S04A04I04L03K01N01 501:Y86F13 502:Q84K11E01R01 503:I78L16V04

504:C40R33S15Q03H02G01N01 505:F95L02A01 506:L90V05I01 507:P66A25S07 508:R93H02

(xxv) N159

1:-94M05 2:-96A03 3:-95L04 4:M96-03 5:E84A07-03G01D01 6:L81W09M03F02V01-01 7:G61A15S10V04E02-01R01Q01 8:G80-03W03D02V02Y02P01S01 9:A78V11-03T02S01I01 10:-96L01W01 11:F39V30L09A06I06T05-01 12:T81S12G02-01I01V01 13:I59L31M02P01-01A01F01 14:F66L24I03V02-01 15:L90M07-01 16:A57V22G09E03T03I01-01 17:-98L01 18:L59I26A07V03-02F01 19:C65Y13- 05F05L05A01G01 20:L68V10F06I06-03A03 21:S85L05-03P01F01T01 22:C89F03G02L01 23:-96L03 24:L92H05 25:L66A12I09F05V04 26:I51L36V06F02A01 27:L68I 16V07F03A01 28:I45S33W05L04A03F02T01- 01V01 29:A72L07S07E05F03V02T01 30:W81K12R02Q01S01 31:K65R31T01 32:R54K29Q07W05H01 33:R26I18M 15T14L07Q04V04A02K01 34:-98A01 35:-98K01 36:-96G03 37:-98K01

38:S36N23H 13L06Q06R05K02A01T01 39:K58R16H07Q07P04S02N01T01

40:G50R15K14A05E05Y03P02S01L01 41:-96L03 42:G88K03A02R02S01 43:-96G03 44:K66R24N05M01Q01 45:L92F05 50:T92M03A01L01P01 51:P96A02 52:L59I40 53:P98Q01 54:F62L35V01 55:L73I22F03 57:N98Y01 58:L71F20I02A01M01V01 60:Q97H02 61:V56I22L16M03 62:R46K33S07D04N03G02

63:T49S14I09P07R05A03V02F01 64:D46S18G 12K08T03E03F01L01H01

65:A42E31D05G05K03N03S02Q01R01 66:T72L09I09P04A01M01 67:F56L31Y06P01M01 68:Q54K41T01 69:S96P02 70:F52L46Y01 71:M54L35E05T02 72:K81A12E03R01 73:L93I03M03 74:R57S17Q10K07H05 75:E74K13D07H01Q01 76:K91I02R02Q01T01 79:P83S13T01 81:F97Y02 83:V94L03I01 84:Y89H05W01F01 85:M37L35F25 87:P67S18T08L01N01 88:-94W05 89:R87Q05K05H01 90:P79R16Q03 91:V90I09 92:V88L11 93:V87I09F02 95:C96Y01 96:G98D01 97:H82Y12S01 98:E74D14Q08-01 99:A92T04V02 100:V91L07M01 101:K97R02 102:E98D01 105:V83I 15 106:D95G02N01 107:Q58K18R11H09N01 108:A88G 10 109:E51D46 110:E53D37Q03A01K01N01 112:S92A03C02 113:G98D01 115:G78A11T05K01

116:E64T16Q05A03G02K01V01I01 117:L40M40I05N05K02V02 118:A50P46T02 119:S53T37V05I01L01 120:I40L40V16F01 121:E68D27Q02 122:R79K13Q04S01 123:N60T19I09S03A02L02 124:F91T03V03 125:Q68N10K09H04E03R01 126:G98S01 127:H50Y33F14 129:V83L11I05 130:A61V30G03I02

131:L58F29M07T01V01 132:A76S22 133:N94S03D01 135:E94D05 138:K62R36 139:Q45I42V04K03S01 140:L98M01 142:R92H04Q01 144:S95T03C01 145:L90I03T02V02 146:T81A06S05I02 147:I43V29T22A04 149:R90K07Q01 150:N50D42S03 151:F96L02 153:M98V01 155:K96R03 156:R71K21C03Q01T01

157:S94T03N01 158:I95L02-01 159:E98Q01 160:E96G01Q01 163:Q96A01 166:A96T01 167:Q48G45S04R01 168:Y46F45C05M01 170:L79V14M03I01 171:E90Q05K02 172:E83A07K03S03T01 173:F54L38I06

174:R81H09Q03S02 175:K90E03N03-01 176:T89V06A01M01 177:K82N05Q05R02E01H01 178:G81E14A03 179:A52K21S07L05E04Q04N01T01V01 180:P98Y01 181:I47F44V03L02T01 182:D67E24N05K01 183:P94L03 184:T92I03S02 185:F72Y12L06S02N01 186:F59L15Y15P04I01V01 187:L92I03V02 188:S95G01

189:R79C11H06 190:T59A35S03 191:V93T03 192:S93A02C02 194:V85I 14 196:S56C43 197:S98A01 198:I50V48M01 199:V94A02L01 202:S51N16D11K09E07Q01H01 203:R98C01 205:D94E04 207:E90Q05K02 208:D96N03 209:K81Q10E05P01 210:Q44E23T11K09C04R02D01 212:L76Q22R01

213:S31K25A14N11T07Y02D01E01H01 214:L97M01 215:L68M27V01-01

216:R31Q27K09E09N05D05H03G03-01 217:M64L18I09K02V02-01 218:I73M 18T03V02L01

219:N90H05Q01 220:E74N14K03D03S01Q01 221:S69T10F05L03I03A01M01-01Y01 222:F97L01

223:I42R24V09L06T05W05F01S01 224:E92L04F01 225:M79I 11L06V01 226:S96N02

227:T69S16K05I02M02R01 228:P72A09T05S03G03V01L01 229:W94R02S01 230:A63S22G06T05 231:Q94L02K01 232:L79F14I02V01 234:D83E08N07 235:M87I 10T01V01 236:Y74F22A01

237:S55P16V07A07W07E04 238:G51S22C09R04T03N02D01H01 239:I55V18F13L11 240:M72L25I01 241:Q61K25R07D04 242:Y89H05F03 243:L62F34I01V01 246:R53P36S04G03K01 247:H95Q02

248:N56T15H10K08S03M01R01 249:R61K25H08Y03 250:I65L16V14M01 251:Y85F09P02L01H01 252:Y46N22H09D07K06R02A01Q01 253:L66I 18N05H05F01-01 254:I51L30V08M03Y03F02

255:E87K03S03G02Q01 256:E50D32K08A03V01G01T01 257:L75M20I02A01 258:K69R20H05L02

259:D66V07A06L06E05K03R01 260:F98Y01 261:I88V09 262:A83T04V02E01G01R01M01

263:S42E24K20Q04R03A01D01H01 264:R87K11Q01 265:V88I07A02 266:K84R05Q05E02M01

267:I50K18M09A04Q03R03L02T02V02S01 268:N92H05 269:E49Q42K03A01L01 270:A58E32Q03K01R01 271:S50T48 272:L74F25 274:P88S05H01L01A01 275:N38Q37S14K03E01G01D01H01

276:N58S20F11C05H01 278:-94A05 279:R95Q04 281:F91Y08 284:C88S05A02Y02 286:L98I01 287:I94V01 288:K59Q34E03R03 290:E48H40Y06Q03N01 291:Q55K37E07 292:E57D42 293:K95R01Q01

294:N40D18Q12G 11S10K03E01 295:N87D07K04H01 296:P96A01

297:H32N20S19Q08A04L04D03Y02K01R01 298:T51S47 301:N81H09T05S01

302:L55M13T11I06V04D01F01Y01E01 303:K77R08E07T03Q01 306:V71E22I03 307:L81M07I03E02T02 308:T95S03 309:T85V07I04A02 310:L87F05I03V02 311:N88Q03H02D01G01S01 314:F92T01V01I01L01 315:A92G06 318:E97D01 319:T94S02M01 320:V90T07 321:S97G01 322:S88T06A01F01 325:R92K03H02 326:Y97F01 327:G92A03S01 328:F77L11I07M02 330:L79F14I03V02 331:L90M07I01

332:M81L09V03I01T01Q01 333:K96R03 334:Y66H30F01 336:E88K03D02H02A01 337:V94I03

338:E56Q38G01L01A01 339:A65E29G02V01 340:K97R02 341:V55I38M05 342:H79Y10Q06L01

343:E79Q15K02R01 345:I98V01 346:D60N33E01S01 347:Q50R37H05S02G01K01 349:I94V05

351:P38R25H 12Q09T07S03 352:H51N38D03S03 353:R94H02K01 354:I49V18S12L07T07A01M01 355:P98T01 356:S44A31N 16R03K02G01 357:V50I24M11S06A04T02 358:E50D37N07K03

361:V35S23A10M 10R05G03P03L02I01K01 362:K57Q20R14N03H01S01 365:Y94F05 366:T94M02V02 367:D87N09E01H01 370:I98V01 373:I89V07T03 374:Q98L01 376:L51F22V13C05M03-01I01

377:T53S28I06A03V03L02-01 378:D87N09-01 379:I73L22V01F01 380:V63I23L06A03T01

382:M74L18V05F01 383:G75N09S07D06 384:V83L11I03 385:P87A12 386:H98R01

387:N39T18M10A09R07K05I03V01S01 388:V98L01 389:I56T40V01 390:R84C10E02Q01 392:T98I01 393:H47Q26E22N01 395:R97Q01 397:Y93F06 398:L55F22T14I03M01 399:L71I28 401:K98Q01 402:G94D05 403:T90M09 404:D62E19N11T04 405:V87I 12 406:F55Y35I05L01W01 407:P90A04T02C01

408:L76I09M06V06 409:L85I12-01 410:G70S28T01 411:S79T18M01 412:V87A12 414:K35H31R24Q05 415:D96E03 416:P96S01A01 417:K73T16A03R01S01Q01 418:Y65M 14K06Q05H03S01N01 419:F97W01 420:R47K35S13C01 421:Y42N16S14D11H03R03K01Q01C01T01 423:D50E30N09F03Q01Y01S01

424:A55S11T10V05N04G02I02E01R01D01Q01 426:Y46N39D07H03E01S01 428:Q46E27G23S01

429:H74N25 432:D98E01 433:E94A03D01 434:Q45N37E07K04D01S01T01 436:R72H09C08S04G03 437:F98L01 438:K94R04 439:K96R02 441:D49E48H01 444:V83M09I03L03 445:P87A09V02 447:S96A03 448:S85A09T02 450:K98R01 452:I52V32A03M03L01N01T01 454:L86V11F01 456:E94K03 457:A68S18G 11 458:L53M46 460:R94L03 463:L98I01 465:L95I04 466:Y61F32I03V01 467:F88L10V01 468:T94I01A01S01 469:S47T45F02I01A01 470:I86V07L03M01 471196103 473:N56S22R18K01H01 474:F97L02

475:S62T13Q10R09H01A01 476194F04 477:K42R42Q10H03 478:S61P36A01 479181P10T03S03

480:V81L06I03K03E01G01M01 481:P76D09A08H01S01L01 482:P96L01R01

483:A42E29K09Q09N02S01V01T01 484:D76E18N01Q01 485:I90L05V02 486:D92N03P01

487:I63L16T09V05P02 488:T66S16A08N03K02 489:P90H07-01 490:K52Q21L10R07E04-01A01

491:I40E22V16L07A05M03-01S01 492:S88N05F01-01V01 493:G98-01 494:F94L02-01

495:G61A25L05I01T01W01-01 496:N85T07K02I01S01 497:I86V07L02M02 498:P96S01 499:P91R06 500:T50F21S08P05I03V03E02A01D01L01 501:Y94F02C01 502:E42Q39K10H03R02 503188V04M03I02 504:C80S15R03 505150V15F13A09I06M03-01 506:V54I 18L11M11C01-01 507:P50A46-01 508:R96H01-01 (xxvi) N169

1:-94M05 2:-94A05 3:-94L05 4:M95-02R01W01 5:E61D24A10G01M01V01 6161P25R05F03G02S01 7159W25S08-04K01P01 8:G69E15-05S04A01N01P01V01 9137V24I20-06A06F03 10:-97W02 11:T83P08- 04I01N01S01 12:T86S10W03 13156T22P08F05G03V02A01 14:A40V29-06I06L06F04P02T02 15190F05I03 16:V61L23I06T04M03 17:-96L03 18:I36V26T19L09A06F01 19:C68S11F08L05A03G01Y01 20:V84L09I04F01 21:T32L22S20A11I06V03F01M01 22:C58F31L08-01S01 23:-94L05 24196F03 25:I34L26V26S08-02A01 26:F81L16-02 27187I08F04 28:S44F37L06W06Q03Y01 29:V56L32A09Q01 30:W95I03Q01

31:K31R31N16T12S03W03I01 32:K61Q11H09E05R05N04Y01 33:G38S29R10N04D03K03L03M03-01E01T01 34:-97A01S01 35:-98K01 36:-94G05 37:-96K03 38:H32R18T11G10S09F08Y04C01L01N01Q01

39:K65T12R11G05Y03P01 40:R48G23K13A04W04H01M01Q01T01 41:-75L20A03 42:G77R12-03A03E01V01 43:-89G10 44:R56K34L03N03S01 45196F03 47:P98S01 50:T73I08A06P05V02F01H01M01 52197F01P01 53:P98S01 54:I80F06L06V04H01 55:I73L13F11Y01 56:G98W01 57:N98E01 58145I33M18S01V01 59170M26F01T01 60:Q98A01 61173F10V06I04M03T01 62:N62D32G02E01K01 63167F11T11H03S03P02 64:K89W05-02Q01R01 65:D59N32A04E02G01 66:I38L23M20V10P04F01H01

67:P69A09F06T04L02S02Y02H01V01 68:A53T15K12S08E04M03G01N01 69:S84T11F03 70163F31M02Y02 71:S80M06C03D03H03L01N01 72:K80E06R06Q05 73195M04 74:A84S13Y01 75:K58E39Q02

76:K45E37Q15D01V01 77Ύ97Η02 79:P88S11 80:V76I23 81:Y79F17C03 82:T94S05 83176V20I02

84:Y81H09R06W02 85151F26I12V05M03 87:S45P25T22L03M02A01 88:-94W05

89:Q65W10H05T05R04S04E01K01L01 90:P48R34T06I05L03 91:T43V41l09A03-02 92:V98I01

95:H83C08Y08 97:Y96H02L01 98:E51N18D16K06Q04S01T01 99:A62I20V15M01 100:V88L05M03A01T01 102:E94D05 105:I75L09V08C05T01 106:D76N13G05Q03 107:Q73H13K10-02 108:G91A08 109:D83E10V05 110:E62I23N10A01D01V01 112151M20S15G08A01E01F01Q01 113:G65E19D05Y04N03C01 115:G84A15 116:N29P20H15A09R09I03K03Q03E02D01L01S01 117:I37V19L18F15M09 119:I88V08M03

120:I52F34L05M05V01 121:D52E36S05Q04G01 122:D73N06E05R05K04A02H01

123:T51I15A10V08F05N05S02L01 124:Q39L15I08V08F06T06N05A03H03S01Y01 125:K76R16G03- 01E01Q01 126:G96K01R01V01 127:Y48Q26H12L05D01K01N01R01S01 128:G97R02 129:I54V23L22 130:V44L24I19F08A01S01T01 131:F93V03S02L01 132:S97G01T01 133:N46H33R10S05D01E01Q01 134:G98S01 135:E83D06N05Q02R01 136:R73T13K11S01 138:K94R04E01 139:Q83L05V05H02C01E01 140:M52I23L16H03N03V01 141:R98H01 142:R95Q02C01K01 144:S82T15A02 146:M81T17L01 147:T98I01 149:R97K02 150:N94D04K01 151:F98L01 156:R96K03 157:S87T08G04 158:I66L25V04M03 160:E95D04 161:R98H01 162:V65I34 164:E97K01Q01 167:Q77R19H01W01 168:C53F22Y18H05 170:V96I01L01M01 171:E86Q08K04R01 172:E89A10 173:L88F11 174:R79Q06S05T03K02A01H01 175:K84Q05E03N03H01R01 176:T89S05M03R01 177:K46E43Q05N03A01 178:A51G44S03C01 179:Q95K03G01 180:P96F03

181:F66T11N10L05V05 182:D93N06 184:T82A08V06H01S01 185:F93V04L02 186:I70L11T11V04A01 187:L95F04 188:S52G30A15Q01V01 189:C93L05Y01 191:P76V10S06T05 192:C88S10F01

194:V90I05M02T01 196:C94S04F01 198:I88T05V05 199:L84V13I01 201:N56R20G 10H08S02K01

202:E60D25Q06K03N03 203:R91H08 204:F98L01 205:Q27D18H18N18K13P02

207:N41K18D17E11Q05T02H01R01 208:D86N12S01 209:E58K41 210:K58T27E08Q03D01R01

211:F79L19I01 212:L93H05Q01 213:Y33S22T13H09N09Q04R03F02K01 214:L96M03 215:M70L22I06 216:N39D19S17G08M04K03H02R02E01Y01 217:L89I09V01 218:L94I05 219:N96L01Q01T01

220:E76K19A03 221:N91T03I02Y02 222:F88S05V02A01I01L01 223:R31Q18K17N12S08H06T02I01Y01 224:L40Q26R16I05K04F03E01H01 225:I27L25V22F20M02A01 226:N53S37T08A01 227:S74K19T04E01 228:P70R09V06F05L05I01 229:W96M03 230:I44N18C13G10A06T03S01V01 232:L54M23I22 234:N98S01 235:L60F26I05M03Y02N01 236:W52F22L22Y03 238:A23S22K20T17R04I03Q03W03G01 239:L51F34I 12V01 240:I52M22R20L02F01G01 241:K50V16H13D10R04A02I01T01 242:H50Y41P05L01R01 243:L91F04I02V01 244:P98M01 245:G98S01 246:E46K26P12R05S03N02H01Q01 247:H98Y01 248:K44R33Q09H08I03N01 249:A27K24E13Q10R09S05T03H01I01N01V01 250:F58I25L13V02 251:F44S44A03L03N03P01

252:K84E04A03S03N01Q01R01 253:R48N46I03G01 254:L38V32I 12F06N03T02G01M01S01

255:E34K17Q13N12D05T05Y04L03G01 256:D38E34N11K09G03A01S01 257:V45L34I 12C03M02T01 258:K76R11H05I02M01N01Q01 259:N39D20Y15C09R03S03E02H02K02Q01 260:F98I01 261:I93V05F01 262:L87A04M04R03 263:E93D04K02 264:K51R39Q04E03N01 265:V95I03A01 266:K90A05E02R01 267:E76K06M05Q05R03A01 268:H98Y01 270:E60K31G02A01D01Q01R01T01 271:S48T36I 10V04 272:L94P04V01 273:D84N09K05 274:P66H19Q06L05R01 275:N79A11E04D02S01V01 276:N81S11Q05H01 277:P96L02A01 278:-94A05 279:R68Q30K01 280:D96N03 281:Y88F10L01 282:I91T05V02 284:C98G01 285:F76Y23 286:L97F01I01 287:S72I 16D03H03N02E01T01 288:K87R12 289:M90I09 290:E69Q26H03 291:Q82E17 292:E96-02D01 293:K96Q03 294:H34Q27D16N13K03L03 295:N97D01K01 296:P91L06S01 297:Q29E25K12D06N06M05Y05A04G01H01 298:S98T01 299:E88A03Q03V03D01 301:D46H26N23E02K01 302:L68M10V10Y06S03 303:E93Q03K02R01 304:N96E03 306:A45V30I 11T04K03L03M01

307:M30T29V16A11I09N03 308:C44T40V05S04I02A01N01 309:G79A06T06V05S01

310:S53V13L12A08F06I01M01R01T01 311:N67D31S01 312:L98F01 313:F98L01

314:S43T18A16F09V09G02D01 317:T93V04I02 318:E95G02T01V01 319:T98I01 320:T93V05L01

321:S82T13N02H01 322:S52T26A05I05L04N03R01 324:L95I02M01V01 325:R84S12A01W01

326:Y70F22L05W01 327:G87A08S04 328:L89F09I01 329:L98F01 330:L82I 11V03F01T01 331:L73I26 332:M51L45Q02V01 334:H66Y32R01 336:E90H04K03A01 337:V84I 15 338:Q65E33K01 339:A74E12S04- 02D02N02G01 340:K94R03-02 341:V66l31-02 342:H90Q05-02Y01 343:E93-02K02Q02 344:E97-02 345:l90L06-02 346:D83N 10G03-02 347:R83S06Q03-02H02K01 348:V96-02M01 349:I89V06L03

351:R62H23C05S03-02P02 352:N65H12D09S06T05 353:R56Q43 354:S38I22V10P08R08K04L03M03A01 355:P98S01 356:S53C41A04 357:M67I26L05 358:K77E08Q06A02S02M01N01 360:K50R50

361:M39Q20L11A10S06I05V03T01 362:K58D22Q12E04L01R01 363:M59L40 366:T74M22V03

367:D59E39N01 369:V98M01 370:L50V38I11 371:H94N05 373:I73V26 374:Q98L01 376:Y58F40C01 377:I91L03V02A01T01 378:T43D37N11A03H03S01 379:L91I08 380:L47V33I12F03A02 381:P97G01S01 382:S58L30M05F03C01I01 383:N72S19G05D01I01 384:L86M06V05I01 385:P98A01 386:H90R09

387:A74T11E04L03M03S01V01 388:V91A03T03L01 389:T50V24N13A05I04S01 390:R46Q41K08H03 391:D98E01 392:T77I20V01 393:K56Q23H16E03 394:F87L12 395:R73Q25K01

396:Q74G08D05E03K03H02N01T01 397:Y91F06H01 398:V43F20T18I10L02S02D01Y01 399:I88L11 403:T94A05 404:T81N10K02S02A01M01V01 405:V72I26F01 406:F46L46I04Y02 407:P98F01

408:L91M03F02I01T01 410:S90Y04T03F01 411:S76P23 412:V81I17L01 413:L93M05Y01

414:Y37H17F15L15C05R04M03W01 415:D98N01 416:C34S34P09Q06K03R03H02A01D01G01N01 417:K95Q03I01 418:E86Q08A04G01 419:F96W03 420:P72S10K08A04T04 421:N95K03S01 422:P95A03S01 423:E66D19Q05Y04K02G01 424:K56Q23R06T06E04A01 426:D89N10 428:G62Q20E06N05D01K01R01 429:H96N03 432:D95N03H01 433:K76E22Q01 434:N88D08S03 436:S65C13K10N06R02T01

437:F88L05V03I02 438:K50R44Q04M01 439:K98N01 440:T47S40N11 441:D80E13K05

442:Y70C09A08F05H05 444:V52M36I09L02 445:P94A05 448:I37L36A23M03 451:R98W01

452:A69S12I06M04L03V02 454:V46L43A09M01 455:G98R01 457:G67S32 460:R86K06Q04H01I01 461:M88V11 462:E98Q01 463:L87V08I04 465:L98I01 466:F97L02 467:L55F39I04 468:T96A02V01 469:T95S04 470:I87L08T04 471:L98M01 473:N84K11H03 475:T51S30V17C01 476:L94F04I01

477:K95R03Q01 478:P74S18T03A02L01 479:L55V37M03A01I01P01 480:V52G36I04E03K03 481:E53D46 482:P86T06Q04E01S01 483:K56N22R11E08Q01 484:E66D32N01 485:I59L40

486:D39E25S13N09R04V03I01P01T01 487:I44T38V09L04M02A01 488:K75T17D05N01

489:P82N10T04L01S01 490:I44N20L09E08M06V04A03G01K01 491:V41H16T12S10Y04A03F03R03C02E01 492:T47V24S13N12I01 493:G97R02 494:F47L41I09G01 495:I33T17L15G12V10F05S03N01

496:N88S08K01R01T01 497:I45V30L12M09A01C01 498:P93R04I01T01 499:P75Q10R10S03

500:P51S17Y10H09I03K03A01F01R01V01 501:Y74F24S01 502:K62Q36E01 503:L98M01 504:C89R06S03 505:F48L45A04C01 506:I44L43V10F01H01 508:R87H11Q01

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1:-96M03 2:-96A03 3:-96L03 4:M98-01 5:A70S13E05G04T03-01D01 6:A64V20L07P02F01-01I01

7:L92S03I01F01 8:G96S01 9:-94A03V02 10:-98W01 11:I73V15T07A03 12:T86S07V04 13:V58I25L13A01M01 14:A88I03T02F01V01L01 16192V07 17:-98L01 18:V86G05L03F01A01 19:W92C04L02

20:V48M30A07L05F03I02T01 21:A68V20S07T03 22:T64F09V08I07A04C03L01 23:-96L03 25:L86M11 26:L77F11I03V03C03 27:I66V20L07A05 28:S93F03L02 29:I70V15L05M04A03 31:K79R19

32:Q72H18K07R01 33:I70V16R05M03L01G01 36:-96G03 37Ύ65Η26-05Κ01 38:S95R03 39:S89R05G02N01 40:W88R11 41:-92L07 42:-94G05 43:-94G05 44:K45N45Q05R04 50:F92T05A01 54:I91F04L03

55:I71V13L11F03 58:L66I 19V14 59:F51L46Y01 60:Q95N03 61:L92V05I01 62:D69E26N03

63:L55I23F09T06W02V01 64:K94N02S01R01 65:N66D29A02E01 66:I79V12L03F02P02 67:P96F01Y01 68:K97Q01 70:F83L15Y01 71:T80A04S04G03M03H01 72:R62K35 74:A94S05 75:E66K20Q12 76:R86K07E03Q02 77:Y50F49 83:L84V13I02 84:Y84H13W01 85:L86V11I02 86:G98A01 87:S92P01T01W01 88:-96W03 89:R70Q25N03 90:R94P03 91:V49I20T19F05M03 93:V98I01 94:L72V15M10 95:H94C03Y01 98:K87E09Q03 99:A90P05V03 101:K78R21 102:E98D01 103:V68A28M01-01 104:L98-01 105:L91V04I02-01 106:D61N22Q05T05-01E01 107:H52Y39L03R02-01 108:K84G07R06-01 109:N80D13E04S01 110:E88D10 111:F90L09 112:S96A03 115:G94A05 116:E62D30N03A02K01 117:I72N09L06V03M03T01Y01

