WO2016107949A1 - System for quantifying blood glucose levels - Google Patents

System for quantifying blood glucose levels Download PDF

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Publication number
WO2016107949A1
WO2016107949A1 PCT/ES2015/070953 ES2015070953W WO2016107949A1 WO 2016107949 A1 WO2016107949 A1 WO 2016107949A1 ES 2015070953 W ES2015070953 W ES 2015070953W WO 2016107949 A1 WO2016107949 A1 WO 2016107949A1
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WO
WIPO (PCT)
Prior art keywords
blood
blood glucose
glucose levels
quantifying
tongue
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Application number
PCT/ES2015/070953
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Spanish (es)
French (fr)
Inventor
Joaquin BUSTELO DE LA QUINTANA
Original Assignee
Dispositivos No Invasivos Para Diagnosis, S.L.
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Application filed by Dispositivos No Invasivos Para Diagnosis, S.L. filed Critical Dispositivos No Invasivos Para Diagnosis, S.L.
Publication of WO2016107949A1 publication Critical patent/WO2016107949A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters

Definitions

  • the present invention relates to a system of quantification of blood glucose levels, a system that is embodied in a portable device of small size and economical in its manufacture, which allows quantifying blood glucose levels by non-invasive methods, with interaction of eating habits and their corresponding telematic referral to a database of data processing, reserved and personalized in the specialty of diabetes.
  • the object of the invention is specifically to measure glycemia in people and to be able to send these data in real time to a medical center for the control and monitoring of the patient and achieve a blood glucose curve.
  • blood glucose is drawn from a vein, or by puncturing the fingertips to get a drop of blood, depositing it in a test strip where blood glucose is measured.
  • the procedure involves a device based on an ultraviolet light source that releases its radiation through a diffraction grating, filtering through slit filters already mentioned, directing them to photosensors that conform and compare them with known parameters in a shaper of signal being subsequently decoded and then calibrated under normal conditions to pass to a parameter selector and a level evaluator in final signal that is encoded to present on a visual screen, establishing an evaluation by electronic means.
  • the light source is a lamp connected to the network, with the removal of the tissue by transillumination, obtaining the spectrum by transparency of the illuminated skin.
  • the light bulb has no intensity control and no touch screen is included to show blood glucose values.
  • Another characteristic of novelty is that it incorporates a specific software to quantify glycemia, lighting in the tongue is made by reflection, through optical fibers through which the focus of led light is applied, on the patient's tongue, including also a second inclined optical fiber for the collection of the reflected light corresponding to the led light bulb.
  • Another characteristic of novelty presented by the system of the invention is that it includes an optical translator of the intensity of the monochromatic light corresponding to the reflected light, the signal being accessed by that optics and subsequently passing to a processing medium, by microprocessor.
  • system of the invention includes a screen in which the value of the blood glucose obtained is displayed, as well as a touch screen with icons and means for sending data corresponding to a central medical control, which is known as telemedicine.
  • the system can incorporate a mobile phone.
  • glycemia can be measured in people, non-invasively, resulting in the device as a whole, economical, without connection to the electricity grid, allowing to take all the measures that are desired to achieve a daily glycemic curve along with all the complementary data such as lifestyle, activities, food, medication, etc., and all this allowing immediate shipment to a central medical control, being able to have an online conversation to correct the patient's pathological deviations, advising the necessary medication in a personalized way.
  • the system of the invention is based on using a led light bulb (1) with an intensity regulator (2) and a rechargeable battery (3) for powering it, so that through fiber optic (4) that light bulb is applied to the patient's tongue (5), while a second block of optical fibers (4 ') collects the light reflected in the tongue (5) and the it passes through an optical (6) with linear CCD, carrying out then a data processing by means of a microprocessor (7) to which a touch screen with icons (8) is connected and from which the corresponding value is obtained of the resulting glycemia (9), also including a screen (10) in which the value of the glycemia itself is signaled so that the data obtained can be sent through the corresponding means (1 1), to a control center doctor, being able to complement the system with a mobile phone (12), block (1 1) being the one that corresponds to sending data to the corresponding medical control center.
  • This system will include specific software to allow the entire process to be carried out.

