WO2016147166A2 - Dispositif de vaccination de masse - Google Patents

Dispositif de vaccination de masse Download PDF

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Publication number
WO2016147166A2
WO2016147166A2 PCT/IB2016/052833 IB2016052833W WO2016147166A2 WO 2016147166 A2 WO2016147166 A2 WO 2016147166A2 IB 2016052833 W IB2016052833 W IB 2016052833W WO 2016147166 A2 WO2016147166 A2 WO 2016147166A2
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WO
WIPO (PCT)
Prior art keywords
needle
vaccine
cartridge
vaccination
unit
Prior art date
Application number
PCT/IB2016/052833
Other languages
English (en)
Other versions
WO2016147166A3 (fr
Original Assignee
Adst Technologies Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adst Technologies Ltd. filed Critical Adst Technologies Ltd.
Publication of WO2016147166A2 publication Critical patent/WO2016147166A2/fr
Publication of WO2016147166A3 publication Critical patent/WO2016147166A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205—Vaccinating by means of needles or other puncturing devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/08—Accessories or related features not otherwise provided for
    • A61B2090/0813—Accessories designed for easy sterilising, i.e. re-usable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2250/00—Specially adapted for animals

Definitions

  • the present invention in some embodiments thereof, relates to a mass vaccination device and, more particularly, but not exclusively, to a mass vaccination device for use on human beings.
  • Vaccination may be one of the most effective methods of preventing infectious diseases, with widespread immunity due to vaccination potentially responsible for the worldwide eradication of smallpox and the restriction of diseases such as polio, measles, and tetanus from much of the world.
  • Perhaps the most widely accepted reason for mass vaccination is to rapidly increase population immunity in the setting of an existing or potential outbreak, thereby limiting the morbidity and mortality that might result, especially when there has been no routine vaccination, or because populations have been displaced and routine immunization services disrupted.
  • a second important use of mass vaccination is to accelerate disease control to rapidly increase coverage with a new vaccine at the time of its introduction into routine immunization programs, and to attain large population immunity levels required to meet international targets for eradication and mortality reduction.
  • Mass immunization involves delivering immunizations to a large number of people at one or more locations in a short interval of time.
  • Good mass immunization programs apply planning and quality standards that maximize return on resources invested and provide the greatest individual benefits when immunizing many people in a short period of time. These programs can be used to counter contagious outbreaks, adopted as a repeated means of sustained healthcare delivery, or applied where many people move through a specific place in a short interval of time.
  • Mass vaccination devices are known in the art. Most of these devices which are used on humans are based on the use of the jet injector, which is a type of medical injecting syringe that uses a high-pressure narrow jet of the injection liquid instead of a hypodermic needle to penetrate the epidermis.
  • Needle-based mass vaccination devices are typically used for mass vaccination of animals.
  • US Patent No. 8,529,522 discloses "A fluid transfer device including a cartridge having a plurality of needles, an advancer operative to selectably advance any of the plurality of needles in the cartridge to a needle deployment position, and a syringe operative to convey fluid through the needle in the needle deployment position".
  • WO/2014/016807 discloses "A system for mass vaccinations including an electronic injector device having at least one needle for administering a measured amount of a vaccine; and an electronic fluid delivery device to deliver variable vaccine dosages to the injector device, and to deliver the measured amount of the vaccine".
  • a device for mass vaccinations of humans including a replaceable needle cartridge, a needle driving mechanism, and a vaccine container.
  • the replaceable cartridge includes a plurality of needle sleeves.
  • Each needle sleeve of said plurality of needle sleeves includes a needle, and a spring.
  • the needle driving mechanism includes a needle piston.
  • the device includes a fluid transfer tube for transferring a vaccine from the vaccine container to the needle driving mechanism.
  • the device includes a protection mechanism to prevent biological material contamination.
  • the device includes a flexible belt interconnecting the plurality of sleeves.
  • the device includes a cartridge drive unit.
  • the device includes a feeder tube.
  • the device includes a filter.
  • the device includes sterilization means for sterilizing needles.
  • the device includes a pump.
  • the replaceable needle cartridge and the needle driving mechanism are housed in an injector unit.
  • the injector unit is configured to be held with one hand.
  • the vaccine container is housed in a supply unit.
  • the supply unit is configured to be carried as a backpack.
  • the supply unit is configured to be carried as a belt bag.
  • Figure 1 is a functional block diagram of an exemplary mass vaccination device for use on human beings, according to an embodiment of the present invention
  • Figure 2A schematically illustrates an exemplary layout of the mass vaccination device, including an injector unit and a supply unit, according to an embodiment of the present invention
  • Figure 2B schematically illustrates an enlarged view of the injector unit, according to an embodiment of the present invention
  • FIGS. 3A - 3D schematically illustrate an exemplary needle cartridge for use with the injector unit, according to an embodiment of the present invention
  • FIGS. 4A - 4C schematically illustrate a cartridge drive unit for advancing needle sleeves inside the needle cartridge, according to an embodiment of the present invention
