WO2016076573A3 - 블로난세린의 제조방법 및 그를 위한 중간체 - Google Patents

블로난세린의 제조방법 및 그를 위한 중간체 Download PDF

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Publication number
WO2016076573A3
WO2016076573A3 PCT/KR2015/011788 KR2015011788W WO2016076573A3 WO 2016076573 A3 WO2016076573 A3 WO 2016076573A3 KR 2015011788 W KR2015011788 W KR 2015011788W WO 2016076573 A3 WO2016076573 A3 WO 2016076573A3
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WO
WIPO (PCT)
Prior art keywords
blonanserin
intermediate therefor
preparing
preparing blonanserin
therefor
Prior art date
Application number
PCT/KR2015/011788
Other languages
English (en)
French (fr)
Other versions
WO2016076573A2 (ko
Inventor
이경진
윤은영
Original Assignee
연성정밀화학(주)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 연성정밀화학(주) filed Critical 연성정밀화학(주)
Publication of WO2016076573A2 publication Critical patent/WO2016076573A2/ko
Publication of WO2016076573A3 publication Critical patent/WO2016076573A3/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

본 발명은 고순도 블로난세린을 온화한 반응 조건에서 고수율로 제조하는 방법 및 그에 사용되는 중간체에 관한 것이다.
PCT/KR2015/011788 2014-11-11 2015-11-04 블로난세린의 제조방법 및 그를 위한 중간체 WO2016076573A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2014-0156393 2014-11-11
KR1020140156393A KR20160056230A (ko) 2014-11-11 2014-11-11 블로난세린의 제조방법 및 그를 위한 중간체

Publications (2)

Publication Number Publication Date
WO2016076573A2 WO2016076573A2 (ko) 2016-05-19
WO2016076573A3 true WO2016076573A3 (ko) 2016-09-15

Family

ID=55955222

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2015/011788 WO2016076573A2 (ko) 2014-11-11 2015-11-04 블로난세린의 제조방법 및 그를 위한 중간체

Country Status (2)

Country Link
KR (1) KR20160056230A (ko)
WO (1) WO2016076573A2 (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT201600092469A1 (it) * 2016-09-14 2018-03-14 Lundbeck Pharmaceuticals Italy S P A Processo per la produzione di Blonanserina
CN110526867B (zh) * 2018-05-25 2021-12-03 湖南省湘中制药有限公司 一种高效制备布南色林中间体的方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101747273A (zh) * 2008-12-02 2010-06-23 浙江华海药业股份有限公司 布南色林中间体的制备方法
CN102030707A (zh) * 2010-11-12 2011-04-27 深圳万和制药有限公司 布南色林中间体的制备方法
CN102093289A (zh) * 2010-10-29 2011-06-15 常州华生制药有限公司 布南色林中间体的制备新方法
CN102887856A (zh) * 2012-10-17 2013-01-23 河北师范大学 一种合成布南色林的方法
JP2013216655A (ja) * 2012-04-09 2013-10-24 Mylan Laboratories Ltd ブロナンセリンの改善された調製方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101747273A (zh) * 2008-12-02 2010-06-23 浙江华海药业股份有限公司 布南色林中间体的制备方法
CN102093289A (zh) * 2010-10-29 2011-06-15 常州华生制药有限公司 布南色林中间体的制备新方法
CN102030707A (zh) * 2010-11-12 2011-04-27 深圳万和制药有限公司 布南色林中间体的制备方法
JP2013216655A (ja) * 2012-04-09 2013-10-24 Mylan Laboratories Ltd ブロナンセリンの改善された調製方法
CN102887856A (zh) * 2012-10-17 2013-01-23 河北师范大学 一种合成布南色林的方法

Also Published As

Publication number Publication date
WO2016076573A2 (ko) 2016-05-19
KR20160056230A (ko) 2016-05-19

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