WO2015162552A3 - Composition for topic use - Google Patents

Composition for topic use Download PDF

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Publication number
WO2015162552A3
WO2015162552A3 PCT/IB2015/052895 IB2015052895W WO2015162552A3 WO 2015162552 A3 WO2015162552 A3 WO 2015162552A3 IB 2015052895 W IB2015052895 W IB 2015052895W WO 2015162552 A3 WO2015162552 A3 WO 2015162552A3
Authority
WO
WIPO (PCT)
Prior art keywords
composition
topic use
topic
trehalose
antioxidant
Prior art date
Application number
PCT/IB2015/052895
Other languages
French (fr)
Other versions
WO2015162552A2 (en
Inventor
Ruffo BENEDETTI
Enzo EMANUELE
Original Assignee
Biodue S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biodue S.P.A. filed Critical Biodue S.P.A.
Priority to EP15728157.7A priority Critical patent/EP3134086A2/en
Publication of WO2015162552A2 publication Critical patent/WO2015162552A2/en
Publication of WO2015162552A3 publication Critical patent/WO2015162552A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7016—Disaccharides, e.g. lactose, lactulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4172—Imidazole-alkanecarboxylic acids, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/32—Manganese; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/602—Glycosides, e.g. rutin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Birds (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Toxicology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)

Abstract

The present invention regards a composition comprising trehalose, an antioxidant and at least one pharmaceutical excipient and the use of said composition for the treatment and the prevention of skin diseases and eye disorders.
PCT/IB2015/052895 2014-04-22 2015-04-21 Composition for topic use WO2015162552A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP15728157.7A EP3134086A2 (en) 2014-04-22 2015-04-21 Composition for topic use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI2014A000748 2014-04-22
ITMI20140748 2014-04-22

Publications (2)

Publication Number Publication Date
WO2015162552A2 WO2015162552A2 (en) 2015-10-29
WO2015162552A3 true WO2015162552A3 (en) 2016-01-07

Family

ID=50981754

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2015/052895 WO2015162552A2 (en) 2014-04-22 2015-04-21 Composition for topic use

Country Status (2)

Country Link
EP (1) EP3134086A2 (en)
WO (1) WO2015162552A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018013568A1 (en) * 2016-07-11 2018-01-18 University Of North Texas Health Science Center At Fort Worth Treatment for glaucoma and other eye diseases

Citations (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4839164A (en) * 1987-02-24 1989-06-13 Estee Lauder, Inc. Trehalose containing cosmetic composition and method of using it
EP0739986A1 (en) * 1995-04-12 1996-10-30 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo High trehalose content syrup
US20030157040A1 (en) * 1998-08-01 2003-08-21 Merck Patent Gmbh Use of ectoine or ectoine derivatives in cosmetic formulations
WO2004092283A2 (en) * 2003-04-18 2004-10-28 Merck Patent Gmbh Antimicrobial pigments
JP2005179313A (en) * 2003-12-24 2005-07-07 Shu Uemura:Kk Method for producing base agent for skin cosmetic, and skin cosmetic
CN1679470A (en) * 2005-01-12 2005-10-12 凌沛学 Composition containing trehalose and transparent acid for cosmetics and preparation thereof
EP1600143A1 (en) * 2003-02-13 2005-11-30 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo SKIN PREPARATION FOR EXTERNAL USE CHARACTERIZED BY CONTAINING SUGAR DERIVATIVE OF a,a-TREHALOSE
EP1860116A1 (en) * 2006-04-07 2007-11-28 Universita' Degli Studi Di Catania Trehalose conjugate with carnosine having antioxidant activity, stable to enzymatic hydrolysis, procedure for its preparation, and pharmaceutical, cosmetic and nutraceutical compositions that contain it
CN101181279A (en) * 2007-10-16 2008-05-21 黑龙江海昌生物技术有限公司 Arificial tears containing trehalose as well as preparation and application method thereof
US20090092665A1 (en) * 2007-10-08 2009-04-09 Lux Biosciences, Inc. OPHTHALMIC COMPOSITIONS COMPRISING CALCINEURIN INHIBITORS OR mTOR INHIBITORS
US20100015072A1 (en) * 2008-06-30 2010-01-21 Christopher Polla Topical Compositions Comprising Isonicotinamide
US20100166814A1 (en) * 2008-12-24 2010-07-01 Lvmh Recherche Cosmetic Composition Containing At Least Two Osmolytes With A Moisturizing Or Antiaging Effect
CN102210684A (en) * 2011-04-29 2011-10-12 山东大学 Application of ectoine and derivants thereof in preparation of medicament for treating cataract
CN102525852A (en) * 2011-12-23 2012-07-04 广州市娇兰化妆品有限公司 Natural plant extract with sunscreen function and preparation method and application thereof
EP2494954A2 (en) * 2011-03-03 2012-09-05 Sooft Italia Spa Ophthalmic composition based on lactobionic acid useful for reducing corneal edema and inflammation
FR2975590A1 (en) * 2011-05-24 2012-11-30 Dermatologiques Uriage Lab Composition, useful e.g. for protecting skin from UV radiation, comprises e.g. ethylhexyl methoxycinnamate, methylene bis-benzotriazolyl tetramethylbutylphenol and diethylaminohydroxybenzoyl hexyl benzoate
EP2601954A1 (en) * 2010-08-06 2013-06-12 Yuasa, Makoto Therapeutic agent for disease
WO2014023649A2 (en) * 2012-08-09 2014-02-13 Unifarco S.P.A. Dermal cosmetic compositions having osmoprotecting activity

