WO2016153222A3 - Pharmaceutical composition comprising potassium salt of telmisartan, and preparation method therefor - Google Patents
Pharmaceutical composition comprising potassium salt of telmisartan, and preparation method therefor Download PDFInfo
- Publication number
- WO2016153222A3 WO2016153222A3 PCT/KR2016/002743 KR2016002743W WO2016153222A3 WO 2016153222 A3 WO2016153222 A3 WO 2016153222A3 KR 2016002743 W KR2016002743 W KR 2016002743W WO 2016153222 A3 WO2016153222 A3 WO 2016153222A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- telmisartan
- preparation
- present
- formulation
- pharmaceutical composition
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
Abstract
The present invention relates to a pharmaceutical composition containing a potassium salt of telmisartan, which is an angiotensin II receptor antagonist, and a preparation method therefor. The present invention can provide a granule or powder form of a solid formulation with improved drug dissolution and stability of a telmisartan-containing formulation, and a method for preparing capsules and tablets containing the same. Also, the composition and preparation method according to the present invention are industrially advanced techniques which allow for very easier preparation of telmisartan as a single component or a composite agent combined with other diuretics or high blood pressure-related components compared to a pharmaceutical composition containing telmisartan or salts thereof, thereby achieving significant improvements in terms of production time and cost. The size of a dosage formulation can also be significantly reduced compared to conventional formulations, thereby enhancing medication compliance of patients taking the formulation for a long period of time. In addition, the present invention can provide a composition containing a potassium salt of telmisartan which is capable of significantly improving hygroscopicity of a product, which has been a problem of existing formulations, and maintaining stability in typical packing materials.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2015-0038969 | 2015-03-20 | ||
KR1020150038969A KR20160112732A (en) | 2015-03-20 | 2015-03-20 | Pharmaceutical compositions comprising potassium salt of telmisartan and Preparation methods thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2016153222A2 WO2016153222A2 (en) | 2016-09-29 |
WO2016153222A3 true WO2016153222A3 (en) | 2016-11-17 |
Family
ID=56978240
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/KR2016/002743 WO2016153222A2 (en) | 2015-03-20 | 2016-03-18 | Pharmaceutical composition comprising potassium salt of telmisartan, and preparation method therefor |
Country Status (2)
Country | Link |
---|---|
KR (1) | KR20160112732A (en) |
WO (1) | WO2016153222A2 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021148347A1 (en) * | 2020-01-20 | 2021-07-29 | Zakłady Farmaceutyczne POLPHARMA S.A. | Bilayer tablet comprising telmisartan and amlodipine |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20070061583A (en) * | 2004-10-15 | 2007-06-13 | 테바 파마슈티컬 인더스트리즈 리미티드 | Process for preparing telmisartan |
WO2007147889A2 (en) * | 2006-06-23 | 2007-12-27 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Preparation of telmisartan salts |
KR20100128247A (en) * | 2009-05-27 | 2010-12-07 | (주)다산메디켐 | Multi-layer tablet comprising effervescent layer |
KR20110085307A (en) * | 2010-01-20 | 2011-07-27 | 한올바이오파마주식회사 | Oral solid dosage form comprising poorly soluble drugs |
KR101302883B1 (en) * | 2012-07-23 | 2013-09-05 | 삼일제약주식회사 | Pharmaceutical composition comprising telmisartan with improved stability and preparation method thereof |
-
2015
- 2015-03-20 KR KR1020150038969A patent/KR20160112732A/en unknown
-
2016
- 2016-03-18 WO PCT/KR2016/002743 patent/WO2016153222A2/en active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20070061583A (en) * | 2004-10-15 | 2007-06-13 | 테바 파마슈티컬 인더스트리즈 리미티드 | Process for preparing telmisartan |