118:P79F09A03H03Y03 119:A62V26G05I03 120:F88I03L03Y03 121:Q56H17R11E07D04

122:A35E28V16L05R03K02M02F01 123:H64Y24I06F03 124:K67R10Q09N04T04E02 125:-93K06

126:D62N22G07E02Q01S01H01 127:K46R29N06S05Q04Y03L02 129:I90V06E01L01 130:I74T15V07S01 131:F96N01V01 132:N90S09 133:N96Q01 134:G94S02A01 135:P85E09R01L01S01 136:T77G08R07S04W01 137:W98S01 138:K75R18Q06 139:D86Q07E03T01 140:T53V22I15L05M01 141:R98M01 142:R98G01 143:F78L16S03A01 144:S93A03T01 145:L98R01 146:T69S23M03R01A01 147:T54I30V08A03M01

149:R98A01 150:D78N19T01 151:Y64F20L10W03 153:M98T01 154:G98D01 155:K97N02

156:Q63R18E07K04L02H01 157:G76S16A03R03 158:N92I07 159:E98S01 160:E39A21Q19S11D03I01 162:I98M01 163:Q98R01 164:R81K08E07G01 165:E98I01 166:A73I11V07S05T01 167:H50Q22P19G04R01 168:F84Y06L05-01C01 169:L98-01 170:L68V24M02I01-01 171:E77D07Q06G05-01A01 172:A54E37V05-01 173:L90F07-01 174:R82K12S02-01 175:K82G09N04E02-01 176:T98C01 177:Q63K13N08H05R05E01 178:G96S03 179:Q93R03K02 182:D97N01 185:F96L01Y01 186:L62V33I03 187:I60L30V08 188:G94S05 189:C55F24G12Y04A01S01 190:A87G09T02 191:P94V05 192:C60Y16F13S05L03 196:A62S26C07F02 197:D90S07K01 199:L93V05 200:F98L01 201:H49R33N09G05C01 202:K64R18E05D02H02Q02S02 203:R58H41 204:F88L03V03A02S01 205:D93N02P01 207:N43K16E11T09D07S07M01

209:K66E21Q05R05D01 210:T60K31Q05M02 211:C39G23F20A11I02S02 212:L88Q06R02V01

213:R91T05H01 214:L79I 11M08 215:M68L15Q15 216:S41R15Y15H12N07K03T03 217:L90M04I02A01 218:F88L04I03Y03 220:E97A01 221:N88D07T01I01Y01 222:F96L03 223:Y71H13R07Q05S01 224:L98F01 225:L94I01V01M01 226:S97N02 227:T90S09 228:P86G07S03N01 230:L64I30G05 231:Q97L01

232:L84V06A03F03I02 233:Y95H03F01 235:N70I15S05Y04F01L01 236:F94V01Y01I01 237:S50P37A07G03 238:S49D24G09N08R01H01Q01T01 239:Y68F12L11C05I01 240:L81M09I07V01

241:R38H31Q13D05Y03N03C01K01 242:Y93H04C01 243:L89M10 246:S87P05N03T01 248:R88H04W04Q01 249:K98R01 250:V54L25I 16F01M01 251:M47I22L20F09 252:K90R05A03 254:V82A06F03I03L01T01 255:S74A13E05Y03Q01 256:E94K04 257:I75L11V09A03 258:K98R01 259:D35E28Q14A11S05V02K01 260:Y90F08 261:A44T30V16I07 262:L60S26A06F03R01 263:E82A16 264:R76K09G05Q04M01

265:V70A22T03I01L01 266:K98E01 267:E80D13M03R01 268:H96N02 269:Q47L27H18E03R01Y01 270:Q50E22K18R03T01 271:S88T07L02V01 273:D83E14A01 274:P79S08A05L04I01 275:N62S30G02K01 276:C89S05N03 277:P95L01S01 278:-96A03 279:R90Q07 280:D93G05 281:F60V18L17Y02 282:T79I13L06 284:C74T13S09V01 285:L79M13F07 287:I32M20V20L14A05T03R01 288:E88K07Q03 289:M90L09 290:E80Q09A05R03-01 291:K91Q05-01E01 292:E90D06G01 293:K81R15N01 294:H64Y16Q12K03 295:S76N11K03T03G02R01 296:A39G10K10P10T10S08Q05E01V01 297:E68D13K11N03Q01

298:P73S15R06I01L01 299:M23L22G19V13W12E07 300:Y77F18H02 301:T83N09H03D01S01

302:L56M35F03Y01S01 303:D50E49 304:N75G16S05D02 305:I84L07V07 306:A55S18T18V07 307:V85A06M05I01 309:V66L22T05I03 310:A92L04F01S01 311:D96N03 312:L94M03 313:F79L20 314:F98S01 318:E96V03 321:S98N01 322:T96A03 325:R96K03 327:G96A01S01 328:L98F01 330:I90V07L01 332:M83L15Q01 334Ύ83Η16 336:E96H02 337:I62V37 338:E95Q04 341:L92V07 342:H98Q01

343:E92K05Q01 347:R98K01 351:P92R07 352:S75N09T08D01E01H01 354:I73V11S07L03M02

356:A83S13C02 357:I58V26M 10F02 358:K88R05E04A01 360:R93K06 361:L75Q11V04S03A02I01M01 362:E66D18Q07K03N03 366:M74L17T07 370:V92I07 374:Q98L01 377:I96L01T01 378:D45N42T11 379:L94I05 380:V66L19I 14 382:S93M03L02 383:N93G03S03 385:P79L09F03S03N02

387:E83A06K02V02I01M01 388:A88V07M03 389:T83N11I03 390:R58Q40 392:T93I03V01

393:V33M32I 13H07T05E01K01A01Q01 394:F95L03 395:R88Q11 396:G96Q02 398:V64L17I 11T05 404:V77T10I06L05 405:V67I26L04 406:I77V14F05Y03 408:T92L07 410:D88S09T01 412:L57V39I02 413:L96M03 414:Y72F17H06L03 416:N35S28K16D08P04R04E01 417:Q88K08E01H01 418:E95Q04 419:F98W01 420:P92K04A01 421:D70E18N10 423:E93D04G01 424:K73Q15T06E03 426:K84N08D04M01 428:E90G09 432:N81D18 433:E97G01 434:N76S11E03H03K03 436:K92S07 439Ύ92Κ07 440:S95N04 442Ύ76Η18Α04 444:K92M07 445:A54P43V01 448:A89T10 452:V92I03M02 454:V84A11L04 463:L97V01 465:L98P01 466:F58L41 467:L90F08 468:S50T24A18C04I01 469:A81T09S05I03 470:I92V05L02

473:H90N07K01 475:N91T07 476:L97F02 477:K97R02 478:S70P29 479:L95P03 480:V93I03E01

481:D86E09S03 482:P98R01 483:K85E09M03 484:D92E06 487:L86I 10F01 488:S67K11T11N05R03 489:P96N02 490:I63V15A05E04S03G01L01T01 491:T47A29V10N06H04I01 492:I71V15S05N04T01 495:G70A27N01 496:K30S29C17N10R10T01 497:I84V12M02 499:P92R07

500:H49R24E07P05S03D03I03Q01Y01 501:Y90F09 502:K90Q05R03 503:L96F03 504:C98R01

505:V75L17F03A02 506:I84L09V03T02 508:R97C01

(xxviii) N196

1:-85M 14 2:-91A08 3:-90L09 4:M92-04A01Q01 5:E92-04S01T01 6:A77L12-04G01S01T01V01 7:A62S10T10- 07V04P02G01L01 8:G72S12-09C02A01P01 9:T78-09A04V03S02P01 10:W81-14G02C01P01 11:A76T15- 04L02P01 12:-85T08S04L01 13192-07 14:L87-07I04V01 15:L90-09 16:V42-30A17L08M01 17:-96L03 18:L81V08-04I03A01F01 19:L80C08A05-02V02F01 20:L95-02A01M01 21:L78S10-04V04A01 22:L78C05- 04V04A03F01I01 23:-94L05 24:L77V14-04A02H01 25:L88V07-02A01S01 26:T42A27L12S09P03-02I01V01 27:L97-02 28:A64V09L08S08T04-02G01H01 29:L85A08-02R02N01 30:P69S10W10-02L02R02F01Q01 31:R45G23-14A14E02 32:T60K15-11S08I02A01R01 33:R75P14W07S02-01 34:A49T31- 09G02S02D01M01R01V01 35:R68-10P08G04Q03K02H01S01 36:-92G07 37:-96K03 38:-88R08K03 39:- 88R11 40:-88Rll 41:-94L05 42:G92S02-01D01I01L01 43:-94G05 44:H76R17Y02C01P01Q01 45:L97A01R01 50:A55T41P02M01 51:P90V05Q02A01 52:L98D01 54:L98S01 55:L98R01 56:G98I01 57:N97A01G01 58:L97A01V01 59:L97G01V01 60:Q96P01R01T01 61:L95I02P01R01 62:R85D08K03G01W01

63:P83T07R05L03 64:G85K09S04 65:A85E09K01L01P01R01 66:L94P05 67:Y83L08F05Q01T01

68:S57L15K12P03A02C01N01Q01R01T01V01W01 69:G84S12E01P01 70:L85F07S02Y02E01P01

71:L77M18C01T01V01 72:R74K15Q09G01 74:S98G01 75:K81E10Q04R02A01 76:K96R02Q01 80:V98M01 83:V92I07 84:Y57H40W02 87:P85S14 88:W94R04-01 89:R91Q08 90:R77P21H01 95:V85C12S01

97:H75Y15Q05R03 98:E67K15D12Q03R01 99:A98T01 100:V98I01 101:Q50R34K15 102:E97D02 105:G83V14E01R01 106:G65D29E02N02 107:Q92H07 108:A92G05P01 109:E98N01 110:E94A03D02 112:S91N04G02A01 115:G96A03 116:T45M32E08A07I01K01R01S01V01 117:L64V20I09M05 118:A89P10 119:T83V09M05G01 121:D87E08Q04 122:R37G36K14Q10P01 123:T85I 14 124:F92T07

125:D72K09N08Q04G02E01H01 126:G89S07C01D01E01 127:H85Y12L01 129:V91I04L03 130:F84V12L02 131:F95V03L01 132:S74A25 133:N97S02 135:E96Q01T01V01 136:R98Q01 138:R70K28Q01 139:Q98S01 141:R98K01 142:K71R27G01 143:F90C04L03V01 144:T90S09 145:M41L29T25A01I01V01 146:L85T12Q01 147:A78T16S02V02 150:D85N10E02A01 151:L84F11M01R01V01 153:M98I01 156:R90P05Q02K01 157:E87S11R01 158:G87I 11V01 159:E97G01Q01 160:E92K02V02D01Q01 161:L83R12H01I01V01 162:I98V01 163:Q96R03 164:A81E15L01S01V01 166:A68V25T04I01 167:Q76R21G01K01

168:C65H09N09R05Y05S03 170:V96L03 171:E92Q03K02D01 172:A85E10S01T01V01 173:F84L14I01 174:Q72R21S04W01 175:G49E23K18R03S02A01D01 176:T95M04 177:E56K31Q05A03G01V01

179:R54Q21H09A07K03C02S01W01 180:P95A04 181:F96L03 182:D89N10 184:S87T12 185:L76F11M10V01 186:L97F02 188:A83S15V01 189:Q89C05R04 190:A98T01 191:T88V11 192:S92C05A01 194:I55V42M02 195:V50I44T02A01M01 197:S91L08 198:L88I 11 199:V31T27I22L17N01 200:F96L02V01 201:G89D09R01 202:L64I09E08R05Q04V02A01C01F01K01 204:F80L18M01 205:P70S15D14 207:E76D16T05K01

208:D91N05S02 209:E54K45 210:E82K08Q05D02S01 211:F98S01 212:Q83L12K01M01R01

213:A83T11E02G01S01 214:V74L18M05A01 215:V70I16L12 216:R61Q28N09L01 217:A87I04L04M03 218:A85I 11T02 219:G62S18N14A02K01R01 220:G84E12S01W01 221:T74I 17Y03V02A01M01

222:L62V17F11A05P01T01 223:L68V14R08T03M02S02A01 224:G81L09E03F03A02

225:I51V36M08L01Q01T01 226:S98C01 227:S98A01 228:P95R02Q01T01 229:W92G05Y01 230:G98A01 232:T62A16L12S04C01I01V01 233:Y95C01H01L01Q01 234:E90N09 235:M90I09 237:S87P11F01

238:W50R35S07Q04D01H01 239:L60F28I 11 240:L89M 10 241:Q63K12R11D08H01P01W01

242:P54H27R07Y04L02A01C01F01Q01 244:P98S01 245:G96S02A01 246:P92S04A01L01

247:H92Q03N01S01Y01 248:T68H10K10A03R03G02M01 249:Q81K11R04D01E01 250:L84I 12F02 251:L70F15Q12T01 252:G37R23H21K08S04A03C01 253:H82N12Y02Q01R01 254:L65V29F04

255:G61S15E12D08C01N01 256:T75K09I05E03V03A02 257:L91V08 258:A85K11G01V01

259:A71T14D11G01L01 260:F98P01 261:A49T29I 12V07S01 262:V56A20I09T07R03S02Q01

263:Q67E17R11D01S01W01 264:Q88R10H01 265:V96I03 266:Q80K08E04G03R03 267:R54Q32M07K04E01 268:H98C01 269:Q64R22K07E05 270:G67E27A02D01Q01R01 271:S47N31T15R03D02

272:L85F05V04P01S01T01 273:D78Q08G05H04E02 274:T58A20P18S02 275:S84N10A03E01

276:G78S16A02R01V01 278:A92P05V01 279:R83C10L02H01S01V01 281:V60L22F09Y04I03 282:V85I 14 283:D97E02 284:A81C12-02D01S01T01 285:F97-02 287:L87I 10Q01R01 288:K97G01R01 289:M95I03F01 290:A80E14K01R01S01T01V01 291:Q67K29E03 292:E97K01Q01 293:E50K47G01Q01

294:Q87K04E03H02G01R01 295:D68N28A01E01G01 296:P90L03S03Q01T01

297:N64G15S10D05E01H01Q01 298:T83S11V02M01R01 299:E98G01 300:F87L09I01P01W01

301:T85H10N02D01 302:E41D35M07A05H03N03Y03 303:K87E11T01 304:N96D03 305:L88M09F02 306:L87V12 307:M98L01 308:T98N01 309:V88T10A01 310:I43T36L11V05F02 311Ύ83Ν16 313:L87F12 315:A97S01T01 318:V45M41E11A01 319:T98S01 320:V74I 14T11 321:S77G22 322:A52T45N01 324:V51I29L15T03 325:R83G07C04S02H01Q01 326:Y97F02 327:T48A36G10S03V01 328:L87F12

330:L90I05V03 332:L83M 12Q02V01 333:K91R08 334:Y96H02S01 336:Q58E22H12R04D01

337:V90I07A01F01 338:Q97H01Y01 339:E60K29Q08D01R01 340:R74K12Q08C02L01W01 341:V97I01M01 342:R49H25Q24 343:E91K03A02Q02 345:L87I12 346:T54D12I12M10N04A02R01S01 347:R84Q15 348:E87V12 349:L87I12 350:G90P05Q02E01 351:A61P15R14E04D02T02 352:G83N08D03S03E01 353:R65Q31H01W01 354:A69V11S10G03E01L01R01T01 356:S51G41A04C02 357:L87M12

358:G64E14S12Q04R02A01 361:A75T08S05V05G02P02 362:R90K05H03 363:L87M12 365:Y94F05 366:T98A01 367:D98N01 369:V98F01 370:L88I11 371:H98N01 373:A82I12V03T01 376:L85F14

377:L90S05I03 378:A87D12 379:L91I08 380:V88I10L01 382:M98L01 383:G94S05 384:V32I29M28L09 386:R63H36 387:A61T27V07M03I01 388:L71V20I07T01 389:T91M05A01V01 390:R67K27Q05

391:T85D12P01 393:C56R22H10S04E02Q02I01 395:R98Q01 398:T96E01I01M01 399:L89I10

401:Q76K22E01 403:T98I01 404:E87T05D03N03 405:V97I02 406:F94I03L01Y01 409:L88I11 410:G87S12 412:V80I20 414:H97R02 417:E56K18A12N05T04S01 418:V69I11Q09F03Y03A02 419:F96W03

420:E62K20Q12D01P01R01T01 421:Q56N21E07K05H04R04423:E94A01D01G01K01Q01

424:E84A08T04K02 426:N87H10Q01Y01 428:G69D24E03R01S01 429:R84H15 430:F98M01

432:D97G01N01 433:A69E17T08V02D01R01 434:D72N14E09Q02H01 436:R68K17S08H03Q02

437:F85L11I01V01 438:K64R21Q11I01T01 440:H41Q32N14P09G01L01 441:E81D11K05A01 442:A98S01 444:L88M11 446:F84Y15 448:L85A09S04 452:V76I17M04T01 454:L97P02 457:G98A01 459:A95V04 460:R85K05Q05H01N01 461:A74T11M10S02P01 462:E98Q01 463:L94I05 464:F89W10 465:L98V01 466:L55F44 467:F84V09L04A01 468:T94A05 469:A67T28S04 470:I91L05V02 472:Q97H01K01

473:A77N10T05K03G02 474:F98C01 475:S87T10H01Y01 476:L95F04 477:E67D18K07R03S02G01 478:S71T12G07P07N01 479:P89L07A01Q01S01 480:C76S09V09E03R01 481:P87D09L02S01

482:P90L05R02V01 483:G65D14E12S03A01C01Q01 484:A57T17D15E08S01 485:L87I12

486:S83D12N02H01 487:L92I05V01 488:Q76T11K09H01R01 490:A81E07T07Q02K01S01 491:V85I14 492:S97C01R01 494:L81F17V01 495:F80A10G09 497:I91M04V03 499:P74Q14R10S01

500:A71D10P07T05S04 501:F88Y11 502:Q97H01L01 503:L98M01 504:Q76C12R08L02

505:V65F20L07A05I01 506:R64W10V08Q07I04H03L01 507:P94S03H01T01 508:R52T18A10H08- 02C01E01I01M01S01Y01

(xxix) N200

1:-95M04 2:-96A03 3:-95L03 4:M98-01 5:L86E06D03-01P01V01 6:A75L08D06G04V01-01P01T01 7:S91L03- 01T01 8:G93-02E01S01 9:L77M08A06-03V02I01 10:-98W01 11:L85T04I03-02A01 12:L86T06-02S02A01V01 13:V81L10G03-02A01 14:A73T10F03L03V02-02I02S01 15:L75V10I08-02A01F01 16:L80V09A03F03-02 17:- 98L01 18:A70T09I05L04F03-02S02V01 19:C75F14Y02-02L02S02 20197-02 21:S47T42I02V02-02G01M01 22:V63I15C07L04T03-02A01M01 23:-97L02 24:M73L19F01I01V01-01 25:V73L09I07A06M02-01

26190F03V03I02-01 27:M74L13V07-01T01 28:S95L02-01 29:V81T05A04L03I02-01 30:W97-02

31:R57K21Q15W02-01 32:Q91K06-01 33:R82-10M02K02L01 34:-98A01 35:-98K01 36:-96G03 37:-98K01 38:K83R07Q04N02-01 39157S10F07I06R06V06G03-01 40:R38W33S08L06K04Q03-01A01G01 41:-97L02 42:G90E04S02R01 43:-97G02 44:K86R08S03N01 45188M10 50:T91I03M02R01A01 51:P97A02 54:F84L10Y03 55:I92L06V01 58:Y86L10F02 59:L97F02 60:Q96E02H01 61:L95V03I01 62:N77D19K02 63:T90R04P02I01M01 64:E67K18Q07S02R02 65:Q66D10K08E04N04A02H02 66:M79V06L05I04P02F01 67:Y83L06S03C02F01R01 68:N61D13S12K09T01 69:S93C04 70:L77I 14F07Y01 71:M85T08L03S01 72:K90Q06E03 73:I67L26M05 74:S78R13G06Q01K01 75:E82K12Q04 76:R74K13H06C02L01Q01 77:Y98F01 79:P93S04L01 81:F96Y03 83:I65V33 84:H85Y12W01 85:L95M03 87:P73S09T07L07H01 88:-95W04 89:R95Q04 90:R81P14Q02T01 91:V54I44 93:V97M02 95:C81Y09W03S02T01 97:Y68H19Q12

98:D60E33Q03N01 99:A95V03I01 100:V95I04 101:K97R02 102:E98D01 105:V86L08I04 106:D98N01 107:Q94H04 108:A93G04 109:E98D01 110:E95D04 112:S93G04N01 113:G98D01 114:R98-01 115:G98A01 116:E87A05K04G01Q01 117:Q90M03I02L01N01 118:A88P06V02S01 119:T91V04F01I01 120:F84Y07L07 121:D75N18Q02G01S01 122:W75R10T10S01 123:L82I 10V03F02 124:F95T03 125:K87Q08E02

126:G96N01E01 127:Y93F03H02 129:V93I02L02 130:A66V18T13 131:F95V01C01L01 132:S95T01G01R01 133:N80S14T02 134:G90W08 135:E98D01 137:A85S06W06T01 138:K90R09 139:Q91P03H03R01 140:L96M01-01 141:R97-01 142:R97-01 143:F98-01 144:S92A02T02-01 145:I92L06-01

146:T54A34S07M01-01 147:T98-01 149:R98K01 150:D88N09 153:V78M 15F03L02 156:R96K01-01 157:G87S09-01 158:I88V09-01 159:E96-02 160:E97-01K01 161:R96-02C01 162:I97-01T01

163:Q86L06K03I01-01 164:E96D02-01 165:E97-01K01 166:A95T02I01 167:G80Q09A03S02D01V01 168:F75Y14C09 169:L97I01F01 170:I69V16L13 171:E71K11Q10D03G02 172:A71M09S06T05E04V02 173:L48F46I04 174:R76Q17S02G01H01 175:G55K13D11S07E06A03N01T01 176:T98R01

177:R45K14N10H09C07G05Q05 178:G98D01 179:A82T05L03K02N02S01Q01

180:F52P22N08L05S03A01I01T01V01C01 181:I87F09M01 183:P97L01 185:F81Y10I03V02

186:F56Y36L03I02 187:L95M03 189:R77K12Q06C03 190:T79A15S04 191:V97I01 192:S98A01 194:V96I03 195:I95M04 196:S82N09C07 198:I95V04 202:D90E04N03Q01 205:D90E06N02 206Ύ98-01 207:E97D01 208:D96N03 209:K95E01Q01T01 210:E89Q05K04-01 211:F98L01 212:L98H01 213:S90T04A01E01K01 216:R69Q10N04G03H03Y02S02K01 217:M93I02L02-01 218:M86I08T02V01-01

219:L69T09G08N06M03D01 220:G72E13Q07R03V01 221:S73I09M06T04V02Y01 222:F81N12K03L02 223:Q74R15K08S01 224:F95L04 225:T77A12M04V02I02 226:A87S12 227:T75S24 228:S73P20A03Y01 229:T67M14W09L03V01I01S01 230:G98-01 232:L98I01 233:Y89F05C04 234:E79D15N04 235:M90I08F01 237:Y45S28H 12P09F01T01 238:S85G06P03R01A01 239:V90I06L02 241:K91D03N02R02 242:H72Y26 247:Q93H06 248:Q89H09 249:Q83K10E03R01 250:A80I 16V01 251:F84I08Y03L02 252:K96A01Q01 253:E67D11N10L06V01G01 254:L75M 10T06V02F02S01 255:Q69K13E07A03R03H01 256:G80K10E05R01 258:E90K08R01 259:D86N08K03 260:F93Y06 261:I84M14V01 262:A56T16I 12V08E03R01

263:K79E11R06Q02 264:K93R04Q01 266:E77K15R05 267:Q66H17M04R03E03A02V01 268:N92H06 269:Q91E03H02R02 270:R68S13E09A03C02H01 274:P95L03 275:N96S03 276:S92A04H01 278:-95A04 280:D78N20 281:F97Y02 284:S89C09 288:R74K13H09Q01 289:M95I03 290:Q81E05R04H03K02L01 291:E79Q12K05-01 292:E98-01 293:K55Q25Ell-05 294:K67N13Q09-05H01E01S01T01

295:N93D02H01S01Y01 296:P91S03V02-01 297:N86S04D02H01K01-01 298:T75S22-01 299:E95Q01-01V01 300:F98-01 301:Y55H24F06N05S02I02C01 302:M73L16I03Y01R01W01 303:K86R07E04Q01 305:L95I03 306:V91L03T03 307:L49M48 308:T97S01 309:T81S10A04V02I01 310:L95V02F01I01 311:N87S10G01 312:L95V04 313:F98L01 314:F93I05 315:A96G02 317:T90S09 320:V92I03T03 322:T83S15 324:L89M08 326:Y95F04 327:G93S04 328:F95L04 330:L92I05V01 331:L97F02 332:M87L10Q01 333:K98R01

