WO2016068405A1 - Porous hand acupuncture needle and manufacturing method therefor - Google Patents

Porous hand acupuncture needle and manufacturing method therefor Download PDF

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Publication number
WO2016068405A1
WO2016068405A1 PCT/KR2015/002432 KR2015002432W WO2016068405A1 WO 2016068405 A1 WO2016068405 A1 WO 2016068405A1 KR 2015002432 W KR2015002432 W KR 2015002432W WO 2016068405 A1 WO2016068405 A1 WO 2016068405A1
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Prior art keywords
needle
resin needle
porous resin
porous
resin
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PCT/KR2015/002432
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French (fr)
Korean (ko)
Inventor
인수일
김혜림
김현식
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재단법인대구경북과학기술원
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Publication of WO2016068405A1 publication Critical patent/WO2016068405A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H39/00—Devices for locating or stimulating specific reflex points of the body for physical therapy, e.g. acupuncture
    • A61H39/08—Devices for applying needles to such points, i.e. for acupuncture ; Acupuncture needles or accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H39/00—Devices for locating or stimulating specific reflex points of the body for physical therapy, e.g. acupuncture

Definitions

  • the present invention relates to a resin needle and a method of manufacturing the same in which a large amount of holes of micro to nano size are formed on a surface thereof.
  • Acupuncture is a device made to penetrate the skin, and is generally made of a metal whose strength and biological safety has been confirmed, and a conventional resin needle is composed of acupuncture, stagnation, and acupuncture as shown in FIG. 1, and includes stones, gold, silver, Made using materials such as copper, iron, bone and barbed.
  • stainless steel 304 or 316L is used as a saliva material, which is hard and not easily broken, resistant to corrosion and harmful to humans.
  • a silicone film was applied to the needle surface to reduce friction between the needle and human tissue during needle acupuncture, and the needle surface was smoothed to reduce the surface roughness, thereby reducing the resistance caused when the needle penetrates into the tissue. To reduce the pain the patient feels.
  • thinner needles are manufactured and used more and more, because the pain of the patient is reduced when the needle is inserted.
  • injection needles The purpose of using needles (injection needles) is to inject certain drugs into body tissues such as blood vessels and muscles through needles, and does not expect a direct therapeutic effect by inserting the needles.
  • resin needles do not aim to inject drugs, and the needle is inserted into specific sites such as meridians and acupuncture points to achieve a therapeutic effect.
  • needles are considered to have important physical stimulation of body tissues when sleeping.
  • needles are made in a manner similar to a method of manufacturing a general needle that smoothes the surface of the needle for the purpose of reducing the pain felt by the patient when sleeping.
  • the pain felt by the patient according to the condition of the surface of the saliva can be reduced, but there is no experimental result that the acupuncture treatment effect is the same.
  • a technique for changing the needle surface properties which are generally used for needle production, was to apply a chemical to the needle surface.
  • the purpose of this technique can be divided into two types according to the application materials, such as the application of materials such as silicone (silicone) for lubrication purposes and the application of salicylic acid for antibacterial and therapeutic purposes, but these techniques
  • the needle produced by this is a problem that the adhesion between the needle surface and the connective tissue is reduced.
  • the main needle and resin needles are mainly used for stainless steel, and among them, ss304 (STS304) is used a lot, all of which belong to the austenitic series.
  • One method of reducing the surface roughness of such stainless steels is electropolishing, and is a technique particularly well applied to ss304 (STS304).
  • electropolishing is applied to the metal to be polished in the electrolytic solution, a viscous initial oxide layer is formed on the surface of the metal by electrolysis, and a passivation film of metal oxide is formed so that the protruding surface is more bent due to the relatively curved surface. It is a technique that the metal surface becomes flat as a whole. This technique is applied to adjust the surface roughness of the stainless steel.
  • Another technique is the use of powerful lasers to process the surface (laser ablation), which injects a powerful laser pulse beam into the metal to instantaneously ablate the surface material to form a pattern. At this time, the depth of the pattern can be adjusted by adjusting the output of the laser.
  • the technology is currently used for marking not only metals but also silicon wafers for semiconductor manufacturing.
  • the most widely used method for surface treatment of resin needles has been developed in the direction of forming needle tip and reducing surface roughness by mechanical grinding. However, this technique is difficult to form directional surfaces.
  • the present invention not only prevents skin damage due to the surface roughness of the existing resin needles, but also provides a new resin needle and a method for effectively producing the resin needles that can effectively deliver the drug through the resin needles in the human body.
  • the present invention relates to a porous resin needle, characterized in that it comprises 15 to 200 holes per 100 ⁇ m 2 (width ⁇ length, 10 ⁇ m ⁇ 10 ⁇ m) of the surface area of the needle Can be.
  • the holes may have an average diameter of 0.3 ⁇ m to 1.5 ⁇ m, and the holes may have an average depth of 0.2 ⁇ m to 1 ⁇ m.
  • the porous resin needle of the present invention may be characterized in that the drug is supported in the hole.
  • the porous resin needle of the present invention is measured on the basis of the method of calculating the specific surface area after measuring the amount of methylene blue solution buried on the surface of the resin needle, the specific surface area of 9.0 m 2 / g or more, preferably Preferably, the specific surface area may be 10.0 m 2 / g to 11.5 m 2 / g.
  • the porous resin needle of the present invention is iron (Fe) 24% ⁇ 28%, chromium (Cr) 6% ⁇ 10%, carbon (C) 61.5% ⁇ 66%, nickel (Ni) 1.5 % To 3.5% and silicon (Si) 0.1% to 0.5%, preferably 25% to 27% iron (Fe), 7% to 9% chromium (Cr), 62% to 64% carbon (C) (Ni) 2% to 3% and silicon (Si) may be characterized in that it comprises 0.2% to 0.3%.
  • Another aspect of the present invention relates to a method for manufacturing the porous resin needle of the present invention described above, it may be characterized in that to produce a porous resin needle by forming a porous structure on the surface of the needle by performing anodizing process of the needle. .
  • a step of washing the saliva may be performed before the anodizing process, and the washing process may be performed by treating the saliva before anodizing with sonication in acetone, and then in ethanol. After sonication, it may be performed by sonication again in purified water.
  • the anodizing process is carried out in an electrolyte containing the needle and the carbon electrode, the needle is used as a (+) electrode, the carbon electrode is used as a (-) electrode
  • the anodizing process is carried out in an electrolyte containing the needle and the carbon electrode
  • the needle is used as a (+) electrode
  • the carbon electrode is used as a (-) electrode
  • it may be performed by applying a DC of 12V to 30V for 10 minutes to 1 hour.
  • the electrolyte in the preparation method of the present invention, may be characterized in that it comprises one or more selected from aqueous solution of ethylene glycol, and aqueous solution of glycerol.
  • the electrolyte in the preparation method of the present invention, is 0.1 to 0.5% by weight of ammonium fluoride and 1 to 5% by weight of water, preferably 0.1 to 0.3% by weight of ammonium fluoride, and It may be characterized in that the aqueous solution of ethylene glycol containing 1-3% by weight of water.
  • the needle before the anodizing step is 37% to 42.5% of iron (Fe), chromium (Cr) 9.5 when measuring EDS (Energy Dispersive Spectometer) % To 15%, carbon (C) 39% to 45%, nickel (Ni) 2.5% to 6% and silicon (Si) 0.3% to 0.8%, preferably iron (Fe) 38% to 42%, chromium (Cr) 10% to 14%, carbon (C) 40% to 44%, nickel (Ni) 3% to 5% and silicon (Si) may be characterized in that it comprises 0.3% to 0.6%.
  • the porous resin needle after the anodizing process iron (Fe) 24% ⁇ 28%, chromium (Cr) when measuring EDS (Energy Dispersive Spectometer) 6% to 10%, carbon (C) 61.5% to 66%, nickel (Ni) 1.5% to 3.5% and silicon (Si) 0.1% to 0.5%, preferably iron (Fe) 25% to 27%, 7% to 9% of chromium (Cr), 62% to 64% of carbon (C), 2% to 3% of nickel (Ni), and 0.2% to 0.3% of silicon (Si).
  • EDS Electronic Data Dispersive Spectometer
  • the resin needle of the present invention is formed with a hole in the form recessed inward rather than a shape derived from the outside of the needle like a conventional resin needle, there is no problem of skin damage, and a plurality of micro size to nano size on the surface of the needle Since the hole having is uniformly formed, the surface area is significantly increased, and thus the physiological treatment effect by saliva can be increased.
  • the drug can be added to the human body by supporting the drug formed in the hole formed on the surface of the saliva can maximize the effect by the saliva.
  • FIG. 1 is a schematic diagram of a method for producing the porous resin needle of the present invention by an anodizing method.
  • FIG. 2 is a SEM measurement photograph of the surface of the resin needle before and after anodization treatment.
  • the left resin needle of FIG. 2 (a) is a photograph of the resin needle before anodization treatment
  • the right resin needle of FIG. It is a porous resin needle.
  • 2B is a SEM photograph of the surface of the resin needle before anodizing
  • FIGS. 2C and 2D are SEM photographs of the surface of the resin needle after anodizing. .
  • FIG. 3 is an SEM measurement photograph obtained by enlarging and measuring the surface of the resin needle after the anodizing treatment of Example 1 performed in Experimental Example 1.
  • FIG. 3 is an SEM measurement photograph obtained by enlarging and measuring the surface of the resin needle after the anodizing treatment of Example 1 performed in Experimental Example 1.
  • FIG. 4 is an SEM measurement photograph obtained by enlarging and measuring the surface of the resin needle after anodizing prepared in Example 2.
  • FIG. 4 is an SEM measurement photograph obtained by enlarging and measuring the surface of the resin needle after anodizing prepared in Example 2.
  • FIG. 5 is an SEM measurement photograph obtained by enlarging and measuring the surface of the resin needle after the anodization treatment prepared in Example 3.
  • FIG. 5 is an SEM measurement photograph obtained by enlarging and measuring the surface of the resin needle after the anodization treatment prepared in Example 3.
  • FIG. 6 is an SEM measurement photograph obtained by enlarging and measuring the surface of the resin needle after the anodization treatment prepared in Example 4.
  • FIG. 6 is an SEM measurement photograph obtained by enlarging and measuring the surface of the resin needle after the anodization treatment prepared in Example 4.
  • FIG. 7 is an SEM measurement photograph obtained by enlarging and measuring the surface of the resin needle after anodizing prepared in Comparative Example 1.
  • FIG. 7 is an SEM measurement photograph obtained by enlarging and measuring the surface of the resin needle after anodizing prepared in Comparative Example 1.
  • FIG. 8 is an SEM measurement photograph obtained by enlarging and measuring the surface of the resin needle after anodizing prepared in Comparative Example 2.
  • FIG. 8 is an SEM measurement photograph obtained by enlarging and measuring the surface of the resin needle after anodizing prepared in Comparative Example 2.
  • hole used in the present invention means a hole formed in a concave shape in the direction of the needle in the surface direction of the needle.
  • the resin needle of the present invention relates to a resin needle having a porosity formed on the surface of the needle, and may be prepared by forming an nano-sized hole on the surface of the needle by performing an anodizing process.
  • the needle before the anodizing process may be used after performing the washing process, wherein the washing process is to remove foreign substances, etc. on the surface of the needle, it is possible to use a general method in the art, preferably After sonication in acetone, and then sonicated in ethanol, it can be carried out again by sonication in purified water again.
  • each of the ultrasonic treatment time is not particularly limited, but 5 minutes to 20 minutes are appropriate.
  • the needle before the anodizing process may use a needle that is generally sold, preferably 37% to 42.5% of iron (Fe), 9.5% to chromium (Cr) when measuring EDS (Energy Dispersive Spectometer) 15%, 39% to 45% of carbon (C), 2.5% to 6% of nickel (Ni) and 0.3% to 0.8% of silicon (Si), more preferably 38% to 42 of iron (Fe)
  • a needle containing%, chromium (Cr) 10% to 14%, carbon (C) 40% to 44%, nickel (Ni) 3% to 5% and silicon (Si) 0.3% to 0.6% may be used.
  • the needle and the carbon electrode are immersed in an electrolyte, and a DC voltage of 12 V to 30 V is preferable.
  • a voltage of 12V to 28V, more preferably a voltage of 15V to 26V is applied for 10 minutes to 1 hour, preferably 20 minutes to 40 minutes, and the micro size to nano surface of the needle as shown in FIG. It is possible to form holes of size.
  • the voltage is less than 12V, there may be a problem that the hole does not occur on the surface of the resin needle, and if it exceeds 30V, there may be a problem that the resin needle is oxidized and broken, it is preferable to apply a voltage within the above range.
  • the electrolyte solution used in the anodizing process may be used an electrolyte solution used in the anodizing process in the art, preferably at least one selected from an aqueous solution of ethylene glycol and an aqueous solution of glycerol It is good to use an electrolyte containing.
  • aqueous solution of ethylene glycol containing 0.1 to 0.3% by weight of ammonium, 1 to 3% by weight of water and the remaining amount of ethylene glycol, more preferably 0.15 to 0.25% by weight of ammonium fluoride, 1.5 to 2.5% by weight of water, and Ethylene glycol aqueous solution containing the residual amount of ethylene glycol can be used.
  • the ammonium fluoride (NH 4 F) is combined with the oxidized component of the resin needle to play a role of melting the component toward the aqueous solution, 0.1 to 0.5% by weight, preferably 0.1 to 0.3 It is preferable to use it so as to contain a weight%, more preferably 0.2 to 0.25 weight%, if the content is less than 0.1 weight%, the number of holes formed on the surface of the resin needle is reduced, there may be a problem that the average depth and size decreases If the content is more than 0.5% by weight, holes may not be formed on the surface of the resin needle and may be cracked. Therefore, it is preferable to use within the above range.
  • the voltage intensity, the anodizing process time, NH 4 F concentration, etc. There the adjustable average diameter and an average depth of the hole by controlling the anodizing process condition, the voltage is high, or anodizing treatment time longer or NH 4 F concentration of Increasing the value increases the average diameter of the hole and tends to deepen the average depth.
  • the voltage strength 20V, anodizing time is 30 minutes, anodizing may be performed under conditions of NH 4 F concentration of 0.2% by weight, in this case, voltage strength, anodizing time, NH 4
  • the depth of the hole and / or the size of the hole can be adjusted by decreasing or increasing the F concentration, respectively.
  • the average diameter of the holes formed in the needles subjected to the anodizing process may be 1.5 ⁇ m or less, preferably 0.3 ⁇ m to 1.5 ⁇ m, and more preferably 0.3 ⁇ m to 1.2 ⁇ m.
  • the average depth of the formed holes may be 0.2 ⁇ m to 1 ⁇ m, preferably 0.3 ⁇ m to 0.8 ⁇ m.
  • the needle after anodization may change the needle and components before the anodization process.
  • EDS Electronic Dispersive Spectrometer
  • the components of the saliva are iron (Fe) 24% to 28%, chromium (Cr) 6% to 10%, carbon (C) 61.5% to 66%, nickel (Ni) 1.5% to 3.5% and silicon (Si).
  • porous needle prepared by performing the anodizing treatment in the same manner as described above may be washed with purified water, and then subjected to a sonication process in an acetone-containing solution to prepare a porous resin needle.
  • the porous resin needle of the present invention prepared by the anodization process as described above has 15 to 200 concave-shaped holes, preferably 100 to 100 ⁇ m 2 (width ⁇ length, 10 ⁇ m ⁇ 10 ⁇ m). It may have 180 holes, more preferably 100 to 150 holes.
  • the porous resin needle of the present invention measures the amount of the methylene blue solution buried on the surface of the resin needle, and then, based on the method of calculating the specific surface area, the specific surface area is measured from 4.5 m 2 / g to 12 m 2 / g, Preferably it can have a very high specific surface area of 6.0 m 2 / g to 11.5 m 2 / g, more preferably 10.0 m 2 / g to 11.5 m 2 / g, which doubles the electron transfer function to the nervous system located in the meridians. Treatment efficacy by the procedure can be greatly increased.
  • the resin needle is carried out, thereby directly delivering the drug in the human body, thereby doubling the therapeutic efficacy of the acupuncture.
  • the resin needles on the market were washed with acetone, ethanol, and purified water for 10 minutes each at 40 kHz intensity, and the washed resin needles were on the left side of the photograph of FIG.
  • FIG. 1 After connecting the washed resin needle to the (+) electrode and the carbon electrode to the (-) electrode, the resin needle and the carbon electrode were put into the electrolyte solution, and then DC 20V was applied for 30 minutes.
  • the porous resin needle was prepared by anodizing, and a photograph thereof is shown in FIG. 2 (a), and the right resin needle of FIG. 2 (a) is the porous resin needle after anodizing treatment.
  • the electrolyte solution used was ethylene glycol containing 0.2 wt% of ammonium fluoride (NH 4 F) and 2 wt% of purified water (Etlylene Glycole, C 2 H 4 (OH) 2 ) 50 ml of aqueous solution was used.
  • NH 4 F ammonium fluoride
  • Etlylene Glycole, C 2 H 4 (OH) 2 purified water
  • the component change of the resin needle was measured by measuring the EDS of the resin needle before and after the anodizing treatment used in Example 1, and the results are shown in Table 1 below.
  • the EDS measurement was measured by detecting and analyzing a specific X-ray obtained by emitting a high energy beam of 20k on the needle surface.
  • a porous resin needle was prepared in the same manner as in Example 1, but a voltage was applied at DC 15V for 30 minutes to prepare a porous resin needle, and the SEM measurement thereof was measured in the same manner as in Example 1, and the results are shown in FIG. 4. Indicated.
  • a porous resin needle was prepared in the same manner as in Example 1, but a porous resin needle was prepared by applying a voltage at DC 25V for 30 minutes, and the SEM measurement thereof was measured in the same manner as in Example 1, and the results are shown in FIG. 5. Indicated. Looking at Figure 5, it can be seen that it is well formed, but when compared with Example 1, the hole size was small and the thickness of the needle tended to decrease.
  • a porous resin needle was prepared in the same manner as in Example 1, and a porous resin needle was prepared by applying a voltage at 30V for 30 minutes. And, the SEM measurement thereof was measured in the same manner as in Example 1, the results are shown in Figure 6, it can be seen that the hole is well formed. However, compared with Example 1, the hole size was small and the thickness of the needle tended to decrease.
  • a porous resin needle was prepared in the same manner as in Example 1, but a porous resin needle was prepared by applying a voltage at DC 10V for 30 minutes. And, the SEM measurement thereof was measured in the same manner as in Example 1, the results are shown in Figure 7, it was confirmed that the hole is hardly formed, which results in a low voltage, insufficient to form the hole It is judged by the result of applying the voltage.
  • a porous resin needle was prepared in the same manner as in Example 1, but a porous resin needle was prepared by applying a voltage at DC 40V for 30 minutes.
  • the SEM measurement thereof was measured in the same manner as in Example 1, and the results are shown in FIG. 8, and the resin needles were mostly melted, and it was confirmed that there was a problem that the needle was broken in the middle.
  • the method for obtaining the specific surface area is based on Equation 1 below, by measuring the absorbance of the aqueous methylene blue solution supported on the resin needle before and after anodization to determine the concentration of methylene blue (Concentration), using the following proportional formula 1
  • the specific surface area was measured by substitution.
  • Equation 1 1.667e -5 (M / Abs) is a conversion factor obtained through an absorbance experiment of methylene blue aqueous solution having a known concentration.
  • Concentration 1 is the concentration of methylene blue supported on the resin needle before anodization
  • Concentration 2 is the concentration of methylene blue supported on the resin needle after anodization.
  • the specific surface area before the anodization is 0.0017 (m 2 / g), which is calculated through the thickness, length, and weight of the needle.
  • Example 4 in which the voltage intensity was performed at DC 30V, the number of holes was formed the most, but the specific surface area was lower than 5.0 m 2 / g when compared to Examples 1 to 3.
  • Example 1 which performed anodization at 20V voltage intensity was the highest, and the porous resin needle of Example 2 which performed anodization at 15V voltage intensity also showed high absorbance.
  • Example 4 which was carried out at 30 V voltage intensity, absorbance results were lower than those of Examples 1, 2, and 3.
  • the drug may be supported in the hole of the porous resin needle by dipping the porous resin needle prepared in Example 1 in a methylene blue solution.
  • the weight of the resin needle was 0.1 mg before the dye was loaded, the weight was 0.1007 mg, 0.7% increased after loading the dye, through which the drug effectively It could be confirmed that it is supported.
  • the hole was well formed on the surface of the porous resin needle of the present invention, and it was confirmed that it had a high specific surface area, and it was also confirmed that the drug was well supported in the hole formed on the surface.
  • porous resin needle of the present invention can be achieved a significant therapeutic effect through the resin needle treatment, it is possible to provide a medical resin needle having this effect.

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Abstract

The present invention relates to a porous hand acupuncture needle and a manufacturing method therefor and, more specifically, to a porous hand acupuncture needle and a method for manufacturing the same, the needle of which a specific surface area is maximized by forming micro sized or nano sized holes on the surface of a hand acupuncture needle.

