WO2016018860A1 - Stabilisateur colloïdal amélioré - Google Patents

Stabilisateur colloïdal amélioré Download PDF

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Publication number
WO2016018860A1
WO2016018860A1 PCT/US2015/042373 US2015042373W WO2016018860A1 WO 2016018860 A1 WO2016018860 A1 WO 2016018860A1 US 2015042373 W US2015042373 W US 2015042373W WO 2016018860 A1 WO2016018860 A1 WO 2016018860A1
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composition
carboxymethylcellulose
stabilizer composition
microcrystalline cellulose
component
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PCT/US2015/042373
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English (en)
Inventor
Zheng Tan
Fernanda De Oliveira ONOFRE
Parminder Agarwal
Holly BERTRAND
Brian Carlin
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Fmc Corporation
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
    • C08L1/08—Cellulose derivatives
    • C08L1/26—Cellulose ethers
    • C08L1/28—Alkyl ethers
    • C08L1/286—Alkyl ethers substituted with acid radicals, e.g. carboxymethyl cellulose [CMC]

Definitions

  • the present invention is directed to a stabilizer composition
  • a stabilizer composition comprising a mixture of (a) co-attrited microcrystalline cellulose and low or medium viscosity carboxymethylcellulose; and (b) high viscosity carboxymethylcellulose; produced by the dry blending of components (a) and (b).
  • the present invention is directed to an aqueous dispersion comprising such stabilizer composition; a method of making such a stabilizer composition; as well as to a food, pharmaceutical, nutraceutical or industrial product comprising such a stabilizer composition.
  • Microcrystalline cellulose also known as MCC or cellulose gel
  • MCC microcrystalline cellulose
  • MCC microcrystalline cellulose
  • it has been used as a binder and stabilizer in food applications, including beverages. It has also been used as a suspending agent in liquid pharmaceutical formulations, a binder and disintegrant in pharmaceutical tablets, and as a pharmaceutical pellet former in extrusion- spheronization. It has also been used as a binder, disintegrant, and processing aid in industrial applications, in household products such as detergent and/or bleach tablets, in agricultural formulations, and in personal care products such as dentifrices and cosmetics.
  • Microcrystalline cellulose and/or hydrolyzed cellulose wet cake has been modified for a variety of uses. In food products it is used as a gelling agent, a thickener, a fat substitute and/or non-caloric filler, and as a suspension stabilizer and/or texturizer. It has also been used as an emulsion stabilizer and suspending agent in pharmaceutical and cosmetic lotions and creams. Modification for such uses is carried out by subjecting microcrystalline cellulose or wet cake to intense attrition (high shear), as a result of which the particles are substantially subdivided to give colloidal microcrystalline cellulose. However, as particle size is diminished, the individual particles tend to hornify upon drying, and may not be redispersible in water.
  • intense attrition high shear
  • a protective colloid such as carboxymethylcellulose (CMC)
  • CMC carboxymethylcellulose
  • the protective colloid wholly or partially neutralizes the hydrogen or other bonding forces between the smaller sized particles.
  • Colloidal microcrystalline cellulose including
  • colloidal microcrystalline cellulose forms white, opaque, thixotropic gels with most of the microcrystalline cellulose particles being less than 1 micron in size.
  • FMC Corporation Philadelphia, PA, USA manufactures and sells various grades of this product which comprise co-processed
  • microcrystalline cellulose and sodium carboxymethylcellulose under the designations of, among others, AVICEL ® and GELSTAR ® .
  • United States Patent Application 2013/0150462 discloses a stabilizer composition produced by co-attriting microcrystalline cellulose with carboxymethylcellulose having or comprising a low viscosity (less than 100 cps) and a higher degree of substitution (0.95-1.5).
