WO2016043849A3 - Compounds for treating acute respiratory distress syndrome or a negative effect thereof - Google Patents

Compounds for treating acute respiratory distress syndrome or a negative effect thereof Download PDF

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Publication number
WO2016043849A3
WO2016043849A3 PCT/US2015/042139 US2015042139W WO2016043849A3 WO 2016043849 A3 WO2016043849 A3 WO 2016043849A3 US 2015042139 W US2015042139 W US 2015042139W WO 2016043849 A3 WO2016043849 A3 WO 2016043849A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
acute respiratory
treating acute
negative effect
respiratory distress
Prior art date
Application number
PCT/US2015/042139
Other languages
French (fr)
Other versions
WO2016043849A2 (en
Inventor
Kobina N. Dufu
Mira P. Patel
Joshua Eli LEHRER-GRAIWER
Original Assignee
Global Blood Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Global Blood Therapeutics, Inc. filed Critical Global Blood Therapeutics, Inc.
Publication of WO2016043849A2 publication Critical patent/WO2016043849A2/en
Publication of WO2016043849A3 publication Critical patent/WO2016043849A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compounds of formulas I, Ia, Ib, Ic, Id, Ic-1, Id-1, Ie-1, Ie, If, Ig, Ih, Ii, Ij, Ik, IL, Im, In, Io, Ip, Iq, Ir, Is, It, Iu, Iv, Iw, Ix, X-I, II, IIA, IIB, IIC, Iy, X-I-1, III, IIIA, IIIB, IIIC, Iz, IV, V, VI, VII, A, Iz-1, Iaa, I', IA', IB', IC', Ibb, Icc, Idd, Iee, Iff, A25, Igg, IV-5, Ihh, Iii, Ijj, Ikk, ILL, Imm, Inn, IVA, VA, VIA, Ipp, Iqq, Irr, Iss, Iuu, Ivv, Iww, IIIA-1, IIIB-1, or IIICutilized herein are useful for treating acute respiratory disorder syndrome or one or more negative effects thereof, and for increasing oxygen content under hypoxia.
PCT/US2015/042139 2014-07-24 2015-07-24 Compounds for treating acute respiratory distress syndrome or a negative effect thereof WO2016043849A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462028709P 2014-07-24 2014-07-24
US62/028,709 2014-07-24
US201462053671P 2014-09-22 2014-09-22
US62/053,671 2014-09-22

Publications (2)

Publication Number Publication Date
WO2016043849A2 WO2016043849A2 (en) 2016-03-24
WO2016043849A3 true WO2016043849A3 (en) 2016-05-26

Family

ID=55275153

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2015/042139 WO2016043849A2 (en) 2014-07-24 2015-07-24 Compounds for treating acute respiratory distress syndrome or a negative effect thereof

Country Status (1)

Country Link
WO (1) WO2016043849A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201802911RA (en) 2013-03-15 2018-05-30 Global Blood Therapeutics Inc Compounds and uses thereof for the modulation of hemoglobin
EP2970308B1 (en) 2013-03-15 2021-07-14 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
MX2015011769A (en) 2013-03-15 2016-06-02 Global Blood Therapeutics Inc Compounds and uses thereof for the modulation of hemoglobin.
EA201992707A1 (en) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. COMPOUNDS AND THEIR APPLICATIONS FOR HEMOGLOBIN MODULATION
PT3102208T (en) 2014-02-07 2021-04-05 Global Blood Therapeutics Inc Crystalline polymorphs of the free base of 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
MA41841A (en) * 2015-03-30 2018-02-06 Global Blood Therapeutics Inc ALDEHYDE COMPOUNDS FOR THE TREATMENT OF PULMONARY FIBROSIS, HYPOXIA, AND AUTOIMMUNE AND CONNECTIVE TISSUE DISEASES
BR112018011272A2 (en) 2015-12-04 2018-11-21 Global Blood Therapeutics Inc 2-hydroxy-6 - ((2- (1-isopropyl-1h-pyrazol-5-yl) pyridin-3-yl) methoxy) benzaldehyde dosage regimens
EP3860975B1 (en) 2018-10-01 2023-10-18 Global Blood Therapeutics, Inc. Modulators of hemoglobin for the treatment of sickle cell disease
US11014908B2 (en) 2018-11-29 2021-05-25 Pfizer Inc. Chemical compounds
EP4126832A1 (en) * 2020-03-31 2023-02-08 Global Blood Therapeutics, Inc. Modulators of hemoglobin
AU2021251000A1 (en) * 2020-04-10 2022-11-10 Purdue Research Foundation Compounds for the treatment of SARS

