WO2016070632A1 - Insect-killing mite-killing agent composition with synergistic effect - Google Patents
Insect-killing mite-killing agent composition with synergistic effect Download PDFInfo
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- WO2016070632A1 WO2016070632A1 PCT/CN2015/081926 CN2015081926W WO2016070632A1 WO 2016070632 A1 WO2016070632 A1 WO 2016070632A1 CN 2015081926 W CN2015081926 W CN 2015081926W WO 2016070632 A1 WO2016070632 A1 WO 2016070632A1
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- the present invention relates to an insecticidal and acaricidal composition having improved properties, and more particularly to an insecticidal and acaricidal composition comprising flumethrin and bifenthrin, and belongs to the field of pesticide preparations.
- Acerithrin is a high-efficiency, low-toxic, broad-spectrum, novel pyrethroid-killing insecticide and insecticide. It has good activity against a variety of food-borne pests, and also has good activity against pests and lepidopteran pests such as hibiscus, leaf miner, thrips and aphids. Used in crops such as cotton, fruit trees, soybeans, corn, vegetables, tea, grapes, citrus, and tobacco.
- Bifenthrin is a highly effective pyrethroid insecticide and acaricide. It has contact, stomach toxicity, no systemic and fumigation effects. It has a wide spectrum of insecticides and good control effect against cockroaches. Act quickly. It does not move in the soil, it is safer for the environment, and the residual effect period is long.
- the purpose of the invention is to screen the two insecticidal and acaricidal agents with different action principles for the resistance problem of the insecticide and acaricide in the practical application, so as to improve the effect of prevention and treatment, reduce the application amount and expand the use. range.
- the present invention provides a group of insecticidal and acaricidal compositions comprising two active ingredients A and B, active ingredient A being flumethrin and active ingredient B being bifenthrin.
- the inventors found through experiments that the above-mentioned insecticidal composition has obvious synergistic effect, and the application amount is reduced, which can reduce the use cost.
- the compounds containing component A and component B have different structural types and different mechanisms of action. The combination of the two can broaden the spectrum of action and can delay the generation of insect resistance to a certain extent, and component A and component B There is no cross-resistance.
- the present invention provides a preparation method comprising the two active ingredients A and B compositions and an application for controlling crop pests in the agricultural field.
- the composition comprises two active components A and B, and the weight ratio between the two components is 1:30 to 30:1, and the priority weight ratio is 1:20 to 20:1.
- the composition may be prepared from any of the active ingredients, supplemented with a pesticide-acceptable excipient, in any form suitable for agricultural use, such as an aqueous emulsion, microemulsion or suspension.
- a pesticide-acceptable excipient in any form suitable for agricultural use, such as an aqueous emulsion, microemulsion or suspension.
- the active ingredient has a mass content of from 5 to 85%.
- the adjuvant, solvent, and carrier auxiliary component which are usually used in the pesticide preparation of the composition are prepared into various dosage forms suitable for use in agriculture.
- composition of the present invention can be prepared into various dosage forms by a known method, and the active ingredient and an auxiliary agent such as a solvent, a carrier (such as a solid carrier) can be uniformly mixed and ground with a surfactant as needed, and prepared.
- auxiliary agent such as a solvent, a carrier (such as a solid carrier)
- Suitable auxiliaries may be solid or liquid, they are usually materials commonly used in the processing of dosage forms, such as natural or regenerated minerals, solvents, dispersants, wetting agents, adhesives, thickeners, adhesives, surfaces. Active agent or fertilizer.
- the above solvent may be selected from aromatic hydrocarbons, preferably containing from 8 to 12 carbon atoms, such as a mixture of xylenes or substituted benzenes, phthalates such as dibutyl phthalate or dicaprylic acid, aliphatic hydrocarbons such as rings.
- aromatic hydrocarbons preferably containing from 8 to 12 carbon atoms, such as a mixture of xylenes or substituted benzenes, phthalates such as dibutyl phthalate or dicaprylic acid, aliphatic hydrocarbons such as rings.
- Alkenes or paraffins, alcohols and glycols and their ethers and esters such as ethanol, ethylene glycol, ethylene glycol monomethyl
- ketones such as cyclohexanone
- highly polar solvents such as N-methyl-2 Pyrrolidone, dimethyl sulfoxide or dimethylformamide
- vegetable or vegetable oils such as soybean oil.
- the above carriers are typically natural mineral fillers such as talc, kaolin, montmorillonite or activated clay.
- a highly dispersible silicic acid or a highly dispersible adsorbent polymer carrier such as a particulate adsorbent carrier or a non-adsorbing carrier, and a suitable particulate adsorbent carrier is porous, such as pumice, bentonite or Bentonite; a suitable non-adsorbing carrier such as calcite or sand.
- a large amount of pre-granulated materials of inorganic or organic nature can be used as a carrier, in particular dolomite.
- Suitable surfactants are lignosulfonic acid, naphthalenesulfonic acid, phenolsulfonic acid, alkaline earth metal or amine salts, alkylarylsulfonates, alkyl groups Sulfates, alkyl sulfonates, fatty alcohol sulphates, fatty acids and sulfated fatty alcohol glycol ethers, as well as condensates of sulfonated naphthalene and naphthalene derivatives with formaldehyde, naphthalene or naphthalene sulfonic acid with phenol and formaldehyde Condensate, polyoxyethylene octyl phenyl ether, ethoxylated isooctyl phenol, octyl phenol, nonyl phenol, alkyl aryl polyglycol ether, tributyl benzene poly
- the method of application of the compositions of the present invention comprises the use of the compositions of the present invention in aerial parts of plants, including leaves or foliage.
- the plant's growth site such as wheat
- the plant's growth site such as wheat
- the composition may be applied to the soil in solid form, such as in the form of granules (soil application), the composition may be passed from the soil to the plant through the roots of the plant.