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0648114B1 (en) 1992-07-08 1997-09-17 DIANORM G. Maierhofer GmbH Liposomes, method of preparing them and their use in the preparation of drugs
ITMI20112390A1 (en) 2011-12-27 2013-06-28 Biodue S P A COMPOSITION FOR A MEDICAL DEVICE OR FOR A COSMETIC OR PHARMACEUTICAL PREPARATION
ITFI20120044A1 (en) 2012-03-01 2013-09-02 Biodue Spa FORMULATION FOR OPHTHALMIC USE INCLUDING JOJOBA OIL.
US20150132366A1 (en) 2012-07-05 2015-05-14 Biodue S.P.A. Compositions for Preventing and Repairing Skin and Ocular Damages Caused by UV Radiations

Patent Citations (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4839164A (en) * 1987-02-24 1989-06-13 Estee Lauder, Inc. Trehalose containing cosmetic composition and method of using it
EP0739986A1 (en) * 1995-04-12 1996-10-30 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo High trehalose content syrup
US20030157040A1 (en) * 1998-08-01 2003-08-21 Merck Patent Gmbh Use of ectoine or ectoine derivatives in cosmetic formulations
EP1600143A1 (en) * 2003-02-13 2005-11-30 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo SKIN PREPARATION FOR EXTERNAL USE CHARACTERIZED BY CONTAINING SUGAR DERIVATIVE OF a,a-TREHALOSE
WO2004092283A2 (en) * 2003-04-18 2004-10-28 Merck Patent Gmbh Antimicrobial pigments
JP2005179313A (en) * 2003-12-24 2005-07-07 Shu Uemura:Kk Method for producing base agent for skin cosmetic, and skin cosmetic
CN1679470A (en) * 2005-01-12 2005-10-12 凌沛学 Composition containing trehalose and transparent acid for cosmetics and preparation thereof
EP1860116A1 (en) * 2006-04-07 2007-11-28 Universita' Degli Studi Di Catania Trehalose conjugate with carnosine having antioxidant activity, stable to enzymatic hydrolysis, procedure for its preparation, and pharmaceutical, cosmetic and nutraceutical compositions that contain it
US20090092665A1 (en) * 2007-10-08 2009-04-09 Lux Biosciences, Inc. OPHTHALMIC COMPOSITIONS COMPRISING CALCINEURIN INHIBITORS OR mTOR INHIBITORS
CN101181279A (en) * 2007-10-16 2008-05-21 黑龙江海昌生物技术有限公司 Arificial tears containing trehalose as well as preparation and application method thereof
US20100015072A1 (en) * 2008-06-30 2010-01-21 Christopher Polla Topical Compositions Comprising Isonicotinamide
US20100166814A1 (en) * 2008-12-24 2010-07-01 Lvmh Recherche Cosmetic Composition Containing At Least Two Osmolytes With A Moisturizing Or Antiaging Effect
EP2601954A1 (en) * 2010-08-06 2013-06-12 Yuasa, Makoto Therapeutic agent for disease
EP2494954A2 (en) * 2011-03-03 2012-09-05 Sooft Italia Spa Ophthalmic composition based on lactobionic acid useful for reducing corneal edema and inflammation
CN102210684A (en) * 2011-04-29 2011-10-12 山东大学 Application of ectoine and derivants thereof in preparation of medicament for treating cataract
FR2975590A1 (en) * 2011-05-24 2012-11-30 Dermatologiques Uriage Lab Composition, useful e.g. for protecting skin from UV radiation, comprises e.g. ethylhexyl methoxycinnamate, methylene bis-benzotriazolyl tetramethylbutylphenol and diethylaminohydroxybenzoyl hexyl benzoate
CN102525852A (en) * 2011-12-23 2012-07-04 广州市娇兰化妆品有限公司 Natural plant extract with sunscreen function and preparation method and application thereof
WO2014023649A2 (en) * 2012-08-09 2014-02-13 Unifarco S.P.A. Dermal cosmetic compositions having osmoprotecting activity