  • WO 2013/052114 discloses stabilizer compositions produced by wet blending (a) a co-extruded (co-attrited) microcrystalline cellulose and low substituted (DS of 0.45-0.85) carboxymethylcellulose; with (b) a second
  • Comparative Example IB of WO 2013/052114 indicates that when (a) a dry powder of co-attrited microcrystalline cellulose and low substituted/low viscosity carboxymethylcellulose is dry blended with (b) a dry powder of high substituted/medium viscosity carboxymethylcellulose, the resultant colloid produced upon resuspension exhibits a very low set-up gel strength G' of only 8 Pa.
  • stabilizer compositions produced by dry blending (a) co-attrited microcrystalline cellulose and low or medium viscosity carboxymethylcellulose; and (b) high viscosity
  • carboxymethylcellulose will exhibit desirable set up strengths, particularly as it is not commercially and economically practical to dry such components if they are wet blended. Further, it has been unexpectedly found that such stabilizer compositions exhibit desirable stability and particle suspending power under acidic conditions.
  • the present invention is directed to a stabilizer composition
  • a stabilizer composition comprising a mixture of (a) co-attrited microcrystalline cellulose and low or medium viscosity carboxymethylcellulose; and (b) high viscosity carboxymethylcellulose; produced by the dry blending of components (a) and (b).
  • the present invention is directed to an aqueous suspension comprising: (A) a stabilizer composition comprising a mixture of (a) co-attrited microcrystalline cellulose and low or medium viscosity carboxymethylcellulose; and (b) high viscosity carboxymethylcellulose; produced by the dry blending of components (a) and (b); and (B) water.
  • the present invention is directed to a method of making a stabilizer composition comprising dry blending (a) co-attrited microcrystalline cellulose and low or medium viscosity carboxymethylcellulose; and (b) high viscosity carboxymethylcellulose.
  • the present invention is directed to a food, pharmaceutical, nutraceutical or industrial product comprising such a stabilizer composition.
  • the present invention is directed to a stabilizer composition
  • a stabilizer composition comprising a mixture of (a) co-attrited microcrystalline cellulose and low or medium viscosity carboxymethylcellulose; and (b) high viscosity carboxymethylcellulose.
  • colloidal particles are used interchangeably in the specification to define particles that may be suspended in a mixture.
  • colloidal particles are of a certain average particle size, for example, on the order of about 0.1 to 10 microns.
  • the colloidal particles described herein may be of any suitable particle size, provided that they are able to form colloidal suspensions.
  • gel refers to a soft, solid, or solid-like material which consists of at least two components, one of which is a liquid present in abundance (Almdal, K., Dyre, J., Hvidt, S., Kramer, O.; Towards a
  • the co-attrited component of the stabilizer of this invention comprises microcrystalline cellulose ("MCC”) and a low or medium viscosity
  • CMC carboxymethylcellulose
  • MCC from any source may be employed in such component.
  • Suitable feedstocks from which MCC may be obtained include, for example, wood pulp (such as bleached sulfite and sulfate pulps), corn husks, bagasse, straw, cotton, cotton linters, flax, hemp, ramie, seaweed, cellulose, and fermented cellulose.
  • Additional feedstocks include bleached softwood Kraft pulps, bleached hardwood Kraft pulps, bleached Eucalyptus Kraft pulps, paper pulps, fluff pulps, dissolving pulps, and bleached non-wood cellulosic pulps.
  • the MCC used is one approved for human consumption by the United States Food and Drug Administration.
  • the MCC may be made from a low cost pulp or mixtures of low cost pulp and specialty pulp. If a mixture is desired, then, for example, 30-80% of the total MCC can be from made from low cost pulp, and the colloidal content of the resulting MCC product can be at least 60%.
  • low cost pulp include any paper grade pulp and fluff pulp, such as Southern Bleached Softwood Kraft Pulp, Northern Bleached Softwood Pulp, Bleached Eucalyptus Kraft Pulp, Bleached Hardwood Kraft Pulp, Bleached Sulfite Pulps, Bleached Soda Pulps, and bleached non-wood pulps. Specific low cost pulps include CPH pulp from Weyerhaeuser and Viscose grade dissolving pulps.