- In vivo systemic action
- compositions may be applied only by the active ingredient or may be used in combination with the additives, and thus the compositions of the present invention may be prepared in various dosage forms such as wettable powders, water-dispersible granules, aqueous emulsions, microemulsions.
- the compositions may be applied by spraying, misting, dusting, spreading or pouring, and the like.
- the two active ingredients in the composition of the present invention exhibit synergistic effects and are more remarkable than the individual activities of individual compounds, and can be used for controlling crop pests in the agricultural field.
- the synergistic effect is manifested by allowing a reduction in the amount of application, a broader insecticidal spectrum, quicker effect, and longer lasting protection.
- the therapeutic effect better control of the pest by only one or a few applications, and widening the possible application interval.
- the insecticidal composition of the invention has good activity in various plant diseases such as wheat, cotton, corn, soybean, vegetable, fruit tree and the like. In particular, it has excellent effects in controlling crop pests caused by hibiscus, leaf miner, thrips, aphids, red spiders or small green leafhoppers.
- the other characteristics of this product are mainly as follows: 1. It can be applied to various possible application methods such as spraying, seed dressing and mixed soil spreading; 2. The chemical composition of the two single agents of the composition is very different, There is cross-resistance, which can delay the resistance problem caused by the two single agents alone; 3. The compounding of the composition of the invention has obvious synergistic effect, and is safe and effective against crops. It has been proved by experiments that the composition of the invention has stable chemical properties, remarkable synergistic effect, and exhibits obvious synergistic effect and complementary effect on the control object.
- the active ingredients of flumethrin and bifenthrin are mixed with the dispersing agent, stabilizer, antifoaming agent and solvent in the proportion of the formula, ground in a sanding kettle, and then sent to a homomixer. Mix well to get the finished product.
- the active ingredient flumethrin and bifenthrin are mixed with the solvent and the auxiliary agent under mechanical stirring, then the emulsifier and the stabilizer are added to be evenly stirred, and finally water is added at 100-12000 rpm. Stir at a speed of 10-30 minutes to make it a homogeneous milky product.
- Example 5 31% flumethrin-bifenthrin aqueous emulsion
- Example 6 31% flumethrin-bifenthrin aqueous emulsion
- Example 7 10% flumethrin-bifenthrin aqueous emulsion
- Example 8 51% flumethrin bifenthrin aqueous emulsion
- Example 9 51% flumethrin-bifenthrin aqueous emulsion
- the leaves without application of insecticide were cut into 5cm in diameter, and the test agents were sprayed evenly on the positive and negative sides of the leaves with a sprayer. After drying, they were transferred to the culture dish and connected to the 2nd instar larvae. Each treatment was 50 times and repeated 4 times. And with water control.
- the rice was reared at room temperature, 75%-85% relative humidity at 25 °C, and the new rice leaves treated with the drug were replaced every 12 hours. The number of deaths was checked after 48 hours, the mortality was calculated, and the mortality was corrected. Lethal concentration.
- Measured virulence index (ATI) (standard drug LC50 / test drug LC50) * 100
- Theoretical virulence index (TTI) A virulence index * Percentage of A in the mixture + B virulence index * Percentage of B in the mixture
- CTC Co-toxicity coefficient [mixture measured virulence index (ATI) / mixed theory virulence index (TTI)] * 100
- CTC ⁇ 80 the composition showed antagonism, 80 ⁇ CTC ⁇ 120, the composition showed an additive effect, CTC ⁇ 120, and the composition showed synergistic effect.
- the field efficacy test was repeated 4 times for each treatment, and the whole plant was evenly sprayed at the peak of the occurrence of the damage.
- Each processing cell immediately takes 5 points, each point 10 plants were calibrated, the number of insect populations was investigated before application, and the number of live insects was recorded 5 days after application. The rate of reduction of insects was calculated, that is, the control effect was observed. At the same time, the symptoms of the tested crops were investigated to determine the safety of the medicament.
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Abstract
The present invention provides an insect-killing mite-killing agent composition with a synergistic effect. The composition comprises two effective components A and B, wherein the active component A is acrinathrin, the active component B is bifenthrin, and the two components have a weight ratio of 1:50 to 50:1. The present invention also provides a preparation method for and an application of the composition. Experiment results show that the insect-killing composition provided by the present invention has an obvious synergistic effect, the use amount can be reduced, and the control cost is reduced. The insect-killing mite-killing composition is capable of effectively controlling multiple types of insects in fruit trees, vegetables and commercial crops. By compounding insecticides with different mechanisms and acting modes, the application amount of a single agent is effectively reduced, and good effects are provided in expanding an insecticidal spectrum, delaying drug resistance of insects, improving the control effect and the like.
Description
本发明涉及一种具有改进性能的杀虫杀螨组合物，具体地说是涉及一种包含氟丙菊酯和联苯菊酯的杀虫杀螨组合物，属于农药制剂领域。The present invention relates to an insecticidal and acaricidal composition having improved properties, and more particularly to an insecticidal and acaricidal composition comprising flumethrin and bifenthrin, and belongs to the field of pesticide preparations.
氟丙菊酯(acrinathrin)属于高效、低毒、广谱、新型的拟除虫菊酯类杀螨、杀虫剂。对多种食植性害螨肯具有良好的活性，并对刺吸口器害虫和鳞翅目害虫，如木虱、潜叶蛾、蓟马、蚜虫等也具有良好的活性。用于棉花、果树、大豆、玉米、蔬菜、茶叶、葡萄、柑橘、烟草等作物。Acerithrin is a high-efficiency, low-toxic, broad-spectrum, novel pyrethroid-killing insecticide and insecticide. It has good activity against a variety of food-borne pests, and also has good activity against pests and lepidopteran pests such as hibiscus, leaf miner, thrips and aphids. Used in crops such as cotton, fruit trees, soybeans, corn, vegetables, tea, grapes, citrus, and tobacco.