Description

다공성 수지침 및 이의 제조방법Porous Resin Needle and Manufacturing Method Thereof
본 발명은 표면에 마이크로 내지 나노크기의 홀이 다량으로 형성되어 있는 수지침 및 이를 제조하는 방법에 관한 것이다. The present invention relates to a resin needle and a method of manufacturing the same in which a large amount of holes of micro to nano size are formed on a surface thereof.
침은 피부를 투과하도록 만든 장치로서, 일반적으로 강도와 생물학적 안전성이 확인된 금속으로 제작되며, 전통적인 수지침은 도 1에서 도시된 바와 같이, 침첨, 침체 및 침병으로 구성되며, 돌, 금, 은, 구리, 철, 뼈 및 가시와 같은 재질을 사용하여 제조하였다. 최근 기술이 발달함에 따라 침 재질로서 견고하여 잘 부러지지 않고, 부식에 강하며 인체에 해롭지 않은 스테인레스 강 304 또는 316 L 등을 사용하고 있다.Acupuncture is a device made to penetrate the skin, and is generally made of a metal whose strength and biological safety has been confirmed, and a conventional resin needle is composed of acupuncture, stagnation, and acupuncture as shown in FIG. 1, and includes stones, gold, silver, Made using materials such as copper, iron, bone and barbed. With the recent development of technology, stainless steel 304 or 316L is used as a saliva material, which is hard and not easily broken, resistant to corrosion and harmful to humans.
일반적으로 많이 사용되는 주사침의 굵기와 표면 상태에 따라 자침 시 환자가 느끼는 고통이 달라지므로, 기존의 많은 기술들은 환자의 고통 정도를 감소시키는 방향으로 발전하였다. 예를 들어, 자침 시 침과 인체 조직 사이의 마찰을 줄이는 방법으로 침 표면에 실리콘(Silicone) 막을 도포하기도 하였고, 침 표면을 매끄럽게 가공하여 표면 거칠기를 줄여줌으로써 침이 조직으로 침투할 때 생기는 저항을 감소시켜 환자가 느끼는 고통을 감소시켰다. 또한, 침의 굵기가 가늘수록 침 삽입 시 환자의 고통이 줄어들기 때문에 점점 더 가는 침이 제조 및 사용되고 있다.Since the pain felt by the patient depends on the thickness and surface condition of commonly used needles, many existing technologies have been developed to reduce the degree of pain of the patient. For example, a silicone film was applied to the needle surface to reduce friction between the needle and human tissue during needle acupuncture, and the needle surface was smoothed to reduce the surface roughness, thereby reducing the resistance caused when the needle penetrates into the tissue. To reduce the pain the patient feels. In addition, thinner needles are manufactured and used more and more, because the pain of the patient is reduced when the needle is inserted.
주사침(주사용 침)의 사용 목적은 주사침을 통해 혈관 및 근육 등의 신체 조직에 특정 약물을 주입하는 것이며, 주사침을 삽입함으로써 직접적인 치료 효과를 기대하지는 않는다. 그러나, 수지침은 약물의 주입을 목적으로 하지 않고, 침을 경락, 경혈과 같은 특정 부위에 삽입함으로써 치료 효과를 도모한다. 따라서, 조직에 침을 삽입하는 목적에 양자간 근본적인 차이가 존재한다.The purpose of using needles (injection needles) is to inject certain drugs into body tissues such as blood vessels and muscles through needles, and does not expect a direct therapeutic effect by inserting the needles. However, resin needles do not aim to inject drugs, and the needle is inserted into specific sites such as meridians and acupuncture points to achieve a therapeutic effect. Thus, there is a fundamental difference between the purposes of inserting saliva into tissue.
즉, 주사침과는 달리 수지침은 자침 시 침의 신체 조직에 대한 물리적인 자극이 중요하게 여겨진다. 그러나, 침 치료 효과와는 상관없이 자침 시 환자가 느끼는 고통을 줄이려는 목적으로 침 표면을 매끄럽게 하는 일반 주사침의 제조 방법과 유사하게 침을 만들고 있다. 또한 침 표면의 상태에 따라 환자가 느끼는 고통은 줄일 수 있으나, 침 치료 효과가 동일하다는 어떠한 실험결과도 없다.That is, unlike needles, resin needles are considered to have important physical stimulation of body tissues when sleeping. However, regardless of the effect of acupuncture, needles are made in a manner similar to a method of manufacturing a general needle that smoothes the surface of the needle for the purpose of reducing the pain felt by the patient when sleeping. In addition, the pain felt by the patient according to the condition of the surface of the saliva can be reduced, but there is no experimental result that the acupuncture treatment effect is the same.
이와는 대조적으로 침과 조직에 관한 연구에 의하면(H. Langevin, 2002, Faseb) 자침 후, 침을 좌우로 돌림으로써 연결조직(connective tissue)이 침 표면에 감기게 되어, 그 자극으로 인하여 침 치료 효과가 나타난다는 결과가 발표되었다. 이 연구결과는 침 표면과 연결조직 사이의 결합력이 침 치료 효과에 중요하다는 것을 의미한다. 즉, 침 표면의 물성에 변화를 주어 양자 사이의 결합력을 증가시키면 침 치료 효과를 증진시킬 수 있음을 뜻한다. 그러나 지금까지는 수지침 제조 시 침 표면의 거칠기를 줄이는 기술이 적용되어 왔으며, 이는 양자 사이의 결합력을 감소시키는 방향으로만 연구가 진행되었음을 의미한다.In contrast, studies on acupuncture and tissues (H. Langevin, 2002, Faseb) suggest that after turning a needle, the connective tissue is wound around the surface of the needle by turning the needle from side to side. Results appear. The results indicate that the adhesion between the surface of the needle and the connective tissue is important for the effect of acupuncture. That is, by changing the physical properties of the saliva surface to increase the binding between the two means that can improve the effect of acupuncture treatment. However, until now, a technique for reducing the roughness of the needle surface has been applied in manufacturing the needle, which means that the research has been conducted only to reduce the binding force between the two.
한편, 일반적으로 침 제조에 사용되고 있는 침 표면 물성을 변화시키는 기술은 화학물질을 침 표면에 도포하는 것이었다. 이 기술의 목적은 도포 물질에 따라 크게 두 가지로 나눌 수 있는데, 윤활 목적으로 실리콘(silicone) 등과 같은 물질을 도포하는 경우와 항균 및 치료 목적으로 살리실산 같은 물질을 도포하는 경우가 있으나, 이러한 기술들에 의해 제조된 침은 침 표면과 연결조직 사이의 결합력이 감소하게 되는 문제가 있다.On the other hand, a technique for changing the needle surface properties, which are generally used for needle production, was to apply a chemical to the needle surface. The purpose of this technique can be divided into two types according to the application materials, such as the application of materials such as silicone (silicone) for lubrication purposes and the application of salicylic acid for antibacterial and therapeutic purposes, but these techniques The needle produced by this is a problem that the adhesion between the needle surface and the connective tissue is reduced.
한편, 일반 주사침과 수지침의 소재로 주로 사용되는 것은 스테인레스 강 (stainless steel)이며, 그 중에서도ss304 (STS304) 가 많이 사용되는데, 이들은 모두 오스테나이트 계열에 속한다. 이러한 스테인레스강의 표면 거칠기를 줄이는 방법 중에 하나는 전해연마 (electropolishing)이며, 특히 ss304 (STS304)에 잘 적용되는 기술이다. 전해연마는 전해액 내에서 연마하고자 하는 금속에 전기를 가하면 전기분해에 의해 그 금속 표면에 점성이 있는 초기 산화층이 생성되면서 금속산화물의 부동태 피막이 형성되어 상대적으로 굴곡이 있어 튀어나온 면이 더 많이 깎이게 되어 전체적으로 그 금속 표면이 평탄해지는 기술이다. 이 기술을 적용하여 상기의 스테인레스 강의 표면 거칠기를 조정한다.On the other hand, the main needle and resin needles are mainly used for stainless steel, and among them, ss304 (STS304) is used a lot, all of which belong to the austenitic series. One method of reducing the surface roughness of such stainless steels is electropolishing, and is a technique particularly well applied to ss304 (STS304). When electropolishing is applied to the metal to be polished in the electrolytic solution, a viscous initial oxide layer is formed on the surface of the metal by electrolysis, and a passivation film of metal oxide is formed so that the protruding surface is more bent due to the relatively curved surface. It is a technique that the metal surface becomes flat as a whole. This technique is applied to adjust the surface roughness of the stainless steel.
또 다른 기술은 강력한 레이저를 사용하여 표면을 가공하는 기술(laser ablation)로서 강력한 레이저 펄스 빔(pulse beam)을 금속에 입사시켜 표면물질을 순간적으로 융발(ablation)시켜 무늬를 만드는 방법이다. 이때 레이저의 출력을 조절하여 무늬의 깊이를 조절할 수 있다. 현재 이 기술은 금속뿐만 아니라 반도체 제조용 실리콘 기판(wafer)에 마킹(marking)용으로도 사용되고 있다. 한편, 수지침의 표면 처리 방법으로 가장 많이 사용되는 것은 기계적 연마 (grinding)로 침 첨단부를 형성하고 표면 거칠기를 감소시키는 방향으로 개발되어 왔다. 그러나, 이러한 기술은 방향성을 가지는 표면을 형성하기가 힘들다.Another technique is the use of powerful lasers to process the surface (laser ablation), which injects a powerful laser pulse beam into the metal to instantaneously ablate the surface material to form a pattern. At this time, the depth of the pattern can be adjusted by adjusting the output of the laser. The technology is currently used for marking not only metals but also silicon wafers for semiconductor manufacturing. On the other hand, the most widely used method for surface treatment of resin needles has been developed in the direction of forming needle tip and reducing surface roughness by mechanical grinding. However, this technique is difficult to form directional surfaces.
이에 침 표면에 물리적 형태변화를 주어 결합조직과 접하는 침 표면의 유효 면적(effective area)을 확장하여 양자간의 결합력을 향상시킨 수지침을 제조하는 기술(대한민국 공개특허 2008-0112759호)이 있으나, 침 표면의 거칠기로 인하여 피부에 손상을 가할 수 있는 문제가 있다.In this regard, there is a technique for manufacturing a resin needle which improves the binding force between the needle surface by extending the effective area of the needle surface in contact with the connective tissue by changing the physical shape of the needle surface (Korean Patent Publication No. 2008-0112759). There is a problem that can damage the skin due to the roughness of.
본 발명은 기존 수지침의 표면 거칠기로 인한 피부 손상 문제를 방지할 뿐만 아니라, 수지침을 통해 약물을 효과적으로 인체 내에 전달할 수 있는 새로운 수지침 및 이와 같이 수지침을 효과적으로 제조할 수 있는 방법을 제공하고자 한다.The present invention not only prevents skin damage due to the surface roughness of the existing resin needles, but also provides a new resin needle and a method for effectively producing the resin needles that can effectively deliver the drug through the resin needles in the human body.
