WO2016014992A3 - Compositions for treatment, diagnosis and prognosis of diseases - Google Patents

Compositions for treatment, diagnosis and prognosis of diseases Download PDF

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Publication number
WO2016014992A3
WO2016014992A3 PCT/US2015/042084 US2015042084W WO2016014992A3 WO 2016014992 A3 WO2016014992 A3 WO 2016014992A3 US 2015042084 W US2015042084 W US 2015042084W WO 2016014992 A3 WO2016014992 A3 WO 2016014992A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
treatment
prognosis
diseases
diagnosis
Prior art date
Application number
PCT/US2015/042084
Other languages
French (fr)
Other versions
WO2016014992A2 (en
Inventor
Jenny L. PERSSON
Heather H. JOHNSON
Original Assignee
Everest Biosciences, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Everest Biosciences, Inc. filed Critical Everest Biosciences, Inc.
Publication of WO2016014992A2 publication Critical patent/WO2016014992A2/en
Publication of WO2016014992A3 publication Critical patent/WO2016014992A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/01068—1-Phosphatidylinositol-4-phosphate 5-kinase (2.7.1.68)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Abstract

Disclosed herein are novel pharmaceutically-useful compositions comprising an inhibitor of PIP5KIA, which compositions may be useful in the treatment of diseases such as cancer. Also disclosed is the use of the compositions for disease diagnosis and prognosis, treatment selection and disease progression monitoring.
PCT/US2015/042084 2014-07-24 2015-07-24 Compositions for treatment, diagnosis and prognosis of diseases WO2016014992A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462028783P 2014-07-24 2014-07-24
US62/028,783 2014-07-24

Publications (2)

Publication Number Publication Date
WO2016014992A2 WO2016014992A2 (en) 2016-01-28
WO2016014992A3 true WO2016014992A3 (en) 2016-03-17

Family

ID=55163985

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2015/042084 WO2016014992A2 (en) 2014-07-24 2015-07-24 Compositions for treatment, diagnosis and prognosis of diseases

Country Status (1)

Country Link
WO (1) WO2016014992A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106544361A (en) * 2016-12-02 2017-03-29 新乡医学院 Mammalian cell expression vector, expression system, preparation method and application

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030114400A1 (en) * 2001-12-06 2003-06-19 Isis Pharmaceuticals Inc. Antisense modulation of phosphatidylinositol-4-phosphate 5-kinase, Ialpha expression

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030114400A1 (en) * 2001-12-06 2003-06-19 Isis Pharmaceuticals Inc. Antisense modulation of phosphatidylinositol-4-phosphate 5-kinase, Ialpha expression

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
LI ET AL.: "The ATM Inhibitor KU-55933 Suppresses Cell Proliferation and Induces Apoptosis by Blocking Akt In Cancer Cells with Overactivated Akt.", MOL CANCER THER, vol. 9, no. 1, January 2010 (2010-01-01), pages 113 - 125 *
MUSCOLINI ET AL.: "Phosphatidylinositol 4-Phosphate 5-Kinase alpha Activation Critically Contributes to CD 28-Dependent Signaling Responses.", THE JOURNAL OF IMMUNOLOGY, vol. 190, no. 10, 15 May 2013 (2013-05-15), pages 5279 - 5286 *
VAN DEN BOUT ET AL.: "PIP5K-driven Ptdlns(4,5)P2 synthesis: regulation and cellular function.", J CELL SCI, vol. 122, no. 21, 1 November 2009 (2009-11-01), pages 3837 - 3850 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106544361A (en) * 2016-12-02 2017-03-29 新乡医学院 Mammalian cell expression vector, expression system, preparation method and application

Also Published As

Publication number Publication date
WO2016014992A2 (en) 2016-01-28

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