联苯菊酯(bifenthrin)是一种高效合成除虫菊酯杀虫、杀螨剂。具有触杀、胃毒作用，无内吸、熏蒸作用。杀虫谱广，对螨也有较好防效。作用迅速。在土壤中不移动，对环境较为安全，残效期长。Bifenthrin is a highly effective pyrethroid insecticide and acaricide. It has contact, stomach toxicity, no systemic and fumigation effects. It has a wide spectrum of insecticides and good control effect against cockroaches. Act quickly. It does not move in the soil, it is safer for the environment, and the residual effect period is long.
现已有研究表明，长期重复且专一施用一种活性化合物来防治害虫在很多情况下将导致害虫的抗药性增强，为降低害虫抗药性，目前通常使用不同活性化合物的混合物来防治害虫。通过将具有不同活性的化合物进行组合，可延缓抗性产生，降低施用量，提高防治效果，并减少防治成本。Studies have shown that long-term repeated and specific application of an active compound to control pests will in many cases lead to increased resistance of pests. To reduce pest resistance, mixtures of different active compounds are currently commonly used to control pests. By combining compounds having different activities, resistance generation can be delayed, application amount can be reduced, control effect can be improved, and control cost can be reduced.
发明内容Summary of the invention
本发明的目的是：针对杀虫杀螨剂在实际应用中抗性问题，筛选出两种不同作用原理的杀虫杀螨剂进行复配，以提高作用防治效果，降低施药量，扩大使用范围。The purpose of the invention is to screen the two insecticidal and acaricidal agents with different action principles for the resistance problem of the insecticide and acaricide in the practical application, so as to improve the effect of prevention and treatment, reduce the application amount and expand the use. range.
为实现上述目的，本发明提供了一组杀虫杀螨组合物，该组合物包含两种有效成分A和B，活性组分A为氟丙菊酯，活性组分B为联苯菊酯。发明人通过试验发现，上述杀虫组合物增效明显，施用量减少，可降低使用成本。含有组分A与组分B的化合物结构类型不同，作用机制各异，两者复配能够扩大作用谱，并且可以在一定程度上延缓昆虫抗性的产生，且组分A与组分B之间无交互抗性。To achieve the above object, the present invention provides a group of insecticidal and acaricidal compositions comprising two active ingredients A and B, active ingredient A being flumethrin and active ingredient B being bifenthrin. The inventors found through experiments that the above-mentioned insecticidal composition has obvious synergistic effect, and the application amount is reduced, which can reduce the use cost. The compounds containing component A and component B have different structural types and different mechanisms of action. The combination of the two can broaden the spectrum of action and can delay the generation of insect resistance to a certain extent, and component A and component B There is no cross-resistance.
本发明提供包含两种有效成分A和B组合物的制备方法及在农业领域防治农作物虫害的应用。The present invention provides a preparation method comprising the two active ingredients A and B compositions and an application for controlling crop pests in the agricultural field.
本组合物包含A和B两种活性组分，两组分之间的重量比为1:30～30:1，优先重量比1:20～20:1。The composition comprises two active components A and B, and the weight ratio between the two components is 1:30 to 30:1, and the priority weight ratio is 1:20 to 20:1.
该组合物可以活性组分辅以农药上可接受的辅料制成适合农业使用的任意一种剂型，例如水乳剂、微乳剂或悬浮剂等。在本组合物的剂型中，优选的，活性组分的质量含量为5～85％。The composition may be prepared from any of the active ingredients, supplemented with a pesticide-acceptable excipient, in any form suitable for agricultural use, such as an aqueous emulsion, microemulsion or suspension. In the dosage form of the present composition, preferably, the active ingredient has a mass content of from 5 to 85%.
该组合物的农药制剂中通常使用的助剂、溶剂、载体辅助成分以做成各种适合在农业中使用的剂型。
The adjuvant, solvent, and carrier auxiliary component which are usually used in the pesticide preparation of the composition are prepared into various dosage forms suitable for use in agriculture.
可用已知的方法将本发明的组合物制备成各种剂型，可以将有效成分与助剂，如溶剂、载体(如固体载体)，需要时可以与表面活性剂一起均匀混合、研磨，制备成所需要的剂型。合适的助剂可以是固体或液体，它们通常是剂型加工过程中常用的物质，例如天然的或再生的矿物质，溶剂、分散剂、润湿剂、胶粘剂、增稠剂、粘合剂、表面活性剂或肥料。The composition of the present invention can be prepared into various dosage forms by a known method, and the active ingredient and an auxiliary agent such as a solvent, a carrier (such as a solid carrier) can be uniformly mixed and ground with a surfactant as needed, and prepared. The dosage form required. Suitable auxiliaries may be solid or liquid, they are usually materials commonly used in the processing of dosage forms, such as natural or regenerated minerals, solvents, dispersants, wetting agents, adhesives, thickeners, adhesives, surfaces. Active agent or fertilizer.
上述的溶剂可选自芳香烃，优选含8-12个碳原子，如二甲苯混合物或取代的苯，酞酸酯类，如酞酸二丁酯或酞酸二辛酸，脂肪烃类，如环已烷或石蜡，醇和乙二醇和它们的醚和酯，如乙醇，乙二醇，乙二醇单甲基；酮类，如环已酮，强极性的溶剂，如N-甲基-2-吡咯烷酮，二甲基亚砜或二甲基甲酰胺，和植物油或植物油，如大豆油。The above solvent may be selected from aromatic hydrocarbons, preferably containing from 8 to 12 carbon atoms, such as a mixture of xylenes or substituted benzenes, phthalates such as dibutyl phthalate or dicaprylic acid, aliphatic hydrocarbons such as rings. Alkenes or paraffins, alcohols and glycols and their ethers and esters, such as ethanol, ethylene glycol, ethylene glycol monomethyl; ketones, such as cyclohexanone, highly polar solvents such as N-methyl-2 Pyrrolidone, dimethyl sulfoxide or dimethylformamide, and vegetable or vegetable oils such as soybean oil.