상술한 과제를 해결하기 위하여 본 발명은 다공성 수지침에 관한 것으로서, 침의 표면 넓이 100㎛2(가로×세로, 10 ㎛×10 ㎛)당 15 ~ 200개의 홀(hole)을 포함하는 것을 특징으로 할 수 있다.In order to solve the above problems, the present invention relates to a porous resin needle, characterized in that it comprises 15 to 200 holes per 100㎛ 2 (width × length, 10 ㎛ × 10 ㎛) of the surface area of the needle Can be.
본 발명의 바람직한 일실시예로서, 본 발명의 다공성 수지침에 있어서, 상기 홀은 평균지름이 0.3㎛ ~ 1.5㎛이고, 상기 홀은 평균깊이가 0.2㎛ ~ 1㎛인 것을 특징으로 할 수 있다.As a preferred embodiment of the present invention, in the porous resin needle of the present invention, the holes may have an average diameter of 0.3 μm to 1.5 μm, and the holes may have an average depth of 0.2 μm to 1 μm.
본 발명의 바람직한 일실시예로서, 본 발명의 다공성 수지침은 상기 홀에 약물이 담지된 것을 특징으로 할 수 있다.As a preferred embodiment of the present invention, the porous resin needle of the present invention may be characterized in that the drug is supported in the hole.
본 발명의 바람직한 일실시예로서, 본 발명의 다공성 수지침은 수지침의 표면에 묻어난 메틸렌 블루 용액의 양을 측정한 뒤 비표면적을 계산해 내는 방법에 의거하여 측정 시, 비표면적 9.0 ㎡/g 이상, 바람직하게는 비표면적 10.0 ㎡/g ~ 11.5 ㎡/g 인 것을 특징으로 할 수 있다.As a preferred embodiment of the present invention, the porous resin needle of the present invention is measured on the basis of the method of calculating the specific surface area after measuring the amount of methylene blue solution buried on the surface of the resin needle, the specific surface area of 9.0 m 2 / g or more, preferably Preferably, the specific surface area may be 10.0 m 2 / g to 11.5 m 2 / g.
본 발명의 바람직한 일실시예로서, 본 발명의 다공성 수지침은 철(Fe) 24% ~ 28%, 크롬(Cr) 6% ~ 10%, 탄소(C) 61.5% ~ 66%, 니켈(Ni) 1.5% ~ 3.5% 및 실리콘(Si) 0.1% ~ 0.5%를, 바람직하게는 철(Fe) 25% ~ 27%, 크롬(Cr) 7% ~ 9%, 탄소(C) 62% ~ 64%, 니켈(Ni) 2% ~ 3% 및 실리콘(Si) 0.2% ~ 0.3%를 포함하는 것을 특징으로 할 수 있다.As a preferred embodiment of the present invention, the porous resin needle of the present invention is iron (Fe) 24% ~ 28%, chromium (Cr) 6% ~ 10%, carbon (C) 61.5% ~ 66%, nickel (Ni) 1.5 % To 3.5% and silicon (Si) 0.1% to 0.5%, preferably 25% to 27% iron (Fe), 7% to 9% chromium (Cr), 62% to 64% carbon (C) (Ni) 2% to 3% and silicon (Si) may be characterized in that it comprises 0.2% to 0.3%.
본 발명의 다른 태양은 앞서 설명한 본 발명의 다공성 수지침을 제조하는 방법에 관한 것으로서, 침을 양극산화처리공정을 수행하여 침의 표면에 다공성 구조를 형성시켜서 다공성 수지침을 제조하는 것을 특징으로 할 수 있다.Another aspect of the present invention relates to a method for manufacturing the porous resin needle of the present invention described above, it may be characterized in that to produce a porous resin needle by forming a porous structure on the surface of the needle by performing anodizing process of the needle. .
본 발명의 바람직한 일실시예로서, 상기 양극산화처리 공정 전에 침을 세척하는 공정을 수행할 수 있으며, 상기 세척하는 공정은 양극산화처리 공정 전의 침을 아세톤에서 초음파 처리(sonication)한 후, 에탄올에서 초음파 처리한 다음, 정제수 내에서 다시 초음파 처리하여 수행할 수 있다. As a preferred embodiment of the present invention, a step of washing the saliva may be performed before the anodizing process, and the washing process may be performed by treating the saliva before anodizing with sonication in acetone, and then in ethanol. After sonication, it may be performed by sonication again in purified water.
본 발명의 바람직한 일실시예로서, 상기 양극산화처리공정은 상기 침 및 탄소전극을 포함하는 전해액 내에 수행하고, 상기 침은 (+)극으로서 사용하고, 상기 탄소전극은 (-)극으로서 사용하며, 10분 ~ 1시간 동안 12V ~ 30V 의 직류를 가하여 수행하는 것을 특징으로 할 수 있다.In a preferred embodiment of the present invention, the anodizing process is carried out in an electrolyte containing the needle and the carbon electrode, the needle is used as a (+) electrode, the carbon electrode is used as a (-) electrode For example, it may be performed by applying a DC of 12V to 30V for 10 minutes to 1 hour.
본 발명의 다른 바람직한 일실시예로서, 본 발명의 제조방법에 있어서, 상기 전해액은 에틸렌 글라이콜 수용액, 및 글리세롤 수용액 중에서 선택된 1종 이상을 포함하는 것을 특징으로 할 수 있다.In another preferred embodiment of the present invention, in the preparation method of the present invention, the electrolyte may be characterized in that it comprises one or more selected from aqueous solution of ethylene glycol, and aqueous solution of glycerol.
본 발명의 다른 바람직한 일실시예로서, 본 발명의 제조방법에 있어서, 상기 전해액은 플루오린화 암모늄 0.1 ~ 0.5 중량% 및 물 1 ~ 5중량%를, 바람직하게는 플루오린화 암모늄 0.1 ~ 0.3 중량% 및 물 1 ~ 3중량%를 함유한 에틸렌 글라이콜 수용액인 것을 특징으로 할 수 있다. In another preferred embodiment of the present invention, in the preparation method of the present invention, the electrolyte is 0.1 to 0.5% by weight of ammonium fluoride and 1 to 5% by weight of water, preferably 0.1 to 0.3% by weight of ammonium fluoride, and It may be characterized in that the aqueous solution of ethylene glycol containing 1-3% by weight of water.
본 발명의 다른 바람직한 일실시예로서, 본 발명의 제조방법에 있어서, 상기 양극산화처리공정 전의 침은 EDS(Energy Dispersive Spectometer) 측정시, 철(Fe) 37% ~ 42.5%, 크롬(Cr) 9.5% ~ 15%, 탄소(C) 39% ~ 45%, 니켈(Ni) 2.5% ~ 6% 및 실리콘(Si) 0.3% ~ 0.8%를, 바람직하게는 철(Fe) 38% ~ 42%, 크롬(Cr) 10% ~ 14%, 탄소(C) 40% ~ 44%, 니켈(Ni) 3% ~ 5% 및 실리콘(Si) 0.3% ~ 0.6%를 포함하는 것을 특징으로 할 수 있다.In another preferred embodiment of the present invention, in the manufacturing method of the present invention, the needle before the anodizing step is 37% to 42.5% of iron (Fe), chromium (Cr) 9.5 when measuring EDS (Energy Dispersive Spectometer) % To 15%, carbon (C) 39% to 45%, nickel (Ni) 2.5% to 6% and silicon (Si) 0.3% to 0.8%, preferably iron (Fe) 38% to 42%, chromium (Cr) 10% to 14%, carbon (C) 40% to 44%, nickel (Ni) 3% to 5% and silicon (Si) may be characterized in that it comprises 0.3% to 0.6%.
본 발명의 다른 바람직한 일실시예로서, 본 발명의 제조방법에 있어서, 상기 양극산화처리공정 후의 다공성 수지침은 EDS(Energy Dispersive Spectometer) 측정시, 철(Fe) 24% ~ 28%, 크롬(Cr) 6% ~ 10%, 탄소(C) 61.5% ~ 66%, 니켈(Ni) 1.5% ~ 3.5% 및 실리콘(Si) 0.1% ~ 0.5%를, 바람직하게는 철(Fe) 25% ~ 27%, 크롬(Cr) 7% ~ 9%, 탄소(C) 62% ~ 64%, 니켈(Ni) 2% ~ 3% 및 실리콘(Si) 0.2% ~ 0.3%를 포함하는 것을 특징으로 할 수 있다.In another preferred embodiment of the present invention, in the manufacturing method of the present invention, the porous resin needle after the anodizing process, iron (Fe) 24% ~ 28%, chromium (Cr) when measuring EDS (Energy Dispersive Spectometer) 6% to 10%, carbon (C) 61.5% to 66%, nickel (Ni) 1.5% to 3.5% and silicon (Si) 0.1% to 0.5%, preferably iron (Fe) 25% to 27%, 7% to 9% of chromium (Cr), 62% to 64% of carbon (C), 2% to 3% of nickel (Ni), and 0.2% to 0.3% of silicon (Si).
본 발명의 수지침은 기존 수지침과 같이 침의 외부로 도출되는 형태가 아닌 내부로 함몰된 형태의 홀이 형성되어 있는 바, 피부 손상 문제가 없을 뿐만 아니라, 침의 표면에 다수의 마이크로 크기 내지 나노 크기를 갖는 홀이 균일하게 형성되어 있어서, 표면적이 획기적으로 증가되었는 바, 침에 의한 생리학적 치료 효과를 증대시킬 수 있다. 또한, 침의 표면에 형성된 홀에 약물을 담지시켜서 인체 내에 투입할 수 있기 때문에 침에 의한 효과를 극대화시킬 수 있다.Since the resin needle of the present invention is formed with a hole in the form recessed inward rather than a shape derived from the outside of the needle like a conventional resin needle, there is no problem of skin damage, and a plurality of micro size to nano size on the surface of the needle Since the hole having is uniformly formed, the surface area is significantly increased, and thus the physiological treatment effect by saliva can be increased. In addition, since the drug can be added to the human body by supporting the drug formed in the hole formed on the surface of the saliva can maximize the effect by the saliva.
도 1은 본 발명의 다공성 수지침을 양극산화 법에 의해 제조하는 일례로서, 제조하는 방법에 대한 개략도이다.1 is a schematic diagram of a method for producing the porous resin needle of the present invention by an anodizing method.
도 2는 양극산화처리 전후의 수지침의 표면에 대한 SEM 측정사진으로서, 도 2의(a)의 왼쪽 수지침은 양극산화처리 전의 수지침 사진이고, 도 2의(a)의 오른쪽 수지침은 양극산화처리 후의 다공성 수지침이다. 그리고, 도 2의(b)는 양극산화처리 전의 수지침의 표면에 대한 SEM 측정 사진이고, 도 2의 (c) 및 도2의 (d)는 양극산화처리 후의 수지침의 표면에 대한 SEM 측정 사진이다.FIG. 2 is a SEM measurement photograph of the surface of the resin needle before and after anodization treatment. The left resin needle of FIG. 2 (a) is a photograph of the resin needle before anodization treatment, and the right resin needle of FIG. It is a porous resin needle. 2B is a SEM photograph of the surface of the resin needle before anodizing, and FIGS. 2C and 2D are SEM photographs of the surface of the resin needle after anodizing. .
도 3은 실험예 1에서 실시한 실시예 1의 양극산화처리 후의 수지침의 표면을 확대하여 측정한 SEM 측정 사진이다.FIG. 3 is an SEM measurement photograph obtained by enlarging and measuring the surface of the resin needle after the anodizing treatment of Example 1 performed in Experimental Example 1. FIG.
도 4는 실시예 2에서 제조한 양극산화처리 후의 수지침의 표면을 확대하여 측정한 SEM 측정 사진이다.FIG. 4 is an SEM measurement photograph obtained by enlarging and measuring the surface of the resin needle after anodizing prepared in Example 2. FIG.
도 5는 실시예 3에서 제조한 양극산화처리 후의 수지침의 표면을 확대하여 측정한 SEM 측정 사진이다.FIG. 5 is an SEM measurement photograph obtained by enlarging and measuring the surface of the resin needle after the anodization treatment prepared in Example 3. FIG.