  • MCC more amenable to extrusion/attrition intensity.
  • the MCC slurry can be treated with peroxide, peracetic acid, performic acid, persulfate, peroxymonosulfate (Oxone), or ozone at acidic pH.
  • the acid hydrolysis process to make MCC may also be enhanced with other additives (such as iron salts, i.e., ferric chloride, ferrous sulfate).
  • Another approach is to extend the cooking time of MCC acid hydrolysis as shown in Example 5 of US 2013/0090391. The effect of extended cooking time may also be achieved by varying other conditions of the acid hydrolysis, including a higher acid
  • the carboxymethylcellulose employed in the co-attrited component of the present stabilizer composition comprises an alkali metal carboxymethylcellulose, for instance, sodium, potassium, or ammonium CMC. Most preferably, the alkali metal carboxymethylcellulose, for instance, sodium, potassium, or ammonium CMC. Most preferably, the alkali metal carboxymethylcellulose, for instance, sodium, potassium, or ammonium CMC.
  • carboxymethylcellulose is sodium CMC.
  • the CMC is characterized by its viscosity, as measured in a 2% aqueous solution, at 25 °C (Brookfield). Such viscosity may be determined by devices and settings well known to one of ordinary skill in the art, such as those described in the brochure AQUALON ® CMC, An Anionic Water-Soluble Polymer, Hercules Incorporated, 1999, the disclosure of which is hereby incorporated by reference.
  • "low viscosity" CMC has a range of 10 to 200 cps (measured at 60 rpm using a Spindle Number 1 or 2).
  • medium viscosity CMC has a range of 200 to 4000 cps (measured at 30 rpm using a Spindle Number 2).
  • a “high viscosity” CMC has a viscosity which has a viscosity higher than medium viscosity CMC as defined and measured above.
  • High viscosity CMC has a viscosity higher than 4,000 cps when tested at 2% solids.
  • high viscosity CMC is tested at 1% solids (measured at 30 rpm using a Spindle Number 3 or 4).
  • the degree of substitution (DS) of the CMC employed is not critical for many applications.
  • the degree of substitution represents the average number of hydroxyl groups substituted per anhydroglucose unit.
  • each anhydroglucose unit contains three hydroxyl groups, which gives CMC a maximum theoretical DS of 3.0.
  • the MCC and low and/or medium viscosity CMC can be co-attrited by means well known to one of ordinary skill in the art, such as those described in US Patent Application 2013/0090391 which is hereby incorporated by reference.
  • the methods include mixing a water-soluble carboxymethylcellulose with
  • microcrystalline cellulose wet cake of at least 42% solids wherein the weight ratio of the microcrystalline cellulose to the carboxymethylcellulose is about 95:5 to about 70:30.
  • a particular weight ratio of the microcrystalline cellulose to the carboxymethylcellulose is about 90: 10 to about 70:30; a more particular weight ratio of the microcrystalline cellulose to the carboxymethylcellulose is about 90:10 to about 80:20.
  • the moist mixture is extruded with sufficient intensity to achieve co-attrition and interaction among the components.
  • attrited and “attrition” are used interchangeably to mean a process that effectively reduces the size of at least some if not all of the particles to a colloidal size.
  • the processing is a mechanical processing that introduces shearing force either to an MCC wet cake before blending with CMC or to an admixture of MCC wet cake and CMC.
  • “Co-attrition” refers to application of high shear forces to an admixture of the MCC and CMC component. Suitable attrition conditions may be obtained, for example, by co-extruding, milling, or kneading.
  • the extrudate can be dried or be dispersed in water to form a slurry.
  • the slurry can be homogenized and dried, preferably spray dried. Drying processes other than spray drying include, for example, fluidized bed drying, drum drying, bulk drying, and flash drying. Dry particles formed from the spray drying can be reconstituted in a desired aqueous medium or solution to form the compositions, edible food products, pharmaceutical applications, and industrial applications described herein.