上述的载体(如固体载体)，如用于粉剂和可分散剂的通常是天然矿物填料，例如滑石、高岭土，蒙脱石或活性白土。为了管理组合物的物理性能，也可以加入高分散性硅酸或高分散性吸附聚合物载体，例如粒状吸附载体或非吸附载体，合适的粒状吸附载体是多孔型的，如浮石、皂土或膨润土；合适的非吸附载体如方解石或砂。另外，可以使用大量的无机性质或有机性质的预制成粒状的材料作为载体，特别是白云石。The above carriers (e.g., solid carriers), such as those used in powders and dispersibles, are typically natural mineral fillers such as talc, kaolin, montmorillonite or activated clay. In order to manage the physical properties of the composition, it is also possible to add a highly dispersible silicic acid or a highly dispersible adsorbent polymer carrier, such as a particulate adsorbent carrier or a non-adsorbing carrier, and a suitable particulate adsorbent carrier is porous, such as pumice, bentonite or Bentonite; a suitable non-adsorbing carrier such as calcite or sand. In addition, a large amount of pre-granulated materials of inorganic or organic nature can be used as a carrier, in particular dolomite.
根据本发明的组合物中的有效成分的化学性质，合适的表面活性剂为木质素磺酸、萘磺酸、苯酚磺酸、碱土金属盐或胺盐，烷基芳基磺酸盐，烷基硫酸盐，烷基磺酸盐，脂肪醇硫酸盐，脂肪酸和硫酸化脂肪醇乙二醇醚，还有磺化萘和萘衍生物与甲醛的缩合物，萘或萘磺酸与苯酚和甲醛的缩合物，聚氧乙烯辛基苯基醚，乙氧基化异辛基酚，辛基酚，壬基酚，烷基芳基聚乙二醇醚，三丁基苯聚乙二醇醚，三硬脂基苯基聚乙二醇醚，烷基芳基聚醚醇，乙氧基化蓖麻油，聚氧乙烯烷基醚，氧化乙烯缩合物、乙氧基化聚氧丙烯，月桂酸聚乙二醇醚缩醛，山梨醇酯，木质素亚硫酸盐废液和甲基纤维素。Suitable surfactants according to the chemical nature of the active ingredient in the composition of the present invention are lignosulfonic acid, naphthalenesulfonic acid, phenolsulfonic acid, alkaline earth metal or amine salts, alkylarylsulfonates, alkyl groups Sulfates, alkyl sulfonates, fatty alcohol sulphates, fatty acids and sulfated fatty alcohol glycol ethers, as well as condensates of sulfonated naphthalene and naphthalene derivatives with formaldehyde, naphthalene or naphthalene sulfonic acid with phenol and formaldehyde Condensate, polyoxyethylene octyl phenyl ether, ethoxylated isooctyl phenol, octyl phenol, nonyl phenol, alkyl aryl polyglycol ether, tributyl benzene polyglycol ether, three Stearyl phenyl polyglycol ether, alkyl aryl polyether alcohol, ethoxylated castor oil, polyoxyethylene alkyl ether, ethylene oxide condensate, ethoxylated polyoxypropylene, lauric acid poly Glycol ether acetal, sorbitol ester, lignin sulfite waste liquor and methyl cellulose.
本发明组合物的施用方法包括将本发明的组合物用于植物生长的地上部分，包括叶部或叶面。可以将植物的生长场所，如小麦，用组合物的液体制剂浸湿，或者将组合物以固体形式施用于土壤中，如以颗粒形式(土壤施用)，组合物可以由土壤经植物根部进入植物体内(内吸作用)。The method of application of the compositions of the present invention comprises the use of the compositions of the present invention in aerial parts of plants, including leaves or foliage. The plant's growth site, such as wheat, may be wetted with a liquid formulation of the composition, or the composition may be applied to the soil in solid form, such as in the form of granules (soil application), the composition may be passed from the soil to the plant through the roots of the plant. In vivo (systemic action).
这些组合物可以仅仅包含活性成分进行施用，也可以与添加剂一起混合使用，因此本发明的组合物可以制备成各种剂型，例如可湿性粉剂、水分散粒剂、水乳剂、微乳剂。根据这些组合物的性质以及施用组合物所要达到的目的和环境情况，可以选择将组合物以喷雾、弥雾、喷粉、撒播或泼浇等之类的方法施用。These compositions may be applied only by the active ingredient or may be used in combination with the additives, and thus the compositions of the present invention may be prepared in various dosage forms such as wettable powders, water-dispersible granules, aqueous emulsions, microemulsions. Depending on the nature of the compositions and the intended purpose and environmental conditions to which the compositions are to be applied, the compositions may be applied by spraying, misting, dusting, spreading or pouring, and the like.
本发明的组合物中两种有效成分表现为增效效果，比单个化合物的单独活性更为显著，它可以在农业领域防治农作物虫害的应用。增效效果表现为允许施用量减少、更宽的杀虫谱、见效快、更持久的防
治效果、通过仅仅一次或少数几次施用更好的控制害虫、以及加宽了可能的施用间隔时间。这些特性对解决杀虫剂单剂普遍存在的抗性问题是非常重要的。The two active ingredients in the composition of the present invention exhibit synergistic effects and are more remarkable than the individual activities of individual compounds, and can be used for controlling crop pests in the agricultural field. The synergistic effect is manifested by allowing a reduction in the amount of application, a broader insecticidal spectrum, quicker effect, and longer lasting protection.