  • FIGS. 5A - 5C schematically illustrate an exemplary cartridge with a protection mechanism, according to an embodiment of the present invention
  • FIGS. 6A - 6C schematically illustrate an exemplary cartridge with a protection mechanism, according to some embodiments of the present invention
  • Figures 7A - 7C schematically illustrate exemplary cartridges with protection mechanisms, according to some embodiments of the present invention
  • Figures 8A and 8B schematically illustrate an exemplary injection unit including a cover to allow access to the replaceable needle piston and feeder tube, according to an embodiment of the present invention
  • Figures 9A and 9B schematically illustrate several exemplary portable transport configurations for the mass vaccination device, according to some embodiments of the present invention
  • Figure 10 is a flow diagram of an exemplary method of communicating with a health monitoring system including a database for vaccination data storage following use of the mass vaccination device, according to an embodiment of the present invention.
  • Figure 11 is a flow diagram of an exemplary method of post-vaccination patient identification following use of the mass vaccination device, according to an embodiment of the present invention.
  • An aspect of an embodiment of the present invention relates to a portable needle-based mass vaccination device which may be suitable for repeated intramuscular and subcutaneous administration of vaccinations and other fluids to a relatively large group of people.
  • the device may facilitate mass vaccinations by allowing each vaccination candidate to be injected using an unused needle which is automatically selected from a collection of multiple unused needles stored in the device.
  • the multiple needles may be stored in sleeves in a disposable cartridge which may be removably attached to the device.
  • the device may additionally facilitate mass vaccinations by preventing unwanted transfer of biological material (e.g. due to blood particles which may be spattered onto the device) between vaccination candidates, a problem which has limited the use of mass vaccination devices in the past, including jet injector vaccination devices.
  • the device may provide further protection to the vaccination candidates by sterilizing each unused needle prior to use. Additionally, the device may provide for even further protection by including a fluid transfer system which allows periodic replacement of tubing and other vaccine fluid transfer components through which the vaccine flows to the unused needle to prevent the development of bacterial growth which may reach the needle (and thereby the vaccination candidate). Applicant has realized that mass vaccination device as described above may be particularly advantageous compared to known vaccination devices as a large number of candidates may be quickly vaccinated with the same device substantially without incurring risk of cross-candidate infections while maintaining increased sterility.
  • Applicant has further realized that the use of replaceable components in the device, for example, a disposable needle cartridge, tubing and components in the fluid transfer system, and a vaccine container, allows a user of the device to readily switch between vaccines if required for administering different vaccines to different groups within a large number of candidates.
  • the mass vaccination device may be connected to computing devices, either through a direct interface or a server interface, to upload to the computing device's database information associated with a mass vaccination program. This information may then be available to health and other monitoring personnel as may be required.
  • the uploaded information may include the name and other identification information associated with a vaccination candidate, the type of vaccine and the amount of vaccine being administered, the date, time and location of where the vaccine is being administered, and inventory information such as for example the number of needles or the amount of vaccine portions remaining, among many other data which may be uploaded for control of the mass vaccination program.
  • connection to the computing devices may be to download data associated with the mass vaccination program, and which may include data which may serve to automatize the operation of the device, for example, to program the amount of a vaccine portion to be administered and which may include combining amounts of different vaccine serums to be administered as a single vaccine to a candidate.
  • the mass vaccination device may be used for DNA identification of candidates who have been vaccinated.
  • DNA samples may be obtained from each of the used needles in a removed cartridge and by cross- referencing the DNA samples with a needle identifier (for example, needle number and cartridge number) and other information uploaded to the database for each vaccinated candidate, it may be possible to identify whether or not a candidate has been vaccinated. Furthermore, it may also be possible to identify the candidate by comparing the DNA with existing information in DNA databases.
  • a needle identifier for example, needle number and cartridge number
  • the mass vaccination device may include a handheld unit which may be operated by a user with one hand.
  • the handheld unit may include the replaceable needle cartridge which may include a protection mechanism which may provide cross-user infection prevention and optionally needle sterilization.
  • the injector unit may additionally include a needle drive mechanism, which may also be replaceable, and which serves to propel the needles in the needle cartridge during a vaccination (injection) procedure.
  • the device may additionally include a supply unit which may be readily worn by the user and which may be used to store a vaccine container and components of the fluid transfer system which may serve to transfer the vaccine through a suitable fluid connection to the handheld device (e.g. pumps, filter, etc.).
  • the supply unit may also store electronics and other components associated with controlling the device as well as with powering the device.