334:H84Y13N02 336:D66E27H04 337:V89I 10 338:E84Q10A03 339:A89E09 340:K98R01 341:V74I 19L03M02 342:H91Q04R02 343:E94K01Q01-01 345:I96V02L01 346:D96E01N01 347:R87Q12 351:K53R45 352:N97D01 353:R96Q02 354:Q80S13H03A01 355:P98A01 356:K69Q15S07M04A02R01 357:F74Y14M07I03

360:R80H11K07 361:A58M19L07S07V03T02 362:K89R09 366:T90M08V01 367:E81D14Q03 371:H91N07 373:I95C02F01 376:F96Y01C01 377:G64A17S07C03I02L02V02 378:D80N18 379:M49I 15V14F11L09 380:I71A14L08V04 382:M80L18 383:G89S09 384:L68V15I 15 385:A66P27S05 386:R84H15

387:R84A04K04S03M01 388:V81T09I08 389:T79I 10N06K02 390:K89R08T01 391:D89N07Q01 392:T97I02 393:K71T13H04Q04E01R01S01 394:F98L01 395:R97Q01 396:D57G27E09N04S01 397:F84Y14

398:L55F29T10I03 399:L66I33 401:K96Q03 402:G92D06 404:E88D06T02N01 405:V98-01 406:F92Y04I01-01 407:P96A02 408:M68I 12L10V07 410:G92S06 412:V89L09 413:L94M05 414:R54K19T15H07N01

415:D98E01 416:P84T04R03Y02S01A01C01 417:K79R05N04S03E02T01Q01 418:F88Q04H03Y01

419:F97W01 420:S78P07K06A04E02 421:N71S11K06C03R03H02 423:Q39E19K15R11G06N03D01H01L01 424:D82A08E03T02 426:N83H09D04Y01 428:Q76G07K06E03N02R01 429:H93N04 433:E64D31G01R01 434:K78N16R03 436:Q91S04R02H01 437:F88L10 438:K98R01 440:S60N35I02 441:D84A06E04N02P01 442:A95G04 444:V77M 13L04I03 448:I77L08V06A04S01T01 449:G98R01 450:K98R01

452:Y65N14F11I04M02 454:F79L20 456:E90D08 457:G90M03N02S02 459:A97T01 460:R90K08

462:E98Q01 465:L95I02V01 466:F95L03Y01 467:L73F24V02 469:T74N11S07I05A01 470:I95L02V02 471:L56M42I01 473:N94H02K01 475:R66H12C12T06S02 476:F89L10 477:K80R10Q04E03 478:S86F08P03 479:P85S06L04Q02 480:Q72K08V06L03I02E01M01R01 481:A31S31L09K07P07D07E02M01T01

482:P81L10R03T02K01 483:Q57E21K18R01 484:D90E04A03 485:I95L04 486:D85N09Y03

487:V75I12E07L03 488:S89T07P01 490:K80R07Q04E03T01A01 491:H44L20P15V06M03Y03F02N01S01 492:V75L13S07E01I01 494:F96L03 495:A73T14G07S02V01 496:T72R15N08S03 497:I89L04M03V02 498:P84I09L03V02 499:R57P39Q01 500:N63S12T09K06P03R03D01 501:Y97F02 502:T88Q08K02

503:M82I09L07 504:S86C11 505:F87L08A02V01 506:L67Q16V09I04M01 507:P90S08 508:R86I08L02C01 (xxx) N218

1:-94M05 2:-94A05 3:-94L05 4:M94-05 5:E90-02D02G02M02A01 6:L90P05-02F01I01 7:L92S06M01 8:G93S02-01A01D01T01 9:A79G13V03-01E01I01P01 10:-97W02 ll:A71T15V07G03-02 12:T85S05- 04A03P01 13:V85L07-02A02I02 14:V82F06I05L04G01 15194V04F01 16:L85V13A01 17:-96L03

18:V87L07I04 19:C95L04 20:I90L05V03T01 21:A84S13T01V01 22:C94L03-01F01 23:-94L05 25:L97F02 26:S86F07L05 27:F73L12V06I05S01Y01 28:A75T08S05L04V03I01M01 29:A89L04S03T03 30:W98R01 31:R71K26S01T01 32:G71K15R06A02V02M01W01 33:R90K08-01 34:-97A01S01 35:-98K01 36:-94G05 37:- 96K03 38:S93R05Y01 39:G92R07 40:K89R09T01 41:-90L09 42:G95-02A01R01 43:-89G 10 44:K94R05 45:M86L13 50:A80T12S03V03I01 52:L94F04I01 54:I91L06M01V01 55:L91I08 57:N98T01

58:V57L21M13I04A03 59:L98M01 60:Q98H01 61:V83L14I02 62:K90D05N04 63:P84T14L01 64:K85S13N01 65:N85A04D04H03E02 66:L92P04M03 67:A79S09P04F02Y02L01T01 68:K94E02Q02N01 69:T87S10I01 70:L89F07Y02I01 71:Q74E08H07M06K01R01 72:K98M01 73:L96I03 74:S98G01 75:E93K03Q03 76:E83K15D01 77Ύ98Η01 79:P98S01 80:V98I01 83:V96L03 84:H87Y09W02 85:L92F03M03V01

87:S94F02L01P01T01 88:-94W05 89:D79Q09E07N03 90:P93R06 93:V98M01 95:H80Y10C06I01N01 96:G97R02 97:H71Y27S01 98:D82E13N03S01 99:V83A15L01 100:V98M01 101:K98R01 102:E97D02 105:V79I19L01 106:D93E03N02Q01 107:R90H09 108:A86G 13 109:D91E08 112:A90S09

113:A78G 14S04V02T01 115:G96A03 116:H75R08A04N03E02K02P01Q01Y01 117:M95I04 118:P94A05 119:I91V05L01M01T01 120:G87I06L05 121:D93Q04E01G01 122:R91K07L01 123:A76I 10T05V04L02 124:N91T06C01S01 125:N83K13S02G01 126:G97S02 127:L86Y06A02F02E01M01 129:I95L02V02

130:I67V32 131:F96V03 133:N98S01 134:N85G 13S01 135:E83K10N03I01T01

136:E67R13P07L06G02Q02S01 138:L85K13V01 139:Q91E07H01 140:V78L15A05G01 141:R98P01 142:R98K01 144:A72S19T07 145:L98V01 146:S62T37 147:T95A03V01 150:N96S03 156:R90K09

157:S95T03G01 158:I93V03T02M01 160:E97M01Q01 161:R96K03 163:Q97K01L01 164:E95G03D01 166:T52S26A19I01 167:E68D16Q14G01 168:Y92H06F01 169:L95F03M01 170:L86V13 171:E95Q03D01 172:E95A03D01 173:I85L07F06 174:N76S07R06T04D03K01 175:K90N04E03S02 177:K94N02Q02E01 178:G92R03E02K02 179:T71K08A07Q07M03E01 180:P92A05S02 182:D98N01 184:T97I01V01

185:F96Y02S01 186:M74L14T07I03 188:S95G04 189:C98S01 190:A85S12T02 191:V91I08 192:S98A01 194:V86I13 195:I98V01 196:C98G01 197:S96C02V01 198:I96T02L01 199:V92I06L01 201:G98A01

202:K87E05Q04N01R01 203:R96-02Q01 204:Y90F09 205:D98G01 206:Y98C01 207:K83E14Q01R01 209:K98R01 210:K92Q03N02R01T01 213:A74S14T09G01 215:M91L08

216:N82D05T03K02S02A01G01H01Y01 217:N85L08I04S01 218:M84L08I05T01 219:N97D01S01

220:N79E10S03T03D02I01 221:I90N04T03Y02 222: F97A01V01 223:E79R08Q03D02H02S02K01N01 224:M85L09F03K01 225:M75L09I04V04T03A01S01 226:N91S08 228:H53R17P12Y08I02L02F01K01S01 232:L71V28 233:Y74H21C01L01R01 234:Q60S28N10 235:M86I05L04F03 236:F97Y02 237:S73P26 238:K46N32S12R06D01Q01 239:I83L10F03V02 240:L75M24 241:D89Y06N03V01 242:Y90H08L01 243:L97F02 246:P98S01 248:N89H07Q03 249:K68N23R03Y03S01T01 250:I91M04L02V02

252:T38A25K20R06D04G03S01 253:E85N13Q01 254:F91I04V04 255:D87E12

256:A72D07K07E05S03G01I01V01 257:L98V01 259:A84D10E03N01 261:V85I 13A01 262:S70A21L03R03Y01 264:E90R07Q02 265:V96M02T01 266:K97E02 267:M39I24L16T07K03R03E02V02S01 269:Q92K04E03 270:A83E13D02G01 271:S85T13C01 272:L98R01 273:D95E03N01 274:P95C01L01T01V01

275:S75N21R01T01 276:S96C03 278:-94A05 279:Q84R14H01 281:F94Y05 282:I95V03L01 284:C96L03 285:F97Y02 287:S63N15I 12C05R02T01 288:K98R01 289:M98I01 290:Q81E15H03 291:E87Q10K01 293:K97N01Q01 294:E64D19Q13K02 295:H48N30R16C02K02 296:P95D03A01 297:N87K06S04D01 299:S79E13N02T02C01G01V01 301:H90N06Y03 302:M89E03Y03I02L02 303:K82E17 305:L97V02 306:I85V14 307:T87M 12 308:S79T19C01 309:T72A18S04V03G01 310:F90L09 311:D93N06 313:F98L01 314:I74F09L05T05S04 315:A97G01T01 316:G98R01 317:T98S01 318:E98V01 319:T95S04 320:T98I01 324:I52V26L20 326:Y97F01H01 327:G96S03 328:L95F04 330:L86I09V03 332:L96Q02I01 333:K98R01 334Ύ93Η06 335:P98L01 336:K82E09H04-02Q01 337:I96-02M01 338:Q94E03-02 339:E97-02 340:K98Q01 341:V85I14 342:Q93H06 343:E95K02Q02 347:R59Q34W03H02K01 349:V84I 15 351:R94Q05

352:S87N06D03A02 354:R59K27S13 356:C91A04S04 357:V82M 13A03L01 358:A92E07 359:D98H01 360:R97Q01W01 361:T74S12A08I02P02 362:Q84R08K06 363:M98L01 366:T98A01 368:A98T01

370:V84I13A01L01 371:H98Y01 373:I98T01 375:R98H01 377:I96L03 378:S78D09A06T04K01 379:L95I04 380:I64V31L03 381:P98S01 382:L84M07V04I02F01 383:A40G31S27 384:L92V07 386:H98R01

387:T79A16M03S01 389:T89A04I03D01N01S01 390:K85R09Q04 391:D98H01 392:T97I01V01

393:C41H 18S14P06Y05R04E02N02Q02G01T01 396:E61D23G08Q05N01 398:V72I 18T07L01 405:I91V08 406:F89Y07I03 408:I57V25L12S04A01 409:L98I01 410:S82D06T05N03A01G01 413:L98H01 414:H94Y04R01 416:S87P07E01G01K01N01 418:E91Q07A01 419:F96W03 420:P90K07L01V01 422:P96A03

423:N65E13H 13D04K01Q01S01 424:E86Q07T04A01 426:N94D04C01 428:G79E20 429:H98Y01

432:N80D09K05S03T01 433:E68K26A03D02 434:N94S04D01 435:G98S01 436:T80S16A03 438:R82K17 439:K98T01 440:S91N07T01 441:E65D27N04K01Q01 442:F85A07Y04L02 444:M92I05V01W01 445:P98L01 448:A98L01 452:I91M05V02A01 454:P83L13V03 457:G97S02 461:M98I01 463:I89L10

466:L64F27I03V03C01 467:I51L14M13T10F05V04 468:A73T18V05S02 469:T93I04A02 470:I94L05 473:N91K06H01S01 474:F98Y01 475:T98I01 476:L95F04 477:K95R04 478:P76S17A05 479:V81L13T03I02 480:V86I08E03A01 481:D73N25K01 482:P98L01 483:Q83E 10K05 484:E90D06K03 485:L83I 16

486:N69D20S09 487:I90L05V04 488:T89A03I03S03N01 489:P98A01 490:T80E10A04V02I01M01

491:L87V10M01 494:T83F13I03 495:G91S05T02F01 497:V81I 14M04 499:P83R14S02

500:A65V17P10S04T01 501:Y95F04 502:Q95K03E01 504:C97R02 505:A91F04V03L01 506:L61V24I 10F03 (xxxi) N312

1:-94M05 2:-96A03 3:-95L04 4:M98-01 5:L89E05-01D01P01V01 6:A77L06D06G04V01-01T01 7:S94-01T01 8:G94-02E01S01 9:L79M09-04A03V02I01 10:-98W01 11:L88T04-02A01I01 12:L89T04-02S02V01

13:V84L08G04-02A01 14:A75T10L04V02-02I02S01 15:L74V11I08-02A01F01 16:L83V09F03-02 17:-98L01 18:A72T09F04L04I02-02S02V01 19:C74F14Y02-02L02S02 20:L97-02 21:S45T43I02V02-02G01M01 22:V65I 16C04L04T03-02A01M01 23:-97L02 24:M76L18I01V01-01 25:V75L09I07A06-01 26:L89F03V03I02- 01 27:M77L10V08-01T01 28:S95L02-01 29:V84A05L04T02I02-01 30:W97-02 31:R59K22Q16-01 32:Q91K06- 01 33:R85-10K02 34:-98A01 35:-98K01 36:-96G03 37:-98K01 38:K85R07N02Q01-01

39:L60S10F07I06R06V06-01 40:R35W35S09L06K04Q04-01A01G01 41:-97L02 42:G90E04R01S01 43:-97G02 44:K86R08S03N01 45:L92M07 50:T94I02R01A01 51:P97A02 54:F87L08Y04 55:I93L06 58:Y89L07F02 59:L97F02 60:Q96E02 61:L98I01 62:N79D17K02 63:T90R04P02I01M01 64:E69K18Q08S02

65:Q69D10K09E04A02H02 66:M81L05I04V04P02F01 67:Y86L04S04C02F01 68:N63D14S13K06T01 69:S94C05 70:L78I 14F05Y01 71:M86T09L01S01 72:K89Q06E04 73:I68L24M05 74:S77R13G06Q01K01 75:E84K10Q04 76:R76K10H06C02L01Q01 77:Y98F01 79:P93S05L01 83:I65V34 84:H85Y13W01 85:L94M04 87:P72S10L07T07H01 88:-94W05 89:R95Q04 90:R81P15Q01T01 91:V52I46 93:V97M02

95:C81Y09W04S02T01 97:Y67H 19Q13 98:D62E35N01 99:A94V04I01 100:V95I04 101:K97R02 102:E98D01 105:V89L05I04 106:D98N01 107:Q94H04 108:A96G02 110:E95D04 112:S96G01N01 113:G98D01 114:R98- 01 115:G98A01 116:E88A05K04G01Q01 117:Q89M04I02L01N01 118:A88P06V02S01 119:T91V04F01I01 120:F83Y08L07 121:D75N 18Q02G01S01 122:W74R11T10S01 123:L82I 10V03F02 124:F95T03

125:K90Q05E02 126:G96N01E01 127:Y93F03H02 129:V94I02L02 130:A65V18T14 131:F95V01C01L01 132:S97G01R01 133:N80S15T02 134:G90W08 135:E98D01 137:A85S06W06T01 138:K93R06 139:Q91P04H03R01 140:L98-01 141:R97-01 142:R97-01 143:F98-01 144:S92A02T02-01 145:I92L06-01 146:T55A34S07-01 147:T98-01 149:R98K01 150:D91N06 153:V77M 16F04L02 157:G89S09 158:I88V10 159:E97-01 160:E97K01 161:R97-01C01 162:I98T01 163:Q90K04L02I01 165:E98K01 166:A96I01T01 167:G83Q06A04S02D01V01 168:F77Y12C10 169:L97I01F01 170:I72V17L09 171:E73K12Q10D03

172:A71M09S06T05E04V01 173:F49L45I04 174:R76Q18S02G01 175:G56K13D09S07E06A04N01T01 176:T98R01 177:R46K12N 10H10C07G05Q05 178:G98D01 179:A86T05K02N02Q01S01

180:F54P20N08L05S03A01I01T01V01C01 181:I91F06 185:F85Y06I04V02 186:F58Y37L04 187:L95M04 189:R77K13Q06C02 190:T79A16S04 191:V97I01 192:S98A01 194:V97I02 195:I94M05 196:S81N10C08 198:I98V01 202:D90E04N03Q01 205:D89E06N02 206Ύ98-01 207:E97D01 208:D96N04 209:K95E01Q01T01 210:E88Q05K04-01 211:F98L01 213:S90T04A01E01K01 216:R71Q10N05G04H04S02K01 217:M93I02L02-01 218:M86I08T02-01V01 219:L69G09T08N06M04D01 220:G74E10Q08R03V01 221:S73I 10M06T04V02Y01 222:F82N12K04 223:Q76R12K08S01 224:F95L04 225:T76A12M05V02I02 226:A89S10 227:T74S25 228:S72P21A02Y01 229:T69M14W06L03V01I01S01 230:G98-01 232:L98I01 233:Y88F05C04

234:E81D13N04 235:M89I08F01 237:Y48S28H13P07F01T01 238:S89P04G03R01A01 239:V93I04L02 241:K94D04R01 242:H74Y24 247:Q93H06 248:Q92H07 249:Q85K08E03R01 250:A80I 17V01

251:F85I09Y04L01 252:K97A01Q01 253:E69D12N11L04V01G01 254:L74M 10T06V02F02S01

255:Q72K13E08R03H01 256:G80K10E05R01 258:E89K08R01 259:D90N08 260:F96Y03 261:I86M 12V01 262:A58T17I 12V09R01 263:K78E12R06Q02 264:K93R05Q01 266:E79K13R05 267:Q69H17M05R04E03 268:N92H06 269:Q94H02R02 270:R70S14E06A04C02H01 274:P95L03 275:N96S02 276:S93A04H01 278:- 94A05 280:D77N21 281:F97Y02 284:S92C06 288:R77K10H09Q01 289:M95I02 290:Q83E05R05K02L01 291:E82Q09K05-01 292:E98-01 293:K54Q26Ell-05 294:K69N13Q07-05E01S01T01 295:N93D02H01Y01 296:P90S03V02-01 297:N90D01H01K01-01S01 298:T77S20-01 299:E95Q01-01V01 300:F98-01

301:Y57H25F06N05S02C01 302:M74L16I04Y01R01W01 303:K86R07E04Q01 306:V92L03T03 307:L49M48 308:T98S01 309:T85S10V01A01I01 310:L97F01 311:N88S10G01 314:F93I05 315:A97G02 317:T89S09 320:V92I03T03 322:T83S16 324:L89M09 326:Y94F04 327:G97S02 328:F96L04 330:L94I02V01 331:L97F02 332:M90L07Q01 333:K98R01 334:H84Y12N02 336:D69E25H04 337:V92I07 338:E84Q10A04 339:A93E06 341:V77I16L04M02 342:H92Q05R01 343:E95K01-01Q01 345:I97V02 346:D96E01N01 347:R88Q11 351:K55R44 352:N98D01 353:R97Q02 354:Q84S11H04 355:P98A01 356:K72Q16S05M04A02

357:F77Y15M06 360:R79H12K08 361:A61M20L08S04V04T01 362:K93R06 366:T90M08V01

367:E85D10Q04 371:H91N07 376:F96Y01C01 377:G66A18S08I02V02L01 378:D81N18

379:M51V14I13F12L09 380:I73A15L05V04 382:M82L16 383:G89S10 384:L69I 15V14 385:A69P28S02 386:R84H16 387:R85A04K04S04M01 388:V84I08T06 389:T78I 11N06K02 390:K92R07 391:D91N08 392:T97I02 393:K74T13H02Q02E01S01R01 394:F98L01 395:R97Q01 396:D59G25E09N04S01 397:F88Y11 398:L57F30T07I03 399:L69I30 402:G92D06 404:E88D06T02N01 405:V98-01 406:F93Y04I01-01

408:M71112L08V07 410:G92S06 412:V89L10 413:L94M05 414:R57K17T16H07N01 415:D98E01

416:P83T05R04Y02S01A01C01 417:K82R05N05S02Q01T01 418:F92Q04Y02 419:F97W01

420:S80P08K05A04 421:N74S10K06C04H01 423:Q41E16K16R12G06N03D01H01L01 424:D85A06E03T02 426:N86H09D01Y01 428:Q79K06G05E04N02R01 429:H94N05 433:E67D29R01 434:K78N16R03 436:Q92S04R02H01 437:F88L11 440:S62N33I02 441:D87A06N02P01E01 442:A94G04 444:V80M 11L04I03 448:I76L08V06A04S01T01 449:G98R01 450:K98R01 452:Y67N14F09I04M02 454:F78L21 456:E89D09 457:G93N02S02 459:A97T01 460:R92K08 462:E98Q01 465:L95I02V01 466:F94L03Y01 467:L75F24 469:T77N12I05S04A01 470:I94L02V02 471:L54M44I01 473:N97K01 475:R65H13C12T06S01 476:F89L10 477:K83R11Q05 478:S86F09P04 479:P84S06L04Q02 480:Q75K08V05L03E01M01R01

481:A32S32L09K08P08D04E01M01T01 482:P84L10T02K01 483:Q57E22K18R01 484:D90E04A04 485:I98L01 486:D85N09Y04 487:V78I09E08L02 488:S89T08P01 490:K80R07Q05E03A01T01

491:H46L17P16V06M04Y03F02N01S01 492:V76L13S06E01 494:F97L02 495:A73T15G07S02V01 496:T74R16N08 497:I93M03V02L01 498:P83I09L04V02 499:R57P41Q01 500:N65S09T09K06P03R03 501:Y97F02 502:T92Q08 503:M86L07I05 504:S90C08 505:F91L05A02 506:L69Q17V09I02M01 507:P90S08 508:R87I08L02

Table 3. Variable residues Xi - X_n, and amino acid variation at each residue, of engineered ancestral CYP4F sequences corresponding to nodes (i) - (x). For each of the ancestral sequences corresponding to nodes (i) - (x), variable residues Xi - X_n are given in sequential order. For example, for (i) NO, 391 variable residues are given: Xi - X₃₉₁. For each variable residue, the format of the data is as follows: [amino acid position] : [first amino acid variant] [percent frequency of first amino acid variant] ... [last amino acid variant] [percent frequency of last amino acid variant]. Position is given relative to the corresponding AO CYP4F sequence, as described herein Frequency is relative to all sequences used to construct all sequences used to construct the AO CYP4F sequences. Note that '-' represents a 'gap' or amino acid deletion. For example, X₇ of (i) is given as 7:S90L03V01, which sets forth that:

the amino acid position of the variant relative to the alignment to produce node CYP4F N0 A0 is '7';

the first amino acid variant is a ' S' ;

the frequency of the first amino acid variant relative to all sequences used to construct CYP4F N0 A0 is 90%;

the second amino acid variant is 'L';

the frequency of the second amino acid variant is 3%;

the last amino acid variant is 'V;

the frequency of the last amino acid variant is 1%;

) NO

:L69F23V02P01M01 2:G62R23W03S02L01F01 3:P58L13S08T04V03Q03A02H01I01M01

:V54Y18L09G04W03E03M02 5:A78T06V04S03L02I01 6:A58V19S05T05G03L01I01F01 7:S90L03V01

:P66A15S04L03G03V01T01I01M01 9:W67L23G02I01V01 10:L83H06Q03V02I01 11:L93I02T01F01

2:L68S12F04G03A02Q02V02P01 13:L84V04F03M03 14:L89V05F01M01S01 15:V46F17A15G07I06L03T016:G62F13L08V04A04I02T01S01 17:A52L17G09V07T04F03S02 18:S64F20L05T04A01C01

9:W69R19L02H01C01V01 20:L75I 10A04F03T02W01V01 21:L93V04I01 22:A67L19V06M01

3:R62Q17H06K03C02Y02A01D01G01 24:V46I25F14L05A02C01G01M01 25:L89W03F03V01

6:A57R13T13V03Q02G02S01M01K01 27:W61L14Q05F04A03R02V01I01S01

8:T48C17I 15S04V03A02R02K01 29:Y68W12H06L04R01T01F01Q01 30:T34A28R16S08H03D01V01G01K011:F75Y05L04S04H03V01A01I01 32:Y81R04H04A04C02 33:D42I 14E11N10V05W03A02T02G02R02H014:N66T19K04Y04I03 35:C66S17Y05T03A02R01 36:R65C13Q07H06S03L02 37:R88H06Q02

9:R73Q16S06C01 40:C88G07 42:P90S03L01N01R01 43:Q88E05K03 44:P97S01

6:K63R22T02G02L01S01W01M01 47:R78Q10H02P02K01 48:N83S11H03 50:F64L34I01 51:L57W35M03F014:L78Q08M06V04T01 55:G92S02D01A01 56:L49M40Q05T01I01V01 57:V32I31Y18M07A05G01S01F018:Q23T21L16P13K10H04R02S01 59:P57S33N05G01 60:T50N32S15 62:E60Q20T05K03S02A02M01R01D013:G97D01 64:L67M30 65:R31Q28K16L14S03I02V01T01 66:D17Y15L11E11V10K07N07Q04M02R02T02F01A01 67:V26L26E16T10I08F04M03S01A01