The therapeutic effect, better control of the pest by only one or a few applications, and widening the possible application interval. These characteristics are very important to solve the ubiquitous resistance problem of a single pesticide.
本发明的杀虫组合物应用在小麦、棉花、玉米、大豆、蔬菜、果树等各种农作物上多种食植性害螨肯具有良好的活性。特别是在防治木虱、潜叶蛾、蓟马、蚜虫、红蜘蛛或小绿叶蝉引起的农作物虫害方面具有出色的效果。The insecticidal composition of the invention has good activity in various plant diseases such as wheat, cotton, corn, soybean, vegetable, fruit tree and the like. In particular, it has excellent effects in controlling crop pests caused by hibiscus, leaf miner, thrips, aphids, red spiders or small green leafhoppers.
本品表现出的其它特点主要表现为：1、可应用于喷雾、拌种、混土撒播等各种可能的施药方式；2、本组合物的两个单剂化学结构差异很大，不存在交互抗性，可延缓两单剂单独使用所产生的抗性问题；3、本发明的组合物混配具有明显的增效作用，对作物安全、防效好。经试验证明，本发明组合物化学性质稳定，增效显著，对防治对象表现出明显的增效以及互补作用。The other characteristics of this product are mainly as follows: 1. It can be applied to various possible application methods such as spraying, seed dressing and mixed soil spreading; 2. The chemical composition of the two single agents of the composition is very different, There is cross-resistance, which can delay the resistance problem caused by the two single agents alone; 3. The compounding of the composition of the invention has obvious synergistic effect, and is safe and effective against crops. It has been proved by experiments that the composition of the invention has stable chemical properties, remarkable synergistic effect, and exhibits obvious synergistic effect and complementary effect on the control object.
为了使本发明的目的、技术方案及优点更加清楚明白，以下结合实施例，对本发明进行进一步详细说明。应当理解，此处所描述的具体实施例仅用以解释本发明，并不用于限定本发明，凡在本发明的构思前提下对本发明制备方法的简单改进都属于本发明的保护范围之内。In order to make the objects, technical solutions and advantages of the present invention more comprehensible, the present invention will be further described in detail below with reference to the embodiments. It is to be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the scope of the invention.
以下实施例所有配方中百分比均为重量百分比。本发明组合物各种制剂的加工工艺均为现有技术，根据不同情况可以有所变化。The percentages in all formulations in the following examples are percentages by weight. The processing techniques of the various formulations of the compositions of the present invention are all prior art and may vary depending on the circumstances.
一、剂型制备实施例First, the dosage form preparation example
(一)悬浮剂的加工及实施例(1) Processing and examples of suspending agents
将活性成分氟丙菊酯和联苯菊酯与分散剂、稳定剂、消泡剂和溶剂等各组分按配方的比例混合，放入砂磨釜内研磨后，送入均质混合器内混匀即得成品。The active ingredients of flumethrin and bifenthrin are mixed with the dispersing agent, stabilizer, antifoaming agent and solvent in the proportion of the formula, ground in a sanding kettle, and then sent to a homomixer. Mix well to get the finished product.
实施例1：21％氟丙菊酯·联苯菊酯悬浮剂Example 1: 21% flumethrin-bifenthrin suspension
氟丙菊酯20％，联苯菊酯1％，白炭黑4％，黄原胶1％，乙二醇1％，水补足至100％。Flumethmethone 20%, bifenthrin 1%, white carbon 4%, xanthan gum 1%, ethylene glycol 1%, water to 100%.
实施例2：21％氟丙菊酯·联苯菊酯悬浮剂Example 2: 21% flumethrin-bifenthrin suspension
氟丙菊酯1％，联苯菊酯20％，脂肪醇聚氧乙烯醚磷酸酯5％,白炭黑5％，丙三醇2％，苯甲酸钠4％，水补足至100％。Flumethmethone 1%, bifenthrin 20%, fatty alcohol polyoxyethylene ether phosphate 5%, white carbon black 5%, glycerol 2%, sodium benzoate 4%, water to 100%.
(二)微乳剂的加工及实施例(2) Processing and examples of microemulsions
将活性成分氟丙菊酯与联苯菊酯在溶剂中完全溶解后，进行搅拌，同时加入乳化剂、增效助剂和抗冻剂，待上述体系混匀后，再将水慢慢加入上述混合液中，充分搅拌后即可配成不同含量的微乳剂。After the active ingredient flumethrin and bifenthrin are completely dissolved in the solvent, stirring is carried out, and an emulsifier, a synergist and an antifreezing agent are added at the same time. After the above system is mixed, the water is slowly added to the above. In the mixed solution, after mixing well, different amounts of microemulsion can be formulated.
实施例3：11％氟丙菊酯·联苯菊酯微乳剂Example 3: 11% flumethrin-bifenthrin microemulsion
氟丙菊酯10％，联苯菊酯1％，丙酮12％,复硝酚钠0.6％，烷基聚氧乙烯醚和壬基酚聚氧乙烯醚6％，丙二醇2％，尿素2％，水补足至100％。
Flumethmethone 10%, bifenthrin 1%, acetone 12%, sodium nitrophenolate 0.6%, alkyl polyoxyethylene ether and nonylphenol ethoxylate 6%, propylene glycol 2%, urea 2%, The water is made up to 100%.
实施例4：11％氟丙菊酯·联苯菊酯微乳剂Example 4: 11% flumethrin-bifenthrin microemulsion
氟丙菊酯1％，联苯菊酯10％，烷基苯磺酸盐和烷基萘磺酸盐15％，噻酮2％，乙酸乙酯13％,丙二醇2％，水补足至100％。1% flumethrin, 10% bifenthrin, 15% alkyl benzene sulfonate and alkyl naphthalene sulfonate, 2% thione, 13% ethyl acetate, 2% propylene glycol, water up to 100% .