Abstract

The system is used to measure glycemia in people and is based on the emission of an LED light applied to the tongue (5) of the patient, via an optical fibre (4), such that the light reflected on said tongue (5) and through a second group of optical fibres (4') is sent to an optical element with CCD (6) for further processing by a microprocessor (7), from which the glycemia values (9) are obtained, said values being displayed on a screen (10), in association with a tactile screen with icons (8), so that the resulting data can be sent to a medical control centre (11), all while being able to be connected to a mobile telephone (12).

Description

SISTEMA DE CUANTIFICACION DE LOS NIVELES DE GLUCOSA EN SANGRE.  QUANTIFICATION SYSTEM OF GLUCOSE LEVELS IN BLOOD.
D E S C R I P C I Ó N D E S C R I P C I Ó N
OBJETO DE LA INVENCIÓN OBJECT OF THE INVENTION
La presente invención se refiere a un sistema de cuantificación de los niveles de glucosa en sangre, sistema que se materializa en un dispositivo portátil de reducido tamaño y económico en su fabricación, que permite cuantificar los niveles de glucosa en sangre por métodos no invasivos, con interacción de hábitos alimenticios y su correspondiente remisión telemática a una base de tratamiento de datos, reservada y personalizada en la especialidad de diabetes. The present invention relates to a system of quantification of blood glucose levels, a system that is embodied in a portable device of small size and economical in its manufacture, which allows quantifying blood glucose levels by non-invasive methods, with interaction of eating habits and their corresponding telematic referral to a database of data processing, reserved and personalized in the specialty of diabetes.
El objeto de la invención es medir concretamente la glucemia en personas y poder enviar en tiempo real esos datos a un centro médico para el control y seguimiento del paciente y conseguir una curva de glucemia. The object of the invention is specifically to measure glycemia in people and to be able to send these data in real time to a medical center for the control and monitoring of the patient and achieve a blood glucose curve.
ANTECEDENTES DE LA INVENCIÓN BACKGROUND OF THE INVENTION
Actualmente, para medir la glucemia se lleva a cabo una extracción de sangre de una vena, o bien realizando una punción en la yema de los dedos para conseguir una gota de sangre, depositándose esta en una tirita reactiva donde se mide la glucemia. Currently, to measure blood glucose, blood is drawn from a vein, or by puncturing the fingertips to get a drop of blood, depositing it in a test strip where blood glucose is measured.
Estos métodos dan una medida en un momento concreto, pero no son ideales para valorar la diabetes, ya que tendría que hacerse una curva de glucemia a base de tomar muestras de sangre cada veinte minutos, (muchas veces al día), lo cual es incomodo y doloroso, sobre todo para los niños, debido al endurecimiento de la piel de la yema de los dedos por culpa de las punciones, además que en la práctica no se puede desarrollar todos los días. These methods give a measure at a specific time, but they are not ideal for assessing diabetes, since a blood glucose curve should be done based on taking blood samples every twenty minutes, (many times a day), which is uncomfortable and painful, especially for children, due to the hardening of the skin of the fingertips because of the punctures, in addition that in practice it cannot develop every day.
Además, si surgen complicaciones en el caso de aparecer una alteración cuantitativa del valor de la glucemia, obligaría a pedir cita en el ambulatorio, con la demora correspondiente. Por otro lado, independientemente de la frecuencia de toma de sangre, hay que tener en cuenta la correlación de los valores de la curva de glucemia con el modo de vida, la actividad que se esta desarrollando, la alimentación, la medicación, etc, para poder fijar exactamente el tratamiento-pronóstico. In addition, if complications arise in the case of a quantitative alteration of the glycemic value, it would require an appointment in the outpatient clinic, with the corresponding delay. On the other hand, regardless of the frequency of blood collection, it should be taken into It counts the correlation of the values of the glycemic curve with the way of life, the activity that is being developed, the feeding, the medication, etc., in order to be able to fix exactly the prognosis-treatment.