68:T45Q14K13E09D07A02S02I02 69:Q37K20E14D08S07G06H02R01 70:L70V16M07I02

71:V47L16G14A12S07I01 72:A38D15H12S06R05C04Q04T03K02N01G01

73:T57N17Y07S02H02K02A01D01R01Q01 74:Y51F30M14L01 75:P32R21H18G11S10K03T01

76:Q33D31H24R02K01P01Y01 77:G40V37A05S05I04M03 78:F38C20H12I11Y06L03V02Q02

79:L46C15K10M09V05R05S03T03 80:W32V23I11T10C05M04L03R02S01F01A01 81:W94F04

82:M40L22V16I11F07G01A01 84:P98A01 85:I32F21V21W15T04L01M01A01

86:L22I18Y17F14H10T04V03Q02S01C01 87:P82A11H03S01 88:L33I29V24F07M03 89:L37I35V25

90:R37V24T11I10S06H04N03 91172114F10V02 92:C39V30F22I02Y01 93:H95D03L01 94:P98S01

95:D63T12K08N06A04S03 96:Y30F20I17T11M06L06C05V01 97:I71V21L05A01 98:R41K40A16

99:P63S26T05I01 100:V53L28I15F01 101:L57T14I10V09A06 102:N31G14Q14S13F10L06M03T02H01 103:A96T02 104:S70P29 105:A94D02V02 106:A74T09S05L03N02F01 107:I60V32L03A01T01

108:A79T08V07I03 109:P84L04V03D02 111:D90E04N03 112:M31D17K16V13E10A02I01T01Y01

113:L32V26F14I14T08D01 114:F89S03L02I02 115:Y91I04L02 116:G41S32R11N04D03K03E01T01

117:F87H03T02M01L01V01P01 118:L97M01 119:K83R08E06 120:P98L01 124:D86E08Q02N01 125:G95S03 126:L94I05 127:L95F03 128:L88V05I03M01 130:A51K16G09N07S06R02T01D01V01 132:D83E10N02Q01 133:K93E03R01 135:S86R04A02G02N01 136:R69H15S10Q02W01 137:H93R02K02 139:R94H04 140:M55L43 146:H98R01 148:N53D38E05K01 151:K98R01 152:P86S06N05 154:M52V35I10L01 155:K92A01T01 156:I93T02V01 158:N85T11S03 159:K36Q25D15E14S02T01G01 160:S82C16 161:T41V32A24

162:N59D31T02K02E01 163:I85V08T05 164:M97L02 165:H91L08 166:A79D12G02N01T01V01

169:Q58R23K10E02H02L01 170:R72H11L09C02A01 171:L96A01 172:A62V14I10T06C02G01S01

173:S47A13E12T09L08K01Q01 174:E59G24K05Q05A01 175:G82S13P01 176:S59V12H10T04P03N03E02 177:A40T33V14S06I01N01 178:R54S21H14C03N03 179:L93F02I01 180:D89E08N02 181:M96V02 182:F97L01 183:E93D02Q01 184:H89N06Q01 185:I75V21L03 186:S96T02 188:M93L06 189:T98A01 192:S92T04I01 194:Q93L06 195:K98R01 197:V74I15A03L03T03 199:S95G03 200:F61Y32H03I01 201:D67N23E06

203:N68H23D06K01 207:K72S12R08N03H01Q01 208:P75M15S05N01T01 210:E71D23K02 212:I96V02 213:A68S24T03D01 214:A89T08S01 216:L74I16M03V02Y02 217:E97D01 220:A78S14D03T02 221:L98F01 222:V78I15A03S01 223:V36A27E09T09S08I05M01 224:K72R21D02E01Q01 225:R98K01

226:H35Q24N14S07Y05R03E02T01I01 227:Q53Y16H11E05R04F02N01L01 228:Q54R22H07K05E03Y02N01 229:I47L38F05P05V02 230:L40F35H17P03S01 231:L63H24Q07M01V01 232:H60Y33Q02F02

233:M31I 18L16V08W07T04P03K03F02A01 234:D96N01 235:F78W07L07S03C01 236:L72I22V02F01 238:Y69H10F05W04R03N03Q01 239:L83R13K02 240:T91S08 241:P45A23S10H07Q05C02R01E01

242:D82N05Q04E03C02 244:R58Q26W05M05K03 245:R95C01H01 247:R78H05K04L02Y01S01A01C01Q01 248:R57K21Q17E01 250:C96L03 251:R51D31N05H03S02A01E01K01 252:L68T16I07V04M02

255:D54N13R11H09K03S02E01A01 257:T98S01 258:D68T16A06R03G02 259:A69E17D07N01G01T01 260:V95I03A01 261:I90V09 262:Q88R10 263:E84K05Q03R02D01 265:R95H02

266:R75Q06H05A03C03L01K01 267:T66A22L03I02Q01 268:L97I02

269:P46S12R10N05A05H04T04I03Q01D01C01L01 270:S40Q20T10D08K06E04N03H02R01 271:Q77E08L05H02K02 272:G84D04S04N03R02 273:V35I20A17S06T05G02L02H02R01P01M01

274:D61E26H03Q03G01N01 275:D60A23E09S02T01 276:F64W22V03L02S01D01 277:L90I02F01V01 278:K73Q16T02R01E01 279:A66S11D06T04G03N02 280:K92A02R01 281:A61-26T05E02R01V01

282:K71Q23R02P01 283:S40G23T16A11Q02 284:K96R03 285:T92K02V01S01 286:L87M05K04V01 289:I95V03 291:V91I05L03 292197102 294:L96M02 295:S41A38T18 296:K87R10E01 298:E94K04

299:D79H08N07E03 301:K87Q04N03R01H01 302:E52G18A08K07Q04T02R01P01 304:S93T06 305:D97N02 306:E96K02 307:D94E04 308:I96V01M01 309:R89Q04A02K01 312:A98V01 313:D96N03 318:E64G20A13R01 324:A83S16 326:G91A08 327192107 328:S95C02A01 330:V68I19A04T04L01 331198F01 332:Y83F16 333:N84H15 336:K55R36Q04C01 337:H83Y15 338:P94Q02 339:E93H03K01 340Ύ95Η03 342:E93D04 343:R72K21Q03H01 346:Q75E18K03A01 348:V76I22 349:Q79R11M03T01K01N01 350:E87D09Q01 351182V15I02 352180M 19 353:K50R39Q04E02G01A01 354:D65G32N02 355:R95K02 356:E79D15Q02 357:P59L16S11T06G02V01 358:K41E38Q07D02H02T02I01V01 359:E93D03N01 360:I81L17 361:E95D02 363:D86E12 364:D98E01 366:A69T16S11V01 367:Q90N04L01H01 368193M06 371172T23I02

375:I87L08V02M01 376:K98R01 381183Q14 382:H81F14Y04 383:P94S05 385:V90A08

386:T57P26S04Q03I02V02A01L01 387:V36A20L16F06M03D03T03I02S02G01R01 388:I62V32L03

389:S84T07L02A02V01 391:R41C39H07G03S02K02Q01Y01 392:C88Y05V04 393:T93A02I01S01

394:Q73E22K02 396:I68V22T04M03 397:V56K21A03T03L02G02E02M01Q01P01S01 398196M01V01 399:P98R01 400:D93G04 401:G94S02D02 402:R95L01K01 403:V75I20T03 404:I95V03 406:K96Q02 408:V39I30N24S02T01A01 409:I77T08V08D01A01 411162V16I07H02M02S02T01R01 412:I71V21L05M01 413:S82N14D03 414:I87V11L01 415:F61Y26I06L03T01 416:G95A04 417:T66I19V10L01M01 419:H93Y06 422:S37T31A21L02E02D01Y01 423:V96I02 425:P92T03Q01R01 426:D86N08E04 427:P83S15A01

428:E76K16H03Q02D01 429:V96E02 430:Y91F08 431:D65N34 433:F65Y22L06H01S01M01

436:D89E04S01N01Y01 437:P90Q03S01A01L01 438:E75D15T02K01N01A01 439:N89T03K03A01

440:I35P30S18T05V02L02A02 441:K52Q42E02 442:E28K24Q17G16D08S02N01 443:R94Q02I01 444:S97P01 445:P92S07 446188H05M02V01 447:A96S02 448:F87Y12 449:I76V20M02 453:A92S03V03 455:P97S01 462:T49S21A15N07K04 465:M95L04 466:A58T24N09S06 468:M91L05I02 469:K80R19 470:V94T03I01 471:V69A27I02 472175V23 473:A96G03 475:T94M04 477194R01Y01 478:R90H08 480:R93A01V01 481:V56L23I12F07 482171S15R05T04F01 483:P75V16L04C01 484:D88G06T02 485:H24D19R16E14K04- 04P03A02G02L01N01S01 486:T45E16K14A07S05R03H01P01 487:E71R17K03G02P02 488:P75K17V02T01 489:-74V24 490:R92C03L01 492:K86L05Q04T02 493:P95S02 494:E94Q04 495194I04V01 496:I80V18 497195M04 499:A79T18S01 501:G70N19D07S01 503183116 506:R67N12Q11K04H01L01 507:V86L09M04 509:P93L03E01 510197V01 511:S54P15N12G07K01R01L01 512:A32P18-15T14S04G03V02E01Q01R01 513:G38-19R15S04P04Q04N04D02E01V01L01 514:A26-22P18Q11L06S06T03G01 515:Q45- 41S02P02R01A01L01

(ii) N4

1174F20P01M01 2:G68R22W03S01 3:P64L14S05Q04V02A02T02H01I01 4:V58Y17L08G04E03M03T01 5:A83V05T04L02S02 6:A64V19T06S04L01I01G01 7:S97F01 8:P73A12L03G02V02S01T01M01

9:W75L19G02I01 10186H07Q03 11195102 12172S13F04G03V02P01A01 13189M03F02V01P01 14:L95V02F01 15:V52F19A11I06G05L02T01 16:G69F14V05A03L03I01S01 17:A57L14G08V07T04F03S02 18:S72F19T05A01 19:W77R17C01H01L01 20:L82I11F03 21:L97V01 22:A75L16V03M01

23:R68Q17H07C02Y02K01 24:V49I28F15L02C01G01 25:L96F02 26:A63R14T10Q02V01M01K01S01 27:W68L14Q06F02R02I01 28:T54C17I16S04A02V02 29:Y74W13H04R02F01C01Q01

30:T38A30R11S09H03D01K01G01V01 31:F81L05S04Y02V01A01I01 32:Y87H04C02R02

33:D47I14E12N11V03T02G02R01H01A01S01 34:N69T19K05I03Y01 35:C69S19Y05V01

36:R68C14Q04H03S03L02A01 37:R90H07Q01 39:R75Q18S03C01 40:C89G08 42:P95L02R01 43:Q96E02 44:P96S01A01 46:K70R20G02S01L01 47:R79Q10P02H02K01W01 48:N86S08H04 50:F70L27I01

51:L54W39M02F01 54:L79Q09M06V04 55:G91S02D02A01 56:L52M40Q02T01I01V01

57:V35I32Y20A05M03S01 58:T23Q20L18P14K10H05S01R01 59:P61S31N04G01 60:T46N35S16

62:E55Q22T05K03S03A03M01R01D01 63:G97D01 64:L66M31V01 65:R34Q25K18L14S03I02

66:D19Y17L13V11E10N08K07M03F02T01R01G01 67:L29V19E18T11I09F04M03S01A01

68:T50Q16K14E10I02A02S01 69:Q39K21E12D08S06G06H02R01 70:L69V18M08I02 71:V43L18G16A13S08 72:A39D17H13S06R05C04T03K02N02Q01G01 73:T57N19Y08S03H02K02D01A01 74:Y49F31M16

75:P35H20R20G12S09 76:Q36D35H19R02K01E01 77:G43V41I05A04M03 78:F39C15H14I12Y07L03V03Q02 79:L45C15K12M10V06R05T03 80:W27V26I13T08C05M04L04R02S02F02A01 81:W98C01

82:M41L21V17I11F06A01 84:P97A01 85:I34V23F15W14T05L02M01A01

86:L21I20F15Y13H12T05V03Q02S01C01 87:P86A12 88:L33I29V25F07M03 89:I39L38V21

90:R33V27T12I11H04S04N03K01 91:L71I15F11 92:C44V31F16I02Y01 93:H94D03L01 94:P98S01

95:D61T14K08N06A05S02 96:Y26F22I19T09M07L06C06V01 97:I75V19L03A01 98:R44K35A17

99:P60S28T06I01N01 100:V55L26I 16F01 101:L55T15I 11V09A07 102:N34G16Q15S13F11L04H02 103:A96T03 104:S70P29 105:A94D02V02 106:A79T10L03S02N01 107:I59V34L03A01T01 108:A82V08T04I04

109:P89L04D02 111:D89E05N04 112:M35D19K15V15E05A02I02T02 113:V28L27F14I14T09D01

114:F92S03L02 115:Y90I05L02 116:S35G35R12N05K03D03E02T01 117:F89T03M01V01L01P01 118:L97M01 119:K88E07R03 120:P97L02 124:D91E06 126:L94I05 127:L95F03 128:L89V06M01I01

130:A57K18G10S05T01N01R01V01D01 132:D91E05N02 135:S91R05N01 136:R66H17S11Q01W01

137:H97R01 139:R93H05 140:M59L40 146:H98R01 148:N59D31E06K01 152:P92S05 154:M56V33I09 155:K97T01 156:I96V01 158:N83T12S03 159:K40Q22D17E15G01 160:S80C18 161:T35V35A27

162:N61D29T03E02K02G01 163:I89V07T02 165:H93L06 166:A81D11G02V01T01 169:Q64R18K11E02L01H01 170:R72H12L10C03 171:L97Q01 172:A65I11V10T05C02G01S01 173:S52E13L09T09A07K02Q01I01

174:E61G25K05Q05 175:G80S15P01A01 176:S64V14H11N03E01T01 177:A45T31V13S07I01N01

178:R60S19H15C03 179:L97F02 180:D93E04N02 181:M98V01 182:F98S01 184:H92N06 185:I79V17L02 188:M95L04 189:T98A01 192:S94T02I01 195:K98R01 197:V79I15L03 199:S95G04 200:F67Y27I01H01 201:D71N21E06 203:N68H23D05K01 207:K76S09R08N03H01 208:P78M17S02N01 210:E72D21K02A01 213:A71S22T03D01 214:A88T09S01 216:L77I18M02 217:E97D01 220:A86S10T01 221:L98F01

222:V80I14A03S01 223:V34A30E10S09T09M01I01 224:K78R19 225:R98K01

226:H39Q22N16S08Y06T01I01A01 227:Q58Y18H07E06R04N01L01 228:Q60R19H08K04E03

229:I48L37F05P04V02 230:F39L37H19S01P01 231:L68H18Q07M02V01 232:H57Y37F02Q01 233:M35I 19L18V09T04K03P03W02A01F01 234:D98N01 235:F85L08S04 236177118V02F01

238:Y74H11F06R02N02Q01 239:L86R11 240:T94S05 241:P48A24H08S07Q04C02R01

242:D88N05C02E02Q01 244:R57Q28W06M05H01 245:R96C01H01 247:R83H05L03Y02S02C01

248:R59K22Q15E01 251:R57D31N05H03E01 252:L75T14I05M02V01 255:D61N14H08R07K02S02E01 257:T98S01 258:D76T18G02 259:A77E17D01 260:V95I03A01 262:Q87R12 263:E92K02D02A01 265:R97H02 266:R82H05Q04C03L01 267:T73A19I03S01 269:P51R10S10A05H04T04I04N04C01V01

270:S44Q17T12D09K07N03E02 271:Q81E09H02L02K01G01 272:G85D04S04N03

273:V39I23A18S07T02G02L02 274:D68E23H04Q01G01 275:D67A20E09 276:F71W18V04L02

277:L94F01I01V01 278:K77Q18R01E01 279:A73S09D07N03T02G02 280:K98R01 281:A67- 18T05E02V01G01R01 282:K78Q19R01 283:S45G20T18A12V01 286:L96M02 291:V98I01 294:L97M02 295:S40A39T18 296:K86R11E01 298:E94K05 299:D80H09N07E02 301:K96N01R01

302:E57G 15A09K08Q04R01P01 304:S97T02 305:D97N02 306:E96K02 308:I98V01 309:R98Q01

318:E65G22A10R01 324:A81S17 326:G94A05 327:L96I03 330:V71I20A04T01M01 332:Y81F18 333:N83H16 336:K61R34Q03 337:H82Y17 338:P97Q02 340Ύ95Η02 342:E95D03 343:R77K18H02 346:Q78E17K03 348:V77I20 349:Q84R12 350:E91D05Q01 351:L80V16I02 352:L82M 16 353:K54R42G01 354:D69G27N02 356:E85D09Q02 357:P66L17S11T02 358:K45E37Q07D02T02I02V01 359:E96D01N01 360:I82L16 361:E96D02 363:D94E05 366:A76T18S01V01 367:Q95H01L01 368:L95M04 371:L81T15I02 373:M98L01

375:I86L09V02M01 381:L82Q16 382:H79F16Y04 383:P98S01 385:V89A09 386:T57P29S04I03V02A01L01 387:V40L18A12F07M04D03T03I03S02G01R01 388:I67V26L03 389:S88T02L02A02V01

391:C43R38H08G03S02Q01Y01 392:C92V05Y01 393:T94A02I01 394:Q77E18K02 396:I71V22T05

397:V62K18L03G02A02M02Q01T01E01S01 401:G97S02 403:V77I21 408:V40I33N23S01T01

409:I77T09V08D01A01 411:L58V18I08H03M02S02T02R01F01 412:I74V19L05 413:S80N15D03 414:I87V12 415:F67Y18I06L03T01V01 416:G94A05 417:T63I21V11L01M01 419:H93Y06 422:S41T32A19L02Y01 423:V98I01 425:P94Q01R01 426:D94N04 427:P81S16A01 428:E81K18 430:Y95F04 431:D67N32

433:F73Y22L02S01 436:D91E03N01Y01 437:P90Q03S02A01L01 438:E77D17K02N02 439:N89T04K03A01 440:I38P33S14T04V02A02L01 441:K52Q44E01 442:E30K27Q18G 13D09 443:R97I01 444:S98P01 445:P98S01 446:L95M02V01 447:A98S01 448:F85Y14 449:I79V18M01 453:A95V04 455:P97S01 462:T54S22A17N03 465:M97L02 466:A54T26N10S07 468:M96I02 469:K82R17 470:V94T04 471:V67A29I03 472:L80V19 473:A96G02 475:T94M04L01 478:R90H08 481:V57L20I13F08 482:L79S17F01 483:P79V18C01

484:D92T02G02A01 485:H27D21R18E12-05K05A01G01L01N01S01 486:T49E18K16A07R03H01L01

487:E78R16K01P01 488:P79K17V01 489:-81V18 490:R92C04L01 492:K90Q04T02L01 493:P96S02

495:L93I04V01 496:I82V15T01 497:L94M05 499:A78T20 501:G73N17D06S02 503:L82I 17

506:R74N14K04Q04 507:V91M04L03 509:P95L03 511:S60P17N09G07L01R01 512:A34P18-17T15S04V02G02 513:G43-19R16N04Q04S03D03P02L01 514:A28-21P19Q11L07S05T03G01 515:Q50-38S02P02R01A01H01K01 (iii) N9

1:L93F05 2:G86R07W02S02 3:P84L07Q04T01H01S01 4:V77L07E06M05G02 5:A88S03V03T02E01

6:A77T10V06S04 7:S97F01 8:P96A02L01 9:W91G06L02 10:L94Q03T01 11:L98T01 12:L92F03P02V02 13:L85M08F02V02 14:L92V05F01 15:V79A08I07L02T01 16:G87V08L02A01 17:A66G 17V07T05L01 18:S92F02L01T01 19:W98R01 20:L85I 12F02 22:A94L01T01V01 23:R82H11C04Q01 24:V66I26C03L02F01 26:A78T12M03R01V01I01S01 27:W86Q10F02 28:T80I12S03A01V01 29:Y93F02H02C01 30:T68A23R03S02I01 31:F77S10L07A02I01 32:Y95R01H01L01 33:D55N24E06G04H02R02I01A01S01 34:N86K06T04I02

35:C56S25Y10F01V01R01N01 36:R84C05H04Q02L02 37:R81H15L01 39:R61Q33C03 40:C82G 15D01 42:P94L04 45:P98R01 46:K94R02M02 47:R67Q21H04P02L02W01 48:N92S05H02 50:F92L07

51:L48W46M02F01 52:G97A01S01 53:H98Q01 54:L70Q15M08V04 55:G93D02N01Y01 56:L69M22Q05V01 57:V59I27Y04S03A02 58:T48P31Q05K05N02S02A01G01R01 59:P86S12N01 60:T94S04 62:E51Q45K02 64:L55M41V02 65:R44K35S07I04L04Q03 66:V25E19K16N14Y08D05T04G02Q01F01

67:L58V17F10S04T04M03 68:T89Q04I03D01 69:Q80E07K04G03R02 70:L85M08I04 71:V74S13A10

72:A83T06S04G01R01V01 73:T76N17K04 74:Y96F02H01 75:P72S19G04R02T01 76:Q76H05R05D04K02P01 77:G91A03V02S01 78:F79Y13C04 79:K25M22L15R12V12T07C03 80:I28V20T18M07W07L06R05F03K01 81:W96C02 82:M57L29F07V02I02 85:I66T10V07F03W03M03A03 86:I33F29T10V07L07H03Y02S02M01 87:P94A04 88:I32L29F16V13M07 89:I66V18L14 90:T23I23V19R12S09N07H03 91:L69F25I04 92:C89F05Y04 94:P96S03 95:D87N07T04 96:I40T19M15L14C03Y02F02V01 97:I73V17L07 98:R91K07Q01

99:S61P16T12I03N02A01F01 100:V65I30F03 101:T31L24I23A16V03 102:N71S21F04L01 103:A93T06 104:S94P05 105:A91D06V01 106:A88T07N01S01E01 107:I60V29L04A02T02 108:A82T08V08

109:P82L07D06V01 111:D87N07E03 112:M29V27K15D10A05I04E03-01L01

113:V33I28L22F08D01H01Q01T01 114:F91S05L01 115Ύ85Ι 11Τ01 116:S34R17G 16K08D07N07E03T02 117:F83T07M04V03I01 119:K92E05R01 124:D85E14 126:L86I 13 127:L97I01 128:L88V11 129:S97T01 130:A69G20N03V02D01 131:G96A01V01 132:D97E02 135:S89R07N02 136:R61H20S16Q01 137:H98R01 139:R93H04S01 140:M91L07 146:H96R03 148:N96D02 152:P93S04H01 154:M53V24I21 155:K95T02R01 158:N73T22S04 159:K52D25E17Q02H01 161:V40A34T24 162:N66D20T06E04K01 163:I93V06 165:H86L13 166:A74D21T02G01V01 169:Q79K08E06L03R02 170:R65H20L12 172:A60I20V16T02

173:S66T17L05K03I02A02M02 174:E82G 11Q04 176:S72H23N01T01 177:T48A33S15N01D01

178:R66H26C04S01N01 180:D97N02 181:M97V02 182:F97S02 184:H91N07 185:I91L04V04 188:M93L06 189:T97A02 192:S95T03 193:L98V01 194:Q98L01 195:K97R02 197:V74I24T01 199:S98N01

200:F79Y15I03L01 201:D88E06N04 203:N61H34R02D01K01 207:K84R15 208:P94S05 210:E89D06K03 213:A92S04T03 214:A78T20G01 215:I98V01 216:L93M05 218:L98I01 220:A94S02E01T01 221:L96F03 222:V87I11 223:A37E22S15V14T07D01R01 224:K96R01E01 226:H37N29S13Y08Q03V02T01D01

227:Q75H10E07L02R01N01 228:Q69H 13E06K03R03D02Y01 229:I65L17F09P04V02 230:L55F39S02P02 231:L77Q14M02V02H01R01 232:H65Y31F01N01 233:M51I 17K07T06L05V04P03F01 235:F81L11S05W01 236:L94V03I01 238:Y67H 11F10R05Q03N01 240:T95S04 241:P66H11Q09S08L01 242:D86C05N03E03 244:R49Q31W09M08 245:R96C02H01 247:R78H10L06Y03 248:R75K21N01 249:A98V01

251:R88H04D02N02K01 252:L97I01 255:D87N07E02H01K01 258:D91G05A02 259:A93V02D01S01

260:V95I02A01 261:I98V01 262:Q94R05 263:E93D03K01R01 265:R94H04 266:R86H05C04Q02N01 267:T95A02S01 269:P87T03S02A01N01L01R01 270:S44T24K12D11Q02E01-01 271:Q69E21H04K02D01 272:G79D09N06S02H01 273:I43V40L05G04T02A02E01 274:D92E05G02 275:D96A01E01

276:F88V06L02W01 277:L94I03F02 278:K77Q21 279:A72D14N06S03T01 281:A87E05T02V02-01 282:K95E01Q01R01 283:S58T30A05V02G02 286:L97M01 288:F98I01 295:S59T35A03I01 296:K97E01 298:E93K06 299:D93N06 301:K97N01R01 302:E42G24A15K09Q03R02P01 308:I98V01 312:A98V01 318:E68A15G 13R03 327:L98I01 330:V75I23 333:N75H24 336:K59R37Q03 338:P98Q01 340Ύ97Η02 343:R94H01Q01C01 346:Q95K01E01 348:V95I01A01E01 349:Q86R10H01K01 350:E90D07Q01

353:K57R40G01 354:D93G05 355:R97C01 356:E84D13K01 357:P74S22T02A01 358:K69E12T05I04Q03V03L01 359:E95N03 363:D96E03 366:A95N02S01 367:Q96K01 371:L98T01 375:I77L15V05M01 382:H95Y04 385:V82A16I01 386:P49T45S02A01V01 387:V49F16A14T05S04M03G03I02 388:I81V15F02