  • shear force refers to an action resulting from applied force that causes or tends to causes two contiguous parts of a mixture to slide relative to each other in a direction generally parallel to their plane of contact.
  • the amount of force applied must be sufficient to create associations between the microcrystalline cellulose particles and the carboxymethylcellulose. If the force applied is insufficient, the components remain too “slippery” to transfer the shear force applied to the material or admixture to accomplish intimate associations. In that case, the shear force is primarily dissipated as mechanical energy by sliding action.
  • any means to increase the extrusion intensity may be used, including, but not limited to, extruder designs, duration/passes of extrusions, extrusion with attriting aids including all mentioned by FMC patent US Pat. 6,037,380 (Venables et al.), high shear/high solids levels, and anti-slip agents.
  • a preferred way of effecting high extrusion intensity is to control the solids level of the microcrystalline cellulose wet cake to be extruded.
  • a wet cake solids level below about 41% yields a colloidal MCC with a given gel strength G'.
  • the final colloidal MCC product shows a significant increase in gel strength G'.
  • the comprehensive range of the effective wet cake solids level is between about 42% to 60%, preferably 42.5% to 60%, more preferably 42.5% to 55%, and most preferably 43% to 50%.
  • MCC dry (or higher solids) MCC (or colloidal MCC such as Avicel RC591 or Avicel CL611 powders) into the wet cake, thereby increasing the total MCC solids content of the composition.
  • Improved extrusion/attrition intensity may be done with extended extrusion residence time (or more passes), and may also be achieved by cooling the extrusion temperature.
  • the use of any common coolants is included in the invention' s embodiments, and includes, but is not limited to, water cooling, and ammonia cooling.
  • sufficient extrusion/attrition may be achieved in two or more separate steps.
  • the MCC wet cake may be extruded/attrited first and then followed by CMC addition and extrusion/attrition.
  • equipment for attriting MCC wet cake or MCC:CMC include compression rolls/belts, calendaring rolls, mechanical refiner discs, ultrasonic refiners, high pressure homogenizers (including Micro-fluidic devices), high compression planetary mixers, and shockwave/cavitation devices.
  • the high viscosity carboxymethylcellulose which is to be blended or combined with the above co-attrited MCC/CMC, can be of any degree of substitution, usually from 0.45% to 1.5%.
  • Such carboxymethylcellulose can be an alkali metal carboxymethylcellulose, more particularly sodium, potassium, or ammonium carboxymethylcellulose, and most preferably sodium
  • the high viscosity CMC can be products made by any company.
  • CMC products made by Ashland Inc. which may be employed include 7H, 7HOF, 7H3S, 7H4, 9H, 9H4 high viscosity grades.
  • Other high viscosity CMCs such as Drispac (Ashland) may also be used.
  • the co-attrited microcrystalline cellulose and low or medium viscosity carboxymethylcellulose (component a) and high viscosity carboxymethylcellulose (component b) may be dry blended by means well known to one of ordinary skill in the art such as various ribbon mixers, paddle blenders or plow mixers, vertical blenders, and various tumble blenders including V blenders.
  • various high shear mixers with single or multiple shafts, single or multiple axis, are also included.
  • Some liquid o may be present or may be added during the dry blending process so long as no drying step is required to produce a free flowing powder once the blending is complete.
  • the weight ratio of component (a):component (b) is typically between 99:1 and 40:60; and is preferably between 97:3 and 50:50. For acidic pH applications, ratios of 90:10 to 50:50 are typically employed.
  • the present invention is directed to an aqueous suspension comprising: (A) a stabilizer composition comprising a mixture of (a) co-attrited microcrystalline cellulose and low or medium viscosity carboxymethylcellulose; and (b) high viscosity carboxymethylcellulose; produced by the dry blending of components (a) and (b); and (B) water.
  • aqueous suspension The amount of stabilizer composition contained in such aqueous suspension will vary upon the particular application involved, but will typically range between 0.1 and 10 percent by weight, based upon the weight of stabilizer composition and water present.