도 6은 실시예 4에서 제조한 양극산화처리 후의 수지침의 표면을 확대하여 측정한 SEM 측정 사진이다.FIG. 6 is an SEM measurement photograph obtained by enlarging and measuring the surface of the resin needle after the anodization treatment prepared in Example 4. FIG.
도 7은 비교예 1에서 제조한 양극산화처리 후의 수지침의 표면을 확대하여 측정한 SEM 측정 사진이다.FIG. 7 is an SEM measurement photograph obtained by enlarging and measuring the surface of the resin needle after anodizing prepared in Comparative Example 1. FIG.
도 8은 비교예 2에서 제조한 양극산화처리 후의 수지침의 표면을 확대하여 측정한 SEM 측정 사진이다.FIG. 8 is an SEM measurement photograph obtained by enlarging and measuring the surface of the resin needle after anodizing prepared in Comparative Example 2. FIG.
본 발명에서 사용하는 용어인 홀(hole)은 침의 표면 방향에서 침의 내부 방향으로 오목한 형상으로 형성된 구멍을 의미한다.The term "hole" used in the present invention means a hole formed in a concave shape in the direction of the needle in the surface direction of the needle.
이하, 본 발명을 보다 상세하게 설명한다.Hereinafter, the present invention will be described in more detail.
본 발명의 수지침은 침의 표면에 다공성을 형성된 수지침에 관한 것으로서, 양극산화처리공정을 수행하여 침의 표면에 미세크기의, 나노크기의 홀을 형성시켜서 제조할 수 있다. The resin needle of the present invention relates to a resin needle having a porosity formed on the surface of the needle, and may be prepared by forming an nano-sized hole on the surface of the needle by performing an anodizing process.
그리고, 양극산화처리공정 전의 침은 세척공정을 수행한 후에 사용할 수 있으며, 이때, 세척공정은 침의 표면에 이물질 등을 제거하기 위한 것으로서, 당업계에서 일반적인 방법을 사용할 수 있으며, 바람직하게는 침을 아세톤에서 초음파 처리(sonication)한 후, 에탄올에서 초음파 처리한 다음, 이를 다시 정제수 내에서 다시 초음파 처리하여 수행할 수 있다. 이때, 각각의 상기 초음파 처리 시간은 특별히 한정하지는 않으나, 5분 ~ 20분 정도가 적절하다.In addition, the needle before the anodizing process may be used after performing the washing process, wherein the washing process is to remove foreign substances, etc. on the surface of the needle, it is possible to use a general method in the art, preferably After sonication in acetone, and then sonicated in ethanol, it can be carried out again by sonication in purified water again. At this time, each of the ultrasonic treatment time is not particularly limited, but 5 minutes to 20 minutes are appropriate.
그리고, 상기 양극산화처리공정 전의 침은 일반적으로 판매되고 있는 침을 사용할 수 있으며, 바람직하게는 EDS(Energy Dispersive Spectometer) 측정시, 철(Fe) 37% ~ 42.5%, 크롬(Cr) 9.5% ~ 15%, 탄소(C) 39% ~ 45%, 니켈(Ni) 2.5% ~ 6% 및 실리콘(Si) 0.3% ~ 0.8%를 포함하는 침을, 더욱 바람직하게는 철(Fe) 38% ~ 42%, 크롬(Cr) 10% ~ 14%, 탄소(C) 40% ~ 44%, 니켈(Ni) 3% ~ 5% 및 실리콘(Si) 0.3% ~ 0.6%를 포함하는 침을 사용할 수 있다.In addition, the needle before the anodizing process may use a needle that is generally sold, preferably 37% to 42.5% of iron (Fe), 9.5% to chromium (Cr) when measuring EDS (Energy Dispersive Spectometer) 15%, 39% to 45% of carbon (C), 2.5% to 6% of nickel (Ni) and 0.3% to 0.8% of silicon (Si), more preferably 38% to 42 of iron (Fe) A needle containing%, chromium (Cr) 10% to 14%, carbon (C) 40% to 44%, nickel (Ni) 3% to 5% and silicon (Si) 0.3% to 0.6% may be used.
또한, 상기 양극산화처리공정은 침을 (+)극에, 그리고 탄소전극을 (-)극에 연결한 후에 침과 탄소전극을 전해액에 담근 후, 직류(DC) 12V ~ 30V의 전압을, 바람직하게는 12V ~ 28V의 전압을, 더욱 바람직하게는 15V ~ 26V의 전압을 10분 ~ 1시간 동안, 바람직하게는 20분 ~ 40분 동안 가하여 침의 표면에 도 2와 같은 표면에 마이크로 크기 ~ 나노 크기의 홀을 형성시킬 수 있다. 상기 전압이 12V 미만이면, 수지침의 표면에 홀이 생기지 못하는 문제가 있을 수 있고, 30V를 초과하면 수지침이 산화되어 끊어지는 문제가 있을 수 있으므로, 상기 범위 내의 전압을 가하는 것이 바람직하다. In addition, in the anodizing process, after the needle is connected to the positive electrode and the carbon electrode is connected to the negative electrode, the needle and the carbon electrode are immersed in an electrolyte, and a DC voltage of 12 V to 30 V is preferable. Preferably, a voltage of 12V to 28V, more preferably a voltage of 15V to 26V is applied for 10 minutes to 1 hour, preferably 20 minutes to 40 minutes, and the micro size to nano surface of the needle as shown in FIG. It is possible to form holes of size. If the voltage is less than 12V, there may be a problem that the hole does not occur on the surface of the resin needle, and if it exceeds 30V, there may be a problem that the resin needle is oxidized and broken, it is preferable to apply a voltage within the above range.
본 발명에 있어서, 양극산화처리공정시 사용하는 상기 전해액은 당업계에서 양극산화공정에 사용되는 전해액을 사용할 수 있으나, 바람직하게는 에틸렌 글라이콜(Ethylene glycol) 수용액 및 글리세롤 수용액 중에서 선택된 1종 이상을 포함하는 전해액을 사용하는 것이 좋다. 구체적인 예를 들면, 플루오린화 암모늄(Ammonium Fluoride, NH4F) 0.1 ~ 0.5 중량%, 물 1 ~ 5 중량% 및 잔량의 에틸렌 글라이콜을 함유한 에틸렌 글라이콜 수용액을, 바람직하게는 플루오린화 암모늄 0.1 ~ 0.3 중량%, 물 1 ~ 3중량% 및 잔량의 에틸렌 글라이콜을 함유한 에틸렌 글라이콜 수용액을, 더욱 바람직하게는 플루오린화 암모늄 0.15 ~ 0.25 중량%, 물 1.5 ~ 2.5중량% 및 잔량의 에틸렌 글라이콜을 함유한 에틸렌 글라이콜 수용액을 사용할 수 있다. In the present invention, the electrolyte solution used in the anodizing process may be used an electrolyte solution used in the anodizing process in the art, preferably at least one selected from an aqueous solution of ethylene glycol and an aqueous solution of glycerol It is good to use an electrolyte containing. For example, an aqueous solution of ethylene glycol containing 0.1 to 0.5% by weight of ammonium fluoride (NH 4 F), 1 to 5% by weight of water and the remaining amount of ethylene glycol, preferably fluorinated An aqueous solution of ethylene glycol containing 0.1 to 0.3% by weight of ammonium, 1 to 3% by weight of water and the remaining amount of ethylene glycol, more preferably 0.15 to 0.25% by weight of ammonium fluoride, 1.5 to 2.5% by weight of water, and Ethylene glycol aqueous solution containing the residual amount of ethylene glycol can be used.
상기 에틸렌 글라이콜 수용액에 있어서, 상기 플루오린화 암모늄(NH4F)은 수지침의 산화된 성분과 결합하여 성분이 수용액 쪽으로 녹아내는 역할을 하는 것으로서, 0.1 ~ 0.5 중량%, 바람직하게는 0.1 ~ 0.3 중량%, 더욱 바람직하게는 0.2 ~ 0.25 중량%를 함유하도록 사용하는 것이 좋은데, 이때, 그 함유량이 0.1 중량% 미만이면 수지침 표면에 생성되는 홀의 수가 줄어들고, 평균 깊이와 크기가 작아지는 문제가 있을 수 있고, 함유량이 0.5 중량%를 초과하면 수지침의 표면에 홀이 생성되지 못하고 갈라지는 문제가 있을 수 있으므로, 상기 범위 내로 사용하는 것이 좋다.In the aqueous solution of ethylene glycol, the ammonium fluoride (NH 4 F) is combined with the oxidized component of the resin needle to play a role of melting the component toward the aqueous solution, 0.1 to 0.5% by weight, preferably 0.1 to 0.3 It is preferable to use it so as to contain a weight%, more preferably 0.2 to 0.25 weight%, if the content is less than 0.1 weight%, the number of holes formed on the surface of the resin needle is reduced, there may be a problem that the average depth and size decreases If the content is more than 0.5% by weight, holes may not be formed on the surface of the resin needle and may be cracked. Therefore, it is preferable to use within the above range.
앞서 설명한 전압세기, 양극산화처리 시간, NH4F 농도 등의 양극산화처리 조건을 조절하여 홀의 평균지름 및 평균 깊이를 조절할 수 있는데, 전압이 높이거나, 양극산화처리 시간 길거나 또는 NH4F의 농도를 증가시키면 홀의 평균지름이 커지고, 평균 깊이가 깊어지는 경향이 있다. 바람직한 일실시예를 들면, 전압 세기 20V, 양극산화처리 시간은 30분, NH4F 농도 0.2 중량%의 조건 하에서 양극산화처리를 수행할 수 있으며, 이때, 전압세기, 양극산화처리 시간, NH4F 농도를 각각 감소시키거나, 증가시켜서 홀의 깊이 및/또는 홀의 크기를 조절할 수 있다. Above the voltage intensity, the anodizing process time, NH 4 F concentration, etc. There the adjustable average diameter and an average depth of the hole by controlling the anodizing process condition, the voltage is high, or anodizing treatment time longer or NH 4 F concentration of Increasing the value increases the average diameter of the hole and tends to deepen the average depth. For example, the voltage strength 20V, anodizing time is 30 minutes, anodizing may be performed under conditions of NH 4 F concentration of 0.2% by weight, in this case, voltage strength, anodizing time, NH 4 The depth of the hole and / or the size of the hole can be adjusted by decreasing or increasing the F concentration, respectively.
이와 같이 양극산화처리공정을 수행한 침에 형성된 홀의 평균지름은 1.5㎛ 이하, 바람직하게는 0.3㎛ ~ 1.5㎛, 더욱 바람직하게는 0.3㎛ ~ 1.2㎛일 수 있다. 그리고, 형성된 홀의 평균 깊이는 0.2㎛ ~ 1㎛, 바람직하게는 0.3㎛ ~ 0.8㎛일 수 있다.As such, the average diameter of the holes formed in the needles subjected to the anodizing process may be 1.5 μm or less, preferably 0.3 μm to 1.5 μm, and more preferably 0.3 μm to 1.2 μm. The average depth of the formed holes may be 0.2 μm to 1 μm, preferably 0.3 μm to 0.8 μm.
양극산화처리공정 후의 침은 양극산화처리공정 전의 침과 성분이 변화될 수 있으며, 예를 들면 양극산화처리공정 전의 앞서 설명한 성분을 갖는 침을 양극산화처리공정 처리를 하면, EDS(Energy Dispersive Spectrometer) 측정 시, 침의 성분이 철(Fe) 24% ~ 28%, 크롬(Cr) 6% ~ 10%, 탄소(C) 61.5% ~ 66%, 니켈(Ni) 1.5% ~ 3.5% 및 실리콘(Si) 0.1% ~ 0.5%으로, 바람직하게는 철(Fe) 25% ~ 27%, 크롬(Cr) 7% ~ 9%, 탄소(C) 62% ~ 64%, 니켈(Ni) 2% ~ 3% 및 실리콘(Si) 0.2% ~ 0.3%으로 수지침의 성분에 큰 변화가 있음을 확인할 수 있다.The needle after anodization may change the needle and components before the anodization process. For example, when the needle having the above-described components before the anodization process is subjected to anodization, EDS (Energy Dispersive Spectrometer) In the measurement, the components of the saliva are iron (Fe) 24% to 28%, chromium (Cr) 6% to 10%, carbon (C) 61.5% to 66%, nickel (Ni) 1.5% to 3.5% and silicon (Si). ) 0.1% to 0.5%, preferably iron (Fe) 25% to 27%, chromium (Cr) 7% to 9%, carbon (C) 62% to 64%, nickel (Ni) 2% to 3% And it can be seen that there is a large change in the components of the resin needle (Si) 0.2% ~ 0.3%.