389:S92T05A01F01 390:R98H01 391:C44R34H12G05S01Y01 392:C89V06Y02 393:T95A03 394:Q98E01 395:D98N01 396:I74V13T10 397:V74G04L03M03E03T03S02K02A01 400:D97N01 401:G94S05 402:R98W01 403:V91I06T01 408:V60I27N 11 409:I71V13T13A01 411:L61V14I 10S05H03M02F01N01 412:I92L05V01 413:S60N31D07 414:I85V14 415:F74I 15L04T02V02Y01 416:G88A11 417:T65I17V11M03L02 419:H96Y03 422:S42T35A17Y02L01 425:P92Q03R02 426:D97N02 427:P98A01 430:Y96F03 431:D92N07

433:F86L05Y05S01 436:D86E06Y03K02H01 437:P90Q07L01 438:E95K02D01 439:N97K02

440:I68S20T04V03A02P01 441:K85Q14 442:E48G23D13K11A01 443:R98S01 445:P97S02 446:L89M06V03 447:A98S01 449:I93V06 453:A96V02 462:T55A31S07N02V02K01 465:M98L01 466:A52T34N10S02

468:M97I02 470:V89T09A01 471:V80A12I06 472:L97V02 473:A96G03 475:T87M 10L02 478:R82H17 480:R97L01 481:V60I 19F17L02 482:L98R01 483:P98C01 484:D87T05G03A01V01 485:H44D16E12- 09K09G01N01P01 486:T43E26K15R06A03L02D01P01 487:E97R01 489:-98V01 490:R87C09H01

492:K88T06Q03L01 493:P97R01 495:L92I06V01 496:I78V19T02 497:L89M 10 499:A92T06 501:G91D06N01 506:R92Q04H01 507:V90M06L02 509:P93L05 511:S65N17G13R01K01 512:A42-22T18V06P04S03G01 513:G54-22N07Q06S05P02 514:-25Q22P19L14A07S06T01G01 515:Q66-28S02K01R01

(iv) N10

1:L87F10 2:G85R06S04W03 3:P78L12Q05T03 4:V60L14E12M07G03 5:A80S07V06T03E01 6:A87S07T03V01 7:S95F03 8:P94A03L01S01 9:W96L03 10:L91Q05T01 11:L98T01 12:L85F06V03P03 13:L85F04V04M03 14:L89V07F03 15:V70A12I08L04T03F01 16:G94L03 17:A85V08L02T01 18:S87F05L03T03A01 19:W96R03 20:L72I22F03A01 22:A92L03T02V01 23:R79H16Q03 24:V60I27C06L03F01 26:A71T19R03I01S01V01 27:W75Q19F03R01 28:T68I 19S06V01C01L01 29:Y88F05H03C01 30:T75A10R05S04I02

31:F60S18L11A04I01Y01 32:Y93H01L01R01 33:N39D29E10G08R04I03A01S01 34:N75K10T08I04

35:S41C35Y16V03F02A01 36:R75C08H05Q05L03S01 37:R77H18L03 39:R67Q23C07 40:C75G20D01 42:P91L07 46:K91R04M02 47:R76H08P05Q03L01W01C01 48:N91S06 50:F87L12 51:L63W28M05F03 52:G94A03S01 53:H98Q01 54:L73M 15V08Q01 55:G88D05N03Y03 56:L57M32Q08T01 57:V57I22Y08S07A01 58:P56T25Q10R02S01K01 59:P83S14N01 60:T91S07 62:Q71E23K04 64:L60M38 65:R37K26S13I07L07Q05T01 66:E29K21Y15D09V08G04Q02T02F01N01 67:L39V29F13T07M05S03 68:T85Q08D01I01A01S01

69:Q64E13K08G07R03D01 70:L88M09 71:V78A19M01 72:A72S08T08G02R01V01K01N01 73:T57N31K08I01 74:Y95F04 75:P73S11G08R05T01 76:Q69D08H07R07K03N01S01 77:G86A07V05 78:F62Y25C08L01S01 79:M33L28R13V10C07K06 80:T33I28M 13W13V06L03 81:W94C04 82:M50L26F14V05I03

85:I62W07F06M06V06T05A04 86:I26T15V14L12F10H07Y05M02S02R01 87:P90A08 88:I43L30M 13V07F03 89:I67V30L01 90:T32I30V14R10H05S03N01 91:L55F35I07 92:C87F10V01 94:P93S05 95:D90T07 96:I30M29L21C05Y04F03T03V01 97:I67V17L13 98:R83K13Q02 99:S42T23P17I07N04A01F01 100:V76I 16F05 101:L43A30T17V06I01 102:N64S23F07L01G01 104:S90P09 105:A97V01 106:A88T04S02E01N01

107:I54V39A04T01 108:A96T02 109:P82L13V01S01 111:D77N14E05G01 112:V45M35A07K03-02L01D01E01 113:I43V32L08D03F03H03Q03T01 114:F96L02 116:S39G15D14N14E07T04K03R01 117:F80T08V07I01 119:K97R02 124:D98E01 128:L78V21 130:A88G03N03D01K01 132:D95E03N01 135:S94N03 136:R64S31H03 139:R90H07S01 140:M86L12 148:N93D05S01 152:P92S03H01 154:M58V37I03 155:K96R03 158:N57T41 159:K44D42E05Q03H01G01 161:T42A35V22 162:N51D37E08K01 163:I87V11 166:A94T03

169:Q62K16E12L05R03 170:R84H14 171:L98M01 172:I37V30A28T02 173:S51T32K07I04A03

174:E73G 15Q08D01K01 176:S51H43N01T01 177:T76A16N02D01S01 178:H48R43C03S03N01 180:D98N01 181:M98V01 184:H85N14 185:I89V07L03 188:M87L12 192:S91T07 194:Q98L01 197:V94I04T01

200:F69Y28L01 201:D89N08 203:N92H03D01K01 207:K97R01 208:P93S05 209:S98N01 210:E82D11K05 213:A87S07T05 214:A91T06G01 215:I97V02 216:L98Y01 220:A92E03S01T01 222:V96A01

223:A59S15V14T08R01 224:K94R02E01 226:H41N25Y16Q07V03D01E01S01 227:Q74E14H07R03D01 228:Q89E07R01Y01 229:I62L27P07V02 230:F51L40S05P01 231:L89M04H03V02 232:H78Y16N02F01 233:M64I08L08V07T03F01K01 235:F66L20S09W02 236196103 238:Y55H17R09F07Q05N02 240:T97S02 241:P75S16H03L03A01 242:D92N04E02 243:G98W01 244:R44Q21M 16W16K01 245:R93C04H01

247:R77H11Y06L01 248:R58K37N03E01 249:A96V02 251:R85N05D04K02H01 252:L96I03

255:D80N09E03H01K01R01 258:D84G09A03S01 259:A89V03D03S03 260:V92I03A03 261:I97V02

262:Q94R04 263:E89D05K01R01 265:R89H08 266:R77H08C07Q03N01 267:T91A04S01

269:P88S04N03L02A01 270:S42K22D21Q03E03-02T01 271:Q44E39H08K05D01 272:G66D14N11S03H03 273:I36V34L10G07T04A03E01 274:D90E05G03 275:D93A03E02 276:F79V11L04W02I01 277:L92I07 279:A88S07T02 281:A77E 10V03T03-02R01 282:K91E03Q02R02 283:T54S26A09V04G03 285:T98V01 286:L96M03 288:F98I01 295:T65S25A06I02 298:E98K01 301:K98N01 302:G44E42Q07R03A01 312:A98V01 318:E85R06A05G02 327:L97I02 330:V56I41A01 333:N97H02 336:K73R26 338:P96Q03 340Ύ96Η03 343:R97H01K01 346:Q93E02K02 348:V96I03 349:Q82R13H01 350:E83D14Q02 353:R72K23G01Q01 354:D89G09 356:E92D04 357:P54S42T03 358:K59E20T09Q07L01 359:E91N07D01 363:D96E03

366:A91N03S03T01 368:L98M01 371:L97T02 375:I98L01 379:L98M01 384:P97-01S01 385:V98A01 386:T83P05S05A02V01 387:V69S08A06M06G05I03 388:I83V14 389:S96F01A01 390:R98H01

391:R48C46S03Y01 392:C94Y04 393:T96A01S01 394:Q96E03 395:D98N01 396:I73T16V09

397:V56G07L07M07T05S05K03E03A01 400:D95N03 402:R98W01 403:V91I05T01 404:I98V01

408:V92N04I03 409:I74V14T09N01 411:L76I 13V05F02 412:I94L02V02 413:S69N16D14 415:F92V03Y03 416:G92A07 417:T91I07 422:S65T14A12Y05L01 425:P88Q05R05 426:D96N03 427:P98A01 430:Y92F07 431:D87N12 433:F82L10Y03S02 436:D82E11K03H01 437:P93L03Q03 440:I82S07V03T03P01 441:K86Q12 442:G40D24E24K05A01N01Q01 443:R98S01 445:P96S03 446:L92V06H01 447:A97S02 449:I87V12 453:A94V05 462:T89S06N03 465:M98L01 466:T64N 18A12S04 468:M98I01 471:V65A22I 12 472:L95V04 478:R98H01 480:R98L01 481:V78I 13L05F03 482:L97R01 483:P98C01 484:D89G05A03V01 485:D31E23K17- 16G03N02P01H01 486:E48K28T14A05D01 487:E96R02K01 488:P98V01 489:-97V02 490:R82C12H02L01 492:K92Q05 493:P96R03 494:E98Q01 495:L97I01 496:I98V01 497:L96M03 499:A90T08S01 501:G95N03D01 506:R91Q08 507:V85M 11L03 509:P89L10 511:S94N02G01 512:A51T29P07S05G03 513:G70Q11S09P03- 01R01 514:Q41P30A14-06T03L01 515:Q80-09S03K03R01H01

(v) N 105

1:L85F14 2:G79R14S02T02 3:P85T11S02 4:V97L02 5:A97T02 6:A85S08V05 8:P79A14L02S02 9:W82L17 10:L97Q02 12:L97P02 13:L94V05 15:V82A17 16:G82L17 17:A47G32L11S02T02V02 18:S85F14 19:W85R14 20:L94A05 22:A85L14 23:R79Q11H08 24:V82L17 26:A73R14T11 27:W82F17 28:T79V08C05A02L02 29:Y79H14C02L02 30:T70R17A11 31:F97Y02 32:Y88R08A02 33:D79I 14G02R02 35:C94A05 36:R94C02H02 37:R58H41 38:L97I02 39:Q55R41K02 40:C97G02 42:P97A02 46:K82R17 47:Q52R38L08 48:N91S08 50:F82L17 51:W70L29 54:Q61L35M02 56:L88M08Q02 57:V58I26A08L02M02 58:T76Q17K05 59:P91N08 60:T97N02 64:M52L26V20 65:K64Q17R17 66:K41E32T20A02L02 67:L38V35F26 68:T73I 17D08 69:Q97E02 70:L97M02 72:A76T17K05 74:Y82F17 75:P76R23 76:Q73H14D08K02 77:G67S11V11A08 78:F91C08 79:K70L23M02S02 80:L35F26W23V14 82:M55L44 85:T58F23I 11A05 86:F76Y14L08 87:P97S02 88:L52I38F08 89:L70I23V05 90:I38T38R23 92:C85F08V05 96:I41T35Y17F05 97:I82V17 98:R82K17 99:P79S20 100:I64V35 101:T64L29I05 102:S76N17L05 104:S94P05 106:A88T08S02 107:V61I38 108:A97T02 109:P94L05 112:M79K11E05V02 113:I35L26V20F17 116:G82S11R05 119:K91R08 124:D94E05 130:G50A32N11K05 132:D94E05 136:R97H02 139:R97H02 140:M82L17 148:N79D20 152:P97I02 154:M85V14 155:K94A02Q02 159:K79Q17E02

161:V79T20 162:N79D17S02 166:D58A41 169:Q82R17 170:R94C05 172:A94T02V02 173:S82A17 176:S94T05 177:A73T26 178:R85S14 182:F97S02 185:I70L20V08 193:L91V08 194:Q94L05 197:V94T05 199:S91N08 200:F82Y17 201:D50E50 203:N97H02 210:E94D02K02 214:A94T05 216:L94Y05 220:A88S08T02

221:L73F23H02 222:V73I26 223:E64V20A11S02 224:K88R11 226:N64H20Q08E05 227:Q79H20

228:Q58H20R08Y08E02 229:I73L17V05T02 230:L94P05 231:L76H14V08 232:H76Y23

233:T32P23M20L14F05S02 235:F85W11C02 236:L82I 14V02 238:Y76H17R02W02 239:L97R02 240:T88S11 241:P82S17 242:D94E02N02 243:G97R02 244:Q50R44W05 245:R97H02 247:R94H02K02 248:R97K02 251:R50H29D20 252:L85I 14 255:D85H08R05 258:D85A14 259:A85D14 260:V97I02 261:I88V11 262:Q97R02 263:E85R08K02Q02 266:R79Q14A02H02 267:T85A11Q02 269:P70N14R08A05 270:T61Q17S17A02 271:Q97H02 273:I61A17V17T02 274:D82E17 275:D82A14S02 276:F85W11Y02 277:L97F02 278:K94R05 279:N50A35S08D02R02 281:A82-11R05 282:K88Q11 283:S76G 17T05 285:T94V05 286:L82M 14T02 295:S88A11 297:D97N02 301:K88N08R02 302:E94G05 304:S97T02 307:D97E02 309:R97K02 318:E88G 11 327:L94I05 332Ύ97Η02 333:H70N29 335:A97S02 336:K50Q26R23 340:Y94F02H02 343:R76Q14K05C02 346:Q85E11A02 348:V73I14A11 349:Q64R29N02T02 350:E94D02K02 352:L97M02 353:K79R14Q05 354:D79G20 355:R91C08 356:E88D08K02 357:P85T14 358:I32V26E20K17T02 361:E97G02 363:D97E02 366:A88S11 367:Q91K02N02V02 371:L88T11 375:I97V02 386:P70T29 387:V52A47 388:I58V41 389:S94T05 391:C79R20 392:C94V02Y02 393:T97S02 394:Q85E 14 396:I91F02M02V02 397:V82K17 398197V02 400:D97G02 402:R97W02 403:V73I26 408:I50V29N20409:I64V20T11A02 411173126 412:I97V02

413:S85N14 414:I97V02 415:F61I23Y14 417:I61T35L02 419:H76Y23 422:T61A32E02N02 428:E97D02 431:D82N17 433:F82Y17 436:D70Y26N02 437:P50Q50 439:N97K02 440:I76S14P08 441:K79Q20

442:E79G08K05Q05 443:R97M02 445:P94S05 446194H05 448:F97L02 449:I85V14 462:A55N17T11V11M02 466:A97T02 469:K97R02 471:V97A02 472:L91V08 477194H02R02 478:R76H23 480:R97L02 481:I52V47 482:L88R08T02 484:D50T50 485:H61D11E08P08A02C02Y02 486:T73L17P08 487:E85R11K02 488:P94V05 489:-88Vll 490:R73C23G02 495:L97V02 496:I76V23 497:L91M08 499:A79T20 501:G85N14 506:R85Q11H02 507:V85L14 509:P97S02 511:G58S29N11 512:A41V29P17-08S02 513:N55G 17P17-08 514:S50P35-08Q05 515:Q73S14-11

(vi) N129

1:L90F09 2:G74R24S01 3:P77T07H05Q05L03 4:V98L01 5:A94T03V01 6:T46A38S05V05E01I01 8:P87A11S01 9:W53G35L11 11:L98F01 13:L59M35V03P01 15:V77A20I01 16:V44G40L11A03 17:G62A22L07V03S01T01 18:S88F09Y01 19:W90R09 20:L96A03 22:A88L09T01 23:R90Q07H01 24:V77I 12L09 25:L98P01 26:A88R09V01 27:W88F11 28:T87V05C03I01L01 29:Y88H09L01 30:A66T22R11 31:F92L05Y01 32:Y94R03A01

33:D68N14I09H05R01 34:N96K03 35:C81Y09R05A03 36:R94C01H01W01 37:R94Q03W01 39:Q68R31 42:P98A01 43:Q98E01 46:K88R11 47:R74Q25 48:N88H09S01 50:F90L09 51:W79L20 56:L85V09M05 57:I85V12M01 58:T66Q11A09G09K03 59:P94N05 62:E98Q01 64:L88M09F01 65:K72R16Q11

66:N70E24A01D01V01 67:L70V14S12M01 68:T94D05 69:Q98E01 70:L59I25M 14 71:S72V27 72:A96K03 74:Y83F11H05 75:S70P14R14 76:Q64H20P09D05 77:G85V07A05S01 78:F94C05 79:T40M24L14K09R09S01 80:I66V14W14M01T01 82:M66L31I01 85:I85F14 86:I75F09Y09L05 87:P98S01 88:F72I25V01 89:I81V12L05 90:V62R16T11I07F01 91:L98F01 92:C90F05V03 95:D98N01 96:T62I20Y11F03L01 97:I94V05 98:R88K11 99:S83P16 100:I72V27 101:T72L18I09 102:N87S09L03 104:S96P03 106:A98S01 107:I90T09 108:A87V11T01 109:P94L05 112:D53M 14E12K09A07N01 113:L83V16 114:F68S31 115:I61Y27T09V01 116:R77G 12S09 119:K96R03 124:E72D27 126:I68L31 127:L88I09V01 129:S88T07A01R01 130:G57A20N16K03D01

131:G85A07V07 132:D96E03 133:K98R01 135:S98G01 136:H55R44 137:H90R09 140:M88L11 148:N87D12 152:P85S12I01 154:I66M 16V16 155:K87T12 156:I98T01 159:K70E16Q12 161:A55V31T12 162:N51T37D11 163:I98S01 164:M98L01 165:L72H27 166:D72A25V01 167:K98R01 168:W98R01 169:Q88R11 170:H64R35 172:A98V01 173:S88A11 176:S96T03 177:S74A14T11 178:R90S09 180:D92N07 181:M98V01 182:F88S11 185:I96V03 194:Q96L03 195:K90R09 197:I75V18T05 200:F88Y11 203:H64N24R11 207:R74K25 208:P90S09 214:T74A25 216:L96Y03 220:A88S05T03G01 221:L98F01 222:V90I09 223:E70V12D09A07 224:K94R05 226:S62H 11T09N07Q05E03 227:Q75H12L11 228:H50R18Q16D11Y03 229:I79L20 230:L83F12P03

231:Q74L16H09 232:H77Y22 233:M83L07F03K01T01V01 235:F92W07 236:L74V16I09 238:Y98W01 239:L98R01 240:T81S18 241:Q50H24P14S11 242:D98E01 244:R96Q03 247:R83H14K01 248:R98K01 251:R87D12 252:L90I09 255:D79N09H05R03S01 258:D90A09 259:A90D09 260:V98I01 261:I92V07

262:Q87R12 263:E92R05Q01 266:R88Q07A01C01 267:T90A07Q01 269:P87N09A03 270:T79Q11S09 272:G90D09 273:I79A11V09 274:D88E11 275:D88A09S01 276:F90W07Y01 277:L92F07 279:D74A18S05R01 280:K98R01 281:A88-07R03 282:K92Q07 283:S85G 11T03 285:T96V03 286:L88M09T01 295:S92A07 297:D98N01 301:K92N05R01 302:A66E20P07G03V01 304:S96A01T01 305:D98N01 307:D98E01 308:I90V09 309:R98K01 318:A62E22G 14 323:T98M01 327:L96I03 330:V94I05 333:N94H05 335:A98S01 336:R88K11 339:E98Q01 343:R90H03K03C01 346:Q90E07A01 348:V85I09E05 349:Q90K05N01T01 350:E98D01 353:K88R07Q03 354:D88G 11 355:R98C01 356:D59E38H01 357:P87T07A05 358:K85E12I01 363:D92E07 366:A92S07 367:Q96K01N01 369:P98S01 371:L92T07 375146I27V25 378:S98A01 379:L98C01 380:R98G01 381:L98Y01 382:H98I01 384:P98T01 385:A74V25 386:P81T18 387:F75A12V11 388:I87V12 389:S96T03 391:R40H31C27 392:C98Y01 393:T85A12S01 394:Q90E09 396:I79T09V07L01M01 397:V88K11

400:D96E01G01 407:G96C01D01 408:I64N22V12 409:I88T09A01 411:V57L31M09I01 412:I98V01

413:N74S24D01 415:I61F16T12Y09 416:G92A07 417:V57T20I 14L07 419:H98Y01 422:T75A18S05 425:P98A01 426:D98N01 428:E98D01 431:D85N14 433:F70Y29 439:N96K03 440:S83I 11P05 441:K81Q18

442:E68G 14K12Q03 445:P96S03 446:L96H03 449:I88V11 453:A98G01 455:P98S01 459:I98M01

462:A70T14N11V03 464:A98P01 466:A98V01 469:K98R01 470:T50V48A01 472:L94V05 475:M53T35L11 477:L96H01R01 478:H72R27 480:R96L03 481:F74V25 482:L90R07T01 485:H79D07E05P05C01 486:T94R05 487:E90R07K01 488:P96V03 489:-92V07 493:P98L01 495:L98V01 496:I88T11 497:L61M38 501:G90N09 506:R88Q07H01W01 507:V92L07 509:P98S01 511:N74S24G01 512:A61T12V12P11-01 513:G83P11- 01N01S01 514:L72P22Q03-01 515:Q87S09-03

(vii) N151

1:L92F06P01 2:G80W12R05E01S01 3:P80Q07H05T04S03 4:V68L08A06G06T05M04S01 5:A83T10S03V02P01 6:A78V15P03S03 7:S98C01 8:P86L07A05S01 9:W93L06 10:L97H01Q01 11:L75I 19F05 12:L80G 19

13:L92P05V02 15:V54A29I 15T01 16:G86L06A02S02V02M01 17:A61V19T10L04G02F01S01 18:S80A07F06T06 19:W83C11R05 20:L96A02I01 22:A88L05G03V03 23:R62Q15Y11H07C03 24:V52I36L06F04A01

26:A58T25R05S04P03V03D01 27:W72Q11F06R06-02S01 28:T52I 19S09V06A05M03C02G01L01

29:Y92H06L01 30:A52T28R10S04K03G01V01 31:F73L09V09I03A01C01M01Y01

32:Y87F05H02R02A01C01N01 33:D57E30I05A03N02R01V01 34:N80I 10K08T01 35:C52S40A05F01N01 36:R75C08H08G03L02S02Q01 37:R98H01 39:R84Q15 40:C87G09R03 42:P98A01 43:Q96E03 45:P98L01 46:K75R16L02T02V02G01P01 48:N97S02 50:F57L34I08 51:L68W25F03V03 54:L78Q15V05I01 56:L64M35 57:I95G02M01V01 58:Q55H34P05K03R02 59:S83P10A03N03 60:S86T13 62:E90Q05D02G02

65:L79Q14K04R02 66:Y84E10D02H02A01 67:T59I26V11A01L01M01 68:Q86T08D03A02

69:S44G31D08Q08K03E02N02 70:L98P01 71:A53V43S03 72:C28R28S25A06G05D04K02N01 73:T98S01 74:F64Y34A01 75:G69R23S04K01P01 76:D86H05Q03R02T02K01 77:V62M25A06G04L01S01

78:C84F09G05L01 79:C85L08I02K01S01V01Y01 80:W94S02L01M01T01 82:V83M 10L03I02G01

85:W79F08C04I04L04 86:H61Q19Y06L03S03F02I02N02 87:A69P27V02S01 88:V56I41L02 89:V51I45L03 90:R85H10T03N01 91:I82L15V02 92:F90C07V02 93:H90L08Y01 95:T60S15D12A11 96:Y37C32F26I02L01T01 97:I94V05 98:K93R06 99:P95A02T02 100:V98I01 101:L94I04V01 102:F65L23S06N04 103:A98T01 104:P88S11 106:A75S11T10N02L01 107:I67V21L10 108:A77V18T04 109:P82L09I03S03H01M01 111:D98N01

112:K41M25V12T08S06R03E02F01 113:V69F16L13 116:S65R15G 14E02N01Q01 118:L98M01 119:K67E 18R13 124:D96E03 125:G98S01 128:L91M08 130:A83T06N04K02D01E01G01S01 131:G98S01 132:D94E05 135:S96G01N01R01 136:R83S13Q03 137:H96R03 139:R90H09 140:M92L07 148:N92D07

152:P93S03A01I01L01 154:M52V47 155:K98Q01 156:I98V01 158:N81T16K01S01

159:E46D35G06Q06K03A01N01 160:S98T01 161:V47T41A06M04 162:N83K09D06S01 163:I71V23T03L01 164:M98L01 165:H96L03 169:Q82K10R06H01 170:R58L33C05H01N01P01 171:L96V03 172:A69I 16V13 173:S89A06T03L01 174:E55Q20G10K09W03D01 175:G98S01 176:S88H03N03T02G01K01R01

177:A72T26N01 178:R80H08C05S05Y01 180:D94N05 183:E98D01 184:H95L03Y01 185:I97V02 186:S96N03 193:L98F01 194:Q97L02 197:V97T02 199:S98G01 200:F92Y06L01 201:D75E19N05 202:S98T01 203:N56H42Q01 206:E96D03 209:S98I01 210:E93K04A01G01 213:A89T06E03V01 214:A98T01 216:L97Y02 217:E93D03Q03 220:A94S03T02 222:V96I03 223:A64S18V09T06E01 224:K85R14 226:H91Q06E02