  • aqueous composition may optionally comprise additional components, for example, organic liquids such as ethanol, methanol, isopropanol, glycols, and the like, depending upon the use of the product comprising such aqueous suspension.
  • the stabilizer compositions of this invention when dispersed in water, exhibit unexpectedly desirable rheological properties, gel strength and acid stability.
  • Rheological properties including elastic modulus G' and thixotropy, are tested by rheometers as specified in the Examples.
  • the Brookfield viscosity test is used in the Examples to obtain an initial viscosity on the activated compositions at 60 seconds (usually 2.6% solids dispersion of the material in deionized water), and repeated to obtain the set-up viscosity after 24 hours.
  • a RVT viscometer, with an appropriate spindle, is used at 20 rpm, at 20° C to 23 °C.
  • compositions typically exhibit a gel elastic modulus (G') of at least 30 Pa, when dispersed in water at 2.6% by weight solids.
  • G' gel elastic modulus
  • such compositions exhibit a G' of at least 40 Pa, more preferably of at least 50 Pa.
  • compositions typically exhibit an improved thixotropy (relative to the particular co-attrited MCC/CMC component employed alone) by at least 50 Pa/s. In one embodiment, the improvement by 300 Pa/s or more; preferably by 450 Pa/s or more; and more preferably by 600 Pa/s or more.
  • compositions are suitable for a wide variety of food, pharmaceutical, nutraceutical and industrial applications including in cosmetic products, personal care products, consumer products, agricultural products, or in chemical formulations and in paint, polymer formulations.
  • Some examples in pharmaceutical applications include liquid suspending agents and/or emulsions for drugs; nasal sprays for drug delivery where the MCC/CMC gives increased residence and bioavailability; controlled release agents in pharmaceutical applications; and reconstitutable powders which are dry powders mixtures containing drugs which can be made into suspension by adding water and shaking by hand; topical drug applications, and various foams, creams, lotions for medical uses, including compositions for oral care such as toothpaste, mouthwash and the like.
  • One particular example is a suspension of benzoyl peroxide or similar agents which requires the stability of the MCC/CMC against oxidizing agent over time.
  • Other examples include pharmaceutical suspensions (or reconstitutable powders) which are acidic or with high ionic strength.
  • Examples in nutraceutical applications include delivery systems for various nutraceutical ingredients and dietary supplements.
  • Examples in industrial applications include various suspensions, thickeners, which can be used in foams, creams, lotions and sun-screens for personal care applications; suspending agents, which can be used with pigments and fillers in ceramics, or used in colorants, optical brighteners, cosmetics, and oral care in products such as toothpaste, mouthwash and the like; materials such as ceramics; delivery systems for pesticides including insecticides; delivery of herbicides, fungicides, and other agricultural products, and paints, and various chemical or polymer suspensions.
  • One particular example is an industrial wash fluid, containing oxidizing or bleach agents, which demand strong and stable suspension systems.
  • compositions may be used in a variety of food products including emulsions, beverages, sauces, soups, syrups, dressings, films, dairy and non-dairy milks and products, frozen desserts, cultured foods, bakery fillings, and bakery cream. It may also be used for the delivery of flavoring agents and coloring agents.
  • the edible food products can additionally comprise diverse edible material and additives, including proteins, fruit or vegetable juices, fruit or vegetable pulps, fruit- flavored substances, or any combination thereof.
  • These food products can also include other edible ingredients such as, for example, mineral salts, protein sources, acidulants, sweeteners, buffering agents, pH modifiers, stabilizing salts, or a combination thereof.
  • other edible components such as, for example, mineral salts, protein sources, acidulants, sweeteners, buffering agents, pH modifiers, stabilizing salts, or a combination thereof.
  • additional edible ingredients can be soluble or insoluble, and, if insoluble, can be suspended in the food product. Routine adjustment of the composition is fully within the capabilities of one having skill in the art and is within the scope and intent of the present invention.