(三)水乳剂的加工及实施例(III) Processing and examples of water emulsion
在乳化釜中，将活性成分氟丙菊酯和联苯菊酯与溶剂、助剂在机械搅拌下混合均匀，然后投入乳化剂和稳定剂搅拌均匀，最后加入水，在100-12000转/分钟的转速下搅拌10-30分钟，使之成为均匀乳状的产品。In the emulsifier, the active ingredient flumethrin and bifenthrin are mixed with the solvent and the auxiliary agent under mechanical stirring, then the emulsifier and the stabilizer are added to be evenly stirred, and finally water is added at 100-12000 rpm. Stir at a speed of 10-30 minutes to make it a homogeneous milky product.
实施例5：31％氟丙菊酯·联苯菊酯水乳剂Example 5: 31% flumethrin-bifenthrin aqueous emulsion
氟丙菊酯30％，联苯菊酯1％，聚异丁二酸酐-聚乙二醇共聚物3％，聚乙烯醇2％，丙二醇1％，黄原胶3％，丁基羟基茴香醚3％,有机硅消泡剂1.2％，水补足至100％。Flumethmethone 30%, bifenthrin 1%, polyisosuccinic anhydride-polyethylene glycol copolymer 3%, polyvinyl alcohol 2%, propylene glycol 1%, xanthan gum 3%, butylated hydroxyanisole 3%, silicone defoamer 1.2%, water to 100%.
实施例6：31％氟丙菊酯·联苯菊酯水乳剂Example 6: 31% flumethrin-bifenthrin aqueous emulsion
氟丙菊酯1％，联苯菊酯30％，N-十二烷基吡咯烷酮1％,蓖麻油聚氧乙烯醚2％，丙三醇2％，聚乙烯醇2％，苯甲酸钠2％，异辛醇3％，水补足至100％。Flumethmethone 1%, bifenthrin 30%, N-dodecylpyrrolidone 1%, castor oil polyoxyethylene ether 2%, glycerol 2%, polyvinyl alcohol 2%, sodium benzoate 2%, Isooctyl alcohol 3%, water to 100%.
实施例7：10％氟丙菊酯·联苯菊酯水乳剂Example 7: 10% flumethrin-bifenthrin aqueous emulsion
氟丙菊酯5％，联苯菊酯5％，N-邻苯二甲酸二甲酯3％，壬基酚苯氧乙烯醚5％，乙二醇1％，苯甲酸钠2％，2,6-二叔丁基-4-甲基苯酚2％，聚乙烯醇3％，有机硅消泡剂1％，水补足至100％。Flumethmethrin 5%, bifenthrin 5%, dimethyl N-phthalate 3%, nonylphenol phenoxy ether 5%, ethylene glycol 1%, sodium benzoate 2%, 2,6 2-di-tert-butyl-4-methylphenol 2%, polyvinyl alcohol 3%, silicone defoamer 1%, water up to 100%.
实施例8：51％氟丙菊酯·联苯菊酯水乳剂Example 8: 51% flumethrin bifenthrin aqueous emulsion
氟丙菊酯50％，联苯菊酯1％，苯甲酸钠2％，2,6-二叔丁基-4-甲基苯酚3％，N-邻苯二甲酸二甲酯2％，有机硅消泡剂2％，壬基酚苯氧乙烯醚2％，乙二醇0.2％，聚乙烯醇3％，水补足至100％。Flumethmethone 50%, bifenthrin 1%, sodium benzoate 2%, 2,6-di-tert-butyl-4-methylphenol 3%, N-phthalic acid dimethyl ester 2%, silicone Defoamer 2%, nonylphenol phenoxy ether 2%, ethylene glycol 0.2%, polyvinyl alcohol 3%, water to 100%.
实施例9：51％氟丙菊酯·联苯菊酯水乳剂Example 9: 51% flumethrin-bifenthrin aqueous emulsion
氟丙菊酯1％，联苯菊酯50％，蓖麻油聚氧乙烯醚2％，丙三醇2％，聚乙烯醇2％，N-十二烷基吡咯烷酮2.5％,聚乙烯醇3％，异辛醇4％，水补足至100％。Flumethmethone 1%, bifenthrin 50%, castor oil polyoxyethylene ether 2%, glycerol 2%, polyvinyl alcohol 2%, N-dodecylpyrrolidone 2.5%, polyvinyl alcohol 3% , isooctyl alcohol 4%, water to 100%.
二、药效验证试验Second, the efficacy test
(一)室内毒力活性测定(1) Determination of indoor virulence activity
实施例1氟丙菊酯与联苯菊酯复配对苹果红蜘蛛毒力测定试验Example 1 flumethrin and bifenthrin complex pairing apple red spider virulence test
1.1供试药剂1.1 test drug
氟丙菊酯原药、联苯菊酯原药Flumethrin original drug, bifenthrin original drug
1.2供试虫源1.2 Test insect source
苹果红蜘蛛Apple red spider
1.3测定方法
1.3 Determination method
无施用过杀虫剂的叶片剪成直径5cm，供试药剂分别用喷雾器均匀喷在菜叶正、反面，晾干后移入培养皿，接入2龄幼虫，每处理50头，重复4次，并以清水对照。于25℃室温、75％-85％相对湿度下饲养，每隔12h更换药剂处理过的新水稻叶片，48h后检查死亡数，计算死亡率，并以对照的死亡率进行校正，以此求得致死中浓度。The leaves without application of insecticide were cut into 5cm in diameter, and the test agents were sprayed evenly on the positive and negative sides of the leaves with a sprayer. After drying, they were transferred to the culture dish and connected to the 2nd instar larvae. Each treatment was 50 times and repeated 4 times. And with water control. The rice was reared at room temperature, 75%-85% relative humidity at 25 °C, and the new rice leaves treated with the drug were replaced every 12 hours. The number of deaths was checked after 48 hours, the mortality was calculated, and the mortality was corrected. Lethal concentration.