  • the supply unit may be used as a wearable unit which may be fitted inside a backpack, a front pack, a waist bag, a shoulder bag, or other suitable bag or housing.
  • the mass vaccination device may be a single handheld unit integrating all the components of the device into the single unit, including components which would otherwise be included in the wearable unit.
  • the mass vaccination device may have two modes of operation, a preparation mode prior to initiating vaccinations and a vaccination mode.
  • the preparation mode the device may be programmed according to the vaccination program to be administered and may additionally be primed to clean the system and/or to remove any air or other contaminants from the fluid flow paths in the device.
  • the vaccination mode the device is prepared for vaccination and a user may vaccinate one candidate after another according to predetermined criteria associated with use of the device.
  • the predetermined criteria may be related to the number of vaccinations performed, the amount of vaccine serum left, the number of unused needles left, among many other possible criteria.
  • the mass vaccination device may be arranged as a kit, with some of the components suitable to be replaced by similar sterilized components after a predetermined number of vaccinations. This may allow for repeated use of the device without having to stop its operation for sterilization purposes, or otherwise preventing the need to dispose of the device after a number of repeated uses. This aspect may be potentially advantageous, particularly when mass vaccination may be required as a result of toxological and/or biological events, where many people may be affected over a very short period of time. This may be additionally potentially advantageous in field applications where sterilization facilities are not available and where relatively fast delivery of new sterilized devices may not be possible.
  • Figure 1 is a functional block diagram of an exemplary mass vaccination device 100 for use on human beings, according to an embodiment of the present invention.
  • Figure 2A schematically illustrates an exemplary layout of device 100, including an injector unit 101 and a supply unit 103
  • Figure 2B schematically illustrates an enlarged view of the injector unit, according to an embodiment of the present invention.
  • Injector unit 101 and supply unit 103 may be two physically separated units with the injector unit being a handheld unit and the supply unit being a wearable unit which may be worn or carried by an operator of the mass vaccination device.
  • injector unit 101 and supply unit 103 may be combined into one single unit, as indicated by hatched arrow 115 in Figure 2A.
  • Device 100 may include a vaccine container 102, a fluid transfer system 104, a needle driver 106, a needle cartridge 108, a needle drive mechanism 110, batteries 112, a charger unit 114, electronics/control unit 116, a safety catch mechanism 118, an operating switch 120, a security mechanism 122, a protection mechanism 124, and a cartridge drive unit 126.
  • Vaccine container 102, batteries 112, battery charger unit 114, and electronics and control unit 116 may be included in supply unit 103.
  • Needle driver 106, needle cartridge 108, needle drive mechanism 110, safety catch mechanism 118, operating switch 120, security mechanism 122, protection mechanism 124, and cartridge drive unit 126 may all be included in injection unit 101.
  • Fluid transfer system 104 may be distributed between injection unit 101 and supply unit 103, and may include an interconnecting tube 117 fluidly connecting components in injection unit 101 with components in supply unit 103, as described further on.
  • Vaccine container 102 may include one or more containers for holding a vaccine or a serum, or different vaccines or serums, which are to be administered to group of people using device 100.
  • Vaccine container may be any type of container known in the art and suitable for holding the vaccine or serum (for convenience hereinafter, uses of the term "the vaccine” or “vaccine” in its singular or plural form additionally refers to "serum” in its singular or plural form), optionally the amount in the container is equivalent or slightly greater than that to that to be injected by the needles stored in needle cartridge 108.
  • vaccine container 102 may hold 500 ml of vaccine, or slightly greater.
  • vaccine container 102 may hold more vaccine than the amount to be injected using a single cartridge 108, for example, sufficient for 2, 3, 4, or more cartridges, or may hold less so that that vaccine container may require replacement before all the needles in a cartridge are expended.
  • Fluid transfer system 104 may include a pump 104A, interconnecting tube
  • Pump 104A which may be located in supply unit 103, may be used to pump the vaccine from vaccine container 102 through interconnecting line 117 to injection unit 101.
  • Pump 104A may be any suitable type of pump capable of operating under the conditions to which mass vaccination device 100 may be subject, including capable of delivering the required amount of vaccine required for each injection, and capable of delivering a predetermined number of injections over a lifetime of the pump, for example, 1000 injections, 5000 injections, 10000 injections, 25000 injections, 50000 injections, 100000 injections, or more.
  • Pump 104A may additionally be capable of resisting contact with different types of vaccines which may be used from time to time in mass vaccination device 100 over the lifetime of the pump.
  • Examples of pumps which may be used for pump 104A may include, but not be limited to, a diaphragm pump and a peristaltic pump.
  • Filter 105 may be connected between vaccine container 102 and pump 104 to substantially prevent contaminants from the environment or from the vaccine container, or from other sources, from entering into the pump and interconnecting tube 117 from the side of supply unit 103. Alternatively, filter 105 may be placed between pump 104 A and interconnecting tube 117.
