WO2015111004A3 - Méthode améliorée de préparation de chlorophényl-trifluoroéthanone - Google Patents

Méthode améliorée de préparation de chlorophényl-trifluoroéthanone Download PDF

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Publication number
WO2015111004A3
WO2015111004A3 PCT/IB2015/050533 IB2015050533W WO2015111004A3 WO 2015111004 A3 WO2015111004 A3 WO 2015111004A3 IB 2015050533 W IB2015050533 W IB 2015050533W WO 2015111004 A3 WO2015111004 A3 WO 2015111004A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
trifluoroethanone
chlorophenyl
improved process
efavirenz
Prior art date
Application number
PCT/IB2015/050533
Other languages
English (en)
Other versions
WO2015111004A2 (fr
Inventor
Dhananjaya GUNDLA
Kondala Rao KOTA
Srinivasa Rao ALA
Prashanth MANNE
Original Assignee
Discovery Intermediates Private Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Discovery Intermediates Private Limited filed Critical Discovery Intermediates Private Limited
Publication of WO2015111004A2 publication Critical patent/WO2015111004A2/fr
Publication of WO2015111004A3 publication Critical patent/WO2015111004A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention concerne une méthode améliorée de préparation de chlorophényl-trifluoroéthanone de formule I, un intermédiaire utilisé dans la préparation de l'éfavirenz. Formule I
PCT/IB2015/050533 2014-01-24 2015-01-24 Méthode améliorée de préparation de chlorophényl-trifluoroéthanone WO2015111004A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN304/CHE/2014 2014-01-24
IN304CH2014 IN2014CH00304A (fr) 2014-01-24 2015-01-24

Publications (2)

Publication Number Publication Date
WO2015111004A2 WO2015111004A2 (fr) 2015-07-30
WO2015111004A3 true WO2015111004A3 (fr) 2017-05-11

Family

ID=53682064

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2015/050533 WO2015111004A2 (fr) 2014-01-24 2015-01-24 Méthode améliorée de préparation de chlorophényl-trifluoroéthanone

Country Status (2)

Country Link
IN (1) IN2014CH00304A (fr)
WO (1) WO2015111004A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105777610B (zh) * 2015-10-16 2018-10-09 浙江沙星科技有限公司 一种制备4-氯-2-(三氟乙酰基)苯胺盐酸盐水合物的方法
CN106518636A (zh) * 2016-10-18 2017-03-22 浙江天宇药业股份有限公司 4‑氯‑2‑（三氟乙酰基）苯胺盐酸盐水合物及其游离碱的制备方法
CN108821938A (zh) * 2018-08-06 2018-11-16 江苏沙星化工有限公司 一种制备4-氯-2-（三氟乙酰）-苯胺盐酸盐副产物的分离方法
CN108997150B (zh) * 2018-08-31 2021-01-12 江苏沙星化工有限公司 一种依法韦仑中间体的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006098969A2 (fr) * 2005-03-09 2006-09-21 Merck & Co., Inc. Antagonistes de canaux calciques de type t a base de quinazolinone

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006098969A2 (fr) * 2005-03-09 2006-09-21 Merck & Co., Inc. Antagonistes de canaux calciques de type t a base de quinazolinone

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
RAFAEL CHINCHILLA ET AL.: "Metalated heterocycles in organic synthesis: recent applications", ARKIVOC, 2007, pages 152 - 231, XP055381156 *
WANNIAN ZHANG ET AL.: "An alternative route for synthesis of o-trifluoroacetylanilines as useful fluorine-containing intermediates", JOURNAL OF FLUORINE CHEMISTRY, vol. 131, 2010, pages 800 - 804, XP055381151 *

Also Published As

Publication number Publication date
WO2015111004A2 (fr) 2015-07-30
IN2014CH00304A (fr) 2015-09-04

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