그리고, 상기와 같은 방법으로 양극산화처리공정을 수행하여 제조한 다공성 침을 정수된 물에 세척한 뒤, 아세톤 함유 용액에서 초음파 처리(sonication)하는 공정을 더 수행하여 다공성 수지침을 제조할 수도 있다.In addition, the porous needle prepared by performing the anodizing treatment in the same manner as described above may be washed with purified water, and then subjected to a sonication process in an acetone-containing solution to prepare a porous resin needle.
이와 같이 양극산화공정을 통해 제조한 본 발명의 다공성 수지침은 표면 넓이 100㎛2(가로×세로, 10 ㎛×10 ㎛)당 15 ~ 200개의 오목한 형태의 홀(hole)을, 바람직하게는 100 ~ 180개의 홀을, 더욱 바람직하게는 100 ~ 150 개의 홀을 가질 수 있다. 그리고, 본 발명의 다공성 수지침은 이와 같은 수지침의 표면에 묻어난 메틸렌 블루 용액의 양을 측정한 뒤, 비표면적을 계산해 내는 방법에 의거하여 측정시, 비표면적 4.5 ㎡/g ~ 12 ㎡/g을, 바람직하게는 6.0 ㎡/g ~ 11.5 ㎡/g을, 더욱 바람직하게는 10.0 ㎡/g ~ 11.5 ㎡/g의 매우 높은 비표면적을 가질 수 있는 바, 경락에 위치한 신경계에 전자 전달 기능을 배가시켜서 침 시술에 의한 치료 효능을 크게 증가시킬 수 있다.The porous resin needle of the present invention prepared by the anodization process as described above has 15 to 200 concave-shaped holes, preferably 100 to 100 μm 2 (width × length, 10 μm × 10 μm). It may have 180 holes, more preferably 100 to 150 holes. The porous resin needle of the present invention measures the amount of the methylene blue solution buried on the surface of the resin needle, and then, based on the method of calculating the specific surface area, the specific surface area is measured from 4.5 m 2 / g to 12 m 2 / g, Preferably it can have a very high specific surface area of 6.0 m 2 / g to 11.5 m 2 / g, more preferably 10.0 m 2 / g to 11.5 m 2 / g, which doubles the electron transfer function to the nervous system located in the meridians. Treatment efficacy by the procedure can be greatly increased.
또한, 본 발명의 다공성 수지침에 형성되어 있는 홀의 내부에 약물을 담지시켜서 수지침을 시술하여, 인체 내에 약물을 직접적으로 전달함으로써, 침 시술에 의한 치료 효능을 배가시킬 수도 있다.In addition, by carrying the drug in the hole formed in the porous resin needle of the present invention, the resin needle is carried out, thereby directly delivering the drug in the human body, thereby doubling the therapeutic efficacy of the acupuncture.
이하에서는 실시예를 통하여 본 발명을 더욱 구체적으로 설명하기로 하지만, 하기 실시예가 본 발명의 범위를 제한하는 것은 아니며, 이는 본 발명의 이해를 돕기 위한 것으로 해석되어야 할 것이다.Hereinafter, the present invention will be described in more detail with reference to Examples, but the following Examples are not intended to limit the scope of the present invention, which should be construed as to help the understanding of the present invention.
[실시예] EXAMPLE
실시예 1Example 1
동방침구제작소에서 시판 중인 수지침을 아세톤, 에탄올, 정제수에 각각 10분씩, 40 kHz의 세기로 초음파 처리하여 세척을 하였으며, 세척한 수지침은 도 2의 (a)의 사진 왼쪽에 있는 것이다. The resin needles on the market were washed with acetone, ethanol, and purified water for 10 minutes each at 40 kHz intensity, and the washed resin needles were on the left side of the photograph of FIG.
다음으로, 도 1에 나타낸 것과 같이, 상기 세척한 수지침을 (+)극에, 탄소 전극을 (-)극에 연결한 후에, 수지침과 탄소전극을 전해액에 넣은 후, DC 20V를 30분 동안 가하는 양극산화처리하여 다공성 수지침을 제조하였으며, 이의 사진을 도 2의 (a)에 나타내었고, 도 2의 (a)의 오른쪽 수지침이 양극산화처리 후의 다공성 수지침이다.Next, as shown in FIG. 1, after connecting the washed resin needle to the (+) electrode and the carbon electrode to the (-) electrode, the resin needle and the carbon electrode were put into the electrolyte solution, and then DC 20V was applied for 30 minutes. The porous resin needle was prepared by anodizing, and a photograph thereof is shown in FIG. 2 (a), and the right resin needle of FIG. 2 (a) is the porous resin needle after anodizing treatment.
이때, 양극산화처리시, 사용된 전해액은 플루오린화 암모늄(Ammonium Fluoride, NH4F) 0.2 중량% 및 정제수 2 중량%를 함유한 에틸렌 글라이콜(Etlylene Glycole, C2H4(OH)2) 수용액 50 ㎖를 사용하였다. At this time, during the anodization, the electrolyte solution used was ethylene glycol containing 0.2 wt% of ammonium fluoride (NH 4 F) and 2 wt% of purified water (Etlylene Glycole, C 2 H 4 (OH) 2 ) 50 ml of aqueous solution was used.
실험예 1 : SEM (scanning electron microscope)측정Experimental Example 1 SEM (scanning electron microscope) measurement
상기 실시예 1에서 사용한 양극산화처리 전의 수지침의 SEM(상품명 S-4800, 제조사 Hitachi) 측정 사진을 도 2의 (b)에 나타내었고, 실시예 1에서 제조한 다공성 수지침의 표면에 대한 SEM 측정 사진을 도 2의 (c), 도 2의 (d), 및 도 3에 나타내었다.SEM (brand name S-4800, manufacturer Hitachi) measurement photo of the resin needle before the anodization treatment used in Example 1 is shown in Figure 2 (b), SEM measurement photo of the surface of the porous resin needle prepared in Example 1 Are shown in (c) of FIG. 2, (d) of FIG. 2, and FIG.
도 2의 (b)와 (c), (d)의 SEM 측정 사진을 비교해보면, 양극산화처리 전의 수지침(도 2의 (b))은 매끈한 표면을 갖고 있었으나, 이를 양극산화처리한 후에는 3,000 nm 크기 이하의 홀이 다량 형성되어 있는 것을 확인할 수 있었다.Comparing the SEM measurements of FIGS. 2 (b), 2 (c) and 2 (d), the resin needle before the anodization treatment (FIG. 2 (b)) had a smooth surface. It was confirmed that a large amount of holes smaller than the nm size were formed.
그리고, 도 2의 (d)을 살펴보면, 표면 넓이 100㎛2(가로×세로, 10 ㎛×10 ㎛)당 100 개 이상의 홀이 형성된 것을 확인할 수 있었다. 2 (d), it was confirmed that 100 or more holes were formed per surface area of 100 μm 2 (width × length, 10 μm × 10 μm).
또한, 도 3을 살펴보면, 홀의 깊이가 0.35㎛ 정도로 형성된 것을 확인할 수 있었다.In addition, looking at Figure 3, it was confirmed that the depth of the hole is formed about 0.35㎛.
실험예 2 : EDS(Energy Dispersive Spectrometer) 측정Experimental Example 2 Measurement of Energy Dispersive Spectrometer (EDS)
상기 실시예 1에서 사용한 양극산화처리 전후의 수지침에 대한 EDS 측정을 통해 수지침의 성분 변화를 측정하였고 그 결과를 하기 표 1에 나타내었다.The component change of the resin needle was measured by measuring the EDS of the resin needle before and after the anodizing treatment used in Example 1, and the results are shown in Table 1 below.
이때, EDS 측정은 20k의 고에너지 빔을 침 표면에 방출하여 얻어진 특정 X-ray를 검출·분석하여 측정하였다.At this time, the EDS measurement was measured by detecting and analyzing a specific X-ray obtained by emitting a high energy beam of 20k on the needle surface.
표 1
구분 양극산화 처리 전의 수지침 양극산화 처리 후의 수지침
성분 Atom. C (at. %) Error(%) Atom. C (at. %) Error(%)
Fe 40.46 1.69 26.03 1.39
Cr 12.00 0.51 8.01 0.44
C 42.71 3.06 63.24 4.70
Ni 4.32 0.28 2.46 0.22
Si 0.51 0.06 0.25 0.05
Table 1
division Resin Needle before Anodization Resin Needle after Anodization
ingredient Atom. C (at.%) Error (%) Atom. C (at.%) Error (%)
Fe 40.46 1.69 26.03 1.39
Cr 12.00 0.51 8.01 0.44
C 42.71 3.06 63.24 4.70
Ni 4.32 0.28 2.46 0.22
Si 0.51 0.06 0.25 0.05
상기 표 1의 EDS 측정 결과를 살펴보면, 양극산화처리 공정 전, 후로 수지침의 성분에 변화가 있는 것을 확인할 수 있는데, 특히 탄소(C)의 성분이 많아진 걸 볼 수 있다. 이는 다공성 수지침 세척 시 사용하는 용매의 성분이 대부분 유기 용매로 탄소를 많이 포함하는데 성분에서 탄소를 제외하고 성분비교를 해보면 철, 크롬, 니켈, 실리콘의 경우 EDS 특성상 발생하는 오차범위를 감안했을 때 양극산화 전과 후의 수지침 내 성분들 간의 성분비 변화가 거의 없음을 확인할 수 있었다.Looking at the EDS measurement results of Table 1, it can be seen that there is a change in the components of the resin needle before and after the anodizing process, in particular, it can be seen that the components of carbon (C) increased. This is because most of the components of the solvent used to wash porous resin needles contain a lot of carbon as organic solvents.If you compare the components except carbon in the components, the anode, iron, chromium, nickel and silicon, considering the error range that occurs due to EDS characteristics It was confirmed that there is almost no change in the component ratio between the components in the resin needle before and after oxidation.
실시예 2Example 2
상기 실시예 1과 동일한 방법으로 다공성 수지침을 제조하되, 전압을 DC 15V로 30분 동안 가하여 다공성 수지침을 제조하였으며, 이의 SEM 측정을 상기 실시예 1과 동일한 방법으로 측정하였고, 그 결과를 도 4에 나타내었다.A porous resin needle was prepared in the same manner as in Example 1, but a voltage was applied at DC 15V for 30 minutes to prepare a porous resin needle, and the SEM measurement thereof was measured in the same manner as in Example 1, and the results are shown in FIG. 4. Indicated.
도 4를 살펴보면, 홀이 잘 형성되어 있는 것을 확인할 수 있는데, 다만, 실시예 1과 비교할 때, 홀의 크기가 큰 경향이 있었다.Looking at Figure 4, it can be seen that the hole is well formed, but when compared with Example 1, the size of the hole tended to be large.
실시예 3Example 3
상기 실시예 1과 동일한 방법으로 다공성 수지침을 제조하되, 전압을 DC 25V로 30분 동안 가하여 다공성 수지침을 제조하였으며, 이의 SEM 측정을 상기 실시예 1과 동일한 방법으로 측정하였고, 그 결과를 도 5에 나타내었다. 도 5를 살펴보면, 잘 형성되어 있는 것을 확인할 수 있는데, 다만, 실시예 1과 비교할 때, 홀의 크기가 작고 침의 두께가 줄어드는 경향이 있었다.A porous resin needle was prepared in the same manner as in Example 1, but a porous resin needle was prepared by applying a voltage at DC 25V for 30 minutes, and the SEM measurement thereof was measured in the same manner as in Example 1, and the results are shown in FIG. 5. Indicated. Looking at Figure 5, it can be seen that it is well formed, but when compared with Example 1, the hole size was small and the thickness of the needle tended to decrease.