  • Filter 105 may include a hydrophilic filter, and may have a pore size in the range from 0.05 microns to 0.45 microns, or greater or smaller, for example, 0.2 microns.
  • Interconnecting tube 117 may connect at the supply unit side to pump 104 and on the injection unit side to injection unit coupler 117A, and may serve to transfer the vaccine from supply unit 103 to injection unit 101.
  • Injection unit coupler 117A may include a feeder tube 117B which is fluidly connected to interconnecting tube 117, a hydrophilic filter 117C which may be functionally similar to filter 105 and may act as a secondary filter to filter possible contaminants in the vaccine which may enter through the interconnecting tube or which were not completely filtered by filter 105.
  • Interconnecting tube 117 and feeder tube 117B may be a flexible tube, a rigid tube, or may combine sections of flexible tubing with sections of rigid tubing.
  • Injection unit coupler 117A including feeder tube 117B and filter 117C may be optionally replaceable, and may be replaced periodically to prevent bacterial development inside the device.
  • Feeder tube 117B may connect to needle driver 106, which may be also be optionally replaceable component which may fluidly connect between fluid transfer system 104 and an unused needle 108C in needle cartridge 108 to allow vaccine flow into the needle.
  • Needle driver 106 may be part of a needle drive mechanism and, in addition to transporting the vaccine into needle 108C, may impart a force on the needle to drive the needle into human tissue as part of the vaccination process (muscular or subcutaneous).
  • needle driver 106 may be periodically replaced to prevent bacterial development inside the device.
  • Figures 3A - 3D Shown schematically in Figures 3A - 3D is an exemplary needle cartridge 108, according to an embodiment of the present invention.
  • Figures 4A - 4C schematically illustrate cartridge drive unit 126 for advancing needle sleeves 108B inside needle cartridge 108, according to an embodiment of the present invention.
  • Needle cartridge 108 may be a replaceable, optionally dispensable container, and may include a housing 108A wherein may be stored a plurality of needle sleeves 108B, each storing a needle 108C.
  • Housing 108A may include an opening 125 through which needle 108C may extend outwards during an injection.
  • Each needle sleeve 108B may include a spring 108D which may act to retract needle 108C back into the sleeve following injection.
  • Each sleeve 108B may include a cover 108E on one end, as shown, and may include a second cover which may be pierced by needle 108C during an injection, the covers serving to seal the sleeve to maintain the sterility of the needle.
  • the plurality of sleeves 108B may be interconnected by a flexible belt 107 which may serve to transport the sleeves inside the cartridge.
  • Cartridge drive unit 126 may include means to move flexible belt 107 and may serve for transporting needle sleeves 108B inside needle cartridge 108.
  • Cartridge drive unit 126 may include a Geneva mechanism and may include a cartridge wheel 127 A, a motor 126 A, a drive wheel 126B including a drive pin 126C, and a belt wheel 126D.
  • Sleeves 108B may be transported inside the cartridge and for each vaccination, a sleeve containing an unused needle 108C is aligned with needle driver 106 and with opening 125. Following injection, the used needle is retrieved into its sleeve, and the needle sleeves in the cartridge moved so that a sleeve with a new unused needle replaces the position (aligned with the needle driver) previously occupied by the sleeve with the used needle.
  • Needle drive mechanism 110 may include needle driver 106 and a mechanism for propelling the needle driver forward and backwards. It may be may be an optionally replaceable mechanism which may propel forward driver 106 into needle 108C inside sleeve 108B for vaccination and may retrieve the needle following vaccination. Needle driver 106 may be fluidly connected in needle drive mechanism 110 to feeder tube 117B for transferring the vaccine received through interconnecting tube 117 to needle 108C.
  • battery 112 may be a rechargeable battery or a disposable battery; additionally or alternatively may be an AC connection to power the device with AC and/or a pneumatic connection to power the device using pneumatic (air or other fluid).
  • Charger unit 128 may be used in conjunction with battery 112 and may include connection means for battery use, AC use and/or pneumatic use; may be used for direct data upload/download with a computing device or to a communications port for data communications with a remote server over a wired or wireless connection or a combination of both.
  • Electronics/Control unit 116 may include a controller to manage all device operations, and may include other electronic circuitry as may be required for device operation, including communications with computing devices.
  • Safety catch 118 may include a mechanism to prevent inadvertent activation of operating switch 120. Operating switch 120 may include an activation mechanism to operate the device.
  • Security mechanism 122 may include a mechanism to prevent inadvertent operation of the device, and may include means to prevent a user from inadvertent stabbing by needle 108C, optionally including preventing inadvertent activation of the needle motor and/or cartridge motor (see m below).
  • connecting arrows which may represent power connections 128, control and communication connections 130, mechanical connections, and fluid transfer connections 134.
  • Protection mechanism 124 may include a mechanism to prevent cross- candidate infection and optionally may include a mechanism to sterilize each needle prior to injection.
  • Shown schematically in Figures 5A - 5C is an exemplary cartridge 208 with a protection mechanism 224, according to an embodiment of the present invention.
  • needle driver 106 before being propelled forward to drive needle 108C in sleeve 108B.
  • needle driver 106 pushing on sleeve 108B causing the sleeve to protrude out of the device and come into contact with the skin and acts as a protection mechanism.