La problemática anteriormente expuesta se resuelve con el procedimiento y dispositivo reivindicado en la patente de invención 512366, actualmente de dominio público y cuyo inventor es el mismo que el de la presente solicitud, de manera que en esa patente de invención se escribe un procedimiento y dispositivo para realizar un análisis simultáneo de los niveles, en sangre, de colesterol, ácido úrico y glucosa, conjunta o aisladamente, de manera que el procedimiento se basa en hacer pasar una radiación ultravioleta por un retículo que la difracta en un haz, de acuerdo con las longitudes de onda que serán absorbidas en mayor o menor grado según los factores de absorción característicos de las sustancias por las que atraviesa, de manera que esa radiación convenientemente modificada es seleccionada mediante filtros y a continuación de ellos la disposición de unos fotosensores, paralelamente amplificadas las señales, comparadas con parámetros de muestra, siendo a continuación decodificadas sumando y restado los valores absolutos obtenidos con el fin de obtener el nivel relativo a las sustancias analizadas, consiguiendo tres variables desconocidas a partir de otras tres dadas, que amplificadas y calibradas darán unos valores de muestra conocidos, pudiéndose seleccionar el parámetro teniendo una apreciación secuencial de los análisis o no seleccionarla para una lectura simultánea de resultados, que serán materializados tras su detección, así como evaluados u codificados para su uso y entendimiento. The aforementioned problem is solved with the procedure and device claimed in the invention patent 512366, currently in the public domain and whose inventor is the same as that of the present application, so that in that invention patent a procedure and device is written to perform a simultaneous analysis of the levels, in blood, of cholesterol, uric acid and glucose, jointly or in isolation, so that the procedure is based on passing ultraviolet radiation through a reticulum that diffracts it in a beam, according to the wavelengths that will be absorbed to a greater or lesser degree according to the characteristic absorption factors of the substances through which it passes, so that this radiation conveniently modified is selected by filters and following them the arrangement of photosensors, parallel amplified the signals, compared with sample parameters, being then Decoded by adding and subtracting the absolute values obtained in order to obtain the level relative to the analyzed substances, obtaining three unknown variables from three other given ones, which amplified and calibrated will give known sample values, being able to select the parameter having a Sequential assessment of the analysis or not selecting it for simultaneous reading of results, which will be materialized after detection, as well as evaluated or coded for use and understanding.
En el procedimiento participa un dispositivo basado en una fuente de luz ultravioleta que lanza su radiación a través de un retículo de difracción, filtrándose a través de filtros de rendija ya comentados, dirigiéndolos a fotosensores que los conforma y compara con parámetros conocidos en un conformador de señal siendo posteriormente descodificados y seguidamente calibrados en condiciones normales para pasar a un selector de parámetro y a un evaluador de nivel en señal final que es codificada para presentar en pantalla visual, estableciéndose una evaluación mediante electrónica. The procedure involves a device based on an ultraviolet light source that releases its radiation through a diffraction grating, filtering through slit filters already mentioned, directing them to photosensors that conform and compare them with known parameters in a shaper of signal being subsequently decoded and then calibrated under normal conditions to pass to a parameter selector and a level evaluator in final signal that is encoded to present on a visual screen, establishing an evaluation by electronic means.