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
ALIREZAEI M ET AL: "Betaine: a promising antioxidant agent for enhancement of broiler meat quality", BRITISH POULTRY SCIENCE, LONGMAN GROUP, GB, vol. 53, no. 5, 1 October 2012 (2012-10-01), pages 699 - 707, XP008173521, ISSN: 0007-1668, [retrieved on 20120924], DOI: 10.1080/00071668.2012.728283 *
BILSTEIN A ET AL: "Nasal spray and eye drops containing ectoine, a novel natural, non-drug anti-allergic substance are not less effective than azelastine nasal spray and eye drops in improving the symptoms of allergic rhinitis and conjunctivitis", ALLERGY (OXFORD), vol. 66, no. Suppl. 94, Sp. Iss. SI, June 2011 (2011-06-01), & 30TH CONGRESS OF THE EUROPEAN-ACADEMY-OF-ALLERGY-AND-CLINICAL-IMMUNOLOGY (EAACI); ISTANBUL, TURKEY; JUNE 11 -15, 2011, pages 132, XP008177761 *
CHAO-LING YAO ET AL: "Inhibitory effect of ectoine on melanogenesis in B16-F0 and A2058 melanoma cell lines", BIOCHEMICAL ENGINEERING JOURNAL, vol. 78, 1 September 2013 (2013-09-01), pages 163 - 169, XP055203201, ISSN: 1369-703X, DOI: 10.1016/j.bej.2013.01.005 *
ENZO EMANUELE ET AL: "Protective effect of trehalose-loaded liposomes against UVB-induced photodamage in human keratinocytes", BIOMEDICAL REPORTS, 1 July 2014 (2014-07-01), XP055154763, ISSN: 2049-9434, DOI: 10.3892/br.2014.310 *
KUDO TAKASHI ET AL: "Inhibitory effects of trehalose on malignant melanoma cell growth: implications for a novel topical anticancer agent on the ocular surface.", ISRN OPHTHALMOLOGY 2012, vol. 2012, 2012, pages 968493, XP055154765, ISSN: 2090-5688 *
MORGANTI P ET AL: "Chitin-nanofibrils: A new active cosmetic carrier", JOURNAL OF APPLIED COSMETOLOGY, INTERNATIONAL EDIEMME, ROME, IT, vol. 26, no. 3, 1 January 2008 (2008-01-01), pages 113 - 128, XP008146182, ISSN: 0392-8543 *
PLACZEK M ET AL: "Ultraviolet B-induced DNA damage in human epidermis is modified by the antioxidants ascorbic acid and D-alpha-tocopherol", JOURNAL OF INVESTIGATIVE DERMATOLOGY,, vol. 124, no. 2, 1 February 2005 (2005-02-01), pages 304 - 307, XP002384657, ISSN: 0022-202X, DOI: 10.1111/J.0022-202X.2004.23560.X *
SANGKIL LEE ET AL: "Freeze-dried Liposomes Containing Ascorbyl Palmitate Characterization and Evaluation of Freeze-dried Liposomes Loaded with Ascorbyl Palmitate Enabling Anti-aging Therapy of the Skin", BULL. KOREAN CHEM. SOC.YWC) RECEIVED NOVEMBER, 1 January 2007 (2007-01-01), XP055219255, Retrieved from the Internet <URL:journal.kcsnet.or.kr/main/j_search/j_download.htm?code=B070117> *
See also references of EP3134086A2 *
TRIPATHI M ET AL: "Glycyrrhizic acid modulates t-BHP induced apoptosis in primary rat hepatocytes", FOOD AND CHEMICAL TOXICOLOGY, PERGAMON, GB, vol. 47, no. 2, 1 February 2009 (2009-02-01), pages 339 - 347, XP026872361, ISSN: 0278-6915, [retrieved on 20081130] *
WEBB KIMBERLY M ET AL: "Role of Mn2+ and Compatible Solutes in the Radiation Resistance of Thermophilic Bacteria and Archaea (vol 2012, 845756, 2012)", ARCHAEA, 2013, XP055154767 *
WEI-DAN JIANG ET AL: "Myo-inositol prevents copper-induced oxidative damage and changes in antioxidant capacity in various organs and the enterocytes of juvenile Jian carp (var. Jian)", AQUATIC TOXICOLOGY, ELSEVIER SCIENCE PUBLISHERS BV, XX, vol. 105, no. 3, 23 August 2011 (2011-08-23), pages 543 - 551, XP028332201, ISSN: 0166-445X, [retrieved on 20110827], DOI: 10.1016/J.AQUATOX.2011.08.012 *
WITTENBERG S: "Solar radiation and the eye: a review of knowledge relevant to eye care", vol. 63, no. 8, 1 August 1986 (1986-08-01), pages 676 - 689, XP008177773, ISSN: 0093-7002, Retrieved from the Internet <URL:http://journals.lww.com/optvissci/Abstract/1986/08000/Solar_Radiation_and_the_Eye__A_Review_of_Knowledge.12.aspx> *

Also Published As

Publication number Publication date
WO2015162552A2 (en) 2015-10-29
EP3134086A2 (en) 2017-03-01

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