WO2015142903A3 - Method of controlling lactate production with piperdine-dione derivatives - Google Patents

Method of controlling lactate production with piperdine-dione derivatives Download PDF

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Publication number
WO2015142903A3
WO2015142903A3 PCT/US2015/021040 US2015021040W WO2015142903A3 WO 2015142903 A3 WO2015142903 A3 WO 2015142903A3 US 2015021040 W US2015021040 W US 2015021040W WO 2015142903 A3 WO2015142903 A3 WO 2015142903A3
Authority
WO
WIPO (PCT)
Prior art keywords
piperdine
dione derivatives
lactate production
controlling
controlling lactate
Prior art date
Application number
PCT/US2015/021040
Other languages
French (fr)
Other versions
WO2015142903A2 (en
Inventor
Inn H. Yuk
Hans PURKEY
Thomas O'brien
Original Assignee
Genentech, Inc.
F. Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech, Inc., F. Hoffmann-La Roche Ag filed Critical Genentech, Inc.
Publication of WO2015142903A2 publication Critical patent/WO2015142903A2/en
Publication of WO2015142903A3 publication Critical patent/WO2015142903A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere

Abstract

The invention provides novel compounds having the general formula: and tautomers and pharmaceutically acceptable salts thereof, wherein A1, A2, A3, A4, R1, R4, R5, R6, R7 and R8 are as defined herein, compositions including the compounds and methods of using the compounds.
PCT/US2015/021040 2014-03-17 2015-03-17 Method of controlling lactate production with piperdine-dione derivatives WO2015142903A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201461954087P 2014-03-17 2014-03-17
US61/954,087 2014-03-17
US201462032977P 2014-08-04 2014-08-04
US62/032,977 2014-08-04

Publications (2)

Publication Number Publication Date
WO2015142903A2 WO2015142903A2 (en) 2015-09-24
WO2015142903A3 true WO2015142903A3 (en) 2015-12-03

Family

ID=52824554

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2015/021040 WO2015142903A2 (en) 2014-03-17 2015-03-17 Method of controlling lactate production with piperdine-dione derivatives

Country Status (1)

Country Link
WO (1) WO2015142903A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180194769A1 (en) 2015-07-06 2018-07-12 Rodin Therapeutics, Inc. Hetero-halo inhibitors of histone deacetylase
EP3319968A1 (en) 2015-07-06 2018-05-16 Rodin Therapeutics, Inc. Heterobicyclic n-aminophenyl-amides as inhibitors of histone deacetylase
US10793567B2 (en) 2017-01-11 2020-10-06 Rodin Therapeutics, Inc. Bicyclic inhibitors of histone deacetylase
GB201707846D0 (en) * 2017-05-16 2017-06-28 Spermatech As Use
GB201707852D0 (en) * 2017-05-16 2017-06-28 Arctic Pharma As Compounds
GB201707856D0 (en) 2017-05-16 2017-06-28 Arctic Pharma As Compounds
EP3664802B1 (en) 2017-08-07 2022-02-23 Alkermes, Inc. Bicyclic inhibitors of histone deacetylase
EP3305786A3 (en) 2018-01-22 2018-07-25 Bayer CropScience Aktiengesellschaft Condensed bicyclic heterocycle derivatives as pesticides
PL3762368T3 (en) 2018-03-08 2022-06-06 Incyte Corporation Aminopyrazine diol compounds as pi3k-y inhibitors
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors
CN109369631B (en) * 2018-12-11 2020-06-30 上海皓元生物医药科技有限公司 Synthesis method of key intermediate for synthesizing lactate dehydrogenase A inhibitor
CN112142711B (en) * 2019-06-28 2022-03-29 中国科学院上海药物研究所 Substituted thiophene compound, preparation method and application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009004650A1 (en) * 2007-06-29 2009-01-08 Torrent Pharmaceuticals Ltd. Novel substituted piperidones as hsp inducers
WO2011150241A2 (en) * 2010-05-28 2011-12-01 Genentech, Inc. Decreasing lactate level and increasing polypeptide production by downregulating the expression of lactate dehydrogenase and pyruvate dehydrogenase kinase

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009004650A1 (en) * 2007-06-29 2009-01-08 Torrent Pharmaceuticals Ltd. Novel substituted piperidones as hsp inducers
WO2011150241A2 (en) * 2010-05-28 2011-12-01 Genentech, Inc. Decreasing lactate level and increasing polypeptide production by downregulating the expression of lactate dehydrogenase and pyruvate dehydrogenase kinase

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DRAGOVICH PETER S ET AL: "Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 23, no. 11, 10 April 2013 (2013-04-10), pages 3186 - 3194, XP028535180, ISSN: 0960-894X, DOI: 10.1016/J.BMCL.2013.04.001 *
JULIA BILLIARD ET AL: "Quinoline 3-sulfonamides inhibit lactate dehydrogenase A and reverse aerobic glycolysis in cancer cells", CANCER & METABOLISM, BIOMED CENTRAL LTD, LONDON, UK, vol. 1, no. 1, 6 September 2013 (2013-09-06), pages 19, XP021162565, ISSN: 2049-3002, DOI: 10.1186/2049-3002-1-19 *
TOPHAM J C ET AL: "Biochemical changes in rat liver in response to treatment with drugs and other agents-IV", BIOCHEMICAL PHARMACOLOGY, ELSEVIER, US, vol. 21, no. 7, 1 April 1972 (1972-04-01), pages 1019 - 1024, XP025541319, ISSN: 0006-2952, [retrieved on 19720401], DOI: 10.1016/0006-2952(72)90406-6 *
ZHOU M ET AL: "Decreasing lactate level and increasing antibody production in Chinese Hamster Ovary cells (CHO) by reducing the expression of lactate dehydrogenase and pyruvate dehydrogenase kinases", JOURNAL OF BIOTECHNOLOGY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 153, no. 1-2, 20 April 2011 (2011-04-20), pages 27 - 34, XP002697412, ISSN: 0168-1656, [retrieved on 20110330], DOI: 10.1016/J.JBIOTEC.2011.03.003 *

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