Entre los inconvenientes que presenta el procedimiento y dispositivo descrito en esa patente de invención anterior 512366, actualmente de dominio público, pueden citarse como mas importantes los siguientes: Es un dispositivo de elevado coste, con posibilidades muy limitadas y con poco control del paciente, en este caso del diabético, incorporando un software sencillo. Among the drawbacks of the procedure and device described in that prior invention patent 512366, currently in the public domain, the following may be mentioned as more important: It is a device of high cost, with very limited possibilities and with little control of the patient, in this case of the diabetic, incorporating simple software.
Otro inconveniente es que el foco de luz es una lámpara conectada a red, realizándose la eliminación del tejido por transiluminación, obteniéndose el espectro por transparencia de la piel iluminada. Another drawback is that the light source is a lamp connected to the network, with the removal of the tissue by transillumination, obtaining the spectrum by transparency of the illuminated skin.
El foco de luz no tiene ningún control de intensidad y no se incluye pantalla táctil para mostrar los valores de la glucemia. The light bulb has no intensity control and no touch screen is included to show blood glucose values.
DESCRIPCIÓN DE LA INVENCIÓN DESCRIPTION OF THE INVENTION
Los problemas e inconvenientes anteriormente referidos, quedan solventados con el sistema objeto de la invención, basándose éste en utilizar como foco de luz un foco led que incorpora el propio dispositivo en el que se materializa el sistema y además ese foco de luz es alimentado por batería recargable. The aforementioned problems and disadvantages are solved with the system object of the invention, this being based on using as a light bulb a led bulb that incorporates the device itself in which the system materializes and also that light bulb is powered by battery rechargeable
Otra característica de novedad es que incorpora un software especifico para cuantificar la glucemia, efectuándose una iluminación en la lengua por reflexión, a través de unas fibras ópticas a través de las cuales se aplica el foco de luz led, sobre la lengua del paciente, incluyendo además una segunda fibra óptica inclinada para la recogida de la luz reflejada correspondiente al foco de luz led. Another characteristic of novelty is that it incorporates a specific software to quantify glycemia, lighting in the tongue is made by reflection, through optical fibers through which the focus of led light is applied, on the patient's tongue, including also a second inclined optical fiber for the collection of the reflected light corresponding to the led light bulb.
Otra característica de novedad que presenta el sistema de la invención es que se incluye una óptica traductor de la intensidad de la luz monocromática correspondiente a la luz reflejada, accediendo la señal a esa óptica y haciendo pasar posteriormente a un medio de procesamiento, mediante microprocesador. Another characteristic of novelty presented by the system of the invention is that it includes an optical translator of the intensity of the monochromatic light corresponding to the reflected light, the signal being accessed by that optics and subsequently passing to a processing medium, by microprocessor.
Además, el sistema de la invención, incluye una pantalla en que se visualiza el valor de la glucemia obtenida, así como una pantalla táctil con iconos y medios para el envío de datos correspondientes a una central de control médico, lo que se conoce con la denominación de telemedicina. In addition, the system of the invention includes a screen in which the value of the blood glucose obtained is displayed, as well as a touch screen with icons and means for sending data corresponding to a central medical control, which is known as telemedicine.
Opcionalmente el sistema puede incorporar un teléfono móvil. Optionally the system can incorporate a mobile phone.
Mediante este sistema o dispositivo en que se materializa el mismo, se puede medir la glucemia en personas, de forma no invasiva, resultando el dispositivo en su conjunto portátil, económico, sin conexión a la red eléctrica, permitiendo tomar todas las medidas que se deseen para conseguir una curva de glucemia diaria junto con todos los datos complementarios tales como modo de vida, actividades, alimentación, medicación, etc, y todo ello permitiendo su envío inmediato a una central de control medica, pudiendo tener una conversación "on line" para corregir las desviaciones patológicas del paciente, aconsejando la medicación necesaria de forma personalizada. Through this system or device in which it is materialized, glycemia can be measured in people, non-invasively, resulting in the device as a whole, economical, without connection to the electricity grid, allowing to take all the measures that are desired to achieve a daily glycemic curve along with all the complementary data such as lifestyle, activities, food, medication, etc., and all this allowing immediate shipment to a central medical control, being able to have an online conversation to correct the patient's pathological deviations, advising the necessary medication in a personalized way.