실시예 4Example 4
상기 실시예 1과 동일한 방법으로 다공성 수지침을 제조하였으며, 전압을 30V로 30분 동안 가하여 다공성 수지침을 제조하였다. 그리고, 이의 SEM 측정을 상기 실시예 1과 동일한 방법으로 측정하였고, 그 결과를 도 6에 나타내었으며, 홀이 잘 형성되어 있는 것을 확인할 수 있다. 다만, 실시예 1과 비교할 때, 홀의 크기가 작고 침의 두께가 줄어드는 경향이 있었다.A porous resin needle was prepared in the same manner as in Example 1, and a porous resin needle was prepared by applying a voltage at 30V for 30 minutes. And, the SEM measurement thereof was measured in the same manner as in Example 1, the results are shown in Figure 6, it can be seen that the hole is well formed. However, compared with Example 1, the hole size was small and the thickness of the needle tended to decrease.
비교예 1Comparative Example 1
상기 실시예 1과 동일한 방법으로 다공성 수지침을 제조하되, 전압을 DC 10V로 30분 동안 가하여 다공성 수지침을 제조하였다. 그리고, 이의 SEM 측정을 상기 실시예 1과 동일한 방법으로 측정하였고, 그 결과를 도 7에 나타내었으며, 홀이 거의 형성되지 않는 것을 확인할 수 있었으며, 이는 전압이 낮은 결과, 홀을 형성시키기에 불충분한 전압을 가한 결과로 판단된다.A porous resin needle was prepared in the same manner as in Example 1, but a porous resin needle was prepared by applying a voltage at DC 10V for 30 minutes. And, the SEM measurement thereof was measured in the same manner as in Example 1, the results are shown in Figure 7, it was confirmed that the hole is hardly formed, which results in a low voltage, insufficient to form the hole It is judged by the result of applying the voltage.
비교예 2Comparative Example 2
상기 실시예 1과 동일한 방법으로 다공성 수지침을 제조하되, 전압을 DC 40V로 30분 동안 가하여 다공성 수지침을 제조하였다. 그리고, 이의 SEM 측정을 상기 실시예 1과 동일한 방법으로 측정하였고, 그 결과를 도 8에 나타내었으며, 수지침이 대부분 녹아 내리고 특히 중가에서 침이 끊어지는 문제가 있음을 확인할 수 있었다.A porous resin needle was prepared in the same manner as in Example 1, but a porous resin needle was prepared by applying a voltage at DC 40V for 30 minutes. In addition, the SEM measurement thereof was measured in the same manner as in Example 1, and the results are shown in FIG. 8, and the resin needles were mostly melted, and it was confirmed that there was a problem that the needle was broken in the middle.
실험예 3 : 비표면적 측정 실험Experimental Example 3 Specific Surface Area Measurement Experiment
상기 실시예 1 ~ 실시예 6에서 제조한 다공성 수지침에 대한 비표면적 측정실험을 수행하였으며, 그 결과를 하기 표 2 및 도 9에 나타내었다. 그리고, 비표면적실험은 수지침을 메틸렌 블루 용액에 한침시킨 후, 이를 꺼내서 증류수가 담긴 비이커에 담지 및 흔들어서 수지침 내부에 담지된 메틸렌 블루 용액이 증류수에 모두 용해되도록 하였다. 다음으로, 메틸렌 블루 용액이 용해된 증류수의 흡광도를 측정하여 다공성 수지침에 담지된 메틸렌 블루의 양을 확인하였다. 이를 통해서 수지침의 표면에 묻어난 메틸렌 블루 용액의 양을 측정한 뒤 비표면적을 계산해 내는 방법에 의거하여 측정하였다. 이때, 비표면적을 구하는 방법은 하기 수학식 1에 의거하여, 양극산화 전후의 수지침에 담지된 메틸렌블루 수용액의 흡광도를 측정하여 메틸렌블루의 농도(Concentration)를 구한 후, 이를 이용하여 하기 비례식 1에 대입하여 비표면적을 측정하였다. Specific surface area measurement experiments were performed on the porous resin needles prepared in Examples 1 to 6, and the results are shown in Table 2 and FIG. 9. In the specific surface area experiment, the needle was immersed in a methylene blue solution, and then taken out, soaked in a beaker containing distilled water and shaken so that the methylene blue solution supported in the resin needle was dissolved in distilled water. Next, the absorbance of the distilled water in which the methylene blue solution was dissolved was measured to determine the amount of methylene blue supported on the porous resin needle. Through this, the amount of methylene blue solution buried on the surface of the resin needle was measured and then measured based on the method of calculating the specific surface area. At this time, the method for obtaining the specific surface area is based on Equation 1 below, by measuring the absorbance of the aqueous methylene blue solution supported on the resin needle before and after anodization to determine the concentration of methylene blue (Concentration), using the following proportional formula 1 The specific surface area was measured by substitution.
[수학식 1][Equation 1]
Concentration (M) = 1.667e-5(M/Abs)×Absorption(Abs)Concentration (M) = 1.667e -5 (M / Abs) × Absorption (Abs)
상기 수학식 1에 있어서, 1.667e-5(M/Abs)은 농도를 알고 있는 메틸렌블루 수용액을 흡광도 실험을 통해서 얻어낸 conversion factor이다.In Equation 1, 1.667e -5 (M / Abs) is a conversion factor obtained through an absorbance experiment of methylene blue aqueous solution having a known concentration.
[비례식 1][Proportion 1]
Concentration 1 : 0.0017 (m2/g) = Concentration 2 : 양극산화 후에 수지침의 비표면적Concentration 1: 0.0017 (m 2 / g) = Concentration 2: Specific surface area of resin needle after anodization
상기 비례식 1에서, Concentration 1은 양극산화 전의 수지침에 담지된 메틸렌블루의 농도이고, Concentration 2는 양극산화 후의 수지침에 담지된 메틸렌블루의 농도이다. 그리고, 상기 양극산화 전의 비표면적은 0.0017 (m2/g)로 바늘의 두께와 길이, 무게를 통해 계산한 것이다.In the proportional formula 1, Concentration 1 is the concentration of methylene blue supported on the resin needle before anodization, Concentration 2 is the concentration of methylene blue supported on the resin needle after anodization. The specific surface area before the anodization is 0.0017 (m 2 / g), which is calculated through the thickness, length, and weight of the needle.
표 2
구분 전압세기(V) 비표면적(m2/g) 표면 넓이 100㎛2 당 홀 개수 비고
실시예 1 20 10.89 100 ~ 150 -
실시예 2 15 8.90 15 ~ 20 -
실시예 3 25 6.35 140 ~ 180 -
실시예 4 30 4.98 160 ~ 200 -
비교예 1 10 6.28 1 홀이 거의 없음
비교예 2 40 측정불가 0 수지침 끊어짐
TABLE 2
division Voltage strength (V) Specific surface area (m 2 / g) Surface area 100㎛ 2 holes per 2 Remarks
Example 1 20 10.89 100 to 150 -
Example 2 15 8.90 15 to 20 -
Example 3 25 6.35 140 to 180 -
Example 4 30 4.98 160-200 -
Comparative Example 1 10 6.28 One Almost no holes
Comparative Example 2 40 Not measurable 0 Needle broken
상기 표 2를 살펴보면, 양극산화처리 공정을 전압세기 DC 10 ~ 25V에서 수행한 실시예 1 ~ 실시예 4의 경우, 4.5 m2/g 이상으로 형성된 것을 확인할 수 있으며, 도한, 홀 개수가 15 개 이상, 바람직하게는 100 개 이상으로 형성된 것을 확인할 수 있다.Looking at Table 2, it can be seen that in Examples 1 to 4, in which the anodizing process was performed at a voltage intensity of DC 10 to 25V, it was formed at 4.5 m 2 / g or more. As mentioned above, it can confirm that it formed preferably 100 or more.
그러나, 전압세기가 DC 40V 였던, 비교예 2의 경우, 수지침이 끊어지고 홀이 거의 형성되지 않아서, 비표면적을 측정할 수 없었다.However, in Comparative Example 2, in which the voltage intensity was DC 40V, the resin needle was broken and almost no holes were formed, so the specific surface area could not be measured.
또한, 전압세기가 DC 30V에서 실시하였던 실시예 4의 경우, 홀 개수는 가장 많이 형성되었으나, 실시예 1 ~ 3과 비교할 때, 비표면적이 5.0 m2/g 미만으로 낮은 결과를 보였다.In addition, in Example 4 in which the voltage intensity was performed at DC 30V, the number of holes was formed the most, but the specific surface area was lower than 5.0 m 2 / g when compared to Examples 1 to 3.
도 9를 살펴보면, 20V 전압세기에서 양극산화반응을 수행한 실시예 1이 흡광도가 가장 높았으며, 15V 전압세기에서 양극산화반응을 수행한 실시예 2 의 다공성 수지침 또한, 높은 흡광도를 보였다. 그리고, 30V 전압세기로 실시하였던 실시예4의 경우, 실시예 1, 실시예 2 및 실시예 3 보다는 낮은 흡광도 결과를 보였다.Referring to FIG. 9, the absorbance of Example 1 which performed anodization at 20V voltage intensity was the highest, and the porous resin needle of Example 2 which performed anodization at 15V voltage intensity also showed high absorbance. In the case of Example 4, which was carried out at 30 V voltage intensity, absorbance results were lower than those of Examples 1, 2, and 3.
제조예 1 : 약물이 담지된 다공성 수지침의 제조Preparation Example 1 Preparation of Porous Resin Needles Supported with Drugs
상기 실시예 1에서 제조한 다공성 수지침을 메틸렌블루 용액에 담그는 방법으로 다공성 수지침의 홀에 약물이 담지될 수 있다.The drug may be supported in the hole of the porous resin needle by dipping the porous resin needle prepared in Example 1 in a methylene blue solution.
그리고, 염료가 담지된 다공성 수지침의 무게를 측정한 결과, 수지침의 무게가 염료 담지 전에는 0.1 ㎎ 이었는데, 염료를 담지시킨 후, 무게가 0.1007 ㎎이었고, 0.7% 증가하였으며, 이를 통하여 효과적으로 약물이 홀에 담지되는 것을 확인할 수 있었다.And, as a result of measuring the weight of the dye-supported porous resin needle, the weight of the resin needle was 0.1 mg before the dye was loaded, the weight was 0.1007 mg, 0.7% increased after loading the dye, through which the drug effectively It could be confirmed that it is supported.
상기 실시예 및 실험예를 통하여 본 발명의 다공성 수지침의 표면에 홀이 잘 형성되어, 높은 비표면적을 갖는 것을 확인할 수 있었으며, 또한, 표면에 형성된 홀에 약물이 잘 담지되는 것을 확인할 수 있었다. Through the above examples and experimental examples, the hole was well formed on the surface of the porous resin needle of the present invention, and it was confirmed that it had a high specific surface area, and it was also confirmed that the drug was well supported in the hole formed on the surface.
본 발명의 다공성 수지침을 이용하여 수지침 시술을 통한 획기적인 치료 효과 증대를 꾀할 수 있으며, 이러한 효과가 갖는 의료용 수지침을 제공할 수 있다.By using the porous resin needle of the present invention can be achieved a significant therapeutic effect through the resin needle treatment, it is possible to provide a medical resin needle having this effect.