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0054924A2 (en) * 1980-12-18 1982-06-30 The Wellcome Foundation Limited Pharmaceutical compounds, their preparation and use
WO2011146471A1 (en) * 2010-05-18 2011-11-24 Aesrx Llc Treatment for altitudinal hypoxia
WO2013102142A1 (en) * 2011-12-28 2013-07-04 Global Blood Therapeutics, Inc. Substituted benzaldehyde compounds and methods for their use in increasing tissue oxygenation
WO2013102145A1 (en) * 2011-12-28 2013-07-04 Global Blood Therapeutics, Inc. Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation
WO2014145040A1 (en) * 2013-03-15 2014-09-18 Global Blood Therapeutics, Inc. Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
WO2014150256A1 (en) * 2013-03-15 2014-09-25 Global Blood Therapeutics, Inc. Compositions and methods for the modulation of hemoglobin (s)
WO2014150268A1 (en) * 2013-03-15 2014-09-25 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2179987E (en) 2002-12-04 2013-03-11 Univ Virginia Commonwealth Use of heterocyclic carbaldehyde derivatives against sickle cell anemia
US7119208B2 (en) 2003-12-03 2006-10-10 Virginia Commonwealth University Anti-sickling agents
EP2731602A1 (en) 2011-07-15 2014-05-21 AesRx, LLC Treatment for hypoxia

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0054924A2 (en) * 1980-12-18 1982-06-30 The Wellcome Foundation Limited Pharmaceutical compounds, their preparation and use
WO2011146471A1 (en) * 2010-05-18 2011-11-24 Aesrx Llc Treatment for altitudinal hypoxia
WO2013102142A1 (en) * 2011-12-28 2013-07-04 Global Blood Therapeutics, Inc. Substituted benzaldehyde compounds and methods for their use in increasing tissue oxygenation
WO2013102145A1 (en) * 2011-12-28 2013-07-04 Global Blood Therapeutics, Inc. Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation
WO2014145040A1 (en) * 2013-03-15 2014-09-18 Global Blood Therapeutics, Inc. Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
WO2014150256A1 (en) * 2013-03-15 2014-09-25 Global Blood Therapeutics, Inc. Compositions and methods for the modulation of hemoglobin (s)
WO2014150268A1 (en) * 2013-03-15 2014-09-25 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
MIRA ET AL.: "GTx011, a Novel Agent That Improves Rheological Properties Of Sickle Cell Blood By Increasing Oxygen Affinity For Hemoglobin", BLOOD, vol. 122, no. 21, November 2013 (2013-11-01), 55TH ANNUAL MEETING OF THE AMERICAN-SOCIETY-OF-HEMATOLOGY; NEW ORLEANS, LA, USA; DECEMBER 07 -10, 2013, pages 2207, XP009189207 *
OSHEIZA ABDULMALIK ET AL: "Crystallographic analysis of human hemoglobin elucidates the structural basis of the potent and dual antisickling activity of pyridyl derivatives of vanillin", ACTA CRYSTALLOGRAPHICA SECTION D BIOLOGICAL CRYSTALLOGRAPHY, vol. 125, no. 11, 1 November 2011 (2011-11-01), pages 788 - 928, XP055203573, ISSN: 0907-4449, DOI: 10.1107/S0907444911036353 *
ROLAN P E ET AL: "The pharmacokinetics, tolerability and pharmacodynamics of tucaresol (589C80); 4[2-formyl-3-hydroxyphenoxymethyl] benzoic acid), a potential anti-sickling agent, following oral administration to healthy subjects", BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, BLACKWELL SCIENTIFIC PUBL, GB, vol. 35, no. 4, 1 April 1993 (1993-04-01), pages 419 - 425, XP002000120, ISSN: 0306-5251 *

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