También cabe destacar el hecho de que con el sistema de la invención, y en base a la técnica en que se basa el mismo, pueden cuantificarse otras sustancias tales como carotinoides, crolipoide, melaninas y porfilinas. Also noteworthy is the fact that with the system of the invention, and based on the technique on which it is based, other substances such as carotinoids, crolipoid, melanins and porphillins can be quantified.
DESCRIPCIÓN DE LOS DIBUJOS DESCRIPTION OF THE DRAWINGS
Para complementar la descripción que seguidamente se va a realizar y con objeto de ayudar a una mejor comprensión de las características del invento, de acuerdo con un ejemplo preferente de realización práctica del mismo, se acompaña como parte integrante de dicha descripción, una hoja única de planos en donde con carácter ilustrativo y no limitativo, se ha representado lo siguiente: To complement the description that will then be made and in order to help a better understanding of the characteristics of the invention, in accordance with a preferred example of practical implementation thereof, a single sheet of said description is attached as an integral part of said description. planes where, for illustrative and non-limiting purposes, the following has been represented:
La figura única mostrada en la hoja de planos corresponde a un diagrama de bloques en que se materializa el sistema. REALIZACIÓN PREFERENTE DE LA INVENCIÓN The unique figure shown on the plan sheet corresponds to a block diagram in which the system materializes. PREFERRED EMBODIMENT OF THE INVENTION
Como se puede ver en la figura referida, el sistema de la invención se basa en utilizar un foco de luz led (1 ) con un regulador (2) de intensidad y una batería recargable (3) para la alimentación del mismo, de manera que a través de fibra óptica (4) ese foco de luz se aplica sobre la lengua (5) del paciente, a la vez de que un segundo bloque de fibras ópticas (4') recoge la luz reflejada en la lengua (5) y la hace pasar a través de una óptica (6) con CCD lineal, llevándose a efecto a continuación un procesamiento de los datos mediante un microprocesador (7) al que esta conectada una pantalla táctil con iconos (8) y del que se obtiene el correspondiente valor de la glucemia (9) resultante, incluyendo también una pantalla (10) en la que se señaliza el valor de la glucemia propiamente dicha para que los datos obtenidos puedan ser enviados a través del correspondiente medio (1 1 ), a una central de control médico, pudiéndose complementar el sistema con un teléfono móvil (12), siendo el bloque (1 1 ) el que corresponde el envío de datos a la central de control médico correspondiente. As can be seen in the aforementioned figure, the system of the invention is based on using a led light bulb (1) with an intensity regulator (2) and a rechargeable battery (3) for powering it, so that through fiber optic (4) that light bulb is applied to the patient's tongue (5), while a second block of optical fibers (4 ') collects the light reflected in the tongue (5) and the it passes through an optical (6) with linear CCD, carrying out then a data processing by means of a microprocessor (7) to which a touch screen with icons (8) is connected and from which the corresponding value is obtained of the resulting glycemia (9), also including a screen (10) in which the value of the glycemia itself is signaled so that the data obtained can be sent through the corresponding means (1 1), to a control center doctor, being able to complement the system with a mobile phone (12), block (1 1) being the one that corresponds to sending data to the corresponding medical control center.
Este sistema incluirá un software especifico para permitir llevar a cabo todo el proceso. This system will include specific software to allow the entire process to be carried out.