WO2007147889A2 (en) * | 2006-06-23 | 2007-12-27 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Preparation of telmisartan salts |
KR20100128247A (en) * | 2009-05-27 | 2010-12-07 | (주)다산메디켐 | Multi-layer tablet comprising effervescent layer |
KR20110085307A (en) * | 2010-01-20 | 2011-07-27 | 한올바이오파마주식회사 | Oral solid dosage form comprising poorly soluble drugs |
KR101302883B1 (en) * | 2012-07-23 | 2013-09-05 | 삼일제약주식회사 | Pharmaceutical composition comprising telmisartan with improved stability and preparation method thereof |
Non-Patent Citations (1)
Title |
---|
REDDY, K. S. ET AL.: "An Efficient and Impurity-Free Process for Telmisartan: An Antihypertensive Drug", ORGANIC PROCESS RESEARCH & DEVELOPMENT, vol. 11, no. 1, 2007, pages 81 - 85, XP002548424 * |
Also Published As
Publication number | Publication date |
---|---|
KR20160112732A (en) | 2016-09-28 |
WO2016153222A2 (en) | 2016-09-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NZ631100A (en) | Soft chewable pharmaceutical products | |
EA200901146A1 (en) | SOLID MEDICINE FORMS CONTAINING ALISKIREN AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS | |
EA026238B9 (en) | Stable combination pharmaceutical composition | |
PH12015501301A1 (en) | A pharmaceutical composition containing candesartan cilexetil and amlodipine | |
PH12015501377A1 (en) | Solid unit with high fexofenadine content and process for the preparation thereof | |
WO2016153222A3 (en) | Pharmaceutical composition comprising potassium salt of telmisartan, and preparation method therefor | |
PH12017501831A1 (en) | Pharmaceutical compositions for oral administration | |
WO2014125504A3 (en) | Pharmaceutical compositions of febuxostat | |
EA033291B1 (en) | Dosage unit comprising ramipril and bisoprolol hemifumarate, process for the preparation thereof and method of treating hypertension | |
RU2015113031A (en) | The use of 3-n-butyl isoindoline ketones in the preparation of medicines for the prevention and treatment of cerebral infarction | |
CN103860511B (en) | A kind of Pharmaceutical composition containing Irbesartan and Amlodipine Besylate Tablet and preparation method thereof | |
WO2018069805A3 (en) | Method for preparation of liquid oral composition of l-thyroxin | |
MX2015015681A (en) | Pharmaceutical composition comprising fingolimod. | |
WO2012141615A3 (en) | Medicament | |
RU2013107724A (en) | PHARMACEUTICAL COMPOSITIONS OF MONTELUKAST AND LEVOCETIRISINE | |
WO2016204657A3 (en) | Method of producing a pharmaceutical composition of ademetionine and a dosage form thereof | |
MX2017012633A (en) | Process for manufacturing dry powder blends. | |
WO2016139681A3 (en) | Pharmaceutical composition of tizanidine and process for preparing the same | |
WO2023129069A3 (en) | A pharmaceutical composition comprising naproxen and esomeprazole | |
MX2015013330A (en) | Combined pharmaceutical composition for preventing diabetes mellitus complications. | |
WO2015086918A9 (en) | Novel process for producing transmucosal pharmaceutical formulations and formulations thus obtained | |
MX2017009660A (en) | Pharmaceutical composition with a range of ratio between tramadol chlorhydrate and etoricoxib for its administration for the treatment of pain. | |
WO2013054178A3 (en) | Extended release pharmaceutical compositions containing carmabazepine | |
MX2021003355A (en) | Pharmaceutical composition containing alkyl carbamoyl naphthalenyloxy octenoyl hydroxyamide phosphate, tartrate or combination thereof, and preparation method therefor. | |
RU2019122120A (en) | ORAL PREPARATION IBUPROFEN |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 16769040 Country of ref document: EP Kind code of ref document: A2 |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
122 | Ep: pct application non-entry in european phase |
Ref document number: 16769040 Country of ref document: EP Kind code of ref document: A2 |