  • Sleeve 108B circumferentially covers the area penetrated by needle 108C and prevents any biological material, for example blood, from splattering onto the device, with any splattered blood remaining within the sleeve which is retrieved together with the used needle and is replaced by a new sleeve with an unused needle for the next vaccination.
  • any biological material for example blood
  • Protection mechanism 324 may include a pad 133 of a sterilizing material is placed in front of the opening from which needle 108C will protrude during the vaccination sterilizing the unused needle (previously sterilized in factory). Pad 133 may be connected to rollers 131 and 131 A to allow moving the pad together with the sleeves so that a new area is always exposed to a new unused needle.
  • Figures 7A - 7C are exemplary cartridges 308, 308A, and 308B, with protection mechanisms 324, 324A, and 324B, respectively, according to some embodiments of the present invention.
  • opening 325 through which needle 108C protrudes during vaccination may be larger than the spattering area and may be larger than a diameter of sleeve 108B so that the sleeve is exposed and may receive all spattering; the spattered sleeve is replaced by a new sleeve with an unused needle for the next vaccination.
  • opening 325A through which needle 108C protrudes during vaccination may be larger than the spattering area and may be larger than a diameter of sleeve 108B so that the sleeve is exposed and may receive all spattering.
  • a distancing flange 325B may be placed around the opening from which needle 108B protrudes during vaccination and may be large enough so that the only exposed surface is that of needle sleeve 108B which may receive then receive all the spattering; the spattered sleeve is replaced by a new sleeve with an unused needle for the next vaccination.
  • FIG. 8A and 8B Shown schematically in Figures 8A and 8B is an exemplary injection unit 101 including a cover 137 to allow access to the replaceable needle piston 106 and feeder tube 117B, according to an embodiment of the present invention.
  • Replacement of both needle piston 106 and feeder tube 117B may be periodically done to prevent bacterial development inside the device.
  • replacement of the interconnecting tube 117 may also be done periodically with the feeder tube.
  • filter 117C see Figure 2B).
  • FIGS 9A and 9B Shown schematically in Figures 9A and 9B are several exemplary portable transport configurations for the mass vaccination device 100, according to some embodiments of the present invention.
  • all the components of mass vaccination device 100 are integrated into a single unit, which may be handheld by the user.
  • injection unit 101 is a single handheld unit which may be connected through interconnecting tube 117 to any one of a belt pouch 103A, a backpack 103B, or a front pack 103C, according to different possible device configurations.
  • Mass vaccination device 100 may be connected to computing devices, either through a direct interface or a server interface, to upload to the computing device's database information associated with a mass vaccination program. This information may then be available to health and other monitoring personnel as may be required.
  • the uploaded information may include the name and other identification information associated with a vaccination candidate, the type of vaccine and the amount of vaccine being administered, the date, time and location of where the vaccine is being administered, and inventory information such as for example the number of needles or the amount of vaccine portions remaining, among many other data which may be uploaded for control of the mass vaccination program.
  • connection to the computing devices may be to download data associated with the mass vaccination program, and which may include data which may serve to automatize the operation of the device, for example, to program the amount of a vaccine portion to be administered and which may include combining amounts of different vaccine serums to be administered as a single vaccine to a candidate.
  • mass vaccination device 100 may be used for DNA identification of candidates who have been vaccinated.
  • DNA samples may be obtained from each of the used needles in a removed cartridge and by cross-referencing the DNA samples with a needle identifier (for example, needle number and cartridge number) and other information uploaded to the database for each vaccinated candidate, it may be possible to identify whether or not a candidate has been vaccinated. Furthermore, it may also be possible to identify the candidate by comparing the DNA with existing information in DNA databases.
  • a needle identifier for example, needle number and cartridge number
  • this feature may be particularly useful when positive identification of a vaccination candidate is not possible, for example, during natural disasters, wars, and other types of disasters were many people may suffer injuries or may be infected by biological or toxological agents and mass vaccinations may be required, yet the candidates may not be readily identifiable.
  • Embodiments of the present invention may include apparatus for performing the operations herein.
  • This apparatus may be specially constructed for the desired purposes, or it may comprise a general-purpose computer selectively activated or reconfigured by a computer program stored in the computer.
  • a computer program may be stored in a computer readable storage medium, such as, but not limited to, any type of disk, including floppy disks, optical disks, magnetic -optical disks, read-only memories (ROMs), compact disc read-only memories (CD-ROMs), random access memories (RAMs), electrically programmable read-only memories (EPROMs), electrically erasable and programmable read only memories (EEPROMs), magnetic or optical cards, Flash memory, or any other type of media suitable for storing electronic instructions and capable of being coupled to a computer system bus.
  • ROMs read-only memories
  • CD-ROMs compact disc read-only memories
  • RAMs random access memories
  • EPROMs electrically programmable read-only memories
  • EEPROMs electrically erasable and