227:Q85H11R03 228:Q78R06E05K05S03Y02 229:I47L42F09 230:L58F30H05P03W03 231:L85H05V04- 02M02Q01 232:H72Y26Q01 233:I33M18V12L11P07T07F05K02R01W01 234:D98G01 235:F81L11W04S03 236:L81F10I05V03 238:Y58H40W01 239:L97F01R01 240:T93S06 241:P45H17C16R11S07T01 242:D98E01 244:Q67R12M 10H07K01T01 245:R98C01 247:R98K01 248:R77K19T03 251:R91D08 252:L84I06V06Q03 255:D86N08H03R02 258:D93A05N01 259:A94D05 260:V93A04I02 261:I95V04 262:Q87R12 263:E94R03Q02 266:R82C07H04Q04A01S01 267:T88A04S03I02N01Q01 269:P67S19N05K03A02L01T01

270:S39D25N21E07Q06 271:Q95H03E01 272:G97A01V01 273:V58I 13A09D06G06T06 274:D85E13G01 275:D92A05E01S01 276:F80V08W04A03S03Y01 278:K56Q37E05M01 279:A94S03R01V01 280:K98E01 281:A91-04R02T02 282:K87R07Q05 283:S50A29T13G06N01 285:T97V02 286:L93M05T01 294:L88M11 295:S80T11A05N03 296:K96E03 298:E87K12 299:D82H 11E03N03 301:K87E03N03R03T03

302:E50K25A12Q06G05R01 304:S98T01 306:E97K02 307:D97E02 308:I96V03 309:R98K01 313:D95N04 314:T98N01 315:F95V03I01 318:E58G33A08 320:H98N01 322:T98S01 323:T98A01 326:G98S01 327194105 330:V87I08A04 333:N63H36 336:K76R23 342:E97D01V01 343:R94K02C01H01Q01 346:Q89E05K03A01H01 348:V94I05 349:Q73R21E01L01N01T01 350:E95D02A01N01 351:L93V06 353:R52K43Q02E01S01

354:D71G27N01 356:E86R06D04G01K01Q01 357:P93T05S01 358:E48K42Q07D01 359:E93D06 360:I97M02 361:E98G01 363:D91E08 365:L98M01 366:A90S04T04V01 367:Q91H07N01 368:L96M03 371:L95T04 375:I93M06 379:L98M01 381:L97I01M01 382:H97Y02 384:P97S02 385:V90A09

386:T47P37S07L03I02G01M01 387:V52A36I07T02G01S01 388:I67V28A04 389:S97A01T01

391:C73H 16R06S03 392:C83V15Y01 393:T96S03 394:Q91E05R03 396:I89V08T02 397:V86K06M03E02I01R01 398:L96F03 400:D98G01 403:V90I09 408:V72I 19N07 409:I87T11V01 410:C97S02 411:L77H11R11

412:I84L09V06 413:S98N01 414:I66V33 415:F83L11Y05 416:G97A01E01 417:T90L06I03 422:A66S19T12V01 426:D87N12 427:P97L01S01 428:E98D01 430:Y98F01 431:D73N26 433:F92Y06S01 436:D95N04

437:P79A11S07L02 438:E83D11K05 439:N97H01S01 440:I47S26T10A06G03P03V03 441:K81Q16E02 442:E47G20D16K12Q02 444:S96P03 445:P94S05 446:L97H02 449:I93V05L01 461:Q98K01

462:T70A15N09S03I01 465:M96L03 466:A50T37S12 468:M93I06 469:K98R01 470:V98A01 471:V83A16 472:L96V03 473:A92G07 474:L96M03 477:L94Q03H01R01 478:R96H03 480:R98C01 481:V92I03L03F01 482:L95R03T01 483:P98L01 484:D95G02H01N01 485:D35H34E12A09K03P03R01S01

486:T71E11K11A03D01V01 487:E93R04K02 488:P97V02 489:-95V04 490:R91L06K01Q01 492:K94Q02S02L01 495:L98I01 496:I62V37 497:L98M01 499:A98T01 501:G94N05 504:W98R01 506:R86Q11G01K01 507:V87L12 509:P94L03A01Q01 510:L98V01 511:S86G06N06R01 512:-39A38T07P06E04S03G01 513:- 45G30D07P06R04Q03S02A01 514:-45P25A23Q02S02L01 515:-55Q20R06P05S05H04A03

(viii) N195

1:L78P07F04M04-01R01 2:G82R07S03-01T01 3:P62S18Q05A03T03-01L01 4:V73L20-01G01

5:A74L12V06T04S01 6:A84T06S03E02V02 7:S96F01 8:P78S07L07A03T02 9:W95L04 10:L54H33Q11 12:L95P04 13:L96Q01V01 14:L93F02M02V01 15:V37G29A17L07F05M01 16:G80A13L04V01

17:A86T04L03V03 18:S86T06F03-01 19:W89L06R03 20:L62I 19F11V03A01 21191V08 22:A90L03V03 23:R91Q03Y02H01K01 24:I48V44L03M02 26:A89R03T03S01 27:W85F04K03R03

28:T44I39S06A02F02V02C01 29:Y88H06C01F01 30:A47S25T14R05V04 31:F87M03Y03L02I01

32:Y81C12H03R01 33:D67E22I03S02 34:N88K05Y05 35:C81S08Y04A02V01 36:C49R22S14A05L04Q02 39:R96Q02 42:P91R03Q03 43:Q97E01 44:P84S09A05 46:K76R14S08 47:R85P08C02 48:N73S18H08 50:F90L09 51:W73L24 54:L90M06V02 55:G79S07A07D03 56:L48M35T07I06Q02 57:V33I27A20M16L01 58:Q51K38S03T03R01 59:S62N19G07P06T02L01 60:N84T10D04 62:E91D03Q03 63:G88D07S02 64:M62L37 65:R54Q39K06 66:L65M 15E07F07V02 67:V55I24M08L06A05 68:E50T35A08D02S02

69:E44D33H10Q06R03N01 70:L74M22 71:G81V09S07 72:H67K12Q07A05R02T02

73:Y41T25H 13N04C03Q03I02D01S01 74:F93Y05 75:R75H14P05Q02 76:D90H03Q03 77:V80I 11A04G01 78:H70Q14F07Y03C02 80:W57C28S06F02L02T01 82:L34M32F14I 11V06 84:P92A07 85:F55V32I05L05 86:Y60I 18F08H03C03L02D01 88Λ/48Ι47Α03 89:L91I03V03 90:R83H07K05T02I01 91:L96I03

92:V70I 14T04C02F02S02W02 93:H81D18 95:K44A16N14T14D08 96:F88Y05V03T02 97:V50I41A07

98:A88K04R03G02 99:P95S02 100:L68V29I02 102:Q79H10N03L03S03 104:P71S28 105:A92V07

106:A48T23L17-03E02V02 107:V70I26A03 108:A70I17V08T03 109:P96L01 111:D79E18 112:M88T04K03E01 113:T44F22V11I07L04S03Y03D02 114:F83L09S04 115:Y85L13 116:G55S27R08N06 117:F85L07P06

118:L92M05V01 119:K93R06 120:P90L09 124:D94E02T02 127:L81F18 128:L84I07V06M02 129:S96K02 130:A64S24N03T03D01G01K01 132:D84E08N04G02 133:K97N02 135:S85R09N03K01

136:H40R38S09W07L02Q01 137:H93Q04R01 139:R90H08 140:L92M07 148:D58E31K07N03 152:P85S10L03 154:V66M30L02 156:I87V06N03T03 158:N98S01 159:K77Q10E03T03D01N01R01 161:V44A39T15

162:N60D32G05 163:I97T01 166:A85D06V03G02 169:Q66K25R07 170:R82H08C07K01

172:A70T18S03V03C03 173:S37L35A21T05 174:E75K18G03Q02 176:S85N10T03 177:A71T25

178:R81H08C06S03 180:D80E18 183:E97A01 184:H84N15 185:I96V03 192:S92I06 194:Q98L01

197:V66L18I10A03T01 199:S80G 19 200:F85Y12L01 201:D96N02 203:N85H07K03D02

207:S44K29N15H06Y03 208:P96N01 210:E95K03D01 213:A85D07S07 214:A98T01 216:L95Q02Y01 217:E96D03 219:S96T02 220:A54S44T01 222:V55I42 223:V50T23M09A07I07L01 224:K97R02 225:R93K06 226:H37S11Q10Y10N07I07A05T05D02E01 227:Q48R18H15E14 228:Q79H09K04R03Y01

229:I48L35P07V04M02 230:F85L10I02P01 231:L87Q05H03M03 232:H44Y41Q07F04R01

233:M42V25L18A07S03F01 235:F96W03 236:L95I03 238:Y81F10N06 239:L88R05F02H02 240:T97S02 241:P54A34S10 242:D81N 16E02 244:R74Q16W08 247:R83C06H03Y03-01L01 248:R55K44 249:A96T02 251:D66N18R08E06 252:L80I14M03V02 255:N49D33K05S04E02H02R02 258:D92A03G02

259:A91D03N02T02 260:V88I 11 261:I96V03 262:Q61R37 263:E86K09R02 266:R81H09Q03S03C02

267:T79A09I05L02-01 269:S25I21A16N13T12V05Q02 270:S88Q04H03T03 271:Q93G05 272:G77S17N03D01 273:V60S29A05H02 274:D62H21Q08E04-01N01 275:D44E44A09 276:F84L08W03I02 277191V07

278:K85Q13 279:A67S18T10V01 280:K96R02 281:A66T22-03S03V02R01 282:K96Q03 283:S55A26T10G04L02 284:K97R02 285:T97V01 286:L92M06 291:V98I01 294:L95M04 295:A92S07 297:D96G03 299:D40H37N22 301:K95N03E01 302:E73G 18Q03R02K01 304:S97P01 305:D96N03 306:E96S02 307:D96S02 318:G53E34A11 323:T97A02 326:G74A25 327:L98I01 330:V48I40T07A03 336:R73K25 339:E95K03 340:Y91W04C02H01 342:E96D02 343:R92H05K01 346:Q95E03 348:V96I03 349:Q78R17W02 350:E93Q05 353:R73K19G05Q01 354:D74G16N07 355:R96L02 356:E81D17 357:P86L04T03S03 358:E44K32Q22 359:E97D01 363:D92E07 364:D98E01 366:A88T03V03S03 367:Q97R01 369:P97T01 371:L96T03 373:M97T02 375:I88L11 383:P92S07 385:V95A03G01 386:T63I 13S07A06V03P03L02 387:V47D18A08M07R07I03L03S03 388:I74L18V05M02 389:S66L13A05V05Q03H03 391:C57R30G04S03L02 393:T85I07A03S01 394:Q89E03K03R02 396:V62I37 397:V73L07A06G05K05T01 403:V97I01 406:K96R03 408:N85S07T06 409:I63V09D08T07A05M03

411:V60I16T10L06M03A01 412:I90V09 414:I98V01 415:F92Y03T02 417:I61V31T07 422:S91A07 423:V91I08 425:P94L02 426:D96E02 428:E96K02 430:Y93F06 431:D62N37 433:F93Y04S01 436:D95N03 437:P98S01 438:E96D03 439:N74T14A05S03 440:P78L09S06R02I01 441:Q92L02-01K01 442:K92G03E02Q01 445:P96S02 446:L98H01 447:A96S03 449:I96V03 453:A86V13 455:P91S05N02 462:T90N04A03 464:A97G02

466:A35N29T24S10 468:M95I03 471:V50A48 472:L93V06 481:V77I 18L03F01 482:L95R03 483:P93C05 484:D95G02A01 485:D41E25H07L07Q03-03N03P02G01 486:K37A25E23T11 487:E95R03 488:P96A02V01 489:-96V03 492:K82Q14L02 493:P90S07L02 495:L88I05V05 496:I95V03 501:G85D07N06 506:R90Q08 507:V87M08L03 509:P97L01 510:L97Q02 511:S86N08R01T01 512:A42T30S09-04P04G01K01R01

513:G66D10-07N07P04V01 514:P37A28-14T07Q07L03S01 515:Q82S04-03P03K01R01

(ix) N261

3:L57V15T10I06A04M01 4:Y90V03C02G01W01 5:A95T02 6:V76L09I05G04S02 7:S96T02

8:A62G 14T07M06V04S01 9:L91I06F01 10:L95V02F01 12:S71F12L08A03G02T02 13:L95V02G01 15:F94A04 16:F76L09I06S05V01 17:L77F19 18:F96C03 19:R93H06 20:L90F04Q02A01 22:L84M07V04I02 23:Q71R20K04 24:F72L14V10 25:L85F13 26:R75Q13K07G03 27:L76I09F08V04R02 28:C93S02V01 29:W71R11H09Q04L03 30:R42H17S12A07D07G05K04 31:F96C02 32:Y70H 17R10 33:I63V16T12R04 34:T89I04N04L01 35:C98A01 36:R85C06Q05H01 37:R97Q02 39:R82S16 42:P95R04 43:Q92E07 46:R86G 12 47:R94K04 48:N80S09H08 51:L94M05 54:L88V07M04 55:G92S06 56:M98L01 57Ύ95Ι03 58:L95Q02K01 59:P97N02 60:N95T04 62:T29S17A15K14M09R07E04 65:Q85R14 66:D85N08E03A01 67:E95V04 68:K77T09M04D02N02S02 69:K95Q03 70:V93L05 71:L95V04 72:D85N06E03A02K01 73:N52T18S12D07A04K01 74:M85L04N04Y02F01 75:H90R09 76:H90D05Y02 77:V76I 11A10 78:I64V15L14C02F01 80:V86A08W04 82:M40I37V09A05L05 85:V71F17I 10 86:L97Y01 87:P98S01 88:L94I04 89:L73V25 90:V95R04 92:V91M04F02 100:L57V37I04 101:L57V38M03 102:G82S13A01L01 107:I85V14 109:P98L01 112:D71E22K06 113:L84F15 116:G85S14 119:K92T04R03 124:D98E01 130:K89R07N03 132:D78E12N08 140:L92M07 154:M96V03 157:F95Y04 160:C95S04 161:T87A10S01 162:D74N23 163:I86T09V04 166:A85G06D02N01S01 169:R83Q10H04W01 170:R94C03G01 171:L92Q05 172:A78G08V04S04T04 173:E71A10Q09N04G01K01 174:G90E04N03K02 175:S75P09A05G04K04 176:V74E09T05M04D02S02 177:V66A19I07T06 179185F14 183:E97K01 185:V78I21 188:M90L09 192:S92T04C02 194:Q98L01 197:V98T01 200Ύ93Η04 201:N93D04S01 203:N80D19 207:K90R08 208:M88N04P04Q02 210:D95E04 213:S90T04A04 214:A94S05 216:I95L02Y01 220:A93S04 222:V76A19S04 224:R86K09Q04 226:Q98E01 227Ύ95Η04 228:R94H01S01Y01 229:L91I04V03 230:H95L03P01 232:H52Y47 233:L65I31F02 234:D94N04 235:F90W03C02L02 236:I96V02 238Ύ97Η01 239:R57L41 240:T82S17

241:A90E04S04V01 242:D98E01 247:R92K04Q01 248:Q77R11E05K04 252:T73I 15M09

255:H44R38S06K05G02 258:T94A04 259:E93D06 261:I96V03 263:E90K02R02Q01 266:R68Q20L05W02 267:A94V02 269:R52H23N11C07S03 270:Q86K07E02R01 271:Q90L09 273:A89S04M02P01 274:E96K01 275:A91M04 277:L97F02 278:K97Q01 279:A65S22G 10 280:K96R03 284:K98R01 285:T95A02V01

286:L95M03 289:I95M04 295:A98S01 296:R57K38Q04 299:D90E09 301:K95N04 302:E90Q04G04

303:L97M02 304:S89T10 305:D95N04 324:S94A05 327197102 330:V85A08M04 331:L97F02 332:F95Y04 334:L95M04 336:K90R09 337Ύ88Η 11 342:E94D05 343:K96R03 346:E91K06 348:I97V02 349:Q96R01 350:E87D10 351:V83I 11L04 352:M86L13 353:K94R03Q02 354:G97N02 356:E96D03 357:L84T07V04M01P01 358:E85D12K01 360:L87I 11 361:E85D14 363:D95E04 366:T88A06S03P01 367:Q90L05R02 368:L94M05 371:T83I 14L01 373:M94L05 381:Q85L11K02 382:F84Y10H04 387:L94A04 388:V75I24 389:S97T02

391:R90Q08C01 394:E96Q03 396:I88V11 397:K95R02A01 398:L95M04 403:I80V19 408:I92N04V02 411:L95M04 412:V86L07I05 413:S95N04 414:I98V01 419:H71Y28 422:T72L13A05S04 427:S87P05A04Y02 428:K94E04 430:Y92F07 431:N97D02 438:D75E20L03 439:N84K06T06I01 440:P88S08T02 441:Q95E02 442:Q95E02G02 445:P97S01 446:L98H01 448:Y73F26 449:V85M07I05L01 462:S94N04 465:M95L04 466:A93S06 469:R89K10 471:A59V40 472:V96L03 481:L95V04 482:S90T04R02L01 483:V95P04

485:R94P03E01 487:R87K06H04E01 488:K94P03V01 489:V98-01 499:T91A07 501:N83S09D04G01 503:I93L06 506:N75K18Q03R02 507:V97L02 511:P89S07N01 512:P90G04A02R01 513:R83L05Q04P04 514: A80G 06T04P03Q02V01 515 :-89A04P03S03

(x) N337

1:V48L27F15A03M03T03 2:L39F27S27G03T03 3:S66P24L06V03 4:W66L27R03S03

5:T45A21S18C03L03N03Q03V03 6:G60S30L06T03 7:L66I 15G 12S03V03

8:S63C06G06I06A03F03L03R03W03Y03 9:L33Q18F15S15V09P06A03 10:L60V33A06 11:L87F03G03M03W03 12:Q48L15A09Y09G06V06F03S03 13:V51L36I09G03 14:V27L24M 15S12F09-06A03T03

15:G48A30S09C03I03Q03R03 16:T33L27A21-06G03I03N03S03 17:G48A15V15T12-06L03 18:L69F12- 06C03G03P03V03 19:L36V27-06A06G06I06C03F03K03R03 20:A75L12T09V03 21:V54L39A03I03

22:V60L33A03T03 23:A42G21R15S12L06T03 24:V42L36F15A03I03 25:W69L12R12A03I03

26:T75V09R06I03M03S03 27:A42V27L12-06F06S03T03 28:R51K27C09-06L06 29:L84-06W06I03 30:R75S09- 06C03H03V03 31:H81Y09-06V03 32:A87-06S03V03 33:W69R15Q09-06 34:Y66F15N15R03

35:T75R12A09N03 36:H69R24N03Q03 37:R87K09A03 38:L87M09V03 39:S69R21A03G03K03 40:C96R03 42:S57N30A12 43:K78Q15L03R03 45:P60Q15H09-06R06T03 46:T54A21M09-06K03L03R03 47:R57H21Q09- 06D03N03 48:S69N27C03 50:L90F06I03 51:L60I21M 18 54:L93M06 56:Q60L15E12K09I03 58:Q66K15R15G03 59:S90N06H03 60:T87S09N03 65:Q66L27K06 66:Q57A27R12E03 68:D96E03 69:E69D21Q06R03 70:L96M03 72:Q63R24K06C03H03 73:T78M15K06 74:Y90F09 75:K63T15R12E03G03S03 76:H90Y09 77:S90C09 79:S69C27A03 81:F93W06 82:L63F18I 18 87:H69S24N06 88:L72M 18I06F03 89:V93I03L03 91:L63V33I03 97:V69I30 98:K96R03 99:P96S03 100:L93V06 102:M66L24T06F03 104:P48S48A03 105:A93G03S03 106:S69N27A03 107:I96L03 108:T93P03S03 109:V60M 18L12I03W03Y03 110:K96T03 111:D96V03

112:E93D03R03 113:L81F15I03 114:I48F33V15S03 115:Y96L03 116:G84H09D03S03 117:H66F27L03N03 118:L93M06 119:R84Q09K03L03 120:P96I03 121:W96C03 122:L96R03 123:G96A03 124:Q57N18R12E09H03 125:S78G 12-06C03 126:L87V09I03 128:L51I48 129:S90C03I03Q03 130:N93S06 131:G96K03 132:E93D03Q03 133:E66V12A06K06D03Q03T03 135:S90A03F03L03 137:K51R30H18 151:K96R03 152:N75I 12S09K03 154:V66I33 155:A39K21V21T06E03H03L03N03 156:T39I30K21V09 159:S42T24Q15H12A03N03 161:T78S12A09 162:N81D09K09 163:T66I30V03 164:M93L06 165:H96L03 166:D45N27A24S03 167:K96E03 169:R60H24C09Q03S03 170:R90H06Q03 171:L96V03 172:V78L18A03 173:A90S06V03 174:E78G 15K03N03 176:T60E21K09P03Q03S03 177:T81S12H03N03 178:N60S21C06H06A03R03 179:L48I27V18F03Q03 180:E69D30 181:M84L06V06A03 183:D57E30S09Q03 184:H84Q12D03 185:V69I24F03L03 186:T63S33I03 187:L93M03S03 188:M93L06 195:K96R03 197:A69T30 200:Y96C03 201:D39N39Q21 202:S96T03

203:N81D12H03Q03 204:C96S03 206:E69R18Q12 207:S78K18N03 208:S66T18P09N03V03 209:S93D03R03 210:E81Q18 212:V60I30A09 213:S75A18L03T03 215:I96V03 216:V51M 15F12Y12L06I03 217:E90D03K03Q03 219:S96G03 220:D69T21I03N03R03 222:I54V30L15 223:I81V15Q03 224:D48E33K12N03Q03 226:R72E15Q12 227:F27Q27H 18G09K09R03T03Y03 228:R42K30Y15N09H03 229:I81L18 230:L81P15W03 231:H96Y03 232:H84Q15 233:W93F06 235:W87C06F06 236:I69L21F03V03W03 239:R54K45 240:T75S24

241:Q42E24P21R06A03S03 242:Q72E27 244:K66R27E03Q03 245:R93E03Q03 247:K87Q06R06

248:Q57K24R18 250:L69C30 251:S48D24N18G06A03 252:V57I30T09L03 254:H96Q03

255:R75G09K09Q03S03 258:R78A18M03 259:D66E21T09S03 260:V81I 18 261:V96I03 262:Q90E09

263:K51E21M15R12 264:R96H03 265:R93H03L03 266:A78T18E03 267:L66Q27E03K03 268:I57L42

269:N33S24D21L09A03G03H03R03 270:Q87H09E03 271:Q84K09L03R03 272:R54G36K03S03T03

273:T51P18A09E06V06I03K03S03 274:E60Q15L09-06D03G03M03 275:S42T39A12-06 276:D24H21- 12E12S09L06Q06Y06N03 277:L36M 18T12-09I09F06A03E03P03 278:T48G 15-09A09K09E06N03

279:T42R21P12E09-06A06L03 280:A45E18-12T12G03K03P03Y03 281:-78R12K09 282:P33K24A18Q15R06E03 283:Q63K21G06R06H03 284:K69R27G03 285:K60V27R09N03 286:K66T21A06R03V03 288:F96L03

289:V69I30 291:I54L33V12 292:I57L42 295:S84T12A03 298:E93A03D03 299:D84E09H03K03 300:G96E03 301:Q69K12N09E03H03R03 304:T96S03 305:D96N03 306:E96K03 307:E96D03 308:I78M09V09L03 309:Q69K30 311:E90D03H03Q03 313:N69D30 314:T96M03 318:A84E12G03 323:T96A03 326:A72G27 327:I96L03 328:C63S36 330:T60V27S09I03 331:L96F03 335:A87S12 336:R75Q12H03L03M03S03

337:H87N06Q03Y03 338:P36D21E18Q18N03S03 339:H66D21E12 340Ύ93Η06 342:E84D12H03

343:K69R24N03Q03 346:Q66A27D03K03 349:M66N27R03T03 350:D66E27A03S03 351:L96V03

352:M66L30I03 353:Q75E21A03 354:G87D12 356:D84E09Q03S03 357:G54T30V09E03R03

358:H51E24Q15D09 359:E75D09A06Q06T03 360:I93L03V03 361:E75K06Q06D03G03L03N03

363:E90D06N03 366:S87T06A03N03 367:N84S12Q03 368:L96M03 369:P93S03T03 371:T96I03 376:K72R27 382:H96Y03 383:S81P15A03 386:Q66S18L06T06A03 388:V93I03L03 389:T96S03 391:K45R36S09A03T03Y03 392:Y96F03 393:T72S18I06L03 394:Q66E21K06R03V03 395:D96N03 396:M63V24I09K03

397:T36A21E15K12V09D03N03 398:L72V21M03T03 400:G96E03 401:D45G30N12E09H03

402:R63L27C06H03 403:T66V27A03S03 404:V69I30 406:Q51K27A12E06H03 408:A33V24S21T09N06C03I03 409:I96L03 410:C96S03 412:V87I06A03L03 414:I72L27 417:T93I03V03 419:H96R03 422:T36E30A27K03Q03 423:V93I06 425:T63P30Q03S03 426:N66D33 428:H69D24E03L03 429:E60V30D09 430:F60Y39

431:D66N30R03 433:L57M21Q12Y06T03 436:D81E18 437:P96A03 438:T48E27A09S09H03K03

439:N93H03R03 440:T42S30K12Q09A03I03 441:K48E24Q21A03D03 442:G48S45D06 443:R72L12Q09H06 444:S84T09A03P03 445:S93P06 446:H93Y06 447:A75G21S03 449:I87V12 453:S81A18 462:K81N18 465:M72L27 466:A96V03 467:E96Q03 468:L72M27 469:R96K03 471:V96A03 472:V96L03 477:L69R27A03 478:R93K06 480:R90H03K03Q03 481:L90V06I03 482:T87L06S06 483:P90L06S03 484:G93D03K03