Claims (10)

  1. 표면 넓이 100㎛2당 15 ~ 200개의 홀(hole)을 표면에 포함하는 것을 특징으로 하는 다공성 수지침.Porous resin needle, characterized in that it comprises 15 to 200 holes (hole) per surface area 100㎛ 2 in the surface.
  2. 제1항에 있어서, 상기 홀은 평균지름이 0.3㎛ ~ 1.5㎛인 것을 특징으로 하는 다공성 수지침.The porous resin needle of claim 1, wherein the holes have an average diameter of 0.3 µm to 1.5 µm.
  3. 제1항에 있어서, 상기 홀은 평균깊이가 0.2㎛ ~ 1㎛인 것을 특징으로 하는 다공성 수지침.The porous resin needle of claim 1, wherein the hole has an average depth of 0.2 µm to 1 µm.
  4. 제1항에 있어서, 상기 홀 내부에 약물이 담지된 것을 특징으로 하는 다공성 수지침.The porous resin needle of claim 1, wherein a drug is supported in the hole.
  5. 제1항 내지 제4항 중에서 선택된 어느 한 항에 있어서,The method according to any one of claims 1 to 4,
    수지침의 표면에 묻어난 메틸렌 블루 용액의 양을 측정한 뒤, 비표면적을 계산해 내는 방법에 의거하여 측정시, 비표면적 4.5 ㎡/g ~ 12.0 ㎡/g 인 것을 특징으로 하는 다공성 수지침.A porous resin needle having a specific surface area of 4.5 m 2 / g to 12.0 m 2 / g when measured according to a method of calculating the specific surface area after measuring the amount of methylene blue solution buried on the surface of the resin needle.
  6. 제5항에 있어서, EDS(Energy Dispersive Spectrometer) 측정 시,The method according to claim 5, wherein when measuring an energy dispersive spectrometer (EDS),
    철(Fe) 25% ~ 27%, 크롬(Cr) 7% ~ 9%, 탄소(C) 62% ~ 64%, 니켈(Ni) 2% ~ 3% 및 실리콘(Si) 0.2% ~ 0.3%를 포함하는 것을 특징으로 하는 다공성 수지침.25% to 27% iron (Fe), 7% to 9% chromium (Cr), 62% to 64% carbon (C), 2% to 3% nickel (Ni), and 0.2% to 0.3% silicon (Si) Porous resin needles comprising a.
  7. 침을 양극산화처리공정을 수행하여 침의 표면에 다공성 구조를 형성시키는 것을 특징으로 하는 다공성 수지침의 제조방법.A method of producing a porous resin needle, characterized in that to form a porous structure on the surface of the needle by performing anodizing process of the needle.
  8. 제7항에 있어서, 상기 양극산화처리공정은The method of claim 7, wherein the anodizing process
    상기 침 및 탄소전극을 포함하는 전해액 내에 수행하고,In the electrolyte containing the needle and the carbon electrode,
    상기 침은 (+)극으로서 사용하고, 상기 탄소전극은 (-)극으로서 사용하며,  The needle is used as a (+) electrode, the carbon electrode is used as a (-) electrode,
    10분 ~ 1시간 동안 12V ~ 30V의 직류를 가하여 수행하는 것을 특징으로 하는 다공성 수지침의 제조방법.Method for producing a porous resin needle, characterized in that performed by applying a direct current of 12V ~ 30V for 10 minutes ~ 1 hour.
  9. 제8항에 있어서, 상기 전해액은 에틸렌 글라이콜 수용액 및 글리세롤 수용액 중에서 선택된 1종 이상을 포함하는 것을 특징으로 하는 다공성 수지침의 제조방법.The method of claim 8, wherein the electrolyte solution comprises at least one selected from ethylene glycol aqueous solution and glycerol aqueous solution.
  10. 제8항에 있어서, 상기 전해액은 플루오린화 암모늄 0.1 ~ 0.5 중량% 및 물 1 ~ 5 중량%를 함유한 에틸렌 글라이콜 수용액인 것을 특징으로 하는 다공성 수지침의 제조방법.9. The method of claim 8, wherein the electrolyte is an aqueous solution of ethylene glycol containing 0.1 to 0.5% by weight of ammonium fluoride and 1 to 5% by weight of water.
PCT/KR2015/002432 2014-10-27 2015-03-13 Porous hand acupuncture needle and manufacturing method therefor WO2016068405A1 (en)