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Engineering & Computer Science (AREA)
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Abstract

L'invention concerne un dispositif pour des vaccinations de masse d'êtres humains. Le dispositif comprend une cartouche d'aiguilles remplaçable, un mécanisme d'entraînement d'aiguille, et un contenant de vaccin.
PCT/IB2016/052833 2015-03-14 2016-05-16 Dispositif de vaccination de masse WO2016147166A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562133293P 2015-03-14 2015-03-14
US62/133,293 2015-03-14

Publications (2)

Publication Number Publication Date
WO2016147166A2 true WO2016147166A2 (fr) 2016-09-22
WO2016147166A3 WO2016147166A3 (fr) 2016-11-24

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3545988A1 (fr) * 2018-03-29 2019-10-02 Tecpharma Licensing AG Dispositif de dosage comprenant un dispositif de réglage pour un injecteur

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7392638B2 (en) * 2000-08-10 2008-07-01 Baxa Corporation Method, system, and apparatus for handling, labeling, filling, and capping syringes with improved cap
ATE460192T1 (de) * 2003-06-17 2010-03-15 Adst Technologies Ltd Fluidtransfer-vorrichtung mit entfernbarer nadelkartusche
US20070185437A1 (en) * 2006-02-03 2007-08-09 Boris Goldenberg Needle-free syringe and the injection procedure
CA2688088A1 (fr) * 2007-03-06 2008-09-12 Adst Technologies Ltd. Dispositif d'injection rapide
BR112015001559A2 (pt) * 2012-07-26 2017-07-04 Syrinjector Ltd método e sistema para vacinações em massa
US20140039237A1 (en) * 2012-08-06 2014-02-06 Ming-Hsin Li Medication dispensing device

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3545988A1 (fr) * 2018-03-29 2019-10-02 Tecpharma Licensing AG Dispositif de dosage comprenant un dispositif de réglage pour un injecteur
WO2019186378A1 (fr) * 2018-03-29 2019-10-03 Tecpharma Licensing Ag Dispositif de dosage avec dispositif d'actionnement pour stylo injecteur

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