  • These edible food products can be dry mix products (instant sauces, gravies, soups, instant cocoa drinks, etc.), low pH dairy systems (sour cream/yogurt, yogurt drinks, stabilized frozen yogurt, etc.), baked goods, and as a bulking agent in non- aqueous food systems and in low moisture food systems.
  • Suitable juices incorporating the stabilizer composition include fruit juices (including but not limited to lemon juice, lime juice, and orange juice, including variations such as lemonade, limeade, or orangeade, white and red grape juices, grapefruit juice, apple juice, pear juice, cranberry juice, blueberry juice, raspberry juice, cherry juice, pineapple juice, pomegranate juice, mango juice, apricot juice or nectar, strawberry juice, and kiwi juice) and vegetable juices (including but not limited to tomato juice, carrot juice, celery juice, beet juice, parsley juice, spinach juice, and lettuce juice).
  • fruit juices including but not limited to lemon juice, lime juice, and orange juice, including variations such as lemonade, limeade, or orangeade, white and red grape juices, grapefruit juice, apple juice, pear juice, cranberry juice, blueberry juice, raspberry juice, cherry juice, pineapple juice, pomegranate juice, mango juice, apricot juice or nectar, strawberry juice, and kiwi juice
  • the juices may be in any form, including liquid, solid, or semi- solid forms such as gels or other concentrates, ices or sorbets, or powders, and may also contain suspended solids.
  • fruit-flavored or other sweetened substances including naturally flavored, artificially flavored, or those with other natural flavors ("WONF"), may be used instead of fruit juice.
  • Such fruit flavored substances may also be in the form of liquids, solids, or semi-solids, such as powders, gels or other concentrates, ices, or sorbets, and may also contain suspended solids.
  • Proteins suitable for the edible food products incorporating the stabilizer compositions include food proteins and amino acids, which can be beneficial to mammals, birds, reptiles, and fish.
  • Food proteins include animal or plant proteins and fractions or derivatives thereof.
  • Animal derived proteins include milk and milk derived products, such as heavy cream, light cream, whole milk, low fat milk, skim milk, fortified milk including protein fortified milk, processed milk and milk products including superheated and/or condensed, sweetened or unsweetened skin milk or whole milk, dried milk powders including whole milk powder and nonfat dry milk (NFDM), casein and caseinates, whey and whey derived products such as whey concentrate, delactosed whey, demineralized whey, whey protein isolate.
  • NFDM nonfat dry milk
  • Plant derived proteins include nut and nut derived proteins, sorghum, legume and legume derived proteins such as soy and soy derived products such as untreated fresh soy, fluid soy, soy concentrate, soy isolate, soy flour, and rice proteins, and all forms and fractions thereof.
  • Food proteins may be used in any available form, including liquid, condensed, or powdered. When using a powdered protein source, however, it may be desirable to prehydrate the protein source prior to blending with stabilizer compositions and juice for added stability of the resulting beverage. When protein is added in conjunction with a fruit or vegetable juice, the amount used will depend upon the desired end result. Typical amounts of protein range from about 1 to about 20 grams per 8 oz.
  • the high viscosity CMC (component b) would have also a high degree of substitution, from 0.85%-1.5%.
  • the compositions are formulated as dry blends.
  • the dry blends are suitable intermediates that can be dosed and dispersed with other ingredients including surfactants, fillers, or active substances. Sufficient water and agitation with heat are added as appropriate to activate the stabilizer in a desired food product, pharmaceutical product, nutraceutical product, personal care product, cosmetic product, consumer product, agricultural product, or chemical formulation.
  • Suitable surfactants include, but are not limited to, ionic or nonionic with an HLB of 1 to 40.