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Citations (4)

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Publication number Priority date Publication date Assignee Title
JP2008079919A (en) * 2006-09-28 2008-04-10 Toppan Printing Co Ltd Needle body and method for producing needle body
KR20080112759A (en) * 2007-06-22 2008-12-26 이승호 Needle with controled surface shape and physical properties
US20110245856A1 (en) * 2010-03-30 2011-10-06 Taiwan Shan Yin International Co., Ltd. Porous acupuncture needle
KR20110113589A (en) * 2010-04-09 2011-10-17 서울대학교산학협력단 A manufacturing method for enhancing biomolecule loading property implant materials by using porous titania layer and implant materials fabricated there by

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR200433930Y1 (en) 2006-09-29 2006-12-13 김세영 The spittle of bee toxin

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008079919A (en) * 2006-09-28 2008-04-10 Toppan Printing Co Ltd Needle body and method for producing needle body
KR20080112759A (en) * 2007-06-22 2008-12-26 이승호 Needle with controled surface shape and physical properties
US20110245856A1 (en) * 2010-03-30 2011-10-06 Taiwan Shan Yin International Co., Ltd. Porous acupuncture needle
KR20110113589A (en) * 2010-04-09 2011-10-17 서울대학교산학협력단 A manufacturing method for enhancing biomolecule loading property implant materials by using porous titania layer and implant materials fabricated there by

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