1.4数据分析1.4 Data Analysis
按有效成分百分比氟丙菊酯：联苯菊酯配比为：30:1、20:1、10:1、1:1、1:10、1:20、1:30进行试验，依孙云沛法计算药剂的毒力指数级共毒系数(CTC)。According to the percentage of active ingredient, flumethrin: bifenthrin ratio: 30:1, 20:1, 10:1, 1:1, 1:10, 1:20, 1:30, according to Sun Yunpei method Calculate the virulence index-level co-toxicity coefficient (CTC) of the agent.
实测毒力指数(ATI)＝(标准药剂LC50/供试药剂LC50)*100Measured virulence index (ATI) = (standard drug LC50 / test drug LC50) * 100
理论毒力指数(TTI)＝A药剂毒力指数*混剂中A的百分含量+B药剂毒力指数*混剂中B的百分含量Theoretical virulence index (TTI) = A virulence index * Percentage of A in the mixture + B virulence index * Percentage of B in the mixture
共毒系数(CTC)＝[混剂实测毒力指数(ATI)/混剂理论毒力指数(TTI)]*100Co-toxicity coefficient (CTC) = [mixture measured virulence index (ATI) / mixed theory virulence index (TTI)] * 100
CTC≤80，组合物表现为拮抗作用，80＜CTC＜120，组合物表现为相加作用，CTC≥120，组合物表现为增效作用。CTC ≤ 80, the composition showed antagonism, 80 < CTC < 120, the composition showed an additive effect, CTC ≥ 120, and the composition showed synergistic effect.
表1氟丙菊酯、联苯菊酯及其不同配比复配对苹果红蜘蛛毒力测定结果分析Table 1 Analysis of virulence determination of flumethrin, bifenthrin and its different ratios against apple red spider
结果(表1)表明，氟丙菊酯与联苯菊酯复配对苹果红蜘蛛的防治效果显著提高，说明二者复配对苹果红蜘蛛有显著的防治作用。尤其是氟丙菊酯与联苯菊酯配比在1:20～20:1之间，氟丙菊酯与联苯菊酯的共毒系数均在150以上，增效作用明显。The results (Table 1) showed that the control effect of the combination of flumethrin and bifenthrin on apple red spider was significantly improved, indicating that the two pairs of apple red spider had significant control effect. In particular, the ratio of flumethrin to bifenthrin is between 1:20 and 20:1, and the co-toxicity coefficient of flumethrin and bifenthrin is above 150, and the synergistic effect is obvious.
(二)田间药效验证试验(2) Field efficacy test
田间药效试验每个处理重复4次，于螨害发生高峰期全株均匀喷雾。每处理小区随即取5点，每点
标定10棵植株，施药前调查虫口基数，施药后5天记载残留活虫数，计算虫口减退率，即防治效果，同时调查供试作物有无药害症状，确定药剂的安全性。The field efficacy test was repeated 4 times for each treatment, and the whole plant was evenly sprayed at the peak of the occurrence of the damage. Each processing cell immediately takes 5 points, each point
10 plants were calibrated, the number of insect populations was investigated before application, and the number of live insects was recorded 5 days after application. The rate of reduction of insects was calculated, that is, the control effect was observed. At the same time, the symptoms of the tested crops were investigated to determine the safety of the medicament.
预期防效(％)＝X+Y-XY/100(其中，X，Y为单剂防效)Expected control effect (%) = X + Y-XY / 100 (where X, Y is a single dose control)
表2.氟丙菊酯与联苯菊酯复配对柑橘红蜘蛛的田间防效试验结果Table 2. Field control trial results of flumethrin and bifenthrin complexed with Citrus red spider
测定结果(表2)表明，氟丙菊酯与联苯菊酯复配对防治柑橘红蜘蛛的防效明显提高，说明二者复配对柑橘红蜘蛛有显著的协同增效作用。在整个试验过程中，在本发明组合物制剂的用量范围内，未发现对柑橘生长的药害现象，说明本发明的组合物对柑橘生长是安全的。
The results of the determination (Table 2) showed that the combination of flumethrin and bifenthrin significantly improved the control effect of citrus red spider, indicating that the two pairs of citrus red spider had significant synergistic effect. During the entire test, no phytotoxicity to citrus growth was observed in the range of the amount of the composition of the present invention, indicating that the composition of the present invention is safe for citrus growth.
Claims (10)
- 具有增效作用的杀虫杀螨剂组合物，其特征在于该组合物包含A和B两种活性组分，其中活性组分A为氟丙菊酯，活性组分B为联苯菊酯，两组分之间的重量比为1:50～50:1。A synergistic insecticidal and acaricidal composition, characterized in that the composition comprises two active components A and B, wherein the active component A is flumethrin and the active component B is bifenthrin. The weight ratio between the two components is from 1:50 to 50:1.
- 根据权利要求1所述组合物，其特征在于活性组分A氟丙菊酯与活性组分B联苯菊酯的重量比为1:30～30:1。The composition according to Claim 1, characterized in that the weight ratio of the active ingredient A flumethrin to the active ingredient B bifenthrin is from 1:30 to 30:1.
- 根据权利要求1或2所述组合物，其特征在于活性组分A氟丙菊酯与活性组分B联苯菊酯的重量比为1:20～20:1。The composition according to claim 1 or 2, characterized in that the weight ratio of the active ingredient A flumethrin to the active ingredient B bifenthrin is from 1:20 to 20:1.