  • Active substances may be added to the compositions and include, but are not limited to, at least one of a nutraceutical agent, a vitamin, a mineral, a coloring agent, a sweetener, a flavorant, a fragrance, a salivary stimulant agent, a food, an oral care agent, a breath freshening agent, a pharmaceutical active, agricultural active, therapeutic agent, cosmetic agent, chemical, buffer, or pH modifier. Active substances can be encapsulated or otherwise processed or treated to modify their release properties.
  • the food/beverage compositions may be processed by heat treatment in any number of ways. These methods may include, but are not limited to, pasteurization, ultra pasteurization, high temperature short time pasteurization (“HTST”), and ultra high temperature pasteurization ("UHT”). These beverage compositions may also be retort processed, either by rotary retort or static retort processing. Some compositions, such as juice-added or natural or artificially flavored soft drinks may also be cold processed. Many of these processes may also incorporate homogenization or other high shear/high compression methods. There may also be co-dried compositions, which can be prepared in dry- mix form, and then conveniently reconstituted for consumption as needed. The resulting beverage compositions may be refrigerated and stored for a commercially acceptable period of time. In the alternative, the resulting beverages may be stored at room temperature, provided they are filled under aseptic conditions.
  • each amount/value or range of amounts/values for each component, compound, substituent, or parameter disclosed herein is to be interpreted as also being disclosed in combination with each amount/value or range of amounts/values disclosed for any other component(s), compounds(s), substituent(s), or parameter(s) disclosed herein and that any combination of amounts/values or ranges of amounts/values for two or more component(s), compounds(s), substituent(s), or parameters disclosed herein are thus also disclosed in combination with each other for the purposes of this description.
  • each lower limit of each range disclosed herein is to be interpreted as disclosed in combination with each upper limit of each range disclosed herein for the same component, compounds, substituent, or parameter.
  • a disclosure of two ranges is to be interpreted as a disclosure of four ranges derived by combining each lower limit of each range with each upper limit of each range.
  • a disclosure of three ranges is to be interpreted as a disclosure of nine ranges derived by combining each lower limit of each range with each upper limit of each range, etc.
  • a colloidal microcrystalline cellulose product comprising co-attrited MCC and low DS medium viscosity CMC (Avicel RC591; FMC Corporation) was dry blended with a low degree of substitution, high viscosity (high molecular weight) carboxymethylcellulose product (Aqualon 7HF CMC; Ashland Inc,) at the weight ratios listed in Table 1 below.
  • the mixtures were then dispersed in de-ionized water at 2.6% solids and their rheological properties tested with a TA-Instruments ARES- RFS3 Rheometer with the following conditions:
  • compositions of this invention exhibit unexpectedly desirable properties relative to their components alone.
  • a colloidal microcrystalline cellulose product comprising co-attrited MCC and low DS low viscosity CMC (Avicel CL611; FMC Corporation) was dry blended with a low degree of substitution, high viscosity (high molecular weight) carboxymethylcellulose product (Aqualon 7HF CMC; Ashland Inc,) at the weight ratios listed in Table 2 below.
  • the mixtures were then dispersed in de-ionized water at 2.6% solids and their rheological properties evaluated as described in Example 1.
  • (2-CE) Avicel CL611 alone was tested as well. The results of such testing (at the ratios indicated) are presented in Table 2 below:
  • a colloidal microcrystalline cellulose product comprising co-attrited MCC and low DS medium viscosity CMC (Avicel RC591; FMC Corporation) was dry blended with moderately high degree of substitution, high viscosity
  • carboxymethylcellulose (Aqualon 9 HF CMC; Ashland Inc.) in a 90:10 weight ratio.
  • the mixture were dispersed in de-ionized water at 2.6% solids and its rheological properties evaluated as described in Example 1.
  • the initial viscosity was 17,000 cps, and gel elastic modulus G ' was 60 Pa.
  • a colloidal microcrystalline cellulose product comprising co-attrited MCC and low DS low viscosity CMC was dry blended with a low degree of substitution, high viscosity (high molecular weight) carboxymethylcellulose product (Aqualon 7HF CMC; Ashland Inc,) in the amounts listed in Table 3.