485:P54G 18-06S06A03N03R03T03V03 486:S60P18V09C03E03F03T03 487:G54E27S09K06A03

488:K30V27G 18R15E03P03T03 489:V78-21 492:L93K06493:P93Y06 494:Q90D03E03T03 495:L96V03 496:V87I12 497:L96M03 498:R93G03K03 503:L96M03 504:W90I03Q03R03 505:L96M03 506:Q90H03R03T03 507:L72V21F03I03 508:E96Q03 509:P69D15T12E03 510:L87V09I03 511:N66D15T12E03K03

512:P27Q27E24T12K03M03S03 513:P42S21E15-12H03Q03T03 514:Q24-21S18E12N12T09C03 515:- 39L24F15S12D06E03

Table 4. Variable residues Xi - X_n, and amino acid variation at each residue, of engineered ancestral CYP4ABXZ sequences corresponding to nodes (i) - (iv). For each of the ancestral sequences corresponding to nodes (i) - (iv), variable residues Xi - X_nare given in sequential order. For example, for (i) N2, 411 variable residues are given: Xi - ¾_n. For each variable residue, the format of the data is as follows: [amino acid position]: [first amino acid variant] [percent frequency of first amino acid variant] ... [last amino acid variant] [percent frequency of last amino acid variant]. Position is given relative to the corresponding AO CYP4ABXZ sequence, as described herein Frequency is relative to all sequences used to construct the AO CYP4ABXZ sequence. Note that '-' represents a 'gap' or amino acid deletion. For example, X₈ of (i) is given as 8:A52V22L20F01, which sets forth that:

the amino acid position of the variant relative CYP4ABXZ N2 A0 is '8';

the first amino acid variant is a Ά';

the frequency of the first amino acid variant relative to all sequences used to construct CYP4ABXZ N2 A0 is 52%;

the second amino acid variant is 'V;

the frequency of the second amino acid variant is 22%;

the third amino acid variant is 'L' ;

the frequency of the third amino is 20%;

the last amino acid variant is 'F' ;

the frequency of the last amino acid variant is 1%

54:E66H12Q08K07N02D01 55:K48Q19E17T06N04S01 56:Y57F41 57:P94L01S01Q01

58:Y39C25S23R04H02K01 59:A97C01G01 60:F48C26H19S02V01 61:P89A02Q02S01L01T01V01 62:R41L25C10H06M06Q03V01I01A01F01 64:F38L35V14I06M03Y01 65:G66W28S03

66:P41G37Q12S04R01N01 67:F50S19V11T08G04N01I01L01

68:L24K23Q16I07S06V05R04M04E02T01N01 69:A38V18G17P15C04L02M01

70:F47S13R11H07L04T04Y02I01V01A01Q01 71:L60F20V15I03 72:N25V17L12Y12Q10I10F04M04S01T01 73:I67V21L09 74:Y68H20T05N02S01 75:D60H24E13 77:D78E20 79:A59M29V07I02 80:K98Q01

81:V30A24T24S09I04M04L02 82:I47V29F15L07 83:L74Y17F07 84:G49S35A07N04T01

85:R86Q06S04T01K01 86:S33T33G26R02K01A01 87:D92E07 88:P90R05H01S01 90:S37A35D12P07T03 91:H20N15Q13P11S09D08K05A03T02R01L01M01W01 92:G22D20V15Y12I09L05F05A02S02R01T01 93:S25V19P16L12T09A07I04F01G01 94:Y89H04N02Q01C01S01 95:K38R36D14N02Q02G02S02

96:F80L10H04Y01I01 97:L64F16M07I07V02 98:A24I17L17V16T10S05E04 99:P76Q15S06

100:W82C12L02S01 101 :I86L09V02T01 103:K38Y27Q10N09R05E04T02 106:L91V07

107:L32V28I17N11S05T02A01 108:L92S06 109:N33D30E16H07S03K03Q02

111:P43Q31T09S05K03A02E02I01 112:K66T23P04R03 114:F86H04Y03S02Q01L01 115:Q90R06E01K01 116:H98R01 118:R56K35H03C02Q01 119:L62M35I01 120:L96V01I01 121:T96K01 123:A53G45

124:F98L01 125:H93N04S01Q01 126:Y76F10C02L02N01H01I01S01V01 127:D80N14S02E02

128:I54V42T02 131:P68S18T06A02I01 132:Y94F02H01C01 133:V91I04T01A01

134:A32G23E14K09T07R04S03D01N01 135:L48V31I11M03T02 136:M77F16I03V02

137:A66S22V05T03N01 138:D60E13H13N06Q03S01K01 139:S98T01 140:V65T26A06I01

141:R30K26N23Q08H07C01 142:V57T19A09I08L01M01 145:D91G04N01A01 146:K96R01 147:W98L01 148:E94D02 149:K50E24Q15S03R02 150:L43K26I15Y05R02M02F01

151:I26A22C12V09N09L08S04T02D01W01 152:S24T23G19R14N03A03K03I02D01Q01

153:Q39E26T16K04D03S03A01V01 154:D51N13R12E07G07H02K02Q01

155:K38S31T15E05P02A01H01R01N01 156:S48P18T13H09V02C01A01I01L01 157:V41L35F20I02 158:E82D17 159:I48L27V23 160:F87Y06L01S01 161:E36Q35C12G06H03S01K01N01 162:H61D33P02Y02 163:V69I29 164:S68G17N11D01 165:L81H14M01F01S01 167:T73A24S02 169:D97N01E01

170:T42S40I14V01 171:I68L28V02 172:M94L05 173:K97Q01 175:A79T16I03 177:S78G18T02

178:H26Y26K16Q13C07F02R02W01 179:Q32E18N17G14H07K03D02T01A01S01

180:G31T25S25D12N02A01 181:N50S42T01C01D01K01 182:C48V19G16I08H02A01S01 183:Q84L14 184:T41I14L13G09V06S02A02M02N01C01F01 185:D41N18Q13H11E09S02Y01 186:S44R31G11- 07E02K01 187:N37T15R15D07S07G05K04E01Q01 188:S49D17H09Y06T05-03L02N02

189:D28Q24N21S10H05R03K02E01T01 190:S49Y14P12A05T04L03N03D01F01K01

192:I59Y16V13L05T03 193:Q37K35L11R10S01E01 194:A95T03G01 195:V53I31T10M04

196:Y26S20F15G09R08E06H02T01A01C01L01 197:D68E26N04 198:L90A03G02M01V01

199:S36N24T21G05C05K03A01 200:N28Y22L16K15H05D02E02R01S01F01 201:L77I16M04

202:V33I22M15F11T07L07A01S01 203:F43Q17S16H07N06Y03V01I01

204 : S28Q25 Yl 1N09L05H05F03E03D02 AO 1K01 205 :R98H01 206 :L30I28 V27M06F02 AO 1T01

207 :R49Y15Q 11E09D04H02K01N01F01 VO 1 208 :N45 S29T 12I04F02 V02M01

209:F60A13V13I04L02Y02P01 210:F33L19Q16P12S12W04 211:Y58H33F02L02D01 212:H60Q29-06K01 213:N58K13H12S11Y01 214:D95N03 215:I29F20T18L17V12 216:I78F14L04V01 217:Y75F24

218:W24K17R13S13N09D08Y04G04H02 219:L74F20M02 220:T50S49 221:P61S22R09H02T01

222:H28E18K15Q13N09A06D02L01S01M01 223:G97K01 224:R64H17Y07F05Q03

225:R47W16L08E08Q07D02K02C01I01H01N01 226:F59N08T08L07A05S04Y04

227:Q27H21R21L17N04K03S01Y01 228:R40K22E15D11Q04H02S01N01 229:A77L12I03V02M01F01 230:C76S10N03Y02V01G01A01I01R01 231:Q56K32R08E01N01 232:L46V30I16A02R01

233:A78L16I01T01 234:H96Q01Y01 235:Q37D22E13T10S04N02L02A01H01R01 236:H80Y17C01 237:T98A01 238:D78E19 239:K39Q32R11E06A03G02H02N01T01 240:V85I13 241:I95V03

242:K40Q31R24H02 243:E40L19D16Q09K08M02S01N01 245:K94R04

246:A43E17K16M11T02D02N01S01Q01I01 247:Q23S22A22L16H08F01V01 249:Q50K32S12R01E01 250:D44K12N11E10S09A04Q02G01 251:E85G06K03Q01D01 252:K37G29R12E04M04N02V02T02L01 253:E78K16V01N01 254:L55Q29F04R03H03M01W01 255:E58D28G05K04A01 256:K73N13R04T03D01 257:I54V23T18L01 258:Q60R19K15S01 259:K56R13N12S05Q04A03-01H01 260:K65R29-02Q02

261:R78K19 262:H62Y19R10N04C01S01 263:L80Q16R02 265:F98L01 268:I96V02 269:L84V11I03 271:F27C27S17G17L08 272:A83T09S04V02 273:K47R33Q17 274:D48M29A14S02T02 275:E87A10 276 :N77D09S05H02 277 : G81E05Q05D02R01K01 278 : S26V14D 14113N07 A06Q05K04E02T01R01 279:S41G30K14I05A02D01N01R01 280:L79F19 281:S96P01T01 282:D94N02E01

283:E37K23A22T12Q01M01 284:D96E03 285:L90I05V03 286:R85Q06W03H01 287:A84S15

290:D80N15S02K01 293:M94I02L02V01 294:F83L12V01W01 295:E71A26G01 297:H97Q01

299:T94A03S02 300:T88S04V03M02L01 301:A78T17S03 302:S82A08G07 303:G84S11A03 304:I88L08V02 305:S96C01A01 306:W95F04 307:I39L38F16V02T01 308:L75F24 309:Y98H01 310:C58A33H03S01 311:L68M31 312:A87S12 313:L46T22S09C05M03K03Q03A03I01 314:H50Y27N20 316:E86K11D01 317:H89Y10 319:Q59E17H11K04A02D02R01 320:R81K09Q03I02L02 323:E90D03K03T01

325:I70V25A02L01 326:Q49R31H05K04M03C02L01 327:S32G29E29D02A01Q01 328:I56L32V07A02T01 330:G90D03Q02E01 331:D86G07N02E01S01 332:G51R34K06Q05E01 333:D42A23S20T06E03

334:S64T31A01P01 335:I71F12V08M03L03 336:T47Q24E18S02D02I01H01 338:D56E35N06

339:D47H39Q12 341:G49D36S07N03A02 342:K48Q33E16 343:M90I07L01 344:P43T38S15 346:T75L16S05 348:M98L01 353:S51A36T05C03M02 354:L74F21M04 356:L95I02M01 357:Y69F14I10A04 358:P98S01 359:P95A02T01 360:V90I05A02 361:P94F01V01 362:S36G31Q17A05V03F01T01N01 363:V56I41 364:S56G17Y15A04V02F01 366:E46Q32Y07K05D04L01C01 367:L95I02 368:S84N06T05

369:K82T11S02E01Q01 370:P94S04 371:V49I38L09M02 372:T87N06S04 373:F97L02

374:P59V15S11F07H02A01I01 377:R93H03C02 378:S82T14 379:L96V02 381:A57K26E14T01 382:G98D01 383:I33S26C14M12F04T03V02L01 384:L26T22I15Q12M05N04S03H03V02P01K01 385:V74I17A02L02T02 386:S37V18G16T08A07L06F02M01I01 387:L77I09V08M01T01 388:S61N19H17 389:I83F11V03M01 390:Y61W19F18 391:A50G41L04T01 392:L74I23T01V01 394:H53R45 396:P65S14R14A03G01

397:A29K23D14T13S07N03R03E02 398:V86I09F02 400:P47E34K12N01S01 401:N55D40S02

403:E69K16Q05L04N02H01 404:V90I06E01M01 405:F85Y14 406:D96N03 408:L59S25F07M03Q02T01 411:S57A31L05T05 412:P78Q08K06L01S01T01 413:E67G18D11 414:N80-17K01 415:S39- 18V16L15A03T02I01 416:S47A25D15T05N01E01V01 417:Q29G16A15K12S08T07R04P01D01N01 418:R88Q10 419:H94S05 420:S61P37 421:H71F15Y11C01 422:A86S13 423:F95Y04 424:L75M11V07I05 427:S92A07 428:A65G31S02 430:P44S40A09M02 432:N97D02 436:Q67K31 437:Q83N07H06T01 440:M97I02 441:N74I09V04L04S02M01A01T01 442E96Q02 443:M50L42I04C01 446:A73V21I01T01 447:V34L25T22I13 449:L95M03 450:T63I19C16 452:L90K05N01Q01 453:R88H07K02 454:F93Y06 455:E78K09Q05R03 456:L66F16V14I01M01 457:S25L23A18T11C08I05R01F01Y01V01

458:P77L11E03V03Q01A01 459:D94E02N02 460:P88L06H01S01T01 461:T41S37A07L04D02F01E01N01 462:R61K24Q05N02L02T02H01 463:P50I16V16L09K04T02 464:P90L08

465:I46V16T10K07A05L04C01Q01F01S01 466:P39K21L16F12M05I03 467:I45M15S12L09V07T06Q01 468:P65A11N05S04L03Q02T02R02H01 469:Q48R34H08K04V01 470:L43I42V08M02F01T01

471:V72I22L01F01T01 472:L97I01 473:K48R47M02 474:S85P13A01 475:K69S13L05E02Q02R02N01T01 476:N89D03H03T01S01K01 478:I88V05M02L01F01 479:H88Y11 480:L89I05V04

481:H56R13K07Y07Q03C03F03N01S01L01 482:L91I05 483:K71R25 484:K70P16R06S03

485:L67I22V08A01 486:P21H18G11Q08R08S08L04C03E03D02K02T01-01F01N01

(ii) N4

1:L65V26-02F02I01 2:I35V34T15A05L04-02 3:L34F27C11A09I05V05-02Y02 4:V56G27L05I03A02S01 5:L56F25V12A02I01 6:L83Y07I03F02 7:K94Q02 8:L41V33A20F03 9:I31A21T17L16V08S02F01

10:Q50R20S06H05V03K03C02F02G01L01 11:L69F27I02 12:Y46L41F05C02T01

13:L39Q15W10R10H09A07I03V02 14:R52E23K14H03T02Q01 15:R93K05 16:Q42K40R12H03

17:K55E11M08R08A04S02W02T01F01 18:L88V04I02A01Q01 19:L32A30I28V02M02F01K01 20:K51R45 21:A86S05I02N01T01 22:L57M30F07V02 23:E46D33Q05A05S03K02 24:S38A35N07D06Q05R01K01 26:P97S02 27:G95C02 28:P90H08 30:T46K28A09S05R03G02I02P01 31:H98N01 32:W97V01 33:L97F01 34:F53Y41L03 36:H93N06 37:A34N30V25I06S01 38:H45L35Q06K03R02N02D01 39:E62L26Q07M02 40:I58F20L12V05M02 41:Q39T20K16L08R07H02N01S01 42:Q47T15K14S05A04R03E02L01N01 43:T28E22G22D20L01 44:G33K24E16T12N06Q03D02 45:S29D16I13V13E12M04G03F03A01

46 :L94F03M01 47 :D51N23E05Q04H04S02F01 AO 1101 YO 1 48 :K61Q26R05L02T02N01

49:V42I21M14L07F05A04T02G01 50:V63L13E09M04Q03A02I01 51:S66K15I05L03A02T02E01V01 53:A53G31T06S04V03 54:E48H26Q16N04D02K01 55:Q39E28K21T05S02 56:Y65F33 57:P90L03S02Q02 58:Y80S05H04C02Q01F01 59:A97C02 60:F53H41C02S02 61:P91Q04T02 62:L46R32M12V03H02I02 64:F64L25M04Y02V02 65:G95W02S01 66:P47Q25G10S08R03N02 67:F62V23S04G02I02L02D01 68:L49I15S12V11M06K02F01 69:G35P30A18C08V04S01 70:F55S24T05I02R02V02A02Y02 71:L94V03I02 72:N50V30I11Q02F02 73:I88V07L03 74:H39Y39T11N05S03 75:H51E28D18N01 77:D62E35A01

79:A84V11M02 81:A48S20T20V09 82:V47I44L07 83:L48Y36F14 84:S43G37A15T03 85:R73Q12S08T03 86:G53T33S06A02R01 87:D84E14 88:P82R12H02 90:A41D23S19P12G01T01

91:N23P21D14S13A07H04K03M03L02W02 92:D34V28I15L09F03A02G02T01

93:V33P23S17A12T06L02F01G01I01 95:K44D30R12N04G03S02 96:F84H08L04Y01 97:L55F31I11 98:L34V30I20E07A03T01 99:P60Q30S06 101:I96T01 103:K50N16Q15E06R05Y02D01 107:V56I36L05T01 108:L85S12T01 109:D29E23H12N11S06K06Q05A01T01 110:G98D01 111:P51T20Q14S06A04 112:K94T03 114:F82H08Y05L01Q01 115:Q84R12K02 118:K73R26 119:L89M10 123:G62A37 126:Y94N03F01 127:D93E03N01S01 128:V87I12 131:P71S25H01 133:V97I01 134:A57K14T12G06S04N01

135:L65V28I03M01 136:M57F33I05V02 137:A48S43T05V02 138:D65E25N04S03 139:S97T02

140:T53V33A12 141:K50R17H13N13Q02T01 142:V59A18I09T09D01 146:K97N01 148:E91D05G01K01 149:K58E20Q07S07R02V01 150:K55L23Y11R05-01 151:A41I25N19S05T03L02V02

152:T42R28N06K06S03A03G03Q02C01 153:E53Q14K07D07T07S03V02N01

154:D25R25N16G13E08K04Q02T01 155:K79E12S04R02 156:S81P09T05C03 157:V52F41L04 158:E68D30 159:L55I39V04 160:F97Y01 161:Q35E25C25S03H03N02K01G01 162:D63H35 163:V95I03 164:S64G35 165:L66H29F02R01 167:T64A35 169:D96N02 170:S70T28 171:I63L36 172:M94L05 175:A64T31I03 177:S65G34 178:Y37K30C15F05H05R03 179:N35G29H14Q07D03T02A02S01K01

180:S46D24T17N04A03G02E01 181:N58S30T03K02D01G01 182:C61G33I02S01 183:Q69L30

184:T61G20S05V03N02C02R01 185:Q27H24D18E16N07Y02K01R01 186:S62-15R13G04N01T01 187:R30N29D12G10S05K05E02Q02 188:S42D35T11-06L02 189:N41D24S20H06Q02T02

190:S40Y26A09T07N03D02K02F01P01 192:I62Y33H01V01 193:K31L24R20Q19S02 194:A96T02 195:V90I09 196:Y55S28F05H02A02R02G01 197:D79E18N01 199:T42S42C11N02

200:Y42L33N08H06F02D02C01M01R01 201:L90M08 202:V44M29I12L07T03A01 203:Q35S27N13H12F07 204:Q46N18L11E07D04H03S03K01F01 206:I49L25V12F05M04T02A01

207 :R38Q23E 18D08 V02H01K01 AO 1 208 : S35T24N14I09F04 V04M02 AO 1 209:F88 A02L02P02Y01 210:Q33P26S25L08F03 211:Y87F05H02L02P01 212:H80-14Q03 213:N58K24S14 214:D95I01N01 215:F38V23L20I11T03A01 216:I62F28L07V01 217:Y85F13 218:W47D17Y09N08H05S03R02G01Q01 219:L87F08M01I01R01 220:T66S33 221:P65R19S06H04L01 222:H58K23Q08A03N02S01

224:R70Y12F12H03 225:R56E15Q10D05W03N02K01T01 226:F85Y09T02L01 227:R38L34Q22H04 228:R37K30D23E05N02 229:A94V03 230:C96Y02 231:K44Q41R12 232:L44V32I14A05 233:A97T01 235:D39T22Q09S09L04N04A03R02E02H01 236:H98Y01 238:D88E08Q01 239:K47Q33E12H04N01 240:V97I02 242:K42R41Q10H04 243:E71K15Q06L02 246:A34E31M24T04K02I01

247:A42L30S18Q02V02M01 248:L97F01 249:Q35K34S26C01 250:D49S18N12E09K05G02 251:E92K06 252:K66R17E04G03T03N02-01 253:E94V02 254:L51Q25F08R06W03H01S01 255:E54D29K07G03S01 256:K85R09N01 257:I91V03T02L01 258:Q87K05R02L01 259:K55N21A07Q05S03R02H02 260:K69R27Q02 261:R91K08 262:H82N08Y05R02 271:C52G33F07L04S01 272:A69T18S06V04 273:K56R39Q02

274:D94M02S01 275:E76A21 276:N75S08D07E01K01Q01T01 277:G80Q10D02K02

278:V30I28A14Q10S04T03E02K02N01 279:G57K30A03I02N01S01 281:S98P01 283:E63A29K04M02T01 284:D96E02 285:L89I09 286:R97Q01 295:E85A14 301:A63T34S01 303:G94A02S02 304:I94L04

305:S96C02A01 306:W91F08 307:L44F33I17V02M01 308:L74F25 310:C92A03S02 311:M60L39

312:A74S25 313:L66C10S06K03T03Q02M02I02R01 314:Y51H37N09Q01 316:E91K06D01 317:H79Y20 319:Q57H17K08A05E03R03D01T01 320:R77K07Q05I04L04 323:E88K04D03N01 325:I70V24A04 326:Q47R25K08M06C05H04L01 327:E57G31Q02S02D01 328:I78V11A05L03 330:G84D06Q04E03H01 331:D78G14N02E01S01 332:R71K12Q11G04 333:D84E07A03N01 334:T63S32A02 335:I48F26V12M07L04 336:Q51E37D05T04K01 338:E58D38N03 339:D95H04 341:G76S10N05A04D02 342:K94Q04 343:M84I15 344:T77P20 346:T53L34S09C01 348:M96L02 350:I98M01 353:S89C05A03T02 354:L65F33M01

356:L97M01 357:Y70F28 359:P96A02 360:V98A01 362:G36Q35S18A05F02 363:V82I15M01

364:S54Y32A05F03G03 366:Q61Y14K09E09C02H01 367:L92I05T01 368:S80T12N04H01

369:K92T02S01Q01 370:P90S07A01 371:V67I25M05L01 372:T76N12S08

374:V32S22P17F16H04A02I02C01 378:S71T27 379:L94V05 381:A67E27K04 382:G98D01

383:S53C30T04I03F03L02 384:L46Q24I10H05M03V03K01T01Y01 385:V57I32A05T04 386:S46G34A12L02F01V01 387:L59V16I15M03T03 388:H35S33N30 389:I91V06M02 390:Y61F37 391:A74G13L09C01S01 392:I48L47T02V02 394:R92H05K01 396:R29P29S29A07G02Q01

397:A28D27T20S13E04K03N01 398:V96I01 400:E47P33K13S02T01D01 401:D78N20 403 :E80L08N05H02 404:V84I11M02 405:F73Y26 406:D97N02 408:L83M06Q04F03 411:S82L12A02T02 412:P92S02L01T01 413:E95G02 414:N94-02K02 415:S47V33A07T04-02I02M01 416:A47S40T09V01

417:G34Q30K16R08T03A02N01 418:R95Q03 419:H88S10 420:S52P47 421:H60F32Y07 423:F98Y01 424:L53M22V15I08 427:S85A14 428:A96G03 430:P56S31M05A04L01T01 436:Q97K02 437:Q83N11T03 441:N89I02M02S02 443:M82L10I05V01 446:A56V41 447:L46T40V07I02A01S01 449:L93M05

450:T62C33I02 452:L82K11N02Q02 453:R88H05K04 454:F86Y13 455:E87Q06K02H01V01 456:L64F33 457:S42C17A12I10L06Y02F02R02H01 458:P61L22E07V03Q02 459:D93N04E02 460:P92L04H01 461 : S54 Al 5T 13L08D05N01 462 :K42R30Q 10N05L04T02H02 463 :P61L20K07I04T04 V01

465:I55T15K14L03C03A01V01 466:K43L23P15M10I05 467:I58M20L08V04T03Q02

468:P82L05A04T04Q02 469:Q79R19 470:L61I33V03 471:V59I38T01 473:R87K11 475:K51S26L11R04Q02 476:N93T03S02 478:I95F02V02 479:H96Y02 480:L83I11V04 481:H62K13Y09R05F03N02L01 482:L86I12 483:K92R05 484:K53P33S07R03L01 485:L46I34V15A02 486:G23H20R14Q07E06D05P05C04F02- 02S02N01T01

(iii) N122

2:L54V27A09F07I01 4:L94V04 5:L97I01V01 6:L50F32I12V01 7:K98Q01 8:A85V09T01G01 9:A74V21I02 10:Q98H01 11:L63F33H01 12:Y98F01 13:L93Q02I01V01 14:H67R21K03C02Q01 16:Q97R01

17:W89R08C01 19:L97F01V01 20:K83R15 21:A83T07V04D02 22:L57V20F15T05 23:Q90H07E01 24:Q79E06H04K04S02L01N01 27:S66C25G05 28:P87T08A03S01 30:S85F08A03T01 33:L74F25

34:F63Y25L05W04 36:H96D01N01 37:K32S30I09N05-05H04F02M02Y02V01Q01 38:R40Q26K12L08- 04W03H01 39:E65Q19Kl l-03 40:F67L10I08V07Y02H01 41:Q77P07G03K02L02S01R01

42:K47Q14E12G03N03I03P02R02V02D01M01S01T01 43:D69E18G07N03K01

44:Q67S08E06K05N04G01T01D01 45:E96D02G01 46:L98I01 47:Q82P08E03R01H01

48:Q47R11P08E07K07D05L05H02V02 49:I51L29V07T05F02M02 50:L74Q13R05M03A01V01

51:K72T16S05E03 52:W65R27C04L01 53:V76A16I03T01M01 54:E83K13Q01 55:K64N12E09T09 56:F76Y22 58:S64C25R04K03T01 59:A97G01 60:C76F16S04Y02 61:P78A07L05S04V03