Claims

R E I V I N D I C A C I O N E S R E I V I N D I C A C I O N E S
1 a.- Sistema de cuantificación de los niveles de glucosa en sangre, previsto concretamente para medir la glucemia en personas o pacientes, caracterizado porque comprende un foco de luz led (1 ), que a través de una fibra óptica (4) se hace incidir sobre la lengua (5) del paciente, incluyendo una segunda fibra óptica (4') para recogida de la luz reflejada en esa lengua (5) procedente del foco de luz led (1 ), habiéndose previsto una óptica con CCD (6) a través del cual se hace pasar la señal de la luz reflejada para su posterior procesamiento mediante un microprocesador (7), al que está asociada una pantalla de señalización del valor de la glucemia (9) obtenida, y una pantalla (8), táctil con iconos, todo ello en orden a que los datos resultantes, a través de un medio apropiado, se envíen a una central de control médico (1 1 ). 1 .- System quantifying glucose levels in blood, intended specifically to measure blood glucose in people or patients, characterized by comprising a light source LED (1), through an optical fiber (4) is made influence the patient's tongue (5), including a second fiber optic (4 ') to collect the light reflected in that tongue (5) from the led light bulb (1), with an optics provided with CCD (6) through which the reflected light signal is passed for further processing by means of a microprocessor (7), to which a blood glucose value signaling screen (9) obtained is associated, and a touch screen (8) with icons, all in order that the resulting data, through an appropriate means, be sent to a central medical control (1 1).
2a Sistema de cuantificación de los niveles de glucosa en sangre, según reivindicación 1 a, caracterizado porque el foco de luz led (1 ) está asociado a un regulador (2) de la intensidad de luz. System 2 to quantization levels in blood glucose according to claim 1, wherein the LED light source (1) is associated with a regulator (2) of the light intensity.
3a.- Sistema de cuantificación de los niveles de glucosa en sangre, según reivindicaciones 1 a y 2a, caracterizado porque el foco de luz led (1 ) es alimentado energéticamente mediante una batería recargable (3). 3 .- System quantifying glucose levels in the blood, according to claims 1 and 2, characterized in that the LED light bulb (1) is powered by a rechargeable battery energy (3).
4a.- Sistema de cuantificación de los niveles de glucosa en sangre, según reivindicaciones anteriores, caracterizado porque opcionalmente incorpora un teléfono móvil (12). 4 .- System quantifying glucose levels in the blood, according to previous claims, characterized in that optionally incorporates a mobile phone (12).
5a.- Sistema de cuantificación de los niveles de glucosa en sangre, según reivindicaciones anteriores, caracterizado porque permite tomar medidas cuantas veces se desee para conseguir una curva de glucemia. 5 .- System quantifying glucose levels in the blood, according to previous claims, characterized in that enables measurements as often as desired to achieve a blood glucose curve.
6a.- Sistema de cuantificación de los niveles de glucosa en sangre, según reivindicaciones anteriores, caracterizado porque incorpora un software especifico para cuantificar la glucemia. 6 a. - System for quantification of blood glucose levels, according to previous claims, characterized in that it incorporates a specific software for quantifying blood glucose.
PCT/ES2015/070953 2014-12-29 2015-12-28 System for quantifying blood glucose levels WO2016107949A1 (en)

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060276713A1 (en) * 2005-06-07 2006-12-07 Chemimage Corporation Invasive chemometry
DE102007015172A1 (en) * 2006-04-12 2007-10-25 Weinmann Geräte für Medizin GmbH & Co. KG Body fluid content e.g. glucose, determining method, involves directing radiation having equal wavelengths from two radiation sources simultaneously to body tissue for time period for penetration and/or reflection
US20100105996A1 (en) * 2008-10-29 2010-04-29 Cnoga Medical Ltd. Finger deployed device for measuring blood and physiological characteristics
CN201564481U (en) * 2009-12-31 2010-09-01 重庆大学 Non-invasive blood glucose monitoring analyzer
US20110028806A1 (en) * 2009-07-29 2011-02-03 Sean Merritt Reflectance calibration of fluorescence-based glucose measurements
CN103989483A (en) * 2014-05-28 2014-08-20 张一熙 Non-intrusive laser blood glucose painless detection carrying system

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060276713A1 (en) * 2005-06-07 2006-12-07 Chemimage Corporation Invasive chemometry
DE102007015172A1 (en) * 2006-04-12 2007-10-25 Weinmann Geräte für Medizin GmbH & Co. KG Body fluid content e.g. glucose, determining method, involves directing radiation having equal wavelengths from two radiation sources simultaneously to body tissue for time period for penetration and/or reflection
US20100105996A1 (en) * 2008-10-29 2010-04-29 Cnoga Medical Ltd. Finger deployed device for measuring blood and physiological characteristics
US20110028806A1 (en) * 2009-07-29 2011-02-03 Sean Merritt Reflectance calibration of fluorescence-based glucose measurements
CN201564481U (en) * 2009-12-31 2010-09-01 重庆大学 Non-invasive blood glucose monitoring analyzer
CN103989483A (en) * 2014-05-28 2014-08-20 张一熙 Non-intrusive laser blood glucose painless detection carrying system

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ES2537051A1 (en) 2015-06-01

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