  • the samples so prepared were dispersed in de-ionized water with a propeller mixer for 30 minutes at 800 rpm; and their rheological properties measured at a 2.6% solids level. (2.6% in this example).
  • the dispersed samples were then tested with a TA Instrument AR2000ex Rheometer (TA Instruments) under the following conditions:
  • a colloidal microcrystalline cellulose product comprising co-attrited MCC and low DS low viscosity CMC was dry blended with a low degree of substitution, high viscosity (high molecular weight) carboxymethylcellulose product (Aqualon 7HF CMC; Ashland Inc,) in the weight percentages listed in Table 3. (Examples 5A, 5B and 5C)
  • a colloidal microcrystalline cellulose product comprising co- attrited MCC and high DS low viscosity CMC was dry blended with a low degree of substitution, high viscosity (high molecular weight) carboxymethylcellulose product (Aqualon 7HF CMC; Ashland Inc,) in a 80:20 weight ratio (Example 5D).
  • a thixotropic fluid will form a hysteresis loop when shear stress is plotted against shear rate, which is captured by the rheograms of this experiment.
  • Table 4 shows the magnitude of the hysteresis loop area which is traditionally considered as a measure of thixotropy effect.

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Abstract

Selon un aspect, la présente invention concerne une composition stabilisatrice comprenant un mélange de (a) cellulose microcristalline ayant subi une co-attrition et de carboxyméthylcellulose de viscosité moyenne ou faible; et (b) la carboxyméthylcellulose de viscosité élevée; produite par le mélange à sec de constituants (a) et (b). Selon d'autres aspects, la présente invention concerne une dispersion aqueuse comprenant une telle composition stabilisatrice; un procédé de fabrication d'une telle composition stabilisatrice; ainsi qu'à un aliment, un produit pharmaceutique, un produit nutraceutique ou un produit industriel comprenant une telle composition stabilisatrice.
PCT/US2015/042373 2014-07-29 2015-07-28 Stabilisateur colloïdal amélioré WO2016018860A1 (fr)

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CN111138720A (zh) * 2019-12-24 2020-05-12 牡丹江霖润药用辅料有限责任公司 一种高效的纤维素胶体稳定剂

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US20070128333A1 (en) * 2005-09-30 2007-06-07 Tuason Domingo C Stabilizers and Compositions and Products Comprising Same
US20130064953A1 (en) * 2009-05-26 2013-03-14 Georg Bache Stabilizer for Food Applications
WO2013052114A1 (fr) * 2011-10-05 2013-04-11 Fmc Corporation Composition stabilisante de cellulose et carboxyméthylcellulose microcristallines, procédé de fabrication et utilisations
US20130150462A1 (en) * 2011-12-09 2013-06-13 Fmc Corporation Co-Attrited Stabilizer Composition

Patent Citations (5)

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US5789004A (en) * 1995-12-15 1998-08-04 Fmc Corporation Coprocessed microcrystalline cellulose stabilizer compositions, foods containing the same and stabilization method
US20070128333A1 (en) * 2005-09-30 2007-06-07 Tuason Domingo C Stabilizers and Compositions and Products Comprising Same
US20130064953A1 (en) * 2009-05-26 2013-03-14 Georg Bache Stabilizer for Food Applications
WO2013052114A1 (fr) * 2011-10-05 2013-04-11 Fmc Corporation Composition stabilisante de cellulose et carboxyméthylcellulose microcristallines, procédé de fabrication et utilisations
US20130150462A1 (en) * 2011-12-09 2013-06-13 Fmc Corporation Co-Attrited Stabilizer Composition

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111138720A (zh) * 2019-12-24 2020-05-12 牡丹江霖润药用辅料有限责任公司 一种高效的纤维素胶体稳定剂
CN111138720B (zh) * 2019-12-24 2022-03-04 牡丹江霖润药用辅料有限责任公司 一种高效的纤维素胶体稳定剂

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