- 根据权利要求1、2或3所述的组合物，其特征在于该组合物以活性组分辅以农药上可接受的辅料制成适合农业使用的任意一种剂型。A composition according to Claim 1, 2 or 3, characterized in that the composition is prepared from any of the active ingredients in combination with a pesticide-acceptable excipient.
- 根据权利要求4所述的组合物，其特征在于该组合物的剂型中活性组分的质量含量为5～85％。The composition according to claim 4, characterized in that the active ingredient in the dosage form of the composition has a mass content of from 5 to 85%.
- 根据权利要求4所述的组合物，其特征在于所述农药上可接受的辅料包括助剂、溶剂或载体辅助成分；其中所述助剂选自矿物质、溶剂、分散剂、润湿剂、胶粘剂、增稠剂、粘合剂、表面活性剂或肥料中的一种或几种。The composition according to claim 4, wherein the pesticide-acceptable adjuvant comprises an adjuvant, a solvent or a carrier auxiliary component; wherein the adjuvant is selected from the group consisting of minerals, solvents, dispersants, wetting agents, One or more of an adhesive, thickener, binder, surfactant, or fertilizer.
- 根据权利要求6所述的组合物，其特征在于所述溶剂选自二甲苯、酞酸二丁酯、酞酸二辛酸、环已烷、石蜡、乙醇，乙二醇、乙二醇单甲基、环已酮、N-甲基-2-吡咯烷酮、二甲基亚砜、二甲基甲酰胺或大豆油；所述载体选自滑石、高岭土、蒙脱石、活性白土、浮石、皂土、膨润土、方解石、砂或白云石；所述表面活性剂为木质素磺酸、萘磺酸、苯酚磺酸、碱土金属盐、胺盐、烷基芳基磺酸盐、烷基硫酸盐、烷基磺酸盐、脂肪醇硫酸盐、脂肪酸和硫酸化脂肪醇乙二醇醚、磺化萘和萘衍生物与甲醛的缩合物、萘或萘磺酸与苯酚和甲醛的缩合物、聚氧乙烯辛基苯基醚、乙氧基化异辛基酚、辛基酚、壬基酚、烷基芳基聚乙二醇醚、三丁基苯聚乙二醇醚、三硬脂基苯基聚乙二醇醚、烷基芳基聚醚醇、乙氧基化蓖麻油、聚氧乙烯烷基醚、氧化乙烯缩合物、乙氧基化聚氧丙烯、月桂酸聚乙二醇醚缩醛、山梨醇酯、木质素亚硫酸盐废液或甲基纤维素。The composition according to claim 6, wherein the solvent is selected from the group consisting of xylene, dibutyl phthalate, dioctanoic acid decanoic acid, cyclohexane, paraffin, ethanol, ethylene glycol, ethylene glycol monomethyl , cyclohexanone, N-methyl-2-pyrrolidone, dimethyl sulfoxide, dimethylformamide or soybean oil; the carrier is selected from the group consisting of talc, kaolin, montmorillonite, activated clay, pumice, bentonite, Bentonite, calcite, sand or dolomite; the surfactant is lignosulfonic acid, naphthalenesulfonic acid, phenolsulfonic acid, alkaline earth metal salt, amine salt, alkylarylsulfonate, alkyl sulfate, alkyl Sulfonates, fatty alcohol sulfates, fatty acid and sulfated fatty alcohol glycol ethers, condensates of sulfonated naphthalene and naphthalene derivatives with formaldehyde, condensates of naphthalene or naphthalenesulfonic acid with phenol and formaldehyde, polyoxyethylene octane Phenyl phenyl ether, ethoxylated isooctyl phenol, octyl phenol, nonyl phenol, alkyl aryl polyglycol ether, tributyl phenyl polyglycol ether, tristearyl phenyl polyethylene Glycol ether, alkyl aryl polyether alcohol, ethoxylated castor oil, polyoxyethylene alkyl ether, ethylene oxide condensate, ethoxylate Polyoxypropylene laurate polyglycol ether acetal, sorbitol esters, lignin-sulfite waste liquors or methylcellulose.
- 根据权利要求4或5所述的组合物，其特征在于所述剂型为水乳剂、微乳剂或悬浮剂。Composition according to claim 4 or 5, characterized in that the dosage form is an aqueous emulsion, a microemulsion or a suspension.
- 权利要求1至5任一项所述的组合物在农业领域防治农作物虫害的应用。Use of the composition according to any one of claims 1 to 5 for controlling crop pests in the agricultural field.
- 根据权利要求9所述的应用，其特征在于所述农作物虫害为木虱、潜叶蛾、蓟马、蚜虫、红蜘蛛或小绿叶蝉引起的农作物虫害。 The use according to claim 9, characterized in that the crop pest is a crop pest caused by hibiscus, leaf miner, thrips, aphids, red spider or small green leafhopper.
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| CN101384174A (en) * | 2005-12-22 | 2009-03-11 | Fmc有限公司 | Insecticidal and miticidal mixtures of bifenthrin and cyano-pyrethroids |
| CN104397011A (en) * | 2014-11-04 | 2015-03-11 | 江苏辉丰农化股份有限公司 | Insect-killing mite-killing agent composition with synergic effect |
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2014
- 2014-11-04 CN CN201410612137.2A patent/CN104397011B/en active Active
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101384174A (en) * | 2005-12-22 | 2009-03-11 | Fmc有限公司 | Insecticidal and miticidal mixtures of bifenthrin and cyano-pyrethroids |
| CN104397011A (en) * | 2014-11-04 | 2015-03-11 | 江苏辉丰农化股份有限公司 | Insect-killing mite-killing agent composition with synergic effect |
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| CN104397011B (en) | 2017-03-22 |
| CN104397011A (en) | 2015-03-11 |
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