62:R69H12Q10L03Y02 64:L69F23M03I01V01 65:W83S09G03R01 66:G98P01 67:S56T26G07F04N04 68:K67R14E03M03N03S02C01 69:V45A41L06P01T01I01 70:R28H23L10F09S07T05Y05Q03M01E01I01 71:L40V40F12I05 72:L38Q21M13I10V07T03S03N01 73:V54L22I21 74:Y98H01 77:D96E03

79:M83I07V04A01L01 81:V80M09L06T01A01 82:I80V18 84:G93S03A01 85:R97K02 86:S92R04P01 87:D98E01 90:A49S39P05D01N01V01 91:H57N10S09D04P03R03Q03I01K01

92 : G64D 10S06 V05R04 A02I01E01K01 93 : S48T2 II 12 V05 A05F01L01N0 IPO 1 94 : Y94H03 SO 1

95:R78K12S02G01Q01T01 96:F69L26Y03 97:L83V06M05F01I01 98:A69I08S08T05V03K01N01 99:P96S02 101:I97L01 103:Y80T07K05C02N02 107:L92V05M01 109:N84E10D03 111:Q74K07P07E06S03

112:T63K16P14M02A01E01 115:Q94E04 116:H97R02 119:M93L05 123:A98G01 126:Y93F02S02H01 127:D94G01N01S01 131:P94A03S01 133:V97L01 134:G60A12R12E07K05N01 135:L51I29T07V07F01N01 136:M93V03I01T01 137:A90V07D01 138:D84N13K01 140:V93I03A01 141:R63Q21N07H03K01

142:V82I05L05T03A01G01 145:D96N01 146:K94R05 147:W96L02 148:E96Q01 149:E41Q38K14R01D01N01 150:L90I05F01 151:I40V26L13A07D05S05T01

152: S47G33T06D04R03 AO 1N01 153 : Q91E02L01H01K01 154 :D80N14G01Q01 SO 1

155:S83H03N02P02T02A01 156:P39H25S25T05 157:L86V07I04 158:E96D03 159:I85V14

160:F90L04S01V01 161:Q52E21G19H04R01 162:H83P05Y05D03S01 163:V67I31 164:S98T01

165:L94S03M02 169:D96E03 170:T83S16 171:I85V09L05 178:H70Y27Q01 179:Q85K06E05H01

180:G87S10D01T01 181:S78N15C04 182:V60I16H07A05C05T01 184:L41T25V12A08M06F03S01 185:D94E01N01G01 186:R74G11E06S03K02 187:N71S08K07D04H01I01 188:S85Y10I01

189:Q70R10H07K05N04 190:S87P03T03A02 192:I85T07L06V01 193:Q85K12H01 195:I74V23T01 196:G29R21E19S10D02H02I01K01Q01W01Y01M01T01 197:D89N05E04 198:L92M03I01V01

199:N67S14K12T02G01A01 200:N70H07Y06D05S04K03T01 201:L96M01R01

202:F34V31T12I09L05A02M01S01 203:F77Y05H04V04S03L01I01 204:S74F10A03H03Y02C01T01 206:V58L17I14M05A03 207:R94K02 208:N89S09T01 209:V41A36I12F03L01M01 210:F94L05

211:H56Y39L02Q01 212:Q85H08K03E01 213:N81S09K05D01 214:D91N08 215:T50I32L09F04H01 216:I90L03V03F02 218:R37S33G10N09W05K03 219:L87M06F05 220:T53S45 221:S48P44T04R01 222:E44N26A12D08Q03S01T01 224:R89H06Q02 225:W42L25R18Q07K04S01 226:N28T20F18A17S13C01 227:H56N13K12R05Y03Q02I01S01L01 228:R67Q11H07S05K04Y02 229:A96N01 230:C88Y04A02S02 231:Q83K07R04E01H01 232:L78I14V03R01 233:A96I01T01V01 235:Q47E40D10 236:H94Y05 238:D98E01 239:Q41R36A09G09K02E01 242:K60Q29R10 243 :L52Q20E10M06S05R01K01 245:K97R01

246:A81S05D05Q02E01 247:Q67H27S01R01 249:Q90K05E01R01 250:D32K29E19N09Q07-01

251:E92Q03A01 252:G82E07R05K01N01 253:E94D01G01 254:L92M05Q01 256:K93N03A01T01

257:V68I28A01L01 258:R55K36S04Q03 259:K41R34S12Q04G02N02 260:K91R07 262:H68R29C01 268:I94V05 271:F76L16C05R01 272:A95S03 273:K51R45Q02 274:M85T07S01R01V01 275:E96K01 276:N81D14S01 277:G98E01 278:S70N12D09K03E01R01 279:S81I08G05R01N01 280:L95F03 281:S97T01 282:D92N05Y01 283:K65E18T06Q05A01V01 284:D96E03 285:L97I01 295:E94A03G01 302:S98T01 303:G98A01 304:I92V06L01 305:S98C01 307:I87L04T04V03 308:L66F33 309:Y97H02 310:A96C01 311:L98M01 313:T62S20A09M06 314:H94N05 315:P98S01 316:E74K22D01 317:H98Y01

319:Q84E07H06K01 320:R84K14 323:E96K02 325:I56V40L03 326:Q84H07R05L01 327:S76G20N01 328:L88I08V03 330:G96A02 331:D96N01 332:G95E03 333:A66T18S09D02G01 334:S95P03A01

335:I92V05L02 336:T93S05 338:D68E16N10H01G01 339:H96D01L01 340:L98M01 341:D92G05N01 342:Q90K07 343:M96I01L01 344:P98S01 346:T98M01 353:A93S05 354:L89M10 356:L93I05 360:V94I05 362:G39S33A10V09N02R01T01 363:V49I49 364:G46S40V09A01 366:E83D09Q03K01M01 367:L97M01 368:S87N08K02 369:K61T29S05E03 370:P95S01T01 371:V49I49 372:T96I02 374:P98S01 377:R97K01 378:S96I01 380:P98T01 381:K74A20E01R01 382:G98D01 383:I76F09V06T03N01M01

384:I32T23S12L11M09P03Q02H01V01 385:V87L06I05 386:S45T23L12V06A04M03F01I01 387:L92I05 388:S90N05H01 389:I63F35L01 390:Y98H01 391:G53A40T05 394:H98Y01 396:P98S01

397:K66R09N07T07D02Q01S01E01 398:V92F05L02 400:P96E02 403:E92K04Q02 404:V94E04 405:F95Y04 406:D98N01 408:S76F13L05T03 411:A91S07T01 412:P93L01V01A01 413:G51D32E09A01S01 414:N52-47 415:L49-47S01 416:S85A07T04V01 417:A41S25T18P05D03L01R01N01 418:R74Q23Y01 421:H97Y01 422:A72S27 423:F97Y02 424:L98M01 428:G89A10 430:S67A25P05 436:K93Q06 437:Q94H03K01 441:N92S02I01K01 443:L63M34I01 446:A90V05I01 447:V87T07L04 450:T96I03 452:L98V01 453:R97L01 455:E98K01 457:L59A29S07K01E01 460:P94S01T01A01 461:T58S30F05M02 462:R90K08Q01

463:V49I42P05T01 465:I44V35L08F03D01N01Q01T01 466:P92L05

467:I45M14T13V09L05S05W01F01K01 468:P56A26S05L03Q03 469:R73K08Q06V04E01G01N01T01 470:I47L37V08M03A01S01 471:V95T01L01 473:K78R11M07E01N01 475:K83E07S03T02N01Q01 476:N94D02E01 479:H84Y13 480:L98V01 481:H49R27Q09Y05K03C01W01 482:L97M01 483:R69K29 484:K85R12 485:L92I05 486:H25P22Q16L13S07K05R05-01

(iv) N198

1:L93M04 2:A80S07L05T05 4:G57V19L18A02 6:L88I04M04F01 7:Q92K07 8:A79V17 9:I86V10A01 10:K86Q06R06 12:Y94F02H01 13:L91Q07 14:R84Q08H04K01 16:Q85R08L04 17:R84W05Q04G02 19:L93I03Q02 20:R93K05 21:D79A16E01V01 23:R75C07H07Q06 24:P53L16C09A05Q04R03H01 27:A58G23T07C04S04 29:P94S05 30:T57A27P06S04 33:F54L44 34:Y50H22F10L10T04 36:H97N02 37:Q80K05I04N01S01V01 38:K82Q06E05R04 39:F51L35E09V01 40:L60F22I07Y07

41:Q77P07R05K03Y02 42:D48E34Q07L02V02N01 43:D53G28K07E06N01 44:E49-43Q04K02

45:K49E34N08D05 46 :M70F14L 10102 47:E87Q09K01 48:K78R04Q03I02S02N01T01V01 49:L75F10I06Y06 50:E69D10N06Q04G01H01L01 51:E86K09V01 52:L40I37F09W06T03V01 53:V86I07M04

54:E84K10A01G01 55:K91T04N01 56:Y95F04 58:C80R11S05 59:A97G02 60:F87V05C04

62:C50R17L14H05A04F04 64:V63I28L04F01 65:G95W0466:P91G04A02 67:F95G04

68:Q78T05E04K04M02 69:A76V16M06 70:F88L04R04 71:F81L13V04 72:Y60F16Q09I06N04

73:I90L04V03 74:Y93H03C02 77:D89E09 79:A92M04V01 80:K93Q04 81:T65I18V07M05A01

82 :F75L 15106 V01 84:S67N19G10K01 86:T80K06R05S05 88:P94L02S01 90:S79T15I02

91:Q60K17T08H07N02R01 92:Y60F16I06G04L03V02C01H01 93:L52P21S13V06G02

94:Y56H18N10Q05C03S02 95:K67R23Q07 96:F90I06L01 97:L59M29I05T01

98:T38I28S11A05E05V03M02P01 99:P84S12A01 100:C59W18L10S04T01 101:I46L40V09T01

103:K62R12Q10E06Y04 106:L59V37 107:N54S24T07A04L04V01 109:D72N11E08H04S01

111:P78S06I04Q04K02 112:K77R13T06 114:F83S07Q03Y02K01 115:Q96K01 118:R62H15C11Q07 119:L87I06M05 120:L84V08I05 121:T89K07M01 123:G74A23V01 124:F92L06 125:H67N20S05Q04 126:F49C12L11I06V06Y04H02S01 127:N62D24S12 128:I84T12 130:K97T01 131:T30S28P26I06A05L01 132:Y76F10C06H05 133:V70I17T05A04 134:E59D07T07G05A04K04S04H02 135:V72M12L08A01I01 136:M98I01 137:A71V10S05N03T03I02 138:H62Q15D10E06C01 141:N72R14K06C02

142:T65V17I08M03R02 145:D67G22A04N03 146:K97T01 149:K86E10R01 150:I66L18M10H01V01 151:C62L15I09W04S02R01 152:S36G35I10T09A05 153:T62Q18S08A07P01 154:D67E14H10N06

155:T72S17P05A02 156:T42V10S08I07L07A06H05P05 157:V70L26I02 158:E92D07 159:V81I14L02 160:F59Y28S03C02 161:E87Q06K02 162:H87D08P02 163:I91V08 164:N54S32D06R03 165:L98M01 167:T56A32S10 170:I67S11T11V07 171:I54L45 172:M86L12 173:K92Q05 175:A85I07T05

177:S78T09G08N02 178:Q63H13K08W05R03V02 179:E80Q16K01 180:T87G11 181:N83S14D01

182:C84I10S02 184:I68T23V04L01 185:N67D19S09E02 186:S65G27R06 187:T74S10N08F02

188:H44Y17S12N09L07C01F01 189:D79E06Q04N02T01 190:P50S15L14Y06N04H03

192:V62L15I12E02M02T01 193:K84E05Q04S02N01 194:A86T07G04 195:T47M19I15V13L02

196:F62S17C04L04T04V01Y01 197:E78D09N07K02 198:L64A15G10V02M01S01 199:S57G24N10A01D01 200:K66E12N11R04Y01 201:I80L17 202:I63V14L07T07S02 203:F77S09Y06I02M02 204:Y51H16S12Q11N03 205:R93H04 206:L65M15V13F01 207:Y74R06F05N05H04 208:N53S44

209:F83Y07A04 210:L69W19F10 211:H68Y19D04N01 212:H94Q04 213:H58N22S06Y06C01

215:I62L24T05V02M01 217:F87Y12 218:K76N12S04R02W01 219:F73L22W02 220:S93T06 221:P80S19 222:Q41E19K18L06A05M04N01 223:G91K04S02 224:H69R12Q11Y05 225:R71C06I05H04W04E02L01 226:F63L29T04 227:Q77R07S05H04 228:E60K31R04A02 229:L57I15M07A06F05V02

230:S49N15C10V08G06I03R02 231:Q50K40N04E01R01 232:V62I23L06N03M01 233:L81A09I05T01 234:H87Q03Y03N02R01 235:Q93H03 236:Y75H15C05F01 237:T92A04I01 238:E72D26

239:K79Q11T04N02 240:I57V39L01 241:I82V14L02 242:Q88K05R03 243:D77E13L04N03 245:K83R14 246:K71E09N08A04D01 247:S66A08L07F06Q04 248:L95I02 249:K70Q22E01R01

250:D50A21N11K04S02T02E01 251:E58G32D03 252:K24M19R16V13L06G04N04S02T01

253:K76E17N02R01 254:Q81H11L04 255:D66G16E07A02T02 256:N56K16T12D07S02 257:T82I11A01V01 258:Q84K04G03R02D01 259:K83R05N04-03E01 260:R63K18-11Q04 261:K75R15E02N02T02

262:Y80H08S04F03C01 263:Q79L09R08 264:D98N01 265:F93L05 268:I92V05 269:V52L28I16

271:S82C04G04L04A01 272:A97V02 273:Q75K22R01 274:A68S12D10M04 276:N78H06D05S05I01 277:G59E24R04-02D02A01S01 278:D52N13S10E07K07R03G02 279:S70I07D06G06A04 280:F89L10 281:S92T04P02 282:D89E07N01 283:T47A36E06K04I01 284:D95E04 285:L84V13I01

286:R34Q28W14H07E03L03Y02M01 287:S72A27 289:V95M02 290:N72S12K07D06 291:T96M03 293:M73I11L09V04 294:L60F20V08W08 295:A86E06G03 297:H90Q08 298:D91E02S02N01

299:T72A15S11 300:T48S18V14M13L04 301:A82S10G03 302:A39G37S19V01 303:S50G39A09 304:I69L30 305:S95A02T01 307:L79I16V02 308:L95F04 309:Y97H02 310:C66H18A04F03Y03 311:L90M09

313:L69Q09K06M06T04 314:N72H13Y12 316:E93K04 319:E61Q25D08H03 320:R89K07Q02

323:E85D07T06 325:I92V06 326:R89H04K02M02 327:G42S35D08A06E05 328:I79L11T06V01 330:G94K02 331:D87E04N03S01 333:S83D07A05P01 334:S94T02A01 335:I96T01 336:T79I08H04S03N01

338:D84E09N05 339:Q60H38 341:G51D28S14N01 342:E79Q18 343:M97L02 344:S71P19T05

346:T95S02I01 347:T97E01 351:K94S02Q01 353:S35A22T20M13C06 354:L72F25C01 356:L95I01M01 357:I50A22Y21C02 358:P98S01 359:P86T07A05 360:V67I19A08E01 361:P80V04F03I03L02

362:S85G04T04N01 363:I93L03V02 364:S88A06G04 366:E78Q07D05L05 368:S90N06D01

369:K89T04Q03E01 371:I52L40V05 373:F91L08 377:R74H14C09 378:S91T05 381:A90K04T04

383:M55I37V03T02 384:T68N18I05M04 385:V97L01 386:V80F06L06T03 387:L98I01 388:S80N19 390:W92Y06 391:G86A13 397:A78T11K04D01Y01 398:V56I40F01 400:E56K31N05P04 401:N72D12S11 403:K68Q21E09 404:V98I01 406:D90N09 408:L87F05S02Q01 411:S76T18A04 412:Q40K29P24R02L01 413:E89D04G04 414:N94-04 415:S83-07Y02Q01 416:D76N06E04S04M02T01 417:Q70K21A04R02 418:R93Q04I01 420:P68S29 421:H57Y35C06 422:A76S23 423:F87Y12 424:L93I06 425:P93T03A02 428:A79S10G05T03 430:P79S19 432:N87D10S01 436:Q93K04E01 437:Q66H25N06 438:F94L03

440:M92I07 441:141 V22L21A04N04T03 442:E86Q11 443 :L82C07I05M02 445:V97M01 446:A87I04T03G02 447:I60V17L11T05M03 449:L95M04 450:I81T16 453:R73H24 455:K41E30R17Q10 456:V69L19M05I04 457:T52A22S10L05R02V02 458:P86V05L02A01S01 459:D92E04A02 460:P70L19H05S02

461:T84S07E02P02 462:R85K11T02 463:P94I04 464:P54L41V02 465:I31V24A21T12S03Q02L01

466:F59L18P16I02 467:S49L18I13V10M06 468:P42N28S10R07A04H04 469:H42Q41R07K05

470:I55V18L08F05T05M02 471:V68I16F06L05A01 472:L92I04 473:K87R10 474:P63S30A05 475:K95Q03 476:N71H13D09K04 478:I57V20M12L08 479:H73Y26 480:L93V06 481:H55C12R07F06Y06S04 482:L97V02 483:K89R05E03 484:K91R04P02 485:L77I19V01 486:P59S23H07C05T02

Table 5. Thermostability of extant and engineered ancestral P450s. Data presented represents the mean 1⁰T₅₀ and ⁶⁰T₅₀ ± standard deviation of independent experiments on three to four biological replicates. Ancestral forms are shown in bold for clarity.

Table 6. Dissociation constants (Kd) for binding of selected CYP2B substrates by ancestors of the CYP2B subfamily.

Table 7. Expression levels (nmol L) of CYP2 engineered ancestral enzymes cultured in 50 ml baffled flasks.

Table 8. Identified ligands of selected CYP2 engineered ancestral enyzmes.

P450 Type 1 Ligands Type 2 Ligands

CYP2_N312 (CYP2A) Celecoxib, chlorzoxazone, Donepezil, tacrine

clopidogrel, ethinylestradiol

CYP2_N133 (CYP2C) Celecoxib, ethinylestradiol Fluoxetine, rosiglitazone, tacrine, midazolam

CYP2_N77 (CYP2F) Tacrine, rosiglitazone, ritonavir, pioglitazone, nevirapine, verapamil

CYP2_N69 (CYP2CE) Atorvastatin, celecoxib, Ritonavir, tacrine

clopidogrel, ticlopidine

CYP2_N23 (CYP2CEH) Celecoxib, donepezil,

midazolam, ritonavir, tacrine Table 9. Metabolite (M) peaks identified from chromatograms following incubations of CYP2 engineered ancestral enzymes with testosterone.

Table 11. Expression levels (nmol L) of engineered ancestral CYPl proteins and selected extant CYPl proteins cultured in 1 mL microplate cultures.

P450 nmol/L

Human CYP1A1 <50

CYP1_N98 230 +/- 70

Human CYP1A2 74+/" 12

CYP1_N127 8 +/-16

Turkey CYP1A5 90+/-14

Human CYP1B1 134 +/-22

CYP1_N17 205 +/-15

CYP1_N18 450 +/- 120 Table 12. Relationship between CYPl A2 sequences, and CYPl AO and Al sequences.

Node Ancestor grouping

N9 1ADBC

N13 IAD

N18 ID

N14 1BC

N27 IB Actinopterygii

N20 IB

N207 -

N72 -

N98 IB Mammal

N25 1C Actinopterygii

N58 ID Mammalia

N53 -

N52 1A Actinopterygii

N17 1A

N21 1A Mammalia & 1A Reptile & 1A Amphibia

N134 -

N223 1A5 Aves

N224 1A4 Aves

N29

N46

N45

N128 1A1 Mammalia

N127 1A2 Mammalia

Table 13. Relationship between CYP2 A2 sequences, and CYPl AO and Al sequences.

AO/A1 A2

N3 -

N8 -

N13 -

N24 -

N38 -

N54 -

N81 -

N82 2BSAG

N118 2AG

N159 -

N200 -

N312 2A_Mammal

N117 2BS

N157 2B_Mammal

N196 2S_Mammal

N37 2 FT

N77 2F_Mammal

N112 -

N23 -

N35 -

N47 2CEH

N69 2CE_Mammal & 2C_Reptile & 2C_Aves

N70 2H

N140 -

N98 -

N218 2C Aves

N133 2Cl_Mammal

N134 -

N169 2C2_Mammal

N170 2E_Mammal

N97 2CE_Mammal REFERENCES

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Claims

1. An isolated protein comprising the amino acid sequence set forth in any one of SEQ ID NOS: 1- 159, or an amino acid sequence at least 80% similar to said sequence, or a fragment or derivative thereof.

2. An isolated protein comprising the amino acid sequence set forth in any one of SEQ ID NOS: 1- 23, any one of SEQ ID NOS:64-94, any one of SEQ ID NOS: 142-151, or any one of SEQ ID NOS: 152-

155, or an amino acid sequence 80% similar to any one of these, or a fragment or derivative thereof, wherein each amino acid sequence comprises residues Xi - X_n _ as defined with reference to Tables 1 -4..

3. The isolated protein of claim 2, wherein one or more of the residues Xi - X_n is selected from the respective group of variable amino acids as set forth in:

Table 1 with respect to SEQ ID NOS: 1-23;

Table 2 with respect to SEQ ID NOS:55-85;

Table 3 with respect to SEQ ID NOS:134-144; or

Table 4 with respect to SEQ ID NOS: 145-148.

4. The isolated protein of claim 3, wherein each of the residues Xi - X_n is selected from the respective group of variable amino acids as set forth in:

Table 1 with respect to SEQ ID NOS: 1-23;

Table 2 with respect to SEQ ID NOS:55-85;

Table 3 with respect to SEQ ID NOS134-144; or

Table 4 with respect to SEQ ID NOS145-148.

5. The isolated protein of any of the preceding claims, wherein said isolated protein has P450 activity.

6. A method of producing or constructing an isolated protein, said method including the step of producing or constructing an engineered ancestral amino acid sequence of at least a fragment of a P450 protein from one or more P450 proteins comprising amino acid sequences that are different to the engineered ancestral amino acid sequence, wherein the P450 protein is a CYP1, CYP2, CYP4 or CYP4F P450 protein.

7. The method of claim 6, wherein the engineered ancestral P450 protein produced according to the method displays or possesses one or more increased or enhanced properties compared to at least one of the one or more P450 proteins comprising amino acid sequences that are different to the engineered ancestral amino acid sequence.

8. The method claim 6 or claim 7, wherein the engineered ancestral protein comprises an amino acid sequence set forth in any one of SEQ ID NOS: l-159.

9. A method of producing or constructing a modified engineered ancestral P450 protein, said method including the step of introducing one or more amino acid substitutions in an amino acid sequence of the engineered ancestral P450 protein to thereby produce or construct the modified engineered ancestral P450 protein, wherein the engineered ancestral P450 protein is a CYPl, CYP2, CYP4 or CYP4F engineered ancestral protein.

10. The method of claim 9, wherein the one or more amino acid substitutions is introduced into any one of the amino acid sequences set forth in SEQ ID NOS: 1-159.

11. The method of claim 10, wherein the one or more amino acid substitutions is introduced into any one of the amino acid sequences set forth in SEQ ID NOS: 1-23, SEQ ID NOS:64-94, SEQ ID NOS: 142- 151, or SEQ ID NOS: 152-155.

12. The method of claim 11, wherein the amino acid substitutions are at one or more of the residues Xi - X_n, with reference to Tables 1-4.

13. The method of claim 10, wherein the one or more amino acid substitutions is introduced into any one of the amino acid sequences set forth in SEQ ID NOS:24-63, SEQ ID NOS:95-141, or SEQ ID NOS: 156-159.

14. The method of claim 13, wherein the amino acid substitutions are at one or more residues corresponding to Xi - X_n of a respective sequence set forth in SEQ ID NOST-23, SEQ ID NOS:47-63, or SEQ ID NOS: 152-155.

15. An isolated nucleic acid encoding an isolated protein, fragment or derivative of the protein according to any one of claims 1-5, or produced according to the method of any one of claims 6-14. .

16. A genetic construct comprising the isolated nucleic acid of claim 15.

17. A host cell comprising the genetic construct of claim 15.

18. An antibody or antibody fragment which binds and/or is raised against an isolated protein, fragment or derivative of any one of claims 1-5, or produced according to any one of Claims 6-14.

19. The antibody of Claim 18, which does not bind, or binds with substantially reduced affinity, an extant CYPl, CYP2, CYP4 or CYP4F P450 protein.

20. A composition for performing a chemical reaction, said composition comprising one or more isolated proteins, fragments or derivatives of any one of claims 1-5, or produced according to any one of Claims 6-14., and one or more buffers, solvents and/or other reagents suitable for performing the chemical reaction.

21. A method of performing a chemical reaction, said method including the step of exposing one or more substrate molecules to one or more isolated proteins fragment or derivative of any one of Claims 1-

5, or produced according to any one of claims 6-14, or the composition of Claim 20. to thereby perform the chemical reaction.

22. A reaction product produced according to the method of claim 21.

23. Use of the isolated protein fragment or derivative of any one of claims 1-5, or produced according to any one of Claims 6-14, or the composition of Claim 20 for biocatalysis, preferably for structure-activity relationship analysis; pharmacological testing; bioremediation; or biosensor technology.